organophosphonates has been researched along with fosmidomycin in 12 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (fosmidomycin) | Trials (fosmidomycin) | Recent Studies (post-2010) (fosmidomycin) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 243 | 10 | 116 |
| Protein | Taxonomy | organophosphonates (IC50) | fosmidomycin (IC50) |
|---|---|---|---|
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Mycolicibacterium smegmatis MC2 155 | 0.295 | |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | 0.0334 | |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Mycobacterium tuberculosis H37Rv | 0.165 | |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic | Arabidopsis thaliana (thale cress) | 0.1 | |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli | 0.438 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 9 (75.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bach, TJ; Grosdemange-Billiard, C; Hemmerlin, A; Kuntz, L; Rohmer, M; Tritsch, D; Willem, A | 1 |
| Giessmann, D; Haemers, T; Heidler, P; Jomaa, H; Link, A; Reichenberg, A; Sanderbrand, S; Van Calenbergh, S; Weidemeyer, C; Wiesner, J | 1 |
| Grosdemange-Billiard, C; Kuntz, L; Rohmer, M; Tritsch, D; Zinglé, C | 1 |
| Bae, B; Circello, BT; Kuemin, M; Lee, JH; Metcalf, WW; Nair, SK; van der Donk, WA | 1 |
| Blatch, GL; Bodill, T; Conibear, AC; Kaye, PT; Lobb, KA | 1 |
| Andaloussi, M; Björkelid, C; Iyer, H; Karlén, A; Larhed, M; Lindh, M; Suresh, S; Wieckowska, A | 1 |
| Bae, B; Cobb, RE; DeSieno, MA; Nair, SK; Zhao, H | 1 |
| Grosdemange-Billiard, C; Ponaire, S; Rohmer, M; Tritsch, D; Zinglé, C | 1 |
| Bartee, D; Freel Meyers, CL; Harrison, MJ; Koppisch, AT; Phillips, PD; Sanders, S | 1 |
| Caljon, G; Cos, P; Courtens, C; Martin, A; Risseeuw, M; Van Calenbergh, S | 1 |
| Eliot, AC; Erb, A; Ju, KS; Metcalf, WW; Parkinson, EI | 1 |
| Caljon, G; Coenye, T; Cos, P; Courtens, C; Quennesson, T; Risseeuw, M; Van Calenbergh, S; van Charante, F | 1 |
12 other study(ies) available for organophosphonates and fosmidomycin
| Article | Year |
|---|---|
Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomerase.
Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Antimalarials; Butyrates; Drug Design; Drug Resistance, Multiple, Bacterial; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fosfomycin; Hydroxamic Acids; Microbial Sensitivity Tests; Multienzyme Complexes; NADP; Organophosphonates; Oxidoreductases; Terpenes | 2005 |
Towards new antimalarial drugs: synthesis of non-hydrolyzable phosphate mimics as feed for a predictive QSAR study on 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors.
Topics: Aldose-Ketose Isomerases; Animals; Antimalarials; Drug Design; Enzyme Inhibitors; Escherichia coli; Fosfomycin; Multienzyme Complexes; Organophosphonates; Oxidoreductases; Plasmodium falciparum; Quantitative Structure-Activity Relationship | 2008 |
Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase.
Topics: Aldose-Ketose Isomerases; Enzyme Inhibitors; Erythritol; Fosfomycin; Molecular Structure; Multienzyme Complexes; Organophosphonates; Oxidoreductases; Structure-Activity Relationship; Sugar Phosphates; Terpenes | 2010 |
Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis.
Topics: Bioengineering; Biosynthetic Pathways; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Crystallography, X-Ray; Dipeptides; Esterification; Fosfomycin; Kinetics; Mass Spectrometry; Methylation; Methyltransferases; Molecular Structure; Organophosphonates; S-Adenosylmethionine; Streptomyces; Substrate Specificity | 2010 |
Synthesis and evaluation of phosphonated N-heteroarylcarboxamides as DOXP-reductoisomerase (DXR) inhibitors.
Topics: Aldose-Ketose Isomerases; Antimalarials; Computer Simulation; Drug Design; Fosfomycin; Furans; Molecular Structure; Multienzyme Complexes; Organophosphonates; Oxidoreductases; Protein Binding | 2011 |
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: an attempt to improve the activity against Mycobacterium tuberculosis.
Topics: Aldose-Ketose Isomerases; Antitubercular Agents; Crystallography, X-Ray; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fosfomycin; Hydroxamic Acids; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Multienzyme Complexes; Mycobacterium tuberculosis; Organophosphonates; Oxidoreductases; Stereoisomerism; Structure-Activity Relationship | 2011 |
New N-acetyltransferase fold in the structure and mechanism of the phosphonate biosynthetic enzyme FrbF.
Topics: Acetyltransferases; Bacterial Proteins; Catalytic Domain; Crystallography, X-Ray; Fosfomycin; Organophosphonates; Protein Folding; Protein Structure, Tertiary; Streptomyces; Structure-Activity Relationship | 2011 |
Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agents.
Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Enzyme Inhibitors; Fosfomycin; Hydrophobic and Hydrophilic Interactions; Kinetics; Microbial Viability; Multienzyme Complexes; Mycobacterium smegmatis; Organophosphonates; Oxazines; Oxidoreductases; Prodrugs; Xanthenes | 2012 |
Growth medium-dependent antimicrobial activity of early stage MEP pathway inhibitors.
Topics: Aldose-Ketose Isomerases; Anti-Bacterial Agents; Bacillus thuringiensis; Culture Media; Drug Interactions; Enterobacteriaceae; Erythritol; Escherichia coli Proteins; Fosfomycin; Metabolic Networks and Pathways; Microbial Sensitivity Tests; Multienzyme Complexes; Nutrients; Organophosphonates; Terpenes; Transferases | 2018 |
Phosphonodiamidate prodrugs of N-alkoxy analogs of a fosmidomycin surrogate as antimalarial and antitubercular agents.
Topics: Antimalarials; Antitubercular Agents; Cell Line; Cell Survival; Fosfomycin; Humans; Hydroxamic Acids; Mycobacterium tuberculosis; Organophosphonates; Plasmodium falciparum; Prodrugs | 2019 |
Fosmidomycin biosynthesis diverges from related phosphonate natural products.
Topics: Biological Products; Fosfomycin; Genes, Bacterial; Multigene Family; Organophosphonates; Streptomyces | 2019 |
Acyloxymethyl and alkoxycarbonyloxymethyl prodrugs of a fosmidomycin surrogate as antimalarial and antibacterial agents.
Topics: Anti-Bacterial Agents; Antimalarials; Folic Acid Antagonists; Humans; Malaria, Falciparum; Mycobacterium tuberculosis; Organophosphonates; Prodrugs; Tuberculosis | 2023 |