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organophosphonates and gamma-aminobutyric acid

organophosphonates has been researched along with gamma-aminobutyric acid in 21 studies

Compound Research Comparison

Studies
(organophosphonates)
Trials
(organophosphonates)
Recent Studies (post-2010)
(organophosphonates)
Studies
(gamma-aminobutyric acid)
Trials
(gamma-aminobutyric acid)
Recent Studies (post-2010) (gamma-aminobutyric acid)
9,9688803,59640,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomyorganophosphonates (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19902 (9.52)18.7374
1990's4 (19.05)18.2507
2000's15 (71.43)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bioulac, B; de Tinguy-Moreaud, E; Neuzil, E; Vincent, JD1
Ciuffi, M; Franchi-Micheli, S; Luzzi, S; Pajani, A; Zilletti, L1
Baumann, PA; Brugger, F; Froestl, W; Gentsch, C; Hall, RG; Jaekel, J; Mickel, SJ; Olpe, HR; Strub, D; von Sprecher, G1
Enna, SJ; Harstad, EB; McCarson, KE1
Blackshaw, LA; Dent, J; Lehmann, A; Staunton, E1
Andrews, M; Brebner, K; Froestl, W; Phelan, R; Roberts, DC1
Brebner, K; Roberts, DC1
Aichholz, R; Blum, W; Desrayaud, S; Froestl, W; Kühnöl, J; Ramstein, P1
Bexis, S; Froestl, W; Kerr, DI; Marino, V; Ong, J; Parker, DA1
Dobrovitsky, V; Duarte, A; Froestl, W; Pimentel, P; Stellar, JR; Trzcińska, M1
Brändén, L; Bremner-Danielsen, M; Kärrberg, L; Lehmann, A1
Froestl, W; Markou, A; Paterson, NE2
Carai, MA; Colombo, G; Froestl, W; Gessa, GL; Serra, S; Vacca, G1
Tadeusiak, EJ1
Chebib, M; Crittenden, DL; Hanrahan, JR; Jordan, MJ; Kumar, RJ1
Froestl, W; Griffiths, RR; Kaminski, BJ; Weerts, EM1
Chowdhury, S; Greenwood, NP; Muni, NJ; Pepperberg, DR; Standaert, RF1
McCarthy, MM; Nuñez, JL1
Corrie, JE; Ogden, D; Papageorgiou, G; Trigo, FF1
Hajnal, A; Kovacs, P1

Reviews

2 review(s) available for organophosphonates and gamma-aminobutyric acid

ArticleYear
GABA modulation of cocaine self-administration.
    Annals of the New York Academy of Sciences, 2000, Volume: 909

    Topics: Animals; Baclofen; Cocaine; Conditioning, Psychological; gamma-Aminobutyric Acid; Organophosphonates; Phosphinic Acids; Reinforcement, Psychology; Self Administration

2000
Synthesis of phosphonic analogues of carnitine and gamma-amino-beta-hydroxybutyric acid.
    Bioorganic chemistry, 2004, Volume: 32, Issue:6

    Topics: Carnitine; gamma-Aminobutyric Acid; Molecular Conformation; Organophosphonates

2004

Other Studies

19 other study(ies) available for organophosphonates and gamma-aminobutyric acid

ArticleYear
[Effect of some phosphonic amino acids on the activity of central neurons].
    Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1977, Sep-19, Volume: 285, Issue:5

    Topics: Amino Acids; Animals; Brain; Cerebellum; Cerebral Cortex; gamma-Aminobutyric Acid; Neurons; Organophosphonates; Rats; Structure-Activity Relationship

1977
GABA-related activities of amino phosphonic acids on guinea-pig ileum longitudinal muscle.
    Journal of autonomic pharmacology, 1986, Volume: 6, Issue:3

    Topics: Animals; Bicuculline; Electric Stimulation; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Organophosphonates; Propylamines; Receptors, GABA-A

1986
Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
    Journal of medicinal chemistry, 1995, Aug-18, Volume: 38, Issue:17

    Topics: Animals; Behavior, Animal; Cats; Crystallography, X-Ray; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Organophosphonates; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, GABA-B; Stereoisomerism; Structure-Activity Relationship

1995
Regulation of neurokinin-1 receptor expression by GABA(B) receptor agonists.
    Life sciences, 1998, Volume: 62, Issue:17-18

    Topics: Animals; Baclofen; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Male; Organophosphonates; Pain Measurement; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Spinal Cord

1998
Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists.
    The American journal of physiology, 1999, Volume: 277, Issue:4

    Topics: Animals; Baclofen; Behavior, Animal; Deglutition; Esophagogastric Junction; Female; Ferrets; GABA Agonists; gamma-Aminobutyric Acid; Gastroesophageal Reflux; Hydrogen-Ion Concentration; Manometry; Muscle Relaxation; Organophosphonates; Organophosphorus Compounds; Phosphinic Acids; Pressure; Time Factors

1999
The GABA(B) agonist CGP 44532 decreases cocaine self-administration in rats: demonstration using a progressive ratio and a discrete trials procedure.
    Neuropharmacology, 1999, Volume: 38, Issue:11

    Topics: Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Eating; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Male; Organophosphonates; Phosphinic Acids; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration

1999
Determination of the GABA(B) receptor agonist CGP 44532 (3-amino-2-hydroxypropylmethylphosphinic acid) in rat plasma after pre-column derivatization by micro-high-performance liquid chromatography combined with negative electrospray tandem mass spectromet
    Journal of chromatography. B, Biomedical sciences and applications, 2000, Oct-10, Volume: 748, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Organophosphonates; Phosphinic Acids; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

2000
Comparative activities of the enantiomeric GABA(B) receptor agonists CGP 44532 and 44533 in central and peripheral tissues.
    European journal of pharmacology, 2001, Jan-19, Volume: 412, Issue:1

    Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Guinea Pigs; Ileum; Male; Neocortex; Organophosphonates; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Receptors, GABA-B

2001
CGP 44532, a GABAB receptor agonist, is hedonically neutral and reduces cocaine-induced enhancement of reward.
    Neuropharmacology, 2002, Volume: 42, Issue:5

    Topics: Animals; Behavior, Addictive; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Male; Organophosphonates; Phosphinic Acids; Rats; Rats, Sprague-Dawley; Reaction Time; Reward

2002
Inhibitory effects of GABA(B) receptor agonists on swallowing in the dog.
    European journal of pharmacology, 2002, Jul-12, Volume: 448, Issue:1

    Topics: Animals; Baclofen; Deglutition; Dogs; Esophagogastric Junction; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Muscle Relaxation; Organophosphonates; Phosphinic Acids; Receptors, GABA-B

2002
The GABAB receptor agonists baclofen and CGP44532 decreased nicotine self-administration in the rat.
    Psychopharmacology, 2004, Volume: 172, Issue:2

    Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; gamma-Aminobutyric Acid; Male; Nicotine; Organophosphonates; Phosphinic Acids; Rats; Rats, Wistar; Self Administration

2004
Suppression of GABA(B) receptor function in vivo by disulfide reducing agent, DL-dithiothreitol (DTT).
    Psychopharmacology, 2004, Volume: 174, Issue:2

    Topics: Animals; Baclofen; Conditioning, Operant; Discrimination Learning; Dithiothreitol; Drug Interactions; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Hydroxybutyrates; Male; Mice; Mice, Inbred DBA; Organophosphonates; Organophosphorus Compounds; Phosphinic Acids; Rats; Rats, Long-Evans; Reflex

2004
Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:1

    Topics: Animals; Body Weight; Conditioning, Operant; Cues; Food; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Male; Nicotine; Nicotinic Agonists; Organophosphonates; Phosphinic Acids; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration; Tobacco Use Disorder

2005
Stabilization of zwitterions in solution: phosphinic and phosphonic acid GABA analogues.
    The journal of physical chemistry. A, 2005, Sep-22, Volume: 109, Issue:37

    Topics: Amines; Drug Stability; gamma-Aminobutyric Acid; Gases; Ions; Models, Molecular; Molecular Conformation; Organophosphonates; Phosphinic Acids; Solutions; Thermodynamics

2005
Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons.
    Drug and alcohol dependence, 2007, Jul-10, Volume: 89, Issue:2-3

    Topics: Animals; Appetitive Behavior; Baclofen; Cocaine-Related Disorders; GABA Antagonists; GABA-B Receptor Agonists; gamma-Aminobutyric Acid; Male; Motivation; Nipecotic Acids; Organophosphonates; Papio anubis; Phosphinic Acids; Self Administration; Tiagabine

2007
Phosphonic acid analogs of GABA through reductive dealkylation of phosphonic diesters with lithium trialkylborohydrides.
    Bioorganic & medicinal chemistry letters, 2007, Jul-01, Volume: 17, Issue:13

    Topics: Animals; Borohydrides; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Drug Design; Esters; gamma-Aminobutyric Acid; Inhibitory Concentration 50; Lithium; Magnetic Resonance Spectroscopy; Models, Chemical; Neurotransmitter Agents; Oocytes; Organophosphonates; Xenopus laevis

2007
Resting intracellular calcium concentration, depolarizing Gamma-Aminobutyric Acid and possible role of local estradiol synthesis in the developing male and female hippocampus.
    Neuroscience, 2009, Jan-23, Volume: 158, Issue:2

    Topics: Androstenedione; Animals; Animals, Newborn; Aromatase Inhibitors; Calcium; Cells, Cultured; Chelating Agents; Egtazic Acid; Estradiol; Estrogen Antagonists; Excitatory Amino Acid Agents; Extracellular Fluid; Female; Fulvestrant; GABA Agonists; gamma-Aminobutyric Acid; Gene Expression Regulation; Hippocampus; Male; Muscimol; Neurons; Organophosphonates; Piperazines; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2

2009
Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ.
    Journal of neuroscience methods, 2009, Jul-30, Volume: 181, Issue:2

    Topics: Animals; Cells, Cultured; Cerebellum; Electrophysiology; gamma-Aminobutyric Acid; Hippocampus; Indoles; Lasers; Neural Inhibition; Neurons; Organophosphonates; Photolysis; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Synaptic Transmission

2009
In vivo electrophysiological effects of insulin in the rat brain.
    Neuropeptides, 2009, Volume: 43, Issue:4

    Topics: Action Potentials; Animals; Cerebellar Cortex; Electrophysiology; gamma-Aminobutyric Acid; Insulin; Iontophoresis; Male; Naphthalenes; Neurons; Organophosphonates; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction

2009