Compounds > organophosphonates
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organophosphonates and cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

organophosphonates has been researched along with cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine in 9 studies

Compound Research Comparison

Studies
(organophosphonates)		Trials
(organophosphonates)		Recent Studies (post-2010)
(organophosphonates)		Studies
(cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine)		Trials
(cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine)		Recent Studies (post-2010) (cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine)
9,9688803,5962214

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (66.67)18.2507
2000's1 (11.11)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andrei, G; De Clercq, E; Neyts, J; Schols, D; Snoeck, R1
Barkhimer, DB; Bischofberger, N; Chen, MS; Cundy, KC; Hitchcock, MJ; Kent, KM; Lacy, SA; Lee, WA; Li, ZH; Mendel, DB1
Cundy, KC; Hitchcock, MJ; Lee, WA; Lynch, G; Shaw, JP1
Bidgood, AM; Cundy, KC; Griffin, L; Lee, WA; Lynch, G; Shaw, JP1
Barditch-Crovo, P; Cundy, KC; Jaffe, HS; Lietman, PS; Petty, BG; Redpath, M; Ruby, A1
Lee, WA; Oliyai, R; Visor, GC; Yuan, LC1
Bailey, KW; Sidwell, RW; Smee, DF1
Kashemirov, BA; Krylov, IS; McKenna, CE; Peterson, LW; Sala-Rabanal, M; Serpi, M1
Andrei, G; Coen, N; Duraffour, S; Krecmerová, M; Naesens, L; Snoeck, R; Van den Oord, J1

Trials

1 trial(s) available for organophosphonates and cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

ArticleYear
Clinical pharmacokinetics of 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine in human immunodeficiency virus-infected patients.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:2

    Topics: Administration, Oral; Adult; Anti-HIV Agents; Biological Availability; Cidofovir; Cytosine; Female; HIV Infections; Humans; Injections, Intravenous; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs

1999

Other Studies

8 other study(ies) available for organophosphonates and cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine

ArticleYear
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique.
    Antiviral research, 1991, Volume: 16, Issue:1

    Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytomegalovirus; Cytosine; Flow Cytometry; Ganciclovir; Humans; Microbial Sensitivity Tests; Nucleic Acid Hybridization; Organophosphonates; Organophosphorus Compounds; Viral Plaque Assay

1991
1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:10

    Topics: Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Drug Stability; Female; Humans; Male; Mice; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley

1994
Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits.
    Current eye research, 1996, Volume: 15, Issue:5

    Topics: AIDS-Related Opportunistic Infections; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus Retinitis; Cytosine; Eye; Half-Life; Humans; Injections; Kidney; Male; Organophosphonates; Organophosphorus Compounds; Rabbits; Retina; Tissue Distribution; Vitreous Body

1996
Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats.
    Drug metabolism and disposition: the biological fate of chemicals, 1996, Volume: 24, Issue:7

    Topics: Administration, Cutaneous; Animals; Antiviral Agents; Biological Availability; Carbon Radioisotopes; Cidofovir; Cytosine; Female; Injections, Intravenous; Male; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; Tissue Distribution; Virus Diseases

1996
Enhanced chemical stability of the intracellular prodrug, 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, relative to its parent compound, cidofovir.
    International journal of pharmaceutics, 1999, Mar-15, Volume: 179, Issue:2

    Topics: Antiviral Agents; Cidofovir; Cytosine; Drug Stability; Hydrolysis; Kinetics; Organophosphonates; Organophosphorus Compounds; Prodrugs; Solubility

1999
Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in mice.
    Chemotherapy, 2003, Volume: 49, Issue:3

    Topics: Administration, Intranasal; Animals; Antiviral Agents; Cidofovir; Cowpox; Cytosine; Female; Infusions, Parenteral; Liver; Lung Diseases; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Vaccinia

2003
Serine side chain-linked peptidomimetic conjugates of cyclic HPMPC and HPMPA: synthesis and interaction with hPEPT1.
    Molecular pharmaceutics, 2010, Dec-06, Volume: 7, Issue:6

    Topics: Adenine; Cytosine; Dipeptides; Humans; Molecular Structure; Organophosphonates; Organophosphorus Compounds; Peptide Transporter 1; Prodrugs; Serine; Stereoisomerism; Symporters

2010
Evaluation of novel acyclic nucleoside phosphonates against human and animal gammaherpesviruses revealed an altered metabolism of cyclic prodrugs upon Epstein-Barr virus reactivation in P3HR-1 cells.
    Journal of virology, 2013, Volume: 87, Issue:22

    Topics: Animals; Antiviral Agents; Apoptosis; Blotting, Western; Cells, Cultured; Cidofovir; Cyclic AMP; Cytosine; Gammaherpesvirinae; Herpesviridae Infections; Humans; Kidney; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; NIH 3T3 Cells; Organophosphonates; Organophosphorus Compounds; Prodrugs; Tumor Virus Infections; Virus Activation; Virus Replication

2013