Compounds > organophosphonates
Page last updated: 2024-09-05

organophosphonates and cathepsin g

organophosphonates has been researched along with cathepsin g in 9 studies

Compound Research Comparison

Studies
(organophosphonates)		Trials
(organophosphonates)		Recent Studies (post-2010)
(organophosphonates)		Studies
(cathepsin g)		Trials
(cathepsin g)		Recent Studies (post-2010) (cathepsin g)
9,9688803,5961,14010231

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's5 (55.56)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Charlton, J; Kirschenheuter, GP; Smith, D1
Hamilton, RJ; Healy, A; Martin, SL; Walker, B; Walker, BJ; Wharry, S1
Almond, HR; Andrade-Gordon, P; Chattopadhyay, D; Corcoran, TW; de Garavilla, L; Greco, MN; Hawkins, MJ; Kauffman, JA; Maryanoff, BE; Powell, ET; Recacha, R1
Andrade-Gordon, P; Chen, ZW; Corcoran, TW; Damiano, BP; de Garavilla, L; Derian, CK; Di Cera, E; Eckardt, AJ; Giardino, EC; Greco, MN; Haertlein, BJ; Kauffman, JA; Maryanoff, BE; Mathews, FS; Pineda, AO; Sukumar, N; Wells, GI1
Almond, HR; Cantwell, AM; Corcoran, TW; Damiano, BP; de Garavilla, L; Di Cera, E; Greco, MN; Hall, J; Hawkins, MJ; Maryanoff, BE; Minor, LK; Powell, ET; Savvides, SN; Wang, Y1
Legowska, A; Lesner, A; Oleksyszyn, J; Pietrusewicz, E; Rolka, K; Sieńczyk, M; Wysocka, M1
Abraham, WM; Andrade-Gordon, P; de Garavilla, L; Greco, MN; Haertlein, BJ; Maryanoff, BE; Wells, GI1
Burchacka, E; Gorodkiewicz, E; Grzywa, R; Laudański, P; Lesner, A; Sieńczyk, M; Łukaszewski, Z1
Chung, JH; Jang, JH; Kim, YK; Kusumaningrum, N; Lee, DH; Oh, JH; Shin, CY1

Other Studies

9 other study(ies) available for organophosphonates and cathepsin g

ArticleYear
Highly potent irreversible inhibitors of neutrophil elastase generated by selection from a randomized DNA-valine phosphonate library.
    Biochemistry, 1997, Mar-11, Volume: 36, Issue:10

    Topics: Cathepsin G; Cathepsins; Fluorescein; Fluoresceins; Fluorescence; Gene Library; Humans; Kinetics; Leukocyte Elastase; Models, Chemical; Molecular Conformation; Neutrophils; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Organophosphonates; Salts; Sequence Analysis; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Valine

1997
Asymmetric preference of serine proteases toward phosphonate and phosphinate esters.
    Biochemical and biophysical research communications, 2000, Oct-05, Volume: 276, Issue:3

    Topics: Cathepsin G; Cathepsins; Child; Chymotrypsin; Cystic Fibrosis; Humans; Hydrolysis; Isomerism; Kinetics; Leukocyte Elastase; Organophosphonates; Phosphinic Acids; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity

2000
Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design.
    Journal of the American Chemical Society, 2002, Apr-17, Volume: 124, Issue:15

    Topics: Cathepsin G; Cathepsins; Drug Design; Models, Molecular; Organophosphonates; Protein Conformation; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship

2002
A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
    The Journal of biological chemistry, 2005, May-06, Volume: 280, Issue:18

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cathepsin G; Cathepsins; Chymases; Crystallography, X-Ray; Humans; Leukocytes; Male; Mast Cells; Organophosphonates; Peritonitis; Piperidines; Pulmonary Disease, Chronic Obstructive; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Serine Proteinase Inhibitors

2005
Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase.
    Journal of medicinal chemistry, 2007, Apr-19, Volume: 50, Issue:8

    Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Biological Availability; Cathepsin G; Cathepsins; Chymases; Cricetinae; Crystallography, X-Ray; Humans; Mast Cells; Models, Molecular; Naphthalenes; Organophosphonates; Phosphinic Acids; Rats; Serine Endopeptidases; Stereoisomerism; Structure-Activity Relationship

2007
New potent cathepsin G phosphonate inhibitors.
    Bioorganic & medicinal chemistry, 2008, Oct-01, Volume: 16, Issue:19

    Topics: Amino Acid Sequence; Binding, Competitive; Cathepsin G; Cathepsins; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Organophosphonates; Protease Inhibitors; Radioligand Assay; Serine Endopeptidases; Structure-Activity Relationship; Substrate Specificity

2008
Dual inhibition of cathepsin G and chymase is effective in animal models of pulmonary inflammation.
    American journal of respiratory and critical care medicine, 2010, Feb-01, Volume: 181, Issue:3

    Topics: Animals; Biomarkers; Bronchoalveolar Lavage Fluid; Cathepsin G; Chymases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Injections, Intravenous; Lung Diseases; Mice; Organophosphonates; Piperidines; Pulmonary Disease, Chronic Obstructive; Rats; Sheep; Treatment Outcome

2010
Determination of cathepsin G in endometrial tissue using a surface plasmon resonance imaging biosensor with tailored phosphonic inhibitor.
    European journal of obstetrics, gynecology, and reproductive biology, 2014, Volume: 182

    Topics: Adult; Binding Sites; Cathepsin G; Endometriosis; Endometrium; Female; Humans; Molecular Conformation; Organophosphonates; Protein Binding; Surface Plasmon Resonance; Young Adult

2014
Topical treatment with a cathepsin G inhibitor, β-keto-phosphonic acid, blocks ultraviolet irradiation-induced basement membrane damage in hairless mouse skin.
    Photodermatology, photoimmunology & photomedicine, 2019, Volume: 35, Issue:3

    Topics: Administration, Topical; Animals; Basement Membrane; Cathepsin G; Mice; Mice, Hairless; Organophosphonates; Skin; Skin Aging; Ultraviolet Rays

2019