organophosphonates has been researched along with eaa-090 in 10 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (eaa-090) | Trials (eaa-090) | Recent Studies (post-2010) (eaa-090) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 11 | 3 | 3 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abou-Gharbia, M; Bramlett, DR; Garrison, DT; Kinney, WA; Kowal, DM; Miller, TL; Moyer, JA; Schmid, J; Tasse, RP; Zaleska, MM | 1 |
| Baudy, R; Chiu, D; Kowal, D; Lin, S; Olney, J; Simon, R; Smeyne, M; Sun, L; Zukin, RS | 1 |
| Brandt, MR; Cummons, TA; Potestio, L; Rosenzweig-Lipson, S; Sukoff, SJ | 1 |
| Eppler, MC; Kushiro, T; Muir, WW; Wiese, AJ | 1 |
| Abou-Gharbia, MA; Baudy, RB; Brandt, MR; Butera, JA; Chen, H; Childers, WE; Cummons, TA; Harrison, B; Hoffmann, M; Jain, U; Kennedy, J; Kowal, D; Magolda, R; May, M; Mugford, C; Pangalos, MN; Sze, JY; Zupan, B | 1 |
| Eppler, CM; Lerche, P; Muir, WW; Ueyama, Y | 1 |
| del Rio, CL; Muir, WW; Pollet, RA; Zwijnenberg, RJ | 1 |
| L del Rio, C; Muir, WW; Pollet, RA; Zwijnenberg, RJ | 1 |
| Al-Nadaf, S; Budsberg, SC; Cathcart, CJ; Clark, JD; Eppler, CM; Reynolds, LR; Torres, BT; Zwijnenberg, RJ | 1 |
| Dehmel, M; Fischer, C; Henle, F; Leemhuis, J; Meyer, DK | 1 |
3 trial(s) available for organophosphonates and eaa-090
| Article | Year |
|---|---|
Effects of perzinfotel on the minimum alveolar concentration of isoflurane in dogs.
Topics: Analgesics; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Azabicyclo Compounds; Blood Pressure; Body Temperature; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Isoflurane; Male; Organophosphonates; Pulmonary Alveoli | 2007 |
Effects of intravenous administration of perzinfotel, fentanyl, and a combination of both drugs on the minimum alveolar concentration of isoflurane in dogs.
Topics: Adjuvants, Anesthesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Azabicyclo Compounds; Blood Pressure; Cross-Over Studies; Dogs; Drug Therapy, Combination; Female; Fentanyl; Injections, Intravenous; Isoflurane; Male; Organophosphonates; Pulmonary Alveoli | 2009 |
Effect of perzinfotel and a proprietary phospholipase A(2) inhibitor on kinetic gait and subjective lameness scores in dogs with sodium urate-induced synovitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azabicyclo Compounds; Blood Proteins; Carbazoles; Cross-Over Studies; Dog Diseases; Dogs; Excitatory Amino Acid Antagonists; Female; Gait; Kinetics; Lameness, Animal; Male; Organophosphonates; Synovitis; Uric Acid | 2011 |
7 other study(ies) available for organophosphonates and eaa-090
| Article | Year |
|---|---|
Design and synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid (EAA-090), a potent N-methyl-D-aspartate antagonist, via the use of 3-cyclobutene-1,2-dione as an achiral alpha-amino acid bioisostere.
Topics: Animals; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cyclobutanes; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Ischemic Attack, Transient; Mice; Models, Chemical; N-Methylaspartate; Organophosphonates; Pipecolic Acids; Piperazines; Rats | 1998 |
Characterization of two novel N-methyl-D-aspartate antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic acid hydrochloride).
Topics: Animals; Azabicyclo Compounds; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Neurons; Organophosphonates; Propionates; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Xenopus laevis | 2004 |
Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity.
Topics: Analgesics; Animals; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dinoprostone; Excitatory Amino Acid Antagonists; Hot Temperature; Male; Morphine; Organophosphonates; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2005 |
Prodrugs of perzinfotel with improved oral bioavailability.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Bile; Biological Availability; Diphosphonates; Drug Stability; Gastric Juice; Male; Organophosphonates; Prodrugs; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2009 |
Effects of perzinfotel on the minimum alveolar concentration of isoflurane in dogs when administered as a preanesthetic via various routes or in combination with butorphanol.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Azabicyclo Compounds; Blood Pressure; Body Temperature; Butorphanol; Cross-Sectional Studies; Dogs; Drug Interactions; Electroencephalography; Female; Heart Rate; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Isoflurane; Least-Squares Analysis; Male; Organophosphonates; Oximetry; Pulmonary Alveoli; Receptors, N-Methyl-D-Aspartate | 2010 |
Effects of perzinfotel, butorphanol tartrate, and a butorphanol-perzinfotel combination on the minimum alveolar concentration of isoflurane in cats.
Topics: Animals; Azabicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Butorphanol; Cats; Consciousness; Cross-Over Studies; Drug Combinations; Electric Stimulation; Female; Isoflurane; Male; Mouth Mucosa; Neuronal Plasticity; Organophosphonates; Pulmonary Alveoli; Synaptic Transmission; Telemetry | 2010 |
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons.
Topics: Animals; Azabicyclo Compounds; Cells, Cultured; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; HeLa Cells; Hippocampus; Humans; N-Methylaspartate; Neurons; Organophosphonates; Phenols; Piperidines; Protein Subunits; Pseudopodia; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2012 |