organophosphonates has been researched along with endothelin-1 in 31 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (endothelin-1) | Trials (endothelin-1) | Recent Studies (post-2010) (endothelin-1) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 12,740 | 632 | 3,394 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (35.48) | 18.2507 |
| 2000's | 15 (48.39) | 29.6817 |
| 2010's | 5 (16.13) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Lombaert, S; Ghai, RD; Jeng, AY; Trapani, AJ; Webb, RL | 1 |
| Barou, V; de Nanteuil, G; Descombes, JJ; Laubie, M; Mennecier, P; Verbeuren, TJ; Versluys, D | 1 |
| De Lombaert, S; Jeng, AY; Kuzmich, S; Trapani, AJ | 1 |
| Arthur, A; Caner, HH; Jeng, AY; Kassell, NF; Kwan, AL; Lappe, RW; Lee, KS | 1 |
| Held, HD; Raschak, M; Uhlig, S | 1 |
| Chou, M; Jeng, AY; Marcopulos, N; Moliterni, JA; Moskal, MA; Neubert, AD; Savage, P; Stamford, LB; Trapani, AJ; Wallace, EM | 1 |
| Battistini, B; Jeng, AY; Pelletier, S; Sirois, P | 1 |
| De Lombaert, S; DelGrande, D; Jeng, AY; Savage, P; Shetty, SS | 1 |
| deWit, D; Emoto, N; Télémaque, S; Yanagisawa, M | 1 |
| Barker, S; Mitchell, JA; Rees, GM; Walcot, NR; Warner, TD; Wood, EG; Woods, M | 1 |
| Carr, MJ; Goldie, RG; Henry, PJ; Jeng, AY | 1 |
| Blanchard, L; Chou, M; De Lombaert, S; Fitt, J; Hoyer, D; Jeng, AY; Marcopoulos, N; Moliterni, J; Satoh, Y; Savage, P; Simonsbergen, D; Stamford, LB; Tan, J; Trapani, AJ; Wallace, EM | 1 |
| Battistini, B; McKay, KO; Yap, EY | 1 |
| Battistini, B; Gray, GA; Webb, DJ | 1 |
| Beil, ME; Bruseo, CW; Chou, M; De Lombaert, S; Jeng, AY; Savage, P; Trapani, AJ | 1 |
| Chang, CZ; Howng, SL; Jeng, AY; Kwan, AL; Lin, CL; Winardi, D; Yen, CP | 1 |
| Boileau, G; Dai, J; Geng, Y; Giancotti, FG; Knudsen, B; Nanus, DM; Navarro, D; Papandreou, CN; Shen, R; Sumitomo, M; Walburg, M | 1 |
| De Campo, BA; Goldie, RG; Henry, PJ; Jeng, AY | 1 |
| Ayach, B; Battistini, B; Blouin, A; Jeng, AY; Molez, S | 1 |
| Nakayama, Y; Tomita, K | 1 |
| Goto, K | 1 |
| Adiarto, S; Emoto, N; Isaka, D; Jeng, AY; Masuda, S; Raharjo, SB; Yokoyama, M | 1 |
| D'Orléans-Juste, P; Fecteau, MH; Honoré, JC; Labonté, J; Plante, M; Rae, GA | 1 |
| Arsenault, D; Battistini, B; Beaudoin, M; Belleville, K; Benrezzak, O; Blouin, A; Cayer, J; Daull, P; Jeng, AY; Nantel, F; Pheng, LH; Sirois, P | 1 |
| Slomiany, A; Slomiany, BL | 1 |
| Arribas-Gomez, I; Lopez-Ongil, S; Martinez-Miguel, P; Raoch, V; Rodriguez-Puyol, D; Rodriguez-Puyol, M | 1 |
| Kamata, K; Kobayashi, T; Matsumoto, T; Ozawa, Y; Taguchi, K | 1 |
| Chai, CY; Chen, IJ; Chou, SH; Dai, ZK; Hsieh, CC; Jeng, AY; Tan, MS; Wu, BN; Wu, JR; Yeh, JL | 1 |
| Drevenšek, G; Ljuca, F; Zerem, E | 1 |
| Chou, SH; Feske, SK; Hanchapola, I; Kuruppu, S; Lo, EH; Ning, M; Smith, AI; Suh, S | 1 |
| Chung, CL; Kassell, NF; Kwan, AL; Lee, PY; Loh, JK; Tsai, HP; Wang, CJ; Wu, BN; Wu, SC | 1 |
2 review(s) available for organophosphonates and endothelin-1
| Article | Year |
|---|---|
[Endothelin and kidney disease].
Topics: Animals; Aspartic Acid Endopeptidases; Autocrine Communication; Cell Division; Cyclosporine; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Gene Expression; Glomerular Mesangium; Humans; Kidney Diseases; Metalloendopeptidases; Organophosphonates; Tetrazoles; Vasoconstriction | 2004 |
[Prospects for endothelin-related drugs].
Topics: Animals; Aspartic Acid Endopeptidases; Bosentan; Cardiovascular Diseases; Drug Design; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Hemodynamics; Humans; Metalloendopeptidases; Organophosphonates; Peptides, Cyclic; Quinazolines; Receptors, Endothelin; Sulfonamides; Sulfonylurea Compounds; Tetracyclines; Tetrazoles | 2004 |
29 other study(ies) available for organophosphonates and endothelin-1
| Article | Year |
|---|---|
Pharmacological profile of a non-peptidic dual inhibitor of neutral endopeptidase 24.11 and endothelin-converting enzyme.
Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Atrial Natriuretic Factor; Blood Pressure; Cell Membrane; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Kidney Cortex; Kinetics; Male; Metalloendopeptidases; Molecular Sequence Data; Neprilysin; Oligopeptides; Organophosphonates; Phenylalanine; Protein Precursors; Rats; Rats, Inbred SHR; Substrate Specificity; Tetrazoles | 1994 |
S 17162 is a novel selective inhibitor of big ET-1 responses in the rat.
Topics: Animals; Aspartic Acid Endopeptidases; Blood Pressure; Dipeptides; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Kidney; Male; Metalloendopeptidases; Norepinephrine; Organophosphonates; Perfusion; Protease Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley | 1995 |
Inhibition of big ET-1-induced pressor response by an orally active dual inhibitor of endothelin-converting enzyme and neutral endopeptidase 24.11.
Topics: Administration, Oral; Animals; Aspartic Acid Endopeptidases; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Protease Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Tetrazoles | 1995 |
Systemic administration of an inhibitor of endothelin-converting enzyme for attenuation of cerebral vasospasm following experimental subarachnoid hemorrhage.
Topics: Animals; Disease Models, Animal; Endothelin-1; Endothelins; Ischemic Attack, Transient; Organophosphonates; Protease Inhibitors; Protein Precursors; Rabbits; Subarachnoid Hemorrhage; Tetrazoles; Time Factors | 1996 |
Rat big endothelin-1-induced bronchoconstriction and vasoconstriction in the isolated perfused rat lung: role of endothelin converting enzyme and neutral endopeptidase 24.11.
Topics: Airway Resistance; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Bronchoconstriction; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Female; Glycopeptides; Lung; Metalloendopeptidases; Neprilysin; Organophosphonates; Perfusion; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Tetrazoles; Thiorphan; Vascular Resistance; Vasoconstriction | 1997 |
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.
Topics: Acetylene; Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Blood Pressure; CHO Cells; Cricetinae; Drug Design; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; Humans; Male; Metalloendopeptidases; Molecular Sequence Data; Neprilysin; Organophosphonates; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Structure-Activity Relationship | 1998 |
Effects of dual endothelin-converting enzyme/neutral endopeptidase inhibitors, CGS 26303 and CGS 26393, on lipopolysaccharide or interleukin-1 beta-stimulated release of endothelin from guinea pig tracheal epithelial cells.
Topics: Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Endothelin-1; Endothelin-Converting Enzymes; Epithelial Cells; Guinea Pigs; Interleukin-1; Lipopolysaccharides; Male; Metalloendopeptidases; Organophosphonates; Phenylalanine; Protease Inhibitors; Tetrazoles; Trachea | 1998 |
Characterization of CGS 31447, a potent and nonpeptidic endothelin-converting enzyme inhibitor.
Topics: Animals; Aspartic Acid Endopeptidases; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Humans; In Vitro Techniques; Kidney; Kinetics; Male; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Protein Binding; Protein Precursors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Renal Circulation; Tetrazoles | 1998 |
In vivo role of endothelin-converting enzyme-1 as examined by adenovirus-mediated overexpression in rats.
Topics: Adenoviridae Infections; Animals; Aspartic Acid Endopeptidases; Azepines; Blood Pressure; Cattle; DNA, Complementary; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Humans; Hypertension; Indoles; Male; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Receptor, Endothelin A; Tetrazoles | 1998 |
Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme.
Topics: Aspartic Acid Endopeptidases; Cells, Cultured; Cytokines; Drug Interactions; Endothelin-1; Endothelin-Converting Enzymes; Glycopeptides; Humans; Interferon-gamma; Mammary Arteries; Metalloendopeptidases; Muscle, Smooth, Vascular; Organophosphonates; Phenylalanine; Protease Inhibitors; RNA, Messenger; Saphenous Vein; Tetrazoles; Tumor Necrosis Factor-alpha | 1999 |
The role of endothelin in mediating virus-induced changes in endothelinB receptor density in mouse airways.
Topics: Animals; Autoradiography; Disease Models, Animal; Down-Regulation; Endothelin-1; Influenza A virus; Lung; Male; Mice; Mice, Inbred CBA; Muscle, Smooth; Neprilysin; Organ Size; Organophosphonates; Orthomyxoviridae Infections; Protease Inhibitors; Receptor, Endothelin B; Receptors, Endothelin; Tetrazoles; Trachea | 1999 |
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Humans; Male; Metalloendopeptidases; Organophosphonates; Protein Precursors; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tetrazoles | 2000 |
Contraction to big endothelin-1, big endothelin-2 and big endothelin-3, and endothelin-converting enzyme inhibition in human isolated bronchi.
Topics: Aspartic Acid Endopeptidases; Bronchi; Endothelin-1; Endothelin-2; Endothelin-3; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Glycopeptides; Humans; In Vitro Techniques; Lung; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Protein Precursors; Tetrazoles | 2000 |
Endothelins are potent vasoconstrictors, and much more besides.
Topics: Aspartic Acid Endopeptidases; Benzazepines; Benzhydryl Compounds; Benzofurans; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Heart Failure; Humans; Metalloendopeptidases; Organophosphonates; Pyrimidines; Vascular Diseases; Vasoconstrictor Agents | 2000 |
CGS 34043: a non-peptidic, potent and long-acting dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11.
Topics: Animals; Aspartic Acid Endopeptidases; Atrial Natriuretic Factor; Blood Pressure; COS Cells; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; Humans; Kidney Cortex; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Prodrugs; Protein Precursors; Rats; Rats, Sprague-Dawley; Tetrazoles | 2000 |
Effects of endothelin-converting enzyme inhibitors on hemolysate-induced morphological changes and production of endothelin-1 in bovine cerebrovascular endothelial cells.
Topics: Animals; Aspartic Acid Endopeptidases; Cattle; Cells, Cultured; Cerebral Arteries; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-Converting Enzymes; Endothelium, Vascular; Metalloendopeptidases; Organophosphonates; Protease Inhibitors; Tetrazoles | 2000 |
Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling.
Topics: Animals; Bombesin; Cell Movement; COS Cells; Culture Media, Serum-Free; DNA, Recombinant; Endothelin-1; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Male; Membrane Proteins; Neprilysin; Organophosphonates; Phenylalanine; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; src-Family Kinases; Tumor Cells, Cultured | 2000 |
Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Chymases; Egg Hypersensitivity; Endothelin-1; Endothelin-Converting Enzymes; Endothelins; Enzyme Inhibitors; In Vitro Techniques; Male; Mast Cells; Metalloendopeptidases; Mice; Mice, Inbred CBA; Muscle Contraction; Neprilysin; Organophosphonates; Ovalbumin; Peptide Fragments; Phenylalanine; Protein Precursors; Random Allocation; Serine Endopeptidases; Trachea | 2002 |
Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartic Acid Endopeptidases; Benzazepines; Benzofurans; Blood Pressure; Drug Therapy, Combination; Endothelin-1; Endothelin-Converting Enzymes; Hypertension; Male; Metalloendopeptidases; Organophosphonates; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2002 |
Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartic Acid Endopeptidases; Atrial Natriuretic Factor; Cardiac Output, Low; Cardiomegaly; Collagen; Echocardiography; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; Fibrosis; Heart; Male; Metalloendopeptidases; Myocardium; Neprilysin; Neurotransmitter Agents; Organophosphonates; Phenylalanine; Rats; Rats, Inbred Dahl; RNA, Messenger; Tetrazoles; Thiazepines | 2005 |
Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Female; Glycopeptides; Heart Ventricles; Injections; Male; Metalloendopeptidases; Neprilysin; Organophosphonates; Peptide Fragments; Protease Inhibitors; Rabbits; Receptors, Endothelin; Thiorphan | 2005 |
Triple vasopeptidase inhibition normalizes blood pressure in conscious, unrestrained, and spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aspartic Acid Endopeptidases; Atrial Natriuretic Factor; Benzazepines; Benzofurans; Blood Pressure; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-Converting Enzymes; Hypertension; Indoles; Male; Metalloendopeptidases; Neprilysin; Nitric Oxide; Organophosphonates; Phenylalanine; Protease Inhibitors; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species | 2005 |
Cytosolic phospholipase A2 activation in Helicobacter pylori lipopolysaccharide-induced interference with gastric mucin synthesis.
Topics: Androstadienes; Animals; Arachidonic Acids; Endothelin-1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gastric Mucosa; Ginkgolides; Lactones; Lipopolysaccharides; Models, Biological; Mucins; Organophosphonates; Phosphatidylcholines; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Rats; Rats, Sprague-Dawley; Wortmannin | 2006 |
The peptidase inhibitor CGS-26303 increases endothelin converting enzyme-1 expression in endothelial cells through accumulation of big endothelin-1.
Topics: Animals; Aorta, Thoracic; Aspartic Acid Endopeptidases; Blotting, Northern; Blotting, Western; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelin-1; Endothelin-Converting Enzymes; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Humans; Metalloendopeptidases; Methyltransferases; Neprilysin; Organophosphonates; Promoter Regions, Genetic; Protease Inhibitors; Tetrazoles; Transfection | 2007 |
Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.
Topics: Animals; Aspartic Acid Endopeptidases; Benzofurans; Blood Glucose; Body Weight; Coronary Vessels; Diabetes Mellitus, Experimental; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; Glycopeptides; Heart; Lipids; Lysine; Male; Metalloendopeptidases; Myocardium; Oligopeptides; Organ Size; Organophosphonates; Peptides, Cyclic; Perfusion; Piperidines; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Thiorphan; Vasoconstriction | 2010 |
Protective effects of a dual endothelin converting enzyme/neutral endopeptidase inhibitor on the development of pulmonary hypertension secondary to cardiac dysfunction in the rat.
Topics: Animals; Aspartic Acid Endopeptidases; Blood Pressure; Endothelin-1; Endothelin-Converting Enzymes; Hypertension, Pulmonary; Lung; Metalloendopeptidases; Neprilysin; Nitric Oxide Synthase Type III; Organophosphonates; Protease Inhibitors; Pulmonary Artery; Rats; Rats, Wistar; Tetrazoles; Up-Regulation | 2010 |
Contribution of Ras farnesyl transferase, MAP kinase and cytochrome P-450 metabolites to endothelin-1 induced hypertension.
Topics: Alkyl and Aryl Transferases; Animals; Arachidonic Acid; Blood Pressure; Cytochrome P-450 Enzyme System; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Fatty Acids, Unsaturated; Flavonoids; Hypertension; Infusions, Intravenous; Male; MAP Kinase Signaling System; Organophosphonates; Rats; Rats, Sprague-Dawley; Signal Transduction | 2011 |
Soluble and catalytically active endothelin converting enzyme-1 is present in cerebrospinal fluid of subarachnoid hemorrhage patients.
Topics: Aspartic Acid Endopeptidases; Benzofurans; Bradykinin; Endothelin-1; Endothelin-Converting Enzymes; Enzyme Inhibitors; Humans; Hydrocephalus; Mass Spectrometry; Metalloendopeptidases; Organophosphonates; Subarachnoid Hemorrhage | 2014 |
Alteration of basilar artery rho-kinase and soluble guanylyl cyclase protein expression in a rat model of cerebral vasospasm following subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Behavior, Animal; Cyclic AMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelin-1; Guanylate Cyclase; Male; Organ Specificity; Organophosphonates; Protein Kinase C-delta; Protein Kinase Inhibitors; Protein Transport; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; rho-Associated Kinases; Signal Transduction; Soluble Guanylyl Cyclase; Subarachnoid Hemorrhage; Tetrazoles; Vasospasm, Intracranial | 2014 |