organophosphonates has been researched along with aminopterin in 2 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (aminopterin) | Trials (aminopterin) | Recent Studies (post-2010) (aminopterin) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 1,389 | 73 | 109 |
| Protein | Taxonomy | organophosphonates (IC50) | aminopterin (IC50) |
|---|---|---|---|
| Dihydrofolate reductase | Homo sapiens (human) | 0.0201 | |
| Dihydrofolate reductase | Mus musculus (house mouse) | 0.0253 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.005 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.011 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Forsch, RA; Freisheim, JH; Kohler, W; Moran, RG; Rosowsky, A | 1 |
| Clarke, L; Rosowsky, A; Waxman, DJ | 1 |
2 other study(ies) available for organophosphonates and aminopterin
| Article | Year |
|---|---|
Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition.
Topics: Aminopterin; Animals; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Mice; Organophosphonates; Peptide Synthases; Structure-Activity Relationship; Sulfonic Acids | 1988 |
Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs.
Topics: Amines; Aminopterin; Folic Acid Antagonists; Humans; Kinetics; Liver; Methotrexate; Organophosphonates; Peptide Synthases; Structure-Activity Relationship; Sulfonic Acids | 1987 |