organophosphonates has been researched along with adenine in 3853 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (adenine) | Trials (adenine) | Recent Studies (post-2010) (adenine) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 21,903 | 1,153 | 7,682 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (0.91) | 18.7374 |
| 1990's | 266 (6.90) | 18.2507 |
| 2000's | 1546 (40.12) | 29.6817 |
| 2010's | 1961 (50.90) | 24.3611 |
| 2020's | 45 (1.17) | 2.80 |
| Authors | Studies |
|---|---|
| Balzarini, J; Bergamini, A; Calio, R; De Clercq, E; Milanese, G; Pauwels, R; Perno, CF; Rocchi, G; Yarchoan, R | 1 |
| Andrei, G; Cloes, JM; De Clercq, E; Piette, J; Rentier, B; Sadzot-Delvaux, C; Schols, D; Snoeck, R | 1 |
| Andrei, G; De Clercq, E; Desmyter, J; Goubau, P; Snoeck, R | 1 |
| Cerny, J; Cheng, YC; Foster, SA | 2 |
| Awan, AR; de la Fuente, R; Field, HJ | 2 |
| Hitchcock, MJ; Mansuri, MM; Martin, JC; Starrett, JE; Tortolani, DR | 1 |
| Ebner, JP; Hoover, EA; Philpott, MS | 1 |
| Beer, B; Donath, A; Egberink, HF; Hartmann, K; Hoffmann-Fezer, G; Horzinek, MC; Lutz, H; Thefeld, S; Thum, I | 1 |
| Cronn, RC; North, TW; Preston, BD; Remington, KM | 1 |
| Camacho Sánchez, MA; Torres Suárez, AI | 1 |
| Cihlár, T; Herve, TY; Holý, A; Jindrich, J; Merta, A; Otmar, M; Rosenberg, I; Votruba, I | 1 |
| Alberts, DE; Gallion, HH; Hynes, HE; Liu, PY; Mills, G; O'Sullivan, J; O'Toole, RV; Smith, HO | 1 |
| Comis, RL; Nash, SL; O'Dwyer, PJ; Ozols, RF; Perez, RP | 1 |
| Alberts, DS; Craig, JB; Hannigan, EV; Liu, PY; Malviya, VK; Surwit, EA | 1 |
| Balzarini, J; De Clercq, E; Naesens, L | 4 |
| De Clercq, E; Maudgal, PC | 2 |
| Andrei, G; De Clercq, E; Neyts, J; Schols, D; Snoeck, R | 1 |
| De Castro, LM; De Clercq, E; Gangemi, JD; Ghaffar, A; Kern, ER; Mayer, EP; Vogt, PE | 1 |
| Ebner, JP; Hoover, EA; Mullins, JI; Zeidner, NS | 1 |
| Balzarini, J; De Clercq, E | 2 |
| Egberink, HF; Hartman, K; Horzinek, MC | 1 |
| Cerný, J; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Sedivá, K; Veselý, J; Vlach, J; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Hao, Z; Herdewijn, P; Johns, DG | 1 |
| Balzarini, J; De Clercq, E; Dvorakova, H; Hao, Z; Herdewijn, P; Holy, A; Jindrich, J; Johns, DG; Snoeck, R | 1 |
| Broder, S; Kageyama, S; Mitsuya, H; Yarchoan, R | 1 |
| Balestra, E; Balzarini, J; Calio, R; De Clercq, E; Del Gobbo, V; Foli, A; Marini, S; Perno, CF; Villani, N | 1 |
| Araullo-Cruz, T; De Clercq, E; Erzurum, S; Gordon, YJ; Romanowski, E; Seaberg, L; Tolman, R | 1 |
| Balzarini, J; De Clercq, E; Palú, G; Parolin, C; Rassu, M; Stefanelli, S | 1 |
| Bonnet, JD; Braun, TJ; Crowley, J; Hanson, KH; Keppen, M; Salmon, SE | 1 |
| Abbruzzese, JL; Ajani, JA; Bradof, JE; Daugherty, K; Levin, B; Linke, K; Pazdur, R; Winn, R | 1 |
| Craig, JB; Crawford, ED; Goodman, P; Higano, CS; Kish, JA; Rivkin, SE; Wolf, M | 1 |
| Depisch, D; Dittrich, C; Gisslinger, H; Haider, K; Kornek, G; Linkesch, W; Scheithauer, W | 1 |
| Klunk, LJ; Marrero, D; Russell, JW; Starrett, JE; Whiterock, VJ | 1 |
| De Clercq, E | 17 |
| Baba, M; De Clercq, E; Konno, K; Shigeta, S; Yokota, T | 1 |
| Berger, MZ; Dimaggio, JJ; Gralla, RJ; Heelan, RT; Kris, MG; Marks, LD; Potanovich, LM | 1 |
| Chavalitshewinkoon, P; de Clercq, E; de Vries, E; Franssen, FF; Nieuwenhuijs, H; Overdulve, JP; Stam, JG; van der Vliet, PC | 1 |
| Balzarini, J; Bronson, R; De Clercq, E; Jaenisch, R; Lee, JS; Mullaney, S; Ruprecht, RM; Sharpe, AH | 1 |
| Berezin, F; Janisch, L; Mick, R; Ratain, MJ; Schilsky, RL; Smiddy, J; Williams, SF | 1 |
| Diasio, RB; Stagg, MP | 1 |
| Benvenuto, JA; Beran, M; Estey, E; Felder, TB; Keating, M; O'Brien, S | 1 |
| Comis, RL; Hudes, GR; O'Dwyer, PJ; Ozols, RF; Paul, AR; Walczak, J | 1 |
| Balzarini, J; De Clercq, E; Holý, A; Naesens, L; Niphuis, H; Rosenberg, I; Schellekens, H; Slachmuylders, J | 1 |
| Bronson, JJ; De Boeck, H; Ghazzouli, I; Hitchcock, MJ; Ho, HT; Martin, JC; Woods, K | 1 |
| De Clercq, E; Konno, K; Mochizuki, S; Mori, S; Shigeta, S; Yokota, T | 1 |
| Depisch, D; Haider, K; Kornek, G; Scheithauer, W | 1 |
| Ayoub, J; Cormier, Y; Eisenhauer, EA; Evans, WK; Laberge, F; Shepherd, FA; Wierzbicki, R | 1 |
| Balzarini, J; De Clercq, E; Gangemi, JD; Ghaffar, A; Mayer, E; Mayer, R; Midoux, P; Monsigny, M; Negre, E; Roche, AC | 1 |
| Balzarini, J; Borst, M; De Clercq, E; Egberink, H; Horzinek, M; Koolen, M; Neu, H; Niphuis, H; Schellekens, H | 1 |
| Kim, CU; Luh, BY; Martin, JC | 1 |
| Holý, A; Merta, A; Rosenberg, I; Veselý, J; Votruba, I | 2 |
| Awan, AR; Field, HJ | 2 |
| Bernaerts, R; Holý, A; Hrebabecký, H; Merta, A; Otmar, M; Rosenberg, I; Votruba, I | 1 |
| Cerný, J; Holý, A; Otmar, M; Rosenberg, I; Vonka, V; Votruba, I | 1 |
| Balzarini, J; Bron, D; De Clercq, E; Delforge, A; Lagneaux, L; Snoeck, R; Stryckmans, P; Van der Auwera, P | 1 |
| Anisimová, E; Cerný, J; Holý, A; Rosenberg, I; Vonka, V; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Naesens, L; Sobis, H; Vandeputte, M | 1 |
| Brian, EL; De Clercq, E; Pagano, JS; Smith, MS | 1 |
| Balzarini, J; Cozens, RM; De Clercq, E; Gangemi, JD; Hochkeppel, HK | 1 |
| Arteaga, CL; Brown, TD; Craig, JB; Harman, GS; Havlin, KA; Koeller, JM; Kuhn, JG; Von Hoff, DD; Weiss, GR | 1 |
| Azuma, M; Sakuma, T | 1 |
| Craig, JB; Hardy, J; Harman, G; Havlin, K; Koeller, J; Kuhn, JG; Melink, TJ; Phillips, J; Saez, R; Weiss, GR | 1 |
| Hsiang, YH; Jiang, JB; Liu, LF | 1 |
| De Clercq, E; Mul, YM; van der Vliet, PC; van Miltenburg, RT | 1 |
| De Clercq, E; Holý, A; Rosenberg, I | 1 |
| Lemmer, B | 1 |
| Feun, LG; Hsu, TC; Liang, J; Lu, K; Savaraj, N | 1 |
| Bernaerts, R; De Clercq, E; Holý, A; Merta, A; Rosenberg, I; Sakuma, T; Votruba, I | 1 |
| DeClercq, E; Lin, JC; Pagano, JS | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Desmyter, J; Holy, A; Pauwels, R; Rosenberg, I; Schols, D | 1 |
| Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Holy, A; Johns, DG; Naesens, L; Pauwels, R; Rosenberg, I | 1 |
| Andersson, BS; Bakic, M; Beran, M; Newman, RA; Silberman, LE; Zwelling, LA | 1 |
| Baba, M; De Clercq, E; Konno, K; Shigeta, S | 1 |
| Ajani, JA; Baker, FL; Spitzer, G | 1 |
| Lu, K; McLean, MA; Newman, RA; Vestal, ML | 1 |
| Malspeis, L; Ratain, MJ; Schilsky, RL; Staubus, AE | 1 |
| Arzuza, O; De Clercq, E; García-Villalón, D; Gil-Fernández, C; Tabarés, E | 1 |
| De Clercq, E; Gil-Fernández, C | 1 |
| Baba, M; De Clercq, E; Mori, S; Shigeta, S | 1 |
| De Clercq, E; Groen, J; Osterhaus, AD | 1 |
| Felder, TB; Krakoff, IH; Legha, SS; Newman, RA; Raber, M; Ring, S | 1 |
| Holý, A; Rosenberg, I | 1 |
| Kroschel, DM; Moore, DJ; Powis, G | 1 |
| Lu, K; Newman, RA; Savaraj, N | 1 |
| Danenberg, PV; Montgomery, KA; Santi, DV | 1 |
| Braña, MF; García Gancedo, A; Gil-Fernández, C; Paez, E; Pérez, S; Rodriguez, F; Roldán, CM; Vilas, P | 1 |
| Braña, MF; Garcá Gancedo, A; Gil-Fernández, C; Paez, E; Perez, S; Rodriguez, F; Roldán, CM; Vilas, P | 1 |
| Braña, MF; Cañete, M; Stockert, JC | 1 |
| Chen, MS; Cherrington, JM; Foli, A; Gu, Z; Mulato, AS; Salomon, H; Sogocio, KM; Wainberg, MA; Yarchoan, R | 1 |
| McCarthy, M | 1 |
| Cohen, J | 8 |
| Beck, TW; Benveniste, RE; Bischofberger, N; Black, R; Follis, KE; Grant, RF; Sabo, A; Tsai, CC | 1 |
| Balestra, E; Balzarini, J; Caliò, R; De Clercq, E; Del Gobbo, V; Holy, A; Perno, CF; Sesa, F; Villani, N | 1 |
| Gelbic, I; Marec, F | 1 |
| Bischofberger, N; Follis, KE; Grant, R; Sabo, A; Tsai, CC | 1 |
| Buckner, JC; Burch, PA; Cascino, TL; Gallagher, JG; Goldberg, RM; Levitt, R; Morton, RF; O'Fallon, JR; Scheithauer, BW; Westberg, MW | 1 |
| Balzarini, J | 1 |
| Cihlár, T; Holý, A; Rosenberg, I; Votruba, I | 1 |
| Alberts, DS; Dorr, RT; Remers, WA; Sami, SM; Sólyom, AM | 2 |
| Balzarini, J; De Clercq, E; Goebels, J; Hatse, S; Sobis, H; Vandeputte, M; Verstuyf, A | 1 |
| Aduma, P; Connelly, MC; Fridland, A; Srinivas, RV | 1 |
| Balzarini, J; De Clercq, E; Georgsson, G; Naesens, L; Pálsson, PA; Thormar, H; Torsteinsdóttir, S | 1 |
| Ashton, RJ; Bailey, S; Harnden, MR; Jackson, SM; Serafinowska, HT; Sutton, D | 1 |
| Burris, HA; Eckardt, JR; Fields, S; O'Rourke, T; Rodriguez, GI; Rothenberg, ML; Weiss, GR | 1 |
| De Clercq, E; Kaminsky, R; Zweygarth, E | 1 |
| Balzarini, J; de Clercq, E; de Wilde, GA; Heijtink, RA; Kruining, J; Schalm, SW | 1 |
| Günther Sillero, MA; Guranowski, A; Sillero, A; Starzyńska, E | 1 |
| de Vries, E; Franssen, FF; Janse, CJ; Overdulve, JP; Smeijsters, LJ; Zijlstra, NM | 1 |
| Balestra, E; Balzarini, J; Caliò, R; De Clercq, E; Del Gobbo, V; Fabrizi, E; Perno, CF; Villani, N | 1 |
| Franková, D; Holý, A; Otová, B; Votruba, I; Zídek, Z | 1 |
| Capranico, G; De Isabella, P; Zunino, F | 1 |
| Connelly, MC; Fridland, A; Marshall, DR; Robbins, BL; Srinivas, RV | 1 |
| Allen, SL; Costanza, M; Henderson, IC; Ratain, MJ; Rosner, G; Schilsky, RL; Van Echo, DA | 1 |
| De Clercq, E; Neyts, J | 3 |
| Bauman, A; Benson, AB; Blough, RR; Carroll, RB; French, SL; Kilton, LJ; Mullane, MR; Schilsky, RL; Wade, JL | 1 |
| Holý, A; Kren, V; Krenová, D; Otová, B; Votruba, I; Zídek, Z | 1 |
| Cundy, KC; Fishback, JA; Lee, ML; Lee, WA; Shaw, JP; Soike, KF; Visor, GC | 1 |
| Ahmann, F; Blumenstein, B; Craig, JB; Crawford, ED; Eisenberger, M; Marshall, ME; Thompson, IM | 1 |
| Fridland, A; Gong, YF; Marshall, DR; Srinivas, RV | 1 |
| Hitchcock, MJ; Mansuri, MM; Martin, JC; Russell, J; Starrett, JE; Tortolani, DR; Whiterock, V | 1 |
| Camacho, MA; Gil, ME; Obregón, MM; Ruz, V; Torres, AI | 1 |
| Mimura, Y; Naito, T; Nitta, K; Shiota, H | 1 |
| Balcerzak, SP; Buys, SS; Metch, B; Neefe, JR; Stuckey, WJ | 1 |
| Mick, R; Ratain, MJ | 1 |
| Bartz, C; Benveniste, RE; Bischofberger, N; Follis, KE; Grant, RF; Nolte, RE; Sabo, A; Tsai, CC | 1 |
| Asbury, RF; Blessing, JA; Soper, JT | 1 |
| Holý, A; Kren, V; Otová, B; Sladká, M; Votruba, I | 1 |
| Blazek, K; Holý, A; Otová, B; Schramlová, J; Sladká, M; Votruba, I | 1 |
| Bílá, V; Holý, A; Jelínek, R; Kren, V; Mejsnarová, B; Otová, B; Sladká, M | 1 |
| Cundy, KC; Lee, WA; Shaw, JP | 1 |
| Burch, PA; Kovach, JS; Marschke, RF; O'Connell, MJ; Rubin, J; Schutt, AJ; Wieand, HS | 1 |
| Depisch, D; Dittrich, C; Fazeny, B; Haider, K; Kornek, G; Raderer, M; Scheithauer, W | 1 |
| Elleder, D; Elleder, M; Kren, V; Otová, B; Panczak, A; Sladká, M | 1 |
| Bousquet, P; Braña, MF; Castellano, JM; Emling, F; Keilhauer, G; Morán, M; Pérez de Vega, MJ; Qian, XD; Romerdahl, CR; Schlick, E | 1 |
| Asbury, RF; Blessing, JA; Clarke-Pearson, D; Homesley, HD; Look, KY | 1 |
| Bischofberger, N; Connelly, MC; Fridland, A; Gong, YF; Robbins, BL; Srinivas, RV | 1 |
| Elleder, D; Elleder, M; Holý, A; Kren, V; Otová, B; Panczak, A | 1 |
| Aubertin, AM; Gosselin, G; Imbach, JL; Kirn, A; Lefebvre, I; Pompon, A; Puech, F | 1 |
| Holý, A; Merta, A; Stĕtina, R; Votruba, I | 1 |
| Alberts, DS; Craig, JB; Liu, PY; Malviya, VK; O'Sullivan, J; O'Toole, R; Rosenoff, S; Surwit, E; Ward, JH; Yu, A | 1 |
| Balzarini, J; Berk, L; De Clercq, E; De Wilde, GA; Heijtink, RA; Holy, A; Kruining, J; Schalm, SW | 1 |
| Conrad, ME; Eisenberg, P; Fisher, RI; Fleming, T; MacDonald, JS; Poplin, E | 1 |
| Benvenuto, JA; Johnston, DA; Nishioka, K | 1 |
| Brown, GA; Field, HJ; Gilliam, SE; Thackray, AM | 1 |
| Ebbert, LP; Foley, JF; Gesme, DH; Hatfield, AK; Jett, JR; Krook, JE; Mailliard, JA; Maksymiuk, AW; Schreffler, DD; Su, JQ | 1 |
| Brown, TD; Craig, JB; Einstein, AB; Fleming, T; Goodman, PJ; Macdonald, JS | 1 |
| Berezin, F; Janisch, L; Lane, LB; Mick, R; Ratain, MJ; Schilsky, RL; Vogelzang, NJ | 1 |
| Barditch-Crovo, P; Collier, AC; Cundy, KC; Ebeling, D; Jaffe, HS; Toole, J; Walker, RE | 1 |
| De Clercq, E; Huyghe, P; Maudgal, PC | 1 |
| Braña, MF; Castellano, JM; Emling, F; Klebe, G; Kluge, M; Morán, M; Schlick, E; Walker, N | 1 |
| Aquaro, S; Balzarini, J; De Clercq, E; Holý, A; Perno, CF; Witvrouw, M | 1 |
| Franková, D; Holý, A; Otová, B; Zídek, A | 1 |
| Blum, R; Bonomi, P; Chang, AY; Smith, JL; Smith, TJ; Tu, ZN; Wiernik, PH | 1 |
| Connelly, MC; Fridland, A; Greenhaw, J; Robbins, BL | 1 |
| Folks, TM; Sandstrom, PA | 1 |
| Brun, R; DeClercq, E; Grether, Y; Holý, A; Kaminsky, R; Naesens, L; Schmid, C | 1 |
| Balzarini, J; De Clercq, E; Dvoráková, H; Holý, A; Naesens, L; Reymen, D | 1 |
| Abushanab, E; El-Subbagh, HI; Panzica, RP; Racha, S; Vargeese, C; Vemishetti, P | 1 |
| Akerman, S; Allen, SL; Budman, DR; Calabro, A; Chan, K; Fusco, D; Hock, K; Kreis, W; Mittelman, A; Puccio, C; Spigelman, M | 1 |
| Aquaro, S; Balestra, E; Balzarini, J; Calio, R; Cenci, A; Di Pierro, D; Lazzarino, G; Panti, S; Perno, CF; Tavazzi, B | 1 |
| Ahmed, PS; Brennan, TM; Bridges, CG; Casara, P; Hornsperger, JM; Navé, JF; Taylor, DL; Tyms, AS | 1 |
| Allen, SJ; Chen, MS; Cherrington, JM; Fuller, MD; Kunder, SC; Lesnikowski, Z; Mulato, AS; Schinazi, RF; Sommadossi, JP; Ussery, MA | 1 |
| Benson, AB; Blough, R; French, S; Kies, M; Kilton, LJ; Lad, T; Mullane, M; Rosen, F; Vokes, EE; Wade, J | 1 |
| Bear, S; Remers, WA | 1 |
| Balzarini, J; Bischofberger, N; De Clercq, E; Naesens, L | 1 |
| Dorrestein, GM; Franssen, FF; Hermsen, RC; Nieuwenhuijs, H; Overdulve, JP; Smeijsters, LJ | 1 |
| De Clercq, E; Kodama, E; Shigeta, S; Suzuki, T | 1 |
| Berezin, F; Janisch, L; Kut, M; Mick, R; Ratain, MJ; Schilsky, RL; Vogelzang, NJ | 1 |
| Arends, S; Kamp, W; Schokker, J; van Halteren, E | 1 |
| Konno, K; Shigeta, S; Sudo, K; Yokota, T | 1 |
| Andrei, G; De Clercq, E; Snoeck, R | 2 |
| Chen, MS; Cherrington, JM; Fuller, MD; Mulato, AS | 1 |
| Anderson, B; Cherrington, JM; Foli, A; Gu, Z; Kavlick, M; Mitsuya, H; Saville, MW; Sogocio, KM; Wainberg, MA; Yarchoan, R | 1 |
| Balzarini, J; De Clercq, E; Hatse, S | 3 |
| Berardi, CJ; Bischofberger, N; Canfield, DR; Cherrington, JM; Marthas, ML; Mulato, AS; Pedersen, NC; Spinner, A; Tarara, RP; Telm, S; Van Rompay, KK | 1 |
| de Clercq, E; De Hauwere, B; Lutz, A; Maudgal, PC; Neyts, J | 1 |
| Aubertin, AM; Benzaria, S; Gosselin, G; Imbach, JL; Johnson, R; Maury, G; Obert, G; Pélicano, H | 1 |
| Kennedy, MJ | 1 |
| Aquaro, S; Balestra, E; Balzarini, J; Caliò, R; Cenci, A; Di Pierro, D; Garaci, E; Grimaldi, S; Lazzarino, G; Perno, CF; Santoro, N; Tavazzi, B | 1 |
| Balzarini, J; Casara, P; De Clercq, E; Egberink, H; Hartmann, K; Navé, JF; Pannecouque, C; Vahlenkamp, T; Witvrouw, M | 1 |
| Casara, P; Foresman, L; Joag, SV; Li, Z; Narayan, O; Navé, JF; Pinson, DM; Raghavan, R; Stephens, EB | 1 |
| Annaert, P; Augustijns, P; de Clercq, E; Kinget, R; Naesens, L | 1 |
| Elson, P; Hsieh, P; Oken, MM; Trump, DL; Witte, RS | 1 |
| Beck, TW; Bischofberger, N; Dailey, PJ; Follis, KE; Sabo, A; Tsai, CC | 1 |
| Arimilli, MN; Bidgood, AM; Cundy, KC; Jones, RJ; Krishnamurthy, VV; Lee, WA; Louie, MS; Shaw, JP | 1 |
| Adams, GL; Dutcher, JP; Leaf, AN; Neuberg, D; Ritch, PS; Schwartz, EL; Wadler, S | 1 |
| Connelly, MC; Fridland, A; Lee, SH; Pisarev, VM | 1 |
| Connely, M; Fridland, A; Srinivas, RV | 1 |
| Barditch-Crovo, P; Cundy, KC; Ebeling, D; Hendrix, CW; Jaffe, HS; Lietman, PS; Toole, J | 1 |
| Franková, D; Holý, A; Zídek, Z | 3 |
| Bischofberger, N; Fauci, AS; Hirsch, VM; Kinter, A; Lifson, JD; Lloyd, AL; Nowak, MA; Vasquez, GM; Wahl, LM; Williams, J; Wiltrout, TA | 1 |
| Asbury, R; Blessing, JA; Buller, R; Look, KY; Lucci, JA | 1 |
| Cherrington, JM; Collier, A; Deeks, SG; Drew, WL; Hellmann, N; Jaffe, HS; Kahn, J; Lalezari, J; Lamy, PD; Li, W; Mulato, AS; Pavia, A; Rodrigue, D; Toole, J | 1 |
| Cundy, KC; Lee, WA; Marshburn, J; Nakamura, C; Shaw, JP; Sue, IL; Visor, GC | 1 |
| Cherrington, JM; Mulato, AS | 1 |
| Chen, MS; Cherrington, JM; Flores, C; Fuller, MD; Mendel, DB; Moon, K; Mulato, AS; Xiong, X | 1 |
| Arimilli, MN; Cundy, KC; Kim, CU; Lee, WA; Oliyai, R; Shaw, JP; Sueoko, CM | 1 |
| Balzarini, J; Erfle, V; Goebel, F; Goldberg, M; Hartmann, K; Kuffer, M; Rolinski, B | 1 |
| Balzarini, J; Bischofberger, N; De Clercq, E; Erfle, V; Goebel, FD; Goldberg, M; Hartmann, K; Holy, A; Jindrich, J; Kraft, W; Kuffer, M; Naesens, L | 1 |
| Gale, KC; Hsiung, Y; Nitiss, JL; Osheroff, N; Rose, A; Zhou, J | 1 |
| Bischofberger, N; Fridland, A; Kim, C; Robbins, BL; Srinivas, RV | 1 |
| Cundy, KC; Griffin, L; Lee, WA; Lynch, GR; Shaw, JP; Sueoka, C | 1 |
| Annaert, P; Augustijns, P; Benzaria, S; de Clercq, E; Gosselin, G; Hatse, S; Imbach, JL; Kinget, R; Naesens, L; Pompon, A; Valette, G; Van den Mooter, G | 1 |
| Asbury, R; Blessing, JA; Buller, R; Malfetano, JH; Sevin, BU; Walker, J | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L | 3 |
| Beck, TW; Benveniste, RE; Bischofberger, N; Emau, P; Follis, KE; Lifson, JD; Morton, WR; Tsai, CC | 1 |
| Balzarini, J; De Clercq, E; Degrève, B; Hatse, S; Naesens, L; Segers, C; Vandeputte, M; Waer, M | 1 |
| Bijsterbosch, MK; Smeijsters, LJ; van Berkel, TJ | 1 |
| Bílá, V; Holý, A; Lesková, V; Mejsnarová, B; Otová, B; Sladká, M; Votruba, I | 1 |
| Balzarini, J; De Clercq, E; Degrève, B; Hatse, S; Naesens, L; Vandeputte, M; Waer, M | 1 |
| Fridland, A; Srinivas, RV | 1 |
| Asbury, R; Ball, H; Blessing, JA; Podczaski, E | 1 |
| Agatep, E; Berardi, CJ; Bischofberger, N; Cundy, KC; Dehqanzada, ZA; Lifson, JD; Marthas, ML; Pedersen, NC; Van Rompay, KK; Vasquez, GM | 1 |
| Anton, KE; Cherrington, JM; Hellmann, NS; Lamy, PD; Li, WX; Miller, MD; Mulato, AS | 1 |
| Holý, A; Kaminsky, R; Nickel, B | 1 |
| Aguirre, NL; Berardi, CJ; Bischofberger, N; Lietman, PS; Marthas, ML; Pedersen, NC; Van Rompay, KK | 1 |
| Cherrington, JM; Cihlar, T; Fuller, MD; Lamy, PD; Margot, NA; Miller, MD; Mulato, AS | 1 |
| Baba, M; De Clercq, E; Makino, M; Okada, Y; Suruga, Y; Tanaka, H | 1 |
| Asbury, R; Blessing, JA; McGuire, WP; Reid, GC | 1 |
| Barditch-Crovo, P; Cundy, KC; Deeks, SG; Hellmann, NS; Hwang, F; Kahn, JO; Lietman, PS; Rooney, JF; Safrin, S | 1 |
| Johnson, KA; Suo, Z | 1 |
| Berkowitz, I; Berry, D; Costanza, ME; Duggan, D; Henderson, IC; Kalra, J; Lyss, AP; Ratain, MJ; Shapiro, C; Wu, K | 1 |
| Flores, C; Gibbs, CS; Toole, JJ; Xiong, X; Yang, H | 1 |
| Angus, PW; Colledge, DL; Locarnini, SA; Nicoll, AJ; Smallwood, RA; Toole, JJ | 1 |
| Anton, KE; Cherrington, JM; Lamy, PD; Miller, MD; Mulato, AS | 1 |
| Black, RJ | 1 |
| Havel, J; Holý, A; Revilla, A; Vargas, G | 1 |
| Endová, M; Liboska, R; Pressová, M; Rosenberg, I; Toĉík, Z | 1 |
| Balzarini, J; De Clercq, E; Georgsson, G; Gunnarsson, E; Naesens, L; Thormar, H; Torsteinsdóttir, S | 1 |
| Aguirre, NL; Bischofberger, N; Canfield, DR; Cherrington, JM; Dailey, PJ; Lamy, PD; Marthas, ML; Pedersen, NC; Tarara, RP; van Rompay, KK | 1 |
| Cundy, KC | 1 |
| Bischofberger, N; Cundy, K; Marthas, ML; Shaw, JP; Tarantal, AF | 1 |
| Bischofberger, N; Canfield, DR; Cherrington, JM; Dailey, PJ; Lamy, PD; Marthas, ML; Pedersen, NC; Tarara, RP; Van Rompay, KK | 1 |
| Berry, DA; Cirrincione, C; Costanza, ME; Frei, E; Henderson, IC; McIntyre, OR; Norton, L; Schilsky, RL; Weiss, RB; Winer, E; Wood, WC | 1 |
| Gibbs, CS; Rooney, JF; Toole, JJ; Tsiang, M | 1 |
| Cheng, YC; Fu, L; Liu, SH | 1 |
| Carrilho, FJ; Kato, N; Lan, KH; Omata, M; Ono-Nita, SK; Shiratori, Y; Yoshida, H | 1 |
| Balzarini, J; de Clercq, E; de Vries, E; Franssen, FF; Holý, A; Naesens, L; Overdulve, JP; Smeijsters, LJ | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Schols, D | 1 |
| Dailey, P; Dandekar, S; Mattapallil, JJ; Smit-McBride, Z | 1 |
| Baggett, TH; Gracia Jones, S | 1 |
| Birkus, G; Holý, A; Otová, B; Votruba, I | 1 |
| Merigan, TC; Palmer, S; Shafer, RW | 1 |
| Annaert, P; Augustijns, P; De Clercq, E; Kinget, R; Naesens, L; Van den Mooter, G; Van Gelder, J | 1 |
| Cihlar, T; Fuller, MD; Lin, DC; Mendel, DB; Pritchard, JB; Sweet, DH | 1 |
| Biessen, EA; Bijsterbosch, MK; de Vrueh, RL; Rump, ET; Sliedregt, LA; van Berkel, TJ | 1 |
| Connelly, MC; Flynn, PM; Fridland, A; Kumar, A; Paibir, SG; Schuetz, JD; Srinivas, RV; Sun, D | 1 |
| Annaert, P; Augustijns, P; Bridger, G; De Clercq, E; Henson, G; Kinget, R; Naesens, L; Pannecouque, C; Shafiee, M; Van den Mooter, G; Van Gelder, J; Witvrouw, M | 1 |
| Goa, KL; Noble, S | 1 |
| Crowe, S | 1 |
| Collier, AC; Schwartz, MA | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L; Segers, C; Verbeken, E; Waer, M | 1 |
| Downey, KM; Kramata, P | 1 |
| Gosselin, G; Johnson, RA; Laux, WH; Périgaud, C; Shoshani, I | 1 |
| Chopra, KB; Gilson, RJ; Jaffe, HS; Murray-Lyon, IM; Nelson, MR; Newell, AM; Rice, SJ; Tedder, RS; Toole, J; Weller, IV | 1 |
| Angarano, G | 1 |
| Gibbs, CS; Howard, T; Jacobsmeyer, S; Lamy, P; Murray, A; Peters, MG; Singer, G; Xiong, X | 1 |
| Bischofberger, N; Bogers, WM; Heeney, JL; Kuhn, EM; Nieuwenhuis, IG; Niphuis, H; Rosenwirth, B; ten Haaft, P; Uberla, K | 1 |
| Aguirre, NL; Bischofberger, N; Canfield, DR; Cherrington, JM; Dailey, PJ; Margot, NA; Marthas, ML; Miller, MD; Pedersen, NC; Tarara, RP; Van Rompay, KK | 1 |
| Beijnen, JH; Hoetelmans, RM; Sparidans, RW; Veldkamp, A | 1 |
| Balzarini, J; Biessen, EA; Bijsterbosch, MK; de Vrueh, RL; Rump, ET; van Berkel, TJ; van De Bilt, E; van Veghel, R | 1 |
| Civitico, G; Colledge, D; Locarnini, S; Shaw, T | 1 |
| Anton, KE; Cherrington, JM; Lamy, PD; Margot, NA; Miller, MD; Mulato, AS; Quan, Y; Salomon, H; Wainberg, MA | 1 |
| Boucher, CA; Cambridge, E; De Groot, T; De Jong, S; Kamp, W; Schokker, J; Schuurman, R | 1 |
| Arnaout, R; Bischofberger, N; Coalter, VJ; Fisher, B; Flynn, BM; Hirsch, VM; Imming, RJ; Kiser, RF; Li, L; Lifson, JD; Nowak, MA; Parks, TL; Piatak, M; Rossio, JL; Schneider, DK; Walsh, G; Wodarz, D | 1 |
| Erhardt, A; Häussinger, D; Heintges, T; Petry, W | 1 |
| Cihlar, T; Ho, ES; Lin, DC; Mendel, DB | 1 |
| De Clercq, E; Neyts, J; Ying, C | 1 |
| Blanchard, S; Burchett, S; Coakley, DF; Culnane, M; Cundy, KC; Fridland, A; Hughes, WT; Purdue, L; Read, JS; Rodman, JH; Shenep, JL; Willoughby, R; Zimmer, B | 1 |
| de Vries, E; Heuvel, C; Overdulve, JP; Smeijsters, LJ; Veenstra, J; Verstrepen, BE; Zijlstra, NM | 1 |
| De Clercq, E; Furman, P; Neyts, J; Nicholson, W; Ying, C | 1 |
| Freiman, JS; McCaughan, GW | 1 |
| Bischofberger, N; Crabbs, C; Greenhouse, J; Jiang, JB; Lewis, MG; Racz, K; Racz, P; Silvera, P; Yalley-Ogunro, J | 1 |
| Brosgart, CL; Israelski, DM; Katzenstein, DA; Miller, MD; Murlidharan, U; Passaro, DJ; Shafer, RW; Shulman, NS; Van Doren, S; Zolopa, AR | 1 |
| Self, SG; Wick, D | 1 |
| Gutfreund, K; Hirsch, K; Lamy, P; Murray, A; Perrillo, R; Schiff, E; Statler, A; Wright, T; Yoshida, E | 1 |
| Burda, MR; Dandri, M; Petersen, J; Will, H | 1 |
| Warner, D | 1 |
| Annaert, P; Augustijns, P; de Clercq, E; Kinget, R; Naesens, L; Tukker, JJ; van Den Mooter, G; van Gelder, J | 1 |
| Leung, N | 3 |
| Abrahams, PJ; Biessen, EA; Bijsterbosch, MK; De Vrueh, RL; Prince, P; Sliedregt, LA; Valentijn, AR; Van Berkel, TJ; Van Boom, JH; Van De Bilt, E; Van Der Marel, GA | 1 |
| Cihlar, T; Ho, ES; Mulato, AS | 1 |
| Adams, DR; Butera, S; Folks, TM; Jackson, E; Jaffe, H; Janssen, R; Kim, CN; Otten, RA; Pullium, JK; Smith, DK | 1 |
| Acosta, E; Cheng, H; Fischl, M; Fiscus, SA; Fletcher, CV; Freimuth, W; Gulick, RM; Haubrich, R; Hu, XJ; Katzenstein, D; Lagakos, SW; Mills, C; Pettinelli, C; Snyder, S; Swanstrom, R | 1 |
| Folkers, G; Pautsch, A; Perozzo, R; Pilger, B; Prota, A; Scapozza, L; Schelling, P; Schulz, GE; Vogt, J | 1 |
| Hoffman, VF; Skiest, DJ | 1 |
| Adany, I; Bischofberger, N; Buch, S; Foresman, L; Li, Z; Lifson, JD; Lopez, GJ; Narayan, O; Page, A; Smith, MS; Tsay, J; Wang, C; Wodarz, D | 1 |
| Boyle, BA | 2 |
| Beck, TW; Bischofberger, N; Emau, P; Follis, KE; Morton, WR; Sun, JC; Tran, CA; Tsai, CC | 1 |
| Dahl, TC; Oliyai, R; Yuan, LC | 2 |
| Crabbs, C; Greenhouse, J; Lewis, MG; Lisziewicz, J; Lori, F; Silvera, P; Tinelli, C; Varga, G; Wagner, W; Xu, J; Yalley-Ogunro, J; Zinn, DE | 1 |
| Annaert, P; Augustijns, P; De Clercq, E; Deferme, S; Kinget, R; Naesens, L; Van den Mooter, G; Van Gelder, J | 1 |
| Acosta, EP; Cheng, H; Fischl, M; Fletcher, CV; Gulick, RM; Haubrich, R; Hu, XJ; Katzenstein, D; Mills, C; Raasch, R; Remmel, RP | 1 |
| Innocenti, F; Iyer, L; Ratain, MJ | 2 |
| Bischofberger, N; Brown, CR; Buckler-White, A; Endo, Y; Hirsch, V; Igarashi, T; Martin, MA; Plishka, R | 1 |
| Hatse, S | 1 |
| Bischofberger, N; Buch, S; Foresman, L; Kumar, A; Lifson, JD; Narayan, O | 1 |
| Bischofberger, N; Dittmer, U; Heeney, J; Hunsmann, G; Lorenzen, D; Ràcz, P; Spring, M; Stahl-Hennig, C; Stolte, N; Tenner-Ràcz, K | 1 |
| Regev, A; Schiff, ER | 1 |
| Bricaire, F; Dominguez, S | 1 |
| Aguesse-Germon, S; Jamard, C; Pichoud, C; Seignères, B; Trépo, C; Vuillermoz, I; Zoulim, F | 1 |
| Lagakos, SW; Weinberg, JM | 1 |
| Grande Santamaría, L; Romero Gómez, M; Suárez García, E | 1 |
| Alberts, DS; Dorr, RT; Hersh, EM; Liddil, JD; Remers, W; Sami, SM | 1 |
| Arnold, E; Das, K; Gibbs, CS; Sarafianos, SG; Westland, CE; Xiong, X; Yang, H | 1 |
| Ballatore, C; Balzarini, J; De Clercq, E; McGuigan, C | 1 |
| Smart, T | 1 |
| Cheng, B | 1 |
| Cadman, J | 2 |
| Schouten, J | 1 |
| Lau, GK | 2 |
| Balestra, E; Brandi, G; Cappellacci, L; Franchetti, P; Grifantini, M; Magnani, M; Perno, CF; Rossi, L; Schiavano, GF; Serafini, S | 1 |
| Holý, A; Kampf, G; Kapinos, LE; Lippert, B; Lüth, MS; Müller, J; Sigel, H | 1 |
| Delaney, WE; Locarnini, S; Shaw, T | 1 |
| Werle, B; Zoulim, F | 1 |
| Aguirre, NL; Bischofberger, N; Marthas, ML; McChesney, MB; Schmidt, KA; Van Rompay, KK | 1 |
| Bell, A; D'agati, VD; Kambham, N; Markowitz, GS; Tanji, K; Tanji, N | 1 |
| Bock, T; Chin, R; Furman, P; Isom, H; Locarnini, S; Manns, M; Shaw, T; Sozzi, V; Torresi, J; Trautwein, C | 1 |
| Biessen, EA; Bijsterbosch, MK; de Clercq, E; de Vrueh, RL; Neyts, J; van Berkel, TJ; Ying, C | 1 |
| Chalifoux, L; Chen, ZW; Enimi, EA; Gastron, M; Henckler, B; Letvin, NL; Miller, M; Sehgal, N; Sehgal, P; Shen, L; Shen, Y; Simon, M; Zhou, D | 1 |
| Alexander, GJ; Bloor, S; Lamy, P; Walsh, KM; Wight, DG; Woodall, T | 1 |
| Anton, KE; Cherrington, JM; Fuller, MD; Lamy, PD; Margot, NA; Miller, MD; Mulato, AS | 1 |
| Buckheit, R; Gilbert, H; Margot, N; Miller, M; Palmer, S; Shaw, N | 1 |
| Alston, B; Brosgart, CL; Chaloner, K; Cohn, DL; El-Sadr, WM; Fisher, EJ; Grant, LB; Sampson, J; Schmetter, B | 1 |
| Benhamou, Y; Bochet, M; Brosgart, C; Calvez, V; Fievet, MH; Fry, J; Gibbs, CS; Katlama, C; Namini, H; Poynard, T; Thibault, V; Vig, P | 1 |
| Barditch-Crovo, P; Coakley, DF; Coleman, RL; Collier, A; Deeks, SG; Kahn, JO; Kearney, BP; Lamy, PD; Lietman, PS; McGowan, I; Miller, M; Safrin, S | 1 |
| Brown, C; Cullen, JM; Cundy, KC; Eisenberg, EJ; Gibbs, C; Li, DH; Toole, J; Wolfe, J | 1 |
| Gilden, D | 1 |
| James, JS | 6 |
| Miller, MD; Naeger, LK | 1 |
| Carr, A; Chuah, J; Cooper, DA; Doong, N; French, M; Hoy, J; Hudson, J; Law, M; Mallal, S; Smith, D | 1 |
| Bischofberger, N; Coalter, V; Czajak, S; Desrosiers, RC; Fisher, B; Flynn, BM; Ghrayeb, J; Hirsch, VM; Kiser, R; Li, L; Lifson, JD; Nowak, MA; Parks, T; Piatak, M; Reimann, KA; Rossio, JL; Schmitz, JE; Wodarz, D | 1 |
| Miller, DS | 1 |
| Murono, S; Pagano, JS; Raab-Traub, N | 1 |
| Barditch-Crovo, P; Coakley, DF; Collier, A; Deeks, SG; McGowan, I; Miller, M; Smith, A | 1 |
| Cane, P; Feraz-Neto, BH; Harrison, R; Mutimer, D; O'Donnell, K; Pillay, D; Shaw, J | 1 |
| Huff, B | 1 |
| Schwetz, BA | 1 |
| de Man, RA; Niesters, HG; Wolters, LM | 1 |
| Gazzard, BG | 2 |
| Ansari, AA; Bostik, P; Brice, GT; June, CH; Mayne, AE; Mori, K; Villinger, F | 1 |
| Delmas, J; Gibbs, C; Hantz, O; Jamard, C; Schorr, O; Trépo, C; Zoulim, F | 1 |
| Thompson, CA | 1 |
| Ramrakhiani, S; Sponseller, CA | 1 |
| Perrillo, RP | 2 |
| Birkus, G; Cihlar, T; Hitchcock, MJ | 1 |
| Pujol, G; Williams, K | 1 |
| Giles, C | 1 |
| Bischofberger, N; Castillo, A; Ekert, JE; Martin, RB; Tarantal, AF | 1 |
| Birkus, G; Cihlar, T; Greenwalt, DE; Hitchcock, MJ | 1 |
| Brumme, ZL; Harrigan, PR; Larder, BA; McKenna, P; Miller, MD | 1 |
| Bestman-Smith, J; Boivin, G | 1 |
| Boyer, N; Castelneau, C; Marcellin, P | 1 |
| Benhamou, Y; Bochet, MV; Bombled, T; Calvez, V; Delaugerre, C; Katlama, C; Marcelin, AG; Peytavin, G; Thibault, V | 1 |
| Birkus, G; Hájek, M; Holý, A; Kramata, P; Otová, B; Votruba, I | 1 |
| Brown, TD; Craig, JB; Jaeckle, K; Rankin, C; Solank, DL; Taylor, SA; Townsend, JJ; Vance, RB | 1 |
| Burda, JV; Dostál, L; Kopecký, V; Mojzes, P | 1 |
| Polk, B | 1 |
| Cheng, AK; Isaacson, E; Margot, NA; McGowan, I; Miller, MD; Schooley, RT | 1 |
| Beall, G; Berger, D; Chen, SS; Cheng, AK; Isaacson, E; Lampiris, H; Miller, MD; Myers, RA; Ruane, P; Schooley, RT | 1 |
| Margot, NA; Miller, MD; Naeger, LK | 1 |
| Julander, JG; Morrey, JD; Sidwell, RW | 1 |
| Coull, JJ; Drusano, GL; Hossain, MM; Margolis, DM | 1 |
| Huengsberg, M; Palfreeman, A | 1 |
| Bendele, RA; Richardson, FC | 1 |
| Aberg, JA; Bennett, KK; Bessen, LJ; Brosgart, C; DeGruttola, V; Eron, JJ; Gulick, RM; Hammer, SM; Holohan, MK; Karol, CN; Lewis, RH; Mellors, JW; Mitsuyasu, RT; Rogers, MD; Saah, AJ; Sheiner, L; Vaida, F; Valentine, FT; Wheat, LJ | 1 |
| Augustijns, P; De Clercq, E; Deferme, S; Kinget, R; Naesens, L; van den Mooter, G; van Gelder, J | 1 |
| Feinberg, J | 3 |
| Brosgart, C; Delaney, WE; Fry, J; Gibbs, CS; Heathcote, EJ; Ho, V; Miller, MD; Westland, CE; Xiong, S; Yang, H | 1 |
| Berg, T; Schürmann, D; van Bömmel, F; Wünsche, T | 1 |
| Gallant, JE | 2 |
| Cappellacci, L; Casabianca, A; Celeste, AG; Cerasi, A; Chiarantini, L; Dominici, S; Franchetti, P; Grifantini, M; Magnani, M; Rossi, L; Serafini, S | 1 |
| Davis, GL | 1 |
| Dusak, BA; Goodwin, SD; Kuritzkes, DR; Rooney, JF; Skowron, G; Squires, KE; Stevens, M; Thompson, MA; Tolson, JM; Yuen, GJ | 1 |
| Prescott, LM | 1 |
| Hussar, DA | 1 |
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| Terrault, NA | 2 |
| Gazzard, B; Mandalia, S; Pillay, D; Pozniak, A; Winston, A | 1 |
| Andrei, G; De Clercq, E; Dewolf-Peeters, C; Holý, A; Snoeck, R; Van Den Oord, J | 1 |
| Shere-Wolfe, KD; Verley, JR | 1 |
| Bates, M; Chappey, C; Hellmann, NS; Maroldo, L; Parkin, N; Petropoulos, CJ | 1 |
| Bischofberger, N; Lawson, JR; Marthas, ML; Schmidt, KA; Singh, R; Van Rompay, KK | 1 |
| Carnevali, A; Casabianca, A; Franchetti, P; Magnani, M; Orlandi, C; Rossi, L; Schiavano, GF; Serafini, S | 1 |
| Dieterich, DT | 1 |
| Balzarini, J; Van Herrewege, Y; Vanham, G | 1 |
| McClellan, MB | 1 |
| Alcaide, ML; Jayaweera, D; Kolber, M | 1 |
| Díaz, B; González-Lahoz, J; Núñez, M; Pérez-Olmeda, M; Ríos, P; Soriano, V | 1 |
| Zoulim, F | 4 |
| Marcellin, P | 2 |
| Aberg, JA; Crippin, J; Kessels, L; Lisker-Melman, M; Powderly, WG; Ristig, MB; Tebas, P | 1 |
| Fouqueray, B; Girard, PM; Meynard, JL; Monge, M; Mougenot, B; Ronco, P; Rossert, J; Verhelst, D | 1 |
| Fung, HB; Piacenti, FJ; Stone, EA | 1 |
| Castillo, AB; Martin, RB; Tarantal, AF; Watnik, MR | 1 |
| Atkins, M; Barr, A; Bower, M; Fisher, M; Gazzard, B; Matthews, G; Nelson, M; Pillay, D; Portsmouth, S; Stebbing, J | 1 |
| Eagan, L | 1 |
| Coca, S; Perazella, MA | 1 |
| Bowden, S; Chen, RY; Colledge, D; Delaney, WE; Desmond, P; Edwards, R; Isom, H; Locarnini, SA; Shaw, T | 1 |
| Higgins, J; Huang, VY; Matthews, TB; Murry, JP; North, TW; Pedersen, NC; Van Rompay, KK | 1 |
| Benhamou, Y; Thibault, V; Tubiana, R | 1 |
| Antoniou, T; Park-Wyllie, LY; Tseng, AL | 1 |
| Fisher, DA; Huffam, SE | 1 |
| Boarino, V; Gelmini, R; Grottola, A; Lama, NG; Villa, E | 1 |
| Barg-Hock, H; Becker, T; Bleck, JS; Bock, CT; Böker, KH; Flemming, P; Klempnauer, J; Manns, MP; Rosenau, J; Tillmann, HL; Trautwein, C | 1 |
| Jullien, V; Pons, G; Rey, E; Tréluyer, JM | 1 |
| Berg, T; Hopf, U; Schernick, A; Van Bömmel, F | 1 |
| Birkus, G; Cihlar, T; Gibbs, CS | 1 |
| McColl, DJ; Miller, MD | 1 |
| Chevallier, M; Cova, L; Gibbs, CS; Guerret, S; Jamard, C; Le Guerhier, F; Thermet, A; Trépo, C; Zoulim, F | 1 |
| Brosgart, CL; Chang, TT; Fry, J; Goodman, Z; Hadziyannis, SJ; Heathcote, EJ; Kitis, G; Lim, SG; Marcellin, P; Rizzetto, M; Tassopoulos, NC; Wulfsohn, MS; Xiong, S | 1 |
| Brosgart, CL; Chang, TT; Fry, J; Goodman, Z; Jeffers, L; Lim, SG; Marcellin, P; Shiffman, ML; Sievert, W; Tong, MJ; Wulfsohn, MS; Xiong, S | 1 |
| Gollan, JL; Mailliard, ME | 1 |
| Burroughs, AK; Papatheodoridis, GV; Sevastianos, V | 1 |
| Kern, ER | 1 |
| Hadziyannis, SJ; Papatheodoridis, GV; Vassilopoulos, D | 1 |
| Fontana, RJ | 1 |
| Benhamou, Y; Bernard-Chabert, B; Poynard, T; Ratziu, V; Thabut, D; Thibault, V | 1 |
| Bruno, R; Ciappina, V; Filice, G; Puoti, M; Sacchi, P; Zocchetti, C | 1 |
| Créput, C; Gonzalez-Canali, G; Hill, G; Kazatchkine, M; Nochy, D; Piketty, C | 1 |
| Bakshi, KK; Chen, J; Condra, JH; Danovich, RM; DiNubile, MJ; Graham, DJ; Haas, DW; Holder, DJ; Rhodes, RR; Saah, AJ; Shivaprakash, M | 1 |
| Brun, S; Di Mascio, M; Ho, DD; Hogan, C; Hurley, A; Louie, M; Markowitz, M; Perelson, AS; Rooney, J; Ruiz, N; Simon, V; Sun, E | 1 |
| Bourgarit, A; Droz, D; Furco, A; Karras, A; Lafaurie, M; Legendre, C; Martinez, F; Molina, JM; Sereni, D | 1 |
| Chou, S; Murphy, MD; O'Hearn, M | 1 |
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| Boyer, N; Castelnau, C; Marcellin, P | 1 |
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| Belinsky, MG; Chen, ZS; Guo, Y; Hopper-Borge, E; Kotova, E; Kruh, GD; Lee, K | 1 |
| Abbott, B; Bendele, R; Biesecker, G; Desjardins, J; Karimi, S; Meyer, D; Richardson, F | 1 |
| Grim, SA; Romanelli, F | 1 |
| Chen, XY; Yang, HY; Zhang, Y; Zhao, LY; Zhong, DF | 1 |
| Bacheler, L; Erickson-Viitanen, S; Gallagher, K; Garber, S; Geleziunas, R; Otto, MJ; Schinazi, RF; Shi, G; Wu, JT; Zhang, H | 1 |
| Cheng, A; Isaacson, E; Margot, NA; McGowan, I; Miller, MD | 1 |
| Beijnen, JH; Crommentuyn, KM; Schellens, JH; Sparidans, RW | 1 |
| Mukherjee, S | 1 |
| Chung, C; Coakley, D; Di Mascio, M; Flaherty, J; Hogan, C; Hurley, A; Lamy, P; Louie, M; Markowitz, M; Padte, N; Perelson, AS; Simon, V | 1 |
| Fridland, A; Robbins, BL; Rodman, JH; Wilcox, CK | 1 |
| Hitchcock, MJ; Holý, A; Keith, KA; Kern, ER; Lee, WA | 1 |
| Brosgart, CL; Delaney, WE; Fry, J; Gibbs, CS; Miller, MD; Westland, CE; Wulfsohn, M; Xiong, S; Yang, H | 1 |
| Mallal, S; Nolan, D | 1 |
| Bock, CT; Dienes, HP; Klein, C; Kubicka, S; Locarnini, S; Manns, MP; Trautwein, C; Wedemeyer, H; Wüstefeld, T | 1 |
| Brosgart, C; Chen, SS; Delaney, W; Fry, J; Gibbs, C; Gish, R; Hadziyannis, S; Marcellin, P; Miller, M; Westland, C; Xiong, S; Yang, H | 1 |
| Callens, S; Colebunders, R; De Schacht, C; Huyst, V | 1 |
| Vere Hodge, A | 2 |
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| Bill, R; Cohen, D; Fisher, A; Grasso, C; Mayer, KH; Mimiaga, MJ; Van Derwarker, R | 1 |
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| de la Loma, GA; Mateos Lindemann, M; Moreira Vicente, V; Rodríguez Dominguez, M | 1 |
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| Brown, RS; Enejosa, J; McGuire, BM; Ramanathan, S; Schiff, E; Terrault, NA; Tran, TT; Tupper, R; Zhong, L; Zong, J | 1 |
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| Buti, M; Elefsiniotis, I; Esteban, R; Jardi, R; Vezali, E | 1 |
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| Barr, JR; Cong, ME; Garcia-Lerma, JG; Heneine, W; Holder, A; Kuklenyik, Z; Martin, A; Pau, CP; Pirkle, JL; Youngpairoj, AS; Zheng, Q | 1 |
| Chetty, K; Connolly, JO; Edwards, SG; Hall, AM; Lapsley, M; O'Farrell, S; Unwin, RJ; Williams, IG | 1 |
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| Chen, X; Ji, R; Liu, J; Lu, P; Wang, Y; Yang, Y | 1 |
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| Byun, KS; Choe, WH; Hong, SP; Ji, SI; Jung, YK; Kim, BK; Kim, JH; Kim, KH; Kim, SO; Ko, SY; Kwon, SY; Lee, CH; Yeon, JE | 1 |
| Amuron, B; Birungi, J; Bunnell, R; Coutinho, A; Foster, S; Grosskurth, H; Jaffar, S; Kyomuhangi, R; Levin, J; Mermin, J; Nabiryo, C; Namara, G; Ndembi, N; Opio, A; Tappero, JW | 1 |
| Collier, AC; Daar, ES; Farajallah, A; Fischl, MA; Geiseler, PJ; Godfrey, C; Ha, B; Jahed, NC; Johnson, VA; Katzenstein, D; Koletar, SL; Mollan, K; Myers, L; Peeples, L; Rooney, JF; Sax, PE; Tierney, C; Woodward, WC | 1 |
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| Cheng, AK; Cohen, C; DeJesus, E; Gallant, JE; Liu, HC; Mills, A; Plummer, A; Rhee, MS; Sax, PE; Szwarcberg, J; White, KL; Wohl, D; Zolopa, A | 1 |
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| Booth, M; Dennis, DM; Derendorf, H; Gonzalez, D; Melker, RJ; Morey, TE; Quinn, B; van der Straten, A; Wasdo, S; Wishin, J | 1 |
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| Gao, Y; Li, L; Ma, K; Pang, Z; Qian, S; Wei, Y; Zhang, J; Zheng, D | 1 |
| Davies, DW; Diao, Y; Kafle, P; Khasbaatar, A; Punjani, S; Sanghavi, R | 1 |
| Tang, F; Wei, M; Wu, X; Zhang, J; Zhang, M; Zhou, Y | 1 |
| Chayanupatkul, M; Dilokthornsakul, P; Permsuwan, U; Sawangjit, R; Sriuttha, P; Sukeepaisarnjaroen, W; Tangkijvanich, P; Tanwandee, T | 1 |
| Kudose, S; Lunenfeld, E; Markowitz, GS | 1 |
| Bajpai, PS; Bukh, J; Dalegaard, MI; Fahnøe, U; Lundh, A; Ryom, L; Weis, N; Winckelmann, A | 1 |
| Kent, KM; Oliyai, R; Yang, T | 1 |
| Choudhary, MC; Mellors, JW | 1 |
| Dieterich, D; Roediger, R; Smyth, EK | 1 |
| Sigel, A; Sigel, H; Sigel, RKO | 1 |
| Alfaro, EM; Arazo, P; Arellano, JP; Arribas, JR; Bachiller, P; Buzón, L; Del Amo, J; Díaz de Santiago, A; Díaz-Brito, V; García Del Toro, M; García-Albéniz, X; Garcinuño, MA; Gómez-Sirvent, JL; Guerra, JM; Hernán, MA; Hernández-Torres, A; Hita, C; Martínez de Salazar, P; Masiá, M; Morales, M; Moreno, S; Muñoz, L; Polo, R; Rial-Crestelo, D; Santos, J; Sanz, J; Terán, C | 1 |
| Ahn, SH; Jung, CY; Kim, BS; Kim, HW; Kim, SU; Lee, HW; Lee, JI | 1 |
| Banerjee, S; Kumar, RK; Reddy, PY; Sanghvi, YS | 1 |
| Groaz, E; Herdewijn, P; Lescrinier, E; Rihon, J; Xu, Y | 1 |
| Hu, X; Li, Y; Luo, H; Qin, B; Tan, G | 1 |
| Baeten, JM; Bekker, LG; Cohen, MS; Corey, L; Delany-Moretlwe, S; Donnell, D; Edupuganti, S; Gao, F; Gray, G; Hanscom, B; Hosseinipour, M; Hughes, JP; Mgodi, N; Rees, H | 1 |
471 review(s) available for organophosphonates and adenine
| Article | Year |
|---|---|
Chemotherapy of feline immunodeficiency virus infection.
Topics: Adenine; Animals; Antiviral Agents; Cats; Feline Acquired Immunodeficiency Syndrome; Immunodeficiency Virus, Feline; Organophosphonates; Zidovudine | 1991 |
Targeted therapy of human immunodeficiency virus-related disease.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; CD4 Antigens; Didanosine; Dideoxynucleosides; Dipyridamole; Drug Synergism; Gene Expression Regulation, Viral; Genes, nef; Genes, rev; Genes, tat; HIV; HIV Protease; Interferon Type I; Organophosphonates; RNA-Directed DNA Polymerase; Stavudine; Transcription, Genetic; Zalcitabine; Zidovudine | 1991 |
Chemotherapy of the acquired immune deficiency syndrome (AIDS): acyclic nucleoside phosphonate analogues.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA, Viral; Humans; Organophosphonates; Organophosphorus Compounds | 1991 |
Broad-spectrum anti-DNA virus and anti-retrovirus activity of phosphonylmethoxyalkylpurines and -pyrimidines.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; DNA, Viral; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Virus Replication | 1991 |
Therapeutic potential of phosphonylmethoxyalkylpurines and -pyrimidines as antiviral agents.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Purines; Pyrimidines; Retroviridae Infections; Virus Diseases | 1990 |
Novel chemotherapeutic agents in early clinical development.
Topics: Adenine; Alkaloids; Anthraquinones; Antineoplastic Agents; Biphenyl Compounds; Camptothecin; Humans; Imides; Irinotecan; Isoquinolines; Naphthalimides; Neoplasms; Organophosphonates; Paclitaxel; Pyrazoles; Quinazolines; Sulfonylurea Compounds; Terpenes; Trimetrexate | 1990 |
Biochemical pharmacology of acyclic nucleotide analogues.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; HIV; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds | 1990 |
New anticancer agents.
Topics: Adenine; Antibiotics, Antineoplastic; Antineoplastic Agents; Biphenyl Compounds; Depsipeptides; Echinomycin; Epirubicin; Flavonoids; Guanidines; Humans; Idarubicin; Imides; Isoquinolines; Menogaril; Naphthalimides; Nogalamycin; Organophosphonates; Pentostatin; Peptides, Cyclic; Polymers; Vidarabine Phosphate | 1988 |
New acquisitions in the development of anti-HIV agents.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Dideoxynucleosides; Drug Design; HIV; Molecular Structure; Organophosphonates; Polysaccharides; Purines | 1989 |
Virus-drug resistance: thymidine kinase-deficient (TK-) mutants of herpes simplex virus. Therapeutic approaches.
Topics: Acyclovir; Adenine; Antiviral Agents; Drug Resistance, Microbial; Herpes Simplex; Humans; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Thymidine Kinase; Viral Proteins | 1987 |
Anti-retroviral and pharmacological properties of 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Topics: Adenine; Adenylate Kinase; Animals; Antiviral Agents; Biotransformation; Herpesviridae; Humans; Muscle, Skeletal; Organophosphonates; Phosphorylation; Phosphotransferases; Rabbits; Retroviridae; Structure-Activity Relationship | 1994 |
New anticancer agents.
Topics: Adenine; Animals; Antineoplastic Agents; Camptothecin; Deoxycytidine; Gemcitabine; Humans; Imides; Indoles; Irinotecan; Isoquinolines; Naphthalimides; Organophosphonates; Pyridines; Topotecan; Vinblastine; Vinorelbine | 1994 |
New strategies for treating AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiviral Agents; Capsid; Drug Design; Drug Resistance, Microbial; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Viral Core Proteins; Virus Replication; Zinc Fingers | 1996 |
The potential of acyclic nucleoside phosphonates as broad-spectrum antiviral agents.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Herpesviridae Infections; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections; Stereoisomerism | 1995 |
Metastatic breast cancer.
Topics: Adenine; Antibodies, Monoclonal; Antibodies, Neoplasm; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Bone Neoplasms; Breast Neoplasms; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Deoxycytidine; Diphosphonates; Docetaxel; Doxorubicin; Enzyme Inhibitors; Female; Gemcitabine; Humans; Imides; Intercalating Agents; Isoquinolines; Naphthalimides; Neoplasm Metastasis; Neoplasm Proteins; Organophosphonates; Paclitaxel; Randomized Controlled Trials as Topic; Salvage Therapy; Taxoids; Topoisomerase II Inhibitors; Treatment Outcome | 1996 |
Acyclic nucleoside phosphonates in the chemotherapy of DNA virus and retrovirus infections.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Cidofovir; Cytosine; DNA Virus Infections; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections | 1997 |
Animal studies of prophylaxis.
Topics: Adenine; Animals; Anti-HIV Agents; Disease Models, Animal; Drug Administration Schedule; Interferon-alpha; Lentivirus Infections; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 1997 |
Clinical pharmacokinetics of the antiviral nucleotide analogues cidofovir and adefovir.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytosine; Drug Interactions; Humans; Infusions, Intravenous; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Insufficiency | 1999 |
Clinical update: new drugs for HIV/AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; Chemistry, Pharmaceutical; Cyclopropanes; Dideoxynucleosides; Drug Approval; Furans; HIV Protease Inhibitors; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Sulfonamides | 1999 |
Adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Microbial; Humans; In Vitro Techniques; Organophosphonates; Placebos; Prodrugs; Reverse Transcriptase Inhibitors | 1999 |
New reverse transcriptase inhibitors.
Topics: Adenine; Alkynes; Benzoxazines; Cyclopropanes; Delavirdine; Dideoxynucleosides; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Nevirapine; Organophosphonates; Oxazines; Prodrugs; Reverse Transcriptase Inhibitors; Soman; Uracil | 1999 |
Strategies for second-line antiretroviral therapy in adults with HIV infection.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Drug Therapy, Combination; HIV; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Virus Latency; Virus Replication | 1999 |
Coming therapies: adefovir.
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple; HIV Infections; HIV-1; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 1999 |
[New developments in therapy of chronic hepatitis B. When are nucleoside analogs indicated?].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver Transplantation; Long-Term Care; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2000 |
Current limitations to nucleoside analogue therapy for chronic hepatitis B virus infection in the liver transplant and non-transplant settings.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; DNA, Viral; Famciclovir; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Organophosphonates; Treatment Outcome | 2000 |
Nucleoside analogues in the treatment of chronic hepatitis B.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Deoxycytidine; Emtricitabine; Famciclovir; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2000 |
Therapeutic developments in cytomegalovirus retinitis.
Topics: Adenine; Antibodies, Monoclonal; Antiviral Agents; Cidofovir; Cytomegalovirus Retinitis; Cytosine; Drugs, Investigational; Foscarnet; Ganciclovir; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Thionucleotides; Valganciclovir | 2000 |
Pharmacogenetics: a tool for individualizing antineoplastic therapy.
Topics: Adenine; Antineoplastic Agents; Camptothecin; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Genotype; Glucuronosyltransferase; Humans; Imides; Irinotecan; Isoquinolines; Mercaptopurine; Methyltransferases; Naphthalimides; Organophosphonates; Oxidoreductases; Pharmacogenetics; Phenotype | 2000 |
Drug therapy for hepatitis B.
Topics: Adenine; Antiviral Agents; Disease Progression; Female; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Transplantation; Male; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors | 2001 |
Hepatitis B infection in China.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; China; Deoxycytidine; DNA, Viral; Drug Therapy, Combination; Drugs, Chinese Herbal; Emtricitabine; Famciclovir; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Thymosin | 2001 |
Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation.
Topics: 2-Aminopurine; Adenine; Amino Acid Sequence; Animals; Anti-HIV Agents; Antimetabolites; Antiviral Agents; Biological Availability; Cell Line; Clinical Trials as Topic; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Drug Design; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Viral; Drug Therapy, Combination; Enzyme Inhibitors; Famciclovir; Gene Products, pol; Hepatitis B; Hepatitis B virus; Hepatitis Viruses; Hepatitis, Animal; HIV; Humans; Lamivudine; Models, Animal; Molecular Sequence Data; Molecular Structure; Nucleosides; Organophosphonates; Sequence Alignment; Sequence Homology, Amino Acid; Species Specificity; Virus Replication | 2001 |
[Current knowledge on chronic hepatitis B therapy].
Topics: Adenine; Antiviral Agents; Drug Resistance, Microbial; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2001 |
Mechanisms of HIV-1 nucleoside reverse transcriptase inhibitor resistance: is it all figured out?
Topics: Adenine; Adenosine Triphosphate; Anti-HIV Agents; Drug Resistance, Microbial; HIV-1; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Stavudine; Tenofovir; Zidovudine | 2001 |
Nucleoside analogues for chronic hepatitis B.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Famciclovir; Ganciclovir; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2001 |
The potential place of tenofovir in antiretroviral treatment regimens.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Viral; HIV; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2001 |
Treatment of hepatitis B and C following liver transplantation.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Disease Progression; Drug Resistance; Drug Therapy, Combination; Hepatitis B; Hepatitis C; Humans; Immunoglobulins; Interferon-alpha; Lamivudine; Liver Transplantation; Organophosphonates; Prognosis; Ribavirin; Secondary Prevention; Survival Rate | 2002 |
How will we use the new antiviral agents for hepatitis B?
Topics: 2-Aminopurine; Adenine; Alanine Transaminase; Antiviral Agents; Drug Resistance; Drug Therapy, Combination; Famciclovir; Ganciclovir; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Mutation; Organophosphonates; Practice Guidelines as Topic | 2002 |
[New management strategies for hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B; Humans; Lamivudine; Organophosphonates | 2002 |
Adefovir dipivoxil. Bis-POM PMEA, GS 0840, GS 840, Piv2PMEA.
Topics: Adenine; Animals; Clinical Trials as Topic; Drug Industry; Hepatitis B, Chronic; HIV Infections; Humans; Organophosphonates | 2002 |
Update on the management of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2002 |
Prevention of recurrent hepatitis B post-liver transplantation.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Postoperative Complications; Reverse Transcriptase Inhibitors; Secondary Prevention; Viral Hepatitis Vaccines | 2002 |
Assessing hepatitis B virus resistance in vitro and molecular mechanisms of nucleoside resistance.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B virus; Humans; In Vitro Techniques; Lamivudine; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors | 2002 |
Advances in therapy for chronic hepatitis B.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2002 |
Tenofovir disoproxil fumarate: a nucleotide reverse transcriptase inhibitor for the treatment of HIV infection.
Topics: Adenine; Animals; Anti-HIV Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Hepatitis B; HIV Infections; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
Tenofovir: a nucleotide analog for the management of human immunodeficiency virus infection.
Topics: Adenine; Adenosine Monophosphate; Anti-HIV Agents; Biological Availability; HIV Infections; HIV-1; Humans; Inhibitory Concentration 50; Organophosphonates; Organophosphorus Compounds; Randomized Controlled Trials as Topic; Tenofovir; Treatment Outcome; Viral Load | 2003 |
Management of chronic hepatitis B virus infection in remote-dwelling Aboriginals and Torres Strait Islanders: an update for primary healthcare providers.
Topics: Adenine; Adolescent; Adult; Algorithms; Antiviral Agents; Australia; Carcinoma, Hepatocellular; Child; Child, Preschool; Clinical Protocols; Endemic Diseases; Female; Hepatitis B, Chronic; Humans; Infant; Infant, Newborn; Interferon-alpha; Lamivudine; Liver Neoplasms; Liver Transplantation; Male; Mass Screening; Middle Aged; Native Hawaiian or Other Pacific Islander; Organophosphonates; Primary Health Care; Rural Health Services | 2003 |
The use of tenofovir disoproxil fumarate for the treatment of nucleoside-resistant HIV-1.
Topics: Adenine; Drug Resistance, Viral; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Prevention of and treatment for hepatitis B virus infection after liver transplantation in the nucleoside analogues era.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Transplantation; Nucleosides; Organophosphonates; Postoperative Complications; Recurrence; Time Factors; Transplantation Immunology | 2003 |
In vitro activity of potential anti-poxvirus agents.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Humans; Mice; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Virus Replication | 2003 |
Treatment of HBeAg-negative chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Endpoint Determination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Inflammation; Interferon-alpha; Lamivudine; Liver Cirrhosis; Organophosphonates; Patient Care Planning; Prognosis; Reverse Transcriptase Inhibitors; Virus Replication | 2003 |
Management of patients with decompensated HBV cirrhosis.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Disease Progression; Drug Resistance; Hepatitis B; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; Risk Factors | 2003 |
Adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Interactions; Hepatitis B, Chronic; Humans; Organophosphonates; Treatment Outcome | 2003 |
[Treatment of hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Therapy, Combination; Hepatitis B; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Treatment Outcome | 2002 |
[Antiviral therapy for chronic viral hepatitis B and C].
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferon-beta; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Treatment Outcome | 2003 |
Tenofovir disoproxil fumarate.
Topics: Adenine; Animals; Clinical Trials as Topic; HIV Infections; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Thymidine analogue-sparing highly active antiretroviral therapy (HAART).
Topics: Adenine; Antiretroviral Therapy, Highly Active; Clinical Trials as Topic; Dideoxynucleosides; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-Associated Lipodystrophy Syndrome; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors | 2003 |
Slowing the progression of chronic hepatitis B. Early antiviral therapy can help minimize complications.
Topics: Adenine; Administration, Oral; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Child; Disease Progression; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Infant, Newborn; Interferons; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2003 |
Tenofovir disoproxil fumarate.
Topics: Adenine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Treatment Outcome | 2003 |
Effect of tenofovir on didanosine absorption in patients with HIV.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Area Under Curve; Clinical Trials as Topic; Didanosine; Drug Interactions; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Adefovir dipivoxil: a review of its use in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Organophosphonates | 2003 |
[Hepatitis: associated diseases. Risk groups -- prevention -- treatment].
Topics: Adenine; Adult; Antiviral Agents; Child; DNA, Viral; Female; Hepacivirus; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C; Hepatitis C, Chronic; Humans; Infant; Infant, Newborn; Interferons; Lamivudine; Liver Cirrhosis; Male; Mutation; Organophosphonates; Recurrence; Ribavirin; Risk Factors; RNA, Viral; Time Factors | 2003 |
Nucleoside analogues and other antivirals for treatment of hepatitis B in the peritransplant period.
Topics: Adenine; Antiviral Agents; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Nucleosides; Organophosphonates; Preoperative Care; Recurrence; Virus Replication | 2003 |
Early detection of hepatitis B drug resistance: implications for patient management.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2003 |
Current pharmacotherapy for the treatment of chronic hepatitis B.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Clinical Trials as Topic; Famciclovir; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Transplantation; Mutation; Nucleosides; Organophosphonates | 2003 |
Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections.
Topics: Adenine; Animals; Cidofovir; Cytosine; DNA Virus Infections; DNA Viruses; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Doctor to patient transmission of hepatitis B virus: implications of HBV DNA levels and potential new solutions.
Topics: Adenine; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Infectious Disease Transmission, Professional-to-Patient; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Physicians; Risk Factors; Risk Management; Tenofovir; Viral Load | 2003 |
Chronic viral hepatitis: always be current!
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Child; Female; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C; Humans; Immunization Schedule; Infant, Newborn; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Prevalence; Risk Factors; Serologic Tests; Treatment Outcome; United States; Viral Hepatitis Vaccines | 2003 |
[Application and efficacy of adefovir dipivoxil in hepatitis B virus-associated chronic liver diseases].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Liver Diseases; Organophosphonates | 2003 |
Viral hepatitis B.
Topics: Adenine; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Genotype; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Load | 2003 |
Rescue therapy for drug resistant hepatitis B: another argument for combination chemotherapy?
Topics: Adenine; Antiviral Agents; Drug Resistance, Microbial; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Salvage Therapy | 2004 |
Adefovir (Hepsera) for chronic hepatitis B infection.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Organophosphonates | 2003 |
Adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B: a review of the major clinical studies.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Organophosphonates; Randomized Controlled Trials as Topic | 2003 |
Combination therapy for chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Vaccines | 2003 |
Treatment of HBeAg negative chronic hepatitis B with new drugs (adefovir and others).
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates | 2003 |
Management of the patient with hepatitis B virus-related cirrhosis.
Topics: Adenine; Antiviral Agents; Hepatitis B; Humans; Interferons; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors | 2003 |
Treatment of chronic hepatitis B virus infection in patients co-infected with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Adefovir dipivoxil: a new antiviral agent for the treatment of hepatitis B virus infection.
Topics: Adenine; Animals; Antiviral Agents; Clinical Trials as Topic; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Male; Organophosphonates | 2003 |
Newer treatments for HIV in children.
Topics: Adenine; Anti-Bacterial Agents; Anti-HIV Agents; Child; Deoxycytidine; Didanosine; Drug Therapy, Combination; Emtricitabine; Enfuvirtide; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; Humans; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Peptide Fragments; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir | 2004 |
[Adefovir dipivoxil-A new drug for hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Hepatitis B; Humans; Organophosphonates | 2004 |
The continuing evolution of HIV therapy.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Carbamates; CD4 Lymphocyte Count; Cyclopropanes; Delayed-Action Preparations; Deoxycytidine; Didanosine; Dideoxynucleosides; Drug Monitoring; Emtricitabine; Furans; HIV Infections; Humans; Lamivudine; Nevirapine; Oligopeptides; Organophosphates; Organophosphonates; Organophosphorus Compounds; Oxazines; Pyridines; Randomized Controlled Trials as Topic; Stavudine; Sulfonamides; Tenofovir; Treatment Outcome; Viral Load; Zidovudine | 2003 |
Adefovir dipivoxil in the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Interactions; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; HIV Infections; Humans; Liver Transplantation; Organophosphonates; Randomized Controlled Trials as Topic | 2004 |
Metal ion complexes of antivirally active nucleotide analogues. Conclusions regarding their biological action.
Topics: Adenine; Adenine Nucleotides; Animals; Antiviral Agents; Drug Stability; Humans; Ions; Metals; Nucleotides; Organophosphonates; Structure-Activity Relationship; Substrate Specificity; Virus Replication | 2004 |
Tenofovir-related nephrotoxicity: case report and review of the literature.
Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adenine; Anti-HIV Agents; Clinical Chemistry Tests; Fanconi Syndrome; Female; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Time Factors; Treatment Outcome | 2004 |
Management of chronic hepatitis B in the HIV-infected patient.
Topics: Adenine; Algorithms; Antiviral Agents; Clinical Trials as Topic; Decision Trees; Drug Therapy, Combination; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
Editorial comment: HIV and HBV coinfection--a coming-of-age in treatment strategies.
Topics: Adenine; Antiviral Agents; Comorbidity; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Guanine; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
Fanconi's syndrome in HIV+ adults: report of three cases and literature review.
Topics: Adenine; Adult; Anti-Retroviral Agents; Bone Density; Calcitriol; Calcium; Fanconi Syndrome; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Phosphates; Tenofovir | 2004 |
[Adefovir dipivoxil is a new drug for treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Organophosphonates | 2004 |
Emtricitabine/tenofovir disoproxil fumarate.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Drugs, Investigational; Emtricitabine; Humans; Organophosphonates; Tenofovir | 2004 |
[New approaches in the treatment of hepatitis B].
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Contraindications; Deoxycytidine; Emtricitabine; Famciclovir; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Organophosphorus Compounds; Polyethylene Glycols; Prodrugs; Prognosis; Recombinant Proteins; Tenofovir; Zalcitabine | 2004 |
Molecular virology of hepatitis B virus.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Transcription, Genetic; Viral Proteins; Virus Replication | 2004 |
Hepatitis B virus kinetics and mathematical modeling.
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B; Hepatitis B virus; Hepatocytes; Lamivudine; Models, Biological; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Load; Virion | 2004 |
Treatment of patients with chronic hepatitis B with adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
Treatment with interferons (including pegylated interferons) in patients with hepatitis B.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2004 |
Management of hepatitis B in liver transplantation patients.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Immunization, Passive; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Organophosphonates; Reoperation; Secondary Prevention; Virus Replication | 2004 |
New treatment of chronic hepatitis B.
Topics: Adenine; Animals; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2004 |
Biochemical and mechanistic basis for the activity of nucleoside analogue inhibitors of HIV reverse transcriptase.
Topics: Adenine; Cytidine Triphosphate; Deoxycytidine; Deoxycytidine Monophosphate; Deoxyribonucleotides; Dioxolanes; DNA, Viral; Emtricitabine; HIV Infections; HIV Reverse Transcriptase; Humans; Kinetics; Molecular Structure; Nucleosides; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Protein Binding; Protein Conformation; Purine Nucleosides; Reverse Transcriptase Inhibitors; Substrate Specificity; Tenofovir; Zalcitabine | 2004 |
The role of interferon therapy in hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Hepatitis B; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Patient Selection; Practice Guidelines as Topic; Practice Patterns, Physicians'; Prognosis; Risk Assessment; Risk Factors; Treatment Outcome | 2004 |
Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics.
Topics: Adenine; Administration, Oral; Animals; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
K65R-associated virologic failure in HIV-infected patients receiving tenofovir-containing triple nucleoside/nucleotide reverse transcriptase inhibitor regimens.
Topics: Adenine; Clinical Trials as Topic; Dideoxynucleosides; Drug Interactions; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; Humans; Mutation; Organophosphonates; Prospective Studies; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure | 2004 |
Severe metabolic acidosis and renal failure in an HIV-1 patient receiving tenofovir.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adenine; HIV Infections; Humans; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prognosis; Reverse Transcriptase Inhibitors; Risk Assessment; Severity of Illness Index; Tenofovir | 2004 |
Current antiviral therapy for chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
Antiviral therapy for treatment-naïve hepatitis B virus patients.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
Treatment of hepatitis B virus infection in patients coinfected with HIV.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Antiviral therapy in patients with chronic hepatitis B and cirrhosis.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Organophosphonates | 2004 |
Hepatitis C virus in the setting of HIV or hepatitis B virus coinfection.
Topics: Adenine; Antiviral Agents; Comorbidity; Hepacivirus; Hepatitis B virus; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Proteins; Ribavirin; Risk Factors | 2004 |
[Treatment of chronic hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2004 |
[Hepatitis B (acute and chronic)].
Topics: Acute Disease; Adenine; Adolescent; Adult; Antiviral Agents; Child; Diagnosis, Differential; Drug Therapy, Combination; Follow-Up Studies; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; Risk Factors; Time Factors | 2004 |
[Antiviral treatment of chronic hepatitis B with adefovir dipivoxil].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Multicenter Studies as Topic; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
[Management of hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Child; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Infant, Newborn; Interferon-alpha; Lamivudine; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Time Factors | 2004 |
Treatment of chronic hepatitis B: who to treat, what to use, and for how long?
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
Potential of acyclic nucleoside phosphonates in the treatment of DNA virus and retrovirus infections.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Disease Models, Animal; DNA Virus Infections; Drug Resistance, Viral; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections; Tenofovir | 2003 |
Tenofovir disoproxil fumarate (Viread) for the treatment of HIV infection.
Topics: Adenine; Animals; Clinical Trials as Topic; HIV Infections; Humans; Organophosphonates; Tenofovir | 2003 |
Adefovir dipivoxil in the treatment of chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Approval; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Organophosphonates | 2004 |
Current therapies for chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Drug Resistance; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2004 |
Adefovir dipivoxil in chronic hepatitis B infection.
Topics: Adenine; Animals; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2004 |
Adefovir dipivoxil: review of a novel acyclic nucleoside analogue.
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; Drug Resistance, Viral; Hepatitis B, Chronic; HIV Infections; Humans; Organophosphonates; Treatment Outcome | 2004 |
Emerging treatments in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Combinations; Drug Resistance, Viral; Drug Therapy; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Recombinant Proteins; Vaccines | 2004 |
Treatment of chronic viral hepatitis.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis D, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2004 |
The management of chronic viral hepatitis: a Canadian consensus conference 2004.
Topics: Adenine; Adult; Antiviral Agents; Canada; Child; Child, Preschool; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Hepacivirus; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C Antibodies; Hepatitis C, Chronic; Humans; Infant, Newborn; Interferon-alpha; Lamivudine; Male; Organophosphonates; Polymerase Chain Reaction; Practice Guidelines as Topic; Pregnancy; RNA, Viral; Viral Hepatitis Vaccines | 2004 |
[Subjective literature review: adefovir-dipivoxil].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Hepatitis B, Chronic; Humans; Organophosphonates | 2004 |
Drug-induced renal failure in the ICU.
Topics: Acute Kidney Injury; Adenine; Amphotericin B; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Calcineurin Inhibitors; Cidofovir; Cyclooxygenase Inhibitors; Cytosine; Foscarnet; Hemodynamics; Humans; Hydroxyethyl Starch Derivatives; Immunoglobulins, Intravenous; Intensive Care Units; Kidney; Organophosphonates; Tacrolimus | 2004 |
Tenofovir disoproxil fumarate: a review of its use in the management of HIV infection.
Topics: Adenine; Area Under Curve; Biological Availability; Double-Blind Method; Drug Interactions; Half-Life; HIV Infections; Humans; Metabolic Clearance Rate; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir; Tissue Distribution | 2005 |
Care of patients with chronic hepatitis B and HIV co-infection: recommendations from an HIV-HBV International Panel.
Topics: Adenine; Antiviral Agents; Comorbidity; Deoxycytidine; Disease Progression; Drug Monitoring; Emtricitabine; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Tenofovir | 2005 |
Adverse effects of antiretroviral therapy for HIV infection: a review of selected topics.
Topics: Adenine; Alkynes; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cardiovascular Diseases; Cyclopropanes; Drug Monitoring; Drug Therapy, Combination; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Kidney Diseases; Lopinavir; Metabolic Syndrome; Nevirapine; Organophosphonates; Oxazines; Pyrimidinones; Risk Factors; Tenofovir | 2005 |
[Chronic hepatitis B: which patients should be treated and how?].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Patient Care Planning; Patient Selection; Polyethylene Glycols; Prognosis; Recombinant Proteins | 2005 |
[Management of chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Mutation; Organophosphonates; Patient Selection; Polyethylene Glycols; Recombinant Proteins; Recurrence; Time Factors; Virus Replication | 2005 |
Adefovir-lamivudine combination therapy and hepatitis B viral kinetics.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome; Virulence | 2005 |
Adefovir dipivoxil: focus on its use in the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Monitoring; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2005 |
[Clinical and virologic characteristics and treatment for chronic hepatitis B: relation with HBV genotypes].
Topics: Adenine; Antiviral Agents; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Prognosis | 2005 |
Drugs in development for hepatitis B.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Guanine; Hepatitis B; Humans; Interferon alpha-2; Interferon-alpha; Nucleosides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2005 |
Acute renal failure and Fanconi syndrome in an AIDS patient on tenofovir treatment--case report and review of literature.
Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adenine; Anti-HIV Agents; Creatinine; Fanconi Syndrome; Female; Humans; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2005 |
Fanconi syndrome associated with use of tenofovir in HIV-infected patients: a case report and review of the literature.
Topics: Adenine; Fanconi Syndrome; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Editorial comment: tenofovir nephrotoxicity--vigilance required.
Topics: Adenine; Fanconi Syndrome; Glycosuria; HIV Infections; Humans; Hypokalemia; Hypophosphatemia; Organophosphonates; Proteinuria; Renal Insufficiency; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Management of HIV-infected patients with multidrug-resistant virus.
Topics: Adenine; Anti-HIV Agents; Anti-Retroviral Agents; Atazanavir Sulfate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Enfuvirtide; HIV Envelope Protein gp41; HIV Infections; HIV-1; Humans; Oligopeptides; Organophosphonates; Peptide Fragments; Pyridines; Pyrones; Randomized Controlled Trials as Topic; Sulfonamides; Tenofovir; Treatment Failure; Viral Load | 2004 |
Tenofovir and didanosine: a dangerous liaison.
Topics: Adenine; Anti-HIV Agents; Didanosine; Drug Interactions; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Tenofovir | 2005 |
Clinical pharmacokinetics and summary of efficacy and tolerability of atazanavir.
Topics: Adenine; Age Factors; Alkynes; Atazanavir Sulfate; Benzoxazines; Clinical Trials as Topic; Cyclopropanes; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Liver; Oligopeptides; Organophosphonates; Oxazines; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Sex Factors; Tenofovir | 2005 |
Severe toxicity associated with the combination of tenofovir and didanosine: case report and review.
Topics: Acidosis, Lactic; Acute Disease; Adenine; Anti-HIV Agents; Didanosine; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Liver Failure; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
[The treatment of HIV infection].
Topics: Adenine; Anti-Retroviral Agents; Carbamates; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Therapy, Combination; Furans; HIV Infections; Humans; Lamivudine; Nevirapine; Organophosphates; Organophosphonates; Risk Factors; Sulfonamides; Tenofovir; Zidovudine | 2005 |
[Drug therapy in chronic liver disease].
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Antiviral Agents; Azathioprine; Cholangitis, Sclerosing; Chronic Disease; Drug Therapy, Combination; Fatty Liver; Hemochromatosis; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis, Autoimmune; Hepatolenticular Degeneration; Humans; Immunosuppression Therapy; Interferons; Lamivudine; Liver Cirrhosis, Biliary; Liver Diseases; Organophosphonates; Prednisolone; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ribavirin; Time Factors | 2005 |
Tenofovir-associated acute and chronic kidney disease: a case of multiple drug interactions.
Topics: Adenine; Aged; Anti-HIV Agents; Creatinine; Drug Interactions; Humans; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Risk Factors; Tenofovir | 2006 |
Understanding hepatitis B.
Topics: Acute Disease; Adenine; Algorithms; Antiviral Agents; Hepatitis B; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Recombinant Proteins | 2005 |
Therapeutic options for chronic hepatitis B: considerations and controversies.
Topics: Adenine; Antiviral Agents; Decision Making; DNA, Viral; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Practice Guidelines as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome | 2006 |
[New virologic tests and their application in management of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genetic Variation; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Phenotype; Research; Reverse Transcriptase Inhibitors; Viral Load; Virology; Virus Replication | 2006 |
[Treatment of chronic hepatitis B].
Topics: Adenine; Administration, Oral; Antiviral Agents; Biopsy; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Drug Tolerance; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Liver; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reverse Transcriptase Inhibitors; Time Factors; Virus Replication | 2006 |
[Liver transplantation for complications of hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Follow-Up Studies; Guanine; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Mutation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Vaccination; Viral Load; Virus Replication | 2006 |
HepDirect prodrugs for targeting nucleotide-based antiviral drugs to the liver.
Topics: Adenine; Animals; Antiviral Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Haplorhini; Hepatitis B; Humans; Liver; Nucleotides; Organophosphonates; Organophosphorus Compounds; Phosphotransferases; Prodrugs; Randomized Controlled Trials as Topic; Rats | 2006 |
Hepatitis B virus genotypes and response to antiviral therapy.
Topics: Adenine; Antiviral Agents; Genotype; Hepatitis B; Hepatitis B virus; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2006 |
Medical therapy of patients affected by HBeAg-negative chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2006 |
Use of tenofovir disoproxil fumarate and emtricitabine combination in HIV-infected patients.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Organophosphonates; Tenofovir | 2006 |
Personal view: the management of chronic hepatitis B infection.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Tenofovir | 2006 |
Prevention and treatment of recurrent Hepatitis B after liver transplantation: the current role of nucleoside and nucleotide analogues.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Nucleosides; Nucleotides; Organophosphonates; Recurrence; Tenofovir | 2006 |
Current treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Forecasting; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunologic Factors; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleocapsid; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reverse Transcriptase Inhibitors | 2006 |
Antiviral treatment for chronic hepatitis B virus infection--immune modulation or viral suppression?
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Fibrosis; Genotype; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Liver Neoplasms; Nucleosides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reverse Transcriptase Inhibitors | 2006 |
Perspectives on the development of acyclic nucleotide analogs as antiviral drugs.
Topics: Adenine; Animals; Antiviral Agents; Dogs; Drug Design; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Nucleotides; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir | 2006 |
Tenofovir disoproxil fumarate for the treatment of HIV infection.
Topics: Adenine; Animals; Drug Administration Schedule; Drug Interactions; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; HIV Infections; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
An update and review of antiretroviral therapy.
Topics: Adenine; Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Carbamates; Clinical Trials as Topic; Deoxycytidine; Dideoxynucleosides; Drug Administration Schedule; Drug Combinations; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Drugs, Investigational; Emtricitabine; Enfuvirtide; Furans; HIV Envelope Protein gp41; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Oligopeptides; Organophosphates; Organophosphonates; Patient Compliance; Peptide Fragments; Pyridines; Pyrones; Reverse Transcriptase Inhibitors; Sulfonamides; Tenofovir | 2006 |
Tenofovir disoproxil fumarate: role in hepatitis B treatment.
Topics: Adenine; DNA, Viral; Hepatitis B; Hepatitis B virus; Humans; Organophosphonates; Tenofovir; Treatment Outcome | 2006 |
Hepatitis B: the pathway to recovery through treatment.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis C, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors | 2006 |
Adefovir dipivoxil and pegylated interferon alfa-2a for the treatment of chronic hepatitis B: a systematic review and economic evaluation.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Drug Carriers; Drug Therapy, Combination; Health Services; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Organophosphonates; Patient Selection; Polyethylene Glycols; Quality of Life; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Recombinant Proteins | 2006 |
New developments in the treatment of chronic hepatitis B.
Topics: Adenine; Animals; Antiviral Agents; Clinical Trials as Topic; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Patient Selection; Polyethylene Glycols; Recombinant Proteins | 2006 |
Chronic Hepatitis B and C--current treatment and future therapeutic prospects.
Topics: Adenine; Antiviral Agents; DNA-Directed RNA Polymerases; Hepatitis B e Antigens; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Protease Inhibitors; Recombinant Proteins; Ribavirin | 2006 |
Antiretroviral therapy for hepatitis B virus-HIV-coinfected patients: promises and pitfalls.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Guanine; Hepatitis B; Hepatitis B virus; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Preventive Medicine; Tenofovir | 2006 |
[Therapy of hepatitis B].
Topics: Adenine; Administration, Oral; Antiviral Agents; Diagnosis, Differential; Hepatitis B, Chronic; Humans; Immunologic Factors; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome | 2006 |
[Therapy of hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Drug Antagonism; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Forecasting; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Organophosphonates; Polyethylene Glycols; Prognosis; Recombinant Proteins; Reverse Transcriptase Inhibitors; Time Factors | 2006 |
Tenofovir disoproxil fumarate-emtricitabine coformulation for once-daily dual NRTI backbone.
Topics: Adenine; Animals; Chemistry, Pharmaceutical; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Emtricitabine; HIV Infections; HIV Reverse Transcriptase; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
[Advances in the study of nucleoside antiviral drugs].
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Arabinofuranosyluracil; Cidofovir; Cytosine; Dioxolanes; Humans; Molecular Structure; Nucleosides; Organophosphonates; Purine Nucleosides; Tenofovir | 2006 |
Evolving simplified treatment strategies for HIV infection: the role of a single-class quadruple-nucleoside/nucleotide regimen of trizivir and tenofovir.
Topics: Adenine; Anti-HIV Agents; Dideoxynucleosides; Drug Combinations; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2006 |
Tenofovir plus didanosine as Nrti backbone in HIV-infected subjects.
Topics: Adenine; Anti-HIV Agents; Didanosine; Drug Antagonism; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tenofovir | 2006 |
[Managing resistance to analogue antiviral drugs in a decompensated cirrhosis patient].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Mutation; Organophosphonates; Practice Guidelines as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome | 2006 |
[Treating chronic lamivudine-resistant hepatitis B in HIV co-infected patients].
Topics: Adenine; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2006 |
[Managing lamivudine resistance in liver transplantation for hepatitis B liver disease].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Practice Guidelines as Topic; Reverse Transcriptase Inhibitors; Secondary Prevention; Treatment Outcome | 2006 |
[Impact of resistance to analogue antivirals and therapeutic strategies in situations of dialysis, kidney transplantation, vasculitis, and preemptive treatments in immunosuppressed patients].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Vaccines; Humans; Immunocompromised Host; Kidney Failure, Chronic; Kidney Transplantation; Lamivudine; Organophosphonates; Renal Dialysis; Reverse Transcriptase Inhibitors; Treatment Outcome; Vasculitis | 2006 |
Why adefovir is not yet available in Canada.
Topics: Adenine; Antiviral Agents; Canada; Drug Utilization; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Organophosphonates | 2006 |
[Renal toxicity in HIV-infected patients receiving HAART including tenofovir].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Interactions; HIV Infections; Humans; Kidney Diseases; Organophosphonates; Tenofovir | 2006 |
Cross-study analysis of the relative efficacies of oral antiviral therapies for chronic hepatitis B infection in nucleoside-naive patients.
Topics: Adenine; Administration, Oral; Algorithms; Antiviral Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Randomized Controlled Trials as Topic; Treatment Outcome | 2007 |
[Resistance to adefovir in patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; Treatment Outcome | 2006 |
A systematic review and economic evaluation of adefovir dipivoxil and pegylated interferon-alpha-2a for the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; England; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Proteins; Wales | 2007 |
Efavirenz/emtricitabine/tenofovir disoproxil fumarate fixed-dose combination: first-line therapy for all?
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; HIV-1; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Renal safety of tenofovir disoproxil fumarate.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; HIV Infections; Humans; Kidney; Kidney Diseases; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Improving outcomes for patients with chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2007 |
Hepatitis B reverse seroconversion in HIV-positive patients: case series and review of the literature.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; CD4 Lymphocyte Count; DNA, Viral; Hepatitis B; Hepatitis B Surface Antigens; HIV Seropositivity; Humans; Lamivudine; Middle Aged; Organophosphonates; Tenofovir | 2007 |
[Drugs for hepatitis B and C infection].
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Lamivudine; Mutation; Oligopeptides; Organophosphonates; Proline; Ribavirin; Serine Proteinase Inhibitors | 2007 |
[Mechanisms of drug resistance in hepatitis viruses B and C].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Gene Products, pol; Guanine; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Interferons; Lamivudine; Mutation; Organophosphonates; Ribavirin; Viral Nonstructural Proteins | 2007 |
[Advances in research of hepatitis B virus resistance to adefovir].
Topics: Adenine; Drug Resistance, Viral; Hepatitis B virus; Humans; Organophosphonates | 2007 |
Treatment paradigms on hepatitis B e antigen-negative chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine | 2007 |
Drug resistance in antiviral treatment for infections with hepatitis B and C viruses.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Lamivudine; Organophosphonates | 2007 |
Treatment of chronic hepatitis B in HIV-infected patients in 2007.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2007 |
Chronic hepatitis B with advanced fibrosis or cirrhosis: impact of antiviral therapy.
Topics: Adenine; Antiviral Agents; Disease Progression; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Organophosphonates | 2007 |
Pre-exposure prophylaxis for HIV infection: what if it works?
Topics: Adenine; Anti-HIV Agents; Attitude of Health Personnel; Drug Administration Schedule; Female; HIV Infections; HIV Seropositivity; Humans; Male; Organophosphonates; Public Health; Risk-Taking; Tenofovir | 2007 |
Quadruple nucleoside therapy with zidovudine, lamivudine, abacavir and tenofovir in the treatment of HIV.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV Infections; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Practice Guidelines as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load; Zidovudine | 2007 |
Comparative cost-effectiveness of antiviral therapies in patients with chronic hepatitis B: a systematic review of economic evidence.
Topics: Adenine; Antiviral Agents; China; Cost-Benefit Analysis; Databases, Factual; Hepatitis B, Chronic; Humans; Organophosphonates; United States | 2007 |
The first once-daily single-tablet regimen for the treatment of HIV-infected patients.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; HIV-1; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tablets; Tenofovir; Therapeutic Equivalency | 2007 |
HIV-1 infection and the kidney: an evolving challenge in HIV medicine.
Topics: Acute Disease; Acute Kidney Injury; Adenine; AIDS-Associated Nephropathy; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Black or African American; Chronic Disease; Comorbidity; Disease Progression; HIV Infections; HIV-1; Humans; Kidney; Kidney Diseases; Kidney Failure, Chronic; Kidney Transplantation; Mice; Mice, Transgenic; Microcirculation; Organophosphonates; Tenofovir; Viral Proteins | 2007 |
Tenofovir gel--the new HIV prevention 'banker'?
Topics: Adenine; Anti-HIV Agents; Clinical Trials, Phase II as Topic; Drug Approval; Female; HIV Infections; Humans; Organophosphonates; Tenofovir; Vaginal Creams, Foams, and Jellies | 2007 |
[Indications for antiviral therapy for chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Biomarkers; Carrier State; Consensus Development Conferences as Topic; DNA, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Japan; Lamivudine; Organophosphonates; Societies, Medical | 2007 |
[Therapy for chronic hepatitis B: relationship between HBV genotype and efficacy or resistance of anti-viral therapy].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2007 |
[Attention-getting sexually transmitted diseases: Hepatitis B].
Topics: Adenine; Adenosine; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Genotype; Guanine; Guanosine; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Sexually Transmitted Diseases, Viral | 2007 |
Treatment options for lipodystrophy in HIV-positive patients.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Health Behavior; HIV-Associated Lipodystrophy Syndrome; Humans; Lipid Metabolism; Organophosphonates; Tenofovir | 2008 |
Review article: Success and failure of nucleoside and nucleotide analogues in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Virus Replication | 2007 |
Kidney biopsy in HIV: beyond HIV-associated nephropathy.
Topics: Acute Disease; Adenine; AIDS-Associated Nephropathy; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biopsy; Comorbidity; Diabetic Nephropathies; Diagnosis, Differential; Female; HIV Infections; Humans; Hypertension; Immune Complex Diseases; Kidney; Kidney Diseases; Kidney Glomerulus; Middle Aged; Nephritis, Interstitial; Organophosphonates; Risk Assessment; Risk Factors; Tenofovir | 2008 |
[Pharmacological agents for the treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine; Time Factors; Treatment Outcome | 2008 |
Evaluating anti-viral drug selection and treatment duration in HBeAg-negative chronic hepatitis B: a cost-effectiveness analysis.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Epidemiologic Methods; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2008 |
Resistance testing methodologies and mechanisms of resistance.
Topics: Adenine; Anti-HIV Agents; CCR5 Receptor Antagonists; Drug Resistance, Viral; HIV; Humans; Lopinavir; Nitriles; Organophosphonates; Pyridazines; Pyrimidines; Pyrimidinones; Tenofovir | 2007 |
Clinical implications of resistance patterns against HBV-polymerase inhibitors for the treatment of chronic hepatitis B.
Topics: Adenine; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2007 |
Experience with tenofovir disoproxil fumarate for antiretroviral therapy.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Retroviral Agents; Child; Drug Interactions; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir; Treatment Outcome | 2008 |
The discovery of antiviral agents: ten different compounds, ten different stories.
Topics: Acyclovir; Adenine; Antiviral Agents; Benzodiazepines; Benzylamines; Cidofovir; Cyclams; Cytosine; Heterocyclic Compounds; Humans; Imidazoles; Nucleosides; Organophosphonates; Tenofovir; Valacyclovir; Valine; Virus Diseases | 2008 |
Review article: current antiviral therapy of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2008 |
[The ABC of viral hepatitis].
Topics: Adenine; Antiviral Agents; Hepatitis A; Hepatitis B; Hepatitis C; Hepatitis, Viral, Human; Humans; Interferon-alpha; Organophosphonates; Vaccination | 2008 |
[Treatment recommendations of chronic hepatitis B. Did the world escape us?].
Topics: Adenine; Antiviral Agents; Disease Management; Drug Therapy, Combination; Guanine; Health Planning Guidelines; Health Services Accessibility; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; National Health Programs; Organophosphonates; Poland; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Proteins; Treatment Outcome | 2008 |
[AIDS: ethics and scientific investigation on human beings].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Anti-HIV Agents; Azathioprine; Clinical Trials as Topic; Congresses as Topic; Cyclosporine; Developing Countries; Ditiocarb; Double-Blind Method; Drug Evaluation, Preclinical; Drug Therapy, Combination; Ethics Committees, Research; Human Experimentation; Humans; Informed Consent; Mass Media; Oligodeoxyribonucleotides, Antisense; Organophosphonates; Practice Guidelines as Topic; Stavudine; Tenofovir; Thionucleotides | 2008 |
Treatment of chronic hepatitis B infection: an update of Swedish recommendations.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B, Chronic; HIV Infections; Humans; Immunocompromised Host; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Transplantation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Sweden; Tenofovir | 2008 |
[Management of chronic hepatitis B in treatment-naive patients].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Korea; Lamivudine; Organophosphonates; Polyethylene Glycols; Practice Guidelines as Topic; Recombinant Proteins | 2008 |
[Management of antiviral-resistant chronic hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Multiple, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pyrimidinones; Telbivudine; Thymidine; Treatment Outcome | 2008 |
[Combination therapy in chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2008 |
[Is it possible to stop nucleos(t)ide analogue based therapy in chronic hepatitis B?].
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Recurrence | 2008 |
Tenofovir: what have over 1 million years of patient experience taught us?
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Drug Resistance, Viral; HIV Infections; Humans; Organophosphonates; Tenofovir | 2008 |
A review of telbivudine for the management of chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Resistance, Viral; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine | 2008 |
LB80380: a promising new drug for the treatment of chronic hepatitis B.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunologic Factors; Organophosphonates; Practice Guidelines as Topic | 2008 |
Hepatitis B and liver transplantation: 2008 update.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B Vaccines; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2009 |
A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: 2008 update.
Topics: Adenine; Antiviral Agents; Case Management; DNA, Viral; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir; Treatment Outcome; United States | 2008 |
Kidney disease in patients with HIV infection and AIDS.
Topics: Adenine; HIV Infections; Humans; Kidney Diseases; Organophosphonates; Risk Factors; Tenofovir | 2008 |
[Acyclic nucleoside phosphonates as potential antineoplastic agents].
Topics: Adenine; Alanine; Animals; Antineoplastic Agents; Cell Line, Tumor; Guanine; Humans; Lymphoma, Non-Hodgkin; Nucleosides; Organophosphonates; Organophosphorus Compounds; Purines | 2008 |
Progress in the discovery of compounds inhibiting orthopoxviruses in animal models.
Topics: Adenine; Animals; Antiviral Agents; Benzamides; Cidofovir; Cytosine; Disease Models, Animal; Drug Discovery; Humans; Isoindoles; Organophosphonates; Orthopoxvirus; Prodrugs | 2008 |
[Interferon in hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Therapy, Combination; Genotype; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Multicenter Studies as Topic; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Randomized Controlled Trials as Topic; Recombinant Proteins; Telbivudine; Thymidine; Treatment Outcome | 2008 |
[Nucleoside and nucleotide analogs in the treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Multicenter Studies as Topic; Nucleosides; Organophosphonates; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2008 |
[Entecavir].
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Multicenter Studies as Topic; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load; Virus Replication | 2008 |
[Resistance in hepatitis B virus].
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Gene Products, pol; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Models, Molecular; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Virus Replication | 2008 |
[Clinical management of patients with chronic hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Biopsy; Combined Modality Therapy; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Genotype; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver; Liver Transplantation; Male; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2008 |
[Hepatitis B in patients with HIV infection].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Comorbidity; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B; Hepatitis B Vaccines; Hepatitis B virus; HIV; HIV Infections; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2008 |
Pharmacologic aspects of new antiretroviral drugs.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Darunavir; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Nitriles; Organophosphonates; Oxazines; Practice Guidelines as Topic; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Sulfonamides | 2009 |
Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Risk; Tenofovir | 2009 |
Role of combination therapy in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Salvage Therapy; Treatment Outcome | 2009 |
Tenofovir-associated nephrotoxicity in two HIV-infected adolescent males.
Topics: Adenine; Adolescent; Age Factors; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Black or African American; Blood Urea Nitrogen; CD4 Lymphocyte Count; Creatinine; Diagnosis, Differential; HIV Infections; Humans; Hypophosphatemia; Infectious Disease Transmission, Vertical; Male; Organophosphonates; Renal Insufficiency; Reverse Transcriptase Inhibitors; Rickets; Risk Factors; Safety; Tenofovir | 2009 |
Nucleos(t)ide analogues for hepatitis B virus: strategies for long-term success.
Topics: Adenine; Adenine Nucleotides; Alanine Transaminase; Carcinoma, Hepatocellular; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine; Treatment Outcome; Virus Replication | 2008 |
Peginterferon for the treatment of chronic hepatitis B in the era of nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Practice Guidelines as Topic; Pyrimidinones; Randomized Controlled Trials as Topic; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2008 |
[Tenofovir: pharmacology and interactions].
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Biological Availability; Biotransformation; Child; Child, Preschool; Deoxyadenine Nucleotides; DNA, Viral; Drug Interactions; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Diseases; Liver Diseases; Middle Aged; Molecular Structure; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication; Young Adult | 2008 |
[Clinical data I. Clinical experience with tenofovir in combination with nonnucleoside analogue transcriptase inhibitors].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Clinical Trials, Phase III as Topic; Double-Blind Method; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; HIV Reverse Transcriptase; Humans; Multicenter Studies as Topic; Organophosphonates; Patient Acceptance of Health Care; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2008 |
[Clinical data II. Clinical experience of tenofovir DF in combination with protease inhibitors].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Clinical Trials as Topic; Cohort Studies; Deoxycytidine; Diabetic Nephropathies; Double-Blind Method; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Emtricitabine; HIV; HIV Infections; HIV Protease Inhibitors; HIV Reverse Transcriptase; Humans; Kidney Diseases; Multicenter Studies as Topic; Organophosphonates; Randomized Controlled Trials as Topic; Retrospective Studies; Reverse Transcriptase Inhibitors; Salvage Therapy; Tenofovir; Treatment Outcome | 2008 |
[Tenofovir as a strategy to avoid or limit adverse effects].
Topics: Adenine; Anemia; Anti-HIV Agents; Antimetabolites; Clinical Trials as Topic; DNA, Mitochondrial; Double-Blind Method; Drug Therapy, Combination; Dyslipidemias; Glucose Metabolism Disorders; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Multicenter Studies as Topic; Organophosphonates; Prospective Studies; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zidovudine | 2008 |
[Tenofovir DF in rescue regimens].
Topics: Adenine; Anti-HIV Agents; Antimetabolites; Clinical Trials, Phase III as Topic; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; HIV; HIV Infections; HIV Reverse Transcriptase; Humans; Multicenter Studies as Topic; Mutation; Organophosphonates; Randomized Controlled Trials as Topic; Retrospective Studies; Reverse Transcriptase Inhibitors; Salvage Therapy; Selection, Genetic; Tenofovir; Thymidine; Treatment Failure; Viral Load; Zalcitabine | 2008 |
[Role of tenofovir in HIV and hepatitis C virus coinfection].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Chemical and Drug Induced Liver Injury; Disease Progression; Drug Hypersensitivity; Drug Interactions; Drug Therapy, Combination; Fatty Liver; Glucose Metabolism Disorders; Hepatitis C, Chronic; HIV Infections; Humans; Interferons; Liver; Liver Cirrhosis; Organophosphonates; Reverse Transcriptase Inhibitors; Ribavirin; Tenofovir | 2008 |
[Are all analogue combinations equal?].
Topics: Adenine; Anti-HIV Agents; Antimetabolites; Antiretroviral Therapy, Highly Active; Cardiovascular Diseases; Clinical Trials as Topic; Cohort Studies; Drug Interactions; Drug Therapy, Combination; Dyslipidemias; Gastrointestinal Diseases; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine | 2008 |
[Management of renal toxicity in HIV-positive patients. What to measure, how to measure it and how frequently].
Topics: Adenine; Algorithms; Anti-HIV Agents; beta 2-Microglobulin; Clinical Trials as Topic; Cohort Studies; Creatinine; Drug Monitoring; Female; HIV Infections; Humans; Hypophosphatemia; Incidence; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Male; Organophosphonates; Proteinuria; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors | 2008 |
HBeAg-negative chronic hepatitis B: why do I treat my patients with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2009 |
Hepatitis B therapy in children.
Topics: Adenine; Adolescent; Antiviral Agents; Child; Child, Preschool; Drug Therapy, Combination; Hepatitis B; Humans; Infant; Infant, Newborn; Interferon-alpha; Lamivudine; Organophosphonates; Treatment Outcome | 2009 |
Chronic hepatitis B: early viral suppression and long-term outcomes of therapy with oral nucleos(t)ides.
Topics: Adenine; Administration, Oral; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine; Time Factors; Treatment Outcome | 2009 |
On-treatment outcome prediction and adjustment during chronic hepatitis B therapy: now and future.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; DNA, Viral; Drug Resistance, Multiple, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Medication Adherence; Nucleosides; Organophosphonates; Polyethylene Glycols; Prognosis; Pyrimidinones; Recombinant Proteins; Telbivudine; Thymidine; Time Factors; Treatment Outcome | 2009 |
[Current role of tenofovir in clinical medicine].
Topics: Adenine; Anti-HIV Agents; Antimetabolites; Antiretroviral Therapy, Highly Active; Chemical and Drug Induced Liver Injury; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Dyslipidemias; Glucose Metabolism Disorders; Hepatitis, Viral, Human; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Liver Diseases; Meta-Analysis as Topic; Organophosphonates; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Retrospective Studies; Reverse Transcriptase Inhibitors; Salvage Therapy; Tenofovir; Thymidine; Viral Load | 2008 |
Post-liver transplant hepatitis B prophylaxis: the role of oral nucleos(t)ide analogues.
Topics: Adenine; Administration, Oral; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Graft Survival; Guanine; Hepatitis B; Humans; Immunoglobulins; Injections, Intramuscular; Lamivudine; Liver Transplantation; Nucleosides; Nucleotides; Organophosphonates; Secondary Prevention; Tenofovir; Treatment Outcome | 2009 |
[Chronic hepatitis B: current therapy].
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Disease Progression; Guanine; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Humans; Immunotherapy, Active; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir; Treatment Outcome | 2008 |
Tenofovir disoproxil fumarate in pregnancy and prevention of mother-to-child transmission of HIV-1: is it time to move on from zidovudine?
Topics: Adenine; Adult; Africa South of the Sahara; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Diseases; Child; Child, Preschool; Congenital Abnormalities; Disease Models, Animal; Drug Resistance, Viral; Female; Health Services Accessibility; HIV Infections; HIV-1; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Macaca; Mitochondria; Nevirapine; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir; Zidovudine | 2009 |
The option of liver transplantation for hepatitis B: where are we?
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Postoperative Complications; Practice Guidelines as Topic; Secondary Prevention; Viral Load | 2009 |
Liver transplantation for hepatitis B virus. Pre-emptive and peri-operative prophylaxis.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Perioperative Care; Postoperative Complications; Secondary Prevention; Treatment Outcome | 2009 |
Adefovir dipivoxil and pegylated interferon alpha for the treatment of chronic hepatitis B: an updated systematic review and economic evaluation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Female; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates | 2009 |
The CASTLE study: atazanavir/r versus lopinavir/r in antiretroviral-naive patients.
Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; Clinical Trials, Phase III as Topic; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Lopinavir; Multicenter Studies as Topic; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Randomized Controlled Trials as Topic; Ritonavir; Tenofovir; Treatment Outcome | 2009 |
Effects of nucleoside reverse transcriptase inhibitor backbone on the efficacy of first-line boosted highly active antiretroviral therapy based on protease inhibitors: meta-regression analysis of 12 clinical trials in 5168 patients.
Topics: Adenine; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Intention to Treat Analysis; Lamivudine; Male; Organophosphonates; Randomized Controlled Trials as Topic; Regression Analysis; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2009 |
Tenofovir for the treatment of hepatitis B virus.
Topics: Adenine; Antiviral Agents; Drug Approval; Drug Interactions; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir; United States; United States Food and Drug Administration | 2009 |
Meta-analysis: adefovir dipivoxil in combination with lamivudine in patients with lamivudine-resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Treatment Outcome | 2009 |
Pharmacogenetics of tenofovir treatment.
Topics: Adenine; Anti-HIV Agents; Anti-Retroviral Agents; HIV Infections; HIV-1; Humans; Kidney Diseases; Kidney Tubules; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organophosphonates; Pharmacogenetics; Polymorphism, Genetic; Tenofovir | 2009 |
Tenofovir disoproxil fumarate: in chronic hepatitis B.
Topics: Adenine; Administration, Oral; Adult; Hepatitis B, Chronic; Humans; Organophosphonates; Prodrugs; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Prevention of recurrent hepatitis B virus infection after liver transplantation: hepatitis B immunoglobulin, antiviral drugs, or both? Systematic review and meta-analysis.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; Controlled Clinical Trials as Topic; Drug Therapy, Combination; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Middle Aged; Organophosphonates; Randomized Controlled Trials as Topic; Secondary Prevention; Treatment Outcome | 2010 |
Antiretroviral medications: adverse effects on the kidney.
Topics: Adenine; AIDS-Associated Nephropathy; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Humans; Indinavir; Kidney; Organophosphonates; Tenofovir | 2010 |
Lenalidomide-induced acute liver failure.
Topics: Adenine; Aged, 80 and over; Antineoplastic Agents; Antiviral Agents; Hepatitis B, Chronic; Humans; Lenalidomide; Liver Failure, Acute; Male; Myelodysplastic Syndromes; Organophosphonates; Thalidomide | 2009 |
Current treatments for patients with HBeAg-positive chronic hepatitis B virus infection: a comparison focusing on HBeAg seroconversion.
Topics: Adenine; Adjuvants, Immunologic; Antiviral Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Randomized Controlled Trials as Topic; Risk Assessment; Serologic Tests; Severity of Illness Index; Tenofovir; Treatment Outcome | 2010 |
Avoiding and managing lamivudine resistance in chronic hepatitis B: current approaches and potential strategies including pegylated interferon.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2010 |
Effect of newer oral antiviral agents on future therapy of chronic hepatitis B.
Topics: Adenine; Administration, Oral; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2010 |
[Hepatitis B reactivation in an HbsAg-negative/anti-HBc-positive patient with B-cell non-Hodgkin lymphoma receiving chemotherapy with rituximab].
Topics: Adenine; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antibody Specificity; Antineoplastic Combined Chemotherapy Protocols; Comorbidity; Cyclophosphamide; Fatal Outcome; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunologic Factors; Immunotherapy; Liver Failure; Lymphoma, B-Cell, Marginal Zone; Male; Organophosphonates; Prednisone; Recurrence; Rituximab; Tenofovir; Vincristine; Virus Activation | 2010 |
Renal toxicity associated with tenofovir use.
Topics: Adenine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Kidney; Kidney Diseases; Male; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
Current therapeutic strategies for recurrent hepatitis B virus infection after liver transplantation.
Topics: Adenine; Antiviral Agents; Asia; Guanine; Hepatitis B; Hepatitis B virus; Humans; Interferons; Lamivudine; Liver Transplantation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
Tenofovir disoproxil fumarate for the treatment of chronic hepatitis B infection.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Cost-Benefit Analysis; Disease Progression; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Models, Economic; Organophosphonates; Quality of Life; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; United Kingdom | 2010 |
Economic evaluation of ART in resource-limited countries.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cost-Benefit Analysis; Developing Countries; Drug Monitoring; Health Care Costs; HIV Infections; Humans; Organophosphonates; RNA, Viral; Stavudine; Tenofovir; Viral Load | 2010 |
On-treatment monitoring of chronic hepatitis B virus infection: an Asian-Pacific perspective.
Topics: Adenine; Antiviral Agents; Asia; Biomarkers; DNA, Viral; Drug Monitoring; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2010 |
Tenofovir and entecavir are the most effective antiviral agents for chronic hepatitis B: a systematic review and Bayesian meta-analyses.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Tenofovir | 2010 |
Lamivudine or adefovir dipivoxil alone or combined with immunoglobulin for preventing hepatitis B recurrence after liver transplantation.
Topics: Adenine; Antiviral Agents; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Randomized Controlled Trials as Topic; Secondary Prevention | 2010 |
Systematic review and meta-analysis: renal safety of tenofovir disoproxil fumarate in HIV-infected patients.
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Kidney Diseases; Organophosphonates; Tenofovir | 2010 |
Mixed treatment comparison meta-analysis evaluating the relative efficacy of nucleos(t)ides for treatment of nucleos(t)ide-naive patients with chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load | 2010 |
The risk of HIV drug resistance following implementation of pre-exposure prophylaxis.
Topics: Adenine; Animals; Anti-HIV Agents; Deoxycytidine; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV; HIV Infections; Humans; Organophosphonates; Risk Assessment; Tenofovir; Viremia | 2010 |
Systemic preexposure prophylaxis for human immunodeficiency virus infection.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Deoxycytidine; Emtricitabine; Female; HIV; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Occupational Exposure; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Risk Factors; Risk-Taking; Tenofovir | 2010 |
Tenofovir or zidovudine in three-drug combination therapy with one nucleoside reverse transcriptase inhibitor and one non-nucleoside reverse transcriptase inhibitor for initial treatment of HIV infection in antiretroviral-naïve individuals.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Child; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Lamivudine; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2010 |
Tenofovir disoproxil fumarate in the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase III as Topic; Double-Blind Method; Hepatitis B virus; Hepatitis B, Chronic; Humans; Multicenter Studies as Topic; Organophosphonates; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2010 |
Efavirenz/emtricitabine/tenofovir disoproxil fumarate single-tablet regimen (Atripla®): a review of its use in the management of HIV infection.
Topics: Adenine; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Medication Adherence; Organophosphonates; Oxazines; Patient Satisfaction; Quality of Life; Reverse Transcriptase Inhibitors | 2010 |
Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection.
Topics: Adenine; Chemoprevention; Deoxycytidine; Drug Interactions; Emtricitabine; Female; Food-Drug Interactions; HIV Infections; Humans; Male; Organophosphonates; Tenofovir | 2011 |
Inflammatory bowel disease and hepatitis B and C in Western Balkans: a referral centre study and review of the literature.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Combination; Female; Greece; Hepatitis B; Hepatitis C; Humans; Inflammatory Bowel Diseases; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Prevalence; Retrospective Studies; Ribavirin; Tenofovir; Treatment Outcome | 2010 |
[What's new in dermatological treatments?].
Topics: Adenine; Anti-HIV Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Clinical Trials as Topic; Cyclosporine; Dermatofibrosarcoma; Dermatologic Agents; Dermatology; Drug Therapy, Combination; Etanercept; Follow-Up Studies; Gels; HIV Infections; Humans; Imatinib Mesylate; Immunoglobulin G; Immunosuppressive Agents; Ipilimumab; Melanoma; Neoplasm Staging; Organophosphonates; Piperazines; Psoriasis; Pyrimidines; Receptors, Tumor Necrosis Factor; Skin Diseases; Skin Neoplasms; Survival Analysis; Tenofovir; Treatment Outcome; Ustekinumab | 2010 |
Review article: chronic hepatitis B - anti-viral or immunomodulatory therapy?
Topics: Adenine; Antiviral Agents; Decision Making; Guanine; Hepatitis B, Chronic; Humans; Immunomodulation; Interferon alpha-2; Interferon-alpha; Nucleosides; Organophosphonates; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Proteins; Tenofovir; Treatment Outcome | 2011 |
Systematic review of the literature on comparative effectiveness of antiviral treatments for chronic hepatitis B infection.
Topics: Adenine; Animals; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Recombinant Proteins; Treatment Outcome | 2011 |
Chronic hepatitis B: peginterferon or nucleos(t)ide analogues?
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir; Treatment Outcome | 2011 |
Treatment of HBeAg-positive chronic hepatitis B with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2011 |
Hepatitis B virus resistance to antiviral drugs: where are we going?
Topics: Adenine; Antiviral Agents; Capsid; Clinical Protocols; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Virus Internalization; Virus Replication | 2011 |
The impact of human immunodeficiency virus on viral hepatitis.
Topics: Adenine; Antiviral Agents; Deoxycytidine; Disease Progression; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B; Hepatitis C; Hepatitis Viruses; HIV Infections; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2011 |
Renal disease associated with antiretroviral therapy in the treatment of HIV.
Topics: Adenine; Anti-Retroviral Agents; Atazanavir Sulfate; HIV Infections; Humans; Indinavir; Kidney Diseases; Oligopeptides; Organophosphonates; Pyridines; Tenofovir | 2011 |
From old to new nucleoside reverse transcriptase inhibitors: changes in body fat composition, metabolic parameters and mitochondrial toxicity after the switch from thymidine analogs to tenofovir or abacavir.
Topics: Adenine; Adipose Tissue; Body Composition; Dideoxynucleosides; Drug Substitution; Humans; Metabolism; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zidovudine | 2011 |
Treatment of chronic hepatitis B: update of the recommendations from the 2007 Italian Workshop.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Italy; Liver Cirrhosis; Liver Neoplasms; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
Oral preexposure anti-HIV prophylaxis for high-risk U.S. populations: current considerations in light of new findings.
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Chemoprevention; Clinical Trials as Topic; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Risk; Tenofovir; United States | 2011 |
[Treatment of patients with lamivudine-resistant chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2011 |
Comparison of the 48-week efficacy between entecavir and adefovir in HBeAg-positive nucleos(t)ide-naïve Asian patients with chronic hepatitis B: a meta-analysis.
Topics: Adenine; Antiviral Agents; Asia; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Organophosphonates; Randomized Controlled Trials as Topic | 2011 |
Update on microbicide research and development - seeking new HIV prevention tools for women.
Topics: Adenine; Administration, Intravaginal; Adult; Africa South of the Sahara; Anti-HIV Agents; Anti-Infective Agents; Clinical Trials as Topic; Cyclohexanes; Drug Discovery; Female; HIV Infections; Humans; Male; Maraviroc; Organophosphonates; Pyridines; Pyrimidines; Tenofovir; Triazoles; Urea | 2011 |
Comparison of the efficacy of tenofovir and adefovir in the treatment of chronic hepatitis B: a systematic review.
Topics: Adenine; Antiviral Agents; Controlled Clinical Trials as Topic; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Treatment Outcome | 2011 |
Tenofovir-associated kidney toxicity in HIV-infected patients: a review of the evidence.
Topics: Adenine; Animals; Fanconi Syndrome; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Kidney Tubules, Proximal; Organophosphonates; Risk Factors; Tenofovir | 2011 |
The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond.
Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cidofovir; Cytosine; Guanosine; Hepatitis B; HIV Infections; Humans; Organophosphonates; Prodrugs; Structure-Activity Relationship; Tenofovir | 2011 |
Novel nephrotoxins.
Topics: Adenine; Alcohols; Angiogenesis Inhibitors; Anticonvulsants; Antipsychotic Agents; Dasatinib; Diphosphonates; Glutamates; Guanine; HIV Protease Inhibitors; Humans; Indoles; Kidney Diseases; Organophosphonates; Oxalates; Pamidronate; Pemetrexed; Phenindione; Plants, Toxic; Proton Pump Inhibitors; Pyrimidines; Pyrroles; Selective Serotonin Reuptake Inhibitors; Sunitinib; Tenofovir; Thiazoles; Triazines | 2011 |
[Interferon-based versus direct antiviral therapy in patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2011 |
[Progress and perspectives in treatment of chronic hepatitis B].
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2011 |
Amonafide: a potential role in treating acute myeloid leukemia.
Topics: Adenine; Animals; Antineoplastic Agents; Clinical Trials as Topic; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Survival Rate; Treatment Outcome | 2011 |
Hepatitis B immunoglobulin and/or nucleos(t)ide analogues for prophylaxis against hepatitis b virus recurrence after liver transplantation: a systematic review.
Topics: Adenine; Antiviral Agents; Chi-Square Distribution; Drug Therapy, Combination; Evidence-Based Medicine; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Organophosphonates; Risk Assessment; Risk Factors; Secondary Prevention; Time Factors; Treatment Outcome | 2011 |
Endocrine complications of human immunodeficiency virus infection: hypogonadism, bone disease and tenofovir-related toxicity.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Diseases; Endocrine System Diseases; HIV; HIV Infections; Humans; Hypogonadism; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
HIV prevention in southern Africa: why we must reassess our strategies?
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adolescent; Adult; Anti-HIV Agents; Circumcision, Male; Condoms; Condoms, Female; Female; HIV Infections; HIV Seropositivity; Humans; Interdisciplinary Communication; Male; Middle Aged; Organophosphonates; Preventive Medicine; Risk Reduction Behavior; Tenofovir; Young Adult | 2011 |
Drug safety evaluation of adefovir in HBV infection.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase III as Topic; Hepatitis B, Chronic; Humans; Organophosphonates; Randomized Controlled Trials as Topic | 2011 |
Antiviral therapy for hepatitis B infection during pregnancy and breastfeeding.
Topics: Adenine; Antiviral Agents; Breast Feeding; Female; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Placenta; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2011 |
Lamivudine plus adefovir combination therapy versus entecavir monotherapy for lamivudine-resistant chronic hepatitis B: a systematic review and meta-analysis.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Organophosphonates; Salvage Therapy; Time Factors; Treatment Outcome; Viral Load | 2011 |
Application of kinase bypass strategies to nucleoside antivirals.
Topics: Adenine; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytosine; History, 20th Century; History, 21st Century; Humans; Nucleosides; Nucleotides; Organophosphonates; Phosphotransferases; Tenofovir | 2011 |
Antiviral drugs for viruses other than human immunodeficiency virus.
Topics: Acyclovir; Adenine; Amantadine; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Foscarnet; Ganciclovir; Guanine; Hepatitis; Hepatitis B, Chronic; Hepatitis C; Herpesviridae Infections; HIV Infections; Humans; Influenza, Human; Interferons; Lamivudine; Nucleosides; Oligopeptides; Organophosphonates; Oseltamivir; Proline; Protease Inhibitors; Pyrimidinones; Ribavirin; Telbivudine; Thymidine; Valacyclovir; Valganciclovir; Valine; Virus Replication; Zanamivir | 2011 |
Promising prevention approaches: tenofovir gel and prophylactic use of antiretroviral medications.
Topics: Adenine; Anti-HIV Agents; Female; Gels; HIV Infections; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
[The past, present and future treatment for chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates; Practice Guidelines as Topic | 2011 |
[Lamivudine, adefovir dipivoxil].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2011 |
[Prevention for the development of hepatitis B virus-related hepatocellular carcinoma by anti-viral treatment].
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Organophosphonates | 2011 |
Management of severe acute to fulminant hepatitis B: to treat or not to treat or when to treat?
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B; Humans; Interferons; Lamivudine; Liver Failure, Acute; Organophosphonates; Tenofovir | 2012 |
[Pharmacological treatment of acute hepatitis B].
Topics: Acute Disease; Adenine; Antiviral Agents; Guanine; Hepatitis B; Humans; Lamivudine; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pyrimidinones; Spain; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2012 |
Elvitegravir: a once-daily, boosted, HIV-1 integrase inhibitor.
Topics: Adenine; Carbamates; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Deoxycytidine; Drug Combinations; Drug Interactions; Drug Resistance, Viral; Drug-Related Side Effects and Adverse Reactions; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV Integrase Inhibitors; HIV-1; Humans; Organophosphonates; Quinolones; Randomized Controlled Trials as Topic; Thiazoles | 2012 |
Pharmacokinetics of antiretroviral drugs in anatomical sanctuary sites: the fetal compartment (placenta and amniotic fluid).
Topics: Adenine; Adult; Amniotic Fluid; Anti-HIV Agents; Cyclohexanes; Enfuvirtide; Female; Fetal Blood; Fetus; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Maraviroc; Nevirapine; Organophosphonates; Peptide Fragments; Placenta; Pregnancy; Pregnancy Complications, Infectious; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Tenofovir; Triazoles; Viral Load; Zidovudine | 2011 |
Tenofovir-based pre-exposure prophylaxis for HIV prevention: evolving evidence.
Topics: Adenine; Administration, Oral; Administration, Topical; Anti-HIV Agents; Female; HIV Infections; HIV-1; Humans; Male; Medication Adherence; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Lamivudine with or without adefovir dipivoxil for postoperative hepatocellular carcinoma.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Organophosphonates; Postoperative Care | 2011 |
[A case of adefovir dipivoxil induced hypophosphataemic osteomalacia and literature review].
Topics: Adenine; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia | 2011 |
Quantification of serum hepatitis B surface antigen: is it useful for the management of chronic hepatitis B?
Topics: Adenine; Antiviral Agents; Biomarkers; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir; Viral Load | 2012 |
Emerging pipeline drugs for hepatitis B infection.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Design; Drugs, Investigational; Guanine; Hepatitis B Antigens; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Treatment Outcome; Virus Replication | 2011 |
Comparative meta-analysis of adefovir dipivoxil monotherapy and combination therapy of adefovir dipivoxil and lamivudine for lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic | 2012 |
Adefovir dipivoxil in chronic hepatitis B: history and current uses.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates | 2012 |
[Kidney and HIV infection].
Topics: Adenine; AIDS-Associated Nephropathy; Anti-HIV Agents; Biopsy; Black People; ErbB Receptors; Female; Genetic Predisposition to Disease; Glomerular Filtration Rate; HIV-1; Humans; Kidney; Kidney Diseases; Male; Organophosphonates; Phosphorus; Tenofovir; Virus Replication | 2012 |
Meta-analysis: oral anti-viral agents in adults with decompensated hepatitis B virus cirrhosis.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Time Factors; Treatment Outcome; Viral Load | 2012 |
Amonafide: a future in treatment of resistant and secondary acute myeloid leukemia?
Topics: Adenine; Antineoplastic Agents; Clinical Trials as Topic; Female; Humans; Leukemia, Myeloid, Acute; Male; Naphthalimides; Organophosphonates; Topoisomerase II Inhibitors | 2012 |
How to manage HIV-infected patients with chronic kidney disease in the HAART era.
Topics: Adenine; Albuminuria; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Black People; Cystatin C; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Failure, Chronic; Organophosphonates; Prevalence; Proteinuria; Risk Factors; Tenofovir; Viral Load | 2012 |
Formulation, pharmacokinetics and pharmacodynamics of topical microbicides.
Topics: Adenine; Animals; Anti-HIV Agents; Anti-Infective Agents, Local; Female; HIV; HIV Infections; Humans; Mice; Organophosphonates; Tenofovir; Treatment Outcome; Vaginal Creams, Foams, and Jellies | 2012 |
Microbicides for HIV prevention.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Anti-Infective Agents, Local; Developing Countries; Drug Delivery Systems; Drug Resistance, Viral; Female; HIV Infections; Humans; Organophosphonates; Tenofovir | 2011 |
WITHDRAWN. Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV.
Topics: Adenine; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors | 2012 |
A review of the virological efficacy of the 4 World Health Organization-recommended tenofovir-containing regimens for initial HIV therapy.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Lamivudine; Nevirapine; Organophosphonates; Tenofovir; Treatment Failure; Viral Load; World Health Organization | 2012 |
Drug delivery in multiple indication (multipurpose) prevention technologies: systems to prevent HIV-1 transmission and unintended pregnancies or HSV-2 transmission.
Topics: Adenine; Administration, Intravaginal; Anti-Infective Agents; Antiviral Agents; Biopharmaceutics; Contraception; Disease Transmission, Infectious; Drug Delivery Systems; Female; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; HIV-1; Humans; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Pregnancy, Unplanned; Tenofovir | 2012 |
Overview of microbicides for the prevention of human immunodeficiency virus.
Topics: Adenine; Anti-HIV Agents; Anti-Infective Agents; Clinical Trials as Topic; Female; HIV; HIV Infections; Humans; Organophosphonates; Tenofovir | 2012 |
HIV prevention by oral preexposure prophylaxis.
Topics: Adenine; Administration, Oral; Animals; Anti-Retroviral Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; HIV Infections; HIV Seronegativity; Humans; Male; Mucous Membrane; Organophosphonates; Protein Binding; Rectum; Tenofovir; Vagina; Virus Replication | 2012 |
A drug evaluation of 1% tenofovir gel and tenofovir disoproxil fumarate tablets for the prevention of HIV infection.
Topics: Adenine; Animals; Anti-HIV Agents; Gels; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tablets; Tenofovir | 2012 |
[Research on molecular mechanism of drug resistance of adefovir dipivoxil].
Topics: Adenine; Animals; Antiviral Agents; Drug Resistance; Hepatitis B virus; Humans; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors | 2012 |
Relative risk of renal disease among people living with HIV: a systematic review and meta-analysis.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Anti-Retroviral Agents; Chronic Disease; Female; HIV Infections; Humans; Kidney Diseases; Male; Odds Ratio; Organophosphonates; Survival Rate; Tenofovir | 2012 |
New advances in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Coinfection; Disease Progression; Drug Resistance, Viral; Female; Guanine; Guidelines as Topic; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D; HIV Infections; Humans; Interferons; Liver Cirrhosis; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Risk Factors; Tenofovir | 2012 |
Role of raltegravir in HIV-1 management.
Topics: Adenine; Animals; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV Integrase Inhibitors; HIV-1; Humans; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Tenofovir | 2012 |
Where rilpivirine meets with tenofovir, the start of a new anti-HIV drug combination era.
Topics: Adenine; Animals; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Emtricitabine; Emtricitabine, Rilpivirine, Tenofovir Drug Combination; HIV Infections; HIV-1; Humans; Nitriles; Organophosphonates; Oxazines; Pyrimidines; Rilpivirine; Tenofovir | 2012 |
New perspectives in the therapy of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Monitoring; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferons; Interleukins; Organophosphonates; Polymorphism, Genetic; Prognosis; Tenofovir | 2012 |
Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Coinfection; Deoxycytidine; Dideoxynucleosides; Disease Progression; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Emtricitabine; Hepatitis C, Chronic; HIV Infections; Homosexuality, Male; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Diseases; Male; Oligopeptides; Organophosphonates; Polyethylene Glycols; Proline; Pyrrolidinones; Raltegravir Potassium; Recombinant Proteins; Ribavirin; Serine Proteinase Inhibitors; Substance Abuse, Intravenous; Tenofovir; Treatment Outcome | 2012 |
[New drugs of treatment of patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2012 |
First-line treatment of chronic hepatitis B with entecavir or tenofovir in 'real-life' settings: from clinical trials to clinical practice.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Guanine; Hepatitis B, Chronic; Humans; Nucleosides; Nucleotides; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load | 2012 |
Osteoporosis and bone health in HIV.
Topics: Absorptiometry, Photon; Acquired Immunodeficiency Syndrome; Adenine; Alcohol Drinking; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Density; Bone Density Conservation Agents; Female; Humans; Inflammation; Male; Organophosphonates; Osteomalacia; Osteoporosis; Osteoporotic Fractures; Smoking; Tenofovir; Weight Loss | 2012 |
Tenofovir: quo vadis anno 2012 (where is it going in the year 2012)?
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2012 |
WITHDRAWN: Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV.
Topics: Adenine; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors | 2012 |
HIV-2 encephalitis: case report and literature review.
Topics: Adenine; Anti-HIV Agents; Brain; CD4 Lymphocyte Count; Deoxycytidine; Drug Combinations; Emtricitabine; Encephalitis, Viral; HIV-2; Humans; Lopinavir; Magnetic Resonance Imaging; Male; Middle Aged; Organophosphonates; Ritonavir; RNA, Viral; Tenofovir; Viral Load | 2012 |
Topical microbicides for prevention of sexually transmitted infections.
Topics: Acrylic Resins; Adenine; Administration, Topical; Agaricales; Anti-HIV Agents; Anti-Infective Agents, Local; Cellulose; Female; HIV Infections; Humans; Male; Naphthalenesulfonates; Organophosphonates; Polymers; Seaweed; Sexually Transmitted Diseases; Tenofovir | 2012 |
[HIV preexposure prophylaxis].
Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Chemoprevention; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; Humans; Male; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
The use of biomarkers for assessing HAART-associated renal toxicity in HIV-infected patients.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiretroviral Therapy, Highly Active; Biomarkers; Creatinine; Cystatin C; Fanconi Syndrome; Female; Glomerular Filtration Rate; Humans; Kidney Failure, Chronic; Kidney Tubules, Proximal; Male; Organophosphonates; Retinol-Binding Proteins; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Antiretroviral pre-exposure prophylaxis (PrEP) for preventing HIV in high-risk individuals.
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Male; Organophosphonates; Premedication; Randomized Controlled Trials as Topic; Risk; Risk-Taking; Tenofovir; Unsafe Sex | 2012 |
What primary care providers need to know about preexposure prophylaxis for HIV prevention: a narrative review.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Directive Counseling; Emtricitabine; Evidence-Based Medicine; Heterosexuality; HIV Infections; Homosexuality; Humans; Medication Adherence; Organophosphonates; Primary Health Care; Risk Assessment; Risk-Taking; Sexual Partners; Tenofovir | 2012 |
Combinational therapies for HIV: a focus on EVG/COBI/FTC/TDF.
Topics: Adenine; Anti-HIV Agents; Carbamates; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Cobicistat; Deoxycytidine; Drug Combinations; Drug Resistance, Multiple, Viral; Emtricitabine; HIV Infections; Humans; Organophosphonates; Quinolones; Tenofovir; Thiazoles | 2012 |
Update on tenofovir toxicity in the kidney.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Hepatitis B; HIV Infections; Humans; Kidney; Kidney Diseases; Organophosphonates; Risk Factors; Tenofovir | 2013 |
Considerations regarding antiretroviral chemoprophylaxis in MSM.
Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Chemoprevention; Clinical Trials as Topic; Deoxycytidine; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Leukocytes, Mononuclear; Male; Medication Adherence; Organophosphonates; Plasma; Tenofovir; Treatment Outcome | 2012 |
Current status of topical antiretroviral chemoprophylaxis.
Topics: Adenine; Administration, Intravaginal; Administration, Topical; Anilides; Anti-HIV Agents; Chemoprevention; Clinical Trials, Phase II as Topic; Female; Furans; HIV Infections; Humans; Organophosphonates; Pyrimidines; Tenofovir; Thioamides; Treatment Outcome | 2012 |
Tenofovir disoproxil fumarate in the treatment of chronic hepatitis B.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Emtricitabine/tenofovir in the treatment of HIV infection: current PK/PD evaluation.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Emtricitabine; HIV Infections; HIV-1; Humans; Organophosphonates; Practice Guidelines as Topic; Tenofovir | 2012 |
Antiretrovirals for HIV Exposure Prophylaxis.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Emtricitabine; HIV; HIV Infections; Humans; Lamivudine; Occupational Exposure; Organophosphonates; Stavudine; Tenofovir; Zidovudine | 2012 |
Oral antiretroviral chemoprophylaxis: current status.
Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Chemoprevention; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Medication Adherence; Organophosphonates; Tenofovir | 2012 |
The clinical pharmacology of antiretrovirals for HIV prevention.
Topics: Adenine; Administration, Oral; Administration, Topical; Anti-Retroviral Agents; Chemoprevention; Clinical Trials as Topic; Colon; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Organophosphonates; Tenofovir; Vagina | 2012 |
Hypophosphatemic osteomalacia induced by low-dose adefovir therapy: focus on manifestations in the skeletal system and literature review.
Topics: Adenine; Bone and Bones; Dose-Response Relationship, Drug; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Radionuclide Imaging; Tomography, X-Ray Computed | 2013 |
Rectal microbicide development.
Topics: Adenine; Administration, Rectal; Administration, Topical; Anilides; Anti-HIV Agents; Chemoprevention; Clinical Trials, Phase I as Topic; Drug-Related Side Effects and Adverse Reactions; Furans; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Tenofovir; Thioamides | 2012 |
[Comparison of peg-interferon monotherapy to peg-interferon and nucleoside analogue combination therapy for hepatitis B: a meta-analysis of randomized controlled trials].
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Randomized Controlled Trials as Topic; Treatment Outcome | 2012 |
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate single tablet for HIV-1 infection treatment.
Topics: Adenine; Anti-HIV Agents; Carbamates; Clinical Trials, Phase III as Topic; Deoxycytidine; Drug Combinations; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV Integrase Inhibitors; Humans; Organophosphonates; Quinolones; Tablets; Thiazoles; Viral Load | 2012 |
High genetic barrier nucleos(t)ide analogue(s) for prophylaxis from hepatitis B virus recurrence after liver transplantation: a systematic review.
Topics: Adenine; Antiviral Agents; DNA, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Liver Failure; Liver Transplantation; Nucleotides; Organophosphonates; Recurrence; Tenofovir; Time Factors; Treatment Outcome | 2013 |
Long-term therapy with nucleoside/nucleotide analogues for chronic hepatitis B in Asian patients.
Topics: Adenine; Antiviral Agents; Asian People; Carcinoma, Hepatocellular; Disease Progression; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Organophosphonates; Tenofovir; Treatment Outcome | 2013 |
Considerations for the long-term treatment of chronic hepatitis B with nucleos(t)ide analogs.
Topics: Adenine; Age Factors; Antiviral Agents; Comorbidity; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Life Style; Organophosphonates; Severity of Illness Index; Telbivudine; Tenofovir; Thymidine; Time Factors | 2012 |
Complete resolution of erythrodermic psoriasis in an HIV and HCV patient unresponsive to antipsoriatic treatments after highly active antiretroviral therapy (Ritonavir, Atazanavir, Emtricitabine, Tenofovir).
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Hepatitis C, Chronic; HIV Infections; Humans; Immunocompromised Host; Male; Middle Aged; Oligopeptides; Organophosphonates; Psoriasis; Pyridines; Ritonavir; Tenofovir; Treatment Outcome | 2012 |
Diagnostic and therapeutic progress of multi-drug resistance with anti-HBV nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Transplantation; Mutation; Nucleosides; Nucleotides; Organophosphonates; Prognosis; Tenofovir; Viral Load | 2012 |
Cost effectiveness of first-line oral antiviral therapies for chronic hepatitis B : a systematic review.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Guanine; Health Care Costs; Hepatitis B, Chronic; Humans; Models, Economic; Organophosphonates; Reproducibility of Results; Tenofovir | 2013 |
Intracranial hypertension following highly active antiretroviral therapy interruption in an HIV-infected woman: case report and review of the literature.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Darunavir; Decompressive Craniectomy; Dideoxynucleosides; Female; Humans; Intracranial Hypertension; Lopinavir; Medication Adherence; Meningoencephalitis; Organophosphonates; Sulfonamides; Tenofovir; Treatment Outcome | 2013 |
Letter: First-line monotherapies for chronic hepatitis B - indirect comparison between entecavir and tenofovir.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2013 |
Emtricitabine/tenofovir disoproxil fumarate: a review of its use in HIV-1 pre-exposure prophylaxis.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Patient Acceptance of Health Care; Randomized Controlled Trials as Topic; Safe Sex; Sexual Behavior; Sexuality; Tenofovir | 2013 |
Use of antiretrovirals for HIV prevention: what do we know and what don't we know?
Topics: Adenine; Administration, Oral; Administration, Topical; Anti-HIV Agents; Chemoprevention; Female; HIV Infections; Humans; Male; Medication Adherence; Organophosphonates; Randomized Controlled Trials as Topic; Risk Reduction Behavior; Sexual Behavior; Tenofovir | 2013 |
Update in the management of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Monitoring; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon Type I; Organophosphonates; Practice Guidelines as Topic; Tenofovir | 2013 |
Treatment of delta hepatitis.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Farnesyl-Diphosphate Farnesyltransferase; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D, Chronic; Hepatitis delta Antigens; Hepatitis Delta Virus; Humans; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Protein Prenylation; Recombinant Proteins; Viral Proteins; Virus Replication | 2013 |
Meta-analysis: the impact of oral anti-viral agents on the incidence of hepatocellular carcinoma in chronic hepatitis B.
Topics: Adenine; Administration, Oral; Age Factors; Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B, Chronic; Humans; Incidence; Liver Neoplasms; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2013 |
Recent findings on the mechanisms involved in tenofovir resistance.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; Drug Synergism; HIV-1; Organophosphonates; Tenofovir | 2014 |
Preexposure prophylaxis for HIV prevention: where have we been and where are we going?
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; Humans; Medication Adherence; Organophosphonates; Risk Factors; Tenofovir | 2013 |
Bone health in children and adolescents with perinatal HIV infection.
Topics: Adenine; Adolescent; Anti-HIV Agents; Bone Density; Bone Diseases; Child; HIV Infections; Humans; Organophosphonates; Prevalence; Tenofovir | 2013 |
Viral hepatitis and HIV: update and management.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Coinfection; Drug Therapy, Combination; Guanine; Hepatitis C; HIV Infections; Humans; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Protease Inhibitors; Recombinant Proteins; Ribavirin; Tenofovir | 2013 |
[Pre-exposure prophylaxis for the prevention of sexual HIV transmission; new preventative strategy using tenofovir/emtricitabine].
Topics: Adenine; Anti-HIV Agents; Chemoprevention; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Netherlands; Organophosphonates; Patient Compliance; Risk-Taking; Sexual Behavior; Tenofovir | 2013 |
[Interdisciplinary aspects of and new drugs for chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Comorbidity; Drug Interactions; Drug Therapy, Combination; Female; Gastroenterology; Guanine; Hematology; Hepatitis B, Chronic; Humans; Hungary; Infant, Newborn; Infant, Newborn, Diseases; Infectious Disease Transmission, Vertical; Interdisciplinary Communication; Interferons; Lamivudine; Medical Oncology; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Rheumatology; Tenofovir | 2013 |
Suppression of HBV by tenofovir in HBV/HIV coinfected patients: a systematic review and meta-analysis.
Topics: Adenine; Anti-HIV Agents; Coinfection; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Organophosphonates; Tenofovir | 2013 |
The Holý Trinity: the acyclic nucleoside phosphonates.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Combination; Humans; Nucleosides; Organophosphonates; Prodrugs; Tenofovir; Virus Diseases | 2013 |
Long-term results of treatment with nucleoside and nucleotide analogues (entecavir and tenofovir) for chronic hepatitis B.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Treatment Outcome; Virus Replication | 2013 |
Hepatitis B in HIV-infected patients.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Coinfection; Drug Resistance, Viral; Hepatitis B Vaccines; Hepatitis B, Chronic; Hepatitis D; HIV Infections; Humans; Lamivudine; Organophosphonates; Tenofovir | 2013 |
[Reactivation of chronic hepatitis B].
Topics: Adenine; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antiviral Agents; Biomarkers; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Immunosuppressive Agents; Inflammation; Lamivudine; Organophosphonates; Rituximab; Tenofovir; Virus Activation | 2013 |
EFV/FTC/TDF-associated hepatotoxicity: a case report and review.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Chemical and Drug Induced Liver Injury; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; Humans; Liver; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2013 |
Single-tablet regimens in HIV: does it really make a difference?
Topics: Adenine; Anti-HIV Agents; Carbamates; Cobicistat; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Emtricitabine; HIV Infections; HIV-1; Humans; Nitriles; Organophosphonates; Pyrimidines; Quinolones; Reverse Transcriptase Inhibitors; Rilpivirine; Tablets; Tenofovir; Thiazoles | 2014 |
Safety of tenofovir during pregnancy for the mother and fetus: a systematic review.
Topics: Adenine; Animals; Female; Fetal Development; HIV Infections; Humans; Infant, Newborn; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir | 2013 |
Efficacy of lamivudine combined with adefovir dipivoxil versus entecavir monotherapy in patients with hepatitis B-associated decompensated cirrhosis: A meta-analysis.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Creatinine; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Randomized Controlled Trials as Topic; Treatment Outcome | 2014 |
Options for the management of antiviral resistance during hepatitis B therapy: reflections on battles over a decade.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Nucleosides; Organophosphonates; Tenofovir; Virus Replication | 2013 |
Antiretroviral therapy, immune suppression and renal impairment in HIV-positive persons.
Topics: Adenine; Anti-Retroviral Agents; HIV Infections; Humans; Immunosuppression Therapy; Kidney Diseases; Organophosphonates; Protease Inhibitors; Tenofovir | 2014 |
Comparison of the efficacy of Lamivudine plus adefovir versus entecavir in the treatment of Lamivudine-resistant chronic hepatitis B: a systematic review and meta-analysis.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Treatment Outcome | 2013 |
[Mechanism of action and pharmacokinetics of rilpivirine].
Topics: Adenine; Adult; Aged; Animals; Anti-HIV Agents; Biological Availability; Child; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Deoxycytidine; Drug Administration Routes; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Emtricitabine; Food-Drug Interactions; Half-Life; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Intestinal Absorption; Molecular Structure; Nanoparticles; Nitriles; Organophosphonates; Proton Pump Inhibitors; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir | 2013 |
Review article: nucleos(t)ide analogues in patients with chronic hepatitis B virus infection and chronic kidney disease.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Renal Insufficiency, Chronic; Telbivudine; Tenofovir; Thymidine | 2014 |
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate single-tablet regimen (Stribild®): a review of its use in the management of HIV-1 infection in adults.
Topics: Adenine; Anti-HIV Agents; Carbamates; Deoxycytidine; Drug Combinations; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Quinolones; Tablets; Thiazoles | 2014 |
Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment.
Topics: Acidosis, Lactic; Adenine; Administration, Oral; Antiviral Agents; Arabinofuranosyluracil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Kidney Diseases; Male; Muscular Diseases; Nervous System Diseases; Nucleosides; Nucleotides; Organophosphonates; Pharmacovigilance; Pregnancy; Telbivudine; Tenofovir; Thymidine | 2014 |
Regression of fibrosis after HBV antiviral therapy. Is cirrhosis reversible?
Topics: Adenine; Administration, Oral; Antiviral Agents; Carcinoma, Hepatocellular; Fibrosis; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Telbivudine; Tenofovir; Thymidine | 2014 |
HBeAg-positive chronic hepatitis B: why do i treat my patients with Nucleos(t)ide analogs?
Topics: Adenine; Age Factors; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Precision Medicine; Recombinant Proteins; Sex Factors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2014 |
HBeAg-negative chronic hepatitis B: why do I treat my patients with nucleos(t)ide analogues?
Topics: Adenine; Age Factors; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Nucleosides; Organophosphonates; Polyethylene Glycols; Precision Medicine; Recombinant Proteins; Sex Factors; Tenofovir; Treatment Outcome | 2014 |
Impact of HBV therapy on the incidence of hepatocellular carcinoma.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Tenofovir | 2014 |
New therapeutic perspectives in HBV: when to stop NAs.
Topics: Adenine; Algorithms; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine | 2014 |
Clinical utility of entecavir for chronic hepatitis B in Chinese patients.
Topics: Adenine; Antiviral Agents; China; Cost-Benefit Analysis; Drug Resistance, Viral; Hepatitis B, Chronic; Humans; Liver Transplantation; Organophosphonates | 2013 |
Peginterferon alpha versus other antiviral regimes for Chinese HBeAg-positive chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; China; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Organophosphonates; Polyethylene Glycols | 2013 |
Systemic preexposure prophylaxis for HIV: translating clinical data to clinical practice.
Topics: Adenine; Anti-HIV Agents; Cost-Benefit Analysis; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Incidence; Medication Adherence; Organophosphonates; Risk Reduction Behavior; Safe Sex; Tenofovir | 2014 |
Hypophosphatemic osteomalacia due to drug-induced Fanconi's syndrome associated with adefovir dipivoxil treatment for hepatitis B.
Topics: Adenine; Bone Diseases, Metabolic; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia | 2014 |
Effects of hormonal contraception on antiretroviral drug metabolism, pharmacokinetics and pharmacodynamics.
Topics: Adenine; Anti-HIV Agents; Contraception; Contraceptives, Oral, Hormonal; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Deoxycytidine; Drug Interactions; Emtricitabine; Family Planning Services; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Pregnancy; Progestins; Tenofovir; Treatment Outcome | 2014 |
An update on hepatitis B, D, and E viruses.
Topics: Adenine; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Hepatitis D, Chronic; Hepatitis E; Humans; Interferon-alpha; Liver Cirrhosis; Liver Failure; Organophosphonates; Tenofovir; Treatment Outcome | 2014 |
Managing hepatitis B to prevent liver cancer: recent advances.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B, Chronic; Humans; Liver Neoplasms; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2014 |
Tenofovir, emtricitabine, and darunavir/ritonavir pharmacokinetics in an HIV-infected patient after Roux-en-Y gastric bypass surgery.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Darunavir; Deoxycytidine; Emtricitabine; Gastric Bypass; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Ritonavir; Sulfonamides; Tenofovir | 2014 |
An overview of antiretroviral pre-exposure prophylaxis of HIV infection.
Topics: Adenine; Anti-HIV Agents; Cyclohexanes; Drug Resistance, Viral; Female; HIV Infections; Humans; Male; Maraviroc; Medication Adherence; Nitriles; Organophosphonates; Pre-Exposure Prophylaxis; Pyridones; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; Triazoles | 2014 |
Efficacy and resistance in de novo combination lamivudine and adefovir dipivoxil therapy versus entecavir monotherapy for the treatment-naive patients with chronic hepatitis B: a meta-analysis.
Topics: Adenine; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Organophosphonates; Treatment Outcome | 2014 |
Advances in the treatment of hepatitis B virus/hepatitis C virus coinfection.
Topics: Adenine; Antiviral Agents; Coinfection; DNA, Viral; Drug Therapy, Combination; Guanine; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C; Hepatitis C, Chronic; HIV Infections; Humans; Organophosphonates; Ribavirin; RNA, Viral; Tenofovir; Virus Replication | 2014 |
Management of chronic hepatitis B in children: an unresolved issue.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Carrier State; Child; Databases, Bibliographic; Guanine; Hepatitis B, Chronic; Humans; Immune Tolerance; Incidence; Interferons; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Nucleosides; Organophosphonates; Risk; Tenofovir | 2014 |
Management of chronic hepatitis B infection: current treatment guidelines, challenges, and new developments.
Topics: Adenine; Antiviral Agents; Disease Management; DNA, Viral; Drug Delivery Systems; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B, Chronic; Humans; Interferons; Organophosphonates; Polyethylene Glycols; Practice Guidelines as Topic; Tenofovir; Viral Load | 2014 |
Comparison of efficacy and safety of tenofovir and entecavir in chronic hepatitis B virus infection: a systematic review and meta-analysis.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Organophosphonates; Safety; Tenofovir | 2014 |
Management of patients with overt or resolved hepatitis B virus infection undergoing rituximab therapy.
Topics: Adenine; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Carrier State; Disease Management; DNA, Viral; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Lymphoproliferative Disorders; Organophosphonates; Rituximab; Tenofovir; Virus Activation | 2014 |
Molecular diagnosis and treatment of drug-resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Molecular Diagnostic Techniques; Mutation; Nucleic Acid Hybridization; Organophosphonates; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Tenofovir; Treatment Outcome | 2014 |
Liquid oral suspension adefovir dipivoxil (GS-02-526): an update on treatments for hepatitis B infection.
Topics: Adenine; Administration, Oral; Antiviral Agents; Clinical Trials as Topic; DNA, Viral; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Evaluation, Preclinical; Hepatitis B; Humans; Organophosphonates; Suspensions; Treatment Outcome | 2014 |
Tenofovir-induced nephrotoxicity: incidence, mechanism, risk factors, prognosis and proposed agents for prevention.
Topics: Adenine; Animals; Anti-HIV Agents; HIV Infections; Humans; Incidence; Kidney Diseases; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir | 2014 |
Entecavir plus adefovir combination therapy versus lamivudine add-on adefovir for lamivudine-resistant chronic hepatitis B: A meta-analysis.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Treatment Outcome | 2014 |
Treatment of chronic hepatitis B in clinical practice with entecavir or tenofovir.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Treatment Outcome | 2014 |
[Treatment of viral hepatitis in children].
Topics: Adenine; Adolescent; Antiviral Agents; Child; Child Welfare; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Tenofovir | 2013 |
Prevention of hepatitis B virus reinfection in liver transplant recipients.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Liver; Liver Cirrhosis; Liver Transplantation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir; Transplant Recipients; Virus Replication | 2014 |
Virological efficacy of abacavir: systematic review and meta-analysis.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Emtricitabine; HIV Infections; Humans; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir; Treatment Outcome | 2014 |
48-week efficacy and safety of dolutegravir relative to commonly used third agents in treatment-naive HIV-1-infected patients: a systematic review and network meta-analysis.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV-1; Humans; Lamivudine; Lipids; Lopinavir; Nitriles; Organophosphonates; Oxazines; Piperazines; Pyridones; Pyrimidines; Pyrrolidinones; Raltegravir Potassium; Randomized Controlled Trials as Topic; Rilpivirine; Ritonavir; Tenofovir; Time Factors; Treatment Outcome; Viral Load | 2014 |
Review of tenofovir use in HIV-infected children.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Bone and Bones; Child; Child, Preschool; Drug Utilization; Drug-Related Side Effects and Adverse Reactions; HIV Infections; Humans; Kidney; Organophosphonates; Tenofovir; Young Adult | 2015 |
Breastfeeding while taking lamivudine or tenofovir disoproxil fumarate: a review of the evidence.
Topics: Adenine; Anti-HIV Agents; Breast Feeding; Disease Transmission, Infectious; Female; Hepatitis B; Humans; Infant, Newborn; Lamivudine; Organophosphonates; Pregnancy; Tenofovir | 2015 |
Microbicides and their potential as a catalyst for multipurpose sexual and reproductive health technologies.
Topics: Adenine; Anti-HIV Agents; Anti-Infective Agents; Female; Gels; HIV Infections; Humans; Male; Organophosphonates; Reproductive Health; Tenofovir; Women's Health | 2014 |
Emtricitabine/rilpivirine/tenofovir disoproxil fumarate single-tablet regimen: a review of its use in HIV infection.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; HIV-1; Humans; Nitriles; Organophosphonates; Pyrimidines; Rilpivirine; Tablets; Tenofovir | 2014 |
Treating Immune-tolerant Hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Therapy; Hepatitis B, Chronic; Humans; Interferons; Nucleotides; Organophosphonates; Tenofovir | 2015 |
Optimal therapy of chronic hepatitis B: how do I treat HBeAg-positive patients?
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Long-Term Care; Organophosphonates; Tenofovir; Treatment Outcome | 2015 |
Optimal therapy of chronic hepatitis B: how do I treat my HBeAg-negative patients?
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Long-Term Care; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir; Treatment Outcome; Virus Replication | 2015 |
The pharmacokinetics, pharmacodynamics and clinical efficacy of elvitegravir + cobicistat + emtricitabine + tenofovir combination therapy for the treatment of HIV.
Topics: Adenine; Adult; Anti-HIV Agents; Carbamates; Deoxycytidine; Drug Approval; Drug Combinations; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; European Union; HIV Infections; HIV-1; Humans; Organophosphonates; Quinolones; Tablets; Thiazoles | 2015 |
Antiretroviral drugs for prevention of mother-to-child transmission: pharmacologic considerations for a public health approach.
Topics: Adenine; Adult; Alkynes; Anti-Retroviral Agents; Benzoxazines; Child; Cyclopropanes; Drug Resistance, Viral; Drug Therapy; HIV; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lamivudine; Organophosphonates; Public Health; Tenofovir | 2014 |
Stribild: a review of component characteristics and combination drug efficacy.
Topics: Adenine; Anti-HIV Agents; Carbamates; Deoxycytidine; Drug Combinations; Drug Synergism; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Quinolones; Thiazoles | 2015 |
Current status of chemically synthesized inhibitors of Ebola virus.
Topics: Adenine; Adenosine; Amides; Antiviral Agents; Cytosine; Drug Discovery; Ebolavirus; Hemorrhagic Fever, Ebola; Humans; Organophosphonates; Patents as Topic; Purine Nucleosides; Pyrazines; Pyrrolidines | 2014 |
Pegylated interferon alfa for chronic hepatitis B: systematic review and meta-analysis.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Treatment Outcome; Viral Load | 2016 |
[The newest developments of the study on anti-HIV drugs].
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Organophosphates; Organophosphonates; Piperazines; Pyridones; Reverse Transcriptase Inhibitors; Tenofovir | 2015 |
Monotherapy for hepatitis B infection: a review of treatment options.
Topics: Adenine; Animals; Antiviral Agents; Carcinoma, Hepatocellular; Guanine; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver Neoplasms; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome | 2015 |
[Hepatitis B Virus Infection: Current Trends and Issues].
Topics: Adenine; Animals; Antiviral Agents; Carcinoma, Hepatocellular; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Organophosphonates | 2015 |
HBsAg seroclearance or seroconversion induced by peg-interferon alpha and lamivudine or adefovir combination therapy in chronic hepatitis B treatment: a meta-analysis and systematic review.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Seroconversion | 2016 |
Systematic review with network meta-analysis: Comparative efficacy of oral nucleos(t)ide analogues for the prevention of chemotherapy-induced hepatitis B virus reactivation.
Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Controlled Clinical Trials as Topic; Guanine; Hepatitis B; Hepatitis B virus; Host-Pathogen Interactions; Humans; Lamivudine; Organophosphonates; Telbivudine; Thymidine; Virus Activation | 2016 |
Chronic hepatitis B in children: Therapeutic challenges and perspectives.
Topics: Adenine; Alanine Transaminase; Antigens, Viral; Antiviral Agents; Child; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immune Tolerance; Interferon-alpha; Lamivudine; Molecular Targeted Therapy; Organophosphonates; Practice Guidelines as Topic; Seroconversion; Telbivudine; Tenofovir; Thymidine; Viral Envelope Proteins | 2017 |
A Meta-Analysis of the Efficacy of Interferon Monotherapy or Combined with Different Nucleos(t)ide Analogues for Chronic Hepatitis B.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Odds Ratio; Organophosphonates; Treatment Outcome | 2016 |
Where next with preexposure prophylaxis?
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Organophosphonates; Pre-Exposure Prophylaxis; Randomized Controlled Trials as Topic; Tenofovir | 2017 |
Relationship between nephrotoxicity and long-term adefovir dipivoxil therapy for chronic hepatitis B: A meta-analysis.
Topics: Adenine; Creatinine; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney; Kidney Diseases; Organophosphonates; Risk Factors | 2016 |
Management of Antiviral Resistance in Chronic Hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Tenofovir | 2017 |
Amino Acid Ester Prodrugs of Nucleoside and Nucleotide Antivirals.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; Humans; Nucleosides; Nucleotides; Organophosphonates; Prodrugs | 2017 |
Nucleos(t)ide analogues for preventing HBV reactivation in immunosuppressed patients with hematological malignancies: a network meta-analysis.
Topics: Adenine; Antiviral Agents; Controlled Clinical Trials as Topic; Guanine; Hematologic Neoplasms; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Lamivudine; Organophosphonates; Survival Analysis; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Activation | 2017 |
Efficacy of Nucleot(s)ide Analogs Therapy in Patients with Unresectable HBV-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Organophosphonates; Retrospective Studies; Survival Analysis; Telbivudine; Tenofovir; Thymidine | 2017 |
Combination Therapy for Chronic Hepatitis B: Current Updates and Perspectives.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Viral Load | 2017 |
Antiretroviral dose optimization: the future of efavirenz 400 mg dosing.
Topics: Adenine; Alkynes; Anti-HIV Agents; Anti-Retroviral Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Dose-Response Relationship, Drug; HIV Infections; Humans; Organophosphonates; Tenofovir; Treatment Outcome | 2017 |
Evaluation of Ion-pair Formation of Adefovir to Improve Permeation across Artificial and Biological Membranes.
Topics: Adenine; Animals; Antiviral Agents; Cell Membrane; Cetrimonium; Cetylpyridinium; Humans; Intestinal Mucosa; Ions; Organophosphonates; Prodrugs; Quaternary Ammonium Compounds | 2018 |
Comparative effectiveness of anti-viral drugs with dual activity for treating hepatitis B and HIV co-infected patients: a network meta-analysis.
Topics: Adenine; Adult; Aged; Antiviral Agents; Coinfection; Emtricitabine; Female; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Network Meta-Analysis; Organophosphonates; Tenofovir; Treatment Outcome; Young Adult | 2018 |
Bayesian Network Meta-Analysis for Assessing Adverse Effects of Anti-hepatitis B Drugs.
Topics: Adenine; Antiviral Agents; Bayes Theorem; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Network Meta-Analysis; Organophosphonates; Prospective Studies; Telbivudine; Tenofovir | 2019 |
Drugs in the Pipeline for HBV.
Topics: Adenine; Antiviral Agents; DNA, Viral; Female; Forecasting; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Assessment; Tenofovir; Treatment Outcome; Virus Replication | 2019 |
Hepatitis Delta: Prevalence, Natural History, and Treatment Options.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Biomarkers; Carcinoma, Hepatocellular; Global Health; Hepatitis D; Hepatitis delta Antigens; Hepatitis Delta Virus; Humans; Interferon alpha-2; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Organophosphonates; Prevalence; Risk; RNA, Viral; Serologic Tests | 2020 |
Fanconi syndrome induced by adefovir dipivoxil: a case report and clinical review.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Quality of Life | 2020 |
Combination of Entecavir or Tenofovir with Pegylated Interferon-α for Long-Term Reduction in Hepatitis B Surface Antigen Levels: Simultaneous, Sequential, or Add-on Combination Therapy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Genotype; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Reproducibility of Results; Tenofovir; Treatment Outcome; Viral Load | 2021 |
Economic Evaluation of Oral Nucleos(t)ide Analogues for Patients with Chronic Hepatitis B in Thailand.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Thailand; Treatment Outcome | 2022 |
Adefovir for lamivudine-resistant hepatitis B.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B; Humans; Lamivudine; Organophosphonates | 2022 |
Coordination Chemistry of Nucleotides and Antivirally Active Acyclic Nucleoside Phosphonates, including Mechanistic Considerations.
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Antiviral Agents; Chelating Agents; Ethers; Ions; Metals; Nucleosides; Nucleotides; Organophosphonates; Oxygen; Phosphates; Sugars | 2022 |
710 trial(s) available for organophosphonates and adenine
| Article | Year |
|---|---|
Use of two virustatica (AZT, PMEA) in the treatment of FIV and of FeLV seropositive cats with clinical symptoms.
Topics: Adenine; Animals; Antiviral Agents; Cats; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Feline Acquired Immunodeficiency Syndrome; Gene Products, gag; Hematocrit; Immunodeficiency Virus, Feline; Injections, Subcutaneous; Leukemia Virus, Feline; Leukemia, Feline; Organophosphonates; T-Lymphocytes, Regulatory; Zidovudine | 1992 |
Phase II trial of amonafide in previously treated patients with advanced ovarian cancer: a Southwest Oncology Group study.
Topics: Adenine; Adult; Aged; Cisplatin; Drug Administration Schedule; Drug Evaluation; Female; Humans; Imides; Isoquinolines; Middle Aged; Naphthalimides; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Organophosphonates; Ovarian Neoplasms | 1992 |
Phase II study of amonafide in advanced and recurrent sarcoma patients.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Female; Humans; Imides; Injections, Intravenous; Isoquinolines; Male; Middle Aged; Naphthalimides; Organophosphonates; Recurrence; Sarcoma; Treatment Outcome | 1992 |
Evaluation of amonafide in cervical cancer, phase II. A SWOG study.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evaluation; Female; Humans; Imides; Isoquinolines; Middle Aged; Naphthalimides; Neoplasm Recurrence, Local; Organophosphonates; Survival Analysis; Uterine Cervical Neoplasms | 1992 |
Evaluation of amonafide in refractory and relapsing multiple myeloma: a Southwest Oncology Group study.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Blood Cell Count; Drug Resistance; Female; Granulocytes; Humans; Imides; Isoquinolines; Leukopenia; Male; Middle Aged; Multiple Myeloma; Naphthalimides; Organophosphonates; Recurrence; Thrombocytopenia | 1991 |
Phase II study of amonafide in advanced pancreatic adenocarcinoma.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Organophosphonates; Pancreatic Neoplasms | 1991 |
Phase II evaluation of amonafide in renal cell carcinoma. A Southwest Oncology Group study.
Topics: Adenine; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Evaluation; Female; Humans; Imides; Isoquinolines; Kidney Neoplasms; Male; Middle Aged; Naphthalimides; Organophosphonates | 1991 |
Phase II study of amonafide in advanced breast cancer.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Cardiomyopathies; Drug Evaluation; Female; Humans; Imides; Infusions, Intravenous; Isoquinolines; Leukopenia; Middle Aged; Naphthalimides; Nausea; Organophosphonates | 1991 |
Novel chemotherapeutic agents in early clinical development.
Topics: Adenine; Alkaloids; Anthraquinones; Antineoplastic Agents; Biphenyl Compounds; Camptothecin; Humans; Imides; Irinotecan; Isoquinolines; Naphthalimides; Neoplasms; Organophosphonates; Paclitaxel; Pyrazoles; Quinazolines; Sulfonylurea Compounds; Terpenes; Trimetrexate | 1990 |
Phase I clinical investigation of benzisoquinolinedione (amonafide) in adults with refractory or relapsed acute leukemia.
Topics: Acute Disease; Adenine; Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Female; Humans; Imides; Isoquinolines; Leukemia; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthalimides; Organophosphonates; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1991 |
Phase II study of amonafide (nafidamide, NSC 308847) in advanced colorectal cancer.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Colorectal Neoplasms; Drug Evaluation; Humans; Imides; Isoquinolines; Middle Aged; Naphthalimides; Organophosphonates | 1991 |
Phase I clinical investigation of amonafide.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Drug Evaluation; Female; Half-Life; Humans; Imides; Isoquinolines; Lung Neoplasms; Male; Metabolic Clearance Rate; Middle Aged; Naphthalimides; Organophosphonates; Prostatic Neoplasms | 1989 |
Phase II study of amonafide in patients with recurrent glioma.
Topics: Adenine; Adrenal Cortex Hormones; Adult; Aged; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Female; Glioma; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Nervous System Diseases; Oligodendroglioma; Organophosphonates; Recurrence; Tomography, X-Ray Computed; Treatment Outcome | 1995 |
Population pharmacodynamic study of amonafide: a Cancer and Leukemia Group B study.
Topics: Acetylation; Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Imides; Isoquinolines; Leukopenia; Lymphoma, Non-Hodgkin; Metabolic Clearance Rate; Middle Aged; Multivariate Analysis; Naphthalimides; Organophosphonates; Racial Groups; Regression Analysis; Serum Albumin; United States | 1995 |
Phase II study of amonafide in gastric adenocarcinoma. An Illinois Cancer Center trial.
Topics: Adenine; Adenocarcinoma; Antineoplastic Agents; Female; Hematologic Diseases; Humans; Imides; Isoquinolines; Male; Naphthalimides; Organophosphonates; Stomach Neoplasms | 1994 |
Phase II trial of amonafide for the treatment of advanced, hormonally refractory carcinoma of the prostate. A Southwest Oncology Group study.
Topics: Adenine; Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Neoplasms, Hormone-Dependent; Organophosphonates; Prostatic Neoplasms; Remission Induction | 1994 |
Phase II evaluation of amonafide in advanced sarcoma: a Southwest Oncology Group study.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Nausea; Organophosphonates; Sarcoma; Soft Tissue Neoplasms; Vomiting | 1994 |
Bootstrap validation of pharmacodynamic models defined via stepwise linear regression.
Topics: Acetylation; Adenine; Aging; Female; Humans; Imides; Isoquinolines; Leukocyte Count; Leukopenia; Male; Models, Statistical; Naphthalimides; Organophosphonates; Regression Analysis; Selection Bias; Sex Factors | 1994 |
A Gynecologic Oncology Group phase II study of amonafide (NSC #308847) in squamous cell carcinoma of the cervix.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Female; Hematologic Diseases; Humans; Imides; Isoquinolines; Middle Aged; Naphthalimides; Organophosphonates; Pelvic Neoplasms; Treatment Outcome; Uterine Cervical Neoplasms | 1994 |
Advanced colorectal adenocarcinoma: treatment with amonafide.
Topics: Adenine; Antineoplastic Agents; Carcinoma; Colorectal Neoplasms; Humans; Imides; Intercalating Agents; Isoquinolines; Naphthalimides; Organophosphonates | 1994 |
Amonafide as first-line chemotherapy for metastatic breast cancer.
Topics: Adenine; Adult; Aged; Agranulocytosis; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Imides; Isoquinolines; Middle Aged; Naphthalimides; Nausea; Neoplasm Metastasis; Organophosphonates; Treatment Outcome; Vomiting | 1994 |
A Gynecologic Oncology Group phase II study of amonafide (NSC 308847) in epithelial ovarian cancer.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Carcinoma; Female; Humans; Imides; Isoquinolines; Middle Aged; Naphthalimides; Organophosphonates; Ovarian Neoplasms | 1993 |
Phase II trial of amonafide in patients with advanced metastatic or recurrent endometrial adenocarcinoma. A Southwest Oncology Group study.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Endometrial Neoplasms; Female; Humans; Imides; Intercalating Agents; Isoquinolines; Middle Aged; Naphthalimides; Neoplasm Recurrence, Local; Organophosphonates; Survival Analysis; Treatment Outcome | 1994 |
Amonafide treatment of refractory esophageal cancer. A Southwest Oncology Group study.
Topics: Adenine; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Drugs, Investigational; Esophageal Neoplasms; Female; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Organophosphonates; Prognosis | 1993 |
A randomized phase II trial of amonafide or trimetrexate in patients with advanced non-small cell lung cancer. A trial of the North Central Cancer Treatment Group.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Imides; Isoquinolines; Lung Neoplasms; Male; Middle Aged; Naphthalimides; Neoplasm Staging; Organophosphonates; Trimetrexate | 1993 |
Phase II trial of amonafide in advanced colorectal cancer: a SouthWest Oncology Group study.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Female; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Organophosphonates | 1993 |
Phase I study of amonafide dosing based on acetylator phenotype.
Topics: Acetylation; Adenine; Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Imides; Intercalating Agents; Isoquinolines; Lymphoma; Male; Middle Aged; Models, Biological; Naphthalimides; Neoplasms; Organophosphonates; Phenotype | 1993 |
Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Biological Availability; Female; Half-Life; HIV Infections; HIV-1; Humans; Injections, Intravenous; Injections, Subcutaneous; Male; Middle Aged; Organophosphonates; Protein Binding | 1995 |
Phase II trial of gallium nitrate, amonafide and teniposide in metastatic non-small cell lung cancer. An Eastern Cooperative Oncology Group study (E2588).
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drugs, Investigational; Female; Gallium; Humans; Imides; Infusions, Intravenous; Isoquinolines; Longitudinal Studies; Lung Neoplasms; Male; Middle Aged; Naphthalimides; Organophosphonates; Survival Rate; Teniposide | 1995 |
Clinical pharmacokinetics of amonafide (NSC 308847) in 62 patients.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Imides; Isoquinolines; Male; Mathematics; Metabolic Clearance Rate; Middle Aged; Models, Biological; Naphthalimides; Neoplasms; Organophosphonates; Polymorphism, Genetic | 1996 |
Phase II study of amonafide in the treatment of patients with advanced squamous cell carcinoma of the head and the neck. An Illinois Cancer Center study.
Topics: Adenine; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Organophosphonates; Treatment Outcome | 1995 |
Safety of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in patients with human immunodeficiency virus infection: a pilot study.
Topics: Acquired Immunodeficiency Syndrome; Adenine; AIDS-Related Complex; Alanine Transaminase; Aspartate Aminotransferases; CD4-Positive T-Lymphocytes; HIV Infections; Humans; Immunosuppressive Agents; Injections, Intravenous; Leukocyte Count; Organophosphonates | 1996 |
A phase II trial of amonafide, caracemide, and homoharringtonine in the treatment of patients with advanced renal cell cancer.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Female; Harringtonines; Homoharringtonine; Humans; Hydroxyurea; Imides; Isoquinolines; Kidney Neoplasms; Male; Middle Aged; Naphthalimides; Organophosphonates; Survival Rate; Treatment Outcome | 1996 |
An ECOG phase II study of amonafide in unresectable or recurrent carcinoma of the head and neck (PB390). Eastern Cooperative Oncology Group.
Topics: Adenine; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Organophosphonates | 1997 |
Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Carnitine; Digestive System; Double-Blind Method; Female; HIV Core Protein p24; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; RNA, Viral | 1997 |
A phase II trial of amonafide in patients with nonsquamous cell carcinoma of the cervix. A Gynecologic Oncology Group study.
Topics: Adenine; Adult; Antineoplastic Agents; Carcinoma; Female; Humans; Imides; Isoquinolines; Middle Aged; Naphthalimides; Organophosphonates; Uterine Cervical Neoplasms | 1997 |
The safety and efficacy of adefovir dipivoxil, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults: a randomized, double-blind, placebo-controlled trial.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Carnitine; CD4 Lymphocyte Count; Cytomegalovirus; Cytomegalovirus Infections; DNA, Viral; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Lymphocyte Count; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; RNA, Viral; Semen; Sequence Analysis, RNA; T-Lymphocyte Subsets | 1997 |
[Comparative investigation of the efficacy of two nucleocapsid analogs in FIV infected cats].
Topics: Adenine; Animals; Antiviral Agents; Cats; Double-Blind Method; Feline Acquired Immunodeficiency Syndrome; Immunodeficiency Virus, Feline; Organophosphonates; Organophosphorus Compounds; Placebos; Treatment Outcome | 1997 |
Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus.
Topics: Adenine; Animals; Antiviral Agents; Cats; CD4 Lymphocyte Count; Double-Blind Method; Feline Acquired Immunodeficiency Syndrome; Female; Karnofsky Performance Status; Male; Organophosphonates; Placebos; Reference Standards; Stomatitis; Viral Load | 1998 |
Amonafide in patients with leiomyosarcoma of the uterus: a phase II Gynecologic Oncology Group study.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Female; Humans; Imides; Isoquinolines; Leiomyosarcoma; Middle Aged; Naphthalimides; Organophosphonates; Uterine Neoplasms | 1998 |
A phase II trial of amonafide in patients with mixed mesodermal tumors of the uterus: a Gynecologic Oncology Group study.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Female; Humans; Imides; Isoquinolines; Leukopenia; Middle Aged; Mixed Tumor, Mesodermal; Naphthalimides; Organophosphonates; Thrombocytopenia; Uterine Neoplasms | 1998 |
Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from AIDS patients after prolonged adefovir dipivoxil therapy.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Drug Resistance, Microbial; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Organophosphonates; Phenotype; Recombination, Genetic; Viral Load; Zidovudine | 1998 |
A phase II trial of amonafide in patients with endometrial cancer: a Gynecologic Oncology Group Study.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Endometrial Neoplasms; Female; Humans; Imides; Isoquinolines; Middle Aged; Naphthalimides; Organophosphonates | 1998 |
Safety, pharmacokinetics, and antiretroviral activity of intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a novel anti-human immunodeficiency virus (HIV) therapy, in HIV-infected adults.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Double-Blind Method; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; RNA, Viral; T-Lymphocytes; Tenofovir | 1998 |
Amonafide: An active agent in the treatment of previously untreated advanced breast cancer--a cancer and leukemia group B study (CALGB 8642).
Topics: Adenine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Fluorouracil; Humans; Imides; Isoquinolines; Menopause; Middle Aged; Naphthalimides; Neoplasm Metastasis; Organophosphonates; Receptors, Estrogen | 1995 |
Human immunodeficiency virus type 1 expressing the lamivudine-associated M184V mutation in reverse transcriptase shows increased susceptibility to adefovir and decreased replication capability in vitro.
Topics: Adenine; Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; In Vitro Techniques; Lamivudine; Organophosphonates; Point Mutation; Reverse Transcriptase Inhibitors; Virus Replication; Zidovudine | 1999 |
Safety and efficacy of using a single agent or a phase II agent before instituting standard combination chemotherapy in previously untreated metastatic breast cancer patients: report of a randomized study--Cancer and Leukemia Group B 8642.
Topics: Adenine; Adult; Aged; Aminoglycosides; Analysis of Variance; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Follow-Up Studies; Humans; Imides; Isoquinolines; Melphalan; Middle Aged; Naphthalimides; Neoplasm Staging; Organophosphonates; Prospective Studies; Survival Analysis; Trimetrexate | 1999 |
Biphasic clearance kinetics of hepatitis B virus from patients during adefovir dipivoxil therapy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Half-Life; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Models, Biological; Organophosphonates; Time Factors; Viral Load | 1999 |
A placebo-controlled phase I/II study of adefovir dipivoxil in patients with chronic hepatitis B virus infection.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Organophosphonates; Treatment Outcome; Viral Load; Viremia | 1999 |
Effect of weekly adefovir (PMEA) infusions on HIV-1 virus load: results of a phase I/II study.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Antiviral Agents; CD4 Lymphocyte Count; HIV-1; Humans; Male; Middle Aged; Organophosphonates; RNA, Viral | 1999 |
Single-dose pharmacokinetics and safety of the oral antiviral compound adefovir dipivoxil in children infected with human immunodeficiency virus type 1. The Pediatrics AIDS Clinical Trials Group.
Topics: Adenine; Adolescent; Antiviral Agents; Area Under Curve; Child; Child, Preschool; Female; Half-Life; HIV Infections; HIV-1; Humans; Infant; Male; Organophosphonates | 2000 |
Randomized study of saquinavir with ritonavir or nelfinavir together with delavirdine, adefovir, or both in human immunodeficiency virus-infected adults with virologic failure on indinavir: AIDS Clinical Trials Group Study 359.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Delavirdine; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Nelfinavir; Organophosphonates; Prospective Studies; Ritonavir; RNA, Viral; Saquinavir | 2000 |
Competing drug-drug interactions among multidrug antiretroviral regimens used in the treatment of HIV- infected subjects: ACTG 884.
Topics: Adenine; Adult; Anti-HIV Agents; Delavirdine; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Nelfinavir; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir | 2000 |
Hepatitis B and adefovir depivoxil.
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; Controlled Clinical Trials as Topic; Hepatitis B; Hepatitis B virus; Humans; Organophosphonates; Treatment Outcome | 1997 |
And also, "adefovir dipovixil".
Topics: Adenine; Antiviral Agents; Biological Availability; CD4 Lymphocyte Count; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 1996 |
PMPA trials recruiting.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Therapy, Combination; HIV Infections; Humans; Hydroxyurea; Organophosphonates; Organophosphorus Compounds; Tenofovir; Viral Load | 1998 |
Adefovir and tenofovir susceptibilities of HIV-1 after 24 to 48 weeks of adefovir dipivoxil therapy: genotypic and phenotypic analyses of study GS-96-408.
Topics: Adenine; Anti-HIV Agents; Double-Blind Method; Genes, Viral; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir | 2001 |
The safety and efficacy of adefovir dipivoxil in patients with advanced HIV disease: a randomized, placebo-controlled trial.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Cytomegalovirus Infections; Double-Blind Method; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Viral | 2001 |
Phase i/ii trial of the pharmacokinetics, safety, and antiretroviral activity of tenofovir disoproxil fumarate in human immunodeficiency virus-infected adults.
Topics: Adenine; Adult; Anti-HIV Agents; Double-Blind Method; Drug Tolerance; Female; Genotype; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; RNA, Viral; Tenofovir | 2001 |
HIV protease inhibitor substitution in patients with lipodystrophy: a randomized, controlled, open-label, multicentre study.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Body Composition; Carnitine; Dideoxynucleosides; Drug Administration Schedule; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Hydroxyurea; Insulin Resistance; Lipodystrophy; Male; Middle Aged; Nevirapine; Organophosphonates; Quality of Life; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome | 2001 |
Hydroxyurea does not enhance the anti-HIV activity of low-dose tenofovir disoproxil fumarate.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Hydroxyurea; Male; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2001 |
Tenofovir helps experienced patients.
Topics: Adenine; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
Phase II trial of amonafide in central nervous system tumors: a Southwest Oncology Group study.
Topics: Adenine; Adult; Antineoplastic Agents; Central Nervous System Neoplasms; Drug Administration Schedule; Female; Humans; Imides; Infusions, Intravenous; Isoquinolines; Male; Naphthalimides; Organophosphonates | 2002 |
Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DF.
Topics: Adenine; Double-Blind Method; Drug Resistance, Viral; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; RNA, Viral; Tenofovir; Time Factors | 2002 |
Tenofovir DF in antiretroviral-experienced patients: results from a 48-week, randomized, double-blind study.
Topics: Adenine; Adult; CD4 Lymphocyte Count; Double-Blind Method; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Organophosphorus Compounds; RNA, Viral; Tenofovir; Time Factors | 2002 |
Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Carbamates; CD4 Lymphocyte Count; Cyclopropanes; Dideoxynucleosides; Disease Progression; Double-Blind Method; Drug Resistance, Viral; Female; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Nelfinavir; Organophosphonates; Oxazines; Proportional Hazards Models; Reverse Transcriptase Inhibitors; Saquinavir; Sulfonamides; Treatment Failure; Viral Load | 2002 |
Resistance surveillance in chronic hepatitis B patients treated with adefovir dipivoxil for up to 60 weeks.
Topics: Adenine; Adult; Antiviral Agents; Base Sequence; Carcinoma, Hepatocellular; Conserved Sequence; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Mutagenesis; Organophosphonates; Phenotype; Sequence Analysis, DNA; Tumor Cells, Cultured; Viral Load; Virus Replication | 2002 |
Once-daily quadruple-drug therapy with adefovir dipivoxil, Lamivudine, Didanosine, and efavirenz in treatment-naive human immunodeficiency virus type 1-infected patients.
Topics: Adenine; Adult; Alkynes; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Didanosine; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Kidney Diseases; Lamivudine; Male; Organophosphonates; Oxazines; Pulse Therapy, Drug; Reverse Transcriptase Inhibitors; RNA, Viral; Time Factors; Treatment Outcome | 2002 |
Activity of tenofovir on hepatitis B virus replication in HIV-co-infected patients failing or partially responding to lamivudine.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2002 |
A randomized placebo-controlled trial of adefovir dipivoxil in advanced HIV infection: the ADHOC trial.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Antiviral Agents; Body Weight; CD4 Lymphocyte Count; Double-Blind Method; Drug Therapy, Combination; Fanconi Syndrome; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Male; Organophosphonates; RNA, Viral; Treatment Outcome | 2002 |
Tenofovir disoproxil fumarate therapy for chronic hepatitis B in human immunodeficiency virus/hepatitis B virus-coinfected individuals for whom interferon-alpha and lamivudine therapy have failed.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Cohort Studies; Drug Therapy, Combination; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Middle Aged; Organophosphonates; Organophosphorus Compounds; Pilot Projects; Tenofovir; Time Factors; Viral Load | 2002 |
An open-label study of tenofovir in HIV-1 and Hepatitis B virus co-infected individuals.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Lymphocyte Count; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2003 |
Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; Biopsy; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates | 2003 |
Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates | 2003 |
Treatment with indinavir, efavirenz, and adefovir after failure of nelfinavir therapy.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Middle Aged; Nelfinavir; Organophosphonates; Oxazines; Treatment Failure | 2003 |
Determining the relative efficacy of highly active antiretroviral therapy.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cohort Studies; Cyclopropanes; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Organophosphonates; Organophosphorus Compounds; Oxazines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome | 2003 |
Extended treatment with tenofovir disoproxil fumarate in treatment-experienced HIV-1-infected patients: genotypic, phenotypic, and rebound analyses.
Topics: Adenine; Adult; Anti-HIV Agents; Double-Blind Method; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; RNA, Viral; Tenofovir | 2003 |
Determining the antiviral activity of tenofovir disoproxil fumarate in treatment-naive chronically HIV-1-infected individuals.
Topics: Adenine; Adult; Anti-HIV Agents; Chronic Disease; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Viral Load | 2003 |
Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Base Sequence; Conserved Sequence; DNA, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Phenotype; Prospective Studies | 2003 |
Hepatitis B virus genotypes and virologic response in 694 patients in phase III studies of adefovir dipivoxil1.
Topics: Adenine; Adult; Antiviral Agents; Asia; DNA, Viral; Europe; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; North America; Organophosphonates; Pacific Islands; Phylogeny; Prevalence; Racial Groups; Retrospective Studies | 2003 |
Evolution of lipid abnormalities in patients switched from stavudine- to tenofovir-containing regimens.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Double-Blind Method; Female; HIV Infections; Humans; Lipids; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; RNA, Viral; Stavudine; Tenofovir | 2003 |
Tenofovir poses risk with didanosine.
Topics: Adenine; Anti-HIV Agents; Contraindications; Didanosine; Drug Administration Schedule; Humans; Organophosphonates; Organophosphorus Compounds; Pancreatitis; Tenofovir | 2003 |
Tenofovir disoproxil fumarate in nucleoside-resistant HIV-1 infection: a randomized trial.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Double-Blind Method; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Male; Mutation; Organophosphonates; Organophosphorus Compounds; Placebos; RNA; Tenofovir; Viral Load | 2003 |
GlaxoSmithKline halts AIDS study.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Dideoxynucleosides; Drug Industry; Drug Therapy, Combination; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; Treatment Failure | 2003 |
Change to abacavir-lamivudine-tenofovir combination treatment in patients with HIV-1 who had complete virological suppression.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2003 |
Single-dose and steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency virus-infected children.
Topics: Adenine; Adolescent; Anti-HIV Agents; Area Under Curve; Child; Child, Preschool; Drug Combinations; Female; Half-Life; HIV Infections; Humans; Male; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Amino Acid Motifs; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Viral Proteins | 2004 |
Adefovir dipivoxil alone or in combination with lamivudine in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
Evolution of hepatitis B viral load and viral genome sequence during adefovir dipivoxil therapy.
Topics: Adenine; Alanine Transaminase; Amino Acid Sequence; Antigens, Viral; Antiviral Agents; Biopsy; DNA-Directed DNA Polymerase; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Evolution, Molecular; Genes, Viral; Hepatitis B; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Liver; Molecular Sequence Data; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Viral Load | 2004 |
A randomized trial of nelfinavir and abacavir in combination with efavirenz and adefovir dipivoxil in HIV-1-infected persons with virological failure receiving indinavir.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Alkynes; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; HIV-1; Humans; Indinavir; Male; Nelfinavir; Organophosphonates; Oxazines; Phenotype; Reverse Transcriptase Inhibitors; Treatment Failure | 2003 |
Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Double-Blind Method; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Multivariate Analysis; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Placebos; Predictive Value of Tests; Regression Analysis; RNA, Viral; Tenofovir; Thymidine | 2004 |
Sex-based differences in saquinavir pharmacology and virologic response in AIDS Clinical Trials Group Study 359.
Topics: Adenine; Adult; Anti-HIV Agents; Delavirdine; Double-Blind Method; Drug Therapy, Combination; Female; HIV; HIV Infections; Humans; Male; Middle Aged; Nelfinavir; Organophosphonates; Ritonavir; RNA, Viral; Saquinavir; Sex Factors | 2004 |
Efficacy of tenofovir disoproxil fumarate in antiretroviral therapy-naive and -experienced patients coinfected with HIV-1 and hepatitis B virus.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Male; Mutation; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
Renal safety of tenofovir in HIV treatment-experienced patients.
Topics: Adenine; Adult; Anti-HIV Agents; Double-Blind Method; Female; HIV Infections; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Interactions between atazanavir-ritonavir and tenofovir in heavily pretreated human immunodeficiency virus-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Atazanavir Sulfate; Chromatography, High Pressure Liquid; Drug Interactions; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Oligopeptides; Organophosphonates; Organophosphorus Compounds; Pyridines; Ritonavir; Spectrophotometry, Ultraviolet; Tenofovir | 2004 |
Tenofovir treatment in an unselected cohort of highly antiretroviral experienced HIV positive patients.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Outcome | 2004 |
Efficacy and safety of tenofovir DF vs stavudine in combination therapy in antiretroviral-naive patients: a 3-year randomized trial.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Double-Blind Method; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Oxazines; Prospective Studies; Stavudine; Tenofovir; Viral Load | 2004 |
Genotypic determinants of the virological response to tenofovir disoproxil fumarate in nucleoside reverse transcriptase inhibitor-experienced patients.
Topics: Adenine; Codon; Cohort Studies; France; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Multivariate Analysis; Organophosphonates; Point Mutation; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir | 2004 |
Safety and efficacy of once-daily didanosine, tenofovir and nevirapine as a simplification antiretroviral approach.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-CD8 Ratio; Chemical and Drug Induced Liver Injury; Didanosine; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lipids; Male; Nevirapine; Organophosphonates; Pancreatitis; Patient Compliance; Quality of Life; RNA, Viral; Tenofovir | 2004 |
Renal safety of adefovir dipivoxil in patients with chronic hepatitis B: two double-blind, randomized, placebo-controlled studies.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Double-Blind Method; Female; Glycosuria; Hematuria; Hepatitis B, Chronic; Humans; Kidney; Male; Middle Aged; Organophosphonates; Phosphorus; Proteinuria | 2004 |
Effect of tenofovir disoproxil fumarate on the pharmacokinetics and pharmacodynamics of total, R-, and S-methadone.
Topics: Adenine; Adult; Area Under Curve; Chromatography, High Pressure Liquid; Confidence Intervals; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Narcotics; Organophosphonates; Organophosphorus Compounds; Stereoisomerism; Substance-Related Disorders; Tenofovir | 2004 |
Selection of K65R mutation in HIV-2-infected patients receiving tenofovir-containing regimen.
Topics: Adenine; Cohort Studies; Drug Therapy, Combination; France; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-2; Humans; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Time Factors | 2004 |
Ninety-six-week efficacy of combination therapy with lamivudine and tenofovir in patients coinfected with HIV-1 and wild-type hepatitis B virus.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; Hepatitis B; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir | 2004 |
Patterns of resistance emerging in HIV-1 from antiretroviral-experienced patients undergoing intensification therapy with tenofovir disoproxil fumarate.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Amino Acid Substitution; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; HIV Infections; HIV-1; Humans; Organophosphonates; Phenotype; Placebos; Polymorphism, Single Nucleotide; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Tenofovir | 2004 |
Comparison of adefovir and tenofovir in the treatment of lamivudine-resistant hepatitis B virus infection.
Topics: Adenine; Adult; Drug Resistance, Viral; Female; Hepatitis B, Chronic; HIV Infections; Humans; Immunosuppressive Agents; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
New once-daily HIV combination better tolerated.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Lamivudine; Organophosphonates; Oxazines; Tenofovir; Zidovudine | 2004 |
Saquinavir trough concentration before and after switching NRTI to tenofovir in patients treated with once-daily saquinavir hard gel capsule/ritonavir 1600 mg/100 mg.
Topics: Adenine; Adult; Capsules; Drug Administration Schedule; Drug Therapy, Combination; Gels; HIV Infections; HIV Protease Inhibitors; Humans; Organophosphonates; Ritonavir; Saquinavir; Tenofovir | 2004 |
Pharmacokinetic study of tenofovir disoproxil fumarate combined with rifampin in healthy volunteers.
Topics: Adenine; Adult; Antibiotics, Antitubercular; Antiviral Agents; Chromatography, High Pressure Liquid; Drug Combinations; Drug Interactions; Female; Humans; Male; Middle Aged; Organophosphonates; Rifampin; Spectrometry, Fluorescence; Tenofovir | 2005 |
Tenofovir regimen compared with Combivir.
Topics: Adenine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Europe; Female; Follow-Up Studies; HIV Infections; Humans; Lamivudine; Male; Maximum Tolerated Dose; Organophosphonates; Risk Assessment; Severity of Illness Index; Single-Blind Method; Tenofovir; Treatment Outcome; United States; Viral Load; Zidovudine | 2005 |
Long-term renal safety of tenofovir disoproxil fumarate in antiretroviral-naive HIV-1-infected patients. Data from a double-blind randomized active-controlled multicentre study.
Topics: Adenine; Adult; Double-Blind Method; Female; HIV Infections; HIV-1; Humans; Kidney Diseases; Male; Organophosphonates; Tenofovir; Time Factors | 2005 |
Early virological failure with a combination of tenofovir, didanosine and efavirenz.
Topics: Adenine; Adult; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Didanosine; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Mutation; Organophosphonates; Oxazines; Pyrimidinones; RNA, Viral; Tenofovir; Time Factors; Treatment Failure; Viremia | 2005 |
Changes in renal function associated with tenofovir disoproxil fumarate treatment, compared with nucleoside reverse-transcriptase inhibitor treatment.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Creatinine; Female; HIV Infections; Humans; Kidney Diseases; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Paradoxical CD4+ T-cell decline in HIV-infected patients with complete virus suppression taking tenofovir and didanosine.
Topics: Adenine; Adult; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Didanosine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; HIV Infections; Humans; Lymphopenia; Male; Organophosphonates; Retrospective Studies; Tenofovir; Virus Replication | 2005 |
Atazanavir plus ritonavir or saquinavir, and lopinavir/ritonavir in patients experiencing multiple virological failures.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Cholesterol; Drug Administration Schedule; Drug Resistance, Multiple, Viral; HIV Infections; HIV-1; Humans; Lipids; Lopinavir; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Saquinavir; Tenofovir; Viral Load | 2005 |
High virological failure rate in HIV patients after switching to a regimen with two nucleoside reverse transcriptase inhibitors plus tenofovir.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Didanosine; Drug Resistance, Multiple, Viral; Female; Follow-Up Studies; HIV-1; Humans; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Failure; Viral Load; Zidovudine | 2005 |
Tenofovir in chronic hepatitis B.
Topics: Adenine; Adult; Aged; Hepatitis B, Chronic; Humans; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patients.
Topics: Adenine; Anti-HIV Agents; Cell Count; Chromatography, Liquid; Cross-Sectional Studies; Didanosine; Half-Life; HIV Infections; HIV-1; Humans; Kinetics; Longitudinal Studies; Mass Spectrometry; Organophosphonates; Phosphorylation; Reference Standards; Tenofovir | 2005 |
The steady-state pharmacokinetics of nelfinavir in combination with tenofovir in HIV-infected patients.
Topics: Adenine; Adult; Aged; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Male; Middle Aged; Nelfinavir; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors | 2005 |
Long-term hepatitis B virus dynamics in HIV-hepatitis B virus-co-infected patients treated with tenofovir disoproxil fumarate.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; DNA, Viral; Epidemiologic Methods; Female; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Load; Virus Replication | 2005 |
Development and validation of a liquid chromatography/tandem mass spectrometry procedure for the quantification of adefovir in human plasma.
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Organophosphonates; Reference Standards; Reproducibility of Results; Solutions; Spectrophotometry, Ultraviolet | 2005 |
Liver transplantation for chronic hepatitis B with lamivudine-resistant YMDD mutant using add-on adefovir dipivoxil plus lamivudine.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunization, Passive; Immunoglobulins; Lamivudine; Liver Failure; Liver Transplantation; Male; Middle Aged; Mutation; Organophosphonates; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Treatment Outcome | 2005 |
Viral dynamics during tenofovir therapy in patients infected with lamivudine-resistant hepatitis B virus mutants.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Models, Biological; Organophosphonates; Tenofovir; Viral Load; Virus Replication | 2005 |
Determinants of early mortality and benefits of lamivudine therapy in patients with hepatitis B virus-related decompensated liver cirrhosis.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatic Encephalopathy; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Mutation; Organophosphonates; Survival Analysis; Taiwan | 2005 |
Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Animals; Antiviral Agents; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Prospective Studies; Time Factors | 2005 |
Early virologic failure in HIV-1 infected subjects on didanosine/tenofovir/efavirenz: 12-week results from a randomized trial.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Didanosine; Drug Combinations; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Oxazines; Tenofovir; Treatment Failure | 2005 |
Comparative selection of the K65R and M184V/I mutations in human immunodeficiency virus type 1-infected patients enrolled in a trial of first-line triple-nucleoside analog therapy (Tonus IMEA 021).
Topics: Adenine; Dideoxynucleosides; Drug Administration Schedule; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Pilot Projects; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Sequence Analysis, Protein; Tenofovir; Treatment Failure; Viral Load | 2005 |
Systemic and renal pharmacokinetics of adefovir and tenofovir upon coadministration.
Topics: Adenine; Adolescent; Adult; Area Under Curve; Drug Interactions; Female; Half-Life; Humans; Kidney; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Compromised immunologic recovery in treatment-experienced patients with HIV infection receiving both tenofovir disoproxil fumarate and didanosine in the TORO studies.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Didanosine; Drug Therapy, Combination; Enfuvirtide; HIV Envelope Protein gp41; HIV Infections; Humans; Organophosphonates; Peptide Fragments; Tenofovir; Time Factors; Viral Load | 2005 |
Is tenofovir involved in hypophosphatemia and decrease of tubular phosphate reabsorption in HIV-positive adults?
Topics: Adenine; Adult; Anti-HIV Agents; Cross-Sectional Studies; Female; HIV Infections; Humans; Hypophosphatemia; Kidney Tubules, Proximal; Male; Middle Aged; Organophosphonates; Phosphates; Tenofovir | 2006 |
Selection of hepatitis B virus polymerase mutations in HIV-coinfected patients treated with tenofovir.
Topics: Adenine; Adult; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Models, Molecular; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Selection, Genetic; Tenofovir | 2005 |
Adefovir dipivoxil alone or in combination with ongoing lamivudine in patients with decompensated liver disease and lamivudine-resistant hepatitis B virus.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Antiviral Agents; Drug Combinations; Drug Resistance, Viral; Female; Hepatitis B; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2005 |
Pharmacokinetics of pradefovir and PMEA in healthy volunteers after oral dosing of pradefovir.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Dietary Fats; Double-Blind Method; Food-Drug Interactions; Humans; Male; Organophosphonates; Organophosphorus Compounds; Prodrugs | 2005 |
Clinical and virological response to adefovir dipovixil for lamivudine-resistant HBeAg-negative hepatitis B.
Topics: Adenine; Administration, Oral; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Viremia | 2005 |
Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Time Factors; Treatment Failure | 2005 |
Efficacy and safety of adefovir dipivoxil in kidney recipients, hemodialysis patients, and patients with renal insufficiency.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Transplantation; Male; Middle Aged; Organophosphonates; Renal Dialysis; Renal Insufficiency; Viremia | 2005 |
Drug-drug and drug-food interactions between tenofovir disoproxil fumarate and didanosine.
Topics: Adenine; Adult; Anti-HIV Agents; Didanosine; Drug Interactions; Drug Therapy, Combination; Female; Food-Drug Interactions; Humans; Male; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy for pediatric HIV infection.
Topics: Adenine; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Child; Child, Preschool; Drug Resistance, Viral; Female; HIV Infections; Humans; Male; Organophosphonates; Salvage Therapy; Tenofovir; Viral Load | 2005 |
Simplification therapy with once-daily didanosine, tenofovir and efavirenz in HIV-1-infected adults with viral suppression receiving a more complex antiretroviral regimen: final results of the EFADITE trial.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Didanosine; Dose-Response Relationship, Drug; HIV Infections; HIV-1; Humans; Male; Middle Aged; Odds Ratio; Organophosphonates; Oxazines; Prospective Studies; RNA, Viral; Tenofovir; Treatment Outcome | 2005 |
[Safety and tolerance study of single oral dose of adefovir dipivoxil tablets in healthy volunteers].
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Diarrhea; Dose-Response Relationship, Drug; Female; Humans; Male; Nausea; Organophosphonates; Tablets; Young Adult | 2005 |
Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV.
Topics: Adenine; Adolescent; Adult; Aged; Alkynes; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Deoxycytidine; Emtricitabine; Female; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Oxazines; Prospective Studies; RNA, Viral; Tenofovir; Zidovudine | 2006 |
Improvement in dyslipidaemia after switching stavudine to tenofovir and replacing protease inhibitors with efavirenz in HIV-infected children.
Topics: Adenine; Adolescent; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Child; Cyclopropanes; Dyslipidemias; Female; HIV Infections; HIV-1; Humans; Lipids; Male; Organophosphonates; Oxazines; Protease Inhibitors; Stavudine; Tenofovir; Treatment Outcome; Viral Load | 2005 |
Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Female; Genotype; HIV Infections; Humans; Middle Aged; Organophosphonates; Patient Compliance; Sexual Abstinence; Tenofovir; Vaginal Creams, Foams, and Jellies | 2006 |
96-week comparison of once-daily atazanavir/ritonavir and twice-daily lopinavir/ritonavir in patients with multiple virologic failures.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Didanosine; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lipids; Lopinavir; Male; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Ritonavir; RNA, Viral; Saquinavir; Tenofovir; Time Factors; Treatment Outcome | 2006 |
Increased antiretroviral potency by the addition of enfuvirtide to a four-drug regimen in antiretroviral-naive, HIV-infected patients.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Drug Synergism; Drug Therapy, Combination; Enfuvirtide; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; Humans; Lamivudine; Lopinavir; Organophosphonates; Oxazines; Patient Compliance; Peptide Fragments; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome | 2006 |
An open-label, randomized comparative pilot study of a single-class quadruple therapy regimen versus a 2-class triple therapy regimen for individuals initiating antiretroviral therapy.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Zidovudine | 2006 |
Pharmacokinetics of tenofovir disoproxil fumarate and ritonavir-boosted saquinavir mesylate administered alone or in combination at steady state.
Topics: Adenine; Adult; Anti-HIV Agents; Area Under Curve; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Organophosphonates; Ritonavir; Saquinavir; Tenofovir | 2006 |
Absence of clinically relevant pharmacokinetic interaction between ribavirin and tenofovir in healthy subjects.
Topics: Adenine; Adult; Antiviral Agents; Drug Interactions; Female; Hepatitis C; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Ribavirin; Tenofovir | 2006 |
Salvage therapy with atazanavir/ritonavir combined to tenofovir in HIV-infected patients with multiple treatment failures: randomized ANRS 107 trial.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Salvage Therapy; Tenofovir; Treatment Failure | 2006 |
Changes in viral loads of lamivudine-resistant mutants and evolution of HBV sequences during adefovir dipivoxil therapy.
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Evolution, Molecular; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Hepatitis B; Hepatitis B virus; Humans; Interferons; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Viral Load | 2006 |
Virological response to a triple nucleoside/nucleotide analogue regimen over 48 weeks in HIV-1-infected adults in Africa.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Developing Countries; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; RNA, Viral; Tenofovir; Treatment Outcome; Uganda; Viral Load; Zidovudine; Zimbabwe | 2006 |
A double-blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; China; DNA, Viral; Double-Blind Method; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2006 |
Pharmacokinetics of telbivudine in healthy subjects and absence of drug interaction with lamivudine or adefovir dipivoxil.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Antiviral Agents; Area Under Curve; Drug Interactions; Drug Therapy, Combination; Female; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine | 2006 |
Overlap lamivudine treatment in patients with chronic hepatitis B receiving adefovir for lamivudine-resistant viral mutants.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load | 2006 |
Pharmacokinetics, safety and tolerance of single- and multiple-dose adefovir dipivoxil in healthy Chinese subjects.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Dose-Response Relationship, Drug; Female; Humans; Male; Organophosphonates | 2007 |
Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: impact on bone mineral density in HIV-infected children.
Topics: Adenine; Adolescent; Age Factors; Anti-Retroviral Agents; Bone Density; Bone Development; Child; Female; HIV Infections; Humans; Male; Organophosphonates; Salvage Therapy; Tenofovir | 2006 |
Resistance development over 144 weeks in treatment-naive patients receiving tenofovir disoproxil fumarate or stavudine with lamivudine and efavirenz in Study 903.
Topics: Adenine; Alkynes; Benzoxazines; Cyclopropanes; Double-Blind Method; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Treatment Outcome | 2006 |
Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection.
Topics: Adenine; Anti-HIV Agents; Chi-Square Distribution; DNA, Viral; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Statistics, Nonparametric; Tenofovir; Treatment Failure | 2006 |
Pharmacokinetics and dosing recommendations of tenofovir disoproxil fumarate in hepatic or renal impairment.
Topics: Adenine; Adult; Aged; Drug Administration Schedule; Drug Monitoring; Female; Humans; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Organophosphonates; Renal Dialysis; Renal Insufficiency; Reverse Transcriptase Inhibitors; Severity of Illness Index; Tenofovir | 2006 |
A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Biomarkers; Body Fat Distribution; Dideoxynucleosides; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lipids; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Zidovudine | 2006 |
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz versus fixed-dose zidovudine/lamivudine and efavirenz in antiretroviral-naive patients: virologic, immunologic, and morphologic changes--a 96-week analysis.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Genotype; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Oxazines; RNA, Viral; Tenofovir; Time Factors; Viral Load; Zidovudine | 2006 |
Virologic response of zidovudine, lamivudine, and tenofovir disoproxil fumarate combination in antiretroviral-naive HIV-1-infected patients.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects; Tenofovir; Viral Load; Zidovudine | 2006 |
Randomized controlled study of tenofovir and adefovir in chronic hepatitis B virus and HIV infection: ACTG A5127.
Topics: Adenine; Adult; Alanine Transaminase; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2006 |
Pharmacokinetics and safety of tenofovir disoproxil fumarate on coadministration with lopinavir/ritonavir.
Topics: Adenine; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Humans; Organophosphonates; Ritonavir; Saquinavir; Tenofovir | 2006 |
Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B for up to 5 years.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates | 2006 |
Effect of switching to tenofovir with emtricitabine in patients with chronic hepatitis B failing to respond to an adefovir-containing regimen.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2006 |
[A double-blind, randomized, lamivudine-controlled clinical trial of DAIDING (adefovir dipivoxil) for lamivudine-resistant patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Double-Blind Method; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2006 |
Renal function in patients receiving tenofovir with ritonavir/lopinavir or ritonavir/atazanavir in the HIV Outpatient Study (HOPS) cohort.
Topics: Adenine; Adult; Atazanavir Sulfate; Cohort Studies; Female; HIV Infections; Humans; Kidney; Lopinavir; Male; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Ritonavir; Tenofovir | 2006 |
Efficacy and safety of tenofovir double-dose in treatment-experienced HIV-infected patients: the TENOPLUS study.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation; Organophosphonates; Pilot Projects; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Viral Load | 2007 |
[A clinical study of adefovir dipivoxil, made in China, for treatment of hepatitis B e antigen-positive patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Double-Blind Method; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Middle Aged; Mutation; Organophosphonates; Young Adult | 2006 |
Efficacy of adefovir dipivoxil in the treatment of lamivudine-resistant hepatitis B virus genotype C infection.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2007 |
Adding-on versus switching-to adefovir therapy in lamivudine-resistant HBeAg-negative chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Salvage Therapy; Treatment Outcome; Virus Replication | 2007 |
Treatment of hepatitis B with lamivudine and tenofovir in HIV/HBV-coinfected patients: factors associated with response.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Load | 2007 |
Virological response and incidence of adefovir resistance in lamivudine-resistant patients treated with adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2006 |
Antiretroviral efficacy and virological profile of a zidovudine/lamivudine/tenofovir disoproxil fumarate combination therapy in antiretroviral-naive patients.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Mutation; Organophosphonates; Pilot Projects; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure; Treatment Outcome; Zidovudine | 2006 |
Low risk of hepatitis B virus recurrence after withdrawal of long-term hepatitis B immunoglobulin in patients receiving maintenance nucleos(t)ide analogue therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Liver Transplantation; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Risk Factors; Secondary Prevention; Treatment Outcome | 2007 |
Efficacy and safety of adefovir dipivoxil 20 mg daily in HBeAg-positive patients with lamivudine-resistant hepatitis B virus and a suboptimal virological response to adefovir dipivoxil 10 mg daily.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2007 |
Adefovir dipivoxil for wait-listed and post-liver transplantation patients with lamivudine-resistant hepatitis B: final long-term results.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Kidney Diseases; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Secondary Prevention; Waiting Lists | 2007 |
Hepatitis B virus resistance to adefovir in a nucleotide naive patient with chronic hepatitis B virus infection.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Mutation; Organophosphonates; Virus Replication | 2007 |
Metabolic and anthropometric changes one year after switching from didanosine/stavudine to tenofovir in HIV-infected patients.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Body Weight; CD4 Lymphocyte Count; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Didanosine; Female; Glomerular Filtration Rate; Glycated Hemoglobin; Hemoglobins; HIV Infections; Humans; Lactic Acid; Male; Middle Aged; Organophosphonates; Phosphates; Skinfold Thickness; Stavudine; Tenofovir; Treatment Outcome; Triglycerides; Uric Acid; Viral Load | 2007 |
No change in calculated creatinine clearance after tenofovir initiation among Thai patients.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Antiviral Agents; Body Weight; Creatinine; Female; HIV Infections; Humans; Kidney; Kidney Function Tests; Lamivudine; Male; Organophosphonates; Tenofovir; Thailand | 2007 |
Adefovir dipivoxil treatment of lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antibodies, Viral; Antiviral Agents; Bilirubin; Creatinine; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome; Viral Load | 2007 |
Pharmacokinetics of emtricitabine, tenofovir, and GS-9137 following coadministration of emtricitabine/tenofovir disoproxil fumarate and ritonavir-boosted GS-9137.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Antiviral Agents; Cross-Over Studies; Deoxycytidine; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Emtricitabine; Female; Humans; Male; Middle Aged; Organophosphonates; Quinolones; Ritonavir; Tenofovir | 2007 |
Intensification of a triple-nucleoside regimen with tenofovir or efavirenz in HIV-1-infected patients with virological suppression.
Topics: Adenine; Adult; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Patient Compliance; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2007 |
Adefovir dipivoxil alone or in combination with lamivudine for three months in patients with lamivudine resistant compensated chronic hepatitis B.
Topics: Adenine; Adult; Aged; Alanine Transaminase; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Retrospective Studies; Reverse Transcriptase Inhibitors; Treatment Outcome | 2007 |
Molecular basis of antagonism between K70E and K65R tenofovir-associated mutations in HIV-1 reverse transcriptase.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Computer Simulation; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutagenesis, Site-Directed; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Renal function in antiretroviral-experienced patients treated with tenofovir disoproxil fumarate associated with atazanavir/ritonavir.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Creatinine; Female; France; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Diseases; Male; Middle Aged; Models, Biological; Oligopeptides; Organophosphonates; Prognosis; Prospective Studies; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome | 2007 |
Steady-state pharmacokinetics of emtricitabine and tenofovir disoproxil fumarate administered alone and in combination in healthy volunteers.
Topics: Adenine; Adult; Anti-Retroviral Agents; Area Under Curve; Cross-Over Studies; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Humans; Male; Organophosphonates; Tenofovir | 2007 |
[Three year adefovir dipivoxil treatment for hepatitis B e antigen-positive chronic hepatitis B patients].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Young Adult | 2007 |
Fosamprenavir/ritonavir plus tenofovir does not affect amprenavir pharmacokinetics: no effect of tenofovir.
Topics: Adenine; Anti-Retroviral Agents; Area Under Curve; Carbamates; Cross-Over Studies; Drug Administration Schedule; Drug Therapy, Combination; Furans; HIV Protease Inhibitors; HIV Seronegativity; Humans; Male; Organophosphates; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides; Tenofovir | 2007 |
Normalization of fat accrual in lipoatrophic, HIV-infected children switched from stavudine to tenofovir and from protease inhibitor to efavirenz.
Topics: Absorptiometry, Photon; Adenine; Adolescent; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atrophy; Benzoxazines; Body Composition; CD4 Lymphocyte Count; Child; Child, Preschool; Cyclopropanes; Female; HIV Protease Inhibitors; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Italy; Male; Organophosphonates; Prospective Studies; Protease Inhibitors; Stavudine; Tenofovir; Time Factors; Treatment Outcome; Viral Load | 2007 |
The impact of reducing stavudine dose versus switching to tenofovir on plasma lipids, body composition and mitochondrial function in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Body Composition; Cholesterol; Drug Administration Schedule; Female; HIV; HIV Infections; Humans; Leukocytes, Mononuclear; Lipodystrophy; Male; Middle Aged; Mitochondria; Organophosphonates; Oxygen Consumption; Stavudine; Tenofovir; Treatment Outcome; Triglycerides | 2007 |
The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients.
Topics: Adenine; Administration, Oral; Adult; Antiretroviral Therapy, Highly Active; Case-Control Studies; Drug Interactions; Female; Genotype; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Lopinavir; Male; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome | 2008 |
Pharmacokinetic interaction between TMC114/ritonavir and tenofovir disoproxil fumarate in healthy volunteers.
Topics: Adenine; Adolescent; Adult; Anti-Retroviral Agents; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Male; Middle Aged; Organophosphonates; Ritonavir; Tenofovir; Treatment Outcome | 2007 |
Lopinavir/Ritonavir pharmacokinetic profile: impact of sex and other covariates following a change from twice-daily to once-daily therapy.
Topics: Adenine; Adult; Area Under Curve; Capsules; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Sex Factors; Tenofovir | 2007 |
Compromised immunologic recovery in patients receiving tipranavir/ritonavir coadministered with tenofovir and didanosine in Randomized Evaluation of Strategic Intervention in multidrug-resiStant patients with tipranavir (RESIST) studies.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Didanosine; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Pyridines; Pyrones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Sulfonamides; Tenofovir; Treatment Outcome; Viral Load | 2007 |
[A clinical study of adefovir dipivoxil in treating lamivudine refractory HBeAg-positive chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2007 |
Renal safety of tenofovir in HIV-infected children: a prospective, 96-week longitudinal study.
Topics: Adenine; Adolescent; Anti-HIV Agents; Child; Child, Preschool; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Male; Organophosphonates; Prospective Studies; Tenofovir | 2007 |
Tenofovir comedication does not impair the steady-state pharmacokinetics of ritonavir-boosted atazanavir in HIV-1-infected adults.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Area Under Curve; Atazanavir Sulfate; Chromatography, Liquid; Drug Combinations; Drug Interactions; Drug Monitoring; Female; Half-Life; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Matched-Pair Analysis; Metabolic Clearance Rate; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tandem Mass Spectrometry; Tenofovir; Time Factors; Treatment Outcome | 2007 |
Bioequivalence of efavirenz/emtricitabine/tenofovir disoproxil fumarate single-tablet regimen.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Alkynes; Benzoxazines; Cross-Over Studies; Cyclopropanes; Deoxycytidine; Emtricitabine; Fasting; Female; Humans; Male; Middle Aged; Organophosphonates; Tablets; Tenofovir; Therapeutic Equivalency | 2007 |
Low-level K65R mutation in HIV-1 reverse transcriptase of treatment-experienced patients exposed to abacavir or didanosine.
Topics: Adenine; Alleles; Didanosine; Dideoxynucleosides; Double-Blind Method; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Organophosphonates; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2007 |
Pregnancy prevention practices among women with multiple partners in an HIV prevention trial.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Condoms; Contraception; Contraception Behavior; Contraceptive Agents, Female; Female; Health Behavior; HIV Infections; Humans; Interviews as Topic; Organophosphonates; Pregnancy; Sex Work; Tenofovir | 2007 |
Absence of a pharmacokinetic interaction between entecavir and adefovir.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Area Under Curve; Cross-Over Studies; Drug Interactions; Female; Guanine; Humans; Male; Organophosphonates | 2007 |
Determinants of high-risk sexual behavior during post-exposure prophylaxis to prevent HIV infection.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Interviews as Topic; Lamivudine; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Risk-Taking; Sexual Partners; Surveys and Questionnaires; Tenofovir; Treatment Outcome | 2008 |
Low-dose tenofovir is more potent than adefovir and is effective in controlling HBV viremia in chronic HBeAg-negative hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Viremia | 2007 |
Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B Antibodies; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Humans; Immunity, Cellular; Kinetics; Male; Middle Aged; Models, Immunological; Organophosphonates; T-Lymphocytes; Treatment Outcome; Viral Load; Viremia; Virus Replication | 2007 |
Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study.
Topics: Adenine; Adolescent; Adult; Aged; Australia; Canada; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Integrase Inhibitors; HIV-1; Humans; Lamivudine; Latin America; Male; Middle Aged; Organic Chemicals; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; RNA, Viral; Tenofovir; Thailand; Time Factors; Treatment Outcome; United States | 2007 |
Acceptability of tenofovir gel as a vaginal microbicide by US male participants in a Phase I clinical trial (HPTN 050).
Topics: Adenine; Administration, Intravaginal; Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Patient Satisfaction; Sexually Transmitted Diseases; Tenofovir; Treatment Outcome; Vaginal Creams, Foams, and Jellies | 2007 |
Second tenofovir phase III study for the chronic HBV reaches primary endpoint.
Topics: Adenine; Anti-HIV Agents; Double-Blind Method; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2007 |
Treatment of hepatitis B e antigen positive chronic hepatitis with telbivudine or adefovir: a randomized trial.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine; Viral Load | 2007 |
Cost effectiveness of entecavir versus lamivudine with adefovir salvage in HBeAg-positive chronic hepatitis B.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Cohort Studies; Cost-Benefit Analysis; Disease Progression; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Markov Chains; Organophosphonates; Quality of Life; Salvage Therapy | 2007 |
Tenofovir disoproxil fumarate, emtricitabine, and efavirenz compared with zidovudine/lamivudine and efavirenz in treatment-naive patients: 144-week analysis.
Topics: Adenine; Adult; Alkynes; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2008 |
[Diammonium glycyrrhizinate does not affect efficacy of adefovir dipivoxil therapy in patients with HBeAg-positive chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Double-Blind Method; Glycyrrhizic Acid; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Treatment Outcome | 2007 |
[Efficacy of adefovir dipivoxil was not related to genotypes B and C of hepatitis B virus: a randomized, double-blind, multicenter clinical study].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Genotype; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2007 |
Clinical trial: effects of adefovir dipivoxil therapy in Asian and Caucasian patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Double-Blind Method; Drug Administration Schedule; Female; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Placebos; Regression Analysis; Treatment Outcome; White People | 2007 |
Low resistance to adefovir combined with lamivudine: a 3-year study of 145 lamivudine-resistant hepatitis B patients.
Topics: Adenine; Adult; Aged; Antiviral Agents; Disease Progression; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Risk Factors; Survival Analysis; Treatment Outcome | 2007 |
Hepatitis B virus e antigen loss during adefovir dipivoxil therapy is associated with enhanced virus-specific CD4+ T-cell reactivity.
Topics: Adenine; Adult; Antiviral Agents; CD4-Positive T-Lymphocytes; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lymphocyte Activation; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome; Virus Replication | 2008 |
[Adefovir dipivoxil compassionate use program in Spain: efficacy and resistance analysis].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Spain | 2007 |
Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Nevirapine; Organophosphonates; Pregnancy; Reverse Transcriptase Inhibitors; Tenofovir; Zambia | 2007 |
Observational study on HIV-infected subjects failing HAART receiving tenofovir plus didanosine as NRTI backbone.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Didanosine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Tenofovir; Treatment Outcome | 2007 |
[A clinical study of adefovir dipivoxil treatment for chronic hepatitis patients with cirrhosis in their decompensation period].
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates | 2007 |
Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Administration Schedule; Drug Therapy, Combination; HIV; HIV Infections; HIV Integrase Inhibitors; Humans; Lamivudine; Linear Models; Organic Chemicals; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; RNA, Viral; Statistics, Nonparametric; Tenofovir; Time Factors; Viral Load; Virus Integration; Virus Latency; Virus Replication | 2007 |
Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection.
Topics: Adenine; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Deoxycytidine; Drug Administration Schedule; Emtricitabine; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Male; Organophosphonates; Tenofovir; Thailand; Transaminases; Treatment Outcome; Viral Load | 2008 |
Effects of the change from Stavudine to tenofovir in human immunodeficiency virus-infected children treated with highly active antiretroviral therapy: studies on mitochondrial toxicity and thymic function.
Topics: Adenine; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Glucose; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Child; DNA, Mitochondrial; Female; HIV Infections; Humans; Lipids; Male; Mitochondria; Organophosphonates; Stavudine; Tenofovir; Thymus Gland; Viral Load | 2008 |
Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy.
Topics: Adenine; Adult; Drug Therapy, Combination; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Diseases; Kidney Tubules; Male; Middle Aged; Nucleosides; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Time | 2008 |
The pharmacokinetics and viral activity of tenofovir in the male genital tract.
Topics: Adenine; Adult; Anti-HIV Agents; Chromatography, High Pressure Liquid; Genitalia, Male; HIV-1; Humans; Male; Middle Aged; Organophosphonates; RNA, Viral; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Tenofovir | 2008 |
Tenofovir monotherapy is effective in hepatitis B patients with antiviral treatment failure to adefovir in the absence of adefovir-resistant mutations.
Topics: Adenine; Adult; Aged; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure; Viral Load | 2008 |
96 weeks combination of adefovir dipivoxil plus emtricitabine vs. adefovir dipivoxil monotherapy in the treatment of chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates | 2008 |
The pharmacokinetics and safety of adefovir dipivoxil in children and adolescents with chronic hepatitis B virus infection.
Topics: Adenine; Adolescent; Antiviral Agents; Area Under Curve; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; Half-Life; Hepatitis B, Chronic; Humans; Male; Organophosphonates | 2008 |
Plasma HIV load and proviral DNA decreases after two standard antiretroviral regimens in HIV-positive patients naïve to antiretrovirals.
Topics: Adenine; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Biomarkers; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cyclopropanes; DNA, Viral; Drug Administration Schedule; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2008 |
Recent availability of two novel, fixed formulations of antiretroviral nucleoside analogues: a 12-month prospective, open-label survey of their practical use and therapeutic perspectives in antiretroviral-naive and -experienced patients.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2008 |
Acceptability of tenofovir gel as a vaginal microbicide among women in a phase I trial: a mixed-methods study.
Topics: Adenine; Administration, Intravaginal; Adult; Anti-Infective Agents, Local; Cohort Studies; Female; HIV Infections; Humans; Middle Aged; Organophosphonates; Patient Acceptance of Health Care; Patient Satisfaction; Tenofovir; Treatment Outcome; Vaginal Creams, Foams, and Jellies | 2008 |
Lamivudine compared with lamivudine and adefovir dipivoxil for the treatment of HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates | 2008 |
The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Anti-Infective Agents; CCR5 Receptor Antagonists; Cyclohexanes; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Maraviroc; Middle Aged; Organophosphonates; Receptors, CCR5; Statistics as Topic; Tenofovir; Triazoles; Trimethoprim, Sulfamethoxazole Drug Combination | 2008 |
Changes in metabolic toxicity after switching from stavudine/didanosine to tenofovir/lamivudine--a Staccato trial substudy.
Topics: Absorptiometry, Photon; Adenine; Adult; Anti-HIV Agents; Body Fat Distribution; Didanosine; DNA, Mitochondrial; HIV Infections; Humans; Lamivudine; Lipids; Liver Function Tests; Organophosphonates; Ritonavir; RNA, Viral; Saquinavir; Stavudine; Tenofovir; Thailand | 2008 |
Short-term overlap lamivudine treatment with adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2008 |
Sequential combination therapy leads to biochemical and histological improvement despite low ongoing intrahepatic hepatitis B virus replication.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Female; Genotype; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Interferon alpha-2; Interferon-alpha; Liver; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Virus Replication | 2008 |
Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients.
Topics: Adenine; Adult; Female; Gene Frequency; Genotype; HIV Infections; Humans; Kidney; Male; Membrane Transport Proteins; Metabolic Clearance Rate; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Polymorphism, Single Nucleotide; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
An open-label pilot study to determine the efficacy of lopinavir/ritonavir and tenofovir DF in the treatment of HIV-infected patients experiencing first virologic failure on a non-nucleoside-based regimen.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lopinavir; Middle Aged; Organophosphonates; Pilot Projects; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome | 2008 |
Hepatocellular carcinoma is associated with an increased risk of hepatitis B virus recurrence after liver transplantation.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Circular; DNA, Viral; Female; Follow-Up Studies; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Immunohistochemistry; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Risk Assessment; Risk Factors; Secondary Prevention; Sequence Analysis, DNA; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2008 |
Safety, efficacy, and pharmacokinetics of adefovir dipivoxil in children and adolescents (age 2 to <18 years) with chronic hepatitis B.
Topics: Adenine; Adolescent; Age Factors; Alanine Transaminase; Antiviral Agents; Child; Child, Preschool; DNA, Viral; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Male; Organophosphonates; Treatment Outcome | 2008 |
Risk of early virological failure of once-daily tenofovir-emtricitabine plus twice-daily nevirapine in antiretroviral therapy-naive HIV-infected patients.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Atazanavir Sulfate; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Male; Middle Aged; Nevirapine; Oligopeptides; Organophosphonates; Pyridines; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2008 |
Dynamics of lamivudine-resistant hepatitis B virus during adefovir monotherapy versus lamivudine plus adefovir combination therapy.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Polymorphism, Single Nucleotide; Reverse Transcriptase Inhibitors | 2008 |
[Adefovir dipivoxil treatment of hepatic cirrhosis complicated with hepatitis B virus associated glomerulonephritis].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Female; Glomerulonephritis; Hepatitis B; Hepatitis B virus; Humans; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Young Adult | 2008 |
Addition of single-dose tenofovir and emtricitabine to intrapartum nevirapine to reduce perinatal HIV transmission.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Nevirapine; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir | 2008 |
Evidence of long-term suppression of hepatitis B virus DNA by tenofovir as rescue treatment in patients coinfected by HIV.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Time Factors; Treatment Outcome; Virus Replication | 2008 |
Suboptimal response to adefovir dipivoxil therapy for chronic hepatitis B in nucleoside-naive patients is not due to pre-existing drug-resistant mutants.
Topics: Adenine; Adolescent; Adult; Cell Line, Tumor; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Europe; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Patient Compliance; Phenotype; Reverse Transcriptase Inhibitors; Time Factors; Treatment Failure; United States; Viral Load; Virus Replication | 2008 |
[Lamivudine and adefovir dipivoxil combination treatment for liver cirrhosis patients with CHB].
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates | 2008 |
Lack of a significant drug interaction between raltegravir and tenofovir.
Topics: Adenine; Adolescent; Adult; Aged; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Integrase Inhibitors; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2008 |
Zidovudine/lamivudine/abacavir plus tenofovir in HIV-infected naive patients: a 96-week prospective one-arm pilot study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Endpoint Determination; Female; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects; Prospective Studies; Spain; Tenofovir; Treatment Outcome; Viral Load; Zidovudine | 2008 |
Endothelial function in human immunodeficiency virus-infected antiretroviral-naive subjects before and after starting potent antiretroviral therapy: The ACTG (AIDS Clinical Trials Group) Study 5152s.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Brachial Artery; CD4 Lymphocyte Count; Cyclopropanes; Endothelium, Vascular; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Prospective Studies; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Tenofovir; Time Factors; Zidovudine | 2008 |
A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naïve individuals in Thailand.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; DNA, Viral; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Thailand; Treatment Outcome; Zidovudine | 2008 |
Long-term efficacy and safety of adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2008 |
Comparison of the antiviral activity of adefovir and tenofovir on hepatitis B virus in HIV-HBV-coinfected patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Tenofovir; Treatment Outcome; Viral Load | 2008 |
The 3-year renal safety of a tenofovir disoproxil fumarate vs. a thymidine analogue-containing regimen in antiretroviral-naive patients.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Creatinine; Double-Blind Method; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Phosphorus; Proteinuria; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Young Adult; Zidovudine | 2008 |
Efficacy of pegylated interferon plus ribavirin treatment in HIV/hepatitis C virus co-infected patients receiving abacavir plus lamivudine or tenofovir plus either lamivudine or emtricitabine as nucleoside analogue backbone.
Topics: Adenine; Adult; Anti-HIV Agents; Blood; Cohort Studies; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Female; Follow-Up Studies; Hepacivirus; Hepatitis C, Chronic; HIV Infections; HIV-1; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Tenofovir; Treatment Outcome; Viral Load | 2008 |
Effectiveness and safety of generic fixed-dose combination of tenofovir/emtricitabine/efavirenz in HIV-1-infected patients in Western India.
Topics: Adenine; Adolescent; Adult; Aged; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Drugs, Generic; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Immunosuppression Therapy; India; Male; Middle Aged; Organophosphonates; Prevalence; Tenofovir; Treatment Outcome; Young Adult | 2008 |
A randomized study of adefovir dipivoxil in place of HBIG in combination with lamivudine as post-liver transplantation hepatitis B prophylaxis.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Hepatitis B; Humans; Immunization, Passive; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Patient Selection; Postoperative Complications; Viral Load | 2008 |
Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109).
Topics: Adenine; Female; HIV Infections; HIV-1; Humans; Infant, Newborn; Maternal-Fetal Exchange; Organophosphonates; Population Groups; Pregnancy; Pregnancy Complications, Infectious; Prenatal Exposure Delayed Effects; Tenofovir | 2009 |
High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients.
Topics: Adenine; Adult; Amino Acid Substitution; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Nevirapine; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load; Viral Proteins | 2009 |
[Two novel fixed formulations of nucleoside analogues (tenofovir-emtricitabine, and abacavir-lamivudine). Prospective, open study on clinical practice and therapeutic perspectives, in patients naïve and in subjects pre-treated with antiretrovirals].
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Efficacy and safety of adefovir dipivoxil plus pegylated interferon-alpha2a for the treatment of lamivudine-resistant hepatitis B virus infection in HIV-infected patients.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reverse Transcriptase Inhibitors; Treatment Outcome | 2008 |
Pharmacokinetics of emtricitabine/tenofovir disoproxil fumarate and tacrolimus at steady state when administered alone or in combination.
Topics: Adenine; Adult; Area Under Curve; Deoxycytidine; Dose-Response Relationship, Drug; Drug Interactions; Emtricitabine; Female; Flatulence; Half-Life; Humans; Immunosuppressive Agents; Male; Middle Aged; Nervous System Diseases; Organophosphonates; Patient Dropouts; Tacrolimus; Tenofovir; Time Factors; Young Adult | 2008 |
Changes in sexual risk behavior among participants in a PrEP HIV prevention trial.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Counseling; Double-Blind Method; Female; Ghana; HIV Infections; Humans; Interviews as Topic; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Reduction Behavior; Risk-Taking; Sexual Behavior; Sexual Partners; Surveys and Questionnaires; Tenofovir; Treatment Outcome; Unsafe Sex; Young Adult | 2008 |
Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Load | 2008 |
Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Viral Load | 2009 |
Complex dynamics of hepatitis B virus resistance to adefovir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction; Virus Replication | 2009 |
Failure of adefovir 20 mg to improve suboptimal response in lamivudine-resistant hepatitis B patients treated with adefovir 10 mg and lamivudine.
Topics: Adenine; Antiviral Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Treatment Outcome | 2008 |
Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: similar effectiveness of lamivudine, tenofovir, or combination therapy.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biopsy; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; HIV Infections; HIV-1; Humans; Immunosuppression Therapy; Lamivudine; Liver; Male; Middle Aged; Models, Biological; Organophosphonates; Prospective Studies; Tenofovir; Viral Load; Young Adult | 2009 |
Impact of adefovir dipivoxil on liver fibrosis and activity assessed with biochemical markers (FibroTest-ActiTest) in patients infected by hepatitis B virus.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Biopsy; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reagent Kits, Diagnostic; Treatment Outcome | 2009 |
Assessment of the steady-state pharmacokinetic interaction between etravirine administered as two different formulations and tenofovir disoproxil fumarate in healthy volunteers.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Belgium; Cross-Over Studies; Drug Interactions; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Netherlands; Nitriles; Organophosphonates; Pyridazines; Pyrimidines; Tenofovir; Young Adult | 2009 |
Tenofovir use in human immunodeficiency virus-1-infected children in the United kingdom and Ireland.
Topics: Adenine; Adolescent; Anti-HIV Agents; Child; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; Humans; Ireland; Male; Organophosphonates; Pediatrics; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; United Kingdom | 2009 |
Rapid and specific liquid chromatographic tandem mass spectrometric determination of tenofovir in human plasma and its fragmentation study.
Topics: Adenine; Adult; Chromatography, High Pressure Liquid; Humans; Organophosphonates; Reproducibility of Results; Tandem Mass Spectrometry; Tenofovir; Therapeutic Equivalency | 2009 |
Abacavir/3TC vs. tenofovir/FTC: interim results from ACTG 5202.
Topics: Adenine; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Pilot pharmacokinetic study of human immunodeficiency virus-infected patients receiving tenofovir disoproxil fumarate (TDF): investigation of systemic and intracellular interactions between TDF and abacavir, lamivudine, or lopinavir-ritonavir.
Topics: Adenine; Adult; Anti-HIV Agents; Area Under Curve; Cross-Sectional Studies; Dideoxynucleosides; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Longitudinal Studies; Lopinavir; Male; Middle Aged; Organophosphonates; Pilot Projects; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome | 2009 |
Tolerance and viral resistance after single-dose nevirapine with tenofovir and emtricitabine to prevent vertical transmission of HIV-1.
Topics: Adenine; Adult; Anti-HIV Agents; Cambodia; Cote d'Ivoire; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; Genotype; HIV Infections; HIV-1; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Nevirapine; Organophosphonates; Pregnancy; RNA, Viral; South Africa; Tenofovir; Viral Load | 2009 |
Mutations associated with the therapeutic efficacy of adefovir dipivoxil added to lamivudine in patients resistant to lamivudine with type B chronic hepatitis.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Treatment Outcome | 2009 |
[A study on the treatment of chronic hepatitis B with YMDD mutation].
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Young Adult | 2009 |
Simplification of antiretroviral therapy to a single-tablet regimen consisting of efavirenz, emtricitabine, and tenofovir disoproxil fumarate versus unmodified antiretroviral therapy in virologically suppressed HIV-1-infected patients.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Patient Compliance; Tenofovir | 2009 |
A simplification trial switching from nucleoside reverse transcriptase inhibitors to once-daily fixed-dose abacavir/lamivudine or tenofovir/emtricitabine in HIV-1-infected patients with virological suppression.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Spain; Tenofovir; Treatment Failure; Treatment Outcome | 2009 |
A randomized trial of two-drug versus three-drug tenofovir-containing maintenance regimens in virologically controlled HIV-1 patients.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Female; France; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load | 2009 |
Safety evaluation of 1% tenofovir gel in healthy men.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Cellulose; Circumcision, Male; Gels; Glycerol; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Penis; Phosphates; Propylene Glycols; Reverse Transcriptase Inhibitors; Single-Blind Method; Tenofovir; Treatment Outcome; Young Adult | 2009 |
Pharmacokinetics of tacrolimus co-administered with adefovir dipivoxil to liver transplant recipients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Hepatitis B; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Organophosphonates; Tacrolimus; Young Adult | 2009 |
Improvements in cheek volume in lipoatrophic individuals switching away from thymidine nucleoside reverse transcriptase inhibitors.
Topics: Absorptiometry, Photon; Adenine; Adult; Aged; Body Composition; Cheek; Dideoxynucleosides; Female; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Male; Middle Aged; Organophosphonates; Quality of Life; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Zidovudine | 2009 |
Switch from a ZDV/3TC-based regimen to a completely once daily (QD) regimen of emtricitabine/tenofovir DF fixed dose combination plus a third QD agent (SONETT).
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Emtricitabine; Female; Hemoglobins; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load; Young Adult; Zidovudine | 2009 |
Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cardiovascular Diseases; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Double-Blind Method; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Pyrimidinones; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome | 2009 |
A randomized comparative trial of continued zidovudine/lamivudine or replacement with tenofovir disoproxil fumarate/emtricitabine in efavirenz-treated HIV-1-infected individuals.
Topics: Adenine; Adipose Tissue; Adult; Aged; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Emtricitabine; Extremities; Female; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Lamivudine; Lipids; Male; Middle Aged; Organophosphonates; Tenofovir; Young Adult; Zidovudine | 2009 |
Modulation of K65R selection by zidovudine inclusion: analysis of HIV resistance selection in subjects with virologic failure receiving once-daily abacavir/lamivudine/zidovudine and tenofovir DF (study COL40263).
Topics: Adenine; Adult; Amino Acid Substitution; Anti-HIV Agents; Dideoxynucleosides; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects; RNA, Viral; Tenofovir; Treatment Failure; Zidovudine | 2009 |
Adefovir dipivoxil resistance patterns in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Cell Line; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; RNA-Directed DNA Polymerase | 2009 |
Modified directly observed antiretroviral therapy compared with self-administered therapy in treatment-naive HIV-1-infected patients: a randomized trial.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Aged; Anti-HIV Agents; Deoxycytidine; Dose-Response Relationship, Drug; Emtricitabine; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrimidinones; Retrospective Studies; RNA, Viral; Stavudine; Tenofovir; Treatment Outcome; Young Adult | 2009 |
Covert use, vaginal lubrication, and sexual pleasure: a qualitative study of urban U.S. Women in a vaginal microbicide clinical trial.
Topics: Adenine; Administration, Intravaginal; Adult; Anti-HIV Agents; Anti-Infective Agents, Local; Black or African American; Cohort Studies; Coitus; Female; Heterosexuality; HIV Infections; Humans; Interpersonal Relations; Interviews as Topic; Lubricants; Male; Organophosphonates; Patient Satisfaction; Pleasure; Sexual Behavior; Sexual Partners; Tenofovir; United States; Urban Population; Vagina; Vaginal Creams, Foams, and Jellies | 2010 |
Efficacy of entecavir in patients with chronic hepatitis B resistant to both lamivudine and adefovir or to lamivudine alone.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Treatment Outcome | 2009 |
Lack of effect of tenofovir disoproxil fumarate on pharmacokinetics of hormonal contraceptives.
Topics: Adenine; Adult; Anti-HIV Agents; Contraceptives, Oral, Synthetic; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Humans; Middle Aged; Norgestrel; Organophosphonates; Tenofovir | 2009 |
Development of HIV-1 drug resistance through 144 weeks in antiretroviral-naïve subjects on emtricitabine, tenofovir disoproxil fumarate, and efavirenz compared with lamivudine/zidovudine and efavirenz in study GS-01-934.
Topics: Adenine; Alkynes; Amino Acid Substitution; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Genome, Viral; Genotype; HIV Infections; HIV-1; Humans; Lamivudine; Mutation, Missense; Organophosphonates; Tenofovir; Treatment Failure; Zidovudine | 2009 |
Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial.
Topics: Adenine; Adult; Alkynes; Analysis of Variance; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Prognosis; Pyrrolidinones; Raltegravir Potassium; RNA, Viral; Safety; Tenofovir; Treatment Outcome; Viral Load | 2009 |
Raltegravir as effective as efavirenz in 144-week data.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Double-Blind Method; Drug Therapy, Combination; HIV Infections; HIV Integrase Inhibitors; HIV-1; Humans; Lamivudine; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Treatment Outcome | 2009 |
Rescue monotherapy in lamivudine-resistant hepatitis B e antigen-positive chronic hepatitis B: adefovir versus entecavir.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Salvage Therapy; Treatment Outcome; Young Adult | 2009 |
Phase I trials of amonafide as monotherapy and in combination with cytarabine in patients with poor-risk acute myeloid leukemia.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthalimides; Organophosphonates; Remission Induction; Risk Factors; Treatment Outcome; Young Adult | 2010 |
Adefovir plus lamivudine are more effective than adefovir alone in lamivudine-resistant HBeAg- chronic hepatitis B patients: a 4-year study.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2010 |
[Efficacy and safety of TAM-sparing antiretroviral regimens in naïve HIV-positive patients].
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Hyperinsulinism; Hyperlipidemias; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Prospective Studies; Tenofovir; Thymidine; Treatment Outcome; Young Adult | 2009 |
Simplification of antiretroviral therapy with tenofovir-emtricitabine or abacavir-Lamivudine: a randomized, 96-week trial.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Emtricitabine; Female; HIV Infections; HLA-B Antigens; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load | 2009 |
Modified directly observed therapy to improve HIV treatment outcomes: little impact with potent, once-daily therapy in unselected antiretroviral-naïve patients.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Directly Observed Therapy; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Lopinavir; Medication Adherence; Organophosphonates; Pyrimidinones; Ritonavir; Self Administration; Stavudine; Tenofovir; Treatment Outcome | 2009 |
Steady-state amprenavir and tenofovir pharmacokinetics after coadministration of unboosted or ritonavir-boosted fosamprenavir with tenofovir disoproxil fumarate in healthy volunteers.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Carbamates; Cross-Over Studies; Drug Administration Schedule; Drug Eruptions; Drug Interactions; Drug Therapy, Combination; Female; Furans; HIV Infections; Humans; Male; Middle Aged; Organophosphates; Organophosphonates; Prodrugs; Ritonavir; Sulfonamides; Tenofovir; Young Adult | 2010 |
Intrapartum tenofovir and emtricitabine reduces low-concentration drug resistance selected by single-dose nevirapine for perinatal HIV prevention.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Infectious Disease Transmission, Vertical; Mutation; Nevirapine; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2009 |
[A clinical study of adefovir dipivoxil treatment for chronic hepatitis patients with cirrhosis in their decompensation period].
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Collagen; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome | 2009 |
Rates of virological failure in patients treated in a home-based versus a facility-based HIV-care model in Jinja, southeast Uganda: a cluster-randomised equivalence trial.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Community Health Services; Female; HIV; HIV Infections; Home Care Services; Humans; Lamivudine; Male; Nevirapine; Organophosphonates; Stavudine; Tenofovir; Uganda; Zidovudine | 2009 |
Abacavir-lamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy.
Topics: Adenine; Adolescent; Adult; Analysis of Variance; Anti-HIV Agents; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Double-Blind Method; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Female; Fractures, Bone; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; RNA, Viral; Tenofovir; Therapeutic Equivalency; Time Factors; Treatment Failure; Viral Load; Young Adult | 2009 |
Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial.
Topics: Adenine; Adolescent; Adult; Africa; Aged; Anemia; Anti-Retroviral Agents; CD4 Lymphocyte Count; Creatinine; Dideoxynucleosides; Disease Progression; Drug Monitoring; Female; Glomerular Filtration Rate; Hemoglobins; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Lamivudine; Male; Middle Aged; Neutropenia; Neutrophils; Nevirapine; Organophosphonates; RNA, Viral; Tenofovir; Urea; Viral Load; Zidovudine | 2010 |
Abacavir-based therapy does not affect biological mechanisms associated with cardiovascular dysfunction.
Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; Cardiovascular Diseases; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lipids; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2010 |
Full-length hepatitis B virus sequences from naïve patients with fluctuation of viral load during ADV monotherapy.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; China; DNA, Viral; Female; Genome, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA; Sequence Deletion; Treatment Failure; Viral Load; Viral Proteins; Young Adult | 2010 |
Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months.
Topics: Adenine; Adipocytes; Adipose Tissue; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cell Differentiation; Cyclopropanes; Drug Therapy, Combination; Fatty Acids; Female; Gene Expression; Genes, Mitochondrial; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lamivudine; Male; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Up-Regulation; Zidovudine | 2009 |
A randomized controlled trial of pegylated interferon-alpha2a plus adefovir dipivoxil for hepatitis B e antigen-negative chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Young Adult | 2009 |
Once-daily atazanavir/ritonavir compared with twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 96-week efficacy and safety results of the CASTLE study.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lipids; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2010 |
Switching the nucleoside reverse transcriptase inhibitor backbone to tenofovir disoproxil fumarate + emtricitabine promptly improves triglycerides and low-density lipoprotein cholesterol in dyslipidaemic patients.
Topics: Adenine; Adult; Anti-HIV Agents; Cholesterol, LDL; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Middle Aged; Nucleosides; Organophosphonates; Tenofovir; Triglycerides | 2010 |
Abacavir and tenofovir disoproxil fumarate co-administration results in a nonadditive antiviral effect in HIV-1-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxyguanine Nucleotides; Dideoxynucleosides; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; RNA, Viral; Tenofovir; Treatment Outcome | 2010 |
[The analyse of effectiveness in HBeAg-positive chronic viral hepatitis B treated by adefovir dipivoxil combined with bicyclol].
Topics: Adenine; Adolescent; Adult; Aged; Biphenyl Compounds; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2009 |
[Comparison of efficacy between adefovir dipivoxil and entecavir in patients with chronic hepatitis B].
Topics: Adenine; Administration, Oral; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Polymerase Chain Reaction; Prospective Studies; Treatment Outcome; Virus Replication | 2010 |
Long-term efficacy and safety of once-daily nevirapine in combination with tenofovir and emtricitabine in the treatment of HIV-infected patients: a 72-week prospective multicenter study (TENOR-trial).
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nevirapine; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2009 |
Patient-reported outcomes in virologically suppressed, HIV-1-Infected subjects after switching to a simplified, single-tablet regimen of efavirenz, emtricitabine, and tenofovir DF.
Topics: Adenine; Adolescent; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Patient Compliance; Patient Preference; Puerto Rico; Quality of Life; Reverse Transcriptase Inhibitors; Severity of Illness Index; Tablets; Tenofovir; Treatment Outcome; United States; Young Adult | 2010 |
Mitochondrial changes during D-drug-containing once-daily therapy in HIV-positive treatment-naive patients.
Topics: Adenine; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cross-Sectional Studies; Cyclopropanes; Didanosine; Dideoxynucleosides; DNA, Mitochondrial; Drug Administration Schedule; Female; HIV; HIV Infections; Humans; Lamivudine; Male; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; RNA; RNA, Mitochondrial; Tenofovir | 2010 |
Antiviral effect of entecavir in chronic hepatitis B: influence of prior exposure to nucleos(t)ide analogues.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Prospective Studies; Reverse Transcriptase Inhibitors; Virus Replication | 2010 |
Impact of low abundance HIV variants on response to ritonavir-boosted atazanavir or fosamprenavir given once daily with tenofovir/emtricitabine in antiretroviral-naive HIV-infected patients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Atazanavir Sulfate; Carbamates; Deoxycytidine; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Emtricitabine; Furans; Genetic Variation; HIV Infections; HIV-1; Humans; Middle Aged; Oligopeptides; Organophosphates; Organophosphonates; Pyridines; Ritonavir; RNA, Viral; Sequence Analysis, RNA; Sulfonamides; Tenofovir; Treatment Failure | 2010 |
The effects of a nucleoside-sparing antiretroviral regimen on the pharmacokinetics of ritonavir-boosted darunavir in HIV type-1-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Darunavir; Deoxycytidine; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides; Tenofovir; Treatment Outcome; Young Adult | 2010 |
The effect of tenofovir disoproxil fumarate on whole-body insulin sensitivity, lipids and adipokines in healthy volunteers.
Topics: Adenine; Adipokines; Adult; Anti-HIV Agents; Cholesterol; Cholesterol, LDL; Cross-Over Studies; Drug Administration Schedule; Glucose Clamp Technique; HIV Seronegativity; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Young Adult | 2010 |
Long-term adefovir dipivoxil monotherapy for up to 5 years in lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Korea; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome; Young Adult | 2010 |
Tenofovir/emtricitabine combination results in lower bone-mineral density.
Topics: Adenine; Anti-HIV Agents; Bone Density; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; HIV-1; Humans; Organophosphonates; Tenofovir; Treatment Outcome | 2010 |
Randomized comparison of renal effects, efficacy, and safety with once-daily abacavir/lamivudine versus tenofovir/emtricitabine, administered with efavirenz, in antiretroviral-naive, HIV-1-infected adults: 48-week results from the ASSERT study.
Topics: Adenine; Adolescent; Adult; Aged; Alkynes; Anti-HIV Agents; Benzoxazines; beta 2-Microglobulin; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Kidney; Lamivudine; Male; Middle Aged; Organophosphonates; Retinol-Binding Proteins; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2010 |
Gastrointestinal tolerability and quality of life in antiretroviral-naive HIV-1-infected patients: data from the CASTLE study.
Topics: Adenine; Adult; Aged; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Gastrointestinal Diseases; HIV Infections; HIV-1; Humans; Irritable Bowel Syndrome; Lopinavir; Male; Medication Adherence; Middle Aged; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Pyrimidinones; Quality of Life; Ritonavir; Surveys and Questionnaires; Tenofovir; Young Adult | 2010 |
Sequential therapy with adefovir dipivoxil and pegylated interferon alfa-2a for HBeAg-negative patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2011 |
A pilot study to determine the impact on dyslipidemia of adding tenofovir to stable background antiretroviral therapy: ACTG 5206.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cholesterol; Dyslipidemias; Epidemiologic Methods; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Pilot Projects; Tenofovir; Young Adult | 2010 |
Importance of serum concentration of adefovir for Lamivudine-adefovir combination therapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2010 |
[Comparison of the efficacy of 48 week-Entecavir therapy with that of Adefovir therapy for chronic hepatitis B patients].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2010 |
Overlap/switch to adefovir monotherapy for lamivudine-resistant patients who responded to combination therapy: a pilot controlled study.
Topics: Adenine; Adult; Aged; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects | 2010 |
Tenofovir is effective alone or with emtricitabine in adefovir-treated patients with chronic-hepatitis B virus infection.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Medication Adherence; Middle Aged; Mutation; Organophosphonates; Tenofovir | 2010 |
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of adefovir in human plasma and its application to a pharmacokinetic study.
Topics: Adenine; Administration, Oral; Antiviral Agents; Chromatography, Liquid; Drug Stability; Humans; Limit of Detection; Male; Organophosphonates; Pyrrolidonecarboxylic Acid; Quality Control; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry; Thiazolidines; Time Factors | 2010 |
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.
Topics: Adenine; Administration, Intravaginal; Adolescent; Adult; Anti-HIV Agents; Anti-Infective Agents, Local; Double-Blind Method; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Incidence; Organophosphonates; Patient Compliance; Pregnancy; Pregnancy Outcome; Rural Population; Sexual Behavior; South Africa; Tenofovir; Urban Population; Vaginal Creams, Foams, and Jellies; Viral Load; Young Adult | 2010 |
Question of ALT flare during switch to adefovir from lamivudine: A single center open-label, randomized, safety study (June 17, 2005 to February 5, 2009).
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Drug Substitution; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2010 |
Short communication: Comparable safety and efficacy with once-daily versus twice-daily dosing of lopinavir/ritonavir tablets with emtricitabine + tenofovir DF in antiretroviral-naïve, HIV type 1-infected subjects: 96 week final results of the randomized t
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Emtricitabine; HIV Infections; HIV-1; Humans; Lopinavir; Organophosphonates; Pyrimidinones; Ritonavir; Tenofovir | 2010 |
[Effect of adefovir and lamivudine combination therapy on lamivudine resistance chronic hepatitis B patients for 48 weeks].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2010 |
Pharmacokinetics and bioavailability of an integrase and novel pharmacoenhancer-containing single-tablet fixed-dose combination regimen for the treatment of HIV.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Biological Availability; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV Integrase; HIV Integrase Inhibitors; Humans; Male; Organophosphonates; Plasma; Quinolones; Tablets; Tenofovir | 2010 |
Pharmacokinetics of once-daily etravirine without and with once-daily darunavir/ritonavir in antiretroviral-naive HIV type-1-infected adults.
Topics: Adenine; Adult; Anti-HIV Agents; Darunavir; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Male; Nitriles; Organophosphonates; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides; Tenofovir; Treatment Outcome | 2010 |
[Efficacy and durability of generic adefovir dipivoxil in patients with HBeAg positive chronic hepatitis].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Double-Blind Method; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Treatment Outcome; Young Adult | 2009 |
[Add on lamivudine to adefovir monotherapy for the treatment of lamivudine-resistant chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2010 |
Long-term therapy with tenofovir is effective for patients co-infected with human immunodeficiency virus and hepatitis B virus.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; CD4 Lymphocyte Count; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Kaplan-Meier Estimate; Kidney; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Time Factors; Virus Replication | 2010 |
Maternal and nenonatal tenofovir and emtricitabine to prevent vertical transmission of HIV-1: tolerance and resistance.
Topics: Adenine; Adult; Antiviral Agents; Cambodia; Cote d'Ivoire; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Genotype; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Organophosphonates; Pregnancy; RNA, Viral; South Africa; Tenofovir; Viral Load | 2010 |
Comparison of changes in bone density and turnover with abacavir-lamivudine versus tenofovir-emtricitabine in HIV-infected adults: 48-week results from the ASSERT study.
Topics: Absorptiometry, Photon; Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Bone and Bones; Bone Density; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Europe; Female; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Young Adult | 2010 |
Efficacy of tenofovir disoproxil fumarate/emtricitabine compared with emtricitabine alone in antiretroviral-naive HIV-HBV coinfection in Thailand.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; Deoxycytidine; DNA, Viral; Emtricitabine; Female; Hepatitis B, Chronic; HIV Infections; Humans; Male; Organophosphonates; Prospective Studies; Tenofovir; Thailand | 2010 |
[Short-term efficacy of adefovir dipivoxil as an add-on therapy in the pegylated IFNalpha-2a treatment for HBeAg positive chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Young Adult | 2010 |
Efficacy of adefovir add-on lamivudine rescue therapy compared with switching to entecavir monotherapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2010 |
Selective determination of antiretroviral agents tenofovir, emtricitabine, and lamivudine in human plasma by a LC-MS-MS method for a bioequivalence study in healthy Indian subjects.
Topics: Adenine; Adult; Anti-Retroviral Agents; Chromatography, Liquid; Cross-Over Studies; Deoxycytidine; Drug Stability; Emtricitabine; Humans; India; Lamivudine; Least-Squares Analysis; Male; Middle Aged; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Tenofovir; Therapeutic Equivalency | 2010 |
Pharmacokinetics and pharmacodynamics of the non-nucleoside reverse-transcriptase inhibitor etravirine in treatment-experienced HIV-1-infected patients.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Aged; Darunavir; Double-Blind Method; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Middle Aged; Nitriles; Organophosphonates; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2010 |
Antiretroviral therapies in women after single-dose nevirapine exposure.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Retroviral Agents; CD4 Lymphocyte Count; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Infectious Disease Transmission, Vertical; Kaplan-Meier Estimate; Linear Models; Lopinavir; Nevirapine; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Pyrimidinones; Ritonavir; Statistics, Nonparametric; Tenofovir; Treatment Failure; Young Adult | 2010 |
Population pharmacokinetics of nevirapine in HIV-1-infected pregnant women and their neonates.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Infant, Newborn; Nevirapine; Organophosphonates; Pregnancy; Tenofovir; Treatment Outcome; Young Adult; Zidovudine | 2011 |
Concomitant administration of BILR 355/r with emtricitabine/tenofovir disoproxil fumarate increases exposure to emtricitabine and tenofovir: a randomized, open-label, prospective study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Azepines; Cross-Over Studies; Deoxycytidine; Drug Interactions; Emtricitabine; Female; Half-Life; HIV Protease Inhibitors; Humans; Male; Metabolic Clearance Rate; Middle Aged; Organophosphonates; Pyridines; Reproducibility of Results; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Young Adult | 2011 |
Tenofovir disoproxil fumarate rescue therapy following failure of both lamivudine and adefovir dipivoxil in chronic hepatitis B.
Topics: Adenine; Adult; Aged; Aged, 80 and over; DNA, Viral; Drug Resistance, Viral; Epidemiologic Methods; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Salvage Therapy; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load; Young Adult | 2011 |
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Follow-Up Studies; HIV; HIV Antibodies; HIV Infections; HIV Seropositivity; Homosexuality, Male; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Nausea; Organophosphonates; Patient Compliance; RNA, Viral; Tenofovir; Transsexualism; Young Adult | 2010 |
Effect of boosted fosamprenavir or lopinavir-based combinations on whole-body insulin sensitivity and lipids in treatment-naive HIV-type-1-positive men.
Topics: Adenine; Adipose Tissue; Adult; Anti-HIV Agents; Blood Glucose; Carbamates; Confidence Intervals; Drug Administration Schedule; Drug Combinations; Dyslipidemias; Furans; HIV Infections; HIV-1; Humans; Insulin; Insulin Resistance; Lamivudine; Lipids; Lopinavir; Male; Organophosphates; Organophosphonates; Pyrimidinones; Ritonavir; Sulfonamides; Tenofovir | 2010 |
Low level of the K103N HIV-1 above a threshold is associated with virological failure in treatment-naive individuals undergoing efavirenz-containing therapy.
Topics: Adenine; Adult; Alkynes; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Tenofovir; Treatment Failure; Viral Load | 2011 |
[Efficacy of the 96-week adefovir dipivoxil therapy in patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Lamivudine; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Young Adult | 2010 |
[Observation on effect of peg interferon lphaa-2a treating lamivudine resistant chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Watchful Waiting | 2010 |
[Efficacy of adefovir treatment in the lamivudine-resistant chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Treatment Failure; Young Adult | 2010 |
Tenofovir disoproxil fumarate (TDF), emtricitabine/TDF, and entecavir in patients with decompensated chronic hepatitis B liver disease.
Topics: Adenine; Adolescent; Adult; Aged; Creatinine; Deoxycytidine; DNA, Viral; Drug Combinations; Emtricitabine; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Load | 2011 |
Peginterferon plus adefovir versus either drug alone for hepatitis delta.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Analysis of Variance; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B Surface Antigens; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; RNA, Viral; Viral Load; Young Adult | 2011 |
Interim guidance: preexposure prophylaxis for the prevention of HIV infection in men who have sex with men.
Topics: Adenine; Antiviral Agents; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Tenofovir; Unsafe Sex | 2011 |
Co-enrollment in multiple HIV prevention trials - experiences from the CAPRISA 004 Tenofovir gel trial.
Topics: Adenine; Adult; Africa South of the Sahara; Anti-HIV Agents; Clinical Trials, Phase II as Topic; Female; Gels; HIV Infections; Humans; Organophosphonates; Patient Participation; Patient Selection; Randomized Controlled Trials as Topic; Self Report; Tenofovir; Young Adult | 2011 |
[Influence of adefovir dipivoxil on HBV specific CTL in patients with chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; T-Lymphocytes, Cytotoxic; Young Adult | 2010 |
Intracellular nucleotide levels during coadministration of tenofovir disoproxil fumarate and didanosine in HIV-1-infected patients.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Chromatography, Liquid; Deoxyadenine Nucleotides; Deoxyguanine Nucleotides; Didanosine; Dideoxynucleotides; Female; HIV Infections; Humans; Male; Middle Aged; Nucleotides; Organophosphonates; Tandem Mass Spectrometry; Tenofovir; Young Adult | 2011 |
Atazanavir pharmacokinetics with and without tenofovir during pregnancy.
Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Infectious Disease Transmission, Vertical; Oligopeptides; Organophosphonates; Postpartum Period; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Prospective Studies; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome | 2011 |
A randomized trial to assess anti-HIV activity in female genital tract secretions and soluble mucosal immunity following application of 1% tenofovir gel.
Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Female; Genitalia, Female; HIV Infections; Humans; Immunity, Mucosal; Mucous Membrane; Organophosphonates; Semen; Tenofovir; Vaginal Douching; Young Adult | 2011 |
Tenofovir improves the outcome in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; India; Liver Failure, Acute; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2011 |
Early changes in inflammatory and pro-thrombotic biomarkers in patients initiating antiretroviral therapy with abacavir or tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; C-Reactive Protein; Coagulants; Dideoxynucleosides; Female; HIV Infections; Humans; Inflammation Mediators; Interleukin-6; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Plasminogen Activator Inhibitor 1; Tenofovir; Thrombosis; Vascular Cell Adhesion Molecule-1 | 2011 |
Virological characterization of patients failing darunavir/ritonavir or lopinavir/ritonavir treatment in the ARTEMIS study: 96-week analysis.
Topics: Adenine; Adult; Anti-HIV Agents; Darunavir; Deoxycytidine; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Genetic Association Studies; HIV Infections; HIV-1; Humans; Lopinavir; Male; Mutation; Organophosphonates; Polymorphism, Genetic; Pyrimidinones; Ritonavir; RNA, Viral; Sulfonamides; Tenofovir; Treatment Failure; Viral Load | 2011 |
Evaluation of adefovir & lamivudine in chronic hepatitis B: correlation with HBV viral kinetic, hepatic-necro inflammation & fibrosis.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Inflammation; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Pilot Projects; Prospective Studies; Reverse Transcriptase Inhibitors; Young Adult | 2011 |
Association of intrahepatic cccDNA reduction with the improvement of liver histology in chronic hepatitis B patients receiving oral antiviral agents.
Topics: Adenine; Adult; Antiviral Agents; Blood; DNA, Circular; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Histocytochemistry; Humans; Liver; Male; Middle Aged; Organophosphonates; Placebos; Treatment Outcome; Viral Load | 2011 |
Tenofovir discontinuation could predispose to urolithiasis in atazanavir-treated patients.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Drug Administration Schedule; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Male; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Urolithiasis | 2011 |
Bioequivalence study of two oral tablet formulations containing tenofovir disoproxil fumarate in healthy volunteers.
Topics: Adenine; Adult; Blood Cell Count; Blood Chemical Analysis; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Food-Drug Interactions; Humans; Intestinal Absorption; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Spectrometry, Fluorescence; Tablets; Tenofovir; Therapeutic Equivalency; Young Adult | 2011 |
Initial results reported on raltegravir once-daily dosing.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV Integrase Inhibitors; Humans; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Treatment Outcome | 2011 |
No resistance to tenofovir disoproxil fumarate detected after up to 144 weeks of therapy in patients monoinfected with chronic hepatitis B virus.
Topics: Adenine; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Gene Products, pol; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; RNA-Directed DNA Polymerase; Tenofovir | 2011 |
Metabolic benefits of switching to tenofovir/lamivudine after long-term use of stavudine/lamivudine in NNRTI-based antiretroviral regimens: a prospective study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Female; HIV Infections; Humans; Lamivudine; Lipid Metabolism; Male; Middle Aged; Organophosphonates; Prospective Studies; Stavudine; Tenofovir; Treatment Outcome | 2011 |
Recruitment of high risk women for HIV prevention trials: baseline HIV prevalence and sexual behavior in the CAPRISA 004 tenofovir gel trial.
Topics: Adenine; Administration, Intravaginal; Adolescent; Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Organophosphonates; Patient Selection; Prevalence; Reverse Transcriptase Inhibitors; Risk Assessment; Risk Factors; Rural Population; Sex Factors; Sexual Behavior; South Africa; Tenofovir; Treatment Outcome; Urban Population; Vaginal Creams, Foams, and Jellies; Women's Health; Young Adult | 2011 |
Randomized, phase 2 evaluation of two single-tablet regimens elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate for the initial treatment of HIV infection.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; CD4 Lymphocyte Count; Cobicistat; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Patient Compliance; Patient Selection; Quinolones; Tenofovir; Thiazoles; Treatment Outcome | 2011 |
Very high concentrations of active intracellular phosphorylated emtricitabine in neonates (ANRS 12109 trial, step 2).
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Antiviral Agents; Deoxycytidine; Emtricitabine; Female; HIV-1; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Maternal-Fetal Exchange; Organophosphonates; Phosphorylation; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Tenofovir | 2011 |
Plasma and intracellular tenofovir pharmacokinetics in the neonate (ANRS 12109 trial, step 2).
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Female; HIV-1; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir | 2011 |
Beliefs about antiretroviral therapy, treatment adherence and quality of life in a 48-week randomised study of continuation of zidovudine/lamivudine or switch to tenofovir DF/emtricitabine, each with efavirenz.
Topics: Adenine; Adult; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Drug Substitution; Drug Therapy, Combination; Emtricitabine; Female; Health Knowledge, Attitudes, Practice; HIV Infections; HIV-1; Humans; Lamivudine; Male; Medication Adherence; Middle Aged; Organophosphonates; Quality of Life; Tenofovir; Treatment Outcome; Young Adult; Zidovudine | 2011 |
Efficacy and safety of entecavir versus adefovir in chronic hepatitis B patients with hepatic decompensation: a randomized, open-label study.
Topics: Adenine; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Failure; Male; Middle Aged; Organophosphonates; Survival Rate; Treatment Outcome | 2011 |
Lipid profiles for nevirapine vs. atazanavir/ritonavir, both combined with tenofovir disoproxil fumarate and emtricitabine over 48 weeks, in treatment-naïve HIV-1-infected patients (the ARTEN study).
Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; Deoxycytidine; Drug Therapy, Combination; Dyslipidemias; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lipids; Male; Nevirapine; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Viral Load | 2011 |
Nevirapine versus atazanavir/ritonavir, each combined with tenofovir disoproxil fumarate/emtricitabine, in antiretroviral-naive HIV-1 patients: the ARTEN Trial.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Cardiovascular Diseases; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nevirapine; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome | 2011 |
Intrahepatic response markers in chronic hepatitis B patients treated with peginterferon alpha-2a and adefovir.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Biopsy; Chi-Square Distribution; DNA, Circular; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunohistochemistry; Interferon-alpha; Liver; Male; Middle Aged; Netherlands; Organophosphonates; Polyethylene Glycols; Polymerase Chain Reaction; Predictive Value of Tests; Recombinant Proteins; Time Factors; Treatment Outcome; Viral Load | 2011 |
Bone mineral density and fractures in antiretroviral-naive persons randomized to receive abacavir-lamivudine or tenofovir disoproxil fumarate-emtricitabine along with efavirenz or atazanavir-ritonavir: Aids Clinical Trials Group A5224s, a substudy of ACTG
Topics: Absorptiometry, Photon; Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Bone Density; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Female; Fractures, Bone; HIV Infections; Humans; Intention to Treat Analysis; Lamivudine; Male; Middle Aged; Oligopeptides; Organophosphonates; Osteoporosis; Pyridines; Risk Factors; Ritonavir; Tenofovir; Viral Load | 2011 |
Steady-state pharmacokinetics of tenofovir-based regimens in HIV-infected pediatric patients.
Topics: Adenine; Adolescent; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Child; Cyclopropanes; Drug Administration Schedule; Female; HIV Infections; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir | 2011 |
Low-density lipoprotein size and lipoprotein-associated phospholipase A2 in HIV-infected patients switching to abacavir or tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Cardiovascular Diseases; Cholesterol, LDL; Clinical Protocols; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lipoproteins; Lipoproteins, LDL; Male; Middle Aged; Organophosphonates; Phospholipases A2; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
[Safety and efficacy of Entecavir combined with Adefovir in patients with chronic hepatitis B who fail to respond to nucleoside analog treatment].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates; Treatment Failure | 2011 |
Randomised clinical trial: efficacy of peginterferon alfa-2a in HBeAg positive chronic hepatitis B patients with lamivudine resistance.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; China; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Time Factors; Treatment Outcome; Young Adult | 2011 |
Simple scoring system predicting genotypic resistance during rescue therapy for Lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Retrospective Studies; Survival Analysis; Treatment Outcome; Young Adult | 2012 |
Treatment of advanced HIV disease in antiretroviral-naïve HIV-1-infected patients receiving once-daily atazanavir/ritonavir or twice-daily lopinavir/ritonavir, each in combination with tenofovir disoproxil fumarate and emtricitabine.
Topics: Adenine; Adult; Aged; Antiviral Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Young Adult | 2011 |
Hepatitis D virus-specific cytokine responses in patients with chronic hepatitis delta before and during interferon alfa-treatment.
Topics: Adenine; Adult; Analysis of Variance; Antiviral Agents; Cells, Cultured; Chi-Square Distribution; Cytokines; Drug Therapy, Combination; Europe; Female; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Interferon-alpha; Leukocytes, Mononuclear; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; RNA, Viral; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2011 |
Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Emtricitabine; Female; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Mutation; Nitriles; Nucleosides; Nucleotides; Organophosphonates; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; Treatment Outcome; Viral Load | 2011 |
Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Aged; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Emtricitabine; Female; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Mutation; Nitriles; Organophosphonates; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; Treatment Outcome; Viral Load | 2011 |
Efficacy and tolerance of a combination of tenofovir disoproxil fumarate plus emtricitabine in patients with chronic hepatitis B: a European multicenter study.
Topics: Adenine; Adult; Aged; Antiviral Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Europe; Follow-Up Studies; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2011 |
Effects of the H2-receptor antagonist famotidine on the pharmacokinetics of atazanavir-ritonavir with or without tenofovir in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Cohort Studies; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Famotidine; Female; Histamine H2 Antagonists; HIV Infections; Humans; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Viral Load | 2011 |
Phase 2 study of cobicistat versus ritonavir each with once-daily atazanavir and fixed-dose emtricitabine/tenofovir df in the initial treatment of HIV infection.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Carbamates; CD4 Lymphocyte Count; Cobicistat; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; RNA, Viral; Tenofovir; Thiazoles; Treatment Outcome | 2011 |
Lamivudine plus adefovir is a good option for chronic hepatitis B patients with viral relapse after cessation of lamivudine treatment.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Prospective Studies; Recurrence; Salvage Therapy; Treatment Outcome; Withholding Treatment | 2011 |
Randomized comparison of metabolic and renal effects of saquinavir/r or atazanavir/r plus tenofovir/emtricitabine in treatment-naïve HIV-1-infected patients.
Topics: Adenine; Adult; Atazanavir Sulfate; Deoxycytidine; Drug Administration Schedule; Dyslipidemias; Emtricitabine; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Male; Oligopeptides; Organophosphonates; Pyridines; Saquinavir; Tenofovir; Treatment Outcome | 2011 |
[One-year combination therapy de novo of adefovir dipivoxil and lamivudine for decompensated cirrhosis related to HBV].
Topics: Adenine; Adult; Antiviral Agents; China; Drug Therapy, Combination; Female; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2011 |
[The levels of HBsAg can predict the efficacy of peglated interferon-alpha 2a combined with adefovir dipivoxil, in HBeAg-positive chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Organophosphonates; Recombinant Proteins; Treatment Outcome | 2011 |
Predicting product adherence in a topical microbicide safety trial in Pune, India.
Topics: Adenine; Adolescent; Adult; Anti-Infective Agents; Anti-Infective Agents, Local; Condoms; Female; HIV Infections; Humans; India; Medication Adherence; Middle Aged; Organophosphonates; Predictive Value of Tests; Prospective Studies; Risk Reduction Behavior; Sexual Partners; Social Support; Socioeconomic Factors; Tenofovir; Young Adult | 2012 |
Pharmacokinetics and safety of single-dose tenofovir disoproxil fumarate and emtricitabine in HIV-1-infected pregnant women and their infants.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Infant; Infectious Disease Transmission, Vertical; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Young Adult | 2011 |
Plasma and intracellular population pharmacokinetic analysis of tenofovir in HIV-1-infected patients.
Topics: Adenine; Adolescent; Adult; Chromatography, Liquid; Female; Humans; Male; Middle Aged; Organophosphonates; Tandem Mass Spectrometry; Tenofovir; Young Adult | 2011 |
Bone mineral density in HIV-negative men participating in a tenofovir pre-exposure prophylaxis randomized clinical trial in San Francisco.
Topics: Absorptiometry, Photon; Adenine; Adolescent; Adult; Anti-HIV Agents; Bone Density; Eligibility Determination; Fractures, Bone; HIV Seronegativity; Homosexuality, Male; Humans; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Preventive Health Services; San Francisco; Tenofovir; Young Adult | 2011 |
Abacavir/lamivudine versus tenofovir DF/emtricitabine as part of combination regimens for initial treatment of HIV: final results.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Double-Blind Method; Emtricitabine; Female; HIV; HIV Infections; Humans; Kaplan-Meier Estimate; Lamivudine; Male; Middle Aged; Organophosphonates; RNA, Viral; Tenofovir; Viral Load | 2011 |
Long-term treatment with raltegravir or efavirenz combined with tenofovir/emtricitabine for treatment-naive human immunodeficiency virus-1-infected patients: 156-week results from STARTMRK.
Topics: Absorptiometry, Photon; Adenine; Adolescent; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2011 |
Clinical outcomes of lamivudine-adefovir therapy in chronic hepatitis B cirrhosis.
Topics: Adenine; Aged; Antiviral Agents; Cohort Studies; Disease Progression; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Proportional Hazards Models; Prospective Studies; Risk Factors; Severity of Illness Index; Survival Rate; Treatment Outcome | 2011 |
Pharmacokinetics and placental transfer of single-dose tenofovir 1% vaginal gel in term pregnancy.
Topics: Adenine; Adult; Amniotic Fluid; Anti-HIV Agents; Cesarean Section; Endometrium; Female; Fetal Blood; Humans; Maternal-Fetal Exchange; Organophosphonates; Placenta; Pregnancy; Tenofovir; Vaginal Creams, Foams, and Jellies | 2011 |
Contraceptive choices, pregnancy rates, and outcomes in a microbicide trial.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Anti-Infective Agents; Contraceptive Agents; Contraceptive Agents, Female; Female; Humans; Medroxyprogesterone Acetate; Organophosphonates; Pregnancy; Pregnancy Rate; Progestins; South Africa; Tenofovir; Young Adult | 2011 |
Virological response and resistance profiles after 24 months of first-line antiretroviral treatment in adults living in Bangui, Central African Republic.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Central African Republic; DNA Fingerprinting; Drug Resistance, Viral; Female; Genetic Variation; Health Services Accessibility; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Medication Adherence; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Viral Load; Young Adult; Zidovudine | 2012 |
Enrollment characteristics and risk behaviors of injection drug users participating in the Bangkok Tenofovir Study, Thailand.
Topics: Adenine; Administration, Oral; Adult; AIDS Vaccines; Communicable Disease Control; Double-Blind Method; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Placebos; Risk; Risk-Taking; Substance Abuse, Intravenous; Tenofovir; Thailand | 2011 |
Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; Cardiovascular Diseases; Deoxycytidine; Dideoxynucleosides; E-Selectin; Emtricitabine; Female; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Plasma; Tenofovir; Vascular Cell Adhesion Molecule-1 | 2011 |
[Relationship between HBeAg seroconversion with genotypes and HBV specific CTL in patients with chronic hepatitis B treated with Adefovir dipivoxil].
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunity, Cellular; Male; Organophosphonates; T-Lymphocytes, Cytotoxic | 2011 |
A randomized, pilot trial to evaluate glomerular filtration rate by creatinine or cystatin C in naive HIV-infected patients after tenofovir/emtricitabine in combination with atazanavir/ritonavir or efavirenz.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Creatinine; Cyclopropanes; Cystatin C; Deoxycytidine; Emtricitabine; Female; Glomerular Filtration Rate; HIV Infections; Humans; Male; Middle Aged; Oligopeptides; Organophosphonates; Pilot Projects; Pyridines; Ritonavir; Tenofovir | 2012 |
Characteristics of HIV-1 serodiscordant couples enrolled in a clinical trial of antiretroviral pre-exposure prophylaxis for HIV-1 prevention.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Cohort Studies; Deoxycytidine; Emtricitabine; Female; Heterosexuality; HIV Infections; HIV Seronegativity; HIV Seropositivity; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Risk-Taking; Sexual Behavior; Tenofovir; Young Adult | 2011 |
Glomerular dysfunction and associated risk factors over 4-5 years following antiretroviral therapy initiation in Africa.
Topics: Adenine; Adult; Africa; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Creatinine; Dideoxynucleosides; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Kidney Glomerulus; Lamivudine; Male; Nevirapine; Organophosphonates; Risk Factors; Tenofovir; Time Factors; Zidovudine | 2011 |
A multi-compartment, single and multiple dose pharmacokinetic study of the vaginal candidate microbicide 1% tenofovir gel.
Topics: Adenine; Administration, Topical; Adult; Female; Gels; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Vagina | 2011 |
Predictors of limb fat gain in HIV positive patients following a change to tenofovir-emtricitabine or abacavir-lamivudine.
Topics: Adenine; Adipose Tissue; Adult; Biomarkers; Body Fat Distribution; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Extremities; HIV Infections; Humans; Lamivudine; Middle Aged; Organophosphonates; Predictive Value of Tests; Tenofovir | 2011 |
A randomized crossover study to determine relative bioequivalence of tenofovir, emtricitabine, and efavirenz (Atripla) fixed-dose combination tablet compared with a compounded oral liquid formulation derived from the tablet.
Topics: Adenine; Administration, Oral; Adult; Aged; Cross-Over Studies; Deoxycytidine; Drug Combinations; Drug Compounding; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; Humans; Male; Middle Aged; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Tablets; Therapeutic Equivalency; Treatment Outcome; Water | 2011 |
Changes in condom use during a microbicide clinical trial in Pune, India.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Condoms; Counseling; Female; Follow-Up Studies; Gels; Health Knowledge, Attitudes, Practice; HIV Infections; Humans; India; Male; Middle Aged; Odds Ratio; Organophosphonates; Risk Factors; Risk Reduction Behavior; Sex Distribution; Sexual Behavior; Sexual Partners; Surveys and Questionnaires; Tenofovir; Young Adult | 2012 |
Long-term adefovir plus lamivudine therapy does not decrease creatinine clearance in HBeAg-negative chronic hepatitis B patients.
Topics: Adenine; Adult; Age Factors; Aged; Creatine; Drug Resistance, Viral; Drug Therapy, Combination; Female; Greece; Hepatitis B; Hepatitis B e Antigens; Humans; Kidney; Lamivudine; Linear Models; Male; Middle Aged; Organophosphonates | 2011 |
[Efficacy of two nucleoside analogs to treat resistant HBeAg-negative chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Drug Resistance, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2011 |
Five years of treatment with adefovir dipivoxil in Chinese patients with HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Asian People; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Function Tests; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome; Viral Load; Viremia; Young Adult | 2012 |
The influence of YMDD mutation patterns on clinical outcomes in patients with adefovir add-on lamivudine combination treatment.
Topics: Adenine; Adult; Alanine Transaminase; Amino Acid Motifs; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Humans; Lamivudine; Liver Function Tests; Male; Mutation; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
Pharmacokinetics and inhibitory quotient of atazanavir/ritonavir versus lopinavir/ritonavir in HIV-infected, treatment-naive patients who participated in the CASTLE Study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir | 2012 |
HIV-1 protease inhibitors and clinical malaria: a secondary analysis of the AIDS Clinical Trials Group A5208 study.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Incidence; Lopinavir; Malaria; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome | 2012 |
Dynamics of cognitive change in HIV-infected individuals commencing three different initial antiretroviral regimens: a randomized, controlled study.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cognition; Cognition Disorders; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Zidovudine | 2012 |
[Clinical antiviral effects of Peg-IFNa-2a in patients with chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2011 |
The setpoint study (ACTG A5217): effect of immediate versus deferred antiretroviral therapy on virologic set point in recently HIV-1-infected individuals.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Disease Progression; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2012 |
Genetic variation in IL28B and treatment outcome in HBeAg-positive and -negative chronic hepatitis B patients treated with Peg interferon alfa-2a and adefovir.
Topics: Adenine; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Therapy, Combination; Ethnicity; Follow-Up Studies; Genetic Variation; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Interferons; Interleukins; Organophosphonates; Polyethylene Glycols; Polymorphism, Single Nucleotide; Prospective Studies; Recombinant Proteins; Treatment Outcome | 2012 |
Raltegravir, tenofovir DF, and emtricitabine for postexposure prophylaxis to prevent the sexual transmission of HIV: safety, tolerability, and adherence.
Topics: Adenine; Adult; Anti-HIV Agents; Boston; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Patient Compliance; Post-Exposure Prophylaxis; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Young Adult | 2012 |
What's love got to do with it? Explaining adherence to oral antiretroviral pre-exposure prophylaxis for HIV-serodiscordant couples.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Attitude to Health; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV Seronegativity; HIV Seropositivity; Humans; Interpersonal Relations; Male; Medication Adherence; Middle Aged; Organophosphonates; Sexual Partners; Tenofovir; Uganda; Young Adult | 2012 |
Vitamin D3 decreases parathyroid hormone in HIV-infected youth being treated with tenofovir: a randomized, placebo-controlled trial.
Topics: Adenine; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cholecalciferol; Double-Blind Method; Drug Interactions; Female; HIV Infections; Humans; Male; Multicenter Studies as Topic; Organophosphonates; Parathyroid Hormone; Placebos; Tenofovir; Vitamins; Young Adult | 2012 |
Drug interaction profile for GSK2248761, a next generation non-nucleoside reverse transcriptase inhibitor.
Topics: Adenine; Androstenes; Anti-HIV Agents; Atazanavir Sulfate; Atorvastatin; Contraceptives, Oral; Cross-Over Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Darunavir; Deoxycytidine; Double-Blind Method; Drug Combinations; Drug Interactions; Emtricitabine; Ethinyl Estradiol; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Least-Squares Analysis; Linear Models; Lopinavir; Male; Oligopeptides; Organophosphonates; Patient Safety; Phosphinic Acids; Pyridines; Pyrimidines; Pyrroles; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Risk Assessment; Ritonavir; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Tenofovir | 2012 |
Mitochondrial function, inflammation, fat and bone in HIV lipoatrophy: randomized study of uridine supplementation or switch to tenofovir.
Topics: Adenine; Adipocytes; Adipose Tissue; Adult; Anti-HIV Agents; Apoptosis; Bone Density; DNA, Mitochondrial; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Inflammation; Male; Middle Aged; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; RNA; RNA, Mitochondrial; Tenofovir; Uridine; Viral Load | 2012 |
Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones.
Topics: Adenine; Adipose Tissue; Adult; Alkynes; Anaerobiosis; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Electron Transport Complex IV; Female; Gene Expression Regulation; HIV Infections; HIV-1; Humans; Ion Channels; Lipogenesis; Male; Middle Aged; Mitochondrial Proteins; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Uncoupling Protein 2; Zidovudine | 2012 |
A randomized study of tenofovir disoproxil fumarate in treatment-experienced HIV-1 infected adolescents.
Topics: Adenine; Adolescent; Anti-HIV Agents; Child; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Outcome; Viremia | 2012 |
[A clinical study on the efficacy of HBeAg-positive chronic hepatitis B patients treated with adefovir dipivoxil for 4 years].
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Virus Replication | 2011 |
Treatment outcomes of recommended first-line antiretroviral regimens in resource-limited clinics.
Topics: Adenine; Adult; Age Factors; Anti-HIV Agents; CD4 Lymphocyte Count; Cross-Sectional Studies; Deoxycytidine; Developing Countries; Drug Costs; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Nevirapine; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2012 |
Treatment response and evolution of HBV resistance during lamivudine plus adefovir or entecavir therapy in patients with adefovir-resistant mutants.
Topics: Adenine; Adult; Aged; Antiviral Agents; Base Sequence; Cloning, Molecular; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates | 2012 |
Changes in body composition and mitochondrial DNA in HIV-1-infected patients switching to fixed-dose abacavir/lamivudine or tenofovir/emtricitabine: a substudy of the BICOMBO trial.
Topics: Adenine; Adult; Anti-HIV Agents; Body Composition; Bone Density; Deoxycytidine; Dideoxynucleosides; DNA, Mitochondrial; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir | 2012 |
[Polish multicenter study on safety and efficacy of adefovir dipivoxil in the treatment of lamivudine resistant chronic hepatitis B in adults (HEP 2008)].
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Poland; Treatment Outcome; Viral Load | 2011 |
Relative bioavailability study of a novel prodrug of tenofovir, tenofovir dipivoxil fumarate, in healthy male fasted volunteers.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Hepatitis B; Humans; Male; Middle Aged; Organophosphonates; Phosphorous Acids; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir; Therapeutic Equivalency; Young Adult | 2012 |
Effect of gender and race on the week 48 findings in treatment-naïve, HIV-1-infected patients enrolled in the randomized, phase III trials ECHO and THRIVE.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Black or African American; CD4 Lymphocyte Count; Cyclopropanes; Dideoxynucleosides; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Nitriles; Organophosphonates; Pyrimidines; Rilpivirine; Sex Factors; Tenofovir; Treatment Outcome; Viral Load; Zidovudine | 2012 |
Prevention of de novo hepatitis B with adefovir dipivoxil in recipients of liver grafts from hepatitis B core antibody-positive donors.
Topics: Adenine; Adult; Aged; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Humans; Liver; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Tissue Donors | 2012 |
Randomized trial of entecavir plus adefovir in patients with lamivudine-resistant chronic hepatitis B who show suboptimal response to lamivudine plus adefovir.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
[Entecavir 1.0mg monotherapy or entecavir plus adefovir dipivoxil for patients with lamivudine-resistant chronic hepatitis B had suboptimal response to lamivudine plus adefovir dipivoxil].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2011 |
Improved efficacy by individualized combination therapy with Peg IFN-a 2a and ADV in HBeAg positive chronic hepatitis B patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Chi-Square Distribution; China; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Precision Medicine; Prospective Studies; Recombinant Proteins; Time Factors; Treatment Outcome | 2012 |
A comparison of measured and estimated glomerular filtration rate in successfully treated HIV-patients with preserved renal function.
Topics: Adenine; Adult; Anti-HIV Agents; Body Mass Index; Deoxycytidine; Emtricitabine; Female; Glomerular Filtration Rate; HIV Infections; Humans; Lamivudine; Linear Models; Male; Middle Aged; Netherlands; Organophosphonates; Pilot Projects; Research Design; Statistics, Nonparametric; Tenofovir; Treatment Outcome; Zidovudine | 2012 |
Randomised clinical trial: the benefit of combination therapy with adefovir and lamivudine for chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2012 |
Supporting study product use and accuracy in self-report in the iPrEx study: next step counseling and neutral assessment.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Deoxycytidine; Directive Counseling; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Follow-Up Studies; Health Knowledge, Attitudes, Practice; Homosexuality, Male; Humans; Male; Medication Adherence; Organophosphonates; Patient Acceptance of Health Care; Self Report; Sexual Partners; Tenofovir; Transsexualism | 2012 |
[Efficacy of lamivudine and adefovir de novo combination therapy or after mono-therapy in chronic hepatitis B patients].
Topics: Adenine; Adult; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Treatment Outcome | 2012 |
Efficacy and safety of long-term adefovir dipivoxil therapy in children with chronic hepatitis B infection.
Topics: Adenine; Adolescent; Child; Child, Preschool; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Placebos; Treatment Outcome | 2012 |
Comparison of bone and renal effects in HIV-infected adults switching to abacavir or tenofovir based therapy in a randomized trial.
Topics: Adenine; Adult; Alkaline Phosphatase; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; Bone and Bones; Bone Density; Creatinine; Cystatin C; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV Infections; Humans; Kidney; Kidney Function Tests; Lamivudine; Male; Middle Aged; Organophosphonates; Osteocalcin; Tenofovir; Time Factors; Treatment Outcome | 2012 |
Safety and adherence to intermittent pre-exposure prophylaxis (PrEP) for HIV-1 in African men who have sex with men and female sex workers.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Homosexuality, Male; Humans; Kenya; Male; Middle Aged; Organophosphonates; Patient Compliance; Sex Workers; Tenofovir | 2012 |
Randomized, placebo-controlled trial of tenofovir disoproxil fumarate in adolescents with chronic hepatitis B.
Topics: Adenine; Adolescent; Alanine Transaminase; Antiviral Agents; Bone Density; Child; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Tenofovir; Viral Load | 2012 |
Inflammation markers after randomization to abacavir/lamivudine or tenofovir/emtricitabine with efavirenz or atazanavir/ritonavir.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Biomarkers; C-Reactive Protein; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV-1; Humans; Inflammation; Interleukin-6; Lamivudine; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Tumor Necrosis Factor-alpha | 2012 |
CAPRISA 004 tenofovir microbicide trial: no impact of tenofovir gel on the HIV transmission bottleneck.
Topics: Adenine; Anti-HIV Agents; Anti-Infective Agents, Local; Cervix Uteri; Cohort Studies; Female; Gels; HIV Infections; HIV-1; Humans; Mucous Membrane; Organophosphonates; Tenofovir | 2012 |
Renal function during treatment with adefovir plus peginterferon alfa-2a vs either drug alone in hepatitis B/D co-infection.
Topics: Adenine; Adolescent; Adult; Aged; Aleutian Mink Disease Virus; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis D; Humans; Interferon-alpha; Kidney; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Retrospective Studies; Young Adult | 2012 |
[Clinical study on Baihua Xianglian detoxification recipe combined with adefovir dipivoxil in treating HBeAg positive chronic hepatitis].
Topics: Adenine; Adult; Antiviral Agents; Drugs, Chinese Herbal; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Phytotherapy; Treatment Outcome; Young Adult | 2012 |
Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial.
Topics: Abortion, Spontaneous; Adenine; Adult; Anti-HIV Agents; Body Height; Body Weight; Breast Feeding; Burns; Cause of Death; Child, Preschool; Congenital Abnormalities; Drug Combinations; Female; Follow-Up Studies; Fractures, Bone; Growth; HIV Infections; HIV Seropositivity; Humans; Infant; Infant Mortality; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Male; Measles; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Prevalence; Respiratory Tract Infections; Tenofovir; Uganda; Zidovudine; Zimbabwe | 2012 |
Efficacy of entecavir with or without tenofovir disoproxil fumarate for nucleos(t)ide-naïve patients with chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Linear Models; Organophosphonates; Phosphorous Acids; Time Factors; Treatment Outcome; Viral Load | 2012 |
Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long-term treatment with adefovir.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Prospective Studies; Recurrence; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2012 |
Virologic responses to add-on adefovir dipivoxil treatment versus entecavir monotherapy in children with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adolescent; Antiviral Agents; Child; Child, Preschool; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
[Experimental study on effect of dahuang zhechong wan combined with adefovir dipivoxil in preventing hepatic fibrosis in patients with chronic hepatitis B].
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
Changes in bone turnover and bone loss in HIV-infected patients changing treatment to tenofovir-emtricitabine or abacavir-lamivudine.
Topics: Absorptiometry, Photon; Adenine; Adult; Bone Density; Bone Remodeling; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Rescue therapy for lamivudine-resistant chronic hepatitis B: adefovir monotherapy, adefovir plus lamivudine or entecavir combination therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Time Factors | 2012 |
Lamivudine plus adefovir or telbivudine plus adefovir for chronic hepatitis B patients with suboptimal response to adefovir.
Topics: Adenine; Adult; Biomarkers; DNA, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Nucleosides; Organophosphonates; Prospective Studies; Pyrimidinones; Telbivudine; Thymidine; Treatment Outcome; Young Adult | 2012 |
[The clinical efficacy and safety of adefovir dipivoxil in combination with bicyclol for the treatment of senior patients with chronic hepatitis B].
Topics: Adenine; Aged; Aged, 80 and over; Antiviral Agents; Biphenyl Compounds; DNA, Viral; Female; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates | 2011 |
From in vitro EC₅₀ to in vivo dose-response for antiretrovirals using an HIV disease model. Part I: a framework.
Topics: Adenine; Anti-HIV Agents; Cyclohexanes; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV-1; Humans; Inhibitory Concentration 50; Male; Maraviroc; Models, Biological; Nitriles; Organophosphonates; Oxazines; Piperazines; Pyridazines; Pyridones; Pyrimidines; RNA, Viral; Tenofovir; Triazoles | 2012 |
Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Cobicistat; Deoxycytidine; Double-Blind Method; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Quinolones; Ritonavir; Tenofovir; Thiazoles | 2012 |
Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; Cobicistat; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Quinolones; Tenofovir; Thiazoles | 2012 |
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Topics: Adenine; Adolescent; Adult; Anti-Retroviral Agents; Contraception Behavior; Deoxycytidine; Double-Blind Method; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Female; Heterosexuality; HIV Infections; HIV Seropositivity; HIV-1; Humans; Incidence; Male; Middle Aged; Organophosphonates; Pregnancy; RNA, Viral; Sexual Behavior; Tenofovir; Young Adult | 2012 |
Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana.
Topics: Adenine; Adolescent; Adult; Anti-Retroviral Agents; Bone Density; Contraception Behavior; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Seropositivity; HIV-1; HIV-2; Humans; Kaplan-Meier Estimate; Male; Organophosphonates; Proportional Hazards Models; RNA, Viral; Sexual Behavior; Tenofovir; Viral Load; Young Adult | 2012 |
Preexposure prophylaxis for HIV infection among African women.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Anti-Retroviral Agents; Case-Control Studies; Deoxycytidine; Double-Blind Method; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV Seropositivity; HIV-1; Humans; Incidence; Kaplan-Meier Estimate; Medication Adherence; Organophosphonates; Risk-Taking; RNA, Viral; Sexual Behavior; Tenofovir; Treatment Failure; Viral Load; Young Adult | 2012 |
Tenofovir use and renal insufficiency among pregnant and general adult population of HIV-infected, ART-naïve individuals in Lilongwe, Malawi.
Topics: Adenine; Adolescent; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Body Mass Index; CD4 Lymphocyte Count; Creatinine; Cyclopropanes; Drug Combinations; Female; HIV Infections; Humans; Lamivudine; Malawi; Male; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Renal Insufficiency; Tenofovir | 2012 |
Clonal analysis of the quasispecies of antiviral-resistant HBV genomes in patients with entecavir resistance during rescue treatment and successful treatment of entecavir resistance with tenofovir.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genome, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Tenofovir; Treatment Outcome; Young Adult | 2013 |
Safety of tenofovir gel, a vaginal microbicide, in South African women: results of the CAPRISA 004 Trial.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Anti-Infective Agents, Local; Bone and Bones; Female; Follow-Up Studies; Gastrointestinal Tract; HIV Infections; Humans; Kidney; Organophosphonates; South Africa; Tenofovir; Vaginal Creams, Foams, and Jellies | 2013 |
RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate.
Topics: Adenine; Administration, Oral; Administration, Rectal; Adult; Aged; Anti-HIV Agents; Double-Blind Method; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Patient Satisfaction; Rectum; Tenofovir; Treatment Outcome; United States; Vaginal Creams, Foams, and Jellies | 2012 |
[The therapeutic effect of Anluohuaxian capsule combined with adefovir dipivoxil on patients with chronic hepatitis B and influence on hepatic histology].
Topics: Adenine; Adult; Antiviral Agents; Drugs, Chinese Herbal; Female; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates; Phytotherapy; Treatment Outcome | 2012 |
Emtricitabine-tenofovir concentrations and pre-exposure prophylaxis efficacy in men who have sex with men.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Tenofovir | 2012 |
Neurocognitive impairment in patients randomized to second-line lopinavir/ritonavir-based antiretroviral therapy vs. lopinavir/ritonavir monotherapy.
Topics: Adenine; Adult; CD4 Lymphocyte Count; Cognition Disorders; Depression; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Viral Load | 2012 |
Effect of adherence as measured by MEMS, ritonavir boosting, and CYP3A5 genotype on atazanavir pharmacokinetics in treatment-naive HIV-infected patients.
Topics: Adenine; Adult; Aged; Alleles; Atazanavir Sulfate; Cytochrome P-450 CYP3A; Deoxycytidine; Drug Interactions; Drug Therapy, Combination; Emtricitabine; Female; Genotype; HIV Infections; HIV Protease Inhibitors; Humans; Male; Medication Adherence; Middle Aged; Models, Biological; Nonlinear Dynamics; Oligopeptides; Organophosphonates; Pharmacogenetics; Pyridines; Ritonavir; Tenofovir; Young Adult | 2012 |
The early effects of stavudine compared with tenofovir on adipocyte gene expression, mitochondrial DNA copy number and metabolic parameters in South African HIV-infected patients: a randomized trial.
Topics: Adenine; Adipocytes; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; DNA Copy Number Variations; DNA, Mitochondrial; Dose-Response Relationship, Drug; Female; Gene Expression Profiling; Glucose; HIV Infections; Humans; Inflammation; Lipid Metabolism; Male; Middle Aged; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; South Africa; Stavudine; Tenofovir | 2013 |
Efavirenz, tenofovir and emtricitabine combined with first-line tuberculosis treatment in tuberculosis-HIV-coinfected Tanzanian patients: a pharmacokinetic and safety study.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antitubercular Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Ethambutol; Female; HIV Infections; Humans; Isoniazid; Male; Organophosphonates; Oxazines; Pyrazinamide; Reverse Transcriptase Inhibitors; Rifampin; Treatment Outcome; Tuberculosis, Pulmonary | 2013 |
Pharmacokinetic modelling of efavirenz, atazanavir, lamivudine and tenofovir in the female genital tract of HIV-infected pre-menopausal women.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Female; Genitalia, Female; HIV Infections; Humans; Lamivudine; Models, Biological; Oligopeptides; Organophosphonates; Premenopause; Pyridines; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Adherence and acceptability in MTN 001: a randomized cross-over trial of daily oral and topical tenofovir for HIV prevention in women.
Topics: Adenine; Administration, Oral; Administration, Topical; Adolescent; Adult; Anti-HIV Agents; Cross-Over Studies; Female; HIV Infections; Humans; Medication Adherence; Middle Aged; Organophosphonates; Patient Acceptance of Health Care; Patient Preference; Sexual Partners; South Africa; Tenofovir; Uganda; United States; Vaginal Creams, Foams, and Jellies | 2013 |
Randomized trial of lamivudine, adefovir, and the combination in HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors | 2012 |
A randomized comparison of second-line lopinavir/ritonavir monotherapy versus tenofovir/lamivudine/lopinavir/ritonavir in patients failing NNRTI regimens: the HIV STAR study.
Topics: Adenine; Adult; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Ritonavir; Tenofovir | 2012 |
Comparison of the antiviral effects of entecavir and adefovir dipivoxil in chronic HBV infection: a randomized control trial.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Bilirubin; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Virus Replication; Young Adult | 2012 |
Intensification of antiretroviral therapy through addition of enfuvirtide in naive HIV-1-infected patients with severe immunosuppression does not improve immunological response: results of a randomized multicenter trial (ANRS 130 Apollo).
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; Enfuvirtide; Female; HIV Envelope Protein gp41; HIV Infections; HIV-1; Humans; Immune Tolerance; Lopinavir; Male; Organophosphonates; Peptide Fragments; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2013 |
The pharmacokinetics, safety and efficacy of tenofovir and emtricitabine in HIV-1-infected pregnant women.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Europe; Female; Fetal Blood; HIV Infections; HIV-1; Humans; Infectious Disease Transmission, Vertical; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Tenofovir; Viral Load; Young Adult | 2013 |
Raltegravir pharmacokinetics in treatment-naive patients is not influenced by race: results from the raltegravir early therapy in African-Americans living with HIV (REAL) study.
Topics: Adenine; Adult; Black or African American; Body Mass Index; CD4 Lymphocyte Count; Deoxycytidine; Drug Administration Schedule; Emtricitabine; Female; HIV Infections; HIV Integrase; HIV Integrase Inhibitors; Humans; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Racial Groups; Raltegravir Potassium; Tenofovir; Viral Load; White People | 2013 |
Biphasic elimination of tenofovir diphosphate and nonlinear pharmacokinetics of zidovudine triphosphate in a microdosing study.
Topics: Adenine; Adult; Anti-HIV Agents; Biological Availability; Carbon Radioisotopes; CD4-Positive T-Lymphocytes; Dideoxynucleotides; Female; Humans; Male; Mass Spectrometry; Middle Aged; Organophosphonates; Phosphorylation; Reverse Transcriptase Inhibitors; Tenofovir; Thymine Nucleotides; Zidovudine | 2012 |
Maraviroc once-daily nucleoside analog-sparing regimen in treatment-naive patients: randomized, open-label pilot study.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Atazanavir Sulfate; CCR5 Receptor Antagonists; CD4 Lymphocyte Count; Cyclohexanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Fusion Inhibitors; HIV Infections; HIV-1; Humans; Male; Maraviroc; Middle Aged; Oligopeptides; Organophosphonates; Pilot Projects; Pyridines; Ritonavir; RNA, Viral; Tenofovir; Triazoles; Viral Load; Young Adult | 2013 |
Changes in fat mitochondrial DNA and function in subjects randomized to abacavir-lamivudine or tenofovir DF-emtricitabine with atazanavir-ritonavir or efavirenz: AIDS Clinical Trials Group study A5224s, substudy of A5202.
Topics: Adenine; Adipose Tissue; Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; DNA, Mitochondrial; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Lamivudine; Male; Mitochondria; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome | 2013 |
A 72-week randomized study of the safety and efficacy of a stavudine to zidovudine switch at 24 weeks compared to zidovudine or tenofovir disoproxil fumarate when given with lamivudine and nevirapine.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Diet; Drug Administration Schedule; Drug Substitution; Female; Glomerular Filtration Rate; Hemoglobins; HIV Infections; Humans; Lamivudine; Male; Nevirapine; Organophosphonates; Peripheral Nervous System Diseases; Stavudine; Tenofovir; Treatment Outcome; Viral Load; Zidovudine | 2012 |
Sustained efficacy of adefovir add-on therapy in chronic hepatitis B patient with a poor virological response to peginterferon alfa.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Treatment Outcome; Viral Load | 2013 |
Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study.
Topics: Adenine; Adult; Biopsy, Needle; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunohistochemistry; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Safety Management; Severity of Illness Index; Tenofovir; Time Factors; Treatment Outcome | 2013 |
Augmentation of hepatitis B virus-specific cellular immunity with programmed death receptor-1/programmed death receptor-L1 blockade in hepatitis B virus and HIV/hepatitis B virus coinfected patients treated with adefovir.
Topics: Adenine; Adult; Antiviral Agents; B7-H1 Antigen; CD8-Positive T-Lymphocytes; Double-Blind Method; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Immunity, Cellular; Male; Middle Aged; Organophosphonates; Programmed Cell Death 1 Receptor; Prospective Studies; T-Lymphocytes, Regulatory; Viral Load; Viremia | 2013 |
Pharmacokinetic properties of single-dose lamivudine/adefovir dipivoxil fixed-dose combination in healthy Chinese male volunteers.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Area Under Curve; Asian People; Biological Availability; Capsules; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Half-Life; Hong Kong; Humans; Lamivudine; Male; Metabolic Clearance Rate; Organophosphonates; Tablets; Therapeutic Equivalency; Young Adult | 2013 |
Pharmacokinetics and food interaction of a novel prodrug of tenofovir, tenofovir dipivoxil fumarate, in healthy volunteers.
Topics: Adenine; Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Eating; Fasting; Female; Food-Drug Interactions; Humans; Male; Organophosphonates; Phosphorous Acids; Prodrugs; Tenofovir | 2013 |
[Efficacy of combination therapy of lamivudine and adefovir dipivoxyl for patients with hepatitis B-induced decompensated liver cirrhosis].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; End Stage Liver Disease; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates | 2012 |
Adding adefovir vs. switching to entecavir for lamivudine-resistant chronic hepatitis B (ACE study): a 2-year follow-up randomized controlled trial.
Topics: Adenine; Adult; Analysis of Variance; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B, Chronic; Humans; Immunoassay; Lamivudine; Male; Middle Aged; Oligonucleotides; Organophosphonates; Prospective Studies; Republic of Korea; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Treatment Outcome | 2013 |
Impact of switching from zidovudine/lamivudine to tenofovir/emtricitabine on lipoatrophy: the RECOMB study.
Topics: Absorptiometry, Photon; Adenine; Adipose Tissue; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2013 |
Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic hepatitis B virus infected patients.
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B, Chronic; Humans; Killer Cells, Natural; Male; Middle Aged; NK Cell Lectin-Like Receptor Subfamily C; Organophosphonates; Phosphorous Acids; Receptors, KIR2DL3 | 2012 |
A novel breath test to directly measure use of vaginal gel and condoms.
Topics: Acetates; Adenine; Administration, Intravaginal; Adult; Anti-HIV Agents; Breath Tests; Butanones; Chromatography, Gas; Condoms; Female; Humans; Middle Aged; Organophosphonates; Pentanols; San Francisco; Tenofovir; Vaginal Creams, Foams, and Jellies; Young Adult | 2013 |
Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Drug Tolerance; Female; Genotype; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Phenotype; Phosphorus; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2012 |
Efficacy and safety of lersivirine (UK-453,061) versus efavirenz in antiretroviral treatment-naive HIV-1-infected patients: week 48 primary analysis results from an ongoing, multicenter, randomized, double-blind, phase IIb trial.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Intention to Treat Analysis; Male; Middle Aged; Mutation; Nitriles; Organophosphonates; Pyrazoles; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Young Adult | 2013 |
A randomized, double-blind comparison of coformulated elvitegravir/cobicistat/emtricitabine/tenofovir DF vs ritonavir-boosted atazanavir plus coformulated emtricitabine and tenofovir DF for initial treatment of HIV-1 infection: analysis of week 96 results
Topics: Adenine; Adult; Alanine Transaminase; Anti-HIV Agents; Aspartate Aminotransferases; Atazanavir Sulfate; Bilirubin; Bone Density; Carbamates; Cobicistat; Confidence Intervals; Creatinine; Deoxycytidine; Double-Blind Method; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Quinolones; Ritonavir; RNA, Viral; Tenofovir; Thiazoles; Triglycerides | 2013 |
Early versus delayed antiretroviral therapy and cerebrospinal fluid fungal clearance in adults with HIV and cryptococcal meningitis.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Alkynes; Amphotericin B; Anti-HIV Agents; Antifungal Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Colony Count, Microbial; Cyclopropanes; Deoxycytidine; Emtricitabine; Female; Humans; Immune Reconstitution Inflammatory Syndrome; Male; Meningitis, Cryptococcal; Organophosphonates; Survival Analysis; Tenofovir; Treatment Outcome | 2013 |
SWIFT: prospective 48-week study to evaluate efficacy and safety of switching to emtricitabine/tenofovir from lamivudine/abacavir in virologically suppressed HIV-1 infected patients on a boosted protease inhibitor containing antiretroviral regimen.
Topics: Adenine; Adult; Aged; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Biomarkers; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV Infections; Humans; Kaplan-Meier Estimate; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Protease Inhibitors; Proteinuria; Risk; Tenofovir | 2013 |
Efficacy of tenofovir disoproxil fumarate at 240 weeks in patients with chronic hepatitis B with high baseline viral load.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Phosphorous Acids; Treatment Outcome; Viral Load | 2013 |
MTN-001: randomized pharmacokinetic cross-over study comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other compartments.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Anti-HIV Agents; Cross-Over Studies; Female; HIV Infections; Humans; Middle Aged; Organophosphonates; Phosphorous Acids; Phosphorylation; Rectum; Tablets; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies; Young Adult | 2013 |
52-week efficacy and safety of telbivudine with conditional tenofovir intensification at week 24 in HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2013 |
A randomized double-blind comparison of coformulated elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate versus efavirenz/emtricitabine/tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: analysis of week 96 results.
Topics: Adenine; Adult; Anti-HIV Agents; Carbamates; Creatinine; Deoxycytidine; Double-Blind Method; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Oxazines; Quinolones; RNA, Viral; Thiazoles; Treatment Outcome; Young Adult | 2013 |
Pharmacokinetics of an increased atazanavir dose with and without tenofovir during the third trimester of pregnancy.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Atazanavir Sulfate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Oligopeptides; Organophosphonates; Postpartum Period; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Prospective Studies; Pyridines; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Young Adult | 2013 |
Feasibility of a breath test for monitoring adherence to vaginal administration of antiretroviral microbicide gels.
Topics: Acetates; Adenine; Administration, Cutaneous; Administration, Intravaginal; Adolescent; Adult; Anti-HIV Agents; Breath Tests; Drug Monitoring; Female; Humans; Middle Aged; Organophosphonates; Patient Compliance; Tenofovir; Vaginal Creams, Foams, and Jellies; Young Adult | 2013 |
[Efficacy and safety of telbivudine and adefovir dipivoxil for the treatment of chronic hepatitis B patients with high level hepatitis B virus load and hepatitis B e antigen-positivity].
Topics: Adenine; Adult; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2012 |
Durable efficacy and safety of raltegravir versus efavirenz when combined with tenofovir/emtricitabine in treatment-naive HIV-1-infected patients: final 5-year results from STARTMRK.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Oxazines; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2013 |
Impact of switching from zidovudine to tenofovir disoproxil fumarate on bone mineral density and markers of bone metabolism in virologically suppressed HIV-1 infected patients; a substudy of the PREPARE study.
Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; Bone and Bones; Bone Density; Cohort Studies; Down-Regulation; Drug Substitution; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Parathyroid Hormone; Tenofovir; Vitamin D; Zidovudine | 2013 |
Combination of lamivudine and adefovir without hepatitis B immune globulin is safe and effective prophylaxis against hepatitis B virus recurrence in hepatitis B surface antigen-positive liver transplant candidates.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biomarkers; Disease-Free Survival; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Kaplan-Meier Estimate; Lamivudine; Liver Transplantation; Male; Middle Aged; New South Wales; New Zealand; Organophosphonates; Prospective Studies; Risk Factors; Secondary Prevention; Time Factors; Treatment Outcome; Victoria; Viral Load; Young Adult | 2013 |
Randomized trial of emtricitabine/tenofovir disoproxil fumarate after hepatitis B immunoglobulin withdrawal after liver transplantation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B, Chronic; Humans; Immunoglobulins; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir; Treatment Outcome; United States | 2013 |
Efficacy and safety of telbivudine plus adefovir dipivoxil combination therapy and entecavir monotherapy for HBeAg-positive chronic hepatitis B patients with resistance to adefovir dipivoxil.
Topics: Adenine; Adult; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Prospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2013 |
Efficacy of telbivudine treatment for hepatitis B e antigen-positive chronic hepatitis B patients with poor response to adefovir dipivoxil.
Topics: Adenine; Adult; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome; Viral Load; Virus Replication | 2013 |
Adherence profiles and therapeutic responses of treatment-naive HIV-infected patients starting boosted atazanavir-based therapy in the ANRS 134-COPHAR 3 trial.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Deoxycytidine; Drug Administration Schedule; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Medication Adherence; Middle Aged; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Ritonavir; Surveys and Questionnaires; Tenofovir; Viral Load | 2013 |
Randomized trial of clinical safety of daily oral tenofovir disoproxil fumarate among HIV-uninfected men who have sex with men in the United States.
Topics: Adenine; Adolescent; Anti-HIV Agents; Boston; CD4 Lymphocyte Count; Double-Blind Method; Follow-Up Studies; Georgia; HIV Infections; HIV Seronegativity; Homosexuality, Male; Humans; Hypophosphatemia; Male; Medication Adherence; Middle Aged; Organophosphonates; San Francisco; Tenofovir; Treatment Outcome | 2013 |
Women with pregnancies had lower adherence to 1% tenofovir vaginal gel as HIV preexposure prophylaxis in CAPRISA 004, a phase IIB randomized-controlled trial.
Topics: Adenine; Adult; Anti-HIV Agents; Attitude to Health; Double-Blind Method; Female; HIV Infections; Humans; Medication Adherence; Multivariate Analysis; Odds Ratio; Organophosphonates; Pregnancy; South Africa; Tenofovir; Vaginal Creams, Foams, and Jellies; Young Adult | 2013 |
Neither microbial translocation nor TLR responsiveness are likely explanations for preexisting immune activation in women who subsequently acquired HIV in CAPRISA 004.
Topics: Adenine; Anti-HIV Agents; Bacterial Translocation; Cytokines; Fatty Acid-Binding Proteins; Female; HIV Infections; HIV-1; Humans; Killer Cells, Natural; Lipopolysaccharide Receptors; Lipopolysaccharides; Lymphocyte Activation; Organophosphonates; Tenofovir; Toll-Like Receptor 2; Toll-Like Receptor 4; Toll-Like Receptor 7; Toll-Like Receptor 8; Toll-Like Receptors | 2013 |
Sexual risk behavior among HIV-uninfected men who have sex with men participating in a tenofovir preexposure prophylaxis randomized trial in the United States.
Topics: Adenine; Adolescent; Adult; Amphetamine-Related Disorders; Anti-HIV Agents; Boston; Double-Blind Method; Follow-Up Studies; Georgia; Health Knowledge, Attitudes, Practice; HIV Infections; HIV Seronegativity; Homosexuality, Male; Humans; Male; Middle Aged; Organophosphonates; Risk Assessment; Risk-Taking; San Francisco; Sexual Partners; Tenofovir; Treatment Outcome; Unsafe Sex | 2013 |
Cobicistat versus ritonavir as a pharmacoenhancer of atazanavir plus emtricitabine/tenofovir disoproxil fumarate in treatment-naive HIV type 1-infected patients: week 48 results.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Cobicistat; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Thiazoles; Treatment Outcome; Viral Load | 2013 |
Two years efficiency of lamivudine and adefovir dipivoxil combined therapy in chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Prospective Studies | 2013 |
Abacavir/lamivudine versus tenofovir/emtricitabine with atazanavir/ritonavir for treatment-naive Japanese patients with HIV-1 infection: a randomized multicenter trial.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; Asian People; Atazanavir Sulfate; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Male; Oligopeptides; Organophosphonates; Pilot Projects; Pyridines; Ritonavir; Tenofovir; Treatment Outcome | 2013 |
Pharmacokinetic interactions between lersivirine and zidovudine, tenofovir disoproxil fumarate/emtricitabine and abacavir/lamivudine.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Interactions; Emtricitabine; Female; Healthy Volunteers; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Nitriles; Organophosphonates; Pyrazoles; Tenofovir; Young Adult; Zidovudine | 2013 |
A phase 1 randomized, double blind, placebo controlled rectal safety and acceptability study of tenofovir 1% gel (MTN-007).
Topics: Adenine; Administration, Rectal; Adult; Anti-HIV Agents; Double-Blind Method; Female; Gels; HIV Infections; Humans; Intestinal Mucosa; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Organophosphonates; Rectum; Tenofovir; Transcriptome; Young Adult | 2013 |
Antiviral efficacies of currently available rescue therapies for multidrug-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2013 |
Single dose pharmacokinetics of oral tenofovir in plasma, peripheral blood mononuclear cells, colonic tissue, and vaginal tissue.
Topics: Adenine; Administration, Oral; Adult; Anti-HIV Agents; Carbon Radioisotopes; Colon; Female; Humans; Isotope Labeling; Leukocytes, Mononuclear; Organophosphonates; Plasma; Tenofovir; Vagina | 2013 |
Intentions to use preexposure prophylaxis among current phase 2B preventive HIV-1 vaccine efficacy trial participants.
Topics: Adenine; Adolescent; Adult; AIDS Vaccines; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Heterosexuality; HIV Infections; Homosexuality, Male; Humans; Intention; Male; Middle Aged; Organophosphonates; Research Design; Surveys and Questionnaires; Tenofovir; Young Adult | 2013 |
Extended treatment with peginterferon α-2a in combination with lamivudine or adefovir for 96 weeks yields high rates of HBeAg and HBsAg seroconversion.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Young Adult | 2013 |
Long-term body composition and metabolic changes in HIV-infected children switched from stavudine to tenofovir and from protease inhibitors to efavirenz.
Topics: Absorptiometry, Photon; Adenine; Adolescent; Alkynes; Anti-Retroviral Agents; Benzoxazines; Blood Glucose; Body Composition; Child; Child, Preschool; Cohort Studies; Cyclopropanes; Female; HIV Infections; Humans; Lamivudine; Linear Models; Lipids; Longitudinal Studies; Male; Organophosphonates; Stavudine; Tenofovir | 2013 |
Early upper digestive tract side effects of zidovudine with tenofovir plus emtricitabine in West African adults with high CD4 counts.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cote d'Ivoire; Deoxycytidine; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Emtricitabine; Female; Gastrointestinal Diseases; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Zidovudine | 2013 |
Baseline hepatitis B surface antigen (HBsAg) as predictor of sustained HBsAg loss in chronic hepatitis B patients treated with pegylated interferon-α2a and adefovir.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biopsy; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Liver; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Viral Load; Young Adult | 2013 |
Randomized trial of the virologic response during up to two years of entecavir-adefovir combination therapy in multiple-drug-refractory chronic hepatitis B virus patients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2013 |
A randomized, comparative safety study of a prefilled plastic and user-filled paper applicator with candidate microbicide tenofovir 1% gel.
Topics: Adenine; Administration, Intravaginal; Adolescent; Adult; Anti-HIV Agents; Cross-Over Studies; Drug Delivery Systems; Female; HIV Infections; Humans; Middle Aged; Organophosphonates; Paper; Patient Acceptance of Health Care; Plastics; Tenofovir; Treatment Outcome; Vaginal Creams, Foams, and Jellies; Young Adult | 2013 |
Similar evolution of hepatitis B virus quasispecies in patients with incomplete adefovir response receiving tenofovir/emtricitabine combination or tenofovir monotherapy.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Evolution, Molecular; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Phylogeny; RNA-Directed DNA Polymerase; Tenofovir; Time Factors; Treatment Failure; Young Adult | 2013 |
Antiretroviral prophylaxis for HIV infection in injecting drug users in Bangkok, Thailand (the Bangkok Tenofovir Study): a randomised, double-blind, placebo-controlled phase 3 trial.
Topics: Adenine; Adult; Anti-HIV Agents; Double-Blind Method; Female; Follow-Up Studies; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Substance Abuse, Intravenous; Tenofovir; Thailand; Treatment Outcome; Young Adult | 2013 |
Three distinct phases of HIV-1 RNA decay in treatment-naive patients receiving raltegravir-based antiretroviral therapy: ACTG A5248.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Pilot Projects; Prospective Studies; Pyrrolidinones; Raltegravir Potassium; Ritonavir; RNA Stability; RNA, Viral; Tenofovir; Viral Load | 2013 |
Efficacy of combined therapy in patients with hepatitis B virus-related decompensated cirrhosis.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Chi-Square Distribution; China; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Kaplan-Meier Estimate; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2013 |
Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults.
Topics: Adenine; Adult; Alanine; Anti-Retroviral Agents; Area Under Curve; Dose-Response Relationship, Drug; Fatigue; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nausea; Organophosphates; Organophosphonates; RNA, Viral; Single-Blind Method; Statistics, Nonparametric; Tenofovir; Viral Load; Young Adult | 2013 |
Impact of a tenofovir disoproxil fumarate plus ritonavir-boosted protease inhibitor-based regimen on renal function in HIV-infected individuals: a prospective, multicenter study.
Topics: Adenine; Adult; Anti-HIV Agents; Creatinine; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Organophosphonates; Prospective Studies; Protease Inhibitors; Proteinuria; Ritonavir; Statistics, Nonparametric; Tenofovir | 2013 |
Safety of coitally administered tenofovir 1% gel, a vaginal microbicide, in chronic hepatitis B virus carriers: results from the CAPRISA 004 trial.
Topics: Adenine; Adult; Anti-Infective Agents, Local; Antiviral Agents; Carrier State; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Vaginal Creams, Foams, and Jellies | 2013 |
Impact on L-carnitine Homeostasis of Short-term Treatment with the Pivalate Prodrug Tenofovir Dipivoxil.
Topics: Adenine; Adult; Antiviral Agents; Carnitine; Dose-Response Relationship, Drug; Female; Hepatitis B; Herpes Simplex; Homeostasis; Humans; Male; Organophosphonates; Prodrugs; Tenofovir | 2013 |
Telbivudine and adefovir combination therapy for patients with chronic lamivudine-resistant hepatitis B virus infections.
Topics: Adenine; Adult; Aged; Antibodies, Viral; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome | 2014 |
Variability of raltegravir plasma levels in the clinical setting.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; HIV Infections; Humans; Lamivudine; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Tenofovir | 2013 |
96-Week results of abacavir/lamivudine versus tenofovir/emtricitabine, plus efavirenz, in antiretroviral-naive, HIV-1-infected adults: ASSERT study.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Bone and Bones; Bone Density; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Kidney; Lamivudine; Male; Organophosphonates; Tenofovir; Time Factors; Treatment Outcome | 2013 |
Switching tenofovir/emtricitabine plus lopinavir/r to raltegravir plus Darunavir/r in patients with suppressed viral load did not result in improvement of renal function but could sustain viral suppression: a randomized multicenter trial.
Topics: Adenine; Adult; Anti-HIV Agents; Darunavir; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Kidney; Kidney Function Tests; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Sulfonamides; Tenofovir; Viral Load | 2013 |
Assessment of pharmacokinetic interactions of the HCV NS5A replication complex inhibitor daclatasvir with antiretroviral agents: ritonavir-boosted atazanavir, efavirenz and tenofovir.
Topics: Adenine; Adolescent; Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Carbamates; Coinfection; Cyclopropanes; Drug Interactions; Female; Hepatitis C; HIV Infections; Humans; Imidazoles; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Pyrrolidines; Ritonavir; Tenofovir; Valine; Viral Nonstructural Proteins; Young Adult | 2013 |
[Clinical efficacy of various antiviral-based strategies to treat chronic hepatitis patients with positivity for hepatitis B e antigen and rtN236T mutation].
Topics: Adenine; Adult; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Young Adult | 2013 |
Evaluation of four tenofovir-containing regimens as first-line treatments in Cameroon and Senegal: the ANRS 12115 DAYANA Trial.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cameroon; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; HIV Infections; HIV-1; Humans; Male; Medication Adherence; Middle Aged; Organophosphonates; Senegal; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2014 |
Pharmacokinetics and safety of tenofovir in HIV-infected women during labor and their infants during the first week of life.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Drug Administration Schedule; Female; Fetal Blood; HIV Infections; Humans; Infant, Newborn; Labor, Obstetric; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir; Young Adult | 2014 |
Association of higher plasma vitamin D binding protein and lower free calcitriol levels with tenofovir disoproxil fumarate use and plasma and intracellular tenofovir pharmacokinetics: cause of a functional vitamin D deficiency?
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Calcitriol; Calcium; Double-Blind Method; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glomerular Filtration Rate; HIV; HIV Infections; Humans; Hypophosphatemia; Male; Organophosphonates; Parathyroid Hormone; Phosphates; Reverse Transcriptase Inhibitors; Tenofovir; Vitamin D Deficiency; Vitamin D-Binding Protein | 2013 |
Raltegravir-emtricitabine-tenofovir as HIV nonoccupational post-exposure prophylaxis in men who have sex with men: safety, tolerability and adherence.
Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; Creatine Kinase; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Medication Adherence; Organophosphonates; Prospective Studies; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Tenofovir | 2014 |
Adherence to antiretroviral prophylaxis for HIV prevention: a substudy cohort within a clinical trial of serodiscordant couples in East Africa.
Topics: Adenine; Adult; Africa, Eastern; Anti-HIV Agents; Cohort Studies; Deoxycytidine; Emtricitabine; Family Characteristics; Female; HIV Infections; HIV Seropositivity; Humans; Male; Medication Adherence; Multivariate Analysis; Organophosphonates; Regression Analysis; Tenofovir | 2013 |
Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial.
Topics: Adenine; Adult; CD4 Lymphocyte Count; Dideoxynucleosides; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV Integrase Inhibitors; HIV-1; Humans; Kaplan-Meier Estimate; Lamivudine; Male; Organophosphonates; Oxazines; Piperazines; Pyridones; Pyrrolidinones; Raltegravir Potassium; RNA, Viral; Tenofovir | 2013 |
[Efficacy and safety of peginterferon alfa-2a (40 kd) plus adefovir for 96 weeks in HBeAg-negative chronic hepatitis B patients].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome | 2013 |
Antiviral treatment improves disrupted peripheral B lymphocyte homeostasis in chronic hepatitis B virus-infected patients.
Topics: Adenine; Adult; Antiviral Agents; B-Lymphocytes; Female; Flow Cytometry; Hepatitis B, Chronic; Homeostasis; Humans; Liver Diseases; Male; Organophosphonates; Tenofovir; Viral Load; Virus Replication | 2013 |
Safety, adherence and acceptability of intermittent tenofovir/emtricitabine as HIV pre-exposure prophylaxis (PrEP) among HIV-uninfected Ugandan volunteers living in HIV-serodiscordant relationships: a randomized, clinical trial.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Male; Organophosphonates; Patient Compliance; Tenofovir; Uganda | 2013 |
Participant experiences and facilitators and barriers to pill use among men who have sex with men in the iPrEx pre-exposure prophylaxis trial in San Francisco.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antiviral Agents; Deoxycytidine; Double-Blind Method; Emtricitabine; Focus Groups; Health Knowledge, Attitudes, Practice; HIV Infections; HIV-1; Homosexuality, Male; Humans; Interviews as Topic; Male; Medication Adherence; Middle Aged; Organophosphonates; Qualitative Research; Risk Factors; San Francisco; Tenofovir; Young Adult | 2013 |
De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis.
Topics: Adenine; Adult; Alanine Transaminase; Analysis of Variance; Antiviral Agents; Biomarkers; Chi-Square Distribution; China; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Prospective Studies; Time Factors; Treatment Outcome | 2013 |
Effect of food on rilpivirine/emtricitabine/tenofovir disoproxil fumarate, an antiretroviral single-tablet regimen for the treatment of HIV infection.
Topics: Adenine; Adult; Anti-HIV Agents; Cross-Over Studies; Deoxycytidine; Drug Combinations; Emtricitabine; Fasting; Female; Food-Drug Interactions; HIV Infections; Humans; Male; Middle Aged; Nitriles; Organophosphonates; Pyrimidines; Rilpivirine; Tablets; Tenofovir; Young Adult | 2014 |
Pharmacokinetics and tolerability of Tenofovir disoproxil fumarate 300 mg once daily: an open-label, single- and multiple-dose study in healthy Chinese subjects.
Topics: Adenine; Administration, Oral; Adult; Anti-Retroviral Agents; Asian People; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Young Adult | 2013 |
De novo combination therapy adefovir plus lamivudine as a treatment for women of child-bearing age with HBeAg-positive chronic hepatitis B before pregnancy.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Disease Transmission, Infectious; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2014 |
Add-on peg-interferon leads to loss of HBsAg in patients with HBeAg-negative chronic hepatitis and HBV DNA fully suppressed by long-term nucleotide analogs.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins | 2013 |
Estimation of tenofovir's population pharmacokinetic parameters without reliable dosing histories and application to tracing dosing history using simulation strategies.
Topics: Adenine; Administration, Intravaginal; Administration, Oral; Adolescent; Adult; Anti-HIV Agents; Computer Simulation; Drug Therapy, Combination; Female; Humans; Middle Aged; Models, Biological; Organophosphonates; Patient Compliance; Tenofovir; Young Adult | 2014 |
Population pharmacokinetics of adefovir dipivoxil tablets in healthy Chinese volunteers.
Topics: Adenine; Adult; Antiviral Agents; Female; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Models, Biological; Organophosphonates; Tablets | 2014 |
Experimental HBsAg/anti-HBs complex assay for prediction of HBeAg loss in chronic hepatitis B patients treated with pegylated interferon and adefovir.
Topics: Adenine; Adult; Antigen-Antibody Complex; Antiviral Agents; Area Under Curve; DNA, Viral; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Predictive Value of Tests; Protein Array Analysis; Protein Binding; Recombinant Proteins; Treatment Outcome | 2014 |
Effects of switching from efavirenz to raltegravir on endothelial function, bone mineral metabolism, inflammation, and renal function: a randomized, controlled trial.
Topics: Adenine; Adult; Alkaline Phosphatase; Anti-HIV Agents; Biomarkers; Bone and Bones; C-Reactive Protein; Cholesterol; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Endothelium, Vascular; Female; HIV Infections; Humans; Indiana; Inflammation; Male; Organophosphonates; Oxazines; Pyrrolidinones; Raltegravir Potassium; Renal Insufficiency; Treatment Outcome; Viral Load | 2013 |
Long-term efficacy and safety of emtricitabine plus tenofovir DF vs. tenofovir DF monotherapy in adefovir-experienced chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B Antibodies; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome; Viral Load; Viremia | 2014 |
Low body weight in females is a risk factor for increased tenofovir exposure and drug-related adverse events.
Topics: Adenine; Adult; Anti-HIV Agents; Body Weight; Bone Resorption; Female; HIV Infections; Humans; Middle Aged; Organophosphonates; Risk Factors; Tenofovir | 2013 |
Maintaining remission in lamivudine-resistant patients with a virological response to adefovir add-on lamivudine after stopping lamivudine therapy.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Organophosphonates; Polymerase Chain Reaction; Treatment Outcome; Ultrasonography; Viral Load | 2014 |
Dynamics of immune reconstitution and activation markers in HIV+ treatment-naïve patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine.
Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lymphocyte Activation; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Young Adult | 2013 |
Randomized comparison of tenofovir disoproxil fumarate vs emtricitabine and tenofovir disoproxil fumarate in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Europe; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; New Zealand; North America; Organophosphonates; Prospective Studies; Tenofovir; Time Factors; Treatment Outcome; Viral Load | 2014 |
[Therapeutic effect of antiviral regimens for chronic hepatitis B refractory to lamivudine plus adefovir].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Mutation; Organophosphonates; Real-Time Polymerase Chain Reaction; Recombinant Proteins | 2013 |
Limited HIV-1 superinfection in seroconverters from the CAPRISA 004 Microbicide Trial.
Topics: Adenine; Adult; Anti-Infective Agents; Chemoprevention; env Gene Products, Human Immunodeficiency Virus; Female; gag Gene Products, Human Immunodeficiency Virus; HIV Infections; HIV-1; Humans; Incidence; Kenya; Organophosphonates; Sequence Analysis, DNA; South Africa; Superinfection; Tenofovir; Vaginal Creams, Foams, and Jellies; Viral Load; Young Adult | 2014 |
The 104-week efficacy and safety of telbivudine-based optimization strategy in chronic hepatitis B patients: a randomized, controlled study.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; China; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Telbivudine; Thymidine; Time Factors; Treatment Outcome; Young Adult | 2014 |
Efficacy of preexposure prophylaxis for HIV-1 prevention among high-risk heterosexuals: subgroup analyses from a randomized trial.
Topics: Adenine; Adult; Anti-Retroviral Agents; Chemoprevention; Deoxycytidine; Emtricitabine; Female; Heterosexuality; HIV Infections; HIV-1; Humans; Incidence; Kenya; Male; Organophosphonates; Placebos; Tenofovir; Treatment Outcome; Uganda | 2013 |
Strong relationship between oral dose and tenofovir hair levels in a randomized trial: hair as a potential adherence measure for pre-exposure prophylaxis (PrEP).
Topics: Adenine; Administration, Oral; Adult; Demography; Dose-Response Relationship, Drug; Female; Hair; HIV Infections; Humans; Male; Medication Adherence; Organophosphonates; Tenofovir | 2014 |
Efficacy of switching to telbivudine plus adefovir in suboptimal responders to lamivudine plus adefovir.
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Biomarkers; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Substitution; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Patient Selection; Prospective Studies; Republic of Korea; Telbivudine; Thymidine; Time Factors; Treatment Failure; Viral Load; Young Adult | 2013 |
Sensitive tenofovir resistance screening of HIV-1 from the genital and blood compartments of women with breakthrough infections in the CAPRISA 004 tenofovir gel trial.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Drug Resistance, Viral; Female; Gels; HIV Infections; HIV-1; Humans; Organophosphonates; Polymerase Chain Reaction; South Africa; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies; Viral Load; Young Adult | 2014 |
Renal events among women treated with tenofovir/emtricitabine in combination with either lopinavir/ritonavir or nevirapine.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Kidney Diseases; Lopinavir; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome | 2014 |
HIV-1 genital shedding in HIV-infected patients randomized to second-line lopinavir/ritonavir monotherapy versus tenofovir/lamivudine/lopinavir/ritonavir.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Follow-Up Studies; Genitalia; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Male; Organophosphonates; Risk Factors; Ritonavir; Tenofovir; Time Factors; Treatment Outcome; Viral Load; Virus Shedding | 2014 |
Changes in renal function associated with oral emtricitabine/tenofovir disoproxil fumarate use for HIV pre-exposure prophylaxis.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Chemoprevention; Creatinine; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Kidney; Kidney Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Organophosphonates; Phosphorus; Placebos; Tenofovir; Young Adult | 2014 |
Vitamin D3 supplementation increases fibroblast growth factor-23 in HIV-infected youths treated with tenofovir disoproxil fumarate.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Cholecalciferol; Dietary Supplements; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; HIV Infections; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Young Adult | 2014 |
Comparison of body composition changes between atazanavir/ritonavir and lopinavir/ritonavir each in combination with tenofovir/emtricitabine in antiretroviral-naïve patients with HIV-1 infection.
Topics: Absorptiometry, Photon; Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Body Composition; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Lopinavir; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Tomography, X-Ray Computed; Young Adult | 2014 |
Cardiovascular disease risk factors in HIV-infected women after initiation of lopinavir/ritonavir- and nevirapine-based antiretroviral therapy in Sub-Saharan Africa: A5208 (OCTANE).
Topics: Adenine; Adult; Africa South of the Sahara; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Pressure; Body Mass Index; Cardiovascular Diseases; CD4-Positive T-Lymphocytes; Cholesterol, HDL; Cholesterol, LDL; Deoxycytidine; Emtricitabine; Endpoint Determination; Female; HIV Infections; HIV-1; Humans; Linear Models; Logistic Models; Lopinavir; Multivariate Analysis; Nevirapine; Organophosphonates; Prospective Studies; Risk Factors; Ritonavir; RNA, Viral; Tenofovir; Triglycerides | 2014 |
Efficacy and safety of tenofovir disoproxil fumarate in Asian-Americans with chronic hepatitis B in community settings.
Topics: Adenine; Adolescent; Adult; Asian; Creatinine; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Residence Characteristics; Tenofovir; Treatment Outcome; Young Adult | 2014 |
Effects of a protein-rich drink or a standard meal on the pharmacokinetics of elvitegravir, cobicistat, emtricitabine and tenofovir in healthy Japanese male subjects: a randomized, three-way crossover study.
Topics: Adenine; Adult; Anti-HIV Agents; Asian People; Beverages; Carbamates; Cobicistat; Cross-Over Studies; Deoxycytidine; Dietary Proteins; Drug Combinations; Emtricitabine; Food-Drug Interactions; Humans; Male; Middle Aged; Organophosphonates; Quinolones; Tenofovir; Thiazoles; Young Adult | 2014 |
Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice.
Topics: Adenine; Adult; Animals; Antibody Formation; Antiviral Agents; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Middle Aged; Organophosphonates; T-Lymphocytes; Vaccines, DNA; Young Adult | 2015 |
Measuring adherence by visual inspection of returned empty gel applicators in the CAPRISA 004 microbicide trial.
Topics: Adenine; Administration, Intravaginal; Adult; Anti-Infective Agents; Coitus; Double-Blind Method; Drug Delivery Systems; Female; Follow-Up Studies; Gels; HIV Infections; Humans; Multivariate Analysis; Organophosphonates; Patient Compliance; Proportional Hazards Models; Rural Population; South Africa; Tenofovir; Urban Population | 2014 |
Entecavir 1mg versus combined lamivudine/adefovir dipivoxil in chronic HBV Egyptian patients resistant to LAM monotherapy, non-randomised controlled study.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Egypt; Female; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2014 |
Phenotypic and genotypic analyses to guide selection of reverse transcriptase inhibitors in second-line HIV therapy following extended virological failure in Uganda.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Organophosphonates; Tenofovir; Uganda; Zidovudine | 2014 |
Impact of an adherence intervention on the effectiveness of tenofovir gel in the CAPRISA 004 trial.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Infective Agents, Local; Double-Blind Method; Female; Gels; Health Behavior; HIV Infections; Humans; Incidence; Medication Adherence; Models, Psychological; Motivational Interviewing; Organophosphonates; Socioeconomic Factors; South Africa; Tenofovir; Treatment Outcome | 2014 |
Curative effect of combined lamivudine, adefovir dipivoxil, and stem cell transplantation on decompensated hepatitis B cirrhosis.
Topics: Adenine; alpha-Fetoproteins; Cholinesterases; Combined Modality Therapy; Female; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Organophosphonates; Prothrombin Time; Stem Cell Transplantation | 2014 |
Adherence in the CAPRISA 004 tenofovir gel microbicide trial.
Topics: Adenine; Administration, Intravaginal; Adult; Anti-HIV Agents; Anti-Infective Agents, Local; Counseling; Double-Blind Method; Female; Follow-Up Studies; Gels; HIV Infections; HIV-1; Humans; Incidence; Kaplan-Meier Estimate; Medication Adherence; Motivational Interviewing; Organophosphonates; Rural Population; Sexual Behavior; Socioeconomic Factors; South Africa; Tenofovir; Treatment Outcome; Urban Population | 2014 |
Rilpivirine versus efavirenz with emtricitabine/tenofovir disoproxil fumarate in treatment-naïve HIV-1-infected patients with HIV-1 RNA ≤100,000 copies/mL: week 96 pooled ECHO/THRIVE subanalysis.
Topics: Adenine; Adolescent; Adult; Aged; Alkynes; Anti-HIV Agents; Antiviral Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nitriles; Organophosphonates; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; RNA, Viral; Tenofovir; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2014 |
Risk behaviors and risk factors for HIV infection among participants in the Bangkok tenofovir study, an HIV pre-exposure prophylaxis trial among people who inject drugs.
Topics: Adenine; Adult; Anti-HIV Agents; Double-Blind Method; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Risk-Taking; Substance-Related Disorders; Tenofovir; Thailand | 2014 |
HLA alleles association with changes in bone mineral density in HIV-1-infected adults changing treatment to tenofovir-emtricitabine or abacavir-lamivudine.
Topics: Adenine; Adult; Alleles; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Density; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; HLA-DQ Antigens; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir | 2014 |
Normal laboratory reference intervals among healthy adults screened for a HIV pre-exposure prophylaxis clinical trial in Botswana.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Botswana; Deoxycytidine; Emtricitabine; Female; Hematologic Tests; HIV Infections; Humans; Male; Organophosphonates; Reference Values; Tenofovir; Young Adult | 2014 |
Hip structural parameters over 96 weeks in HIV-infected adults switching treatment to tenofovir-emtricitabine or abacavir-lamivudine.
Topics: Adenine; Anti-HIV Agents; Bone Density; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Substitution; Emtricitabine; Female; Hip Joint; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Radiography; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2014 |
Raltegravir for the treatment of patients co-infected with HIV and tuberculosis (ANRS 12 180 Reflate TB): a multicentre, phase 2, non-comparative, open-label, randomised trial.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Alkynes; Anti-HIV Agents; Antitubercular Agents; Benzoxazines; Brazil; Coinfection; Cyclopropanes; Drug Therapy, Combination; Female; France; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; RNA, Viral; Tenofovir; Treatment Outcome; Tuberculosis; Viral Load | 2014 |
Non-interventional study AI463-12 of real-world chronic HBV infection management--baseline characteristics and treatment patterns of Polish patients kohort.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; Europe; Female; Guanine; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Poland; Practice Guidelines as Topic; Retrospective Studies; Socioeconomic Factors; Treatment Outcome | 2013 |
Inhibitory effects of p-aminohippurate and probenecid on the renal clearance of adefovir and benzylpenicillin as probe drugs for organic anion transporter (OAT) 1 and OAT3 in humans.
Topics: Adenine; Adult; Drug Interactions; HEK293 Cells; Humans; In Vitro Techniques; Kidney; Male; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; p-Aminohippuric Acid; Penicillin G; Probenecid; Young Adult | 2014 |
Persistent viremia in human immunodeficiency virus/hepatitis B coinfected patients undergoing long-term tenofovir: virological and clinical implications.
Topics: Adenine; Adult; Coinfection; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load; Viremia; Virus Replication | 2014 |
Combination antiretroviral treatment for women previously treated only in pregnancy: week 24 results of AIDS clinical trials group protocol a5227.
Topics: Adenine; Adult; Alkynes; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Pregnancy; Prospective Studies; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2014 |
HIV protective efficacy and correlates of tenofovir blood concentrations in a clinical trial of PrEP for HIV prevention.
Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; Cohort Studies; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Seropositivity; Humans; Male; Medication Adherence; Organophosphonates; Predictive Value of Tests; Proportional Hazards Models; Tenofovir; Young Adult | 2014 |
Identification of serum cytokine profiles associated with HBeAg seroconversion following antiviral treatment interruption.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; Cytokines; Female; Hepatitis B e Antigens; Hepatitis C, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Placebos; Serum; T-Lymphocytes; Withholding Treatment; Young Adult | 2014 |
A 48-week study of fat molecular alterations in HIV naive patients starting tenofovir/emtricitabine with lopinavir/ritonavir or efavirenz.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Gene Expression Regulation; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lopinavir; Organophosphonates; Ritonavir; Subcutaneous Fat; Tenofovir; Transcriptome | 2014 |
[Long-term efficacy and safety of telbivudine as monotherapy and as combination therapy with adefovir dipivoxil in HBeAg-positive chronic hepatitis B patients].
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Young Adult | 2014 |
Role of a 48-week pegylated interferon therapy in hepatitis B e antigen positive HIV-co-infected patients on cART including tenofovir: EMVIPEG study.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; Coinfection; Deoxycytidine; Drug Carriers; Emtricitabine; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir; Treatment Outcome; Viral Load | 2014 |
Use of tenofovir disoproxil fumarate in highly viremic, hepatitis B mono-infected pregnant women.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Odds Ratio; Organophosphonates; Pregnancy; Risk Factors; Tenofovir; Viremia; Young Adult | 2014 |
First-line monotherapies of tenofovir and entecavir have comparable efficacies in hepatitis B treatment.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Cohort Studies; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Young Adult | 2014 |
Kinetics and prediction of HBsAg loss during long-term therapy with nucleos(t)ide analogues of different potency in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates | 2014 |
Switching to coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus continuation of non-nucleoside reverse transcriptase inhibitor with emtricitabine and tenofovir in virologically suppressed adults with HIV (STRATEGY-NNRTI): 48 week r
Topics: Adenine; Adult; Anti-HIV Agents; Carbamates; Cobicistat; Deoxycytidine; Emtricitabine; Female; HIV; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Quinolones; Reverse Transcriptase Inhibitors; Tenofovir; Thiazoles; Viral Load | 2014 |
Simplification to coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus continuation of ritonavir-boosted protease inhibitor with emtricitabine and tenofovir in adults with virologically suppressed HIV (STRATEGY-PI): 48 week results o
Topics: Adenine; Adult; Anti-HIV Agents; Carbamates; Cobicistat; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Protease Inhibitors; Quinolones; Ritonavir; Tenofovir; Thiazoles; Viral Load | 2014 |
Syphilis predicts HIV incidence among men and transgender women who have sex with men in a preexposure prophylaxis trial.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; Homosexuality, Male; Humans; Incidence; Male; Middle Aged; Organophosphonates; Placebos; Pre-Exposure Prophylaxis; Prevalence; Syphilis; Tenofovir; Transgender Persons; Treatment Outcome; Young Adult | 2014 |
No resistance to tenofovir disoproxil fumarate through 96 weeks of treatment in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Point Mutation; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Tenofovir | 2014 |
Predictors of suboptimal CD4 response among women achieving virologic suppression in a randomized antiretroviral treatment trial, Africa.
Topics: Adenine; Adult; Africa; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lopinavir; Nevirapine; Organophosphonates; Ritonavir; Tenofovir; Treatment Outcome | 2014 |
Daily oral tenofovir and emtricitabine-tenofovir preexposure prophylaxis reduces herpes simplex virus type 2 acquisition among heterosexual HIV-1-uninfected men and women: a subgroup analysis of a randomized trial.
Topics: Adenine; Administration, Oral; Adult; Anti-Retroviral Agents; Antiviral Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Herpes Genitalis; Herpesvirus 2, Human; Heterosexuality; HIV Infections; HIV Seronegativity; HIV-1; Humans; Incidence; Male; Medication Adherence; Organophosphonates; RNA, Viral; Tenofovir | 2014 |
First-line antiretroviral therapy with nevirapine versus lopinavir-ritonavir based regimens in a resource-limited setting.
Topics: Adenine; Adult; CD4 Lymphocyte Count; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load; Zidovudine | 2014 |
Kinetics of hepatitis B surface antigen loss in patients with HBeAg-positive chronic hepatitis B treated with tenofovir disoproxil fumarate.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Double-Blind Method; Female; Genotype; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Regression Analysis; Retrospective Studies; Tenofovir; Time Factors; Treatment Outcome; Young Adult | 2014 |
Antiviral therapy improves postoperative survival in patients with hepatocellular carcinoma: a randomized controlled trial.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Hepatitis B; Hepatitis B, Chronic; Humans; Liver Failure; Liver Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Organophosphonates; Prospective Studies; Survival Analysis; Virus Activation; Young Adult | 2015 |
Clinical assessment of potential drug interactions of faldaprevir, a hepatitis C virus protease inhibitor, with darunavir/ritonavir, efavirenz, and tenofovir.
Topics: Adenine; Adult; Alkynes; Aminoisobutyric Acids; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Coinfection; Cyclopropanes; Darunavir; Drug Interactions; Female; Healthy Volunteers; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Leucine; Male; Middle Aged; Oligopeptides; Organophosphonates; Proline; Protease Inhibitors; Quinolines; Ritonavir; Sulfonamides; Tenofovir; Thiazoles; Young Adult | 2014 |
Accuracy of Self-Report and Pill-Count Measures of Adherence in the FEM-PrEP Clinical Trial: Implications for Future HIV-Prevention Trials.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; Humans; Interviews as Topic; Kenya; Male; Medication Adherence; Middle Aged; Organophosphonates; Pre-Exposure Prophylaxis; Predictive Value of Tests; Qualitative Research; Self Report; Tenofovir; Treatment Outcome | 2015 |
Ritonavir-boosted darunavir combined with raltegravir or tenofovir-emtricitabine in antiretroviral-naive adults infected with HIV-1: 96 week results from the NEAT001/ANRS143 randomised non-inferiority trial.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cholesterol, HDL; Cholesterol, LDL; Darunavir; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Sulfonamides; Tenofovir; Treatment Outcome | 2014 |
Changes in proteinuria and albuminuria with initiation of antiretroviral therapy: data from a randomized trial comparing tenofovir disoproxil fumarate/emtricitabine versus abacavir/lamivudine.
Topics: Adenine; Adult; Albuminuria; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Linear Models; Male; Organophosphonates; Proteinuria; Tenofovir | 2014 |
High medication adherence during periconception periods among HIV-1-uninfected women participating in a clinical trial of antiretroviral pre-exposure prophylaxis.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Cohort Studies; Double-Blind Method; Female; Fertilization; HIV Infections; Humans; Kenya; Medication Adherence; Organophosphonates; Pre-Exposure Prophylaxis; Pregnancy; Pregnancy Complications, Infectious; Proportional Hazards Models; Regression Analysis; Tenofovir; Uganda; Young Adult | 2014 |
Improvement in bone mineral density after switching from tenofovir to abacavir in HIV-1-infected patients with low bone mineral density: two-centre randomized pilot study (OsteoTDF study).
Topics: Adenine; Adult; Anti-HIV Agents; Bone Density; Dideoxynucleosides; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Osteoporosis; Pilot Projects; Tenofovir; Treatment Outcome | 2014 |
Combination therapy with pegylated interferon alpha-2b and adefovir dipivoxil in HBeAg-positive chronic hepatitis B versus interferon alone: a prospective, randomized study.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins | 2014 |
Differential subcutaneous adipose tissue gene expression patterns in a randomized clinical trial of efavirenz or lopinavir-ritonavir in antiretroviral-naive patients.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adipogenesis; Adiponectin; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Body Composition; CCAAT-Enhancer-Binding Proteins; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; Energy Metabolism; Female; Gene Expression; Glucose; Glucose Transporter Type 4; HIV-1; Humans; Inflammation; Lipid Metabolism; Lipoprotein Lipase; Lopinavir; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; Subcutaneous Fat; Tenofovir | 2014 |
FEM-PrEP: adherence patterns and factors associated with adherence to a daily oral study product for pre-exposure prophylaxis.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Logistic Models; Male; Medication Adherence; Multivariate Analysis; Organophosphonates; Risk Factors; Tenofovir; Young Adult | 2014 |
The RADAR study: week 48 safety and efficacy of RAltegravir combined with boosted DARunavir compared to tenofovir/emtricitabine combined with boosted darunavir in antiretroviral-naive patients. Impact on bone health.
Topics: Adenine; Adult; Bone Density; Darunavir; Deoxycytidine; Emtricitabine; HIV Infections; HIV-1; Humans; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Sulfonamides; Tenofovir | 2014 |
Viral suppression and cirrhosis regression with tenofovir disoproxil fumarate in Asians with chronic hepatitis B.
Topics: Adenine; DNA, Viral; Double-Blind Method; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Intention to Treat Analysis; Liver Cirrhosis; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir | 2015 |
Tenofovir disoproxil fumarate vs adefovir dipivoxil in Chinese patients with chronic hepatitis B after 48 weeks: a randomized controlled trial.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Asian People; China; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2015 |
HIV disease progression in seroconvertors from the CAPRISA 004 tenofovir gel pre-exposure prophylaxis trial.
Topics: Adenine; Disease Progression; Female; Gels; HIV Infections; Humans; Organophosphonates; Placebos; Pre-Exposure Prophylaxis; Reverse Transcriptase Inhibitors; Tenofovir; Vagina | 2015 |
Pre-exposure prophylaxis does not affect the fertility of HIV-1-uninfected men.
Topics: Adenine; Adult; Anti-Retroviral Agents; Chemoprevention; Deoxycytidine; Emtricitabine; Female; Fertility; HIV Infections; Humans; Male; Organophosphonates; Placebos; Pre-Exposure Prophylaxis; Pregnancy; Tenofovir | 2014 |
Tenofovir disoproxil fumarate in Asian or Pacific Islander chronic hepatitis B patients with high viral load (≥ 9 log10 copies/ml).
Topics: Adenine; Adult; Asian People; Drug Resistance, Viral; Hepatitis B, Chronic; Humans; Native Hawaiian or Other Pacific Islander; Organophosphonates; Statistics, Nonparametric; Tenofovir; Viral Load | 2015 |
Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence trial.
Topics: Adenine; Adult; Atazanavir Sulfate; Darunavir; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; RNA, Viral; Sulfonamides; Tenofovir; Therapeutic Equivalency; Viral Load | 2014 |
Trial participation disclosure and gel use behavior in the CAPRISA 004 tenofovir gel trial.
Topics: Adenine; Administration, Intravaginal; Adult; Anti-HIV Agents; Disclosure; Female; Gels; HIV Infections; Humans; Male; Medication Adherence; Organophosphonates; Patient Acceptance of Health Care; Sexual Behavior; Sexual Partners; Tenofovir | 2014 |
Single-agent tenofovir versus combination emtricitabine plus tenofovir for pre-exposure prophylaxis for HIV-1 acquisition: an update of data from a randomised, double-blind, phase 3 trial.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Kenya; Male; Organophosphonates; Placebos; Pre-Exposure Prophylaxis; Tenofovir; Treatment Outcome; Uganda | 2014 |
A multi-compartment single and multiple dose pharmacokinetic comparison of rectally applied tenofovir 1% gel and oral tenofovir disoproxil fumarate.
Topics: Adenine; Administration, Oral; Administration, Rectal; Adult; Female; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Vaginal Creams, Foams, and Jellies | 2014 |
Randomized, three-arm study to optimize lamivudine efficacy in hepatitis B e antigen-positive chronic hepatitis B patients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Young Adult | 2015 |
Sino-implant (II)® continuation and effect of concomitant tenofovir disoproxil fumarate-emtricitabine use on plasma levonorgestrel concentrations among women in Bondo, Kenya.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Contraceptive Agents, Female; Deoxycytidine; Drug Combinations; Drug Implants; Emtricitabine; Female; HIV Infections; Humans; Kenya; Levonorgestrel; Longitudinal Studies; Organophosphonates; Polypharmacy; Prospective Studies; Tenofovir; Young Adult | 2015 |
Drug resistance and plasma viral RNA level after ineffective use of oral pre-exposure prophylaxis in women.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; High-Throughput Nucleotide Sequencing; HIV Infections; HIV-1; Humans; Organophosphonates; Plasma; Pre-Exposure Prophylaxis; RNA, Viral; Tenofovir | 2015 |
Antiretroviral Pre-Exposure Prophylaxis Does Not Enhance Immune Responses to HIV in Exposed but Uninfected Persons.
Topics: Adenine; Adult; Africa; Animals; Anti-Retroviral Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chemoprevention; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Female; HIV-1; Humans; Male; Organophosphonates; Placebos; Pre-Exposure Prophylaxis; Tenofovir; Young Adult | 2015 |
Assessing the implementation effectiveness and safety of 1% tenofovir gel provision through family planning services in KwaZulu-Natal, South Africa: study protocol for an open-label randomized controlled trial.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Clinical Protocols; Family Planning Services; Female; Gels; Health Services Accessibility; HIV Infections; Humans; Organophosphonates; Program Evaluation; Quality Improvement; Quality Indicators, Health Care; Research Design; Rural Health Services; South Africa; Tenofovir; Time Factors; Treatment Outcome; Urban Health Services; Women's Health Services; Young Adult | 2014 |
Changes in glomerular kidney function among HIV-1-uninfected men and women receiving emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis: a randomized clinical trial.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Kidney Function Tests; Kidney Glomerulus; Male; Medication Adherence; Middle Aged; Organophosphonates; Tenofovir; Young Adult | 2015 |
An intrahepatic transcriptional signature of enhanced immune activity predicts response to peginterferon in chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biopsy; Chi-Square Distribution; Drug Therapy, Combination; Female; Gene Expression Profiling; Genetic Markers; Hepatitis B, Chronic; Humans; Interferon-alpha; Liver; Logistic Models; Male; Middle Aged; Multivariate Analysis; Oligonucleotide Array Sequence Analysis; Organophosphonates; Patient Selection; Polyethylene Glycols; Precision Medicine; Predictive Value of Tests; Recombinant Proteins; Reproducibility of Results; Time Factors; Treatment Outcome | 2015 |
Liver and renal safety of tenofovir disoproxil fumarate in combination with emtricitabine among African women in a pre-exposure prophylaxis trial.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Anti-HIV Agents; Aspartate Aminotransferases; Black People; Chemical and Drug Induced Liver Injury; Creatinine; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Kidney Diseases; Organophosphonates; Phosphorus; Pre-Exposure Prophylaxis; Reverse Transcriptase Inhibitors; Tenofovir; Young Adult | 2014 |
Risk of drug resistance among persons acquiring HIV within a randomized clinical trial of single- or dual-agent preexposure prophylaxis.
Topics: Adenine; Anti-HIV Agents; Anti-Retroviral Agents; Deoxycytidine; Double-Blind Method; Drug Resistance, Viral; Emtricitabine; HIV Infections; HIV Seropositivity; HIV-1; Humans; Organophosphonates; Risk; Tenofovir | 2015 |
Entecavir plus adefovir versus adefovir plus lamivudine in hepatitis B virus e antigen-positive, lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Young Adult | 2014 |
Long-term efficacy and safety of tenofovir disoproxil fumarate in HIV-1-infected adolescents failing antiretroviral therapy: the final results of study GS-US-104-0321.
Topics: Adenine; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Density; Child; Double-Blind Method; Drug Resistance, Viral; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Placebos; RNA, Viral; Tenofovir; Treatment Failure; Viral Load | 2015 |
Tenofovir-based preexposure prophylaxis for HIV infection among African women.
Topics: Adenine; Administration, Intravaginal; Administration, Oral; Adolescent; Adult; Africa South of the Sahara; Anti-Retroviral Agents; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Seropositivity; HIV-1; Humans; Medication Adherence; Middle Aged; Organophosphonates; Pre-Exposure Prophylaxis; Surveys and Questionnaires; Tenofovir; Young Adult | 2015 |
Phase III open-label randomized study of cytarabine in combination with amonafide L-malate or daunorubicin as induction therapy for patients with secondary acute myeloid leukemia.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daunorubicin; Drug Administration Schedule; Female; Humans; Induction Chemotherapy; Infusions, Intravenous; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthalimides; Organophosphonates; Prospective Studies; Remission Induction; Time Factors; Treatment Outcome; Young Adult | 2015 |
A randomized, open-label study of the safety and efficacy of switching stavudine or zidovudine to tenofovir disoproxil fumarate in HIV-1-infected children with virologic suppression.
Topics: Adenine; Adolescent; Anti-HIV Agents; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; RNA, Viral; Stavudine; Tenofovir; Treatment Outcome; Viral Load; Zidovudine | 2015 |
Preemptive adefovir versus lamivudine for prevention of hepatitis B reactivation in chronic hepatitis B patients undergoing chemotherapy.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Neoplasms; Organophosphonates; Virus Activation; Young Adult | 2015 |
Tenofovir monotherapy versus tenofovir and entecavir combination therapy in adefovir-resistant chronic hepatitis B patients with multiple drug failure: results of a randomised trial.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Republic of Korea; Tenofovir; Treatment Outcome | 2016 |
Efficacy of maternal tenofovir disoproxil fumarate in interrupting mother-to-infant transmission of hepatitis B virus.
Topics: Adenine; Adult; DNA, Viral; Female; Follow-Up Studies; Gestational Age; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Maternal Age; Multivariate Analysis; Organophosphonates; Patient Selection; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Prospective Studies; Reference Values; Risk Assessment; Taiwan; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2015 |
Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate in the First Protease Inhibitor-Based Single-Tablet Regimen for Initial HIV-1 Therapy: A Randomized Phase 2 Study.
Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; RNA, Viral; Tenofovir | 2015 |
Efficacy and safety of efavirenz 400 mg daily versus 600 mg daily: 96-week data from the randomised, double-blind, placebo-controlled, non-inferiority ENCORE1 study.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Intention to Treat Analysis; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2015 |
High Mortality Among Non-HIV-Infected People Who Inject Drugs in Bangkok, Thailand, 2005-2012.
Topics: Accidents, Traffic; Adenine; Adult; Anti-HIV Agents; Cause of Death; Double-Blind Method; Drug Overdose; Female; HIV Infections; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Needle Sharing; Organophosphonates; Pre-Exposure Prophylaxis; Risk-Taking; Substance Abuse, Intravenous; Surveys and Questionnaires; Tenofovir; Thailand | 2015 |
Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised, double-blind, phase 3, non-inferiority trials.
Topics: Adenine; Adult; Alanine; Anti-HIV Agents; Arthralgia; Bone Density; Carbamates; CD4 Lymphocyte Count; Cobicistat; Deoxycytidine; Double-Blind Method; Drug Combinations; Emtricitabine; Female; Headache; HIV Infections; Humans; Kidney; Male; Nausea; Organophosphonates; Quinolones; Respiration Disorders; Sleep Initiation and Maintenance Disorders; Tenofovir; Thiazoles; Treatment Outcome; Viral Load | 2015 |
Sexual Relationships Outside Primary Partnerships and Abstinence Are Associated With Lower Adherence and Adherence Gaps: Data From the Partners PrEP Ancillary Adherence Study.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Medication Adherence; Middle Aged; Organophosphonates; Pre-Exposure Prophylaxis; Sexual Abstinence; Sexual Partners; Tenofovir; Uganda; Young Adult | 2015 |
Delayed Reduction of Hepatitis B Viral Load and Dynamics of Adefovir-Resistant Variants during Adefovir plus Entecavir Combination Rescue Therapy.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2015 |
Association Between Level of Hepatitis D Virus RNA at Week 24 of Pegylated Interferon Therapy and Outcome.
Topics: Adenine; Adult; Antiviral Agents; Biopsy; DNA, Viral; Female; Hepatitis B Surface Antigens; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Placebos; Polyethylene Glycols; Recombinant Proteins; RNA, Viral; Transaminases; Treatment Outcome; Viral Load | 2015 |
Dual treatment with atazanavir-ritonavir plus lamivudine versus triple treatment with atazanavir-ritonavir plus two nucleos(t)ides in virologically stable patients with HIV-1 (SALT): 48 week results from a randomised, open-label, non-inferiority trial.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Deoxycytidine; Drug Substitution; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Viral Load; Zidovudine | 2015 |
Cost-effectiveness analysis of lamivudine, telbivudine, and entecavir in treatment of chronic hepatitis B with adefovir dipivoxil resistance.
Topics: Adenine; Adult; Antiviral Agents; Cost-Benefit Analysis; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Telbivudine; Thymidine | 2015 |
[Treatment options in HBeAg-positive chronic hepatitis B patients with a poor response to 24-week interferon monotherapy].
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferons; Organophosphonates | 2015 |
Genital Tenofovir Concentrations Correlate With Protection Against HIV Infection in the CAPRISA 004 Trial: Importance of Adherence for Microbicide Effectiveness.
Topics: Adenine; Adult; Anti-HIV Agents; Case-Control Studies; Cervix Uteri; Female; Gels; HIV Infections; Humans; Medication Adherence; Organophosphonates; South Africa; Tenofovir; Tissue Distribution; Vagina; Young Adult | 2015 |
Brief Report: Cobicistat Compared With Ritonavir as a Pharmacoenhancer for Atazanavir in Combination With Emtricitabine/Tenofovir Disoproxil Fumarate: Week 144 Results.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Cobicistat; Deoxycytidine; Double-Blind Method; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; RNA, Viral; Tenofovir; Thiazoles; Viral Load | 2015 |
Hepatitis B Virus Pregenomic RNA Is Present in Virions in Plasma and Is Associated With a Response to Pegylated Interferon Alfa-2a and Nucleos(t)ide Analogues.
Topics: Adenine; Adult; Amantadine; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Reproducibility of Results; RNA, Viral; Tenofovir; Virion | 2016 |
Tenofovir Gel for the Prevention of Herpes Simplex Virus Type 2 Infection.
Topics: Adenine; Administration, Intravaginal; Adult; Double-Blind Method; Female; Follow-Up Studies; Gels; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; HIV Seronegativity; Humans; Incidence; Kaplan-Meier Estimate; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Young Adult | 2015 |
The curative effect of adefovir dipivoxil treating HBeAg negative chronic hepatitis B and treating HBeAg positive chronic hepatitis B combining interferon α-2b.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Combinations; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Recombinant Proteins | 2015 |
[A randomized controlled trial on 240-week monotherapy with entecavir or adefovir in patients with chronic hepatitis B and cirrhosis].
Topics: Adenine; Aged; Alanine Transaminase; alpha-Fetoproteins; Antiviral Agents; Aspartate Aminotransferases; Biomarkers; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Neoplasms; Male; Organophosphonates; Time Factors | 2015 |
Cost-effectiveness of Lamivudine, Telbivudine, Adefovir Dipivoxil and Entecavir on decompensated hepatitis B virus-related cirrhosis.
Topics: Adenine; Adult; Antiviral Agents; Cost-Benefit Analysis; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome | 2016 |
Simultaneous determination of pradefovir, PMEA and tenofovir in HBV patient serum using liquid chromatography-tandem mass spectrometry and application to phase 2 clinical trial.
Topics: Adenine; Adult; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Linear Models; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tenofovir | 2016 |
[Efficacy Observation of Yiguanjian Decoction Combined Adefovir Dipivoxil Tablet in Treating HBeAg Negative Chronic Viral Hepatitis B Active Compensated Liver Cirrhosis Patients].
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Bilirubin; DNA, Viral; Drugs, Chinese Herbal; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Organophosphonates; Tablets | 2016 |
CONSORT: Effects of adding adefovirdipivoxil to peginterferon alfa-2a at different time points on HBeAg-positivepatients: A prospective, randomized study.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Seroconversion | 2016 |
Effect of nucleoside analogues in the treatment of hepatitis B cirrhosis and its effect on Th17 cell.
Topics: Adenine; Adult; Aged; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Th17 Cells; Treatment Outcome | 2017 |
Peg-interferon plus nucleotide analogue treatment versus no treatment in patients with chronic hepatitis B with a low viral load: a randomised controlled, open-label trial.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Intention to Treat Analysis; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Tenofovir; Viral Load; Young Adult | 2017 |
Combinational use of hepatitis B viral antigens predicts responses to nucleos(t)ide analogue/peg-interferon sequential therapy.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Biomarkers; Drug Administration Schedule; Drug Monitoring; Drug Therapy, Combination; Female; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins | 2018 |
Addition of nucleoside analogues to peg-IFNα-2a enhances virological response in chronic hepatitis B patients without early response to peg-IFNα-2a: a randomized controlled trial.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Sustained Virologic Response | 2017 |
Effects of the combined administration of entecavir and adefovir dipivoxil to improve hepatic fibrosis in hepatitis B patients with interferon resistance.
Topics: Adenine; Aged; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Bilirubin; Creatinine; Drug Resistance, Viral; Drug Therapy, Combination; End Stage Liver Disease; Female; Gene Products, pol; Guanine; Hepatitis B, Chronic; Humans; Interferons; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Severity of Illness Index | 2017 |
Tenofovir
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hospital Costs; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Failure; Viral Load | 2017 |
Evaluating the efficacy of switching from lamivudine plus adefovir to tenofovir disoproxil fumarate monotherapy in lamivudine-resistant stable hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Phosphorous Acids; Prospective Studies | 2018 |
ALT flares during nucleotide analogue therapy are associated with HBsAg loss in genotype A HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Tenofovir; Young Adult | 2018 |
Phase IV randomized clinical study: Peginterferon alfa-2a with adefovir or entecavir pre-therapy for HBeAg-positive chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Taiwan | 2018 |
Combined effect of pegylated interferon α with adefovir on renal function in Chinese patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; China; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Interferon-alpha; Kidney; Male; Organophosphonates; Prospective Studies; Treatment Outcome | 2018 |
Ten-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B virus infection.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Biomarkers; DNA, Viral; Double-Blind Method; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Internationality; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2019 |
Predicting HBsAg clearance in genotype A chronic hepatitis B using HBsAg epitope profiling: A biomarker for functional cure.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Double-Blind Method; Epitope Mapping; Epitopes; Female; Genotype; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Seroconversion; Tenofovir; Viral Load | 2019 |
Safety, efficacy, and pharmacokinetics of pradefovir for the treatment of chronic hepatitis B infection.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Prodrugs; Tenofovir; Treatment Outcome; Viral Load | 2020 |
Adefovir Dipivoxil plus Chinese Medicine in HBeAg-Positive Chronic Hepatitis B Patients: A Randomized Controlled 48-Week Trial.
Topics: Adenine; Adult; Antiviral Agents; Double-Blind Method; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Medicine, Chinese Traditional; Organophosphonates; Young Adult | 2020 |
Mitochondrial toxicity and body shape changes during nucleos(t)ide analogues administration in patients with chronic hepatitis B.
Topics: Adenine; Adiposity; Antiviral Agents; Cross-Sectional Studies; DNA, Mitochondrial; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Mitochondria; Organophosphonates; RNA, Mitochondrial; Tenofovir | 2020 |
Entecavir+tenofovir vs. lamivudine/telbivudine+adefovir in chronic hepatitis B patients with prior suboptimal response.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Sustained Virologic Response; Telbivudine; Tenofovir | 2020 |
Efficacy of 104-week Telbivudine-based optimization strategy in patients with HBeAg-negative chronic hepatitis B virus infections.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; China; Creatinine; DNA, Viral; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Sustained Virologic Response; Telbivudine | 2020 |
Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial.
Topics: Adenine; Adult; Aged; Alanine; Anti-HIV Agents; Double-Blind Method; Drug Therapy, Combination; Emtricitabine; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Pre-Exposure Prophylaxis; Tenofovir; Treatment Outcome; Young Adult | 2021 |
Daily tenofovir disoproxil fumarate/emtricitabine and hydroxychloroquine for pre-exposure prophylaxis of COVID-19: a double-blind placebo-controlled randomized trial in healthcare workers.
Topics: Adenine; Anti-HIV Agents; COVID-19; COVID-19 Drug Treatment; Deoxycytidine; Double-Blind Method; Emtricitabine; Health Personnel; HIV Infections; Humans; Hydroxychloroquine; Organophosphonates; Pre-Exposure Prophylaxis; SARS-CoV-2; Tenofovir | 2023 |
2673 other study(ies) available for organophosphonates and adenine
| Article | Year |
|---|---|
Different pattern of activity of inhibitors of the human immunodeficiency virus in lymphocytes and monocyte/macrophages.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Benzodiazepines; CD4 Antigens; Cytokines; Didanosine; Doxorubicin; Drug Interactions; HIV; HIV Infections; Humans; Imidazoles; Leukocytes, Mononuclear; Lymphocytes; Macrophages; Monocytes; Organ Specificity; Organophosphonates; Zalcitabine; Zidovudine | 1992 |
Flow cytometric method for the detection of gpI antigens of varicella zoster virus and evaluation of anti-VZV agents.
Topics: Adenine; Antibodies, Monoclonal; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Deoxyuracil Nucleotides; Drug Evaluation; Flow Cytometry; Herpesvirus 3, Human; Humans; Organophosphonates; Organophosphorus Compounds; Thymidine Kinase; Viral Envelope Proteins; Virus Replication | 1992 |
Comparative activity of various compounds against clinical strains of herpes simplex virus.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cidofovir; Cytopathogenic Effect, Viral; Cytosine; Dextran Sulfate; Guanine; HeLa Cells; Heparin; Humans; Nucleosides; Organophosphonates; Organophosphorus Compounds; Rabbits; Simplexvirus; Virus Replication | 1992 |
Cell-protecting effect against herpes simplex virus-1 and cellular metabolism of 9-(2-phosphonylmethoxyethyl)adenine in HeLa S3 cells.
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Drug Stability; HeLa Cells; Humans; Hydrogen-Ion Concentration; Organophosphonates; Phosphorylation; Simplexvirus; Solubility; Subcellular Fractions; Time Factors; Tritium; Tumor Cells, Cultured | 1992 |
The acyclic nucleoside analogue penciclovir is a potent inhibitor of equine herpesvirus type 1 (EHV-1) in tissue culture and in a murine model.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cell Line; Drug Resistance, Microbial; Female; Guanine; Herpesviridae Infections; Herpesvirus 1, Equid; Lung; Mice; Mice, Inbred BALB C; Mutation; Organophosphonates; Organophosphorus Compounds; Rabbits; Thymidine Kinase | 1992 |
Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Drug Evaluation, Preclinical; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus | 1992 |
Evaluation of 9-(2-phosphonylmethoxyethyl) adenine therapy for feline immunodeficiency virus using a quantitative polymerase chain reaction.
Topics: Adenine; Animals; Antibodies, Viral; Antigens, Viral; Antiviral Agents; Base Sequence; Cats; DNA, Viral; Drug Administration Schedule; Drug Evaluation; Feline Acquired Immunodeficiency Syndrome; Immunodeficiency Virus, Feline; Injections, Subcutaneous; Molecular Sequence Data; Organophosphonates; Polymerase Chain Reaction; Specific Pathogen-Free Organisms; Virus Replication | 1992 |
Inhibition of reverse transcriptase from feline immunodeficiency virus by analogs of 2'-deoxyadenosine-5'-triphosphate.
Topics: Adenine; Antiviral Agents; Cell Line; Cells, Cultured; Dideoxyadenosine; Immunodeficiency Virus, Feline; Kinetics; Organophosphonates; Reverse Transcriptase Inhibitors; Templates, Genetic | 1992 |
Studies about the oral bioavailability of mitonafide and 2HCl amonafide, two new cytotoxic molecules.
Topics: Adenine; Antineoplastic Agents; Biological Availability; Hydrogen-Ion Concentration; Imides; Intercalating Agents; Isoquinolines; Naphthalimides; Organophosphonates; Solubility | 1992 |
Phosphorylation of 9-(2-phosphonomethoxyethyl)adenine and 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine by AMP(dAMP) kinase from L1210 cells.
Topics: Adenine; Adenylate Kinase; Animals; Creatine Kinase; Isoelectric Point; Leukemia L1210; Mice; Molecular Weight; Organophosphonates; Organophosphorus Compounds; Substrate Specificity; Time Factors; Tumor Cells, Cultured | 1992 |
Acyclic adenine nucleoside phosphonates in plasma determined by high-performance liquid chromatography with fluorescence detection.
Topics: Adenine; Animals; Antiviral Agents; Cats; Chromatography, High Pressure Liquid; Humans; Macaca mulatta; Organophosphonates; Organophosphorus Compounds | 1992 |
Efficacy of 9-(2-phosphonylmethoxyethyl)adenine in the therapy of TK+ and TK- herpes simplex virus experimental keratitis.
Topics: Adenine; Administration, Topical; Animals; Antiviral Agents; Bromodeoxyuridine; Disease Models, Animal; Keratitis, Dendritic; Organophosphonates; Rabbits; Simplexvirus | 1991 |
Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique.
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytomegalovirus; Cytosine; Flow Cytometry; Ganciclovir; Humans; Microbial Sensitivity Tests; Nucleic Acid Hybridization; Organophosphonates; Organophosphorus Compounds; Viral Plaque Assay | 1991 |
Phosphonylmethoxyalkyl purine and pyrimidine derivatives for treatment of opportunistic cytomegalovirus and herpes simplex virus infections in murine AIDS.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus Infections; Cytosine; Ganciclovir; Herpes Simplex; Immune Tolerance; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Opportunistic Infections; Organophosphonates; Organophosphorus Compounds | 1991 |
Isolation of equine herpesvirus-1 mutants in the presence of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine: demonstration of resistance in vitro and in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Drug Resistance, Microbial; Female; Herpesviridae Infections; Herpesvirus 1, Equid; Mice; Mice, Inbred BALB C; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype | 1991 |
Early therapy of feline leukemia virus infection (FeLV-FAIDS) with 9-(2-phosphonylmethoxyethyl)adenine (PMEA).
Topics: Adenine; Animals; Antibodies, Viral; Antigens, Viral; Antiviral Agents; Cats; Cell Line; Feline Acquired Immunodeficiency Syndrome; Leukemia Virus, Feline; Neutralization Tests; Organophosphonates; T-Lymphocytes | 1991 |
Effects of phosphonylmethoxyalkyl-purine and -pyrimidine derivatives on TK+ and TK- HSV-1 keratitis in rabbits.
Topics: Adenine; Animals; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Hempa; Keratitis, Herpetic; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Simplexvirus; Thymidine Kinase | 1991 |
Conversion of acyclic nucleoside phosphonates to their diphosphate derivatives by 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase.
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Biotransformation; Escherichia coli; Kinetics; Organophosphonates; Ribose-Phosphate Pyrophosphokinase; Substrate Specificity | 1991 |
Acyclic nucleotide analogues: synthesis, antiviral activity and inhibitory effects on some cellular and virus-encoded enzymes in vitro.
Topics: Adenine; Adenosine; Antiviral Agents; Cidofovir; Cytosine; DNA Viruses; Guanine; In Vitro Techniques; Nucleic Acid Synthesis Inhibitors; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Inhibitors; Ribonucleotide Reductases; Structure-Activity Relationship; Tubercidin | 1990 |
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound.
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Cattle; Cell Line; DNA Polymerase II; HIV; Humans; Kinetics; Organophosphonates; Phosphorylation; Reverse Transcriptase Inhibitors; Ribose-Phosphate Pyrophosphokinase; Thymus Gland; Tritium | 1991 |
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo.
Topics: Adenine; Animals; Antiviral Agents; Avian Myeloblastosis Virus; Cell Line; Cell Transformation, Neoplastic; DNA Replication; HIV; HIV Reverse Transcriptase; HIV-1; HIV-2; Humans; Mice; Organophosphonates; Organophosphorus Compounds; Purines; Retroviridae; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Structure-Activity Relationship | 1991 |
Immunomodulatory activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA), a potent anti-HIV nucleotide analogue, on in vivo murine models.
Topics: Adenine; Animals; Antiviral Agents; Cytotoxicity, Immunologic; Interferon-alpha; Interferon-beta; Interferons; Interleukin-1; Interleukin-2; Interleukins; Killer Cells, Natural; Mice; Mice, Inbred BALB C; Organophosphonates; Spleen | 1991 |
Inhibitory effect of (S)-HPMPC, (S)-HPMPA, and 2'-nor-cyclic GMP on clinical ocular adenoviral isolates is serotype-dependent in vitro.
Topics: Adenine; Adenovirus Infections, Human; Adenoviruses, Human; Antiviral Agents; Cidofovir; Conjunctivitis, Viral; Cytosine; DNA; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Serotyping; Tumor Cells, Cultured; Viral Plaque Assay | 1991 |
Cellular uptake of phosphonylmethoxyalkylpurine derivatives.
Topics: Adenine; Antiviral Agents; Cell Line; Diffusion; Humans; Organophosphonates; Organophosphorus Compounds | 1991 |
Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo.
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Cell Transformation, Viral; Drug Administration Schedule; Injections, Intraperitoneal; Mice; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental | 1991 |
Determination of 9-[(2-phosphonylmethoxy)ethyl]adenine in rat urine by high-performance liquid chromatography with fluorescence detection.
Topics: Adenine; Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Male; Organophosphonates; Rats; Rats, Inbred Strains; Reproducibility of Results; Spectrometry, Fluorescence | 1991 |
Herpes simplex virus-specified DNA polymerase is the target for the antiviral action of 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Animals; Antiviral Agents; HeLa Cells; Humans; Kinetics; Molecular Structure; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Simplexvirus; Structure-Activity Relationship; Vero Cells | 1991 |
Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro.
Topics: Adenine; Adenosine; Antiviral Agents; Cell Line; Cidofovir; Cytidine; Cytomegalovirus; Cytosine; Ganciclovir; Guanosine; Humans; Nucleosides; Organophosphonates; Organophosphorus Compounds; Thymidine | 1991 |
5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives.
Topics: Adenine; Antiviral Agents; In Vitro Techniques; Kinetics; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Ribose-Phosphate Pyrophosphokinase; Substrate Specificity | 1991 |
Phase II trial of amonafide in patients with stage III and IV non-small-cell lung cancer.
Topics: Adenine; Adenocarcinoma; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Drug Tolerance; Female; Humans; Imides; Intercalating Agents; Isoquinolines; Lung Neoplasms; Male; Middle Aged; Naphthalimides; Neoplasm Staging; Organophosphonates; Remission Induction | 1991 |
Inhibition of the growth of Plasmodium falciparum and Plasmodium berghei by the DNA polymerase inhibitor HPMPA.
Topics: Adenine; Animals; Antiprotozoal Agents; Binding, Competitive; Cell Line; Deoxyadenine Nucleotides; Erythrocytes; Humans; Malaria; Mice; Mice, Inbred BALB C; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Plasmodium berghei; Plasmodium falciparum | 1991 |
Transplacental antiretroviral therapy with 9-(2-phosphonylmethoxyethyl)adenine is embryotoxic in transgenic mice.
Topics: Adenine; Animals; Antiviral Agents; Embryo, Mammalian; Female; Fetal Resorption; Litter Size; Maternal-Fetal Exchange; Mice; Mice, Inbred C57BL; Mice, Transgenic; Moloney murine leukemia virus; Organophosphonates; Pregnancy; Viremia; Zidovudine | 1991 |
Paradoxical relationship between acetylator phenotype and amonafide toxicity.
Topics: Acetylation; Adenine; Antineoplastic Agents; Body Weight; Female; Humans; Imides; Isoquinolines; Leukopenia; Male; Middle Aged; Naphthalimides; Organophosphonates; Phenotype; Prospective Studies | 1991 |
9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys.
Topics: Adenine; Animals; Antibodies, Viral; Antiviral Agents; Blotting, Western; Cell Line; HIV Envelope Protein gp120; Humans; Macaca mulatta; Membrane Glycoproteins; Molecular Structure; Organophosphonates; Retroviridae; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tissue Distribution; Viral Envelope Proteins; Virus Replication | 1991 |
Phosphonylmethoxyalkyl derivatives of purine as inhibitors of human hepatitis B virus DNA synthesis.
Topics: Adenine; Antiviral Agents; DNA Replication; DNA, Viral; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1990 |
Amonafide in metastatic colorectal carcinoma.
Topics: Adenine; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Neoplasm Metastasis; Organophosphonates | 1990 |
Phase II study of amonafide: results of treatment and lessons learned from the study of an investigational agent in previously untreated patients with extensive small-cell lung cancer.
Topics: Adenine; Aged; Antineoplastic Agents; Carcinoma, Small Cell; Clinical Protocols; Drug Evaluation; Drugs, Investigational; Female; Humans; Imides; Infusions, Intravenous; Isoquinolines; Lung Neoplasms; Male; Middle Aged; Naphthalimides; Organophosphonates | 1990 |
Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Humans; Indicators and Reagents; Macrophages; Molecular Structure; Monocytes; Organophosphonates; Polymers; Simplexvirus | 1990 |
Suppression of feline immunodeficiency virus infection in vivo by 9-(2-phosphonomethoxyethyl)adenine.
Topics: Adenine; Animals; Antiviral Agents; Cats; Cell Line; HIV; Immunologic Deficiency Syndromes; Opportunistic Infections; Organophosphonates; Retroviridae; Retroviridae Infections; T-Lymphocytes; Virus Replication; Zidovudine | 1990 |
Synthesis and antiviral activity of (S)-9-[4-hydroxy-3-(phosphonomethoxy)butyl]guanine.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; Guanine; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Viral Plaque Assay | 1990 |
Phosphorylation of acyclic nucleotide analogs HPMPA and PMEA in L1210 mouse leukemia cell extracts.
Topics: Adenine; Adenosine Triphosphate; Animals; Antiviral Agents; Guanylate Kinases; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Nucleoside-Phosphate Kinase; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Tissue Extracts | 1990 |
Effective chemotherapy of equine herpesvirus 1 by phosphonylmethoxyalkyl derivatives of adenine demonstrated in a novel murine model for the disease.
Topics: Adenine; Animals; Antiviral Agents; Culture Techniques; Drug Resistance, Microbial; Herpesviridae Infections; Herpesvirus 1, Equid; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Viral Plaque Assay; Virus Replication | 1990 |
Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Dideoxynucleotides; DNA Polymerase I; DNA Polymerase II; DNA Replication; HeLa Cells; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Thymine Nucleotides; Zidovudine | 1990 |
Phosphonylmethyl ethers of acyclic nucleoside analogues: inhibitors of HSV-1 induced ribonucleotide reductase.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Dose-Response Relationship, Drug; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Ribonucleotide Reductases; Simplexvirus | 1990 |
Inhibitory effects of potent inhibitors of human immunodeficiency virus and cytomegalovirus on the growth of human granulocyte-macrophage progenitor cells in vitro.
Topics: Adenine; Adult; Antiviral Agents; Bone Marrow; Bone Marrow Cells; Cells, Cultured; Cidofovir; Cytomegalovirus; Cytosine; Foscarnet; Ganciclovir; Granulocytes; Hematopoietic Stem Cells; HIV; Humans; Macrophages; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid; Zidovudine | 1990 |
Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant.
Topics: Acyclovir; Adenine; Animals; Bromodeoxyuridine; Drug Resistance, Microbial; Mutation; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Vero Cells; Virus Replication | 1990 |
Inhibitory effects of 9-(2-phosphonylmethoxyethyl)adenine and 3'-azido-2',3'-dideoxythymidine on tumor development in mice inoculated intracerebrally with Moloney murine sarcoma virus.
Topics: Adenine; Animals; Brain Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Mice; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental; Skull Neoplasms; Zidovudine | 1990 |
The cytostatic effects and mechanism of action of antiviral acyclic adenine nucleotide analogs in L1210 mouse leukemia cells.
Topics: Adenine; Animals; Antiviral Agents; Cell Division; DNA; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1990 |
Anti-retrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in vivo increases when it is less frequently administered.
Topics: Adenine; Animals; Antiviral Agents; Cell Transformation, Viral; Cytopathogenic Effect, Viral; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HIV-1; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Neoplasm Transplantation; Organophosphonates; Retroviridae; Sarcoma, Experimental; Time Factors; Zidovudine | 1990 |
Susceptibility of human immunodeficiency virus type 1 replication in vitro to acyclic adenosine analogs and synergy of the analogs with 3'-azido-3'-deoxythymidine.
Topics: Adenine; Adenosine; Animals; Antiviral Agents; Dideoxynucleotides; Drug Synergism; HIV-1; Organophosphonates; Reverse Transcriptase Inhibitors; T-Lymphocytes; Thymine Nucleotides; Virus Replication; Zidovudine | 1989 |
9-(2-Phosphonylmethoxyethyl)adenine in the treatment of murine acquired immunodeficiency disease and opportunistic herpes simplex virus infections.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Antiviral Agents; Concanavalin A; Herpes Simplex; Interferons; Mice; Mice, Inbred C57BL; Mitogens; Opportunistic Infections; Organophosphonates; Spleen; Zidovudine | 1989 |
[Chemotherapy of cytomegalovirus infections].
Topics: Acyclovir; Adenine; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Humans; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid | 1989 |
Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs.
Topics: Adenine; Animals; Cell Line; DNA Damage; DNA Topoisomerases, Type II; DNA, Viral; Haplorhini; Imides; In Vitro Techniques; Intercalating Agents; Isoquinolines; Naphthalimides; Nucleic Acid Conformation; Organophosphonates; Simian virus 40; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1989 |
Mechanism of inhibition of adenovirus DNA replication by the acyclic nucleoside triphosphate analogue (S)-HPMPApp: influence of the adenovirus DNA binding protein.
Topics: Adenine; Adenoviruses, Human; Antiviral Agents; DNA Replication; DNA-Binding Proteins; DNA-Directed DNA Polymerase; DNA, Viral; HeLa Cells; Humans; Kinetics; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Protein Binding; Templates, Genetic; Vaccinia virus | 1989 |
Efficacy of phosphonylmethoxyalkyl derivatives of adenine in experimental herpes simplex virus and vaccinia virus infections in vivo.
Topics: Adenine; Animals; Antiviral Agents; Brain Diseases; Herpes Simplex; Injections; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Hairless; Mice, Nude; Organophosphonates; Organophosphorus Compounds; Vaccinia | 1989 |
Correspondence re: Mark J. Ratain et al., Limited Sampling Models for Amonafide (NSC 308847) Pharmacokinetics.
Topics: Adenine; Antineoplastic Agents; Circadian Rhythm; Humans; Imides; Isoquinolines; Naphthalimides; Organophosphonates | 1989 |
Genotoxicity of [1H]benz[de]isoquinoline-1,3[2H]dione,5 amino-2-,[2-dimethylamino) ethyl] (BIDA) in human lymphocytes.
Topics: Adenine; Adult; Antineoplastic Agents; Cells, Cultured; Chromosome Aberrations; Humans; Imides; Interphase; Isoquinolines; Lymphocyte Activation; Lymphocytes; Male; Mutagens; Naphthalimides; Organophosphonates; Phytohemagglutinins; Sister Chromatid Exchange | 1989 |
Intracellular phosphorylation of broad-spectrum anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and inhibition of viral DNA synthesis.
Topics: Adenine; Animals; Antiviral Agents; DNA, Viral; Herpes Simplex; Leukemia L1210; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Simplexvirus; Tumor Cells, Cultured; Virus Replication | 1987 |
Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication.
Topics: Adenine; Adenosine; Antimetabolites; Antiviral Agents; Cell Line; Cell Survival; DNA, Viral; Herpesvirus 4, Human; Organophosphonates; Organophosphorus Compounds; Virus Replication | 1987 |
Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents.
Topics: Adenine; Animals; Antiviral Agents; Cytopathogenic Effect, Viral; HIV; HLA-D Antigens; Humans; Hydrolysis; Mice; Mice, Inbred C3H; Organophosphonates; Organophosphorus Compounds; Purines; Pyrimidines; Sarcoma Viruses, Murine; Structure-Activity Relationship; Virus Replication | 1988 |
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; HIV; Mice; Mice, Inbred Strains; Moloney murine sarcoma virus; Organophosphonates; Sarcoma, Experimental | 1989 |
In vitro toxicity and DNA cleaving capacity of benzisoquinolinedione (nafidimide; NSC 308847) in human leukemia.
Topics: Adenine; Amsacrine; Cell Line; Clone Cells; DNA; DNA Topoisomerases, Type I; Doxorubicin; Electrophoresis, Agar Gel; Humans; Imides; In Vitro Techniques; Intercalating Agents; Isoquinolines; Leukemia, Myeloid, Acute; Mathematics; Naphthalimides; Organophosphonates | 1987 |
In vitro activity of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against newly isolated clinical varicella-zoster virus strains.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Fibroblasts; Herpesvirus 3, Human; Humans; Organophosphonates; Organophosphorus Compounds; Virus Replication | 1987 |
In vitro activity of amonafide against primary human tumors compared with the activity of standard agents.
Topics: Adenine; Antineoplastic Agents; Drug Evaluation; Drug Evaluation, Preclinical; Hematopoietic Stem Cells; Humans; Imides; Isoquinolines; Naphthalimides; Organophosphonates; Tumor Cells, Cultured | 1988 |
Pharmacokinetics of Amonafide in dogs.
Topics: Adenine; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dogs; Female; Fluorometry; Gas Chromatography-Mass Spectrometry; Imides; Infusions, Intravenous; Isoquinolines; Male; Naphthalimides; Organophosphonates; Oxidation-Reduction; Regression Analysis; Software; Tissue Distribution | 1988 |
Limited sampling models for amonafide (NSC 308847) pharmacokinetics.
Topics: Adenine; Drug Evaluation; Humans; Imides; Intercalating Agents; Isoquinolines; Naphthalimides; Organophosphonates | 1988 |
Inhibition of African swine fever virus DNA synthesis by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine.
Topics: Adenine; African Swine Fever Virus; Animals; Antiviral Agents; Cell Line; DNA Replication; DNA, Viral; Humans; Iridoviridae; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid; Vero Cells | 1988 |
Comparative efficacy of broad-spectrum antiviral agents as inhibitors of African swine fever virus replication in vitro.
Topics: Adenine; African Swine Fever Virus; Amides; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Iridoviridae; Organophosphonates; Organophosphorus Compounds; Pyrazoles; Ribavirin; Ribonucleosides; Ribose; Thymidine; Tubercidin; Vero Cells; Virus Replication; Zidovudine | 1987 |
Selective inhibitory effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 2'-nor-cyclic GMP on adenovirus replication in vitro.
Topics: Adenine; Adenoviruses, Human; Antiviral Agents; Cells, Cultured; Cytopathogenic Effect, Viral; Fibroblasts; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Virus Replication | 1987 |
Selective inhibitory effects of (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl) adenine and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil on seal herpesvirus (phocid herpesvirus 1) infection in vitro.
Topics: Adenine; Animals; Antiviral Agents; Arabinofuranosyluracil; Cells, Cultured; Herpesviridae; Organophosphonates; Organophosphorus Compounds; Seals, Earless; Uridine | 1987 |
Phase I clinical investigation of benzisoquinolinedione.
Topics: Adenine; Adult; Aged; Antineoplastic Agents; Blood Cell Count; Dose-Response Relationship, Drug; Drug Evaluation; Female; Hematopoiesis; Humans; Imides; Isoquinolines; Male; Middle Aged; Naphthalimides; Organophosphonates | 1987 |
Stereospecific syntheses of 9-(S)-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA).
Topics: Adenine; Antiviral Agents; Indicators and Reagents; Organophosphonates; Organophosphorus Compounds; Stereoisomerism | 1987 |
Sensitive reversed-phase high-performance liquid chromatographic assay for the antitumor agent benzisoquinolinedione (Nafidimide) employing direct on-column injection of plasma and urine, and its use for pharmacokinetic studies in a dog.
Topics: Adenine; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dogs; Female; Half-Life; Imides; Injections, Intravenous; Isoquinolines; Kinetics; Naphthalimides; Organophosphonates | 1985 |
High-performance liquid chromatographic separation and quantitation of benzisoquinolinedione (Nafidimide) from biological fluids.
Topics: Adenine; Animals; Antineoplastic Agents; Bile; Body Fluids; Chromatography, High Pressure Liquid; Dogs; Imides; Isoquinolines; Kinetics; Naphthalimides; Organophosphonates | 1985 |
Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the adenosine triphosphate binding site.
Topics: Acylation; Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alcohols; Amino Acyl-tRNA Synthetases; Binding Sites; Cyclohexanes; Deoxyadenosines; Diphosphates; Escherichia coli; Organophosphonates; Phosphoric Acids; Phosphorus Isotopes; Protein Binding; Purines; Structure-Activity Relationship; Thermodynamics | 1971 |
Antiviral action of 5-amino-2-(2-dimethyl-aminoethyl)benzo-[de]-isoquinolin-1,3-dion e.
Topics: Adenine; African Swine Fever Virus; Animals; Antiviral Agents; Cell Line; Cell Survival; Chick Embryo; Chlorocebus aethiops; DNA Replication; Drug Evaluation, Preclinical; Imides; Iridoviridae; Isoquinolines; Kidney; Kinetics; Naphthalimides; Organophosphonates; Simplexvirus; Virus Replication | 1984 |
Imide derivatives of 3-nitro-1.8-naphthalic acid: their inhibitory activity against DNA viruses.
Topics: Adenine; Adenoviruses, Human; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Chick Embryo; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Imides; Isoquinolines; Naphthalimides; Organophosphonates; Simplexvirus; Time Factors; Virus Replication | 1982 |
[Antineoplastic drugs used as fluorochromes].
Topics: Adenine; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chickens; DNA; Fluorescent Dyes; Imides; Isoquinolines; Naphthalimides; Organophosphonates | 1982 |
K65R mutation of human immunodeficiency virus type 1 reverse transcriptase encodes cross-resistance to 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Antiviral Agents; Cell-Free System; Cloning, Molecular; Culture Techniques; Drug Resistance, Microbial; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Organophosphonates; RNA-Directed DNA Polymerase | 1995 |
Drug prevents SIV infection.
Topics: Adenine; Animals; Antiviral Agents; Macaca fascicularis; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Tenofovir | 1995 |
AIDS research. New drug shows promise in monkeys.
Topics: Adenine; Animals; Antiviral Agents; HIV; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Macaca fascicularis; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 1995 |
Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine.
Topics: Adenine; Animals; Antibodies, Viral; Antiviral Agents; Base Sequence; Cells, Cultured; HIV Infections; Humans; Injections, Subcutaneous; Leukocytes, Mononuclear; Lymph Nodes; Macaca fascicularis; Molecular Sequence Data; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 1995 |
Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates.
Topics: Adenine; Animals; Antiviral Agents; Interferons; Killer Cells, Natural; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; Time Factors | 1994 |
High recombinagenic activities of three antiviral agents, adenine derivatives, in the Drosophila wing spot test.
Topics: Abnormalities, Drug-Induced; Adenine; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Drosophila melanogaster; Female; Larva; Male; Mitosis; Mutagenicity Tests; Mutagens; Organophosphonates; Recombination, Genetic; Wings, Animal | 1994 |
Efficacy of 9-(2-phosphonylmethoxyethyl)adenine treatment against chronic simian immunodeficiency virus infection in macaques.
Topics: Adenine; Animals; Antiviral Agents; Chronic Disease; DNA, Viral; Leukocytes, Mononuclear; Lymphocyte Subsets; Macaca fascicularis; Organophosphonates; Proviruses; RNA-Directed DNA Polymerase; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus | 1995 |
Transport of 9-(2-phosphonomethoxyethyl)adenine across plasma membrane of HeLa S3 cells is protein mediated.
Topics: Adenine; Antiviral Agents; Biological Transport; Cell Membrane; Cells, Cultured; HeLa Cells; Humans; Organophosphonates; Structure-Activity Relationship | 1995 |
Amino-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H- dibenz[de,h]isoquinoline-1,3-diones. Synthesis, antitumor activity, and quantitative structure--activity relationship.
Topics: Adenine; Animals; Antineoplastic Agents; Cattle; Colonic Neoplasms; DNA; Doxorubicin; Heart Diseases; Humans; Imides; Isoquinolines; Leukemia P388; Male; Mice; Mice, Inbred DBA; Mitoxantrone; Naphthalimides; Organophosphonates; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines.
Topics: Adenine; Adenine Nucleotides; Animals; Antineoplastic Agents; Antiviral Agents; Cell Differentiation; Cell Division; Choriocarcinoma; HIV; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Promyelocytic, Acute; Organophosphonates; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tumor Cells, Cultured | 1995 |
Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates.
Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Foscarnet; Organophosphonates; Organophosphorus Compounds; Vero Cells | 1995 |
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs.
Topics: Adenine; Animals; Antibodies, Viral; Antiviral Agents; Brain; Cytopathogenic Effect, Viral; Disease Models, Animal; Drug Evaluation, Preclinical; HIV Infections; Leukocytes, Mononuclear; Organophosphonates; Sheep; Visna; Visna-maedi virus | 1995 |
Synthesis and in vivo evaluation of prodrugs of 9-[2-(phosphonomethoxy)ethoxy]adenine.
Topics: Adenine; Animals; Antiviral Agents; Biological Availability; Female; Intestinal Absorption; Mice; Mice, Inbred BALB C; Organophosphonates; Prodrugs | 1995 |
Antitrypanosomal activity of phosphonylmethoxyalkylpurines.
Topics: Adenine; Animals; Cidofovir; Cytosine; Female; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Purines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma congolense; Trypanosomiasis, African | 1994 |
Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture.
Topics: Adenine; Animals; Antiviral Agents; Carcinoma, Hepatocellular; Cytosine; Ducks; Hepatitis B virus; Hepatitis B Virus, Duck; Humans; Liver; Liver Neoplasms; Nucleosides; Organophosphonates; Organophosphorus Compounds; Purines; Tumor Cells, Cultured | 1994 |
Conversion of adenosine(5') oligophospho(5') adenosines into inosine(5') oligophospho(5') inosines by non-specific adenylate deaminase from the snail Helix pomatia.
Topics: Adenine; AMP Deaminase; Animals; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Helix, Snails; Inosine; Organophosphonates; Spectrophotometry, Ultraviolet; Thionucleotides | 1995 |
The effect of (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl) adenine on nuclear and organellar DNA synthesis in erythrocytic schizogony in malaria.
Topics: Adenine; Animals; Antimalarials; Cell Nucleus; DNA Replication; DNA, Protozoan; Erythrocytes; Humans; In Vitro Techniques; Kinetics; Malaria, Falciparum; Organelles; Organophosphonates; Organophosphorus Compounds; Plasmodium falciparum; Ribonucleotide Reductases | 1994 |
9-(2-Phosphonylmethoxyethyl) adenine increases the survival of influenza virus-infected mice by an enhancement of the immune system.
Topics: Adenine; Animals; Cell Line; Cytopathogenic Effect, Viral; Dogs; Immunologic Factors; Influenza A virus; Kidney; Mice; Mice, Inbred C57BL; Organophosphonates; Orthomyxoviridae Infections | 1994 |
Immunomodulatory properties of 9-(2-phosphonomethoxyethyl)-adenine (PMEA).
Topics: Adenine; Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; Cells, Cultured; Graft vs Host Reaction; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Organophosphonates | 1994 |
Base sequence determinants of amonafide stimulation of topoisomerase II DNA cleavage.
Topics: Adenine; Animals; Antineoplastic Agents; Base Sequence; Binding Sites; DNA; DNA Topoisomerases, Type II; DNA, Viral; Imides; Isoquinolines; Leukemia P388; Mice; Molecular Sequence Data; Naphthalimides; Organophosphonates; Sequence Analysis, DNA; Simian virus 40 | 1995 |
A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent.
Topics: Adenine; Adenosine Kinase; Antiviral Agents; Biological Transport; Cell Line; Deoxycytidine Kinase; Drug Resistance; Humans; Organophosphonates; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); T-Lymphocytes | 1995 |
New inhibitors of cytomegalovirus replication: in vitro evaluation, mechanism of action, and in vivo activity.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; DNA, Viral; Ganciclovir; Herpesviridae Infections; Humans; Immunologic Deficiency Syndromes; Mice; Mice, SCID; Muromegalovirus; Organophosphonates; Organophosphorus Compounds; Virus Replication | 1994 |
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). III. Rat and mouse carcinomas and sarcomas.
Topics: Adenine; Animals; Antiviral Agents; Carcinoma; Female; Mice; Mice, Inbred C57BL; Organophosphonates; Rats; Rats, Inbred BN; Rats, Inbred Lew; Sarcoma, Experimental; Tumor Cells, Cultured | 1993 |
Oral bioavailability of the antiretroviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from three formulations of the prodrug bis(pivaloyloxymethyl)-PMEA in fasted male cynomolgus monkeys.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Adenine; Animals; Antiviral Agents; beta-Cyclodextrins; Biological Availability; Cyclodextrins; Macaca fascicularis; Male; Organophosphonates; Prodrugs; Propylene Glycols; Retroviridae; Suspensions | 1994 |
Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates.
Topics: Adenine; Antiviral Agents; Cell Line; Drug Resistance, Microbial; HIV-1; Humans; Molecular Structure; Organophosphonates; Organophosphorus Compounds; T-Lymphocytes; Zidovudine | 1994 |
Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Topics: Adenine; Animals; Antiviral Agents; Biological Availability; Male; Organophosphonates; Prodrugs; Rats | 1994 |
Qualitative and quantitative determination of two new antitumor agents from 1-8 naphthalimides in tablets. Validation of a high performance liquid chromatography method.
Topics: Adenine; Antineoplastic Agents; Chromatography, High Pressure Liquid; Excipients; Imides; Isoquinolines; Naphthalimides; Organophosphonates; Regression Analysis; Tablets | 1994 |
[Sensitivities to other antiviral drugs and thymidine kinase activity of aciclovir-resistant herpes simplex virus type 1].
Topics: Acyclovir; Adenine; Antiviral Agents; Drug Resistance, Microbial; Ganciclovir; Guanine; Herpesvirus 1, Human; Humans; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Thymidine Kinase; Vidarabine | 1994 |
Preexposure prophylaxis with 9-(2-phosphonylmethoxyethyl)adenine against simian immunodeficiency virus infection in macaques.
Topics: Adenine; Animals; Antibodies, Viral; Base Sequence; DNA Primers; DNA, Viral; Dose-Response Relationship, Drug; Leukocytes, Mononuclear; Macaca; Molecular Sequence Data; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocyte Subsets | 1994 |
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). I. Lymphatic leukemia KHP-Lw-I in Lewis rats.
Topics: Adenine; Animals; Antineoplastic Agents; Leukemia, Experimental; Leukemia, Lymphoid; Male; Organophosphonates; Rats; Rats, Inbred Lew | 1993 |
Cytostatic effect of 9-(2-phosphonomethoxyethyl) adenine (PMEA). II. Lymphoblastic leukemia in Sprague-Dawley rats.
Topics: Adenine; Animals; Antineoplastic Agents; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Experimental; Leukemic Infiltration; Male; Organophosphonates; Rats; Rats, Sprague-Dawley | 1993 |
Antimitotic and teratogenic effects of acyclic nucleotide analogues 1-(S)-(3-hydroxy-2-phosphonomethoxyethyl)cytosine (HPMPC) and 9-(2-phosphonomethoxyethyl) adenine (PMEA).
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Chick Embryo; Cidofovir; Cytosine; Female; Fibroblasts; Humans; Lung; Male; Mitosis; Organophosphonates; Organophosphorus Compounds; Polydactyly; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1993 |
Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Biological Availability; Body Fluid Compartments; Carbon Radioisotopes; Dose-Response Relationship, Drug; Female; Injections, Intramuscular; Injections, Intravenous; Injections, Subcutaneous; Macaca fascicularis; Male; Organophosphonates | 1994 |
Model of acute graft-vs-host-disease in adult (SHR x BN.lx)F1 rats and its inhibition by adenine analog.
Topics: Adenine; Animals; Bone Marrow Transplantation; Disease Models, Animal; Female; Graft vs Host Disease; Hybridization, Genetic; Immunosuppressive Agents; Male; Organophosphonates; Rats; Rats, Inbred BN; Rats, Inbred SHR; Transplantation, Homologous | 1993 |
Bis-naphthalimides: a new class of antitumor agents.
Topics: Adenine; Animals; Antineoplastic Agents; Humans; Imides; Intercalating Agents; Isoquinolines; Mice; Naphthalenes; Naphthalimides; Neoplasms, Experimental; Organophosphonates; Structure-Activity Relationship; Tumor Cells, Cultured | 1993 |
Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates.
Topics: Adenine; Antiviral Agents; Extracellular Space; HIV-1; Humans; Kinetics; Lymphoid Tissue; Nucleosides; Organophosphonates; Prodrugs; Time Factors | 1993 |
Prevention of acute graft-versus-host disease in rats using 9-(2-phosphonomethoxyethyl) adenine (PMEA).
Topics: Acute Disease; Adenine; Animals; Disease Models, Animal; Female; Graft vs Host Disease; Immunosuppressive Agents; Immunotherapy; Injections, Intraperitoneal; Organophosphonates; Rats; Rats, Inbred BN; Rats, Inbred SHR | 1993 |
Intracellular delivery of nucleoside monophosphates through a reductase-mediated activation process.
Topics: Adenine; Antiviral Agents; B-Lymphocytes; Cell Line; Dideoxynucleosides; Dideoxynucleotides; Esters; HIV-1; Humans; Organophosphonates; Oxidoreductases; Prodrugs; T-Lymphocytes; Thymine Nucleotides; Uridine Monophosphate; Zidovudine | 1993 |
Effects of phosphonylmethoxyalkyl derivatives studied with a murine model for abortion induced by equine herpesvirus 1.
Topics: Abortion, Spontaneous; Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Female; Herpesviridae Infections; Herpesvirus 1, Equid; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Pregnancy; Virus Replication | 1993 |
The effect of purine phosphonomethoxyalkyl derivatives on DNA synthesis in CHO Chinese hamster cells.
Topics: Adenine; Animals; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Cytarabine; DNA Damage; DNA Replication; Dose-Response Relationship, Drug; Guanine; Organophosphonates; Organophosphorus Compounds; Zidovudine | 1993 |
Mechanism of action of acyclic nucleoside phosphonates against herpes virus replication.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cell Nucleus; Cidofovir; Cytosine; Herpesviridae; Humans; Organophosphonates; Organophosphorus Compounds; Retroviridae; Structure-Activity Relationship; Thymidine Kinase; Virus Replication | 1994 |
Inhibitory effect of 9-(2-phosphonylmethoxyethyl)-adenine (PMEA) on human and duck hepatitis B virus infection.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; DNA, Viral; Ducks; Evaluation Studies as Topic; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Humans; Liver; Organophosphonates; Virus Replication | 1993 |
The correlation of response with plasma pharmacokinetics and polyamine concentrations in patients with acute myelogenous leukemia receiving amonafide.
Topics: Adenine; Antineoplastic Agents; Chromatography, High Pressure Liquid; Half-Life; Humans; Imides; Isoquinolines; Leukemia, Myeloid, Acute; Leukocyte Count; Metabolic Clearance Rate; Naphthalimides; Organophosphonates; Polyamines; Regression Analysis; Time Factors | 1993 |
The pathogenesis of wild type and drug resistant mutant strains of bovine herpesvirus-1 (BHV-1) in the natural host.
Topics: Adenine; Animals; Antibodies, Viral; Antiviral Agents; Cattle; Cells, Cultured; Drug Resistance, Microbial; Herpesvirus 1, Bovine; Infectious Bovine Rhinotracheitis; Mutation; Nasal Mucosa; Organophosphonates; Organophosphorus Compounds | 1993 |
Efficacy of (S)-HPMPA against thymidine kinase-deficient herpes simplex virus-keratitis.
Topics: Adenine; Administration, Topical; Animals; Antiviral Agents; Bromodeoxyuridine; Deoxyuridine; Herpesvirus 1, Human; Keratitis, Herpetic; Ophthalmic Solutions; Organophosphonates; Organophosphorus Compounds; Rabbits; Thymidine Kinase | 1987 |
Synthesis, structure and antitumor activity of new benz[d,e]isoquinoline-1,3-diones.
Topics: Adenine; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Imides; Isoquinolines; Leukemia L1210; Mice; Mice, Inbred DBA; Models, Molecular; Molecular Conformation; Naphthalimides; Organophosphonates; Tumor Cells, Cultured | 1995 |
Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.
Topics: Adenine; Antiviral Agents; Cell Line; Dose-Response Relationship, Drug; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Soman; Stereoisomerism; Structure-Activity Relationship; Virus Replication | 1996 |
Suppression of rat adjuvant arthritis by some acyclic nucleotide analogs.
Topics: Adenine; Animals; Arthritis, Experimental; Cidofovir; Cytosine; Female; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Inbred BN; Rats, Inbred Lew | 1995 |
Metabolic pathways for activation of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine in human lymphoid cells.
Topics: Adenine; Adenylate Kinase; Antiviral Agents; Biotransformation; Cell Line; Humans; Lymphocytes; Organophosphonates; Phosphorylation; Substrate Specificity; Sulfhydryl Reagents | 1995 |
(S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA]: a purine analogue with trypanocidal activity in vitro and in vivo.
Topics: Acute Disease; Adenine; Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Female; Mice; Mice, Inbred ICR; Organophosphonates; Organophosphorus Compounds; Trypanocidal Agents; Trypanosomiasis | 1996 |
Antiviral activity of selected acyclic nucleoside analogues against human herpesvirus 6.
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytopathogenic Effect, Viral; Cytosine; Flow Cytometry; Foscarnet; Ganciclovir; Herpesvirus 6, Human; Humans; Nucleosides; Organophosphonates; Organophosphorus Compounds | 1995 |
Synthesis and biological evaluation of1',2'-seconucleo-5'- phosphonates.
Topics: Adenine; Adenoviruses, Human; Antiviral Agents; Cystine; HIV; Molecular Structure; Nucleotides; Organophosphonates; Organophosphorus Compounds; RNA Viruses; Thymine; Uracil | 1996 |
Potent inhibition of human immunodeficiency virus and herpes simplex virus type 1 by 9-(2-phosphonylmethoxyethyl)adenine in primary macrophages is determined by drug metabolism, nucleotide pools, and cytokines.
Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Deoxyadenine Nucleotides; Granulocyte-Macrophage Colony-Stimulating Factor; Herpesvirus 1, Human; HIV; Humans; Macrophage Colony-Stimulating Factor; Macrophages; Organophosphonates; Vero Cells | 1996 |
MDL 74,968, a new acyclonucleotide analog: activity against human immunodeficiency virus in vitro and in the hu-PBL-SCID.beige mouse model of infection.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Didanosine; DNA, Viral; Guanine; HIV Infections; HIV-1; HIV-2; Humans; Male; Mice; Mice, SCID; Monocytes; Organophosphonates; Spleen; T-Lymphocytes; Zidovudine | 1996 |
Comparative kinetic analyses of interaction of inhibitors with Rauscher murine leukemia virus and human immunodeficiency virus reverse transcriptases.
Topics: Adenine; Antiviral Agents; HIV Reverse Transcriptase; HIV-1; Kinetics; Organophosphonates; Phosphates; Rauscher Virus; Reverse Transcriptase Inhibitors; Stavudine; Virus Replication; Zidovudine | 1996 |
Computer simulation of the binding of amonafide and azonafide to DNA.
Topics: Adenine; Base Sequence; Binding Sites; Calorimetry; Computer Simulation; DNA; Hydrogen Bonding; Imides; Intercalating Agents; Isoquinolines; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Naphthalimides; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Organophosphonates | 1996 |
Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Female; Friend murine leukemia virus; Humans; In Vitro Techniques; Leukemia, Experimental; Mice; Mice, Inbred Strains; Mice, SCID; Moloney murine sarcoma virus; Organophosphonates; Prodrugs; Rats; Retroviridae; Retroviridae Infections; Sarcoma, Experimental; Tumor Virus Infections | 1996 |
Antimalarial and toxic effects of the acyclic nucleoside phosphonate (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine in Plasmodium berghei-infected mice.
Topics: Adenine; Animals; Antimalarials; Delayed-Action Preparations; Malaria; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Plasmodium berghei; Probenecid | 1996 |
Application of a gastric cancer cell line (MKN-28) for anti-adenovirus screening using the MTT method.
Topics: Adenine; Adenoviruses, Human; Antiviral Agents; Cidofovir; Cytosine; Drug Evaluation, Preclinical; Formazans; Ganciclovir; Humans; Idoxuridine; Organophosphonates; Organophosphorus Compounds; Purines; Stomach Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1996 |
Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender.
Topics: Acetylation; Adenine; Adult; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Imides; Isoquinolines; Leukocyte Count; Leukopenia; Male; Middle Aged; Models, Biological; Naphthalimides; Organophosphonates; Phenotype; Prospective Studies; Sex Factors | 1996 |
Colorimetric assay system for screening antiviral compounds against hepatitis B virus.
Topics: Adenine; Antiviral Agents; Base Sequence; Colorimetry; DNA Primers; DNA, Viral; Drug Evaluation, Preclinical; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Molecular Sequence Data; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1996 |
Patterns of resistance and sensitivity to antiviral compounds of drug-resistant strains of human cytomegalovirus selected in vitro.
Topics: Acyclovir; Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytarabine; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; Drug Resistance, Microbial; Fibroblasts; Foscarnet; Humans; Lung; Organophosphonates; Organophosphorus Compounds; Phosphonoacetic Acid | 1996 |
Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro.
Topics: Adenine; Antiviral Agents; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Oligonucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; Virus Replication | 1996 |
In vitro selection and molecular characterization of human immunodeficiency virus type 1 with reduced sensitivity to 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Topics: Adenine; Amino Acid Sequence; Anti-HIV Agents; Cell Line; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Organophosphonates; Point Mutation; Serial Passage | 1996 |
Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells.
Topics: Adenine; Antineoplastic Agents; Cell Differentiation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia, Erythroblastic, Acute; Nucleosides; Organophosphonates; Phenotype; Purines; Pyrimidines; Tritium; Tumor Cells, Cultured | 1996 |
9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques.
Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antibodies, Viral; Drug Resistance; Immunoglobulin G; Macaca mulatta; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Phenotype; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir | 1996 |
An ocular model of Adenovirus type 5 infection in the rabbit.
Topics: Adenine; Adenoviridae; Adenoviridae Infections; Animals; Antiviral Agents; Cidofovir; Cytosine; Disease Models, Animal; Eye Diseases; Organophosphonates; Organophosphorus Compounds; Rabbits; Virus Replication | 1995 |
Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability.
Topics: Adenine; Administration, Oral; Antiviral Agents; Biological Availability; Cell Line; Drug Stability; Herpesvirus 1, Human; Humans; Magnetic Resonance Spectroscopy; Organophosphonates; Prodrugs; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Red blood cells mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to primary macrophages: efficiency metabolism and activity against human immunodeficiency virus or herpes simplex virus.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Cells, Cultured; Chlorocebus aethiops; Drug Carriers; Erythrocytes; Herpesvirus 1, Human; HIV-1; Humans; Macrophages; Organophosphonates; Vero Cells | 1997 |
Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NM
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Cell Line; Fibroblasts; Guanine; Humans; Mice; Mice, Inbred C3H; Organophosphonates; Organophosphorus Compounds; Retroviridae; Retroviridae Infections; Sarcoma Viruses, Murine; Tenofovir | 1997 |
Early treatment with 9-(2-phosphonylmethoxyethyl)adenine reduces virus burdens for a prolonged period in SIV-infected rhesus macaques.
Topics: Adenine; Animals; Antiviral Agents; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Viral Load; Virus Replication | 1997 |
Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Topics: Adenine; Animals; Antiviral Agents; Caco-2 Cells; Chromatography, High Pressure Liquid; Humans; Intestinal Absorption; Organophosphonates; Prodrugs; Swine | 1997 |
Effects of (R)-9-(2-phosphonylmethoxypropyl)adenine monotherapy on chronic SIV infection in macaques.
Topics: Adenine; Animals; Antiviral Agents; CD4-Positive T-Lymphocytes; Drug Evaluation; Lymphocyte Count; Lymphocyte Subsets; Lymphoid Tissue; Macaca fascicularis; Organophosphonates; Organophosphorus Compounds; Retroviridae Infections; Simian Immunodeficiency Virus; Tenofovir | 1997 |
Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Biological Availability; Injections, Intravenous; Magnetic Resonance Spectroscopy; Male; Organophosphonates; Prodrugs; Rats; Rats, Sprague-Dawley | 1997 |
Intracellular metabolism and action of acyclic nucleoside phosphonates on DNA replication.
Topics: Adenine; Antineoplastic Agents; Cell Line; DNA Replication; DNA-Directed DNA Polymerase; Guanine; Humans; Organophosphonates; Organophosphorus Compounds; Simian virus 40; Tenofovir | 1997 |
(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) inhibits HIV-1 replication in epithelial cells, but not T-lymphocytes.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; CD4 Antigens; Cell Line; Cidofovir; Cytosine; Genetic Engineering; HeLa Cells; Herpesvirus 1, Human; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Phosphorylation; T-Lymphocytes; Virus Replication | 1997 |
Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production.
Topics: Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Culture Media; Cytokines; Female; Immunohistochemistry; Indomethacin; Interferon-gamma; Interleukin-10; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Organophosphonates; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Stimulation, Chemical; Tenofovir; Theophylline; Tumor Necrosis Factor-alpha | 1997 |
Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection.
Topics: Adenine; AIDS Vaccines; Animals; Antiviral Agents; Cells, Cultured; Humans; Kinetics; Lymphocytes; Macaca nemestrina; Models, Theoretical; Organophosphonates; Polymerase Chain Reaction; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Time Factors; Viral Vaccines; Viremia; Virus Replication | 1997 |
Antiviral drug susceptibility of human herpesvirus 8.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA Replication; DNA, Viral; Herpesvirus 8, Human; Humans; Organophosphonates; Organophosphorus Compounds | 1997 |
Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Biological Availability; Dogs; Fasting; Food-Drug Interactions; Hydrogen-Ion Concentration; Injections, Intravenous; Male; Organophosphonates; Pentagastrin; Solubility; Tablets | 1997 |
Anti-HIV activity of adefovir (PMEA) and PMPA in combination with antiretroviral compounds: in vitro analyses.
Topics: Adenine; Anti-HIV Agents; Drug Interactions; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; Tumor Cells, Cultured | 1997 |
In vitro characterization of the anti-human cytomegalovirus activity of PMEA (Adefovir).
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; HeLa Cells; Humans; Organophosphonates | 1997 |
Metabolism and pharmacokinetics of novel oral prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.
Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Area Under Curve; Biological Availability; Dogs; Drug Stability; Esterases; Half-Life; Injections, Intravenous; Intestinal Mucosa; Liver; Male; Organophosphonates; Organophosphorus Compounds; Prodrugs; Structure-Activity Relationship; Tenofovir | 1997 |
The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II.
Topics: Adenine; Alleles; Antineoplastic Agents; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Humans; Imides; Isoquinolines; Mesylates; Naphthalimides; Organophosphonates; Saccharomyces cerevisiae | 1998 |
Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA.
Topics: Adenine; Anti-HIV Agents; Blood Platelets; HIV; Humans; Leukocytes, Mononuclear; Organophosphonates; Organophosphorus Compounds; Prodrugs; T-Lymphocytes; Tenofovir | 1998 |
Pharmacokinetics and bioavailability of the anti-human immunodeficiency virus nucleotide analog 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in dogs.
Topics: Adenine; Animals; Anti-HIV Agents; Bile; Biological Availability; Chromatography, High Pressure Liquid; Dogs; Injections, Intravenous; Male; Metabolic Clearance Rate; Organophosphonates; Organophosphorus Compounds; Tenofovir | 1998 |
Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Topics: Adenine; Antiviral Agents; Caco-2 Cells; Chromatography, Ion Exchange; Esters; Humans; Organophosphonates; Prodrugs | 1998 |
Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
Topics: Adenine; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Antineoplastic Agents; Biological Transport; Biotransformation; Cell Survival; Cyclic AMP; Drug Resistance, Neoplasm; Guanine; Kinetics; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Purine Nucleotides; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment.
Topics: Adenine; Animals; Antiviral Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Drug Administration Schedule; Drug Evaluation; Female; Humans; Macaca fascicularis; Male; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Tumor Cells, Cultured; Virus Latency | 1998 |
Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats.
Topics: Adenine; Animals; Antiviral Agents; Choriocarcinoma; Drug Administration Schedule; Neoplasm Transplantation; Organophosphonates; Prodrugs; Rats; Rats, Inbred Strains; Tumor Cells, Cultured | 1998 |
Disposition of the acyclic nucleoside phosphonate (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine.
Topics: Adenine; Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Kidney; Liver; Male; Metabolic Clearance Rate; Organophosphonates; Organophosphorus Compounds; Radiopharmaceuticals; Rats; Rats, Wistar; Tissue Distribution | 1998 |
Genotoxicity of purine acyclic nucleotide analogs.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Female; Guanine; Humans; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Organophosphonates; Organophosphorus Compounds; Purines; Rats; Rats, Inbred BN; Rats, Inbred Lew; Tenofovir; Teratogens; Thioguanine | 1997 |
In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma.
Topics: Adenine; Alkaline Phosphatase; Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Choriocarcinoma; Methotrexate; Organophosphonates; Progesterone; Rats; Rats, Inbred Strains; Stereoisomerism | 1998 |
Antiviral activities of 9-R-2-phosphonomethoxypropyl adenine (PMPA) and bis(isopropyloxymethylcarbonyl)PMPA against various drug-resistant human immunodeficiency virus strains.
Topics: Adenine; Anti-HIV Agents; Dose-Response Relationship, Drug; Drug Resistance, Multiple; HIV; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Virion | 1998 |
Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques.
Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antibodies, Viral; Cesarean Section; Chimera; Drug Administration Schedule; Female; HIV; HIV Infections; Humans; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Pregnancy; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome | 1998 |
Arrest of Trypanosoma brucei rhodesiense and T. brucei brucei in the S-phase of the cell cycle by (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine ((S)-HPMPA).
Topics: Adenine; Animals; Aphidicolin; DNA, Kinetoplast; Organophosphonates; Organophosphorus Compounds; Pyruvates; S Phase; Thymidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense | 1998 |
Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection.
Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antibodies, Viral; Dose-Response Relationship, Drug; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viremia | 1998 |
Human immunodeficiency virus type 1 reverse transcriptase expressing the K70E mutation exhibits a decrease in specific activity and processivity.
Topics: Adenine; Anti-HIV Agents; Cloning, Molecular; Escherichia coli; HIV Reverse Transcriptase; Mutation; Organophosphonates; Poly A; Recombinant Proteins; RNA; Substrate Specificity; Templates, Genetic | 1998 |
Prevention of murine AIDS development by (R)-9-(2-phosphonylmethoxypropyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Survival; Clone Cells; Female; Leukemia Virus, Murine; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Murine Acquired Immunodeficiency Syndrome; Organophosphonates; Organophosphorus Compounds; Specific Pathogen-Free Organisms; Spleen; Tenofovir; Virus Replication; Zidovudine | 1998 |
Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Deoxyadenine Nucleotides; Dideoxynucleotides; DNA Polymerase beta; HIV Reverse Transcriptase; Kinetics; Models, Chemical; Organophosphonates; Organophosphorus Compounds; Rats; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir | 1998 |
Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model.
Topics: Adenine; Alkaline Phosphatase; Animals; Antigens, Neoplasm; Antigens, Surface; Antiviral Agents; Cell Differentiation; Cell Survival; Choriocarcinoma; Drug Therapy, Combination; Enzyme Induction; Growth Inhibitors; Kidney Neoplasms; Methotrexate; Organophosphonates; Organophosphorus Compounds; Progesterone; Rats; Rats, Inbred Strains; Rats, Wistar; Retroviridae; Tenofovir; Trophoblasts; Tumor Cells, Cultured | 1998 |
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
Topics: Adenine; Adenine Nucleotides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Cycloheximide; Dactinomycin; Drug Resistance, Neoplasm; Extracellular Space; Flow Cytometry; Humans; Immunoblotting; Indomethacin; K562 Cells; Mice; Multidrug Resistance-Associated Proteins; Mutation; Organophosphonates; Prodrugs; Protein Synthesis Inhibitors; Sensitivity and Specificity; Temperature; Zidovudine | 1998 |
Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro.
Topics: Adenine; Amino Acid Sequence; Anti-HIV Agents; Baculoviridae; DNA-Directed DNA Polymerase; Drug Resistance; Hepatitis B virus; Humans; Lamivudine; Molecular Sequence Data; Mutation; Organophosphonates; Recombinant Proteins | 1998 |
Inhibition of duck hepatitis B virus replication by 9-(2-phosphonylmethoxyethyl)adenine, an acyclic phosphonate nucleoside analogue.
Topics: Adenine; Animals; Antiviral Agents; Biomarkers; Depression, Chemical; DNA Probes; DNA, Viral; Ducks; Hepatitis B Virus, Duck; Immunoblotting; Immunohistochemistry; In Situ Hybridization; Liver; Organophosphonates; Pancreas; RNA, Viral; Viral Proteins; Virus Replication | 1998 |
Three new drugs for HIV infection.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Central Nervous System Diseases; Cyclopropanes; Dideoxynucleosides; Dizziness; Drug Therapy, Combination; Headache; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors | 1998 |
Capillary electrophoresis separation of the new anti-AIDS agents 9-(2-phosphonylmethoxyethyl)adenine and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine in mixtures with some monoribonucleotides or the most common deoxynucleotides.
Topics: Adenine; Anti-HIV Agents; Electrophoresis, Capillary; Organophosphonates; Ribonucleotides | 1998 |
UV spectroscopy study on complexes of phosphonate ApA analogs with poly(U): promising step in prediction of oligonucleotide analog properties?
Topics: Adenine; Dinucleoside Phosphates; Kinetics; Molecular Structure; Nucleic Acid Conformation; Oligonucleotides; Organophosphonates; Poly U; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thermodynamics | 1998 |
Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).
Topics: Adenine; Animals; Antibodies; Antiviral Agents; Brain; Cell Count; Cells, Cultured; Central Nervous System; Leukocytes; Organophosphonates; RNA Virus Infections; Sheep; Visna-maedi virus | 1998 |
Impact of 9-(2-phosphonylmethoxyethyl)adenine on (deoxy)ribonucleotide metabolism and nucleic acid synthesis in tumor cells.
Topics: Adenine; Animals; Antimetabolites, Antineoplastic; CDC2-CDC28 Kinases; Cyclin A; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Deoxyribonucleotides; DNA, Neoplasm; Humans; Isotope Labeling; K562 Cells; Mice; Molecular Structure; Organophosphonates; Protein Biosynthesis; Protein Serine-Threonine Kinases; Ribonucleotides; RNA; RNA, Neoplasm; S Phase; Thymidine; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1999 |
Early short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine treatment favorably alters the subsequent disease course in simian immunodeficiency virus-infected newborn Rhesus macaques.
Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Humans; Injections, Subcutaneous; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors | 1999 |
Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studies.
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Biological Transport; Body Weight; Female; Immunophenotyping; Macaca mulatta; Maternal-Fetal Exchange; Organophosphonates; Organophosphorus Compounds; Placenta; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Viral Load | 1999 |
9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) therapy prolongs survival of infant macaques inoculated with simian immunodeficiency virus with reduced susceptibility to PMPA.
Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Macaca; Mutation; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Survival Analysis; Tenofovir | 1999 |
Sensitivity of L-(-)2,3-dideoxythiacytidine resistant hepatitis B virus to other antiviral nucleoside analogues.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; DNA-Directed DNA Polymerase; Drug Resistance, Microbial; Drug Resistance, Multiple; Guanine; Hepatitis B virus; Lamivudine; Microbial Sensitivity Tests; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Zalcitabine | 1999 |
Susceptibility of lamivudine-resistant hepatitis B virus to other reverse transcriptase inhibitors.
Topics: Acyclovir; Adenine; Carcinoma, Hepatocellular; Drug Resistance, Microbial; Guanine; Hepatitis B virus; Humans; Lamivudine; Mutagenesis, Site-Directed; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Transfection; Tumor Cells, Cultured | 1999 |
Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates.
Topics: Adenine; Animals; Antimalarials; Cidofovir; Cytosine; Erythrocytes; Ganciclovir; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Plasmodium falciparum; Structure-Activity Relationship | 1999 |
9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.
Topics: Adenine; Annexin A5; Apoptosis; Cell Cycle; Cell Differentiation; Cell Division; Cell Survival; Cyclin A; Cyclin B; Cyclin B1; Cyclin E; DNA Fragmentation; Flow Cytometry; Gene Expression; Growth Inhibitors; Humans; K562 Cells; Molecular Structure; Monocytes; Organophosphonates; Proto-Oncogene Proteins c-myc; RNA, Messenger; S Phase | 1999 |
Activated memory CD4(+) T helper cells repopulate the intestine early following antiretroviral therapy of simian immunodeficiency virus-infected rhesus macaques but exhibit a decreased potential to produce interleukin-2.
Topics: Adenine; Animals; Antiviral Agents; CD11 Antigens; CD4-Positive T-Lymphocytes; Cell Division; Immunologic Memory; Immunophenotyping; Integrin beta1; Interleukin-2; Intestinal Mucosa; Intestine, Small; Longitudinal Studies; Lymphocyte Activation; Lymphocyte Depletion; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load | 1999 |
N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties.
Topics: Adenine; Adenosine Deaminase; Adenosine Triphosphate; AMP Deaminase; Animals; Antineoplastic Agents; Cell Cycle; Cell Differentiation; Cell Division; Deoxyadenine Nucleotides; Drug Interactions; Drug Screening Assays, Antitumor; Erythrocytes; Guanine; Humans; K562 Cells; Leukemia L1210; Mice; Organophosphonates; Organophosphorus Compounds; Pentostatin; Prodrugs; Rats; Tumor Cells, Cultured | 1999 |
9-[2-(Phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases alpha, delta, epsilon, and epsilon*.
Topics: Adenine; Animals; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; DNA Replication; DNA-Directed DNA Polymerase; Organophosphonates; Rats; Rats, Sprague-Dawley; Substrate Specificity | 1999 |
Hydroxyurea enhances the activities of didanosine, 9-[2-(phosphonylmethoxy)ethyl]adenine, and 9-[2-(phosphonylmethoxy)propyl]adenine against drug-susceptible and drug-resistant human immunodeficiency virus isolates.
Topics: Adenine; Anti-HIV Agents; Antineoplastic Agents; Didanosine; DNA, Viral; Drug Resistance, Microbial; HIV Reverse Transcriptase; HIV-1; Humans; Hydroxyurea; Inhibitory Concentration 50; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine | 1999 |
Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
Topics: Adenine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemokine CCL5; Female; Fibrosis; Macrophages, Peritoneal; Nitric Oxide; Organ Size; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Inbred Lew; Spleen; Tenofovir | 1999 |
Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.
Topics: Absorption; Adenine; Animals; Anti-HIV Agents; Biological Transport; Caco-2 Cells; Epithelial Cells; Flavoring Agents; Fruit; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Mouth Mucosa; Organophosphonates; Organophosphorus Compounds; Plant Extracts; Prodrugs; Rats; Swine; Tenofovir | 1999 |
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.
Topics: Adenine; Amino Acid Sequence; Animals; Anion Transport Proteins; Antiviral Agents; Base Sequence; Biological Transport; Carrier Proteins; Cidofovir; Cloning, Molecular; Cytosine; DNA, Complementary; Humans; Immunoblotting; Kidney; Molecular Sequence Data; Nucleosides; Organophosphonates; Organophosphorus Compounds; Rats | 1999 |
Synthesis of a lipophilic prodrug of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and its incorporation into a hepatocyte-specific lipidic carrier.
Topics: Adenine; Animals; Antiviral Agents; Drug Carriers; Drug Delivery Systems; Humans; Lipoproteins, HDL; Lithocholic Acid; Liver; Organophosphonates; Prodrugs; Rats; Tritium | 1999 |
MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.
Topics: Adenine; Anti-HIV Agents; Carrier Proteins; Cell Line; Drug Resistance, Microbial; Gene Amplification; Gene Dosage; Gene Expression; Genes, Dominant; HIV-1; Humans; Hybrid Cells; Inhibitory Concentration 50; Membrane Transport Proteins; Nucleosides; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; RNA, Messenger; T-Lymphocytes; Zidovudine | 1999 |
Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.
Topics: Adenine; Animals; Anti-HIV Agents; Benzylamines; Caco-2 Cells; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Cyclams; Epithelium; Heterocyclic Compounds; Humans; Octanols; Organophosphonates; Organophosphorus Compounds; Rabbits; Solubility; Taurocholic Acid; Tenofovir | 1999 |
9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
Topics: Adenine; Animals; Antineoplastic Agents; Choriocarcinoma; Female; Guanine; Male; Organophosphonates; Organophosphorus Compounds; Pregnancy; Prodrugs; Rats; Tumor Cells, Cultured; Uterine Neoplasms | 1999 |
9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis.
Topics: Adenine; Antineoplastic Agents; Deoxyadenine Nucleotides; DNA; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; Guanine; Humans; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured | 1999 |
Inhibition of adenylyl cyclase by acyclic nucleoside phosphonate antiviral agents.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Antiviral Agents; Brain; Dose-Response Relationship, Drug; Inhibitory Concentration 50; Kinetics; Organophosphonates; Rats; Tenofovir | 1999 |
Fulminant hepatic failure resulting from lamivudine-resistant hepatitis B virus in a renal transplant recipient: durable response after orthotopic liver transplantation on adefovir dipivoxil and hepatitis B immune globulin.
Topics: Adenine; Adult; Antiviral Agents; Carrier State; DNA-Directed DNA Polymerase; Drug Resistance; Female; Hepatitis B; Hepatitis B virus; Humans; Immunization, Passive; Kidney Transplantation; Lamivudine; Liver Failure; Liver Transplantation; Mutation; Organophosphonates | 1999 |
Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques.
Topics: Adenine; Animals; Anti-HIV Agents; Cells, Cultured; HIV Envelope Protein gp120; HIV Reverse Transcriptase; HIV-1; Humans; Lymphocyte Subsets; Macaca mulatta; Membrane Glycoproteins; Organophosphonates; Organophosphorus Compounds; Recombination, Genetic; Reverse Transcriptase Inhibitors; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Envelope Proteins; Viral Load | 2000 |
Prophylactic and therapeutic benefits of short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA.
Topics: Adenine; Administration, Oral; Animals; Animals, Newborn; Antiviral Agents; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Research Design; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2000 |
Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde.
Topics: Acetaldehyde; Adenine; Antiviral Agents; Chemical Precipitation; Chromatography, Liquid; Drug Stability; Fluorescent Dyes; Humans; Indicators and Reagents; Mass Spectrometry; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Trichloroacetic Acid | 1999 |
Carrier-mediated delivery of 9-(2-phosphonylmethoxyethyl)adenine to parenchymal liver cells: a novel therapeutic approach for hepatitis B.
Topics: Adenine; Animals; Antiviral Agents; Chromatography; Drug Carriers; Hepatitis B; Lipoproteins, HDL; Lithocholic Acid; Liver; Male; Organophosphonates; Prodrugs; Rats; Rats, Wistar; Tissue Distribution; Tritium | 2000 |
In vitro antihepadnaviral activities of combinations of penciclovir, lamivudine, and adefovir.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cells, Cultured; Drug Interactions; Drug Therapy, Combination; Ducks; Guanine; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Humans; Lamivudine; Liver; Organophosphonates; Virus Replication | 2000 |
In vitro selection and characterization of HIV-1 with reduced susceptibility to PMPA.
Topics: Adenine; Anti-HIV Agents; Drug Resistance; HIV Reverse Transcriptase; HIV-1; Hydroxyurea; Mutation; Organophosphonates; Organophosphorus Compounds; Tenofovir | 1999 |
Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment.
Topics: Adenine; Animals; Antiviral Agents; Female; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Viral Load | 2000 |
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.
Topics: Adenine; Alanine; Animals; Anion Transport Proteins; Antiviral Agents; Biological Transport; Carrier Proteins; CHO Cells; Cidofovir; Cricetinae; Cytosine; Humans; Kidney; Organophosphate Poisoning; Organophosphonates; Organophosphorus Compounds; Probenecid | 2000 |
Lamivudine, adefovir and tenofovir exhibit long-lasting anti-hepatitis B virus activity in cell culture.
Topics: Acyclovir; Adenine; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Guanine; Hepatitis B virus; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir; Tumor Cells, Cultured | 2000 |
Adefovir dipivoxil. Bis-POM PMEA, GS 0840, GS 840, Piv2PMEA.
Topics: Adenine; Animals; Anti-HIV Agents; Biological Availability; Cytomegalovirus; Cytomegalovirus Infections; Double-Blind Method; Drugs, Investigational; HIV Infections; Humans; Macaca fascicularis; Male; Organophosphonates; Protein Binding; Randomized Controlled Trials as Topic; Semen | 1999 |
Compassionate use for tenofovir.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Drug Approval; HIV Infections; Humans; Organophosphonates; Patient Selection; Tenofovir | 2000 |
Plasmodium falciparum clones resistant to (S)-9-(3-hydroxy-2-phosphonylmethoxy-propyl)adenine carry amino acid substitutions in DNA polymerase delta.
Topics: Adenine; Amino Acid Sequence; Amino Acid Substitution; Animals; Antiparasitic Agents; Binding Sites; DNA-Directed DNA Polymerase; Drug Resistance; Humans; Molecular Sequence Data; Mutation; Organophosphonates; Organophosphorus Compounds; Plasmodium falciparum; Sequence Alignment; Ultraviolet Rays | 2000 |
Inhibition of the replication of the DNA polymerase M550V mutation variant of human hepatitis B virus by adefovir, tenofovir, L-FMAU, DAPD, penciclovir and lobucavir.
Topics: Acyclovir; Adenine; Antiviral Agents; Arabinofuranosylcytosine Triphosphate; Cell Line; Dioxolanes; DNA-Directed DNA Polymerase; DNA, Viral; Guanine; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Purine Nucleosides; Tenofovir; Virus Replication | 2000 |
NDA submitted for adefovir.
Topics: Adenine; Carnitine; Drug Approval; Drug Packaging; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; United States; United States Food and Drug Administration | 1999 |
Effect of PMPA and PMEA on the kinetics of viral load in simian immunodeficiency virus-infected macaques.
Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; Antiviral Agents; Lymph Nodes; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Viral Load | 2000 |
Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiviral Agents; Benzoxazines; Codon; Cohort Studies; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; HIV Infections; Humans; Logistic Models; Male; Middle Aged; Mutation; Organophosphonates; Oxazines; Protease Inhibitors; Retrospective Studies; Reverse Transcriptase Inhibitors; Salvage Therapy; Treatment Outcome; Viral Load | 2000 |
Early HIV infection in vivo: branching-process model for studying timing of immune responses and drug therapy.
Topics: Adenine; Animals; Anti-HIV Agents; Computer Simulation; Disease Progression; HIV; HIV Infections; Humans; Macaca; Macrophages; Models, Immunological; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Soman; Stochastic Processes; Tenofovir; Time Factors; Viral Load | 2000 |
Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates | 2000 |
Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; DNA, Circular; DNA, Viral; Epidermal Growth Factor; Hepatitis B Virus, Woodchuck; Liver; Marmota; Organophosphonates; Virus Replication | 2000 |
Incidental treatment of hepatitis B virus infection in an AIDS patient.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Antiviral Agents; Drug Therapy, Combination; Hepatitis B; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors | 2000 |
In vitro, ex vivo, and in situ intestinal absorption characteristics of the antiviral ester prodrug adefovir dipivoxil.
Topics: Adenine; Animals; Antiviral Agents; Intestinal Absorption; Male; Organophosphonates; Prodrugs; Rats; Rats, Wistar; Verapamil | 2000 |
Promising results for tenofovir.
Topics: Adenine; Clinical Trials, Phase II as Topic; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2000 |
Analogues of amonafide and azonafide with novel ring systems.
Topics: Adenine; Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Humans; Imides; Isoquinolines; Mice; Naphthalimides; Organophosphonates; Phenanthrenes; Structure-Activity Relationship; Tumor Cells, Cultured | 2000 |
Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity.
Topics: Adenine; Animals; Antiviral Agents; Herpesvirus 1, Human; Humans; Liver; Male; Organophosphonates; Prodrugs; Rats; Rats, Wistar; Tritium; Tumor Cells, Cultured | 2000 |
Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.
Topics: Adenine; Anion Transport Proteins; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Biological Transport; Carrier Proteins; Humans; Kidney; Organophosphonates; Structure-Activity Relationship | 2000 |
Efficacy of postexposure prophylaxis after intravaginal exposure of pig-tailed macaques to a human-derived retrovirus (human immunodeficiency virus type 2).
Topics: Acquired Immunodeficiency Syndrome; Adenine; Animals; Anti-HIV Agents; Female; HIV-2; Humans; Macaca nemestrina; Organophosphonates; Organophosphorus Compounds; RNA, Viral; Tenofovir; Vagina | 2000 |
Nucleoside binding site of herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Amino Acid Substitution; Antiviral Agents; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Herpesvirus 1, Human; Mutation; Nucleosides; Organophosphonates; Prodrugs; Protein Structure, Tertiary; Stereoisomerism; Substrate Specificity; Thymidine; Thymidine Kinase; Viral Proteins; Water | 2000 |
Lasting effects of transient postinoculation tenofovir [9-R-(2-Phosphonomethoxypropyl)adenine] treatment on SHIV(KU2) infection of rhesus macaques.
Topics: Adenine; Animals; Anti-HIV Agents; CD4 Lymphocyte Count; Cerebrospinal Fluid; Disease Models, Animal; Kinetics; Lymph Nodes; Macaca mulatta; Male; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Viral Load | 2000 |
The treatment pipeline: new therapies are on the way.
Topics: Adenine; AIDS Vaccines; Anti-HIV Agents; Enfuvirtide; Granulocyte-Macrophage Colony-Stimulating Factor; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; HIV Protease Inhibitors; Humans; Interleukin-2; Organophosphonates; Peptide Fragments; Ritonavir | 1999 |
Post-exposure chemoprophylaxis (PECP) against SIV infection of macaques as a model for protection from HIV infection.
Topics: Adenine; Animals; Disease Models, Animal; DNA, Viral; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Macaca fascicularis; Organophosphonates; Organophosphorus Compounds; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2000 |
Effect of carbonate salts on the kinetics of acid-catalyzed dimerization of adefovir dipivoxil.
Topics: Acids; Adenine; Antiviral Agents; Carbonates; Chemistry, Pharmaceutical; Dimerization; Organophosphonates | 2000 |
Control of SIV rebound through structured treatment interruptions during early infection.
Topics: Adenine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Didanosine; Drug Administration Schedule; Hydroxyurea; Lymphocyte Activation; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Random Allocation; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load; Viremia; Virus Replication | 2000 |
Increased absorption of the antiviral ester prodrug tenofovir disoproxil in rat ileum by inhibiting its intestinal metabolism.
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Chromatography, High Pressure Liquid; Ileum; Intestinal Absorption; Intestinal Mucosa; Mesenteric Arteries; Organophosphonates; Organophosphorus Compounds; Perfusion; Prodrugs; Rats; Tenofovir | 2000 |
Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans.
Topics: Adenine; Animals; Anti-HIV Agents; CD4 Lymphocyte Count; Chimera; Digestive System; Disease Progression; Drug Resistance, Microbial; HIV Infections; HIV-1; Lentivirus Infections; Lymphoid Tissue; Macaca mulatta; Macrophages; Organ Specificity; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Viral; Simian Immunodeficiency Virus; Tenofovir; Viral Load; Virus Replication | 2001 |
Mechanistic study on the cytostatic and tumor cell differentiation-inducing properties of 9-(2-phosphonylmethoxyethyl)adenine (PMEA, adefovir)-collected publications.
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cell Differentiation; Cell Division; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Hepatitis B; HIV Infections; Humans; Neoplasms; Organophosphonates; Rats; Tumor Cells, Cultured | 2000 |
Development of virus-specific immune responses in SHIV(KU)-infected macaques treated with PMPA.
Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; Disease Models, Animal; HIV Antibodies; HIV Infections; HIV-1; Humans; Macaca mulatta; Neutralization Tests; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; Tenofovir; Virus Replication | 2001 |
Enhanced cellular immune response and reduced CD8(+) lymphocyte apoptosis in acutely SIV-infected Rhesus macaques after short-term antiretroviral treatment.
Topics: Adenine; Animals; Anti-HIV Agents; Apoptosis; CD8-Positive T-Lymphocytes; Disease Models, Animal; Humans; Immunologic Memory; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes, Helper-Inducer; Tenofovir; Viral Load | 2001 |
[Antiretroviral therapies].
Topics: Adenine; Alkynes; Antiviral Agents; Benzoxazines; Cyclopropanes; Dioxolanes; Humans; Lipodystrophy; Organophosphonates; Organophosphorus Compounds; Oxazines; Patient Compliance; Protease Inhibitors; Purine Nucleosides; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2000 |
Duck hepatitis B virus polymerase gene mutants associated with resistance to lamivudine have a decreased replication capacity in vitro and in vivo.
Topics: Adenine; Amino Acid Sequence; Antiviral Agents; DNA, Viral; Drug Resistance; Hepatitis B Virus, Duck; Lamivudine; Molecular Sequence Data; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Transcription, Genetic | 2001 |
Efficiency comparisons of rank and permutation tests based on summary statistics computed from repeated measures data.
Topics: Acquired Immunodeficiency Syndrome; Adenine; HIV-1; Humans; Nevirapine; Organophosphonates; Protease Inhibitors; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Statistics as Topic; Viral Load | 2001 |
Pharmacogenetics of anticancer agents: lessons from amonafide and irinotecan.
Topics: Adenine; Antineoplastic Agents; Camptothecin; Humans; Imides; Irinotecan; Isoquinolines; Naphthalimides; Organophosphonates; Pharmacogenetics; Polymorphism, Genetic | 2001 |
[Current treatment of hepatitis B].
Topics: 2-Aminopurine; Adenine; Anti-Inflammatory Agents; Antiviral Agents; DNA Replication; Famciclovir; Forecasting; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Prednisone; Prognosis; Reverse Transcriptase Inhibitors; Time Factors; Virus Replication | 2001 |
Preclinical antitumor activity of the azonafide series of anthracene-based DNA intercalators.
Topics: Adenine; Animals; Antineoplastic Agents; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Imides; Intercalating Agents; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Mice, Nude; Naphthalimides; Neoplasms; Organophosphonates; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2001 |
Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC).
Topics: Acyclovir; Adenine; Amino Acid Sequence; Antiviral Agents; Cytidine Triphosphate; Deoxycytidine; Dideoxynucleotides; Drug Resistance, Microbial; Emtricitabine; Guanine; Hepatitis B virus; Humans; Lamivudine; Models, Molecular; Molecular Sequence Data; Organophosphonates; Protein Conformation; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Homology, Amino Acid | 2001 |
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.
Topics: Adenine; Alanine; Amides; Antiviral Agents; Drug Stability; Esterases; Humans; Nucleotides; Organophosphonates; Organophosphorus Compounds; Phosphoric Acids; Prodrugs; Retroviridae; Structure-Activity Relationship; Tenofovir | 2001 |
CDC to revisit AZT, post-exposure guidelines. Centers for Disease Control and Prevention.
Topics: Adenine; Antiviral Agents; Blood-Borne Pathogens; Centers for Disease Control and Prevention, U.S.; Guidelines as Topic; Health Personnel; HIV Infections; Humans; Macaca; Needlestick Injuries; Occupational Exposure; Organophosphonates; Zidovudine | 1996 |
Update on other antivirals.
Topics: Adenine; Antiviral Agents; Didanosine; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Stavudine; Zalcitabine; Zidovudine | 1996 |
PMPA beats SIV again.
Topics: Adenine; Anemia; Animals; Antiviral Agents; Hemoglobins; Macaca; Organophosphonates; Phosphates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus | 1996 |
Update on antivirals.
Topics: Adenine; Anti-HIV Agents; Brazil; CD4 Lymphocyte Count; Clinical Trials as Topic; Dosage Forms; Drug Resistance, Microbial; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Infusions, Intravenous; Organophosphonates; Organophosphorus Compounds; Saquinavir; Tenofovir; Viral Load | 1997 |
Scientific basis for PEP rests in animal trials.
Topics: Adenine; Animals; Anti-HIV Agents; Centers for Disease Control and Prevention, U.S.; Health Personnel; HIV; HIV Infections; Humans; Macaca; Nevirapine; Occupational Diseases; Organophosphonates; Organophosphorus Compounds; Pan troglodytes; Pyridines; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Tenofovir; United States; Zidovudine | 1997 |
Looking down the drug pipeline.
Topics: Adenine; Animals; Anti-HIV Agents; Biological Availability; Chlorobenzenes; Clinical Trials as Topic; Codon; Dideoxyadenosine; Drug Resistance, Microbial; Drugs, Investigational; Granulocyte-Macrophage Colony-Stimulating Factor; HIV Infections; HIV Protease Inhibitors; Humans; Naphthalenes; Organophosphonates; Pyrimidinones; Receptors, CCR5; Receptors, CXCR4; Reverse Transcriptase Inhibitors; Tenofovir | 1998 |
A rocky road for nucleotide analogs.
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytomegalovirus Retinitis; Cytosine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds | 1998 |
Lower doses of adefovir dipivoxil (Preveon).
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Dose-Response Relationship, Drug; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 1999 |
Expanded access.
Topics: Adenine; Anti-HIV Agents; Carbamates; Drug Approval; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Sulfonamides; Treatment Failure; United States; United States Food and Drug Administration | 1999 |
Upcoming compassionate use programs for two new antiretrovirals will begin this fall.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Drug Approval; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Organophosphonates; Organophosphorus Compounds; Patient Selection; Pyrimidinones; Reverse Transcriptase Inhibitors; Tenofovir | 1999 |
Expanded access.
Topics: Adenine; Anti-HIV Agents; Drug Approval; Drugs, Investigational; Health Services Accessibility; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Reverse Transcriptase Inhibitors; Tenofovir | 1999 |
CRIA clinical trials.
Topics: Adenine; Alkynes; Anabolic Agents; Anti-HIV Agents; Benzoxazines; Blood Glucose; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Male; Organophosphonates; Oxandrolone; Oxazines; Patient Selection; Reverse Transcriptase Inhibitors; Weight Loss | 1998 |
[Once daily administration improves therapy adherence in HAART. New substance class with more powerful reserves against virus resistance].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Administration Schedule; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2001 |
Erythrocyte-mediated delivery of a new homodinucleotide active against human immunodeficiency virus and herpes simplex virus.
Topics: Adenine; Antiviral Agents; Carbon Radioisotopes; Drug Delivery Systems; Erythrocytes; Herpesvirus 1, Human; HIV-1; Humans; Macrophages; Microbial Sensitivity Tests; Organophosphonates | 2001 |
Degradation kinetics of oxycarbonyloxymethyl prodrugs of phosphonates in solution.
Topics: Adenine; Hydrolysis; Kinetics; Organophosphonates; Organophosphorus Compounds; Prodrugs; Solutions | 2001 |
Formation of ternary complexes by coordination of (diethylenetriamine)-platinum(II) to N1 or N7 of the adenine moiety of the antiviral nucleotide analogue 9.
Topics: Adenine; Antiviral Agents; Binding Sites; Chelating Agents; Drug Stability; Hydrogen-Ion Concentration; Metals, Heavy; Organophosphonates; Organoplatinum Compounds; Polyamines | 2001 |
Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection.
Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; DNA, Viral; Humans; Lymphocyte Activation; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Proviruses; Reverse Transcriptase Inhibitors; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2001 |
Tenofovir ready for approval.
Topics: Adenine; Anti-HIV Agents; Drug Approval; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; United States; United States Food and Drug Administration | 2001 |
Adefovir nephrotoxicity: possible role of mitochondrial DNA depletion.
Topics: Acute Kidney Injury; Adenine; Adult; Antiviral Agents; Cytochrome-c Oxidase Deficiency; Dissection; DNA, Mitochondrial; Drug Therapy, Combination; Electron Transport Complex IV; HIV Infections; Humans; Immunoenzyme Techniques; Kidney Tubules, Proximal; Male; Micromanipulation; Mitochondria; Necrosis; Organophosphonates; Polymerase Chain Reaction; Succinate Dehydrogenase | 2001 |
In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Dioxolanes; Drug Resistance, Microbial; Hepatitis B virus; Humans; Lamivudine; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Organophosphonates; Purine Nucleosides; Transfection; Tumor Cells, Cultured; Virus Replication | 2001 |
Carrier-mediated delivery improves the efficacy of 9-(2-phosphonylmethoxyethyl)adenine against hepatitis B virus.
Topics: Adenine; Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Drug Delivery Systems; Hepatitis B virus; Humans; Lactose; Lipoproteins, HDL; Lithocholic Acid; Microbial Sensitivity Tests; Organophosphonates; Tumor Cells, Cultured; Virus Replication | 2001 |
Antiretroviral agents restore Mycobacterium-specific T-cell immune responses and facilitate controlling a fatal tuberculosis-like disease in Macaques coinfected with simian immunodeficiency virus and Mycobacterium bovis BCG.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; HIV Protease Inhibitors; Indinavir; Macaca mulatta; Macaca nemestrina; Mycobacterium bovis; Nelfinavir; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir; Tuberculosis | 2001 |
Successful treatment with adefovir dipivoxil in a patient with fibrosing cholestatic hepatitis and lamivudine resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; Drug Resistance, Microbial; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis, Biliary; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Occupational Diseases; Organophosphonates; Treatment Outcome | 2001 |
Tenofovir, adefovir, and zidovudine susceptibilities of primary human immunodeficiency virus type 1 isolates with non-B subtypes or nucleoside resistance.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Microbial; HIV Infections; HIV-1; Humans; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2001 |
Encouraging results for tenofovir.
Topics: Adenine; Clinical Trials, Phase III as Topic; HIV Infections; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2001 |
Safety and efficacy of adefovir dipivoxil in patients co-infected with HIV-1 and lamivudine-resistant hepatitis B virus: an open-label pilot study.
Topics: Adenine; Adult; Alanine Transaminase; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Microbial; Female; Hepatitis B; Hepatitis B virus; HIV Infections; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Pilot Projects; Viral Load | 2001 |
Antiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks.
Topics: Adenine; Administration, Oral; Animals; Chemistry, Clinical; Chronic Disease; Disease Models, Animal; DNA, Viral; Hepatitis B; Hepatitis B Virus, Woodchuck; Liver; Marmota; Organophosphonates; Treatment Outcome | 2001 |
Tenofovir: Gilead applies for approval; expanded access liberalized.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Approval; Drug Industry; Health Services Accessibility; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration; Viral Load | 2001 |
Tenofovir: FDA hearing October 3, public comment deadlines September 26.
Topics: Adenine; Anti-HIV Agents; Drug Approval; Drug Resistance, Microbial; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Patient Compliance; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2001 |
Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment.
Topics: Adenine; Animals; Anti-HIV Agents; CD8-Positive T-Lymphocytes; Female; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Virus Replication | 2001 |
Nucleoside phosphonate interactions with multiple organic anion transporters in renal proximal tubule.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Fluorescent Dyes; Fundulidae; In Vitro Techniques; Kidney Tubules, Proximal; Membrane Transport Proteins; Microscopy, Confocal; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Organophosphorus Compounds; Probenecid; Renal Agents; Xenobiotics | 2001 |
Prevention and inhibition of nasopharyngeal carcinoma growth by antiviral phosphonated nucleoside analogs.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Carcinoma; Cell Division; Cidofovir; Cytosine; Epithelial Cells; Growth Inhibitors; Herpesvirus 4, Human; Humans; Mice; Mice, Nude; Nasopharyngeal Neoplasms; Organophosphonates; Organophosphorus Compounds; Tenofovir; Xenograft Model Antitumor Assays | 2001 |
Tenofovir: FDA hearing on important new antiretroviral.
Topics: Adenine; Drug Approval; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2001 |
Activation by 9-(R)-[2-(phosphonomethoxy)propyl]adenine of chemokine (RANTES, macrophage inflammatory protein 1alpha) and cytokine (tumor necrosis factor alpha, interleukin-10 [IL-10], IL-1beta) production.
Topics: Adenine; Animals; Anti-HIV Agents; Cells, Cultured; Chemokine CCL4; Chemokine CCL5; Chemokines; Cytokines; Female; Interleukin-1; Interleukin-10; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; Tenofovir; Tumor Necrosis Factor-alpha | 2001 |
Acute liver graft failure due to emergence of lamivudine resistant hepatitis B virus: rapid resolution during treatment with adefovir.
Topics: Acute Disease; Adenine; Adult; Anti-HIV Agents; Drug Resistance, Viral; Graft Rejection; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Immunoglobulins, Intravenous; Immunohistochemistry; Lamivudine; Liver; Liver Transplantation; Male; Organophosphonates | 2001 |
Tenacious tenofovir struts its stuff in a virtual ICAAC.
Topics: Adenine; Clinical Trials as Topic; Drug Interactions; Drug Resistance, Microbial; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2001 |
From the Food and Drug Administration.
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Cathartics; Defibrillators, Implantable; HIV Infections; HIV-1; Humans; Monitoring, Ambulatory; Organophosphonates; Organophosphorus Compounds; Pacemaker, Artificial; Pharmaceutical Solutions; Phosphates; Tenofovir; United States; United States Food and Drug Administration; Viral Load; Water-Electrolyte Imbalance | 2001 |
Expanded access to tenofovir.
Topics: Adenine; Canada; Europe; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; United States | 2001 |
Tenofovir approved: broad indication.
Topics: Adenine; Drug Approval; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2001 |
Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status.
Topics: Adenine; Animals; Antibodies, Viral; Antiviral Agents; Blood Transfusion, Autologous; CD4-Positive T-Lymphocytes; Combined Modality Therapy; Disease Progression; DNA, Viral; Immunotherapy, Adoptive; Leukocytes, Mononuclear; Macaca mulatta; Neutralization Tests; Organophosphonates; Organophosphorus Compounds; Proviruses; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Tenofovir; Viral Load | 2002 |
Inhibitory effect of adefovir on viral DNA synthesis and covalently closed circular DNA formation in duck hepatitis B virus-infected hepatocytes in vivo and in vitro.
Topics: Adenine; Animals; Antiviral Agents; Disease Models, Animal; DNA, Circular; DNA, Viral; Ducks; Hepatitis B; Hepatitis B Virus, Duck; Hepatocytes; Organophosphonates | 2002 |
Prodrug of tenofovir diphosphate approved for combination HIV therapy.
Topics: Adenine; Anti-HIV Agents; Biological Availability; Drug Approval; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Prodrugs; Tenofovir; United States; United States Food and Drug Administration | 2002 |
Assessment of mitochondrial toxicity in human cells treated with tenofovir: comparison with other nucleoside reverse transcriptase inhibitors.
Topics: Adenine; Cells, Cultured; DNA, Mitochondrial; Electron Transport Complex IV; Humans; Immunoblotting; Kidney Tubules, Proximal; Lactic Acid; Liver; Mitochondria; Muscle, Skeletal; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Tumor Cells, Cultured | 2002 |
Tenofovir (viread) receives FDA approval.
Topics: Adenine; Drug Approval; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2002 |
More uses for tenofovir?
Topics: Adenine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2001 |
Nutrient deficiency associated with new HIV medication.
Topics: Adenine; HIV Infections; Humans; Nutrition Disorders; Organophosphonates; Organophosphorus Compounds; Phosphorus; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
Gilead sciences releases Viread.
Topics: Adenine; Drug Approval; Drug Industry; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2002 |
Fetal and maternal outcome after administration of tenofovir to gravid rhesus monkeys (Macaca mulatta).
Topics: Adenine; Animals; Anti-HIV Agents; Body Weight; Bone and Bones; Embryonic and Fetal Development; Female; Fetus; Gravidity; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Pregnancy; Pregnancy Outcome; Reverse Transcriptase Inhibitors; Somatomedins; Tenofovir | 2002 |
Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.
Topics: Adenine; Anti-HIV Agents; Antigens, CD34; Cell Line; Didanosine; Dideoxynucleosides; Epithelial Cells; Hematopoietic Stem Cells; Humans; Kidney Tubules, Proximal; Liver; Muscle, Skeletal; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Tumor Cells, Cultured; Zalcitabine; Zidovudine | 2002 |
FDA approves tenofovir.
Topics: Adenine; Drug Approval; HIV Seropositivity; Humans; Organophosphonates; Organophosphorus Compounds; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2002 |
Use of tenofovir.
Topics: Adenine; Clinical Trials as Topic; HIV Seropositivity; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2002 |
Phenotypic susceptibilities to tenofovir in a large panel of clinically derived human immunodeficiency virus type 1 isolates.
Topics: Adenine; Drug Resistance, Microbial; Genotype; HIV-1; Humans; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir | 2002 |
New antiretroviral for HIV infection.
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2002 |
Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy.
Topics: Adenine; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Foscarnet; Herpes Genitalis; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2002 |
Human immunodeficiency virus (HIV) Type 1 reverse transcriptase resistance mutations in hepatitis B virus (HBV)-HIV-coinfected patients treated for HBV chronic infection once daily with 10 milligrams of adefovir dipivoxil combined with lamivudine.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors | 2002 |
Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*.
Topics: Adenine; Animals; Anti-HIV Agents; DNA Polymerase I; DNA Polymerase II; DNA Polymerase III; DNA-Directed DNA Polymerase; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Organophosphorus Compounds; Rats; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
Raman spectroscopy study of acid-base and structural properties of 9-[2-(phosphonomethoxy)ethyl]adenine in aqueous solutions.
Topics: Acids; Adenine; Crystallography, X-Ray; Hydrogen-Ion Concentration; Models, Chemical; Organophosphonates; Protein Conformation; Spectrum Analysis, Raman | 2002 |
[Tenofovir--a new option for combination therapy].
Topics: Adenine; Anti-HIV Agents; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2002 |
[Nucleotide analog shows effectiveness in previously treated patients. The new kind of HAART].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Clinical Trials as Topic; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; Viral Load | 2002 |
[No comparison with NRTI. Tenofovir is robust against resistance trouble].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Drug Resistance, Viral; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2002 |
[First nucleotide analog on the market. New drug for the pretreated patient].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Drug Approval; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2002 |
Drugs in development.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Cyclic N-Oxides; HIV Infections; Humans; Nitriles; Organophosphonates; Organophosphorus Compounds; Oximes; Piperidines; Pyridazines; Pyridines; Pyrimidines; Tenofovir | 2002 |
ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase.
Topics: Adenine; Adenosine Triphosphate; Anti-HIV Agents; Catalysis; Drug Resistance, Viral; HIV Reverse Transcriptase; Mutation; Organophosphonates; Organophosphorus Compounds; Recombinant Proteins; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Virus Replication; Zidovudine | 2002 |
Characterizing antiviral activity of adefovir dipivoxil in transgenic mice expressing hepatitis B virus.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Disease Models, Animal; DNA, Viral; Dose-Response Relationship, Drug; Hepatitis B; Hepatitis B virus; Lamivudine; Liver; Mice; Mice, Transgenic; Organophosphonates; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; RNA, Viral; Time Factors; Viral Load | 2002 |
Dose proportional inhibition of HIV-1 replication by mycophenolic acid and synergistic inhibition in combination with abacavir, didanosine, and tenofovir.
Topics: Adenine; Cells, Cultured; Didanosine; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Enzyme Inhibitors; HIV-1; Humans; Leukocytes, Mononuclear; Mycophenolic Acid; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2002 |
8th European Conference on Clinical Aspects and Treatment of HIV Infection, Athens, 28-31 October 2001.
Topics: Adenine; Anti-HIV Agents; Greece; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2002 |
Vaccines. Monkey puzzles.
Topics: Acquired Immunodeficiency Syndrome; Adenine; AIDS Vaccines; Animals; Anti-HIV Agents; Clinical Trials as Topic; Haplorhini; HIV; Humans; Killer Cells, Natural; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; SAIDS Vaccines; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viremia | 2002 |
Adefovir nephrotoxicity and mitochondrial DNA depletion.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase III as Topic; Cyclooxygenase Inhibitors; DNA, Mitochondrial; Drug Therapy, Combination; HIV Infections; Humans; Hydroxyurea; Kidney Tubules; Mitochondria; Organophosphonates; Renal Insufficiency; Stavudine | 2002 |
Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.
Topics: Adenine; Adjuvants, Pharmaceutic; Animals; Biological Transport; Caco-2 Cells; Cyclosporine; Drug Stability; Esters; Fragaria; Humans; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Organophosphonates; Organophosphorus Compounds; Plant Extracts; Prodrugs; Rats; Tenofovir | 2002 |
Promising new agents on the horizon.
Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Clinical Trials as Topic; HIV Infections; HIV Protease Inhibitors; Humans; Nitriles; Oligopeptides; Organophosphonates; Organophosphorus Compounds; Pyridazines; Pyridines; Pyrimidines; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2002 |
Tenofovir treatment in patients with lamivudine-resistant hepatitis B mutants strongly affects viral replication.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2002 |
Tenofovir DF expanded access. Criteria for U.S. program.
Topics: Adenine; Drug Approval; Europe; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2001 |
Antiretroviral news from ICAAC 2000.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Drug Administration Schedule; Drug Resistance; HIV Infections; Humans; Lopinavir; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Ritonavir; Tenofovir | 2000 |
New antiretroviral agents.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Carbamates; Deoxycytidine; Dioxolanes; Drugs, Investigational; Emtricitabine; Furans; Guanosine; HIV Fusion Inhibitors; Humans; Imidazoles; Oligopeptides; Organophosphates; Organophosphonates; Organophosphorus Compounds; Prodrugs; Protease Inhibitors; Pyridines; Pyrones; Quinazolines; Reverse Transcriptase Inhibitors; Sulfonamides; Sulfur Compounds; Tenofovir | 2001 |
Pharmacokinetic and antiretroviral activity in mice of oral [P(1),P(2)-bis[2-(adenin-9-yl)ethoxymethyl]phosphonate], a prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Biological Availability; Blood Cell Count; Chromatography, High Pressure Liquid; Disease Models, Animal; DNA, Viral; Female; Humans; Injections, Intraperitoneal; Lymph Nodes; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Organophosphonates; Polymerase Chain Reaction; Prodrugs; Retroviridae; Retroviridae Infections; Tumor Cells, Cultured | 2002 |
Tenofovir gel studied.
Topics: Adenine; Anti-HIV Agents; Clinical Trials, Phase I as Topic; Female; Gels; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; United States | 2002 |
Highlights of the 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC).
Topics: Adenine; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Drug Administration Schedule; Drug Combinations; Drug Resistance, Microbial; Drug Therapy; Epoetin Alfa; Erythropoietin; Hepatitis C; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Recombinant Proteins; Saquinavir; Tenofovir; Zidovudine | 2002 |
Anti-HIV agents. Tenofovir looks good in initial therapy.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Humans; Lipids; Organophosphonates; Organophosphorus Compounds; Tenofovir; Treatment Outcome; Viral Load | 2002 |
Anti-HIV agents. Tenofovir and Videx (ddi) EC--some caution required.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Didanosine; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2002 |
New drugs 2002, part III.
Topics: Adenine; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Antihypertensive Agents; Antirheumatic Agents; Bone Resorption; Bosentan; Cephalosporins; Darbepoetin alfa; Diphosphonates; Drug Approval; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Erythropoietin; Heart Failure; Humans; Hypoglycemic Agents; Imidazoles; Indoles; Insulin; Insulin Aspart; Interleukin 1 Receptor Antagonist Protein; Natriuretic Agents; Natriuretic Peptide, Brain; Organophosphonates; Organophosphorus Compounds; Protein C; Recombinant Proteins; Serotonin Receptor Agonists; Sialoglycoproteins; Sulfonamides; Tenofovir; Tryptamines; Zoledronic Acid | 2002 |
Treatment of recurrent hepatitis B infection in liver transplant recipients.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Famciclovir; Hepatitis B; Humans; Interferon-alpha; Lamivudine; Liver Transplantation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2002 |
The prevalence and determinants of the K65R mutation in HIV-1 reverse transcriptase in tenofovir-naive patients.
Topics: Adenine; Anti-HIV Agents; Databases, Factual; Dideoxynucleosides; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Organophosphorus Compounds; Prevalence; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
[First nucleotide analog against HIV. Lowers viral load also in drug resistance].
Topics: Adenine; Anti-HIV Agents; Clinical Trials, Phase II as Topic; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
[Tenofovir in Study 903. Also effective and tolerable in first-line therapy].
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Treatment Outcome; Viral Load | 2002 |
Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures.
Topics: Adenine; Antiviral Agents; Cell Survival; Epithelial Cells; Humans; Keratinocytes; Models, Theoretical; Molecular Weight; Nucleosides; Organ Culture Techniques; Organophosphonates; Organophosphorus Compounds; Structure-Activity Relationship; Vaccinia; Vaccinia virus | 2002 |
Marked elevation of the creatine phosphokinase level in a patient receiving tenofovir.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Creatine Kinase; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2002 |
Phenotypic and genotypic HIV-1 drug resistance assays provide complementary information.
Topics: Adenine; Anti-HIV Agents; Carbamates; Didanosine; Dideoxynucleosides; Drug Resistance, Viral; Furans; Genotype; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Sulfonamides; Tenofovir; Zalcitabine | 2002 |
Topical administration of low-dose tenofovir disoproxil fumarate to protect infant macaques against multiple oral exposures of low doses of simian immunodeficiency virus.
Topics: Adenine; Administration, Topical; Animals; Anti-HIV Agents; Disease Models, Animal; Macaca; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2002 |
Inhibition of murine AIDS by a heterodinucleotide of azidothymidine and 9-(R)-2-(phosphonomethoxypropyl)adenine.
Topics: Adenine; Animals; Area Under Curve; Chemistry, Pharmaceutical; Drug Combinations; Mice; Mice, Inbred ICR; Murine Acquired Immunodeficiency Syndrome; Organophosphonates; Organophosphorus Compounds; Prodrugs; Tenofovir; Zidovudine | 2002 |
Editorial comment: a tale of two viruses.
Topics: Adenine; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Vaccines; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells.
Topics: Adenine; Anti-HIV Agents; Cell Line; Cells, Cultured; Dendritic Cells; Humans; Lamivudine; Langerhans Cells; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; T-Lymphocytes; Tenofovir; Zidovudine | 2002 |
FDA notifications. New treatment approved for chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Drug Approval; Hepatitis B, Chronic; Humans; Kidney; Organophosphonates; United States; United States Food and Drug Administration | 2002 |
From the Food and Drug Administration.
Topics: Adenine; Anastrozole; Antineoplastic Agents, Hormonal; Antiviral Agents; Breast Neoplasms; Chemotherapy, Adjuvant; Hepatitis B, Chronic; Humans; Nitriles; Organophosphonates; Triazoles; United States; United States Food and Drug Administration | 2002 |
FDA recommends hepatitis B drug.
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Drug Approval; Hepatitis B; Humans; Kidney Diseases; Organophosphonates; United States; United States Food and Drug Administration | 2002 |
Would switching the protease inhibitors (PI) to tenoforvir be an option in controlling hypertriglyceridaemia secondary to PIs? A case report.
Topics: Adenine; HIV Infections; HIV Protease Inhibitors; Humans; Hypertriglyceridemia; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
Fanconi syndrome and renal failure induced by tenofovir: a first case report.
Topics: Adenine; Anti-HIV Agents; Fanconi Syndrome; Female; HIV Seropositivity; Humans; Middle Aged; Organophosphonates; Organophosphorus Compounds; Renal Insufficiency; Tenofovir | 2002 |
Tenofovir treatment at 30 mg/kg/day can inhibit cortical bone mineralization in growing rhesus monkeys (Macaca mulatta).
Topics: Adenine; Animals; Bone Remodeling; Calcification, Physiologic; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Tibia | 2002 |
Adefovir (Hepsera) for chronic hepatitis B infection.
Topics: Adenine; Administration, Oral; Controlled Clinical Trials as Topic; Creatinine; Drug Resistance, Viral; Economics, Pharmaceutical; Fees, Pharmaceutical; Hepatitis B, Chronic; Humans; Kidney Diseases; Organophosphonates; Urine | 2002 |
Tenofovir DF trial announced by Gilead.
Topics: Adenine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2000 |
Prevention: new approach will test tenofovir for persons at high risk.
Topics: Adenine; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir | 2002 |
Rapid communication: acute renal failure associated with tenofovir: evidence of drug-induced nephrotoxicity.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Chronic Disease; HIV Infections; Humans; Kidney; Kidney Diseases; Male; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2002 |
Effect of the G1896A precore mutation on drug sensitivity and replication yield of lamivudine-resistant HBV in vitro.
Topics: Adenine; Baculoviridae; Carcinoma, Hepatocellular; Drug Resistance, Viral; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; In Vitro Techniques; Lamivudine; Liver Neoplasms; Organophosphonates; Point Mutation; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured; Virus Replication | 2003 |
Reversion of the M184V mutation in simian immunodeficiency virus reverse transcriptase is selected by tenofovir, even in the presence of lamivudine.
Topics: Adenine; Base Sequence; Cell Line; DNA Primers; Drug Resistance, Viral; Lamivudine; Mutagenesis, Site-Directed; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Simian Immunodeficiency Virus; Tenofovir | 2003 |
Tenofovir disoproxil fumarate in patients with HIV and lamivudine-resistant hepatitis B virus.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Predominance of pre-S1 mutated hepatitis B virus in a patient following treatment with adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Drug Resistance, Microbial; Gene Deletion; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Mutation; Organophosphonates; Protein Precursors; Reverse Transcriptase Inhibitors; Salvage Therapy | 2003 |
Successful treatment of fibrosing cholestatic hepatitis using adefovir dipivoxil in a patient with cirrhosis and renal insufficiency.
Topics: Adenine; Adult; Antiviral Agents; Bacterial Infections; Cholestasis; Drug Resistance, Microbial; Fibrosis; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver; Liver Cirrhosis; Male; Organophosphonates; Peritonitis; Recurrence; Renal Insufficiency; Reverse Transcriptase Inhibitors | 2003 |
Determination of tenofovir in human plasma by high-performance liquid chromatography with spectrofluorimetric detection.
Topics: Adenine; Calibration; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Organophosphonates; Organophosphorus Compounds; Reference Standards; Reproducibility of Results; Reverse Transcriptase Inhibitors; Spectrometry, Fluorescence; Tenofovir | 2003 |
Tenofovir disoproxil fumarate exhibits strong antiviral effect in a patient with lamivudine-resistant severe hepatitis B reactivation.
Topics: Adenine; Antiviral Agents; Drug Resistance, Microbial; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir; Virus Activation | 2003 |
Comparative effects of adefovir and selected nucleoside inhibitors of hepatitis B virus DNA polymerase on mitochondrial DNA in liver and skeletal muscle cells.
Topics: Adenine; Antiviral Agents; DNA, Mitochondrial; Hepatitis B virus; Hepatitis B, Chronic; Hepatoblastoma; Humans; Mitochondria, Liver; Muscle, Skeletal; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Tumor Cells, Cultured | 2003 |
Tenofovir (Viread(R)) access for poor countries.
Topics: Adenine; Developing Countries; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
Antiviral effect of adefovir in combination with a DNA vaccine in the duck hepatitis B virus infection model.
Topics: Adenine; Animals; Antibody Formation; Antiviral Agents; Ducks; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Immunization; Liver; Organophosphonates; Vaccines, DNA; Viremia; Virus Replication | 2003 |
Suppressing hepatitis B without resistance--so far, so good.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Organophosphonates | 2003 |
Tenofovir helps beat hepatitis B.
Topics: Adenine; Antiviral Agents; CD4 Lymphocyte Count; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Male; Organophosphonates; Organophosphorus Compounds; Tenofovir; Viral Load | 2003 |
Unsuccessful rescue therapy with adefovir dipivoxil for lamivudine resistant HBV in a patient with liver failure.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Fatal Outcome; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Failure, Acute; Middle Aged; Organophosphonates; Salvage Therapy | 2003 |
Rapid hepatitis B virus-DNA decay in co-infected HIV-hepatitis B virus 'e-minus' patients with YMDD mutations after 4 weeks of tenofovir therapy.
Topics: Adenine; Adult; Anti-HIV Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
New uses for tenofovir: more questions about d4T.
Topics: Adenine; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir | 2003 |
Renal lesions in HIV-1-positive patient treated with tenofovir.
Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Tenofovir-related nephrotoxicity in human immunodeficiency virus-infected patients: three cases of renal failure, Fanconi syndrome, and nephrogenic diabetes insipidus.
Topics: Acidosis; Adenine; Adult; Anti-HIV Agents; Creatinine; Diabetes Insipidus, Nephrogenic; Drug Monitoring; Fanconi Syndrome; Glycosuria; HIV Infections; Humans; Middle Aged; Organophosphonates; Organophosphorus Compounds; Proteinuria; Renal Insufficiency; Tenofovir | 2003 |
Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Didanosine; Drug Synergism; Fatal Outcome; Humans; Male; Middle Aged; Mitochondria; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine.
Topics: Adenine; Adenosine Triphosphate; Animals; Antineoplastic Agents; Antiviral Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cell Membrane; Colforsin; Coloring Agents; Cyclic AMP; Cyclic GMP; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance; Floxuridine; Fluorouracil; Genetic Vectors; Growth Inhibitors; Immunoblotting; Inhibitory Concentration 50; Insecta; Models, Biological; Nitrosamines; Nucleotides; Organophosphonates; Swine; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Zalcitabine | 2003 |
Evaluation of mitochondrial DNA content and enzyme levels in tenofovir DF-treated rats, rhesus monkeys and woodchucks.
Topics: Adenine; Animals; Citrate (si)-Synthase; DNA, Mitochondrial; Electron Transport Complex IV; Macaca mulatta; Marmota; Mitochondria; Organ Specificity; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Species Specificity; Tenofovir | 2003 |
Manufacturer end adefovir development.
Topics: Adenine; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2000 |
[Tenofovir (Viread)].
Topics: Adenine; Anti-HIV Agents; Drug Interactions; Drug Resistance, Viral; HIV; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2002 |
[96-week treatment outcome confirms long term efficacy of tenofovir DF].
Topics: Adenine; Anti-HIV Agents; Drug Therapy, Combination; HIV Infections; Humans; Multicenter Studies as Topic; Organophosphonates; Organophosphorus Compounds; Randomized Controlled Trials as Topic; Tenofovir; Time Factors; Treatment Outcome | 2003 |
[Determination of adefovir in monkey plasma by liquid chromatography-tandem mass spectrometry].
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Chromatography, Liquid; Macaca mulatta; Organophosphonates; Spectrometry, Mass, Electrospray Ionization | 2003 |
HIV-1 resistance profile of the novel nucleoside reverse transcriptase inhibitor beta-D-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine (Reverset).
Topics: Adenine; Anti-HIV Agents; Cell Line; Cytidine Triphosphate; Didanosine; Drug Resistance, Multiple, Viral; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Species Specificity; Tenofovir; Transfection; Zalcitabine; Zidovudine | 2003 |
Liquid chromatographic assay for the antiviral nucleotide analogue tenofovir in plasma using derivatization with chloroacetaldehyde.
Topics: Acetaldehyde; Adenine; Chromatography, Liquid; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reproducibility of Results; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Spectrometry, Fluorescence; Tenofovir | 2003 |
Adefovir dipivoxil for hepatitis B e antigen-positive chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Placebos; Research Design | 2003 |
Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells.
Topics: Adenine; Anti-HIV Agents; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media; Didanosine; Drug Interactions; Humans; Leukocytes, Mononuclear; Organophosphonates; Organophosphorus Compounds; Phosphorylation; Tenofovir | 2003 |
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Humans; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Poxviridae Infections; Prodrugs; Skin; Tenofovir; Virus Replication | 2003 |
Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.
Topics: Adenine; Animals; Capsid; Combined Modality Therapy; Disease Models, Animal; Gene Expression Regulation, Viral; Genetic Therapy; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Lamivudine; Liver; Male; Mice; Mice, Inbred Strains; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Small Interfering; Specific Pathogen-Free Organisms; Virus Replication | 2003 |
Pancreatitis in an HIV-infected person on a tenofovir, didanosine and stavudine containing highly active antiretroviral treatment.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Didanosine; Drug Interactions; Female; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Pancreatitis; Ritonavir; Stavudine; Tenofovir | 2003 |
Antiviral Research--16th Annual International Conference. Satellite symposium: clinical update on antiviral drugs. 27 April-1 May 2003, Savannah, GA, USA.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Enfuvirtide; Ganciclovir; Hepatitis B; HIV Envelope Protein gp41; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Peptide Fragments; Tenofovir; Valganciclovir | 2003 |
[The first nucleotide analog permitted. New hepatitis B therapy helps the problem patients, too].
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Drug Resistance; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Liver Transplantation; Organophosphonates; Placebos; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors | 2003 |
Susceptibility of human T cell leukemia virus type I to nucleoside reverse transcriptase inhibitors.
Topics: Adenine; Cell Line; Dideoxynucleosides; Human T-lymphotropic virus 1; Humans; Lamivudine; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Virus Replication; Zalcitabine; Zidovudine | 2003 |
Acute renal failure associated with tenofovir treatment in a patient with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adenine; Anti-HIV Agents; HIV; Humans; Kidney Tubular Necrosis, Acute; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Tenofovir; Viral Load | 2003 |
Fatal lactic acidosis and mimicking Guillain-Barré syndrome in an adolescent with human immunodeficiency virus infection.
Topics: Acidosis, Lactic; Adenine; Adolescent; Antiretroviral Therapy, Highly Active; Carbamates; Diagnosis, Differential; Didanosine; Disease Progression; Drug Therapy, Combination; Fatal Outcome; Female; Furans; Guillain-Barre Syndrome; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Organophosphonates; Organophosphorus Compounds; Risk Assessment; Severity of Illness Index; Stavudine; Sulfonamides; Tenofovir | 2003 |
Tenofovir disoproxil fumarate.
Topics: Adenine; Anti-HIV Agents; Drug Administration Schedule; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Kidney Diseases; Mutation; Organophosphonates; Organophosphorus Compounds; Tenofovir; Time Factors | 2003 |
Tenofovir disoproxil fumarate.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Viral; Drug Synergism; Gastrointestinal Diseases; HIV Infections; HIV-1; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Resistance to adefovir dipivoxil therapy associated with the selection of a novel mutation in the HBV polymerase.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Viral Proteins | 2003 |
Preemptive use of antiretroviral drugs to prevent sexual transmission of HIV to high-risk uninfected MSM.
Topics: Adenine; Anti-HIV Agents; Centers for Disease Control and Prevention, U.S.; Clinical Trials as Topic; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Organophosphorus Compounds; Politics; Research Support as Topic; Tenofovir; United States | 2003 |
The acyclic nucleoside phosphonate analogues, adefovir, tenofovir and PMEDAP, efficiently eliminate banana streak virus from banana (Musa spp.).
Topics: Adenine; Antiviral Agents; Badnavirus; Musa; Organophosphonates; Organophosphorus Compounds; Plant Diseases; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2003 |
[New option for successful therapy of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Approval; Germany; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2003 |
Sensitive determination of tenofovir in human plasma samples using reversed-phase liquid chromatography.
Topics: Adenine; Chromatography, High Pressure Liquid; Drug Monitoring; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reproducibility of Results; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tenofovir | 2003 |
Pharmacokinetics of tenofovir in haemodialysis.
Topics: Adenine; Anti-HIV Agents; Humans; Kidney Failure, Chronic; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Renal Dialysis; Tenofovir | 2003 |
Pancreatitis with didanosine and tenofovir disoproxil fumarate [corrected].
Topics: Adenine; Adult; Didanosine; Drug Interactions; Fatal Outcome; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Pancreatitis; Tenofovir | 2003 |
Tenofovir, COX inhibitors and zileuton during cancer immunotherapies: up-regulated TNF-alpha increases antigen driven lymphocyte proliferation.
Topics: Adenine; Adenylyl Cyclases; Anti-HIV Agents; Cell Division; Cyclooxygenase Inhibitors; Humans; Hydroxyurea; Immunotherapy; Lipoxygenase Inhibitors; Lymphocytes; Neoplasms; Organophosphonates; Organophosphorus Compounds; Tenofovir; Tumor Necrosis Factor-alpha; Up-Regulation | 2003 |
[HIV therapy: tenofir DF is available in 68 developing countries at production costs price].
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Developing Countries; Drug Costs; Drug Industry; Health Services Accessibility; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Immunobiological activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, and 2,6-diaminopurines.
Topics: 2-Aminopurine; Adenine; Adjuvants, Immunologic; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Female; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Role of baseline human immunodeficiency virus genotype as a predictor of viral response to tenofovir in heavily pretreated patients.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Female; HIV; HIV Infections; Humans; Male; Organophosphonates; Organophosphorus Compounds; RNA, Viral; Tenofovir | 2003 |
Use of adefovir in the treatment of the chronic hepatitis B virus infection with resistance to lamivudine.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Patient Selection; Recurrence; Treatment Failure; Viremia | 2003 |
Fanconi-like syndrome and rhabdomyolysis in a person with HIV infection on highly active antiretroviral treatment including tenofovir.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Fanconi Syndrome; Female; HIV Seropositivity; Humans; Middle Aged; Organophosphonates; Organophosphorus Compounds; Rhabdomyolysis; Tenofovir | 2003 |
Summaries for patients. Treatment for resistant HIV-1 infection.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Double-Blind Method; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Male; Mutation; Organophosphonates; Organophosphorus Compounds; Placebos; RNA; Tenofovir; Viral Load | 2003 |
Recent studies of adefovir dipivoxil for hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Child; Controlled Clinical Trials as Topic; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Organophosphonates; Treatment Outcome | 2003 |
Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity.
Topics: 4-Butyrolactone; Adenine; Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Cell Nucleus; Diphosphates; Drug Design; Drug Screening Assays, Antitumor; Furans; Humans; Microtubules; Organophosphonates; Paclitaxel; Prodrugs; Ribonucleoside Diphosphate Reductase; Solubility; Structure-Activity Relationship | 2003 |
Tenofovir disoproxil fumarate.
Topics: Adenine; Anti-HIV Agents; Drug Interactions; Drug Resistance, Viral; Hepatitis B virus; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge.
Topics: Adenine; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; DNA Primers; Gene Products, env; Gene Products, gag; Intestines; Lymphoid Tissue; Macaca mulatta; Male; Organophosphonates; Organophosphorus Compounds; Retroviridae Proteins, Oncogenic; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Fusion Proteins; Viral Load; Viremia | 2003 |
Cambodia: can a drug provide some protection?
Topics: Adenine; Animals; Anti-HIV Agents; Cambodia; Controlled Clinical Trials as Topic; Female; Haplorhini; HIV Infections; Humans; International Cooperation; Male; Organophosphonates; Organophosphorus Compounds; Sex Work; Simian Acquired Immunodeficiency Syndrome; Tenofovir | 2003 |
Drug points: Fatal lactic acidosis associated with tenofovir.
Topics: Acidosis, Lactic; Adenine; Anti-HIV Agents; Fatal Outcome; Female; Humans; Middle Aged; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Mechanistic basis for reduced viral and enzymatic fitness of HIV-1 reverse transcriptase containing both K65R and M184V mutations.
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Binding Sites; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Models, Molecular; Mutagenesis, Site-Directed; Organophosphonates; Organophosphorus Compounds; Phenotype; Protein Conformation; Recombinant Proteins; Tenofovir; Zidovudine | 2004 |
[Further indications for tenofovir].
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; Viral Load | 2003 |
Cytostatic activity of antiviral acyclic nucleoside phosphonates in rodent lymphocytes.
Topics: Adenine; Animals; Antineoplastic Agents; Antiviral Agents; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Inhibitory Concentration 50; Interleukin-10; Interleukin-2; Lymphocytes; Mice; Mice, Inbred C57BL; Nucleosides; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Tenofovir | 2003 |
Tenofovir resistance and resensitization.
Topics: Adenine; Computational Biology; Drug Resistance, Viral; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Models, Biological; Mutagenesis, Site-Directed; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine | 2003 |
Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure.
Topics: Acute Disease; Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Graft Survival; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Hospital Mortality; Humans; Liver Failure; Liver Transplantation; Living Donors; Male; Middle Aged; Organophosphonates; Retrospective Studies; Survival Analysis | 2003 |
Management of chronic hepatitis B in an HIV-positive patient with 3TC-resistant hepatitis B virus.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Interferon-alpha; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Warning issued on non-response rates.
Topics: Adenine; Anti-HIV Agents; Dideoxynucleosides; Drug Combinations; HIV Infections; Humans; Lamivudine; Multicenter Studies as Topic; Organophosphonates; Organophosphorus Compounds; Randomized Controlled Trials as Topic; Tenofovir | 2003 |
Studies of molecular mechanism of tenofovir against 3TC- and AZT-resistance mutant HIV-1 reverse transcriptase.
Topics: Adenine; Amino Acid Sequence; Drug Resistance, Viral; HIV Reverse Transcriptase; Humans; Lamivudine; Models, Molecular; Mutagenesis, Site-Directed; Organophosphonates; Organophosphorus Compounds; Protein Conformation; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2003 |
Acute tubular necrosis in a patient receiving tenofovir.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Creatinine; HIV Infections; Humans; Kidney Tubular Necrosis, Acute; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2003 |
Triple combinations regimens for HIV.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Multicenter Studies as Topic; Organophosphonates; Organophosphorus Compounds; Oxazines; Randomized Controlled Trials as Topic; Tenofovir; Treatment Failure | 2003 |
Complex patterns of viral load decay under antiretroviral therapy: influence of pharmacokinetics and intracellular delay.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; HIV-1; Humans; Models, Biological; Organophosphonates; Organophosphorus Compounds; Ritonavir; Tenofovir; Time Factors; Viral Load; Virus Replication | 2004 |
Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice.
Topics: Adenine; Animals; Female; Fertility; Granuloma; Intestines; Liver; Male; Mice; Organophosphonates; Organophosphorus Compounds; Parasite Egg Count; Praziquantel; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides | 2003 |
Selection of a hepatitis B virus strain resistant to adefovir in a liver transplantation patient.
Topics: Adenine; Amino Acid Sequence; Combined Modality Therapy; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Reverse Transcriptase Inhibitors | 2003 |
Treatment of pre- and post-liver transplantation HBV infection: Should we aim at combination therapy?
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Organophosphonates | 2003 |
Inhibitory effect of adefovir and lamivudine on the initiation of hepatitis B virus infection in primary tupaia hepatocytes.
Topics: Adenine; Animals; Antiviral Agents; DNA, Circular; DNA, Viral; Drug Therapy, Combination; Hepatitis B Antibodies; Hepatitis B virus; Hepatocytes; Lamivudine; Organophosphonates; Tupaia; Virus Replication | 2003 |
Adefovir dipivoxil therapy for lamivudine-resistant hepatitis B in pre- and post-liver transplantation patients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Child; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates | 2003 |
Resistance of HBV to adefovir dipivoxil: a case for combination antiviral therapy?
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Lamivudine; Mutation; Organophosphonates | 2003 |
Meeting notes from the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment. Exploring once-daily tenofovir + 3TC + abacavir: an argument for clinical-trials-based data.
Topics: Adenine; Dideoxynucleosides; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Pilot Projects; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector.
Topics: Adenine; Antiviral Agents; Cell Line; Cloning, Molecular; DNA, Viral; Drug Resistance, Viral; Genetic Vectors; Genome, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Virus Replication | 2004 |
BMS issues PK notice regarding ATV + TDF.
Topics: Adenine; Anti-HIV Agents; Area Under Curve; Atazanavir Sulfate; Clinical Trials as Topic; Drug Industry; HIV Infections; Humans; Oligopeptides; Organophosphonates; Organophosphorus Compounds; Pyridines; Tenofovir; United States; United States Food and Drug Administration | 2003 |
Failure of combination abacavir + tenofovir + lamivudine (3TC).
Topics: Adenine; Dideoxynucleosides; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Meeting notes from the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Suboptimal response to once-daily abacavir + 3TC + tenofovir.
Topics: Adenine; Anti-HIV Agents; Dideoxynucleosides; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Multicenter Studies as Topic; Organophosphonates; Organophosphorus Compounds; Randomized Controlled Trials as Topic; Tenofovir | 2003 |
Antivirals for the treatment of chronic hepatitis B: current and future options.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Survival Analysis; Viral Load | 2003 |
Treatment of chronic hepatitis B in the human immunodeficiency virus-infected patient: present and future.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Forecasting; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2003 |
Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Diabetes Insipidus, Nephrogenic; Didanosine; Drug Therapy, Combination; Fanconi Syndrome; Humans; Lopinavir; Male; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Ritonavir; Tenofovir | 2003 |
[Adefovir].
Topics: Adenine; Antiviral Agents; Drug Monitoring; Drug Prescriptions; Hepatitis B, Chronic; Humans; Organophosphonates; Patient Education as Topic; Patient Selection | 2003 |
Tenofovir: a nucleotide analogue reverse-transcriptase inhibitor for treatment of HIV infection.
Topics: Adenine; Aged; Child; Clinical Trials as Topic; Counseling; Education, Continuing; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Safety; Tenofovir; Treatment Outcome; United States | 2004 |
[Update in the treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Evaluation; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2004 |
The renal tolerance of low-dose adefovir dipivoxil by lamivudine-resistant individuals co-infected with hepatitis B and HIV.
Topics: Adenine; Administration, Oral; Adult; Cohort Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B, Chronic; HIV Infections; Humans; Kidney; Kidney Function Tests; Lamivudine; Male; Maximum Tolerated Dose; Middle Aged; Organophosphonates; Prospective Studies; Risk Assessment; Treatment Outcome | 2004 |
Early nonresponse for tenofovir regimen.
Topics: Adenine; Anti-HIV Agents; Dideoxynucleosides; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure | 2003 |
Efficacy of combined lamivudine and adefovir dipivoxil treatment for severe HBV graft reinfection after living donor liver transplantation.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Immunization, Passive; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates | 2003 |
Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia.
Topics: Adenine; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Humans; Microglia; Multidrug Resistance-Associated Proteins; Organophosphonates; Rats; Rats, Wistar; RNA, Messenger; Tritium | 2004 |
Can AIDS drug also prevent HIV infection?
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Female; HIV Infections; HIV-1; Homosexuality, Male; Humans; Male; Organophosphonates; Organophosphorus Compounds; Primary Prevention; Sex Work; Tenofovir; Virus Replication | 2004 |
Highly uneven distribution of tenofovir-selected simian immunodeficiency virus in different anatomical sites of rhesus macaques.
Topics: Adenine; Animals; DNA Mutational Analysis; Drug Resistance, Viral; Genotype; Longitudinal Studies; Macaca mulatta; Male; Organ Specificity; Organophosphonates; Organophosphorus Compounds; Reproducibility of Results; Reverse Transcriptase Inhibitors; Simian Immunodeficiency Virus; Tenofovir; Viremia | 2004 |
Favourable outcome of adefovir-dipivoxil treatment in acute de novo hepatitis B after liver transplantation.
Topics: Acute Disease; Adenine; Antiviral Agents; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Humans; Liver Transplantation; Male; Middle Aged; Organophosphonates | 2004 |
[New antiviral agent. Hepatitis B therapy with slight resistance risk].
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors | 2003 |
Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Antigens, Bacterial; Antiviral Agents; Bacterial Toxins; Binding Sites; Cell Line; CHO Cells; Cricetinae; Cyclic AMP; Exotoxins; Hepatitis B, Chronic; Kinetics; Models, Molecular; Organophosphonates; Protein Conformation; Recombinant Proteins; Spodoptera; Transfection | 2004 |
Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations.
Topics: Adenine; Adenosine Triphosphate; Cells, Cultured; DNA Primers; DNA Transposable Elements; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Models, Molecular; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Serine; Tenofovir; Thymidine | 2004 |
Antiretroviral therapy and HIV/hepatitis B virus coinfection.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
High rate of virologic failure with once-daily ddI/3TC/TDF.
Topics: Adenine; Didanosine; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2003 |
Rearrangement process occurring in the fragmentation of adefovir derivatives.
Topics: Adenine; Antiviral Agents; Organophosphonates; Spectrometry, Mass, Electrospray Ionization | 2004 |
Severe exacerbation of chronic hepatitis B after emergence of lamivudine resistance in a cirrhotic patient: immediate switch to adefovir dipivoxil appears to be indicated.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Failure; Liver Transplantation; Living Donors; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.
Topics: Adenine; Amides; Animals; Cell Line, Tumor; DNA; Drug Screening Assays, Antitumor; Furans; Humans; Imides; Intercalating Agents; Isoquinolines; Mice; Mice, Nude; Models, Molecular; Naphthalimides; Neoplasm Transplantation; Organophosphonates; Structure-Activity Relationship; Thiophenes; Transplantation, Heterologous | 2004 |
Labeling changes for tenofovir.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Interactions; Drug Labeling; Drug Therapy, Combination; Emtricitabine; Humans; Liver Diseases; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
[Viral hepatitis B/C and HIV. Therapy of double infections].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B; Hepatitis C; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Treatment Outcome | 2003 |
[First nucleotide analog with noteworthy safety profile. Tenofovir effective in all stages of the infection].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Clinical Trials, Phase III as Topic; Humans; Multicenter Studies as Topic; Organophosphonates; Organophosphorus Compounds; Randomized Controlled Trials as Topic; Tenofovir; Treatment Outcome; Virus Replication | 2003 |
[Resistance in a new light. About mutations and their interactions].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Drug Resistance, Multiple, Viral; HIV-1; Humans; Microbial Sensitivity Tests; Mutagenesis; Organophosphonates; Organophosphorus Compounds; Tenofovir; Treatment Outcome; Virus Replication | 2003 |
[Lipid profile and body fat--significant "side effect" of antiretroviral therapy. Tenofovir: favorable profile of adverse effects].
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Body Composition; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; Humans; Lamivudine; Lipids; Organophosphonates; Organophosphorus Compounds; Oxazines; Stavudine; Tenofovir | 2003 |
Tenofovir disoproxil fumarate for the treatment of lamivudine-resistant hepatitis B.
Topics: Adenine; Administration, Oral; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Risk Assessment; Sampling Studies; Severity of Illness Index; Tenofovir; Treatment Outcome; Viral Load | 2004 |
Hepatitis B infection in an HIV-positive man treated with tenofovir: a case of re-infection or reactivation?
Topics: Adenine; Adult; Hepatitis B Antibodies; Hepatitis B virus; HIV Infections; Humans; Male; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; Virus Activation | 2004 |
Role of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovir.
Topics: Adenine; Allopurinol; Anti-HIV Agents; Antimetabolites; Antiviral Agents; Biotransformation; Caco-2 Cells; Chromatography, High Pressure Liquid; Didanosine; Drug Interactions; Enzyme Inhibitors; Ganciclovir; Humans; Intestinal Absorption; Kinetics; Organophosphonates; Organophosphorus Compounds; Permeability; Purine-Nucleoside Phosphorylase; Substrate Specificity; Tenofovir | 2004 |
Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine.
Topics: Adenine; Anti-HIV Agents; Cloning, Molecular; Dideoxynucleosides; Drug Combinations; Drug Resistance, Viral; Genotype; HIV; HIV Reverse Transcriptase; Humans; Lamivudine; Mutation; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin.
Topics: Adenine; Adult; Antiviral Agents; Cholestasis, Intrahepatic; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Core Antigens; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Organophosphonates; Promoter Regions, Genetic; Reoperation; Treatment Outcome | 2004 |
French investigators warn of LPV/TDF/ddI interaction.
Topics: Adenine; CD4 Lymphocyte Count; Didanosine; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Organophosphonates; Organophosphorus Compounds; Pyrimidinones; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2003 |
Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Nucleosides; Nucleotides; Organophosphonates; Organophosphorus Compounds; Prevalence; Tenofovir | 2004 |
Tenofovir-related nephrotoxicity in HIV-infected patients.
Topics: Acute Kidney Injury; Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Didanosine; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Oxazines; Tenofovir | 2004 |
Ultra sensitive method for the determination of 9-(2-phosphonylmethoxyethyl)adenine in human serum by liquid chromatography-tandem mass spectrometry.
Topics: Adenine; Antiviral Agents; Chromatography, Liquid; Humans; Mass Spectrometry; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity | 2004 |
The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon.
Topics: Adenine; Animals; Diphosphates; DNA; DNA-Directed DNA Polymerase; Exonucleases; Kinetics; Molecular Structure; Oligonucleotides; Organophosphonates; Organophosphorus Compounds; Proliferating Cell Nuclear Antigen; Rats; Substrate Specificity; Templates, Genetic | 2004 |
Fanconi syndrome and acute renal failure in a patient treated with tenofovir: a call for caution.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Fanconi Syndrome; HIV Seropositivity; HIV-1; Humans; Male; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
Renal tubular dysfunction associated with tenofovir therapy: report of 7 cases.
Topics: Adenine; Adult; Anti-HIV Agents; Body Weight; Drug Therapy, Combination; Female; Glycosuria; Humans; Hypophosphatemia; Kidney Tubules; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Proteinuria; Tenofovir; Treatment Outcome | 2004 |
EU issues warning about HAART regimen.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Didanosine; Dideoxynucleosides; Drug Resistance, Viral; European Union; HIV Infections; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Patient Selection; Pilot Projects; Safety; Tenofovir; Treatment Failure; Viral Load | 2004 |
Unexpected CD4 cell count decline in patients receiving didanosine and tenofovir-based regimens despite undetectable viral load.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Didanosine; Drug Interactions; Drug Therapy, Combination; Follow-Up Studies; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2004 |
Didanosine-associated toxicity: a predictable complication of therapy with tenofovir and didanosine?
Topics: Adenine; Adult; Anti-HIV Agents; Creatinine; Didanosine; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Tenofovir | 2004 |
Design, synthesis, and characterization of a series of cytochrome P(450) 3A-activated prodrugs (HepDirect prodrugs) useful for targeting phosph(on)ate-based drugs to the liver.
Topics: Adenine; Animals; Catalysis; Cytarabine; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Drug Design; Hepatocytes; Humans; Liver; Male; Organophosphonates; Phosphates; Phosphotransferases; Prodrugs; Rats; Stereoisomerism; Time Factors; Vidarabine | 2004 |
Adefovir dipivoxil as a treatment for hepatic failure caused by lamivudine-resistant HBV strains.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Failure; Male; Middle Aged; Organophosphonates; Retreatment; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaques.
Topics: Absorptiometry, Photon; Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Area Under Curve; Blood Chemical Analysis; Bone and Bones; Bone Density; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Glycosuria; Half-Life; Macaca mulatta; Male; Organophosphonates; Organophosphorus Compounds; Phosphorus; Tenofovir; Time Factors; Weight Gain | 2004 |
Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.
Topics: Adenine; Base Sequence; DNA Primers; DNA, Viral; HIV Reverse Transcriptase; Models, Molecular; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
CD8+-cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment.
Topics: Adenine; Animals; Antiviral Agents; CD8-Positive T-Lymphocytes; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viremia; Virus Replication | 2004 |
[Adefovir dipivoxil--a further step in the control of chronic viral hepatitis B. There is still a long way to go].
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2004 |
Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents.
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B virus; Lamivudine; Mutation; Nucleic Acid Synthesis Inhibitors; Oligodeoxyribonucleotides; Organophosphonates; Organothiophosphorus Compounds; Reverse Transcriptase Inhibitors; Viral Proteins; Virus Replication | 2004 |
[A case of liver cirrhosis B resistant to lamivudine showing the clinical effect of adefovir dipivoxil].
Topics: Adenine; Amino Acid Motifs; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2004 |
In vitro selection of drug-resistant varicella-zoster virus (VZV) mutants (OKA strain): differences between acyclovir and penciclovir?
Topics: 2-Aminopurine; Acyclovir; Adenine; Antiviral Agents; Arabinofuranosyluracil; Bromodeoxyuridine; Cidofovir; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Foscarnet; Guanine; Herpesvirus 3, Human; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Phenotype; Selection, Genetic; Thymidine Kinase; Viral Proteins | 2004 |
Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy.
Topics: Adenine; Antiviral Agents; Biopsy; DNA, Circular; DNA, Viral; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunohistochemistry; Organophosphonates; Polymerase Chain Reaction | 2004 |
Practical management of chronic hepatitis B infection.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Organophosphonates; Patient Selection; Treatment Outcome | 2004 |
Improvement of dyslipidemia in patients switching from stavudine to tenofovir: preliminary results.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Hyperlipidemias; Male; Organophosphonates; Organophosphorus Compounds; Prospective Studies; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir | 2004 |
Atazanavir (Reyataz): new recommendations if combined with tenofovir (Viread) -- and warning on Viagra, Cialis, and Levitra.
Topics: Adenine; Atazanavir Sulfate; Carbolines; Drug Information Services; Drug Interactions; Drug Therapy, Combination; HIV Infections; Humans; Imidazoles; Oligopeptides; Organophosphonates; Organophosphorus Compounds; Piperazines; Purines; Pyridines; Reverse Transcriptase Inhibitors; Sildenafil Citrate; Sulfones; Tadalafil; Tenofovir; Triazines; Vardenafil Dihydrochloride | 2004 |
Virologic outcome after switching from a nucleoside reverse transcriptase inhibitor to tenofovir in patients with undetectable HIV-1 RNA plasma level.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Outcome; Viremia | 2004 |
The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters.
Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antibodies, Viral; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chronic Disease; Drug Evaluation, Preclinical; Female; Injections, Subcutaneous; Lymphocyte Count; Macaca mulatta; Male; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Survival Analysis; Tenofovir; Viral Load | 2004 |
Haemolytic anaemia after nucleotide antiretroviral treatment discontinuation in a chronic hepatitis B-virus co-infected AIDS patient.
Topics: Adenine; Adult; Anemia, Hemolytic; Antiretroviral Therapy, Highly Active; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Tenofovir | 2004 |
The K65R mutation in HIV-1 reverse transcriptase.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Organophosphonates; Point Mutation; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
In vitro susceptibility of lamivudine-resistant hepatitis B virus to adefovir and tenofovir.
Topics: Adenine; Adult; Antiviral Agents; Cell Line; DNA-Directed DNA Polymerase; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Transfection; Virus Replication | 2004 |
Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Gene Products, pol; Models, Molecular; Organophosphonates | 2004 |
Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance.
Topics: Adenine; Algorithms; Anti-HIV Agents; Databases, Genetic; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV; HIV Infections; Humans; Mutation; Organophosphonates; Organophosphorus Compounds; Phenotype; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Thymidine; Zalcitabine; Zidovudine | 2004 |
Proximal tubular kidney damage and tenofovir: a role for mitochondrial toxicity?
Topics: Adenine; Adult; Anti-HIV Agents; DNA, Mitochondrial; HIV Infections; HIV-1; Humans; Kidney Diseases; Kidney Tubules, Proximal; Male; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
A novel pattern (sW195a) in surface gene of HBV DNA due to YSDD (L180M plus M204S) mutation selected during lamivudine therapy and successful treatment with adefovir dipivoxil.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Mutation, Missense; Organophosphonates | 2004 |
Statistical method for evaluation of dissolution stability in the formulation development of solid dosage forms: tablets of amonafide.
Topics: Adenine; Algorithms; Antineoplastic Agents; Chemistry, Pharmaceutical; Imides; Isoquinolines; Models, Statistical; Naphthalimides; Organophosphonates; Solubility; Spectrophotometry, Ultraviolet; Tablets | 2004 |
Suppression of lamivudine-resistant B-domain mutants by adefovir dipivoxil in the woodchuck hepatitis virus model.
Topics: Adenine; Administration, Oral; Amino Acid Motifs; Amino Acid Substitution; Animals; Antiviral Agents; Disease Models, Animal; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Virus, Woodchuck; Lamivudine; Marmota; Mutation, Missense; Organophosphonates; Protein Structure, Tertiary; Viremia; Virus Replication | 2004 |
Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion.
Topics: Adenine; Animals; Antigens, Bacterial; Cells, Cultured; Immunologic Factors; Interleukin-12; Leukocytes, Mononuclear; Lipopolysaccharides; Macaca mulatta; Organophosphonates; Staphylococcus aureus; Tenofovir | 2004 |
Tubulopathy consecutive to tenofovir-containing antiretroviral therapy in two patients infected with human immunodeficiency virus-1.
Topics: Adenine; Anti-HIV Agents; Drug Therapy, Combination; Fanconi Syndrome; HIV Infections; HIV-1; Humans; Hypophosphatemia; Kidney Tubules; Organophosphonates; Organophosphorus Compounds; Polyuria; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Adefovir dipivoxil to prevent exacerbation of lamivudine-resistant hepatitis B infection during chemotherapy for non-Hodgkin's lymphoma.
Topics: Adenine; Adult; Antiviral Agents; Carrier State; Drug Resistance; Female; Hepatitis B; Humans; Lamivudine; Lymphoma, Non-Hodgkin; Organophosphonates; Reverse Transcriptase Inhibitors | 2004 |
Tenofovir-associated nephrotoxicity: Fanconi syndrome and renal failure.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Fanconi Syndrome; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Renal Insufficiency; Tenofovir | 2004 |
Prevention of hepatitis B virus reinfection after orthotopic liver transplantation.
Topics: Adenine; Adult; Combined Modality Therapy; Female; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Postoperative Complications; Reverse Transcriptase Inhibitors; Secondary Prevention | 2004 |
Lichenoid drug eruption to tenofovir in an HIV/hepatitis B virus co-infected patient.
Topics: Adenine; Anti-HIV Agents; Drug Eruptions; Hepatitis B, Chronic; HIV Infections; Humans; Lichenoid Eruptions; Male; Middle Aged; Organophosphonates; Tenofovir | 2004 |
Nephrolithiasis and hydronephrosis in an HIV-infected man receiving tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Hydronephrosis; Kidney Calculi; Male; Organophosphonates; Tenofovir | 2004 |
AIDS research. Cambodian leader throws novel prevention trial into limbo.
Topics: Adenine; Anti-HIV Agents; Cambodia; Controlled Clinical Trials as Topic; Female; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Sex Work; Tenofovir | 2004 |
Fatal lactic acidosis associated with coadministration of didanosine and tenofovir disoproxil fumarate.
Topics: Acidosis, Lactic; Adenine; Anti-HIV Agents; Area Under Curve; Comorbidity; Didanosine; Drug Interactions; Fatal Outcome; Female; HIV Infections; Humans; Lactates; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Tenofovir | 2004 |
Liver-targeted drug delivery using HepDirect prodrugs.
Topics: Acetaminophen; Adenine; Analgesics, Non-Narcotic; Animals; Biotransformation; Bone Marrow; Cell Separation; Cytarabine; Drug Delivery Systems; Glutathione; Hepatocytes; In Vitro Techniques; Inactivation, Metabolic; Liver; Male; Mice; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Tissue Distribution | 2005 |
Acute onset of pancreatitis with concomitant use of tenofovir and didanosine.
Topics: Acute Disease; Adenine; Anti-HIV Agents; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Pancreatitis; Tenofovir | 2004 |
Correlation between rules-based interpretation and virtual phenotype interpretation of HIV-1 genotypes for predicting drug resistance in HIV-infected individuals.
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Didanosine; Dideoxynucleosides; Drug Resistance, Viral; Genotype; HIV Infections; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Nucleosides; Organophosphonates; Phenotype; Protease Inhibitors; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Penetration of enfuvirtide, tenofovir, efavirenz, and protease inhibitors in the genital tract of HIV-1-infected men.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Blood-Testis Barrier; Cyclopropanes; Enfuvirtide; Genitalia, Male; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Oxazines; Peptide Fragments; Tenofovir | 2004 |
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state.
Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beryllium; Biological Transport; Catalysis; Cations; Cell Line; Cell Membrane; Chelating Agents; Cobalt; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Edetic Acid; Fluorides; Humans; Hydrolysis; Insecta; Kinetics; Magnesium; Manganese; Methotrexate; Models, Biological; Multidrug Resistance-Associated Proteins; Nucleotides; Organophosphonates; Protein Binding; Substrate Specificity; Vanadates; Zidovudine | 2004 |
[3 years' data of tenofovir. Confirmed as a valuable building block].
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Administration Schedule; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; Humans; Lamivudine; Organophosphonates; Oxazines; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
[5 years' data are convincing. Lopinavir as primary therapy is effective and safe in the long term].
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Clinical Trials as Topic; Cyclopropanes; Drug Synergism; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Long-Term Care; Lopinavir; Organophosphonates; Oxazines; Pyrimidinones; Ritonavir; Tenofovir; Viral Load | 2004 |
Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells.
Topics: Adenine; Amino Acid Sequence; Animals; Cattle; CD4-Positive T-Lymphocytes; Disease Models, Animal; Drug Therapy, Combination; HIV Protease Inhibitors; Indinavir; Lung; Lymphocyte Count; Macaca mulatta; Macaca nemestrina; Molecular Sequence Data; Mycobacterium bovis; Organophosphonates; Receptors, Antigen, T-Cell, gamma-delta; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Tuberculosis, Bovine | 2004 |
Prevention trials starting.
Topics: Adenine; Adult; Africa; Clinical Trials as Topic; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; United States | 2004 |
Cambodia stops important tenofovir prevention trial.
Topics: Adenine; Cambodia; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Combinations of adefovir with nucleoside analogs produce additive antiviral effects against hepatitis B virus in vitro.
Topics: Adenine; Antiviral Agents; Blotting, Southern; Cell Line; Cell Survival; Drug Combinations; Drug Synergism; Hepatitis B virus; Humans; Nucleosides; Organophosphonates | 2004 |
Effective metabolism and long intracellular half life of the anti-hepatitis B agent adefovir in hepatic cells.
Topics: Adenine; Animals; Antiviral Agents; Biological Transport; Cells, Cultured; Deoxyadenine Nucleotides; Half-Life; Hepatitis B virus; Hepatocytes; Humans; Organophosphonates; Phosphorylation | 2004 |
Trial of antiretroviral for HIV prevention on hold.
Topics: Adenine; Anti-HIV Agents; Cambodia; Controlled Clinical Trials as Topic; Double-Blind Method; Ethics Committees, Research; Ethics, Research; Female; HIV Infections; Humans; Insurance, Health; International Cooperation; National Institutes of Health (U.S.); Organophosphonates; Organophosphorus Compounds; Research Design; Sex Work; Tenofovir; United States; Women, Working | 2004 |
Intracellular pharmacology of emtricitabine and tenofovir.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Half-Life; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Outcomes in liver transplant recipients with hepatitis B virus: resistance and recurrence patterns from a large transplant center over the last decade.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Graft Survival; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Failure; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence; Retrospective Studies; Survival Analysis; Treatment Outcome | 2004 |
[Active prevention and treatment of superinfection with HBV, HCV and HIV].
Topics: Adenine; Antiretroviral Therapy, Highly Active; Hepatitis B, Chronic; Hepatitis C, Chronic; HIV Infections; Humans; Lamivudine; Organophosphonates | 2004 |
Quantification of isomeric equilibria formed by metal ion complexes of 8-[2-(phosphonomethoxy)ethyl]-8-azaadenine (8,8aPMEA) and 9-[2-(phosphonomethoxy)ethyl]-8-azaadenine (9,8aPMEA). Derivatives of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy
Topics: Adenine; Antiviral Agents; Aza Compounds; Calcium; Cations, Divalent; Chelating Agents; Copper; Drug Stability; Ethers; Hydrogen-Ion Concentration; Isomerism; Kinetics; Ligands; Metals; Nucleotides; Organometallic Compounds; Organophosphonates; Potentiometry; Zinc | 2004 |
[An attempt to approach an optional therapeutic regimen for chronic hepatitis B].
Topics: Adenine; Animals; Antiviral Agents; Combined Modality Therapy; Genetic Therapy; Hepatitis B Antigens; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Recombinant Proteins | 2004 |
Tenofovir therapy for lamivudine resistance following liver transplantation.
Topics: Adenine; Adult; Antiviral Agents; Chronic Disease; Drug Resistance, Viral; Hepatitis B; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Organophosphonates; Retrospective Studies; Salvage Therapy; Tenofovir; Treatment Outcome | 2004 |
Tenofovir, equivalence, and noninferiority.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; Viral Load | 2004 |
Increasing prevalence of HIV-1 reverse transcriptase mutation K65R correlates with tenofovir utilization.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Organophosphonates; Prevalence; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Tenofovir use in a patient with a severe renal impairment.
Topics: Adenine; Adult; Diabetic Nephropathies; Dideoxynucleosides; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2004 |
Adefovir dipivoxil as the rescue therapy for lamivudine-resistant hepatitis B post liver transplant.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Child; Drug Resistance; Follow-Up Studies; Hepatitis B; Humans; Lamivudine; Liver Transplantation; Middle Aged; Organophosphonates; Postoperative Complications; Recurrence; Retrospective Studies | 2004 |
Adefovir dipivoxil for treatment of breakthrough hepatitis caused by lamivudine-resistant mutants of hepatitis B virus.
Topics: Adenine; Adult; Alanine Transaminase; Drug Resistance, Microbial; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Safety; Treatment Outcome | 2004 |
6-[2-phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines: a new class of acyclic pyrimidine nucleoside phosphonates with antiviral activity.
Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antiviral Agents; Hepadnaviridae; Herpesviridae; Mice; Models, Chemical; Moloney murine sarcoma virus; Nucleosides; Organophosphonates; Poxviridae; Pyrimidine Nucleosides; Pyrimidines; Reverse Transcriptase Inhibitors; Tenofovir | 2004 |
Successful therapy of hepatitis B with tenofovir in HIV-infected patients failing previous adefovir and lamivudine treatment.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Chronic Disease; DNA-Directed DNA Polymerase; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2004 |
Predictors of selection of K65R: tenofovir use and lack of thymidine analogue mutations.
Topics: Adenine; Anti-HIV Agents; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine | 2004 |
The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro.
Topics: 3T3-L1 Cells; Adenine; Adipocytes; Animals; Apoptosis; Cell Differentiation; Didanosine; Dideoxynucleosides; HIV-1; HIV-Associated Lipodystrophy Syndrome; Lamivudine; Lipid Metabolism; Mice; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Zidovudine | 2004 |
Impact of a treatment including tenofovir plus didanosine on the selection of the 65R mutation in highly drug-experienced HIV-infected patients.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Databases, Genetic; Didanosine; DNA, Viral; Drug Resistance, Multiple, Viral; Gene Deletion; Genotype; HIV Infections; HIV-1; Humans; Mutation; Organophosphonates; Tenofovir | 2004 |
Renal dysfunction with tenofovir disoproxil fumarate-containing highly active antiretroviral therapy regimens is not observed more frequently: a cohort and case-control study.
Topics: Adenine; Albuminuria; Antiretroviral Therapy, Highly Active; Case-Control Studies; Cohort Studies; Creatinine; Follow-Up Studies; HIV Infections; Humans; Organophosphonates; Proteinuria; Renal Insufficiency; Tenofovir | 2004 |
Pharmacokinetics of saquinavir hard gel/ritonavir (1000/100 mg twice daily) when administered with tenofovir diproxil fumarate in HIV-1-infected subjects.
Topics: Adenine; Adult; Anti-HIV Agents; Area Under Curve; Drug Combinations; Drug Interactions; Gels; Half-Life; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Middle Aged; Organophosphonates; Ritonavir; Saquinavir; Tenofovir | 2005 |
Prevalence and conditions of selection of the K65R mutation in the reverse transcriptase gene of HIV-1.
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Drug Resistance, Viral; Gene Frequency; Genes, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Organophosphonates; Point Mutation; Reverse Transcriptase Inhibitors; Selection, Genetic; Tenofovir | 2005 |
Warning on two specific 3-drug regimens: Viread + Didanosine + either Sustiva or Viramune.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Nevirapine; Organophosphonates; Oxazines; Tenofovir; United States; United States Food and Drug Administration | 2004 |
Adefovir treatment in posttransplant hepatitis B virus infection resistant to lamivudine plus hepatitis B virus immunoglobulin.
Topics: Adenine; Adult; Antibodies, Viral; Antiviral Agents; Drug Resistance; Female; Hepatitis B; Hepatitis B Antibodies; Humans; Lamivudine; Living Donors; Male; Middle Aged; Organophosphonates; Recurrence | 2004 |
CD4 cell decline with didanosine and tenofovir and failure of triple nucleoside/nucleotide regimens may be related.
Topics: Adenine; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Didanosine; Drug Interactions; Drug Therapy, Combination; HIV Infections; Humans; Lymphopenia; Organophosphonates; Purine-Nucleoside Phosphorylase; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure | 2004 |
Antiretroviral therapy with tenofovir is associated with mild renal dysfunction.
Topics: Adenine; Anti-HIV Agents; Creatinine; Cross-Sectional Studies; Cystatin C; Cystatins; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Organophosphonates; Proteinuria; Tenofovir | 2005 |
Low rate of treatment failure on antiretroviral therapy with tenofovir, lamivudine and zidovudine.
Topics: Adenine; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Failure; Zidovudine | 2005 |
Chronic infection with hepatitis B viruses and antiviral drug evaluation in uPA mice after liver repopulation with tupaia hepatocytes.
Topics: Adenine; Animals; Antiviral Agents; Disease Models, Animal; DNA, Circular; DNA, Viral; Hepatitis B, Chronic; Hepatocytes; Mice; Organophosphonates; Transplantation, Heterologous; Tupaia; Urokinase-Type Plasminogen Activator | 2005 |
Box warning updated for tenofovir.
Topics: Adenine; Animals; Carcinogens; Drug Labeling; Female; Humans; Male; Mice; Organophosphonates; Tenofovir | 2004 |
Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.
Topics: Adenine; Adenoviruses, Human; Antiviral Agents; Cells, Cultured; Cidofovir; Cytosine; Esters; Ether; Humans; Lipids; Microbial Sensitivity Tests; Nucleosides; Organophosphonates; Prodrugs; Virus Replication | 2005 |
Tenofovir and renal toxicity.
Topics: Adenine; Anti-HIV Agents; Creatinine; Humans; Kidney Diseases; Organophosphonates; Tenofovir; Viral Load | 2004 |
Remofovir mesylate: a prodrug of PMEA with improved liver-targeting and safety in rats and monkeys.
Topics: Adenine; Animals; Antiviral Agents; Autoradiography; Carbon Radioisotopes; Dose-Response Relationship, Drug; Drug Delivery Systems; Haplorhini; Hepatitis B, Chronic; Kidney; Liver; Mesylates; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Species Specificity; Tissue Distribution | 2004 |
Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Drug Resistance, Viral; Female; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Prothrombin Time; Serum Albumin; Viral Load | 2005 |
Adefovir dipivoxil for chemotherapy-induced activation of hepatitis B virus infection.
Topics: Acute Disease; Adenine; Aged; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Hepatitis B; Hepatitis B virus; Humans; Male; Organophosphonates; Prostatic Neoplasms; Virus Activation | 2005 |
Sustained HBs seroconversion during lamivudine and adefovir dipivoxil combination therapy for lamivudine failure.
Topics: Adenine; Adult; DNA, Viral; Drug Therapy, Combination; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Polymerase Chain Reaction; Treatment Failure | 2005 |
The experts speak. Studying the potential of tenofovir to prevent sexual transmission of HIV: first steps. Interview by Vicki Glaser.
Topics: Adenine; Communicable Disease Control; Female; HIV Infections; Humans; Male; Organophosphonates; Primary Prevention; Risk Assessment; Sensitivity and Specificity; Sexually Transmitted Diseases; Tenofovir; Treatment Outcome | 2005 |
Early virological failure in treatment-naive HIV-infected adults receiving didanosine and tenofovir plus efavirenz or nevirapine.
Topics: Adenine; Adult; Aged; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Didanosine; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nevirapine; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir | 2005 |
Tenofovir-induced acute renal failure in an HIV patient with normal renal function.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Male; Organophosphonates; Renal Dialysis; Tenofovir | 2005 |
Tenofovir: a pill to prevent HIV?
Topics: Adenine; Anti-HIV Agents; Drugs, Investigational; HIV Infections; Humans; Organophosphonates; Tenofovir | 2005 |
Early antiretroviral therapy for simian immunodeficiency virus infection leads to mucosal CD4+ T-cell restoration and enhanced gene expression regulating mucosal repair and regeneration.
Topics: Adenine; Animals; Anti-Retroviral Agents; Antibody Formation; Antigen Presentation; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Gene Expression; Gene Expression Profiling; Immunity, Mucosal; Intestinal Mucosa; Lymphocyte Activation; Lymphoid Tissue; Macaca mulatta; Male; Oligonucleotide Array Sequence Analysis; Organophosphonates; Regeneration; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2005 |
[Determination of adefovir dipivoxil and its degradation products by reversed-phase high performance liquid chromatography].
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Indicators and Reagents; Organophosphonates | 2004 |
Meeting notes from ICAAC. Tenofovir + ddI: a combination to avoid.
Topics: Adenine; CD4 Lymphocyte Count; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2005 |
Meeting notes from ICAAC. Tenofovir + emtricitabine vs. AZT + 3TC.
Topics: Adenine; CD4 Lymphocyte Count; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load; Zidovudine | 2005 |
Selection of a rare resistance profile in an HIV-1-infected patient exhibiting a failure to an antiretroviral regimen including tenofovir DF.
Topics: Adenine; Adult; Anti-HIV Agents; Didanosine; Dideoxynucleosides; Drug Resistance, Viral; Female; Gabon; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Lopinavir; Microbial Sensitivity Tests; Mutation; Organophosphonates; Pyrimidinones; Tenofovir; Viral Load | 2005 |
Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities.
Topics: Adenine; Antiviral Agents; Hepatitis B virus; Nucleosides; Organophosphonates; Structure-Activity Relationship | 2005 |
Serum hypophosphatemia in tenofovir disoproxil fumarate recipients is multifactorial in origin, questioning the utility of its monitoring in clinical practice.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blood Chemical Analysis; Creatinine; Fanconi Syndrome; Female; HIV Infections; Humans; Hypophosphatemia; Lopinavir; Male; Organophosphonates; Phosphates; Prospective Studies; Pyrimidinones; Reproducibility of Results; Tenofovir; Urea | 2005 |
Adefovir dipivoxil added to ongoing lamivudine therapy in patients with lamivudine-resistant hepatitis B e antigen-negative chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Combinations; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2005 |
Predictors of residual viremia in HIV-infected patients successfully treated with efavirenz and lamivudine plus either tenofovir or stavudine.
Topics: Adenine; Adolescent; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; DNA, Viral; Female; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Oxazines; RNA, Viral; Stavudine; Tenofovir; Viremia | 2005 |
Women testing tenofovir for HIV prevention.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Female; HIV Infections; Humans; Nigeria; Organophosphonates; Sex Work; Tenofovir | 2005 |
Collaboration begins on combined drug.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; Humans; Organophosphonates; Oxazines; Tenofovir | 2005 |
AIDS clinical trials. More woes for novel HIV prevention approach.
Topics: Adenine; Anti-HIV Agents; Centers for Disease Control and Prevention, U.S.; Clinical Trials as Topic; HIV Infections; Humans; Nigeria; Organophosphonates; Patient Selection; Sex Work; Substance Abuse, Intravenous; Tenofovir; Thailand; United States | 2005 |
[Therapeutic effect of adefovir dipivoxil on recurrent or de novo infection of hepatitis B virus after liver transplantation: a preliminary report].
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2005 |
Early virologic failure in a pilot study evaluating the efficacy of therapy containing once-daily abacavir, lamivudine, and tenofovir DF in treatment-naive HIV-infected patients.
Topics: Adenine; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Pilot Projects; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure; Viral Load | 2005 |
[Advances in treatment of chronic hepatitis B].
Topics: Adenine; Animals; Antiviral Agents; Drug Therapy, Combination; Genetic Therapy; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Phytotherapy | 2005 |
Prophylaxis of hepatitis B virus recurrence after liver transplantation in carriers of lamivudine-resistant mutants.
Topics: Adenine; Adult; Antibodies, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Organophosphonates; Phenotype; Retrospective Studies; Reverse Transcriptase Inhibitors; Secondary Prevention | 2005 |
Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue.
Topics: Adenine; Alanine; Animals; Anti-HIV Agents; Area Under Curve; CD4-Positive T-Lymphocytes; Chromatography, High Pressure Liquid; Dogs; HIV-1; Humans; In Vitro Techniques; Lymphatic System; Male; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Spectrophotometry, Ultraviolet; Tenofovir; Tissue Distribution | 2005 |
Pharmacokinetics of tenofovir in breast milk of lactating rhesus macaques.
Topics: Adenine; Animals; Anti-HIV Agents; Area Under Curve; Female; Half-Life; Macaca mulatta; Milk; Organophosphonates; Pilot Projects; Tenofovir | 2005 |
SIV-specific T lymphocyte responses in PBMC and lymphoid tissues of SIV-infected pigtailed macaques during suppressive combination antiretroviral therapy.
Topics: Adenine; Animals; Anti-Retroviral Agents; Drug Therapy, Combination; Emtricitabine; Immunity, Cellular; Interferon-gamma; Linear Models; Macaca nemestrina; Organophosphonates; Primate Diseases; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir; Viremia; Zalcitabine | 2005 |
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
Topics: Adenine; Adult; Animals; Anions; Antineoplastic Agents; DNA, Complementary; Genetic Variation; Genotype; Haplotypes; Heterozygote; Humans; Kidney; Kinetics; Male; Methotrexate; Models, Chemical; Models, Genetic; Mycotoxins; Ochratoxins; Organic Anion Transport Protein 1; Organic Anion Transporters; Organophosphonates; p-Aminohippuric Acid; Pedigree; Pharmacogenetics; Polymorphism, Genetic; Protein Structure, Secondary; RNA, Complementary; Xenobiotics; Xenopus laevis | 2005 |
In vitro combination studies of tenofovir and other nucleoside analogues with ribavirin against HIV-1.
Topics: Adenine; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; Didanosine; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Synergism; HIV-1; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Ribavirin; Tenofovir | 2005 |
Treatment with adefovir dipivoxil in a renal transplant patient with renal insufficiency and lamivudine-resistant hepatitis B infection.
Topics: Adenine; Antiviral Agents; Creatinine; Drug Resistance, Viral; Follow-Up Studies; Hepatitis B; Humans; Kidney Failure, Chronic; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2005 |
Adefovir dipivoxil therapy in liver transplant recipients with lamivudine-resistant hepatitis B virus.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Immunosuppression Therapy; Lamivudine; Liver Transplantation; Middle Aged; Organophosphonates; Retrospective Studies; Viral Load | 2005 |
Switching from protease inhibitors to a single-class regimen of abacavir/lamivudine/zidovudine plus tenofovir in patients with HIV load suppression.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Female; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load; Zidovudine | 2005 |
The durability of virological success of tenofovir and didanosine dosed at either 400 or 250 mg once daily.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Didanosine; Drug Administration Schedule; HIV Infections; HIV-1; Humans; Organophosphonates; Retrospective Studies; Survival Rate; Tenofovir; Treatment Failure; Viral Load | 2005 |
The use of a triple nucleoside-nucleotide regimen for nonoccupational HIV post-exposure prophylaxis.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Chi-Square Distribution; HIV Infections; Humans; Lamivudine; Male; Nelfinavir; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Assessment; Risk-Taking; Stavudine; Tenofovir; Zidovudine | 2005 |
Summaries for patients. Antiviral regimens for chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Decision Support Techniques; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver; Markov Chains; Organophosphonates; Recombinant Proteins; Salvage Therapy; Sensitivity and Specificity; Transaminases | 2005 |
Treatment alternatives for chronic hepatitis B virus infection: a cost-effectiveness analysis.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Decision Support Techniques; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver; Markov Chains; Organophosphonates; Recombinant Proteins; Salvage Therapy; Sensitivity and Specificity; Transaminases | 2005 |
Assessing the benefits and costs of new therapies for hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Hepatitis B, Chronic; Humans; Organophosphonates | 2005 |
Resistance mutations before and after tenofovir regimen failure in HIV-1 infected patients.
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Drug Resistance, Viral; France; HIV Infections; HIV-1; Humans; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure | 2005 |
Adherence to trizivir and tenofovir as a simplified salvage regimen is associated with suppression of viraemia and a decreased cholesterol.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cholesterol; Dideoxynucleosides; Drug Combinations; Erythrocyte Indices; Humans; Lamivudine; Organophosphonates; Patient Compliance; Salvage Therapy; Tenofovir; Viral Load; Viremia; Zidovudine | 2005 |
Functional consequences of single nucleotide polymorphisms in the human organic anion transporter hOAT1 (SLC22A6).
Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Cidofovir; Cytosine; DNA; Genetic Variation; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Organic Anion Transport Protein 1; Organophosphonates; p-Aminohippuric Acid; Polymorphism, Single Nucleotide; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Complementary; Tenofovir; Xenopus laevis | 2005 |
Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir.
Topics: Adenine; Antiviral Agents; Cell Line; Drug Resistance, Viral; Genome, Viral; Hepatitis B virus; Humans; Lamivudine; Mutation; Nucleosides; Nucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; Technology, Pharmaceutical; Virus Replication | 2005 |
Fatal lactic acidosis associated with tenofovir and abacavir.
Topics: Acidosis, Lactic; Adenine; Anti-HIV Agents; Dideoxynucleosides; Fatal Outcome; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2005 |
Lack of a metabolic and antiviral drug interaction between tenofovir, abacavir and lamivudine.
Topics: Adenine; Anti-HIV Agents; Cell Line; Dideoxynucleosides; Drug Interactions; HIV-1; Humans; Lamivudine; Leukocytes, Mononuclear; Organophosphonates; Tenofovir | 2005 |
Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: effects of intercalation, side chains, and substituent groups.
Topics: Adenine; Animals; Antineoplastic Agents; Cattle; Cell Line, Tumor; DNA; DNA, Superhelical; Drug Screening Assays, Antitumor; Humans; Imides; Intercalating Agents; Isoquinolines; Leukemia P388; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mice; Models, Molecular; Naphthalenes; Naphthalimides; Organophosphonates; Phthalimides; Structure-Activity Relationship; Thiadiazines; Ultraviolet Rays | 2005 |
[Acute renal failure, Fanconi syndrome and insipidus diabetes in a HIV-infected patient treated with Tenofovir].
Topics: Acute Kidney Injury; Adenine; Adult; Diabetes Insipidus; Fanconi Syndrome; HIV Infections; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2005 |
Tenofovir helpful for patients with HBV.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Hepatitis B; HIV Infections; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir | 2005 |
Successful treatment with tenofovir in a child C cirrhotic patient with lamivudine-resistant hepatitis B virus awaiting liver transplantation. Post-transplant results.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Waiting Lists | 2005 |
Influence of inter- and intramolecular hydrogen bonding on kemp decarboxylations from QM/MM simulations.
Topics: Adenine; Carboxylic Acids; Computer Simulation; Hydrogen Bonding; Imides; Isoquinolines; Models, Molecular; Monte Carlo Method; Naphthalimides; Organophosphonates; Quantum Theory; Solvents; Thermodynamics | 2005 |
Risk factors for CD4 lymphopenia in patients treated with a tenofovir/didanosine high dose-containing highly active antiretroviral therapy regimen.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Didanosine; Female; HIV Infections; Humans; Lymphopenia; Male; Organophosphonates; Risk Factors; Tenofovir | 2005 |
Outcome of hepatitis B e antigen-negative chronic hepatitis B on long-term nucleos(t)ide analog therapy starting with lamivudine.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Liver Failure; Liver Neoplasms; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Retrospective Studies; Survival Analysis; Treatment Outcome | 2005 |
Reactivation of viral replication after replacement of tenofovir by adefovir.
Topics: Adenine; Adult; Antiviral Agents; Hepatitis B; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure; Treatment Outcome; Virus Activation | 2005 |
Viral kinetics in patients with lamivudine-resistant hepatitis B during adefovir-lamivudine combination therapy.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Models, Theoretical; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome; Virus Replication | 2005 |
The risk of adefovir monotherapy in human immunodeficiency virus (HIV) and hepatitis B virus (HBV) co-infected patients.
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Organophosphonates; Treatment Outcome | 2005 |
Antiviral effect of oral administration of tenofovir disoproxil fumarate in woodchucks with chronic woodchuck hepatitis virus infection.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Dose-Response Relationship, Drug; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Humans; Marmota; Organophosphonates; Tenofovir; Treatment Outcome; Viremia; Virus Replication | 2005 |
[Efficacy and safety of adefovir dipivoxil in patients with decompensated liver cirrhosis with Lamivudine resistance compared to patients with compensated liver disease].
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates | 2005 |
The maze of treatments for hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2005 |
Severe efavirenz-induced hypersensitivity syndrome (not-DRESS) with acute renal failure.
Topics: Acute Kidney Injury; Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Hypersensitivity; Ghana; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Male; Mycobacterium tuberculosis; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Tuberculosis | 2006 |
Acid-base and metal-ion-binding properties of 9-[2-(2-phosphonoethoxy)ethyl]adenine (PEEA), a relative of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA). An exercise on the quantification of isomeric complex equilibria in so
Topics: Adenine; Antiviral Agents; Binding Sites; Cations; Chelating Agents; Hydrogen-Ion Concentration; Isomerism; Kinetics; Ligands; Metals; Organometallic Compounds; Organophosphonates; Protons | 2005 |
Simultaneous quantification of emtricitabine and tenofovir in human plasma using high-performance liquid chromatography after solid phase extraction.
Topics: Adenine; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Emtricitabine; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Tenofovir | 2005 |
We must not let protestors derail trials of pre-exposure prophylaxis for HIV.
Topics: Adenine; Health Knowledge, Attitudes, Practice; HIV Infections; Humans; Organophosphonates; Public Opinion; Public Policy; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
The abandoned trials of pre-exposure prophylaxis for HIV: what went wrong?
Topics: Adenine; Global Health; Health Knowledge, Attitudes, Practice; HIV Infections; Humans; Organophosphonates; Patient Advocacy; Public Opinion; Randomized Controlled Trials as Topic; Research Design; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Cytidine Triphosphate; Dideoxynucleosides; Dideoxynucleotides; Drug Interactions; Female; HIV Infections; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir | 2005 |
Incidence of and risk factors for tenofovir-induced nephrotoxicity: a retrospective cohort study.
Topics: Adenine; Adult; Anti-HIV Agents; Creatinine; Female; HIV Infections; Humans; Hypophosphatemia; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Middle Aged; Organophosphonates; Proteinuria; Retrospective Studies; Risk Factors; Tenofovir; Urinalysis | 2005 |
Tenofovir and changes in renal function.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Kidney Diseases; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
[Influence of nucleoside analogues resistance on anti-HBV treatment].
Topics: Adenine; Antiviral Agents; Dideoxynucleosides; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2005 |
Murine cytomegalovirus resistant to antivirals has genetic correlates with human cytomegalovirus.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Ganciclovir; Guanine; Humans; Mice; Models, Molecular; Molecular Sequence Data; Muromegalovirus; Mutation; Organophosphonates; Protein Kinases; Sequence Alignment; Valacyclovir; Valine; Virus Replication | 2005 |
The central nervous system is a viral reservoir in simian immunodeficiency virus--infected macaques on combined antiretroviral therapy: a model for human immunodeficiency virus patients on highly active antiretroviral therapy.
Topics: Adenine; Animals; Anti-HIV Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Disease Models, Animal; DNA, Viral; Drug Therapy, Combination; Histocompatibility Antigens Class II; Injections, Subcutaneous; Macaca nemestrina; Organophosphonates; Polymerase Chain Reaction; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Zalcitabine | 2005 |
Lack of antagonism between abacavir, lamivudine, and tenofovir against wild-type and drug-resistant HIV-1.
Topics: Adenine; Anti-HIV Agents; Cell Line, Transformed; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Tenofovir | 2005 |
Population pharmacokinetics of tenofovir in human immunodeficiency virus-infected patients taking highly active antiretroviral therapy.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Area Under Curve; Bayes Theorem; Female; HIV Infections; HIV-1; Humans; Kidney Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Progression of renal impairment under therapy with tenofovir.
Topics: Adenine; Anti-HIV Agents; Case-Control Studies; Disease Progression; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Low frequency of renal function impairment during one-year of therapy with tenofovir-containing regimens in the real-world: a case-control study.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Case-Control Studies; Creatinine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; HIV Infections; Humans; Incidence; Kidney; Kidney Diseases; Kidney Function Tests; Male; Organophosphonates; Probability; Prognosis; Reference Values; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Assessment; Severity of Illness Index; Tenofovir | 2005 |
HIV/AIDS. Prevention cocktails: combining tools to Stop HIV's spread.
Topics: Acyclovir; Adenine; Anti-HIV Agents; Antidepressive Agents, Second-Generation; Antiviral Agents; Bupropion; Circumcision, Male; Clinical Trials as Topic; Contraceptive Devices, Female; Female; Herpes Genitalis; Herpesvirus 2, Human; HIV; HIV Infections; Humans; Hygiene; Male; Organophosphonates; Sexual Behavior; Tenofovir; Viral Load | 2005 |
Chronic hepatitis B--treatment with nucleoside analogues.
Topics: Adenine; Drug Resistance; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors | 2005 |
Protests may slow down trials.
Topics: Adenine; Bisexuality; Clinical Trials as Topic; Europe; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Thailand; Time Factors; United States | 2005 |
Tenofovir-induced renal tubular dysfunction presenting with hypocalcaemia.
Topics: Adenine; Anti-HIV Agents; Bone Density Conservation Agents; Fanconi Syndrome; HIV Infections; Humans; Hydroxycholecalciferols; Hypocalcemia; Male; Middle Aged; Organophosphonates; Phosphates; Tenofovir; Treatment Outcome | 2006 |
Human multidrug resistance associated protein 4 confers resistance to camptothecins.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Drug Resistance, Neoplasm; Glutathione; Humans; Irinotecan; Methotrexate; Multidrug Resistance-Associated Proteins; Organophosphonates; Paclitaxel | 2005 |
The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Fanconi Syndrome; Female; HIV Infections; Humans; Hypophosphatemia; Male; Middle Aged; Muscular Diseases; Organophosphonates; Osteomalacia; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study.
Topics: Adenine; Administration, Oral; Adult; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Male; Metabolic Clearance Rate; Organophosphonates; Pharmacokinetics; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
Adefovir-resistant hepatitis B can be associated with viral rebound and hepatic decompensation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Disease Progression; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Liver Failure; Male; Middle Aged; Mutation; Organophosphonates; Viral Load | 2005 |
[Clinical outcomes after discontinuation of Lamivudine in chronic hepatitis B patients with Lamivudine resistant HBV mutant].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2005 |
High rate of virological failure in maintenance antiretroviral therapy with didanosine and tenofovir.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Didanosine; Drug Resistance, Multiple, Viral; HIV Infections; HIV-1; Humans; Mutation; Organophosphonates; Tenofovir; Treatment Failure | 2005 |
Protease inhibitors and non-nucleoside reverse transcriptase inhibitors have a comparable effect on the CD4 cell change after switching to tenofovir-based regimens.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Absence of new thymidine-associated mutations and evidence of an immune virologic response over a 12-month period in a cohort of antiretroviral-experienced HIV-1-infected subjects treated with tenofovir combination therapy.
Topics: Adenine; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine; Viral Load | 2005 |
Lack of pharmacokinetic drug interaction between tenofovir disoproxil fumarate and nelfinavir mesylate.
Topics: Adenine; Adult; Area Under Curve; Drug Therapy, Combination; Female; HIV Protease Inhibitors; Humans; Male; Nelfinavir; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
AIDS. Promote HIV chemoprophylaxis research, don't prevent it.
Topics: Adenine; Africa; Anti-HIV Agents; Asia; Community Participation; Controlled Clinical Trials as Topic; Counseling; Developing Countries; Drug Costs; Female; Health Services Accessibility; HIV Infections; Humans; Latin America; Male; Organophosphonates; Patient Selection; Tenofovir | 2005 |
[Adefovir dipivoxil in treatment of decompensated liver cirrhosis patients with YMDD mutation].
Topics: Adenine; Adult; Aged; Amino Acid Motifs; Antiviral Agents; DNA-Directed DNA Polymerase; Female; Hepatic Encephalopathy; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Mutation; Organophosphonates; Protein Structure, Tertiary; Recurrence; Reverse Transcription | 2005 |
The tenofovir pre-exposure prophylaxis trial in Thailand: researchers should show more openness in their engagement with the community.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Community Networks; HIV Infections; Human Rights; Humans; Needle-Exchange Programs; Organophosphonates; Patient Advocacy; Research Design; Substance-Related Disorders; Tenofovir; Thailand | 2005 |
Response to Joep M. A. Lange.
Topics: Adenine; Cambodia; Clinical Trials as Topic; Health Services Accessibility; HIV Infections; Humans; Organophosphonates; Patient Advocacy; Research Design; Sex Work; Tenofovir | 2005 |
Resistance to adefovir: a new challenge in the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2005 |
HIV Pathogenesis and Treatment - Third International AIDS Society Conference.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Chemistry, Pharmaceutical; Clinical Trials as Topic; Congresses as Topic; Darunavir; Drugs, Investigational; Enfuvirtide; HIV Envelope Protein gp41; HIV Infections; HIV-1; Humans; Nitriles; Organophosphonates; Peptide Fragments; Pyrimidines; Receptors, CCR5; Reverse Transcriptase Inhibitors; Rilpivirine; Societies, Scientific; Sulfonamides; Tenofovir; Zalcitabine | 2005 |
Dose-dependent influence of didanosine on immune recovery in HIV-infected patients treated with tenofovir.
Topics: Adenine; Adult; CD4 Lymphocyte Count; Didanosine; Dose-Response Relationship, Immunologic; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Outcome | 2005 |
Renal tubular toxicity associated with tenofovir assessed using urine-beta 2 microglobulin, percentage of tubular reabsorption of phosphate and alkaline phosphatase levels.
Topics: Absorption; Adenine; Adult; Alkaline Phosphatase; Antiretroviral Therapy, Highly Active; beta 2-Microglobulin; Creatinine; HIV Infections; HIV-1; Humans; Kidney Tubules; Middle Aged; Organophosphonates; Phosphates; Phosphorus; Reverse Transcriptase Inhibitors; Tenofovir; Uric Acid | 2005 |
Risk of selecting K65R in antiretroviral-naive HIV-infected individuals with chronic hepatitis B treated with adefovir.
Topics: Adenine; Antiviral Agents; DNA, Viral; Genes, Viral; Genotype; Hepatitis B e Antigens; Hepatitis B, Chronic; HIV Infections; Humans; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral | 2005 |
Less than the sum of its parts: failure of a tenofovir-abacavir-Lamivudine triple-nucleoside regimen.
Topics: Adenine; Anti-HIV Agents; Dideoxynucleosides; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure | 2005 |
Sensitive assay for determining plasma tenofovir concentrations by LC/MS/MS.
Topics: Adenine; Calibration; Chromatography, High Pressure Liquid; HIV Infections; Humans; Mass Spectrometry; Organophosphonates; Reference Standards; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Tenofovir | 2006 |
Impact of tenofovir-containing antiretroviral therapy on chronic hepatitis B in a cohort co-infected with human immunodeficiency virus.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Evolution, Molecular; Female; Genes, pol; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Load; Viremia; Virus Replication | 2005 |
Protective effect of the acyclic nucleoside phosphonate tenofovir toward human T-cell leukemia/lymphotropic virus type 1 infection of human peripheral blood mononuclear cells in vitro.
Topics: Adenine; Anti-HIV Agents; DNA, Viral; Human T-lymphotropic virus 1; Humans; Leukemia, T-Cell; Leukocytes, Mononuclear; Organophosphonates; Tenofovir | 2005 |
Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Pilot Projects; Polymerase Chain Reaction; Prospective Studies; RNA, Viral; Treatment Outcome | 2006 |
Stakeholder consultation to address issues related to tenofovir prophylactic research.
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Organophosphonates; Referral and Consultation; Research; Tenofovir | 2005 |
A 12-month treatment with tenofovir does not impair bone mineral accrual in HIV-infected children.
Topics: Absorptiometry, Photon; Adenine; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Density; Child; HIV Infections; Humans; Organophosphonates; Stavudine; Tenofovir | 2005 |
Hopes dashed for formulation.
Topics: Absorption; Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Chemistry, Pharmaceutical; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Organophosphonates; Oxazines; Tablets; Tenofovir; Therapeutic Equivalency | 2005 |
Cost-effectiveness in hepatitis B.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Recombinant Proteins | 2005 |
Treatment of lamivudine-resistant hepatitis B in HIV-infected persons: is adefovir dipivoxil the answer?
Topics: Adenine; AIDS-Related Opportunistic Infections; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV; HIV Antibodies; Humans; Lamivudine; Organophosphonates; Treatment Outcome | 2006 |
Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft cultures.
Topics: Adenine; Animals; Cell Line; Cell Line, Transformed; Cidofovir; Cytosine; Humans; Keratinocytes; Nucleosides; Orf virus; Organophosphonates; Organophosphorus Compounds; Sheep | 2005 |
Inhibition of the replication of DNA viruses by phosphonylmethoxyalkyl-purines and -pyrimidines.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytosine; DNA Viruses; Organophosphonates; Simplexvirus; Virus Replication | 1989 |
Heart transplantation in patients with chronic hepatitis B: clinical evolution, molecular analysis, and effect of treatment.
Topics: Adenine; Adult; Alanine Transaminase; DNA, Viral; Drug Resistance, Viral; Female; Heart Diseases; Heart Transplantation; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Lamivudine; Male; Middle Aged; Organophosphonates; Postoperative Period; Promoter Regions, Genetic; Reverse Transcriptase Inhibitors; Virus Activation | 2005 |
Adefovir added to lamivudine for hepatitis B recurrent infection in refractory B-cell chronic lymphocytic leukemia on prolonged therapy with Campath-1H.
Topics: Adenine; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antineoplastic Agents; Antiviral Agents; Drug Therapy, Combination; Hepatitis B; Humans; Lamivudine; Leukemia, Lymphocytic, Chronic, B-Cell; Organophosphonates; Recurrence; Treatment Outcome | 2006 |
Adefovir rapidly suppresses hepatitis B in HBeAg-negative patients developing genotypic resistance to lamivudine.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies | 2005 |
Improved lipid profiles and maintenance of virologic control in heavily pretreated HIV-infected patients who switched from stavudine to tenofovir treatment.
Topics: Adenine; Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Lipid Metabolism; Male; Middle Aged; Organophosphonates; Retrospective Studies; Stavudine; Tenofovir | 2006 |
cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach.
Topics: Acetylcholinesterase; Adenine; Anti-HIV Agents; Benzyl Alcohols; Butyrylcholinesterase; Cell Line; Cholinesterase Inhibitors; HIV-1; HIV-2; Humans; Hydrolysis; Magnetic Resonance Spectroscopy; Organophosphonates; Prodrugs; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship | 2005 |
Virologic response and resistance to adefovir in patients with chronic hepatitis B.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Retrospective Studies; Treatment Outcome | 2006 |
Assessment of drug-drug interactions between tenofovir disoproxil fumarate and the nonnucleoside reverse transcriptase inhibitors nevirapine and efavirenz in HIV-infected patients.
Topics: Adenine; Administration, Oral; Alkynes; Benzoxazines; Cyclopropanes; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Nevirapine; Organophosphonates; Oxazines; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Tenofovir trials raise ethical issues.
Topics: Adenine; Clinical Trials as Topic; Ethics, Medical; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2005 |
Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
Topics: 2-Aminopurine; Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Caffeine; Cell Survival; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Dihydropyridines; Dose-Response Relationship, Drug; Female; Flavins; Humans; Interleukin-10; Lipopolysaccharides; Macrophage Inflammatory Proteins; Macrophages; Mice; Mice, Inbred C57BL; Molecular Structure; Organophosphonates; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Theophylline; Triazoles; Tumor Necrosis Factor-alpha | 2006 |
[Simply convincing. New fixed combination for HIV therapy].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Clinical Trials as Topic; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Patient Compliance; Practice Guidelines as Topic; Survival Rate; Tenofovir | 2005 |
Clinical and virological effects during two years of ongoing adefovir dipivoxil in the treatment of lamivudine-resistant chronic hepatitis B infection.
Topics: Adenine; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Renal Dialysis; Treatment Failure; Virus Replication | 2005 |
Study on the efficacy and safety of adefovir dipivoxil treatment in post-liver transplant patients with hepatitis B virus infection and lamivudine-resistant hepatitis B virus.
Topics: Adenine; Alanine Transaminase; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis C; Humans; Lamivudine; Liver Transplantation; Male; Organophosphonates; Recurrence; Retrospective Studies; Safety | 2005 |
Anti-HBV nucleotide prodrug analogs: synthesis, bioreversibility, and cytotoxicity studies.
Topics: Adenine; Animals; Antiviral Agents; Cattle; Drug-Related Side Effects and Adverse Reactions; Hepatitis B virus; Oligodeoxyribonucleotides; Organophosphonates; Prodrugs; Rabbits; Reverse Transcriptase Inhibitors; Swine; Virus Replication | 2006 |
Should tenofovir ever be used in association with didanosine?
Topics: Adenine; Anti-HIV Agents; Contraindications; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure; Viral Load | 2005 |
In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes.
Topics: Adenine; Animals; Antiviral Agents; Catechols; Cytochrome P-450 Enzyme System; Female; Microsomes, Liver; Nitrophenols; Organophosphonates; Rats; Rats, Inbred Lew; RNA, Messenger | 2006 |
Wild type and YMDD variant of hepatitis B virus: no difference in viral kinetics on lamivudine/tenofovir therapy in HIV-HBV co-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; DNA, Viral; Drug Resistance, Viral; Genetic Variation; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Kinetics; Lamivudine; Male; Middle Aged; Organophosphonates; RNA, Viral; Tenofovir | 2006 |
Minor changes in calculated creatinine clearance and anion-gap are associated with tenofovir disoproxil fumarate-containing highly active antiretroviral therapy.
Topics: Acid-Base Equilibrium; Acute Kidney Injury; Adenine; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Creatinine; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Kidney; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Cost-effectiveness analysis of lamivudine and adefovir dipivoxil in the treatment of patients with HBeAg-negative chronic hepatitis B.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Cost-Benefit Analysis; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Spain | 2006 |
Case study: an active, 24-year-old woman positive for HIV.
Topics: Adenine; Adult; Anti-Retroviral Agents; Deoxycytidine; Disease Progression; Emtricitabine; Female; HIV Infections; Humans; Organophosphonates; Ritonavir; Tenofovir | 2006 |
Synthesis of 9-[1-(substituted)-3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents.
Topics: Adenine; Antiviral Agents; Hepacivirus; Humans; Organophosphonates; Prodrugs; Virus Replication | 2005 |
Synthesis of 9-[1-(substituted)-2-(phosphonomethoxy)ethyl]adenine derivatives as possible antiviral agents.
Topics: Adenine; Antiviral Agents; Hepacivirus; Humans; Organophosphonates; Prodrugs; Virus Replication | 2005 |
Synthesis of 9-[1-(1 -hydroxyethyl)-3-(phosphonomethoxy)propyl]adenine and prodrug as possible antiviral agents.
Topics: Adenine; Animals; Antiviral Agents; Hepacivirus; Organophosphonates; Prodrugs; Virus Replication | 2005 |
Synthesis of N6-substituted 9-[3-(phosphonomethoxy)propyl]adenine derivatives as possible antiviral agents.
Topics: Adenine; Antiviral Agents; Hepacivirus; Humans; Organophosphonates; Prodrugs; Virus Replication | 2005 |
Longitudinal study on mitochondrial effects of didanosine-tenofovir combination.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Didanosine; DNA, Mitochondrial; Drug Therapy, Combination; Electron Transport Complex IV; HIV Infections; HIV-1; Humans; Longitudinal Studies; Organophosphonates; Oxidative Phosphorylation; Prospective Studies; Retrospective Studies; Tenofovir | 2006 |
DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued.
Topics: Adenine; Animals; Anti-HIV Agents; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Cell Proliferation; Disease Progression; Epitopes, T-Lymphocyte; Gene Products, gag; Gene Products, tat; Immunotherapy, Active; Macaca mulatta; Organophosphonates; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Statistics as Topic; Tenofovir; Vaccines, DNA; Viremia; Withholding Treatment | 2006 |
Adefovir therapy for lamivudine escape and hepatitis B virus reactivation after reduced intensity conditioning allogeneic stem cell transplantation.
Topics: Adenine; Adult; Antineoplastic Agents; Combined Modality Therapy; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Leukemia, Myeloid, Acute; Organophosphonates; Stem Cell Transplantation; Transplantation Conditioning; Transplantation, Homologous; Treatment Outcome; Viral Load; Virus Activation | 2006 |
[Lamivudine and adefovir resistance in a patient with HBeAg negative chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load | 2006 |
Resistance to adefovir dipivoxil in lamivudine resistant chronic hepatitis B patients treated with adefovir dipivoxil.
Topics: Adenine; Adult; Drug Resistance, Viral; Female; Genotype; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Phenotype; Retrospective Studies; Reverse Transcriptase Inhibitors | 2006 |
Adefovir dipivoxil-associated thrombocytopenia in a patient with chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Thrombocytopenia | 2006 |
Chronic hepatitis B: a critical appraisal of current approaches to therapy.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Biopsy; Clinical Competence; Disease Progression; DNA, Viral; Drug Therapy, Combination; Endpoint Determination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Liver; Organophosphonates; Patient Selection; Polyethylene Glycols; Recombinant Proteins; Societies, Medical; Virus Replication | 2006 |
Combination therapy for chronic hepatitis B: a one-two knockout punch, or a swing and a miss?
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2006 |
Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants.
Topics: Adenine; Adult; DNA, Viral; Drug Resistance, Viral; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis, Autoimmune; Humans; Lamivudine; Liver Transplantation; Male; Mutation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors | 2006 |
Replacement of tenofovir with adefovir may result in reactivation of hepatitis B virus replication.
Topics: Adenine; Antiviral Agents; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2006 |
Retrovirus meeting. Novel attacks on HIV move closer to reality.
Topics: Adenine; Animals; Anti-HIV Agents; Evolution, Molecular; HIV Infections; HIV-1; Humans; Organic Chemicals; Organophosphonates; Primates; Pyrrolidinones; Raltegravir Potassium; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2006 |
Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
Topics: Adenine; Adenosine Triphosphate; Bone and Bones; Carbon; Catalytic Domain; Cyclin-Dependent Kinase 2; Drug Design; Enzyme Inhibitors; Humans; Ligands; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Models, Molecular; Neoplasms; Nitrogen; Organophosphonates; Protein Conformation; Purines; Pyrimidines; src-Family Kinases; Structure-Activity Relationship; Substrate Specificity | 2006 |
In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine.
Topics: Adenine; Animals; Antiviral Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Resistance, Viral; Ducks; Filaggrin Proteins; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatocytes; Humans; Lamivudine; Liver Neoplasms; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Virus Replication | 2006 |
Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV-infected patients.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome | 2006 |
N6-methyl-AMP aminohydrolase activates N6-substituted purine acyclic nucleoside phosphonates.
Topics: Adenine; Aminohydrolases; Animals; Catalysis; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Guanine; In Vitro Techniques; Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley | 2006 |
Serum creatinine changes in HIV-seropositive patients receiving tenofovir.
Topics: Acute Kidney Injury; Adenine; Creatinine; Cross-Sectional Studies; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
[Chronic hepatitis B: from old braids and new brooms].
Topics: Adenine; Antiviral Agents; Germany; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Medicine in the Arts; Models, Anatomic; Mutation; Organophosphonates; Prognosis; Sculpture; Viral Load | 2005 |
Sensitive line probe assay that simultaneously detects mutations conveying resistance to lamivudine and adefovir.
Topics: Adenine; Antiviral Agents; Base Sequence; DNA Probes; DNA, Viral; Drug Resistance, Viral; Genes, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; In Vitro Techniques; Lamivudine; Mutation; Organophosphonates; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Sensitivity and Specificity; Virology | 2006 |
Exploring mitochondrial nephrotoxicity as a potential mechanism of kidney dysfunction among HIV-infected patients on highly active antiretroviral therapy.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biopsy; Didanosine; DNA, Mitochondrial; Drug Therapy, Combination; Female; HIV Infections; Humans; Kidney; Male; Microscopy, Electron; Middle Aged; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2006 |
First report of genotypic resistance to adefovir in chronic HBV in the Republic of Ireland.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Humans; Ireland; Male; Mutation; Organophosphonates | 2006 |
Registration problems for antiretrovirals in Africa.
Topics: Adenine; Africa; Anti-Retroviral Agents; Developing Countries; Drug and Narcotic Control; HIV Infections; Humans; Organophosphonates; Tenofovir | 2006 |
Suboptimal CD4 gains in HIV-infected patients receiving didanosine plus tenofovir.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Didanosine; Drug Interactions; HIV Infections; Humans; Mitochondria; Organophosphonates; Purine-Nucleoside Phosphorylase; Tenofovir | 2006 |
Synthesis and antiviral evaluation of alkoxyalkyl derivatives of 9-(S)-(3-hydroxy-2-phosphonomethoxypropyl)adenine against cytomegalovirus and orthopoxviruses.
Topics: Adenine; Antiviral Agents; Cell Line; Cytomegalovirus; Esters; Humans; Organophosphonates; Orthopoxvirus; Stereoisomerism; Structure-Activity Relationship | 2006 |
Clinical and genotypic correlates of mutation K65R in HIV-infected patients failing regimens not including tenofovir.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Drug Resistance, Viral; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Multivariate Analysis; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure | 2006 |
Virological response to HIV-1 nucleoside/nucleotide reverse transcriptase inhibitors-based, tenofovir DF-including regimens in the ANRS Aquitaine Cohort.
Topics: Adenine; Cohort Studies; Didanosine; Dideoxynucleosides; Drug Therapy, Combination; France; HIV Infections; HIV Reverse Transcriptase; HIV-1; Hospitals, University; Humans; Lamivudine; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Species Specificity; Tenofovir; Treatment Outcome; Viral Load; Zidovudine | 2006 |
Improvement of dyslipidemia during different HAART regimens: tenofovir- versus stavudine-containing antiretroviral combinations.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dyslipidemias; HIV Infections; Humans; Organophosphonates; Stavudine; Tenofovir | 2006 |
Antiviral options for the treatment of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates | 2006 |
Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
Topics: Adenine; Animals; Antiviral Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Female; Lymphocytes; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors | 2005 |
Switching to adefovir monotherapy after emergence of lamivudine-resistant mutations in patients with liver cirrhosis.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Bilirubin; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Serum Albumin; Statistics, Nonparametric | 2006 |
Tenofovir for chronic hepatitis B virus infection in HIV-coinfected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Clinical Trials as Topic; Hepatitis B e Antigens; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2006 |
Short-term safety and tolerability of didanosine combined with high- versus low-dose tenofovir disproxil fumarate in ambulatory HIV-1-infected persons.
Topics: Adenine; Adult; Anti-HIV Agents; Didanosine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Organophosphonates; Retrospective Studies; Tenofovir | 2006 |
Higher risk of hyperglycemia in HIV-infected patients treated with didanosine plus tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Blood Glucose; Didanosine; Drug Therapy, Combination; Fasting; Female; Follow-Up Studies; HIV Infections; Humans; Hyperglycemia; Linear Models; Male; Organophosphonates; Retrospective Studies; Risk Factors; RNA, Viral; Tenofovir; Time Factors; Treatment Outcome; Virus Replication | 2006 |
Prophylactic strategies for hepatitis B patients undergoing liver transplant: a cost-effectiveness analysis.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Health Care Costs; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Markov Chains; Middle Aged; Organophosphonates; Recurrence | 2006 |
Antiviral efficacy and genotypic resistance patterns of combination therapy with stavudine/tenofovir in highly active antiretroviral therapy experienced patients.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biological Evolution; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; RNA, Viral; Stavudine; Tenofovir; Treatment Failure; Viral Load | 2006 |
Neuropsychiatric adverse events after switching from an antiretroviral regimen containing efavirenz without tenofovir to an efavirenz regimen containing tenofovir: a report of nine cases.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Dizziness; Dreams; Drug Therapy, Combination; Female; Humans; Irritable Mood; Male; Middle Aged; Nausea; Organophosphonates; Oxazines; Sleep Initiation and Maintenance Disorders; Tenofovir; Tinnitus | 2006 |
The K65R mutation in human immunodeficiency virus type 1 reverse transcriptase exhibits bidirectional phenotypic antagonism with thymidine analog mutations.
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Arginine; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Lysine; Organophosphonates; Phenotype; Point Mutation; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine; Zalcitabine; Zidovudine | 2006 |
Variant of hepatitis B virus with primary resistance to adefovir.
Topics: Adenine; Amino Acid Sequence; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Viremia | 2006 |
Comparison of growth and differentiation of fetal and adult rhesus monkey mesenchymal stem cells.
Topics: Adenine; Adipocytes; Animals; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chondrocytes; Culture Media; Dose-Response Relationship, Drug; Fetus; Fibroblast Growth Factor 2; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Macaca mulatta; Mesenchymal Stem Cells; Organophosphonates; Osteoblasts; Platelet-Derived Growth Factor; Reverse Transcriptase Inhibitors; Spumavirus; Tenofovir; Time Factors | 2006 |
Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors | 2006 |
Tenofovir-associated kidney diseases and interactions between tenofovir and other antiretrovirals.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Drug Interactions; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2006 |
The role of drug interactions and monitoring in the prevention of tenofovir-associated kidney disease.
Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; Drug Interactions; HIV Infections; Humans; Organophosphonates; Tenofovir | 2006 |
Relationship between antiretrovirals used as part of a cART regimen and CD4 cell count increases in patients with suppressed viremia.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load; Viremia; Zidovudine | 2006 |
Adefovir dipivoxil monotherapy is a sufficiently effective treatment modality for Japanese patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Japan; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome | 2006 |
Investigating new antiretroviral combinations.
Topics: Adenine; Anti-HIV Agents; Dideoxynucleosides; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Organophosphonates; Pilot Projects; Randomized Controlled Trials as Topic; Tenofovir | 2006 |
Indian pressure group challenges company's right to patent AIDS drug.
Topics: Adenine; Anti-HIV Agents; Drugs, Generic; Humans; India; Organophosphonates; Patents as Topic; Tenofovir | 2006 |
Comment on: suboptimal CD4 gains in HIV-infected patients receiving didanosine plus tenofovir.
Topics: Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Didanosine; HIV Infections; Humans; Organophosphonates; Purine-Nucleoside Phosphorylase; Tenofovir | 2006 |
Report from the 13th retrovirus conference. Renal tenofovir debate continues.
Topics: Adenine; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Truvada trials hold promise for new HIV prevention strategy. Once-a-day might keep HIV away.
Topics: Adenine; Centers for Disease Control and Prevention, U.S.; Clinical Trials as Topic; Female; HIV Infections; HIV Seronegativity; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; United States | 2006 |
Increased risk of adefovir resistance in patients with lamivudine-resistant chronic hepatitis B after 48 weeks of adefovir dipivoxil monotherapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; Base Sequence; Case-Control Studies; DNA, Viral; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Multiple; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Mutation; Organophosphonates; Pharmacogenetics; Probability; Reverse Transcriptase Polymerase Chain Reaction; Risk Assessment; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome; Viral Load | 2006 |
[The change of HBV nucleotide sequence during Adefovir dipivoxil treatment].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Point Mutation; Sequence Analysis, DNA | 2006 |
[The use of nucleotide analogues in treating patients with chronic hepatitis B].
Topics: Adenine; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2006 |
[Problems of and strategies in nucleotide analogues therapy for chronic hepatitis B].
Topics: Adenine; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2006 |
Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N6-substituted derivatives.
Topics: Adenine; Animals; Caffeine; Cell Survival; Cytokines; Dihydropyridines; Dose-Response Relationship, Drug; Female; Gene Expression; Interferon-gamma; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Nucleotides; Organophosphonates; Organophosphorus Compounds; Purinergic P1 Receptor Antagonists; Quinazolines; Receptors, Purinergic P1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triazoles | 2006 |
American Association for Cancer Research--97th annual meeting.
Topics: Adenine; Animals; Antineoplastic Agents; Benzoquinones; Glioblastoma; HSP90 Heat-Shock Proteins; Humans; Indoles; Janus Kinase 2; Lactams, Macrocyclic; Neoplasms, Experimental; Organophosphonates; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Topotecan; Tyrphostins | 2006 |
[Reactivation of hepatitis B treated with adefovir after infliximab administration].
Topics: Adenine; Antibodies, Monoclonal; Antiviral Agents; Hepatitis B; Humans; Immunosuppressive Agents; Infliximab; Male; Middle Aged; Organophosphonates; Psoriasis; Recurrence | 2006 |
Tubular transporters and clearance of adefovir.
Topics: Adenine; Animals; ATP-Binding Cassette Transporters; Biological Transport; Chromatography, High Pressure Liquid; Coproporphyrins; Immunosuppressive Agents; Kidney Tubules; Male; Metabolic Clearance Rate; Models, Biological; Mutation; Organic Anion Transport Protein 1; Organophosphonates; Probenecid; Rats; Rats, Wistar; Time Factors; Uricosuric Agents | 2006 |
Detection of rtN236T and rtA181V/T mutations associated with resistance to adefovir dipivoxil in samples from patients with chronic hepatitis B virus infection by the INNO-LiPA HBV DR line probe assay (version 2).
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Microbial Sensitivity Tests; Mutation; Nucleic Acid Hybridization; Oligonucleotide Probes; Organophosphonates; Reagent Kits, Diagnostic; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sensitivity and Specificity; Sequence Analysis, DNA | 2006 |
FDA makes final approvals.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Approval; Drug Combinations; Emtricitabine; HIV Infections; Humans; Organophosphonates; Tenofovir; United States; United States Food and Drug Administration | 2006 |
In vitro evaluation of the anti-HIV activity and metabolic interactions of tenofovir and emtricitabine.
Topics: Adenine; Anti-HIV Agents; Cell Line; Cell Line, Tumor; Cells, Cultured; Deoxycytidine; Drug Synergism; Emtricitabine; HIV-1; Humans; Lamivudine; Leukocytes, Mononuclear; Microbial Sensitivity Tests; Organophosphonates; Reverse Transcriptase Inhibitors; T-Lymphocytes; Tenofovir | 2006 |
Tenofovir DF and emtricitabine vs. zidovudine and lamivudine.
Topics: Adenine; Anti-Retroviral Agents; Bias; Data Interpretation, Statistical; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Lamivudine; Organophosphonates; Research Design; Tenofovir; Zidovudine | 2006 |
Renal safety of tenofovir disoproxil fumarate in HIV-1 treatment-experienced patients with adverse events related to prior NRTI use: data from a prospective, observational, multicenter study.
Topics: Adenine; Adult; HIV Infections; HIV-1; Humans; Kidney; Middle Aged; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Virologic and immunologic efficacy of the tenofovir/didanosine/lamivudine regimen.
Topics: Adenine; CD4 Lymphocyte Count; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Influence of tenofovir, nevirapine and efavirenz on ritonavir-boosted atazanavir pharmacokinetics in HIV-infected patients.
Topics: Adenine; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Drug Interactions; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Male; Nevirapine; Oligopeptides; Organophosphonates; Oxazines; Pyridines; Retrospective Studies; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir | 2006 |
Tenofovir DF and emtricitabine vs. zidovudine and lamivudine.
Topics: Adenine; Bone Density; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; HIV; HIV Infections; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2006 |
Development and validation of a sensitive LC-MS/MS method for the determination of adefovir in human serum and urine.
Topics: Adenine; Adult; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Humans; Male; Mass Spectrometry; Organophosphonates; Sensitivity and Specificity | 2006 |
Nephrotoxicity in a child with perinatal HIV on tenofovir, didanosine and lopinavir/ritonavir.
Topics: Adenine; Anti-HIV Agents; Child; Diabetes Insipidus, Nephrogenic; Didanosine; Drug Therapy, Combination; Fanconi Syndrome; Female; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Kidney Diseases; Lopinavir; Organophosphonates; Pregnancy; Pregnancy Complications; Pyrimidinones; Ritonavir; Tenofovir | 2006 |
Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques.
Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Biomarkers; Drug Resistance, Viral; Immune Tolerance; Macaca mulatta; Organophosphonates; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Virus Replication | 2006 |
Sustained improvement of dyslipidaemia in HAART-treated patients replacing stavudine with tenofovir.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cardiovascular Diseases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Dyslipidemias; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Risk Factors; Stavudine; Tenofovir | 2006 |
[To evaluate treatments of chronic hepatitis B].
Topics: Adenine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates | 2006 |
FDA notifications. Two tenofovir containing products are approved.
Topics: Adenine; Drug Approval; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2006 |
Intracellular metabolism and in vitro activity of tenofovir against hepatitis B virus.
Topics: Adenine; Antiviral Agents; Cell Line; Cells, Cultured; Drug Resistance, Viral; Hepatitis B virus; Hepatocytes; Humans; Organophosphonates; Phosphorylation; Tenofovir | 2006 |
Activities of alkoxyalkyl esters of cidofovir (CDV), cyclic CDV, and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine against orthopoxviruses in cell monolayers and in organotypic cultures.
Topics: Adenine; Antiviral Agents; Cells, Cultured; Cidofovir; Cyclization; Cytopathogenic Effect, Viral; Cytosine; Esters; Fibroblasts; Humans; Keratinocytes; Organophosphonates; Orthopoxvirus | 2006 |
[Comparison of clinical outcome between patients continuing and discontinuing lamivudine therapy in acute exacerbation after viral breakthrough during lamivudine therapy in chronic hepatitis B].
Topics: Acute Disease; Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2006 |
Moving toward assured access to treatment in microbicide trials. Global Campaign for Microbicides.
Topics: Adenine; Anti-HIV Agents; Cambodia; Cameroon; Clinical Trials as Topic; Consensus Development Conferences as Topic; Global Health; Health Policy; Health Services Accessibility; HIV Infections; HIV Seropositivity; Humans; International Agencies; Nigeria; Organophosphonates; Patient Rights; Political Systems; Politics; Randomized Controlled Trials as Topic; Refusal to Treat; Risk-Taking; Social Justice; Tenofovir; United Nations | 2006 |
Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus.
Topics: Adenine; Administration, Oral; Administration, Topical; Alanine; Animals; Anti-HIV Agents; Genetic Predisposition to Disease; Macaca mulatta; Organophosphonates; Prodrugs; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Virulence | 2006 |
Impact of modelling intra-subject variability on tests based on non-linear mixed-effects models in cross-over pharmacokinetic trials with application to the interaction of tenofovir on atazanavir in HIV patients.
Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; Bias; Cross-Over Studies; Drug Interactions; France; HIV Infections; Humans; Likelihood Functions; Nonlinear Dynamics; Oligopeptides; Organophosphonates; Pyridines; Tenofovir | 2007 |
HIV-1 subtype C viruses rapidly develop K65R resistance to tenofovir in cell culture.
Topics: Adenine; Didanosine; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Genetic Variation; Genotype; HIV-1; Humans; Inhibitory Concentration 50; Lamivudine; Microbial Sensitivity Tests; Organophosphonates; Polymorphism, Genetic; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Tenofovir; Time Factors | 2006 |
Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells.
Topics: Adenine; Chromatography, Liquid; Drug Stability; Humans; Leukocytes, Mononuclear; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Tenofovir | 2006 |
Hepatitis B virus with primary resistance to adefovir.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Viral Load | 2006 |
AIDS drug trial turned away; protests by prostitutes in Cambodia ended Tenofovir testing.
Topics: Adenine; Anti-HIV Agents; Cambodia; Clinical Trials as Topic; Developing Countries; Female; HIV Infections; Humans; Internationality; Organophosphonates; Refusal to Participate; Reverse Transcriptase Inhibitors; Sex Work; Tenofovir; Women | 2006 |
Hypokalemia in HIV patients on tenofovir.
Topics: Adenine; Adolescent; Adult; Body Weight; Child; Didanosine; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hypokalemia; Kidney Diseases; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Ritonavir; Tenofovir; Time Factors | 2006 |
Alkoxyalkyl esters of (S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine are potent inhibitors of the replication of wild-type and drug-resistant human immunodeficiency virus type 1 in vitro.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Cell Count; Cell Line; Cell Survival; DNA, Viral; Drug Resistance, Viral; Esters; Fibroblasts; Genetic Variation; HIV Infections; HIV-1; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Molecular Structure; Mutation; Organophosphonates; Virus Replication | 2006 |
Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy.
Topics: Adenine; Adult; Disease Progression; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Gene Products, pol; Genotype; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Virus Replication | 2006 |
Adefovir dipivoxyl for the treatment of delta-related liver cirrhosis.
Topics: Adenine; Female; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Liver Cirrhosis; Middle Aged; Organophosphonates | 2006 |
Effects of monotherapy with (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) on the evolution of a primary Simian immunodeficiency virus (SIV) isolate.
Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular; Genome, Viral; Genotype; Glycosylation; Heteroduplex Analysis; Humans; Macaca mulatta; Molecular Sequence Data; Organophosphonates; Sequence Homology; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir; Viral Load; Virus Replication | 2006 |
[Tubular transporters OAT1 and MRP2 and clearance of adefovir].
Topics: Adenine; Animals; Antiviral Agents; Kidney; Male; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Probenecid; Rats; Rats, Wistar; Uricosuric Agents | 2005 |
Rapid improvement of liver function in a patient with HIV and hepatitis B coinfection treated with lamivudine and tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Hepatitis; HIV Infections; Humans; Lamivudine; Liver Function Tests; Organophosphonates; Tenofovir; Zidovudine | 2006 |
Efavirenz/emtricitabine/tenofovir disoproxil fumarate: triple combination tablet.
Topics: Adenine; Alkynes; Benzoxazines; Clinical Trials as Topic; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2006 |
Urinary beta2-microglobulin as a possible sensitive marker for renal injury caused by tenofovir disoproxil fumarate.
Topics: Adenine; Adult; Anti-HIV Agents; beta 2-Microglobulin; Biomarkers; Creatinine; Female; HIV Infections; HIV-1; Humans; Kidney Tubules; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrimidinones; Tenofovir; Thinness | 2006 |
Favorable outcome of liver transplantation despite a high hepatitis B virus replication: beyond the limits?
Topics: Adenine; Antiviral Agents; Contraindications; Hepatitis B; Humans; Liver Transplantation; Male; Middle Aged; Organophosphonates; Treatment Outcome; Virus Replication | 2006 |
Evaluation of hypophosphataemia in tenofovir disoproxil fumarate (TDF)-exposed and TDF-unexposed HIV-infected out-patients receiving highly active antiretroviral therapy.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Hypophosphatemia; Incidence; Male; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir; Treatment Outcome; United States | 2006 |
Estimating renal function in patients on tenofovir disoproxil fumarate: suggestions for safer use.
Topics: Adenine; Creatinine; Dose-Response Relationship, Drug; Fanconi Syndrome; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Organophosphonates; Osteomalacia; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
HIV-associated nephropathy and drug-induced renal injury.
Topics: Adenine; AIDS-Associated Nephropathy; Anti-HIV Agents; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Tenofovir | 2006 |
Acute renal failure in HIV patients with liver cirrhosis receiving tenofovir: a report of two cases.
Topics: Acute Kidney Injury; Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Liver Cirrhosis; Male; Organophosphonates; Tenofovir | 2006 |
In vitro cytotoxicity and mitochondrial toxicity of tenofovir alone and in combination with other antiretrovirals in human renal proximal tubule cells.
Topics: Adenine; Anti-HIV Agents; Cell Survival; Cells, Cultured; Didanosine; DNA, Mitochondrial; Drug Interactions; Electron Transport Complex IV; Humans; Kidney Tubules, Proximal; Lopinavir; Mitochondria; Organophosphonates; Pyrimidinones; Ritonavir; RNA; Tenofovir; Zidovudine | 2006 |
Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer.
Topics: Adenine; Animals; Antibodies, Monoclonal; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; DNA, Complementary; Drug Interactions; Enzyme Induction; Hepatocytes; Humans; Isoenzymes; Ketoconazole; Microsomes, Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats | 2006 |
Change to a once-daily combination including boosted atazanavir in HIV-1-infected children.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Atazanavir Sulfate; Child; Drug Administration Schedule; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Ritonavir; Tenofovir; Virus Replication | 2006 |
Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biopsy; DNA, Circular; DNA, Viral; Drug Carriers; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Pilot Projects; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Treatment Outcome | 2006 |
Hepatitis delta virus super-infection in a co-infected patient with the human immunodeficiency virus type 1 and a surface antigen-negative hepatitis B virus variant.
Topics: Adenine; Alanine Transaminase; Amino Acid Sequence; Anti-HIV Agents; Follow-Up Studies; Hepatitis B; Hepatitis B virus; Hepatitis D; HIV Infections; HIV-1; Homosexuality, Male; Humans; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; RNA, Viral; Superinfection; Tenofovir; Time Factors; Viral Load | 2006 |
Chemoprophylaxis of HIV infection: moving forward with caution.
Topics: Adenine; Animals; Antiviral Agents; Chemoprevention; Disease Models, Animal; HIV Infections; HIV-1; Humans; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2006 |
Chemoprophylaxis with tenofovir disoproxil fumarate provided partial protection against infection with simian human immunodeficiency virus in macaques given multiple virus challenges.
Topics: Adenine; Animals; Anti-HIV Agents; Chemoprevention; Disease Models, Animal; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Macaca mulatta; Male; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2006 |
Short communication metabolic and mitochondrial effects of switching antiretroviral-experienced patients to enfuvirtide, tenofovir and saquinavir/ritonavir.
Topics: Adenine; Adult; Aged; Antiretroviral Therapy, Highly Active; DNA, Mitochondrial; Electron Transport Complex III; Electron Transport Complex IV; Enfuvirtide; Female; HIV Envelope Protein gp41; HIV Fusion Inhibitors; HIV Infections; HIV Protease Inhibitors; Humans; Insulin; Leukocytes, Mononuclear; Male; Middle Aged; Mitochondria; Organophosphonates; Oxygen Consumption; Peptide Fragments; Prospective Studies; Reverse Transcriptase Inhibitors; Ritonavir; Saquinavir; Tenofovir | 2006 |
Temporary HBV resolution in an HIV-coinfected patient during HBV-directed combination therapy followed by relapse of HBV.
Topics: Adenine; Adult; Antiviral Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; HIV Infections; HIV-1; Humans; Interferon alpha-2; Interferon-alpha; Male; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Secondary Prevention; Viral Load | 2006 |
Combined antiviral-immunosuppressive treatment in human T-lymphotrophic virus 1-Sjögren-associated myelopathy.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Female; HTLV-I Infections; Humans; Immunosuppressive Agents; Lamivudine; Magnetic Resonance Imaging; Methylprednisolone; Middle Aged; Organophosphonates; Prednisone; Radiography; Sjogren's Syndrome; Tenofovir | 2006 |
In vitro human immunodeficiency virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Emtricitabine; Genome, Bacterial; HIV-1; Humans; In Vitro Techniques; Lamivudine; Mutagenesis, Site-Directed; Mutation; Organophosphonates; Selection, Genetic; Sequence Analysis, DNA; Tenofovir | 2006 |
Emergence of a novel lamivudine-resistant hepatitis B virus variant with a substitution outside the YMDD motif.
Topics: Adenine; Amino Acid Motifs; Animals; Antiviral Agents; Blotting, Southern; Cloning, Molecular; DNA, Viral; Drug Resistance, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Mice; Mutation; Organophosphonates; Plasmids; Polymorphism, Restriction Fragment Length; RNA, Viral; Transfection; Virus Replication | 2006 |
Long-term follow-up of patients with initial early virologic failure after being treated with once-daily tenofovir/abacavir/lamivudine.
Topics: Adenine; Anti-HIV Agents; Dideoxynucleosides; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Follow-Up Studies; HIV; HIV Infections; Humans; Lamivudine; Organophosphonates; RNA, Viral; Tenofovir; Treatment Failure | 2006 |
The role of tenofovir in the prevention of HIV infections.
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Organophosphonates; Tenofovir | 2006 |
Virological outcome of chronic hepatitis B virus infection in HIV-coinfected patients receiving anti-HBV active antiretroviral therapy.
Topics: Adenine; Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Chi-Square Distribution; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Regression Analysis; RNA, Viral; Statistics, Nonparametric; Tenofovir; Treatment Outcome | 2006 |
A rapid and sensitive real-time PCR assay for the K65R drug resistance mutation in SIV reverse transcriptase.
Topics: Adenine; Animals; Disease Models, Animal; Drug Resistance, Viral; Macaca; Microbial Sensitivity Tests; Organophosphonates; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sensitivity and Specificity; Simian Immunodeficiency Virus; Tenofovir | 2006 |
One pill, once daily: now an option for HIV patients.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Administration Schedule; Drug Combinations; HIV Infections; Humans; Organophosphonates; Oxazines; Tenofovir | 2006 |
A once-daily combination tablet (Atripla) for HIV.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Drug Interactions; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Emtricitabine; HIV Infections; Humans; Organophosphonates; Oxazines; Tenofovir | 2006 |
Mechanism of active renal tubular efflux of tenofovir.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Cell Line, Tumor; Dogs; Humans; Kidney Tubules, Proximal; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Favorable effect of adefovir on the number and functionality of myeloid dendritic cells of patients with chronic HBV.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antigens, CD; Antiviral Agents; Cytokines; Dendritic Cells; DNA, Viral; Female; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Lymphocyte Activation; Male; Middle Aged; Myeloid Cells; Organophosphonates; Viral Load | 2006 |
Nonresponse to adefovir: host or virus dependent?
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B; Hepatitis B virus; Humans; Organophosphonates; RNA, Viral; Treatment Failure; Viremia | 2006 |
Once-daily dosing and the treatment of HIV disease.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Emtricitabine; HIV Infections; Humans; Organophosphonates; Oxazines; Tenofovir | 2006 |
Acquired Fanconi's syndrome associated with tenofovir therapy.
Topics: Adenine; Adult; Fanconi Syndrome; Humans; Male; Organophosphonates; Tenofovir | 2006 |
Selection of a multiple drug-resistant hepatitis B virus strain in a liver-transplanted patient.
Topics: Adenine; Adult; Antiviral Agents; Biological Evolution; Cells, Cultured; Drug Resistance, Multiple; Drug Therapy, Combination; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; Virus Replication | 2006 |
Pre-exposure prophylaxis effective.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Drug Administration Schedule; Female; Ghana; HIV Infections; Humans; Organophosphonates; Tenofovir | 2006 |
Administration of fludarabine-loaded autologous red blood cells in simian immunodeficiency virus-infected sooty mangabeys depletes pSTAT-1-expressing macrophages and delays the rebound of viremia after suspension of antiretroviral therapy.
Topics: Adenine; Animals; Antiretroviral Therapy, Highly Active; Antiviral Agents; Cercocebus atys; Drug Carriers; Erythrocytes; Female; Humans; Macrophages; Male; Myeloablative Agonists; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; STAT1 Transcription Factor; T-Lymphocyte Subsets; Tenofovir; Vidarabine; Viremia; Virus Replication | 2006 |
Acyclic nucleoside phosphonates: past, present and future. Bridging chemistry to HIV, HBV, HCV, HPV, adeno-, herpes-, and poxvirus infections: the phosphonate bridge.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cytosine; Hepacivirus; Hepatitis B virus; HIV; Humans; Organophosphonates; Papillomaviridae; Poxviridae; Tenofovir; Virus Diseases; Viruses | 2007 |
Synthesis of beta-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases.
Topics: Adenine; Amino Acyl-tRNA Synthetases; Animals; Binding Sites; Cattle; Enzyme Inhibitors; Escherichia coli; Ketones; Liver; Molecular Conformation; Organophosphonates; Stereoisomerism; Structure-Activity Relationship | 2007 |
[A case of severe skin eruption caused by lamivudine in a patient with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Eruptions; Female; Hepatitis B, Chronic; Humans; Ichthyosis; Lamivudine; Middle Aged; Organophosphonates | 2006 |
Design and synthesis of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity.
Topics: Adenine; Antiviral Agents; Half-Life; Hepatitis B virus; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Organophosphonates; Prodrugs; Structure-Activity Relationship | 2007 |
Toward a pharmacogenetic understanding of nucleotide and nucleoside analogue toxicity.
Topics: Adenine; Anti-HIV Agents; Fanconi Syndrome; Haplotypes; HIV Infections; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Pharmacogenetics; Polymorphism, Single Nucleotide; Tenofovir | 2006 |
Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Case-Control Studies; Fanconi Syndrome; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; HIV Infections; Humans; Male; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Point Mutation; Polymorphism, Single Nucleotide; Statistics as Topic; Tenofovir | 2006 |
A novel hepatitis B virus mutation with resistance to adefovir but not to tenofovir in an HIV-hepatitis B virus-co-infected patient.
Topics: Adenine; Adult; Drug Resistance, Viral; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors.
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Cytidine Triphosphate; Dideoxynucleosides; Dideoxynucleotides; Drug Resistance, Multiple, Viral; Genotype; Glutamic Acid; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Lysine; Mutagenesis, Site-Directed; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir; Thymine Nucleotides; Zidovudine | 2007 |
Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2'-deoxyadenosine triphosphate by ion-pairing LC/MS/MS.
Topics: Adenine; Cell Line, Tumor; Chromatography, Liquid; Deoxyadenine Nucleotides; Humans; Immunosuppressive Agents; Organophosphonates; Phosphorylation; Reproducibility of Results; Tandem Mass Spectrometry | 2007 |
Functional involvement of multidrug resistance-associated protein 4 (MRP4/ABCC4) in the renal elimination of the antiviral drugs adefovir and tenofovir.
Topics: Adenine; Adenosine Triphosphate; Animals; Antiviral Agents; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Humans; Kidney; Mice; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Osmosis; Renal Insufficiency; Tenofovir; Tissue Distribution | 2007 |
HIV prophylaxis still has no clear cut answer.
Topics: Adenine; Centers for Disease Control and Prevention, U.S.; Female; HIV Infections; Humans; National Institutes of Health (U.S.); Organophosphonates; Placebos; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir; United States | 2006 |
Treatment of lamivudine-resistant hepatitis B infection in post-renal transplant patients with adefovir dipivoxil: preliminary results.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Follow-Up Studies; Hepatitis B; Hepatitis B Core Antigens; Humans; Kidney; Kidney Transplantation; Lamivudine; Middle Aged; Organophosphonates; Postoperative Complications | 2006 |
[Acute renal failure and proximal renal tubular dysfuntion in a patient with acquired immunodeficiency syndrome treated with tenofovir].
Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adenine; Aged; Anti-HIV Agents; Fanconi Syndrome; Female; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV-1; HIV-2; Humans; Mice; Moloney murine sarcoma virus; Organophosphonates; Pyrimidines; Retroviridae Infections; Sarcoma, Experimental; Structure-Activity Relationship; Tenofovir; Tumor Virus Infections | 2007 |
Successful treatment with adefovir of one patient whose cryoglobulinemic vasculitis relapsed under lamivudine therapy and who was diagnosed to have HBV virologic breakthrough with YMDD mutations.
Topics: Adenine; Amino Acid Motifs; Aspartic Acid; Cryoglobulinemia; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Methionine; Middle Aged; Mutation; Organophosphonates; Recurrence; Tyrosine; Vasculitis | 2006 |
Experimental approaches to studies on drug metabolism and drug interactions in man: interaction of acyclic nucleoside phosphonates with human liver cytochromes P450 and flavin-containing monooxygenase 3.
Topics: Adenine; Bacteria; Cell Membrane; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Liver; Metabolic Detoxication, Phase I; Models, Biological; NADPH-Ferrihemoprotein Reductase; Organophosphonates; Oxygenases; Research Design; Tenofovir; Transformation, Bacterial | 2006 |
Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir.
Topics: Adenine; Antiviral Agents; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Organophosphonates; Prodrugs; Tenofovir | 2006 |
Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Boranes; Boron Compounds; Chlorocebus aethiops; DNA Viruses; HIV-1; Humans; In Vitro Techniques; Nucleosides; Organophosphonates; Phosphates; RNA Viruses; Structure-Activity Relationship; Vero Cells; Virus Replication | 2006 |
Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques.
Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; CD8-Positive T-Lymphocytes; Chronic Disease; Drug Resistance, Viral; Macaca mulatta; Organophosphonates; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Virus Replication | 2006 |
Inhibition of viral replication reduces regulatory T cells and enhances the antiviral immune response in chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; CD4 Lymphocyte Count; Cell Division; Cells, Cultured; Female; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-gamma; Interleukin-10; Male; Middle Aged; Organophosphonates; T-Cell Antigen Receptor Specificity; T-Lymphocytes; T-Lymphocytes, Regulatory; Viral Load | 2007 |
In vitro evaluation of the anti-orf virus activity of alkoxyalkyl esters of CDV, cCDV and (S)-HPMPA.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Ecthyma, Contagious; Fibroblasts; Humans; In Vitro Techniques; Keratinocytes; Lung; Nucleosides; Orf virus; Organophosphonates; Prodrugs; Sensitivity and Specificity; Sheep | 2007 |
Report from the XVI International AIDS Conference. Preexposure prophylaxis studies move forward.
Topics: Adenine; Adolescent; Adult; Condoms; Double-Blind Method; Female; HIV Infections; Humans; Organophosphonates; Placebos; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Aminotransferase elevation in HIV/hepatitis B virus co-infected patients treated with two active hepatitis B virus drugs.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; DNA, Viral; Female; Hepatitis B; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Transaminases | 2006 |
Atripla approval in Europe.
Topics: Adenine; Alkynes; Antiviral Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Approval; Emtricitabine; Europe; Organophosphonates; Oxazines; Tenofovir | 2006 |
K65R development among subtype C HIV-1-infected patients in tenofovir DF clinical trials.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Mutation; Organophosphonates; Tenofovir; Treatment Failure | 2007 |
Rate of virologic failure and selection of drug resistance mutations using different triple nucleos(t)ide analogue combinations in HIV-infected patients.
Topics: Adenine; Adult; Anti-Retroviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure; Viral Load; Zidovudine | 2006 |
Multidrug resistance protein 4 protects bone marrow, thymus, spleen, and intestine from nucleotide analogue-induced damage.
Topics: Adenine; Animals; Bone Marrow; Brain; Drug Hypersensitivity; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multidrug Resistance-Associated Proteins; Organophosphonates; Spleen; Thymus Gland | 2007 |
Anti-HIV agents. Trying times for tenofovir and abacavir.
Topics: Adenine; Adult; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Organophosphonates; Tenofovir; Viral Load | 2003 |
Five-year data out on Viread.
Topics: Adenine; Anti-HIV Agents; Double-Blind Method; Drug Administration Schedule; HIV Infections; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Stavudine; Tenofovir | 2006 |
Anti-HIV agents. Low rate of early virologic failure seen with a combination of Trizivir and tenofovir.
Topics: Adenine; Dideoxynucleosides; Drug Combinations; Drug Therapy, Combination; HIV Infections; Humans; Lamivudine; Organophosphonates; Tenofovir; Viral Load; Zidovudine | 2004 |
COBAS AmpliPrep-COBAS TaqMan hepatitis B virus (HBV) test: a novel automated real-time PCR assay for quantification of HBV DNA in plasma.
Topics: Adenine; Antiviral Agents; Automation; Biopsy; DNA, Viral; Drug Resistance, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Nucleic Acid Amplification Techniques; Organophosphonates; Polymerase Chain Reaction; Sensitivity and Specificity; Taq Polymerase; Viremia | 2007 |
[The rate of hepatitis B virus resistance to adefovir dipivoxil (ADV) and the evolution of hepatitis B virus in lamivudine-resistant chronic hepatitis B patients with ADV monotherapy].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2007 |
Workshop explores racial PK differences, TDF-PI interaction.
Topics: Adenine; HIV Infections; HIV Protease Inhibitors; Humans; Organophosphonates; Racial Groups; Reverse Transcriptase Inhibitors; Tenofovir | 2006 |
Rescue therapy for lamivudine-resistant chronic hepatitis B: when and how?
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Salvage Therapy | 2007 |
Visual loss secondary to acquired immunodeficiency virus-related progressive multifocal leukoencephalopathy demonstrating clinical improvement with highly active antiretroviral therapy.
Topics: Adenine; AIDS-Related Opportunistic Infections; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cerebrospinal Fluid; Cyclopropanes; Drug Therapy, Combination; Hemianopsia; Humans; JC Virus; Lamivudine; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Male; Middle Aged; Organophosphonates; Oxazines; Tenofovir; Tomography, X-Ray Computed; Vision Disorders; Visual Fields | 2007 |
[Autoimmune thrombopenia associated with hepatitis B reactivation (reverse seroconversion) after autologous hematopoietic stem cell transplantation].
Topics: Adenine; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Hematopoietic Stem Cell Transplantation; Hepatitis B; Humans; Immunocompromised Host; Immunoglobulin G; Immunologic Factors; Lymphoma; Male; Middle Aged; Organophosphonates; Purpura, Thrombocytopenic, Idiopathic; Recurrence; Transplantation, Autologous; Treatment Outcome | 2007 |
In vitro susceptibility of six isolates of equine herpesvirus 1 to acyclovir, ganciclovir, cidofovir, adefovir, PMEDAP and foscarnet.
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Cell Survival; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Drug Resistance, Viral; Epithelial Cells; Foscarnet; Ganciclovir; Herpesvirus 1, Equid; Horses; Lung; Organophosphonates | 2007 |
Progressive multifocal leukoencephalopathy: serial high-b-value diffusion-weighted MR imaging and apparent diffusion coefficient measurements to assess response to highly active antiretroviral therapy.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brain; Diffusion; Diffusion Magnetic Resonance Imaging; HIV Protease Inhibitors; Humans; Leukoencephalopathy, Progressive Multifocal; Lopinavir; Male; Organophosphonates; Pyrimidinones; Ritonavir; Tenofovir; Zidovudine | 2007 |
Macroenzyme creatine kinase (CK) type 2 in HIV-infected patients is significantly associated with TDF and consists of ubiquitous mitochondrial CK.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Cohort Studies; Creatine Kinase, Mitochondrial Form; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2006 |
Unusual selection of rtA181V HBV mutants cross-resistant to adefovir following prolonged lamivudine monotherapy: report of two cases.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Hepatitis B virus; Humans; Lamivudine; Male; Mutation; Organophosphonates; Selection, Genetic | 2006 |
R16, a novel amonafide analogue, induces apoptosis and G2-M arrest via poisoning topoisomerase II.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Caspases; Cell Division; Cell Proliferation; Cytochromes c; DNA Topoisomerases, Type II; Enzyme Inhibitors; Female; Flow Cytometry; G2 Phase; Humans; Imides; In Situ Nick-End Labeling; Isoquinolines; Liver Neoplasms, Experimental; Mice; Mice, Inbred Strains; Naphthalimides; Organophosphonates; Poly(ADP-ribose) Polymerases; Sarcoma, Experimental; Thiophenes; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 2007 |
Why do we not yet have combination chemotherapy for chronic hepatitis B?
Topics: Adenine; Antibodies, Viral; Antiviral Agents; DNA, Viral; Drug Combinations; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Drug Synergism; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2007 |
Antiviral therapy for pre- and post-liver transplantation patients with hepatitis B.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Humans; Kidney Diseases; Lamivudine; Liver Transplantation; Organophosphonates; Secondary Prevention; Tenofovir | 2007 |
Editorial comment: tenofovir-related nephrotoxicity--who's at risk?
Topics: Adenine; Anti-HIV Agents; Drug Therapy, Combination; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Diseases; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir | 2007 |
Inhibition of HIV-1 replication in macrophages by a heterodinucleotide of lamivudine and tenofovir.
Topics: Adenine; Animals; Anti-HIV Agents; Chromatography, High Pressure Liquid; Culture Media; Erythrocytes; Female; HIV-1; Humans; In Vitro Techniques; Indicators and Reagents; Lamivudine; Macrophages; Mice; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2007 |
Induction therapy with enfuvirtide-based highly active antiretroviral therapy in a patient with acute HIV-1 infection.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Emtricitabine; Enfuvirtide; HIV Envelope Protein gp41; HIV Infections; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Peptide Fragments; Pyrimidinones; Ritonavir; Tenofovir; Viral Load; Viremia | 2007 |
Comparison of the inhibitory activity of anti-HIV drugs on P-glycoprotein.
Topics: Adenine; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Count; Cell Proliferation; Flow Cytometry; Fluoresceins; HIV Protease Inhibitors; Humans; Nelfinavir; Organophosphonates; Rhodamine 123; Tenofovir | 2007 |
Progress in the treatment of chronic hepatitis B: long-term experience with adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Phenotype | 2007 |
Treatment of patients with lamivudine-resistant and adefovir dipivoxil-resistant chronic hepatitis B virus infection: is tenofovir the answer?
Topics: Adenine; Adult; Drug Resistance, Multiple, Viral; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Therapeutic immunization with Modified Vaccinia Virus Ankara (MVA) vaccines in SIV-infected rhesus monkeys undergoing antiretroviral therapy.
Topics: Adenine; Animals; Anti-Retroviral Agents; Antibodies, Viral; Fusion Proteins, gag-pol; Genetic Vectors; Macaca mulatta; Organophosphonates; SAIDS Vaccines; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Vaccines, DNA; Vaccinia virus | 2007 |
Hepatitis B virus reactivation in a case of Waldenstrom's macroglobulinemia treated with chemotherapy and rituximab despite adefovir prophylaxis.
Topics: Adenine; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Female; Hepatitis B virus; Humans; Immunotherapy; Organophosphonates; Rituximab; Waldenstrom Macroglobulinemia | 2007 |
Tenofovir-induced kidney injury.
Topics: Adenine; Animals; Anti-HIV Agents; Humans; Kidney Diseases; Organophosphonates; Tenofovir | 2007 |
Synthesis and antiviral evaluation of alkoxyalkyl-phosphate conjugates of cidofovir and adefovir.
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cowpox; Cytomegalovirus Infections; Cytosine; Herpes Simplex; HIV-1; Humans; In Vitro Techniques; Molecular Structure; Organophosphonates; Sensitivity and Specificity; Vaccinia | 2007 |
No response to first-line tenofovir+lamivudine+efavirenz despite optimization according to baseline resistance testing: impact of resistant minority variants on efficacy of low genetic barrier drugs.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Resistance, Multiple, Viral; HIV Infections; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
[Use study of tenofovir DF in highly active anti-retroviral therapy].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2006 |
In vitro activity of 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]-pyrimidine against multidrug-resistant hepatitis B virus mutants.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Multiple, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Pyrimidine Nucleosides; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2007 |
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).
Topics: Adenine; Antiviral Agents; Cell Line; Cidofovir; Cytosine; Humans; Kidney; Kinetics; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Organophosphonates; Probenecid; Tenofovir; Transfection | 2007 |
Prevention. Anti-HIV drug could prevent transmission in women.
Topics: Adenine; Administration, Topical; Female; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Tailoring antiviral therapy in chronic hepatitis B patients with lamivudine resistance.
Topics: Adenine; Contraindications; Dose-Response Relationship, Drug; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2007 |
Unlikely association of multidrug-resistance protein 2 single-nucleotide polymorphisms with tenofovir-induced renal adverse events.
Topics: Adenine; Anti-HIV Agents; Confounding Factors, Epidemiologic; HIV Infections; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Point Mutation; Polymorphism, Single Nucleotide; Renal Insufficiency; Tenofovir | 2007 |
HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA).
Topics: Adenine; Administration, Cutaneous; Animals; Antiviral Agents; Chromatography, High Pressure Liquid; In Vitro Techniques; Organophosphonates; Reproducibility of Results; Skin; Skin Absorption; Spectrophotometry, Ultraviolet; Swine | 2007 |
Early virological suppression is associated with good maintained response to adefovir dipivoxil in lamivudine resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Hong Kong; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2007 |
Combination therapy in liver transplant recipients with hepatitis B virus without hepatitis B immune globulin.
Topics: Adenine; Adult; Aged; Antibodies, Viral; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Immunization, Passive; Immunoglobulins; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Secondary Prevention; Treatment Outcome | 2007 |
Decompensated lamivudine-resistant hepatitis B virus-related cirrhosis treated successfully with adefovir dipivoxil allowing surgery for hepatocellular carcinoma.
Topics: Adenine; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Disease Progression; Drug Resistance, Viral; Follow-Up Studies; Hepatectomy; Hepatitis B, Chronic; Humans; Immunohistochemistry; Lamivudine; Liver Cirrhosis; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2007 |
Long-term follow-up of patients taking tenofovir DF with low-level HIV-1 viremia and the K65R substitution in HIV-1 RT.
Topics: Adenine; Anti-HIV Agents; Anti-Retroviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Long-Term Care; Longitudinal Studies; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2007 |
Response to Schmutz et al., 'Combination of tenofovir and lamivudine versus tenofovir after lamivudine failure for therapy of hepatitis B in HIV-coinfection'.
Topics: Adenine; Drug Therapy, Combination; Hepatitis B; HIV Infections; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure | 2007 |
Response to Blaas et al., 'Acute renal failure in HIV patients with liver cirrhosis receiving tenofovir: a report of two cases'.
Topics: Acute Kidney Injury; Adenine; HIV Infections; Humans; Liver Cirrhosis; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection.
Topics: Adenine; Amino Acid Substitution; Animals; Anti-HIV Agents; CD8-Positive T-Lymphocytes; Disease Models, Animal; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Lymphocyte Depletion; Macaca; Mutation, Missense; Organophosphonates; RNA, Viral; Selection, Genetic; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load; Viremia | 2007 |
CD4+ T cell evolution and predictors of its trend before and after tenofovir/didanosine backbone in the presence of sustained undetectable HIV plasma viral load.
Topics: Adenine; Adult; Aging; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cohort Studies; Didanosine; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Italy; Male; Middle Aged; Organophosphonates; Risk Factors; Sex Characteristics; Tenofovir; Treatment Outcome; Viral Load | 2007 |
Evidence and possible consequences of the phosphorylation of nucleoside reverse transcriptase inhibitors in human red blood cells.
Topics: Adenine; Anti-HIV Agents; Drug Interactions; Drug Therapy, Combination; Erythrocytes; HIV Infections; Humans; Lamivudine; Nucleosides; Organophosphonates; Phosphorylation; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Zidovudine | 2007 |
Characteristics of patients with chronic hepatitis-B virus infection in an urban hospital.
Topics: Adenine; Adolescent; Adult; Black or African American; Contraindications; Female; Hepatitis B, Chronic; Hispanic or Latino; Hospitals, Urban; Humans; Insurance Coverage; Interferons; Lamivudine; Liver Cirrhosis; Male; Mass Screening; Middle Aged; New York City; Organophosphonates; Patient Compliance; Pilot Projects; Refusal to Treat; Risk Factors; Urban Health; Utilization Review | 2007 |
Medicines Control Council and registration backlog of antiretrovirals.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Drug Approval; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Oxazines; South Africa | 2007 |
Possible allergic cross-reaction to didanosine and tenofovir in an HIV-1-infected woman.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Didanosine; Drug Hypersensitivity; Drug Interactions; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Tenofovir | 2007 |
Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimens.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Black People; Cholesterol; Cross-Sectional Studies; Cyclopropanes; Didanosine; Dideoxynucleosides; Drug Therapy, Combination; Fasting; Female; Hispanic or Latino; HIV Infections; HIV Protease Inhibitors; HIV Seronegativity; HIV Seropositivity; HIV-1; Humans; Indinavir; Lamivudine; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Multivariate Analysis; Nelfinavir; Nevirapine; Organophosphonates; Ritonavir; Stavudine; Tenofovir; Triglycerides; United States; White People | 2007 |
Could tenofovir modify the model end-stage liver disease (MELD) score in patients with end-stage liver disease eligible for liver transplantation?
Topics: Adenine; Anti-HIV Agents; Humans; Liver Failure; Liver Transplantation; Organophosphonates; Severity of Illness Index; Tenofovir | 2007 |
Tenofovir and abacavir combination therapy: lessons learned from an urban clinic population.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Aged; Anti-HIV Agents; Baltimore; Dideoxynucleosides; Drug Therapy, Combination; Female; Humans; Male; Medical Records; Middle Aged; Multicenter Studies as Topic; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Failure; Urban Population; Viral Load | 2007 |
Acute interstitial nephritis of HIV-positive patients under atazanavir and tenofovir therapy in a retrospective analysis of kidney biopsies.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Female; Fluorescent Antibody Technique; HIV Infections; Humans; Immunohistochemistry; Kidney; Male; Microscopy, Electron; Middle Aged; Nephritis, Interstitial; Oligopeptides; Organophosphonates; Pyridines; Retrospective Studies; Tenofovir | 2007 |
Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates.
Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Catalysis; Cell Line; Dose-Response Relationship, Drug; Endogenous Retroviruses; HIV-1; Humans; Kidney; Molecular Sequence Data; Organophosphonates; Polymerase Chain Reaction; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Stavudine; Swine; Swine, Miniature; Tenofovir; Virus Replication; Zidovudine | 2007 |
Optimal duration of therapy in HBV-related cirrhosis.
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Health Planning Guidelines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2007 |
Recommendations for the treatment of chronic hepatitis B infection in children.
Topics: Adenine; Antiviral Agents; Child; Child, Preschool; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Male; Organophosphonates; Pakistan; Practice Guidelines as Topic | 2007 |
Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptase.
Topics: Adenine; Antiviral Agents; Cell Line, Transformed; Codon; Deoxycytidine; Didanosine; Dideoxynucleosides; Drug Resistance, Viral; Emtricitabine; HeLa Cells; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Organophosphonates; Point Mutation; Reassortant Viruses; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Relevance of a combined UV and single mass spectrometry detection for the determination of tenofovir in human plasma by HPLC in therapeutic drug monitoring.
Topics: Adenine; Calibration; Drug Monitoring; HIV Infections; Humans; Mass Spectrometry; Organophosphonates; Reference Standards; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tenofovir | 2007 |
Chronic renal failure among HIV-1-infected patients.
Topics: Adenine; Adult; Aged; Anti-Retroviral Agents; CD4 Lymphocyte Count; Creatinine; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Hypertension; Indinavir; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Atazanavir-associated nephrolithiasis: cases from the US Food and Drug Administration's Adverse Event Reporting System.
Topics: Adenine; Adult; Adverse Drug Reaction Reporting Systems; Atazanavir Sulfate; Drug Therapy, Combination; Female; HIV Infections; HIV Protease Inhibitors; Hospitalization; Humans; Male; Middle Aged; Nephrolithiasis; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; United States | 2007 |
Molecular assessment of the potential for renal drug interactions between tenofovir and HIV protease inhibitors.
Topics: Adenine; Animals; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Dogs; Dose-Response Relationship, Drug; Drug Interactions; HIV Protease Inhibitors; Humans; Inhibitory Concentration 50; Kidney; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Transfection | 2007 |
Reversibility of cirrhosis in HIV/HBV coinfection.
Topics: Adenine; Adult; Alanine Transaminase; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; DNA, Viral; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Liver Cirrhosis; Male; Organophosphonates; Platelet Count; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load; Virus Replication | 2007 |
Adefovir dipivoxil monotherapy and combination therapy with lamivudine for the treatment of chronic hepatitis B in an Asian population.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Asian People; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Hong Kong; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome; Viral Load | 2007 |
Does tenofovir influence efavirenz pharmacokinetics?
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Cross-Sectional Studies; Cyclopropanes; Cytochrome P-450 CYP2B6; Drug Interactions; Drug Therapy, Combination; Female; Genotype; HIV Infections; Humans; Liver; Longitudinal Studies; Male; Middle Aged; Models, Biological; Organophosphonates; Oxidoreductases, N-Demethylating; Phenotype; Reverse Transcriptase Inhibitors; Switzerland; Tenofovir | 2007 |
Improvements in parameters of end-stage liver disease in patients with HIV/HBV-related cirrhosis treated with tenofovir.
Topics: Adenine; CD4 Lymphocyte Count; DNA, Viral; Follow-Up Studies; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; HIV Infections; Humans; Liver Cirrhosis; Liver Failure; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Severity of Illness Index; Tenofovir; Time Factors; Treatment Outcome; Viral Load | 2007 |
Evolution of viral load and changes of polymerase and precore/core promoter sequences in lamivudine-resistant hepatitis B virus during adefovir therapy.
Topics: Adenine; Adult; Antiviral Agents; Base Sequence; DNA Mutational Analysis; DNA Primers; DNA, Viral; Drug Resistance, Viral; Evolution, Molecular; Female; Gene Products, pol; Genes, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Promoter Regions, Genetic; Viral Core Proteins; Viremia | 2007 |
Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir.
Topics: Adenine; Adenosine Triphosphate; Anti-HIV Agents; Base Sequence; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Microbial Sensitivity Tests; Molecular Sequence Data; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2007 |
Assessment of adverse events associated with antiretroviral regimens for postexposure prophylaxis for occupational and nonoccupational exposures to prevent transmission of human immunodeficiency virus.
Topics: Adenine; Adult; Anti-HIV Agents; Chemoprevention; Drug Combinations; Female; HIV Infections; Humans; Lamivudine; Logistic Models; Male; Middle Aged; New York; Occupational Exposure; Occupational Health Services; Organophosphonates; Patient Compliance; Public Health Administration; Retrospective Studies; Risk Factors; Sex Factors; Student Health Services; Tenofovir; Universities; Zidovudine | 2007 |
Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors | 2007 |
The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years.
Topics: Adenine; Adult; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Anti-Retroviral Agents; Antiviral Agents; Body Weight; CD4 Lymphocyte Count; Creatinine; Drug Therapy, Combination; Female; HIV Infections; Humans; Kidney; Kidney Diseases; Male; Organophosphonates; Product Surveillance, Postmarketing; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir | 2007 |
Transmission of multidrug-resistant HIV-1: 5 years of immunological and virological survey.
Topics: Adenine; Anti-Retroviral Agents; CD4 Lymphocyte Count; Drug Resistance, Multiple, Viral; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Lopinavir; Mutation; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir; Viral Load | 2007 |
Cutaneous reactions with tenofovir disoproxil fumarate: a report of nine cases.
Topics: Adenine; Adult; Drug Eruptions; Drug Therapy, Combination; Exanthema; Female; HIV Infections; HIV Protease Inhibitors; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Skin; Tenofovir | 2007 |
Pharmacokinetics of once-daily tenofovir, emtricitabine, ritonavir and fosamprenavir in HIV-infected subjects.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Carbamates; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Organophosphates; Organophosphonates; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Sulfonamides; Tenofovir; Treatment Outcome | 2007 |
Development of a sensitive and specific liquid chromatography/mass spectrometry method for the determination of tenofovir in human plasma.
Topics: Adenine; Calibration; Chromatography, Liquid; Drug Stability; Freezing; Humans; Molecular Structure; Organophosphonates; Reference Standards; Reproducibility of Results; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Temperature; Tenofovir; Time Factors; Zalcitabine | 2007 |
pH-dependent interactions of indinavir and lipids in nanoparticles and their ability to entrap a solute.
Topics: Adenine; Drug Delivery Systems; Fluoresceins; Hydrogen-Ion Concentration; Indinavir; Lipids; Membrane Fluidity; Nanoparticles; Organophosphonates; Solubility; Tenofovir | 2008 |
[Recent advances in the treatment of the hepatitis HBV-related. Effectiveness and tolerability of adefovir dipivoxil].
Topics: Adenine; Antiviral Agents; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Treatment Outcome | 2007 |
Comparative analysis of xanafide cytotoxicity in breast cancer cell lines.
Topics: Adenine; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Humans; Imides; Isoquinolines; Mice; Mice, Nude; Naphthalimides; Organophosphonates | 2007 |
Viral genotype and baseline load predict the response to adefovir treatment in lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Gene Dosage; Genotype; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Retrospective Studies; Reverse Transcriptase Inhibitors; Sex Factors; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2007 |
Does pre-treatment with lamivudine prime for adefovir resistance of hepatitis B virus infection?
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2007 |
Emergence of hepatitis B virus quasispecies with lower susceptibility to nucleos(t)ide analogues during lamivudine treatment.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Nucleosides; Nucleotides; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Viremia | 2007 |
Tenofovir renal safety in HIV-infected patients: results from the SCOLTA Project.
Topics: Adenine; Adult; Age Factors; Anti-HIV Agents; Cohort Studies; Comorbidity; Female; Follow-Up Studies; HIV Infections; Humans; Incidence; Italy; Kidney Diseases; Male; Middle Aged; Organophosphonates; Prevalence; Prospective Studies; Risk Factors; Severity of Illness Index; Sex Factors; Tenofovir | 2008 |
In vitro selection and characterization of human immunodeficiency virus type 1 resistant to Zidovudine and tenofovir.
Topics: Adenine; Amino Acid Sequence; Cell Line, Transformed; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Sequence Homology, Amino Acid; Tenofovir; Zidovudine | 2007 |
Renal function in Tenofovir-exposed and Tenofovir-unexposed patients receiving highly active antiretroviral therapy in the HIV Outpatient Study.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Creatinine; HIV Infections; Humans; Organophosphonates; Outpatients; Tenofovir | 2007 |
Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase.
Topics: Adenine; DNA Repair; Drug Resistance, Multiple, Viral; Genetic Engineering; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Models, Molecular; Mutation; Organophosphonates; Protein Binding; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine | 2007 |
Amprenavir and didanosine are associated with declining kidney function among patients receiving tenofovir.
Topics: Adenine; Adult; Age Factors; Analysis of Variance; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Body Weight; Carbamates; Creatinine; Didanosine; Drug Interactions; Female; Furans; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Kidney; Linear Models; Male; Middle Aged; Organophosphonates; Sulfonamides; Tenofovir; Time Factors | 2007 |
Causes and consequences of hypokalemia in patients on tenofovir disoproxil fumarate.
Topics: Adenine; Adult; Cause of Death; Drug Monitoring; Drug Synergism; Fanconi Syndrome; Female; Guideline Adherence; HIV Infections; HIV-1; Humans; Hypokalemia; Male; Middle Aged; Organophosphonates; Product Surveillance, Postmarketing; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Effect of tenofovir on renal glomerular and tubular function.
Topics: Adenine; Anti-Retroviral Agents; Case-Control Studies; Cross-Sectional Studies; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Kidney Diseases; Kidney Glomerulus; Kidney Tubules; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Porphyria cutanea tarda in an HIV-1-infected patient after the initiation of tipranavir/ritonavir: case report.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Middle Aged; Organophosphonates; Porphyria Cutanea Tarda; Pyridines; Pyrones; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides; Tenofovir | 2007 |
In vitro susceptibility of adefovir-associated hepatitis B virus polymerase mutations to other antiviral agents.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Multiple, Viral; Hepatitis B; Hepatitis B virus; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Transfection; Viral Proteins | 2007 |
[An economic evaluation of different treatments for HBeAg-positive chronic hepatitis B in China].
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Quality-Adjusted Life Years; Treatment Outcome | 2007 |
Acute renal failure in HIV patients.
Topics: Acute Kidney Injury; Adenine; AIDS-Associated Nephropathy; Antiretroviral Therapy, Highly Active; Clinical Trials as Topic; Humans; Kidney; Organophosphonates; Tenofovir | 2007 |
HPV oral infection. Case report of an HIV-positive Nigerian sex worker.
Topics: Adenine; Adult; Alphapapillomavirus; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Female; HIV Infections; Humans; Italy; Lamivudine; Lopinavir; Mouth Mucosa; Nigeria; Organophosphonates; Papillomavirus Infections; Pyrimidinones; Ritonavir; Sex Work; Stomatitis; Tenofovir; Treatment Refusal; Zidovudine | 2007 |
Pre- and post-treatment predictors of the early achievement of HBeAg loss in lamivudine-resistant patients receiving adefovir therapy.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Predictive Value of Tests; Reverse Transcriptase Inhibitors | 2007 |
In vitro suppression of K65R reverse transcriptase-mediated tenofovir- and adefovir-5'-diphosphate resistance conferred by the boranophosphonate derivatives.
Topics: Adenine; Adenosine Triphosphate; Boron Compounds; Catalysis; DNA-Directed RNA Polymerases; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Kinetics; Magnetic Resonance Spectroscopy; Mutation; Organophosphonates; Plasmids; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells.
Topics: Adenine; Deoxycytidine; DNA Replication; DNA, Mitochondrial; Hepatocytes; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
A second chance for microbicides.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Infective Agents; Clinical Trials as Topic; Female; HIV Infections; Humans; Organophosphonates; Prevalence; Rural Health Services; Sex Work; South Africa; Tenofovir; Vaginal Creams, Foams, and Jellies | 2007 |
Bone disease and pathologic fractures in a patient with tenofovir-induced Fanconi syndrome.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Diseases; Fanconi Syndrome; Female; Femoral Neck Fractures; HIV Infections; Humans; Middle Aged; Organophosphonates; Tenofovir | 2007 |
Editorial comment: Fanconi syndrome and tenofovir--understanding proximal tubular function.
Topics: Adenine; Adult; Anti-HIV Agents; Child; Fanconi Syndrome; Humans; Kidney Tubules, Proximal; Organophosphonates; Tenofovir | 2007 |
Evaluation of hexadecyloxypropyl-9-R-[2-(Phosphonomethoxy)propyl]- adenine, CMX157, as a potential treatment for human immunodeficiency virus type 1 and hepatitis B virus infections.
Topics: Adenine; Animals; Anti-HIV Agents; Antiviral Agents; Cell Line; Female; Hepatitis B; Hepatitis B virus; HIV Core Protein p24; HIV Infections; HIV-1; Humans; Magnetic Resonance Spectroscopy; Male; Organophosphonates; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity.
Topics: Acetamides; Adenine; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Camptothecin; Cell Line, Tumor; Cellular Senescence; Deoxycytidine; Drug Screening Assays, Antitumor; Erythrocyte Count; Female; Gemcitabine; Humans; Imides; Irinotecan; Isoquinolines; Leukocyte Count; Maximum Tolerated Dose; Mice; Naphthalimides; Neoplasm Transplantation; Organophosphonates; Platelet Count; Structure-Activity Relationship; Topoisomerase I Inhibitors; Urea | 2007 |
Early onset of tenofovir-induced renal failure: case report and review of the literature.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Antiretroviral Therapy, Highly Active; Biopsy; HIV Infections; Humans; Liver; Male; Organophosphonates; Renal Insufficiency; Tenofovir; Time Factors; Treatment Outcome | 2007 |
Adverse events experienced by three children taking tenofovir and didanosine in combination.
Topics: Adenine; Anti-HIV Agents; Child; Child, Preschool; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Male; Organophosphonates; Tenofovir; Viral Load | 2007 |
Effects of human immunodeficiency virus protease inhibitors on the intestinal absorption of tenofovir disoproxil fumarate in vitro.
Topics: Adenine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Interactions; Epithelium; HIV Protease Inhibitors; Humans; Hydrolysis; Indicators and Reagents; Intestinal Absorption; Mass Spectrometry; Organophosphonates; Subcellular Fractions; Tenofovir | 2007 |
Pradefovir, a liver-targeted prodrug of adefovir against HBV infection.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Delivery Systems; Hepatitis B, Chronic; Humans; Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Structure-Activity Relationship | 2007 |
Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T-cell restoration during antiretroviral therapy.
Topics: Adenine; Animals; Anti-Retroviral Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; DNA, Viral; Emtricitabine; Flow Cytometry; Immunologic Memory; Lymphoid Tissue; Macaca mulatta; Organophosphonates; Polymerase Chain Reaction; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocyte Subsets; Tenofovir; Viral Load; Virus Replication; Zalcitabine | 2007 |
Direct stringency comparison of two macaque models (single-high vs. repeat-low) for mucosal HIV transmission using an identical anti-HIV chemoprophylaxis intervention.
Topics: Adenine; Administration, Rectal; Animals; Anti-HIV Agents; Antibodies, Viral; Chemoprevention; Disease Models, Animal; Macaca mulatta; Male; Organophosphonates; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2007 |
[Hypophosphatemia and multiple fractures in patient with human immunodeficiency virus infection treated with tenofovir].
Topics: Adenine; Adult; Fractures, Bone; HIV Infections; Humans; Hypophosphatemia; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
[A case of chronic hepatitis B with primary adefovir resistance].
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Organophosphonates | 2007 |
Hepatitis B virus and HIV coinfection: results of a survey on treatment practices and recommendations for therapy.
Topics: Adenine; Adult; Anti-Retroviral Agents; Antiviral Agents; Drug Therapy, Combination; Female; Guideline Adherence; Health Care Surveys; Hepatitis B Vaccines; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Practice Guidelines as Topic; Practice Patterns, Physicians'; Tenofovir; United States | 2007 |
Combination adefovir-lamivudine prevents emergence of adefovir resistance in lamivudine-resistant hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2007 |
Pooled analysis of amino acid changes in the HBV polymerase in patients from four major adefovir dipivoxil clinical trials.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Clinical Trials as Topic; DNA Mutational Analysis; Drug Resistance, Viral; Female; Gene Products, pol; Hepatitis B; Hepatitis B virus; Humans; Male; Mutation; Organophosphonates; Polymorphism, Genetic | 2007 |
Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2007 |
Adefovir for lamivudine resistant HBV: more than meets the eye.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Mutation; Organophosphonates | 2007 |
Predictors and kinetics of occult hepatitis B virus infection in HIV-infected persons.
Topics: Adenine; Adult; Alanine Transaminase; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; Carrier State; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cohort Studies; DNA, Viral; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; HIV Infections; HIV-1; Humans; Lamivudine; London; Male; Organophosphonates; Prevalence; Tenofovir | 2007 |
DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions.
Topics: Adenine; Animals; Antiviral Agents; Chlorocebus aethiops; Cidofovir; Cytosine; Disease Models, Animal; DNA-Directed DNA Polymerase; Drug Resistance, Multiple, Viral; Enzyme Inhibitors; Exodeoxyribonucleases; Foscarnet; Genotype; Herpes Simplex; Herpesvirus 1, Human; Humans; Mice; Models, Molecular; Mutation; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Phenotype; Protein Binding; Protein Conformation; Vero Cells; Viral Proteins; Virulence | 2007 |
A novel mutation pattern emerging during lamivudine treatment shows cross-resistance to adefovir dipivoxil treatment.
Topics: Adenine; Adult; Arabinofuranosyluracil; Base Sequence; Cell Line, Tumor; Cloning, Molecular; Deoxycytidine; DNA Mutational Analysis; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Viral; Emtricitabine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Molecular Sequence Data; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Time Factors; Transfection; Treatment Outcome; Viral Load; Virus Replication | 2007 |
Lopinavir-ritonavir dramatically affects the pharmacokinetics of irinotecan in HIV patients with Kaposi's sarcoma.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Antiretroviral Therapy, Highly Active; Area Under Curve; Camptothecin; Drug Therapy, Combination; HIV Infections; Humans; Irinotecan; Lamivudine; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrimidinones; Ritonavir; Sarcoma, Kaposi; Tenofovir; White People | 2008 |
Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates.
Topics: Adenine; Adult; Analysis of Variance; Anti-Retroviral Agents; Cells, Cultured; Chemokine CCL3; Chemokine CCL4; Chemokine CCL5; Chemokines; Female; Humans; Interferon-gamma; Leukocytes, Mononuclear; Male; Middle Aged; Organophosphonates; Stereoisomerism; Structure-Activity Relationship | 2007 |
Antiretroviral drug exposure in the female genital tract: implications for oral pre- and post-exposure prophylaxis.
Topics: Adenine; Administration, Oral; Adult; Alkynes; Anti-Retroviral Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Genitalia, Female; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Lopinavir; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Tenofovir; Zidovudine | 2007 |
Variations in reverse transcriptase and RNase H domain mutations in human immunodeficiency virus type 1 clinical isolates are associated with divergent phenotypic resistance to zidovudine.
Topics: Adenine; Amino Acid Sequence; Deoxycytidine; Drug Resistance, Multiple, Viral; Genetic Variation; HIV Infections; HIV-1; Humans; Molecular Sequence Data; Mutation; Organophosphonates; Phenotype; Ribonuclease H; RNA-Directed DNA Polymerase; Sequence Homology, Amino Acid; Tenofovir; Zidovudine | 2007 |
Room temperature ionic liquid as matrix medium for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography.
Topics: Adenine; Analytic Sample Preparation Methods; Borates; Chromatography, Gas; Drug Contamination; Imidazoles; Ionic Liquids; Organophosphonates; Pharmaceutical Preparations; Reproducibility of Results; Sensitivity and Specificity; Solvents; Temperature; Ultrasonics; Volatilization | 2007 |
Diverse approaches useful for microbicide trials.
Topics: Adenine; Animals; Anti-HIV Agents; Anti-Infective Agents; Bias; Clinical Trials as Topic; Female; HIV Infections; Humans; Male; Organophosphonates; South Africa; Tenofovir | 2007 |
Prophylaxis of hepatitis B recurrence in post-liver transplantation patients with lamivudine-resistant YMDD mutant.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Hepatitis B; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Mutation; Organophosphonates; Recurrence | 2007 |
Amonafide, a topoisomerase II inhibitor, is unaffected by P-glycoprotein-mediated efflux.
Topics: Adenine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Multiple; Enzyme Inhibitors; Humans; Imides; Isoquinolines; Mice; Naphthalimides; Organophosphonates; Topoisomerase II Inhibitors | 2008 |
Determination of plasma tenofovir concentrations using a conventional LC-MS method.
Topics: Adenine; Adrenergic beta-Antagonists; Anti-HIV Agents; Atenolol; Calibration; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Mass Spectrometry; Organophosphonates; Reference Standards; Reproducibility of Results; Tenofovir | 2007 |
Effect of oral treatment with hexadecyloxypropyl-[(S)-9-(3-hydroxy-2- phosphonylmethoxypropyl)adenine] [(S)-HPMPA] or octadecyloxyethyl-(S)-HPMPA on cowpox or vaccinia virus infections in mice.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cowpox; Kidney; Liver; Lung; Mice; Molecular Structure; Organophosphonates; Spleen; Vaccinia virus | 2007 |
Redetection of HBV lamivudine-resistant mutations in a patient under entecavir therapy, who had been treated sequentially with nucleos(t)ide analogues.
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors | 2007 |
Novel drug resistance pattern associated with the mutations K70G and M184V in human immunodeficiency virus type 1 reverse transcriptase.
Topics: Adenine; Amino Acid Substitution; Deoxycytidine; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Emtricitabine; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Molecular Sequence Data; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Zidovudine | 2007 |
[New German and American guidelines for therapy of hepatitis B. Discrepancies and similarities].
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Biopsy; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Germany; Guanine; Hepatitis B; Humans; Lamivudine; Liver; Liver Cirrhosis; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pyrimidinones; Telbivudine; Thymidine; United States | 2007 |
Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Cells, Cultured; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Male; Mice; Microscopy, Electron, Transmission; Nucleosides; Organophosphonates; Organophosphorus Compounds; Orthopoxvirus; Swiss 3T3 Cells; Virus Replication | 2007 |
Is phosphatemia the best tool to monitor renal tenofovir toxicity?
Topics: Adenine; Biomarkers; Creatinine; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Kidney Tubules; Organophosphonates; Phosphates; Tenofovir | 2007 |
[Effect of initial virologic response to adefovir on the development of resistance to adefovir in lamivudine-resistant chronic hepatitis B].
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Retrospective Studies | 2007 |
Semen quality and drug concentrations in seminal plasma of patients using a didanosine or didanosine plus tenofovir containing antiretroviral regimen.
Topics: Adenine; Adult; Anti-HIV Agents; Cross-Sectional Studies; Didanosine; Drug Therapy, Combination; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Semen; Sperm Motility; Spermatozoa; Tenofovir | 2007 |
Increased beta-2 microglobulinuria in human immunodeficiency virus-1-infected children and adolescents treated with tenofovir.
Topics: Adenine; Adolescent; Adult; beta 2-Microglobulin; Child; Child, Preschool; Cross-Sectional Studies; Female; HIV Infections; Humans; Male; Organophosphonates; Proteinuria; Reverse Transcriptase Inhibitors; Tenofovir; Urine | 2007 |
Development of a novel mouse model to evaluate drug candidates against hepatitis B virus.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Drug Evaluation, Preclinical; Hepatitis B; Hepatitis B virus; Lamivudine; Mice; Mice, Nude; Organophosphonates; Reproducibility of Results; Tenofovir | 2007 |
Summaries for patients. Antiviral therapy for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine; Viral Load | 2007 |
Evolution of primary and compensatory lamivudine resistance mutations in chronic hepatitis B virus-infected patients during long-term lamivudine treatment, assessed by a line probe assay.
Topics: Adenine; Amino Acid Substitution; Drug Resistance, Viral; Evolution, Molecular; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation, Missense; Nucleic Acid Hybridization; Organophosphonates; Sequence Analysis, DNA; Time Factors | 2007 |
[Recent therapies for hepatitis B (discussion)].
Topics: Adenine; Antiviral Agents; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Organophosphonates | 2007 |
CD4+ T-cell count increase in HIV-1-infected patients with suppressed viral load within 1 year after start of antiretroviral therapy.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Tenofovir; Time Factors; Viral Load | 2007 |
The cost-effectiveness of long-term antiviral therapy in the management of HBeAg-positive and HBeAg-negative chronic hepatitis B in Singapore.
Topics: Adenine; Antiviral Agents; Asian People; Cost-Benefit Analysis; Drug Costs; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Markov Chains; Models, Economic; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Singapore | 2007 |
Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear cells.
Topics: Adenine; Anti-HIV Agents; Cytidine Triphosphate; Deoxyguanine Nucleotides; Dideoxynucleosides; Dideoxynucleotides; HIV Infections; Humans; Lamivudine; Leukocytes, Mononuclear; Organophosphonates; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tenofovir | 2008 |
Successful treatment of an entecavir-resistant hepatitis B virus variant.
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Multiple, Viral; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Mutation; Organophosphonates; Viral Load | 2007 |
Female-initiated prevention strategies key to tackling HIV.
Topics: Adenine; Africa South of the Sahara; Anti-HIV Agents; Condoms, Female; Diaphragm; Female; HIV Infections; Humans; Organophosphonates; Primary Prevention; Reverse Transcriptase Inhibitors; Rwanda; Tenofovir; Women | 2007 |
In vivo study of the effect of antiviral acyclic nucleotide phosphonate (R)-9-[2-(phosphonomethoxy)propyl]adenine (PMPA, tenofovir) and its prodrug tenofovir disoproxil fumarate on rat microsomal cytochrome P450.
Topics: Adenine; Animals; Antiviral Agents; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochromes; Down-Regulation; Female; Injections, Intraperitoneal; Liver; Microsomes, Liver; Organophosphonates; Prodrugs; Protein Denaturation; Rats; Rats, Inbred Lew; RNA, Messenger; Tenofovir | 2008 |
Tenofovir resistance among HIV-infected patients failing a fixed-dose combination of stavudine, lamivudine, and nevirapine in a resource-limited setting.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Mutation; Nevirapine; Organophosphonates; Stavudine; Tenofovir; Thailand; Treatment Outcome | 2007 |
[Adefovir in reactivation of chemotherapy-induced hepatitis B in an anti-Hbc-positive patient].
Topics: Adenine; Aged; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bleomycin; Dacarbazine; Doxorubicin; Fatal Outcome; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lymphoma, Non-Hodgkin; Organophosphonates; Prion Diseases; Vinblastine; Virus Activation | 2007 |
Prophylaxsis against recurrance of hepatitis B virus after liver transplantation: a retrospective analysis spanning 20 years.
Topics: Adenine; Adult; Antiviral Agents; Dose-Response Relationship, Drug; Female; Hepatitis B; Hepatitis B e Antigens; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Retrospective Studies; Secondary Prevention; Virginia | 2008 |
Hepatitis B: explosion of new knowledge.
Topics: Adenine; Antiviral Agents; Disease Progression; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immune Tolerance; Lamivudine; Organophosphonates | 2007 |
Long-term therapy with adefovir dipivoxil in hepatitis B e antigen-negative patients developing resistance to lamivudine.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Statistics, Nonparametric | 2008 |
Hepatitis B virus containing the I233V mutation in the polymerase reverse-transcriptase domain remains sensitive to inhibition by adefovir.
Topics: Adenine; Adult; Aged; Antiviral Agents; Clinical Trials, Phase III as Topic; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Randomized Controlled Trials as Topic; RNA-Directed DNA Polymerase | 2007 |
Mitochondrial toxicity of tenofovir, emtricitabine and abacavir alone and in combination with additional nucleoside reverse transcriptase inhibitors.
Topics: Adenine; Anti-HIV Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Dideoxynucleosides; DNA, Mitochondrial; Emtricitabine; Humans; Lactic Acid; Lipid Metabolism; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Area Under Curve; Atazanavir Sulfate; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Male; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir | 2008 |
Selection of L74V mutation in reverse transcriptase of HIV-1 subtype D by a tenofovir DF-lamivudine based regimen.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; Female; Follow-Up Studies; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2007 |
Reply to Crane et al., 'Amprenavir and didanosine are associated with declining kidney function among patients receiving tenofovir'.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Male; Organophosphonates; Retrospective Studies; Tenofovir | 2007 |
Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates.
Topics: Adenine; Anti-HIV Agents; Combinatorial Chemistry Techniques; Drug Design; HIV; Molecular Structure; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tenofovir | 2007 |
Adefovir dipivoxil therapy in liver transplant recipients for recurrence of hepatitis B virus infection despite lamivudine plus hepatitis B immunoglobulin prophylaxis.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence; Serologic Tests | 2007 |
Congenital pyelectasis in children born from mothers on tenofovir containing therapy during pregnancy: report of two cases.
Topics: Adenine; Adult; Anti-HIV Agents; Female; HIV Infections; Humans; Infant, Newborn; Italy; Kidney; Male; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir | 2007 |
Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors.
Topics: Adenine; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Proliferation; Drug Interactions; Drug Therapy, Combination; HIV Infections; Humans; Nucleosides; Nucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Up-Regulation | 2008 |
Synthesis and anticancer activities of 6-amino amonafide derivatives.
Topics: Acetylation; Adenine; Animals; Antineoplastic Agents; Arylamine N-Acetyltransferase; Cell Line, Tumor; Cell Nucleolus; Cell Proliferation; DNA; DNA Damage; Humans; Imides; Intercalating Agents; Isoquinolines; Magnetic Resonance Spectroscopy; Naphthalimides; Neoplasm Invasiveness; Organophosphonates; Structure-Activity Relationship; Subcellular Fractions; Topoisomerase I Inhibitors | 2008 |
Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strand.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; DNA Primers; DNA-Directed DNA Polymerase; DNA, Viral; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Templates, Genetic; Vaccinia virus; Virus Replication | 2008 |
Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.
Topics: Adenine; Anti-HIV Agents; Diphosphates; Guanosine; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
Topics: Adenine; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cell Line; Dogs; Drug Design; Drug Resistance, Viral; Guanosine; HIV-1; Humans; Leukocytes, Mononuclear; Macrophages; Male; Microbial Sensitivity Tests; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors | 2008 |
The microbicide tenofovir does not inhibit nucleic acid amplification tests for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in urine samples.
Topics: Adenine; Anti-Infective Agents; Chlamydia Infections; Chlamydia trachomatis; Female; Gonorrhea; Humans; Male; Neisseria gonorrhoeae; Nucleic Acid Amplification Techniques; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Urine | 2008 |
Inhibition of HIV-1 replication in macrophages by red blood cell-mediated delivery of a heterodinucleotide of lamivudine and tenofovir.
Topics: Adenine; Anti-HIV Agents; Drug Delivery Systems; Drug Design; Erythrocytes; HIV-1; Humans; In Vitro Techniques; Lamivudine; Macrophages; Organophosphonates; Tenofovir; Virus Replication | 2007 |
Acute renal failure after initiation of tenofovir disoproxil fumarate.
Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2007 |
Minor emtricitabine intolerance in treatment-stable patients switched from tenofovir/lamivudine to a fixed-dose combination of tenofovir/emtricitabine (Truvada).
Topics: Adenine; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Humans; Lamivudine; Organophosphonates; Organophosphorus Compounds; Sleep Initiation and Maintenance Disorders; Tenofovir | 2008 |
Tenofovir nephrotoxicity: focusing research questions and putting them into clinical context.
Topics: Adenine; HIV Infections; Humans; Kidney Diseases; Kidney Tubules; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Pradefovir: a prodrug that targets adefovir to the liver for the treatment of hepatitis B.
Topics: Adenine; Administration, Oral; Animals; Biological Availability; Dogs; Hepatocytes; In Vitro Techniques; Liver; Male; Microsomes, Liver; Organophosphonates; Organophosphorus Compounds; Prodrugs; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution | 2008 |
Tenofovir DF plus lamivudine or emtricitabine for nonoccupational postexposure prophylaxis (NPEP) in a Boston Community Health Center.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Boston; Clinical Trials, Phase IV as Topic; Community Health Centers; Deoxycytidine; Disease Transmission, Infectious; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2008 |
SAR of carbon-linked, 2-substituted purines: synthesis and characterization of AP23451 as a novel bone-targeted inhibitor of Src tyrosine kinase with in vivo anti-resorptive activity.
Topics: Adenine; Bone Resorption; Crystallography, X-Ray; Drug Delivery Systems; Enzyme Inhibitors; Humans; Hypercalcemia; Inhibitory Concentration 50; Molecular Structure; Organophosphonates; Osteoporosis; Parathyroid Hormone; Phosphinic Acids; Purines; src-Family Kinases; Structure-Activity Relationship | 2008 |
Tenofovir-based rescue therapy for advanced liver disease in 6 patients coinfected with HIV and hepatitis B virus and receiving lamivudine.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; HIV; HIV Infections; Homosexuality, Male; Humans; Lamivudine; Liver Diseases; Male; Organophosphonates; Tenofovir; Transaminases; Viral Load | 2008 |
Switching patients with lamivudine resistant chronic hepatitis B virus from tenofovir to adefovir results in less potent HBV-DNA suppression.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Viral Load; Virus Replication | 2008 |
Potency of tenofovir in chronic hepatitis B: mono or combination therapy?
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2008 |
[Protocol for the treatment of chronic viral hepatitis].
Topics: Adenine; Algorithms; Antiviral Agents; Clinical Protocols; Hepacivirus; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin | 2008 |
Can the new humanized mouse model give HIV research a boost.
Topics: Adenine; Administration, Intravaginal; Animals; Deoxycytidine; Disease Models, Animal; Disease Susceptibility; Drug Evaluation, Preclinical; Emtricitabine; Female; Hematopoietic Stem Cell Transplantation; HIV Infections; HIV-1; Humans; Liver Transplantation; Macaca mulatta; Mice; Mice, Inbred NOD; Mice, Inbred Strains; Mice, SCID; Organophosphonates; Radiation Chimera; Species Specificity; Tenofovir; Thymus Gland; Transplantation, Heterologous | 2008 |
Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice.
Topics: Adenine; Administration, Intravaginal; Animals; Anti-HIV Agents; Deoxycytidine; Disease Models, Animal; Drug Evaluation, Preclinical; Emtricitabine; Female; Fetal Tissue Transplantation; Genitalia, Female; Hematopoietic Stem Cell Transplantation; HIV Infections; HIV-1; Humans; Immunity, Mucosal; Liver Transplantation; Mice; Mice, Inbred Strains; Mice, SCID; Organophosphonates; Radiation Chimera; Species Specificity; Tenofovir; Thymus Gland; Transplantation, Heterologous | 2008 |
Evaluation of initial virological response to adefovir and development of adefovir-resistant mutations in patients with chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation, Missense; Organophosphonates; Treatment Outcome; Viral Load | 2008 |
[Kinetics of HBV mutants conferring adefovir resistance (rtn236t) and a method to detect them rapidly].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length | 2008 |
Tenofovir use is associated with a reduction in calculated glomerular filtration rates in the Swiss HIV Cohort Study.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Kidney; Male; Organophosphonates; Switzerland; Tenofovir | 2007 |
Transdermal and dermal delivery of adefovir: effects of pH and permeation enhancers.
Topics: Adenine; Administration, Cutaneous; Antiviral Agents; Chromatography, High Pressure Liquid; Drug Delivery Systems; Excipients; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Organophosphonates; Permeability; Skin Absorption; Solvents | 2008 |
Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir.
Topics: Adenine; Animals; Deoxycytidine; Drug Administration Schedule; Emtricitabine; Macaca; Macaca mulatta; Organophosphonates; Rectum; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir | 2008 |
Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system.
Topics: Adenine; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Anti-HIV Agents; Child; Fanconi Syndrome; Female; HIV Infections; Humans; Incidence; Male; Middle Aged; Organophosphonates; Registries; Retrospective Studies; Risk Assessment; Survival Analysis; Tenofovir; United States; United States Food and Drug Administration | 2008 |
Lamivudine-resistant chronic hepatitis B: an observational study on adefovir in monotherapy or in combination with lamivudine.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Prospective Studies; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome; Viral Load | 2008 |
Anti-BK virus activity of nucleoside analogs.
Topics: Adenine; BK Virus; Esters; Fatty Acids; Humans; Microbial Sensitivity Tests; Nucleosides; Organophosphonates; Virus Replication | 2008 |
Adaptation of antiretroviral therapy in human immunodeficiency virus infection with central nervous system involvement.
Topics: Adenine; Adult; AIDS Dementia Complex; Alkynes; Anti-HIV Agents; Anticonvulsants; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cerebrospinal Fluid; Cyclopropanes; Didanosine; HIV-1; Humans; Indinavir; Lamivudine; Male; Nelfinavir; Nevirapine; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Seizures; Stavudine; Tenofovir; Viral Load; Virus Replication; Zidovudine | 2008 |
6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4.
Topics: Adenine; Animals; Base Sequence; DNA Primers; Green Fluorescent Proteins; Humans; Mercaptopurine; Multidrug Resistance-Associated Proteins; Mutagenesis, Site-Directed; Mutation, Missense; Organophosphonates; Recombinant Fusion Proteins; Xenopus laevis | 2008 |
Tenofovir plus lamivudine as rescue therapy for adefovir-resistant chronic hepatitis B in hepatitis B e antigen-positive patients with liver cirrhosis.
Topics: Adenine; Adult; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2008 |
Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure.
Topics: Adenine; Amino Acid Sequence; DNA, Viral; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Molecular Sequence Data; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Treatment Failure | 2008 |
Effect of oral treatment with (S)-HPMPA, HDP-(S)-HPMPA or ODE-(S)-HPMPA on replication of murine cytomegalovirus (MCMV) or human cytomegalovirus (HCMV) in animal models.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Cidofovir; Cytomegalovirus; Cytomegalovirus Infections; Cytosine; Herpesviridae Infections; Liver; Mice; Mice, Inbred BALB C; Mice, SCID; Muromegalovirus; Organophosphonates; Survival Analysis | 2008 |
European CHMP issues positive opinion for Atripla.
Topics: Adenine; Adult; Anti-HIV Agents; Canada; Deoxycytidine; Drug Approval; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Europe; HIV Infections; HIV-1; Humans; Organophosphonates; Oxazines; United States | 2007 |
Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding.
Topics: Adenine; Antiviral Agents; Aphidicolin; Binding Sites; Cell Division; DNA Polymerase I; Enzyme Inhibitors; Humans; Keratinocytes; Ligands; Models, Biological; Models, Molecular; Organophosphonates; Protein Conformation; Reverse Transcriptase Inhibitors | 2008 |
Adefovir and lamivudine in combination compared with adefovir monotherapy in HBeAg-negative adults with chronic hepatitis B virus infection and clinical or virologic resistance to lamivudine: a retrospective, multicenter, nonrandomized, open-label study.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multicenter Studies as Topic; Organophosphonates; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load | 2008 |
Cost-effectiveness analysis of emtricitabine/tenofovir versus lamivudine/zidovudine, in combination with efavirenz, in antiretroviral-naive, HIV-1-infected patients.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cost-Benefit Analysis; Cyclopropanes; Decision Trees; Deoxycytidine; Drug Costs; Emtricitabine; Health Care Costs; Health Resources; HIV Infections; HIV-1; Humans; Lamivudine; Models, Economic; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Treatment Outcome; Zidovudine | 2008 |
Urolithiasis under atazanavir boosted and tenofovir therapy: a case report.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; Atazanavir Sulfate; HIV Infections; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Urolithiasis; Viral Load | 2008 |
Decreased bone mineral density with off-label use of tenofovir in children and adolescents infected with human immunodeficiency virus.
Topics: Absorptiometry, Photon; Adenine; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone Density; Child; Female; HIV; HIV Infections; Humans; Male; Organophosphonates; Tenofovir | 2008 |
[Anti-viral therapy of type B chronic hepatitis. 3. Future of anti-viral agents].
Topics: Adenine; Antiviral Agents; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Hepatitis B, Chronic; Humans; Interferons; Nucleic Acid Synthesis Inhibitors; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2008 |
Syncope as a probable side effect to combination antiretroviral therapy initiated during primary HIV-1 infection.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Male; Nevirapine; Organophosphonates; Syncope; Tenofovir | 2008 |
The human multidrug resistance protein 4 (MRP4, ABCC4): functional analysis of a highly polymorphic gene.
Topics: Adenine; Antiviral Agents; Base Sequence; California; Cell Line; Ethnicity; Haplotypes; Humans; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Organophosphonates; Polymorphism, Single Nucleotide; Sequence Alignment; Sequence Analysis, DNA; White People; Zidovudine | 2008 |
[Factors affecting initial virologic response and emergence of resistant mutants after adefovir treatment in lamivudine-resistant chronic hepatitis B patients].
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymorphism, Restriction Fragment Length | 2008 |
Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques.
Topics: Adenine; Animals; Anti-HIV Agents; Antibodies; Antibody Specificity; Antiviral Agents; CD8-Positive T-Lymphocytes; Chemoprevention; Deoxycytidine; Drug Administration Schedule; Drug Evaluation, Preclinical; Emtricitabine; HIV-1; Injections, Intravenous; Injections, Subcutaneous; Lymphocyte Count; Macaca mulatta; Organophosphonates; Reassortant Viruses; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Viral Load; Viremia | 2008 |
Antibody to hepatitis B surface antigen trough levels and half-lives do not differ after intravenous and intramuscular hepatitis B immunoglobulin administration after liver transplantation.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Injections, Intramuscular; Injections, Intravenous; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence | 2008 |
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.
Topics: Adenine; Anti-HIV Agents; Binding Sites; Cidofovir; Cytosine; DNA, Viral; Drug Resistance, Viral; Gene Expression Regulation, Viral; HIV Reverse Transcriptase; Models, Molecular; Molecular Structure; Organophosphonates; Protein Conformation; Tenofovir | 2008 |
Economic evaluation of chronic hepatitis B treatments in Taiwan.
Topics: Adenine; Adult; Antiviral Agents; Cost-Benefit Analysis; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Taiwan; Time Factors | 2008 |
Severe acute pancreatitis related to the use of adefovir in a liver transplant recipient.
Topics: Acute Disease; Adenine; Aged; Antiviral Agents; Hepatitis B; Humans; Liver Transplantation; Male; Organophosphonates; Pancreatitis; Postoperative Complications; Recurrence | 2008 |
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.
Topics: Adenine; Adenosine Triphosphate; Adenylate Kinase; Binding Sites; Boranes; Catalytic Domain; Cloning, Molecular; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Kinetics; Models, Molecular; Nucleotides; Organophosphonates; Phosphorylation; Recombinant Proteins; Tenofovir | 2008 |
Changing patterns in HIV reverse transcriptase resistance mutations after availability of tenofovir.
Topics: Adenine; Anti-HIV Agents; Didanosine; Drug Resistance, Multiple, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Synthesis of cidofovir and (S)-HPMPA ether lipid prodrugs.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Magnetic Resonance Spectroscopy; Organophosphonates; Spectrometry, Mass, Electrospray Ionization | 2007 |
Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases.
Topics: Adenine; Alanine; Anti-HIV Agents; beta-N-Acetylhexosaminidases; Biomarkers; Cathepsin A; Cells, Cultured; Enzyme Activation; Humans; Hydrolysis; Kinetics; Leukocytes, Mononuclear; Lysosomes; Molecular Structure; Organophosphonates; Peptide Hydrolases; Prodrugs; Reverse Transcriptase Inhibitors; Serine Endopeptidases; Subcellular Fractions; Substrate Specificity; Tenofovir | 2008 |
Viral persistence after liver transplantation for hepatitis B virus: a cross-sectional study.
Topics: Adenine; Adult; Aged; Cross-Sectional Studies; DNA, Viral; Female; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates | 2008 |
Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Mutation; Organophosphonates; Risk Factors; Treatment Outcome; Virus Replication | 2008 |
Europe extends Viread indication for chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Clinical Trials, Phase III as Topic; Drug Approval; Europe; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Comparison of the Cobas Ampliprep/Cobas TaqMan HBV Test versus the Cobas Amplicor HBV monitor for HBV-DNA detection and quantification during antiviral therapy.
Topics: Adenine; Antiviral Agents; Automation; DNA, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Polymerase Chain Reaction; Taq Polymerase | 2008 |
Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Female; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Logistic Models; Male; Middle Aged; Organophosphonates; Point Mutation; Tenofovir | 2008 |
FDA grants tentative approval to first generic version of antiretroviral Viread.
Topics: Adenine; Anti-HIV Agents; Drug Approval; Drugs, Generic; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2008 |
European Commission approves Atripla.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Approval; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Emtricitabine; European Union; HIV Infections; Humans; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Does tenofovir increase efavirenz hepatotoxicity?
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Chemical and Drug Induced Liver Injury; Cyclopropanes; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2008 |
Hepatitis B virus genotype A2 harbours an L217R polymorphism which may account for a lower response to adefovir.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Male; Mutation, Missense; Organophosphonates | 2008 |
Test of new vaginal microbicide gel show promise for women.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Administration, Intravaginal; Anti-Infective Agents, Local; Anti-Retroviral Agents; Female; HIV; HIV Seronegativity; Humans; India; Organophosphonates; Safety; Tenofovir; Treatment Outcome; United States; Vaginal Creams, Foams, and Jellies | 2008 |
[Acute renal failure associated with the use of tenofovir combined with atazanavir in patients with HIV infection].
Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; Atazanavir Sulfate; Drug Therapy, Combination; HIV Infections; Humans; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Tenofovir | 2008 |
[Severe hypokalemia and tenofovir].
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Hypokalemia; Male; Middle Aged; Organophosphonates; Severity of Illness Index; Tenofovir | 2008 |
Targeting only reverse transcriptase with zidovudine/lamivudine/abacavir plus tenofovir in HIV-1-infected patients with multidrug-resistant virus: a multicentre pilot study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Thymidine; Viral Load; Zidovudine | 2008 |
[Acute hepatitis B: is antiviral therapy indicated? Two case reports].
Topics: Acute Disease; Adenine; Adult; Algorithms; Antiviral Agents; Bilirubin; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Liver; Middle Aged; Organophosphonates; Prothrombin Time; Transaminases; Treatment Failure; Treatment Outcome | 2008 |
Partial immunological and mitochondrial recovery after reducing didanosine doses in patients on didanosine and tenofovir-based regimens.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Didanosine; Dose-Response Relationship, Drug; Drug Therapy, Combination; HIV Infections; Humans; Male; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Switch from ritonavir-boosted to unboosted atazanavir guided by therapeutic drug monitoring.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Bilirubin; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Retrospective Studies; Ritonavir; Tenofovir | 2008 |
[The predictive value of ALT, HBeAg and HBV DNA levels at baseline and the degree of HBV suppression at week 12 adefovir dipivoxil treatment to the efficacy of it at week 52 in patients with HBeAg-positive chronic hepatitis B].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Predictive Value of Tests; Treatment Outcome; Young Adult | 2008 |
Genetic basis of variation in tenofovir drug susceptibility in HIV-1.
Topics: Adenine; Amino Acid Sequence; Anti-HIV Agents; Drug Resistance, Viral; Genetic Variation; Genotype; HIV Infections; HIV-1; Humans; Lethal Dose 50; Models, Biological; Organophosphonates; Phenotype; Predictive Value of Tests; Tenofovir | 2008 |
Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy.
Topics: Adenine; Amines; Antiviral Agents; Cell Line; Drug Delivery Systems; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Glycerides; Hepatitis B virus; Humans; Nanoparticles; Nanotechnology; Organophosphonates | 2008 |
Cost and cost-effectiveness of switching from stavudine to tenofovir in first-line antiretroviral regimens in South Africa.
Topics: Adenine; Adult; Anti-HIV Agents; Cost-Benefit Analysis; Humans; Models, Biological; Organophosphonates; Quality of Life; South Africa; Stavudine; Tenofovir | 2008 |
Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4.
Topics: Adenine; Antiviral Agents; Biological Transport; Cell Membrane; Down-Regulation; Fluorescent Antibody Technique, Indirect; Green Fluorescent Proteins; HeLa Cells; Humans; Immunoblotting; Immunoprecipitation; Immunosuppressive Agents; Kidney; Mercaptopurine; Multidrug Resistance-Associated Proteins; Organophosphonates; Phosphoproteins; Protein Transport; Recombinant Fusion Proteins; RNA, Small Interfering; Signal Transduction; Sodium-Hydrogen Exchangers; Transfection | 2008 |
Human immunodeficiency virus-induced uveitis: intraocular and plasma human immunodeficiency virus-1 RNA loads.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Aqueous Humor; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Eye Infections, Viral; HIV Antibodies; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Polymerase Chain Reaction; RNA, Viral; Tenofovir; Uveitis, Anterior; Viral Load | 2008 |
Rosiglitazone reverses tenofovir-induced nephrotoxicity.
Topics: Adenine; Animals; Drug-Related Side Effects and Adverse Reactions; Glomerular Filtration Rate; Hypoglycemic Agents; Hypophosphatemia; Hypophosphatemia, Familial; Kidney Diseases; Male; Membrane Transport Proteins; Organophosphonates; Rats; Rats, Wistar; Reverse Transcriptase Inhibitors; Rosiglitazone; Tenofovir; Thiazolidinediones | 2008 |
Replication of clinical hepatitis B virus isolate and its application for selecting antiviral agents for chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Viral; Genetic Vectors; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleic Acid Amplification Techniques; Organophosphonates; Plasmids; Replicon; Transfection; Virus Replication | 2008 |
FDA notifications. FDA's tentative approval for generic Tenofovir.
Topics: Adenine; Drug Approval; Drugs, Generic; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2008 |
Antiviral resistance mutations potentiate hepatitis B virus immune evasion through disruption of its surface antigen a determinant.
Topics: Adenine; Animals; Antibodies, Monoclonal; Antigen-Antibody Reactions; Antiviral Agents; CHO Cells; Cricetinae; Cricetulus; Drug Resistance, Multiple, Viral; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Gene Products, pol; Guanine; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunodominant Epitopes; Lamivudine; Mutagenesis, Site-Directed; Mutation; Organophosphonates; Transfection | 2008 |
Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects.
Topics: Adenine; Age Factors; Animals; Anti-HIV Agents; Disease Models, Animal; Female; HIV Infections; HIV-1; Humans; Macaca mulatta; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Treatment Outcome | 2008 |
[Chronic hepatitis B. Tenofovir--the right choice from the beginning].
Topics: Adenine; Antiviral Agents; Drug Approval; Europe; Hepatitis B, Chronic; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
[Drug approval studies of Viread. As effective in HBeAg positive as also in HBeAg negative patients].
Topics: Adenine; Antiviral Agents; Drug Approval; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Multicenter Studies as Topic; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
[Comparison of antiviral responses to adefovir dipivoxil therapy of genotype B and genotype C HBV infected patients].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2008 |
The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Didanosine; Dideoxynucleosides; Drug Resistance, Multiple, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Organophosphonates; Point Mutation; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Virus Replication | 2008 |
Lack of evidence for an effect of lopinavir/ritonavir on tenofovir renal clearance.
Topics: Adenine; Creatinine; Drug Interactions; Drug Therapy, Combination; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Tubules; Lopinavir; Male; Organophosphonates; Pyrimidinones; Ritonavir; Sensitivity and Specificity; Tenofovir | 2008 |
Continuous single motor unit electromyographic activity in adefovir associated myopathy.
Topics: Adenine; Antiviral Agents; Chronic Disease; Creatine Kinase; Electromyography; Hepatitis B; Humans; Male; Middle Aged; Mitochondria; Mitochondrial Diseases; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscular Diseases; Neuromuscular Junction; Organophosphonates; Withholding Treatment | 2008 |
Selection of an entecavir-resistant mutant despite prolonged hepatitis B virus DNA suppression, in a chronic hepatitis B patient with preexistent lamivudine resistance: successful rescue therapy with tenofovir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Tenofovir; Viral Load | 2008 |
Predictive factors associated with the progression to hepatic failure caused by lamivudine-resistant HBV.
Topics: Adenine; Adult; Antiviral Agents; Bilirubin; Disease Progression; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Failure; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Patient Selection; Predictive Value of Tests; Prognosis; Prothrombin Time; Retrospective Studies; Treatment Outcome | 2008 |
What is the optimum dose of adefovir in the treatment of chronic hepatitis B infection?
Topics: Adenine; Adult; Antiviral Agents; Dose-Response Relationship, Drug; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Treatment Outcome | 2008 |
A new assay based on solid-phase extraction procedure with LC-MS to measure plasmatic concentrations of tenofovir and emtricitabine in HIV infected patients.
Topics: Adenine; Anti-HIV Agents; Calibration; Chromatography, Liquid; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tenofovir | 2008 |
Rapid re-emergence of YMDD mutation of hepatitis B virus with hepatic decompensation after lamivudine retreatment.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Male; Middle Aged; Mutation; Organophosphonates; Time Factors | 2008 |
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species.
Topics: Adenine; Administration, Cutaneous; Animals; Antiviral Agents; Caproates; Chemistry, Pharmaceutical; Diffusion Chambers, Culture; Dimethylamines; Dodecanol; Female; Humans; Hydrogen-Ion Concentration; Kinetics; Methylamines; Organophosphonates; Permeability; Pharmaceutical Vehicles; Skin; Skin Absorption; Species Specificity; Swine | 2008 |
Antiviral effects of lamivudine, emtricitabine, adefovir dipivoxil, and tenofovir disoproxil fumarate administered orally alone and in combination to woodchucks with chronic woodchuck hepatitis virus infection.
Topics: Adenine; Animals; Antigens, Viral; Antiviral Agents; Deoxycytidine; Disease Models, Animal; DNA, Viral; Drug Therapy, Combination; Emtricitabine; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Marmota; Organophosphonates; RNA, Viral; Rodent Diseases; Tenofovir; Virus Replication | 2008 |
Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel.
Topics: Adenine; Animals; Anti-Infective Agents, Local; Antibody Formation; Cross-Priming; Gels; HeLa Cells; HIV-1; Humans; Interferon-gamma; Macaca; Organophosphonates; Rectum; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir; Treatment Outcome; Virus Replication | 2008 |
Can a topical microbicide prevent rectal HIV transmission?
Topics: Adenine; Animals; Anti-Infective Agents, Local; HIV Infections; Macaca; Organophosphonates; Tenofovir | 2008 |
Tenofovir-associated decline in renal function.
Topics: Adenine; Adult; Anti-HIV Agents; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Kidney Diseases; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Entecavir therapy for adefovir-resistant hepatitis B virus infection in kidney and liver allograft recipients.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Kidney Transplantation; Liver Function Tests; Liver Transplantation; Male; Middle Aged; Organophosphonates; Pilot Projects; Prothrombin Time | 2008 |
Antiretroviral rounds. Is that "one pill" treatment enough?
Topics: Adenine; CD4 Lymphocyte Count; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; Humans; Middle Aged; Organophosphonates; Oxazines; Viral Load | 2008 |
Drug-susceptible HIV-1 infection despite intermittent fixed-dose combination tenofovir/emtricitabine as prophylaxis is associated with low-level viremia, delayed seroconversion, and an attenuated clinical course.
Topics: Adenine; Adult; Amino Acid Sequence; Anti-HIV Agents; CD4 Lymphocyte Count; Chemoprevention; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV Seropositivity; HIV-1; HLA Antigens; Humans; Intestinal Mucosa; Male; Microbial Sensitivity Tests; Molecular Sequence Data; Organophosphonates; Phylogeny; Receptors, CCR5; Sequence Alignment; Tenofovir; Time Factors; Viral Load; Viremia | 2008 |
CD4 count improvement following tenofovir to abacavir switch in a patient with persistent lymphopenia despite an undetectable viral load.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Female; Humans; Lamivudine; Middle Aged; Organophosphonates; Tenofovir | 2008 |
Effect of tenofovir subtraction on HIV plasma viraemia, CD4+ T-cell count and resistance in a patient with baseline K65R and M184V mutations.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Outcome; Viremia | 2008 |
Thermodynamic studies of interactions of calf spleen PNP with acyclic phosphonate inhibitors.
Topics: Adenine; Animals; Enzyme Inhibitors; Guanine; Organophosphonates; Organophosphorus Compounds; Purine-Nucleoside Phosphorylase; Spleen; Thermodynamics | 2008 |
Combination antiretroviral therapy with tenofovir, emtricitabine or lamivudine, and nevirapine.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Lamivudine; Nevirapine; Organophosphonates; Tenofovir | 2008 |
Population pharmacokinetics of tenofovir in AIDS patients.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Drug Interactions; Female; Humans; Male; Middle Aged; Models, Biological; Organophosphonates; Prospective Studies; Tenofovir | 2008 |
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous determination of tenofovir and emtricitabine in human plasma and its application to a bioequivalence study.
Topics: Adenine; Calibration; Chromatography, Liquid; Deoxycytidine; Drug Combinations; Drug Stability; Emtricitabine; Humans; Organophosphonates; Practice Guidelines as Topic; Quality Control; Reference Standards; Reproducibility of Results; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Tablets; Tandem Mass Spectrometry; Tenofovir; Therapeutic Equivalency; Time Factors | 2008 |
The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cost-Benefit Analysis; Dideoxynucleosides; Drug Costs; Drug Hypersensitivity; Female; Genetic Testing; Health Care Costs; HIV Infections; HLA-B Antigens; Humans; Male; Middle Aged; Models, Biological; Organophosphonates; Pharmacogenetics; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Tenofovir; Treatment Outcome | 2008 |
Adefovir dipivoxil is effective for the treatment of cirrhotic patients with lamivudine failure.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Cohort Studies; Drug Resistance; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2009 |
Does the presence of adefovir-resistant variants lead to failure of tenofovir monotherapy?
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Genetic Variation; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure | 2008 |
[A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus].
Topics: Absorptiometry, Photon; Adenine; Adult; Antiviral Agents; Bone Density; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Hypophosphatemia; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Tomography, X-Ray Computed | 2008 |
[Construction of full-length genome HBV plasmid with adefovir dipivoxil drug-resistance gene in RT domain of polymerase].
Topics: Adenine; Drug Resistance, Viral; Genome, Viral; Hepatitis B virus; Organophosphonates; Plasmids; Viral Proteins | 2008 |
[YMDD motif variants detected by Inno-Lipa HBV DR assay in chronic hepatitis B patients during lamivudine therapy].
Topics: Adenine; Amino Acid Motifs; Anti-HIV Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 2008 |
Weight evolution in HIV-1 infected women in Rwanda after stavudine substitution due to lipoatrophy: comparison of zidovudine with tenofovir/abacavir.
Topics: Adenine; Adult; Anti-HIV Agents; Body Weight; Dideoxynucleosides; Drug Therapy, Combination; Female; HIV-1; HIV-Associated Lipodystrophy Syndrome; Humans; Organophosphonates; Rwanda; Stavudine; Tenofovir; Treatment Outcome; Weight Loss; Zidovudine | 2009 |
Are hepatitis B e antigen (HBeAg)-positive chronic hepatitis B and HBeAg-negative chronic hepatitis B distinct diseases?
Topics: Adenine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates | 2008 |
Sustained hepatitis B e antigen seroconversion in patients with chronic hepatitis B after adefovir dipivoxil treatment: analysis of precore and basal core promoter mutants.
Topics: Adenine; Adult; Alanine Transaminase; Asian People; DNA Mutational Analysis; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Mutation; Organophosphonates; Promoter Regions, Genetic; White People | 2008 |
Effectiveness and safety of simplification from tenofovir-lamivudine (TDF-3TC) to tenofovir-emtricitabine (TDF-FTC) co-formulation (Truvada) in virologically suppressed HIV-infected patients on HAART.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Central Nervous System; Cohort Studies; Creatinine; Deoxycytidine; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; HIV-1; Humans; Kidney; Lamivudine; Male; Metabolic Clearance Rate; Middle Aged; Organophosphonates; Organophosphorus Compounds; Retrospective Studies; Risk Factors; RNA, Viral; Tenofovir; Viral Load | 2009 |
Structural insights into the catalytic mechanism of the bacterial class B phosphatase AphA belonging to the DDDD superfamily of phosphohydrolases.
Topics: Acid Phosphatase; Adenine; Aluminum Compounds; Aniline Compounds; Beryllium; Catalysis; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Escherichia coli; Escherichia coli Proteins; Fluorides; Hydrogen Bonding; Multigene Family; Organophosphonates; Organophosphorus Compounds; Protein Structure, Secondary; Substrate Specificity | 2008 |
Disinhibition and risk compensation: scope, definitions, and perspective.
Topics: Adenine; Anti-HIV Agents; Chemoprevention; Clinical Trials as Topic; Counseling; Female; HIV Infections; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Reduction Behavior; Safe Sex; Sex Work; Sexual Behavior; Sexually Transmitted Diseases; Tenofovir | 2008 |
Simultaneous quantification of a non-nucleoside reverse transcriptase inhibitor efavirenz, a nucleoside reverse transcriptase inhibitor emtricitabine and a nucleotide reverse transcriptase inhibitor tenofovir in plasma by liquid chromatography positive io
Topics: Adenine; Alkynes; Animals; Benzoxazines; Chromatography, High Pressure Liquid; Cyclopropanes; Deoxycytidine; Emtricitabine; Humans; Organophosphonates; Rats; Reverse Transcriptase Inhibitors; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tenofovir | 2009 |
Serum HBsAg changes in HBeAg positive chronic hepatitis B patients with continuous viral load reductions during treatment with adefovir or peg-interferon-alpha-2a.
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Viral Load | 2009 |
Adverse effects of tenofovir use in HIV-infected pregnant women and their infants.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Organophosphonates; Pregnancy; Retrospective Studies; Tenofovir | 2008 |
Hepatitis B virus genotype-associated variability in antiviral response to adefovir dipivoxil therapy in Chinese Han population.
Topics: Adenine; Adult; Alanine Transaminase; Antibodies, Viral; Antiviral Agents; Asian People; DNA, Viral; Ethnicity; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates | 2008 |
Regression of HIV-related diffuse large B-cell lymphoma in response to antiviral therapy alone.
Topics: Adenine; Anti-HIV Agents; Antifungal Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Fluconazole; HIV Infections; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Organophosphonates; Oxazines; Positron-Emission Tomography; Radiography; Trimethoprim, Sulfamethoxazole Drug Combination | 2008 |
Adefovir combined with hepatitis C virus treatment may prevent hepatitis B reactivation after hepatitis C virus eradication in hepatitis B and C virus carriers.
Topics: Adenine; Adult; Antiviral Agents; Carrier State; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Male; Organophosphonates; Virus Activation | 2008 |
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.
Topics: Adenine; Animals; Cell Line; Cell Survival; CHO Cells; Cidofovir; Cricetinae; Cricetulus; Cytosine; Guanosine; HIV Reverse Transcriptase; Humans; In Vitro Techniques; Kidney; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Low trough levels of tipranavir in a combination antiretroviral therapy of tipranavir/ritonavir and tenofovir require therapeutic drug monitoring.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Drug Interactions; Drug Monitoring; Enfuvirtide; HIV Envelope Protein gp41; HIV Infections; Humans; Organophosphonates; Peptide Fragments; Pyridines; Pyrones; Retrospective Studies; Ritonavir; Sulfonamides; Tenofovir | 2008 |
Core promoter mutant HBV non-responding to adefovir after viral breakthrough on lamivudine: rapid virologic response to tenofovir plus lamivudine in a cirrhotic patient.
Topics: Adenine; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Mutation; Organophosphonates; Promoter Regions, Genetic; Tenofovir | 2008 |
Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination.
Topics: Adenine; Administration, Cutaneous; Alanine; Animals; Caproates; Chemistry, Pharmaceutical; Dimethylamines; Dodecanol; Drug Carriers; Drug Compounding; Drug Stability; Electric Impedance; Esterases; Halogenation; Hydrocortisone; Hydrolysis; Indomethacin; Isomerism; Methylamines; Molecular Structure; Organophosphonates; Skin; Skin Absorption; Structure-Activity Relationship; Swine; Theophylline; Time Factors | 2009 |
Sensitivity and accuracy of an updated line probe assay (HBV DR v.3) in detecting mutations associated with hepatitis B antiviral resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA Probes; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Sensitivity and Specificity | 2009 |
[First line therapy. Tenofovir DF/emtricitabine--the potent backbone].
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Organophosphonates; Tenofovir; Viral Load | 2008 |
[Complete HAART in a single pill. New milestone for improving compliance].
Topics: Acquired Immunodeficiency Syndrome; Adenine; Antiretroviral Therapy, Highly Active; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Oxazines; Viral Load | 2008 |
[HIV therapy and adherence].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Darunavir; Deoxycytidine; Drug Combinations; Drug Resistance, Viral; Drug Therapy, Combination; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Oxazines; Patient Compliance; Prognosis; Pyridines; Pyrones; Sulfonamides | 2008 |
[One pill--all HAART. Complete divergent HAART in a single tablet per day].
Topics: Adenine; Antiretroviral Therapy, Highly Active; Clinical Trials as Topic; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Oxazines; Patient Compliance | 2008 |
Two-year data released on Viread for chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Clinical Trials, Phase III as Topic; Hepatitis B, Chronic; Humans; Multicenter Studies as Topic; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2008 |
Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Viral; Gene Products, pol; Hepatitis B virus; Humans; Microbial Sensitivity Tests; Mutation, Missense; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2009 |
Sensitivity of phenotypic susceptibility analyses for nonthymidine nucleoside analogues conferred by K65R or M184V in mixtures with wild-type HIV-1.
Topics: Adenine; Anti-HIV Agents; Didanosine; Dideoxynucleosides; Drug Therapy, Combination; Genetic Predisposition to Disease; Genotype; HIV Infections; HIV-1; Humans; Lamivudine; Organophosphonates; Phenotype; Plasmids; Tenofovir; Viral Load | 2009 |
The rise and fall of K65R in a Portuguese HIV-1 Drug Resistance database, despite continuously increasing use of tenofovir.
Topics: Adenine; Anti-HIV Agents; Bayes Theorem; Data Interpretation, Statistical; Databases, Nucleic Acid; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation; Organophosphonates; Portugal; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Assessment of selective real-time PCR for quantitation of lamivudine and adefovir hepatitis B virus-resistant strains and comparison with direct sequencing and line probe assays.
Topics: Adenine; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Humans; Lamivudine; Mutation; Organophosphonates; Plasmids; Polymerase Chain Reaction; Sensitivity and Specificity | 2009 |
[Protocol for the antiviral therapy of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2008 |
96-week CASTLE data show similar efficacy results.
Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Lopinavir; Multicenter Studies as Topic; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome; Viral Load | 2008 |
Chronic hepatitis B--new goals, new treatment.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Viral Load | 2008 |
Synthesis of new amonafide analogues via coupling reaction and their cytotoxic evaluation and DNA-binding studies.
Topics: Adenine; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Humans; Naphthalenes; Naphthalimides; Organophosphonates; Structure-Activity Relationship | 2009 |
Combination of tenofovir and emtricitabine plus efavirenz: in vitro modulation of ABC transporter and intracellular drug accumulation.
Topics: Adenine; Alkynes; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Benzoxazines; Cells, Cultured; Cyclopropanes; Deoxycytidine; Drug Interactions; Drug Therapy, Combination; Emtricitabine; Fluoresceins; Fluorescent Dyes; Humans; Leukocytes, Mononuclear; Organophosphonates; RNA, Messenger; Tenofovir; Time Factors | 2009 |
[Development of clevudine resistance after switching from lamivudine in a patient with chronic hepatitis B].
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Arabinofuranosyluracil; Base Sequence; DNA, Viral; Drug Resistance, Multiple, Viral; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Reverse Transcriptase Inhibitors | 2008 |
[A case of acute renal failure involving high amounts of tenofovir after HAART start].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Kidney Failure, Chronic; Male; Middle Aged; Organophosphonates; Tenofovir | 2008 |
Minority quasispecies of drug-resistant HIV-1 that lead to early therapy failure in treatment-naive and -adherent patients.
Topics: Adenine; Alkynes; Alleles; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Medication Adherence; Mutation, Missense; Nevirapine; Organophosphonates; Plasma; Polymerase Chain Reaction; Selection, Genetic; Tenofovir; Treatment Failure | 2009 |
Glomerular filtration rates in HIV-infected patients treated with and without tenofovir: a prospective, observational study.
Topics: Adenine; Adult; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; RNA, Viral; Tenofovir; Viral Load | 2009 |
Urinary cystatin C can improve the renal safety follow-up of tenofovir-treated patients.
Topics: Adenine; Anti-HIV Agents; Biomarkers; Creatinine; Cystatin C; Fanconi Syndrome; HIV Infections; Humans; Hypophosphatemia; Organophosphonates; Retrospective Studies; Sensitivity and Specificity; Tenofovir | 2009 |
Molecular analysis of an HBsAg-negative hepatitis B virus mutant selected in a tenofovir-treated HIV-hepatitis B virus co-infected patient.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Gene Products, pol; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Male; Mutation; Organophosphonates; Tenofovir; Virus Replication | 2009 |
Population pharmacokinetics of emtricitabine in human immunodeficiency virus type 1-infected pregnant women and their neonates.
Topics: Adenine; Anti-HIV Agents; Area Under Curve; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Female; Half-Life; HIV Infections; HIV-1; Humans; Infant, Newborn; Maternal-Fetal Exchange; Organophosphonates; Population Groups; Pregnancy; Pregnancy Complications, Infectious; Prenatal Exposure Delayed Effects; Tenofovir | 2009 |
Lamivudine monoprophylaxis and adefovir salvage for liver transplantation in chronic hepatitis B: a seven-year follow-up study.
Topics: Adenine; Adult; Carcinoma, Hepatocellular; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2009 |
HIV-1 infection of human penile explant tissue and protection by candidate microbicides.
Topics: Adenine; Antiviral Agents; CD4-Positive T-Lymphocytes; Cytokines; Foreskin; HIV Infections; HIV-1; Humans; Langerhans Cells; Male; Naphthalenesulfonates; Organophosphonates; Penis; Polymers; Tenofovir; Tissue Culture Techniques; Urethra; Virus Replication | 2009 |
[The efficacy of adefovir dipivoxil monotherapy and the incidence of genotypic resistance to adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B infection].
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Sequence Analysis, DNA | 2008 |
Gilead AIDS pill effective in study with weekends off.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Humans; Organophosphonates; Oxazines | 2008 |
Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA; Viral Load | 2009 |
Association of lamivudine-resistant mutational patterns with the antiviral effect of adefovir in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA; Serum; Viral Load | 2009 |
Comment on: High rate of early virological failure with the once-daily tenofovir/lamivudine/nevirapine combination in naive HIV-1-infected patients.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Lamivudine; Nevirapine; Organophosphonates; Tenofovir; Treatment Failure; Viral Load | 2009 |
Adefovir dipivoxil-induced acute tubular necrosis and Fanconi syndrome in a renal transplant patient.
Topics: Acute Kidney Injury; Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Kidney Transplantation; Male; Middle Aged; Organophosphonates | 2009 |
Application of UV-spectrophotometric methods for estimation of tenofovir disoproxil fumarate in tablets.
Topics: Adenine; Chemistry, Pharmaceutical; Guidelines as Topic; Organophosphonates; Reproducibility of Results; Reverse Transcriptase Inhibitors; Spectrophotometry, Ultraviolet; Tablets; Technology, Pharmaceutical; Tenofovir | 2009 |
On-treatment monitoring of adefovir therapy in chronic hepatitis B: virologic response can be assessed at 24 weeks.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Treatment Outcome; Viral Load | 2009 |
Hepatitis B virus viral load and treatment decision.
Topics: Adenine; Algorithms; Antiviral Agents; Decision Making; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis C, Chronic; Humans; Male; Organophosphonates; Patient Selection; RNA, Viral; Tenofovir; Viral Load | 2009 |
Prolonged use of tenofovir in HIV/hepatitis B virus (HBV)-coinfected individuals does not lead to HBV polymerase mutations and is associated with persistence of lamivudine HBV polymerase mutations.
Topics: Adenine; Adult; Aged; Antiretroviral Therapy, Highly Active; Antiviral Agents; Cross-Sectional Studies; Drug Resistance, Viral; Female; Gene Products, pol; Genotype; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Retrospective Studies; Tenofovir; Viral Load; Viremia | 2009 |
Early development of clevudine resistance during clevudine therapy in a patient with chronic hepatitis B who received prior lamivudine therapy.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA | 2009 |
HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness.
Topics: Adenine; Adult; Anti-HIV Agents; Chemoprevention; Computer Simulation; Cost-Benefit Analysis; Deoxycytidine; Emtricitabine; HIV Infections; Homosexuality; Humans; Male; Organophosphonates; Risk Assessment; Tenofovir; United States | 2009 |
The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs.
Topics: Adenine; Anti-HIV Agents; Delavirdine; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Lamivudine; Microbial Sensitivity Tests; Mutation, Missense; Nevirapine; Organophosphonates; Protein Binding; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response.
Topics: Adenine; Antiviral Agents; Biomarkers; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Models, Molecular; Organophosphonates; Predictive Value of Tests; Retrospective Studies; RNA-Directed DNA Polymerase | 2008 |
Tenofovir use is associated with an increase in serum alkaline phosphatase in the Swiss HIV Cohort Study.
Topics: Adenine; Adult; Alkaline Phosphatase; Anti-HIV Agents; Cohort Studies; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Switzerland; Tenofovir | 2008 |
[Introduction. Tenofovir].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
[Conclusions. Tenofovir].
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Viral; HIV; HIV Infections; HIV Reverse Transcriptase; Humans; Kidney Diseases; Liver Diseases; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Emergence of adefovir-resistant mutants after reversion to YMDD wild-type in lamivudine-resistant patients receiving adefovir monotherapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymorphism, Restriction Fragment Length; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Treatment Outcome; Viral Load | 2009 |
A preemptive strike against HIV.
Topics: Adenine; Animals; Clinical Trials as Topic; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Gene induction for the treatment of methylmalonic aciduria.
Topics: Adenine; Cisplatin; Drug Evaluation, Preclinical; Gene Expression Regulation; Green Fluorescent Proteins; HeLa Cells; Humans; Metabolism, Inborn Errors; Methylmalonyl-CoA Mutase; Organophosphonates; RNA, Messenger; Zidovudine | 2009 |
Renal side effects of adefovir in hepatitis B virus-(HBV) positive kidney allograft recipients.
Topics: Acid-Base Equilibrium; Adenine; Aged; Antiviral Agents; Cohort Studies; Dose-Response Relationship, Drug; Drug Resistance, Viral; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2009 |
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin | 2008 |
Long-term outcome of tenofovir disoproxil fumarate use against hepatitis B in an HIV-coinfected cohort.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B; Hepatitis B Antigens; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Treatment Outcome; Virus Replication | 2009 |
Effects of the K65R and K65R/M184V reverse transcriptase mutations in subtype C HIV on enzyme function and drug resistance.
Topics: Adenine; DNA Primers; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Kinetics; Mutation, Missense; Organophosphonates; Reverse Transcription; RNA, Viral; Tenofovir | 2009 |
Hepatitis B virus mutations potentially conferring adefovir/tenofovir resistance in treatment-naive patients.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Genetic Variation; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Proteins | 2009 |
A short course of add-on adefovir dipivoxil treatment in lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Salvage Therapy; Sequence Analysis, DNA; Treatment Outcome; Viral Load | 2009 |
Spectrum of chronic kidney disease in HIV-infected patients.
Topics: Adenine; Adult; Age Factors; AIDS-Associated Nephropathy; Analysis of Variance; Anti-HIV Agents; Female; Glomerular Filtration Rate; HIV-1; Humans; Indinavir; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Prevalence; Tenofovir; United Kingdom | 2009 |
Study shows people can safely switch to Atripla.
Topics: Adenine; CD4 Lymphocyte Count; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Oxazines | 2008 |
Virological response and hepatocarcinogenesis in lamivudine-resistant hepatitis B virus genotype C patients treated with lamivudine plus adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Japan; Lamivudine; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2008 |
Entecavir shows limited efficacy in HBeAg-positive hepatitis B patients with a partial virologic response to adefovir therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; RNA, Viral; Treatment Outcome; Viral Load; Young Adult | 2009 |
Partial virological response to nucleos(t)ide analogues in naïve patients with chronic hepatitis B: From guidelines to field practice.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Nucleosides; Nucleotides; Organophosphonates; Tenofovir | 2009 |
[New molecules in the treatment of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir | 2009 |
[Atazanavir-induced nephrolithiasis].
Topics: Adenine; Adult; Alkynes; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Dideoxynucleosides; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis D, Chronic; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; Lamivudine; Lopinavir; Male; Nephrolithiasis; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Stavudine; Tenofovir | 2009 |
Reverse transcriptase inhibitors as potential colorectal microbicides.
Topics: Adenine; Anilides; Anti-HIV Agents; Anti-Infective Agents, Local; Colon; Drug Resistance, Viral; Furans; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Organophosphonates; Pyrimidines; Rectum; Reverse Transcriptase Inhibitors; Tenofovir; Thioamides; Tissue Culture Techniques; Virus Replication | 2009 |
Kidney tubular abnormalities in the absence of impaired glomerular function in HIV patients treated with tenofovir.
Topics: Adenine; Adult; Age Factors; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Creatinine; Epidemiologic Methods; Fanconi Syndrome; Female; HIV Infections; Humans; Kidney Function Tests; Kidney Glomerulus; Kidney Tubules; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
The rtA194T polymerase mutation impacts viral replication and susceptibility to tenofovir in hepatitis B e antigen-positive and hepatitis B e antigen-negative hepatitis B virus strains.
Topics: Adenine; Anti-HIV Agents; Cell Line, Tumor; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Mutation; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Viral Proteins; Virus Replication | 2009 |
Bone pain due to fractures revealing osteomalacia related to tenofovir-induced proximal renal tubular dysfunction in a human immunodeficiency virus-infected patient.
Topics: Adenine; Bone Density Conservation Agents; Fanconi Syndrome; Female; Fractures, Bone; HIV Infections; Humans; Middle Aged; Organophosphonates; Osteomalacia; Pain; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Highly active antiretroviral therapy-associated ptosis in patients with human immunodeficiency virus.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Blepharoptosis; Carbamates; Didanosine; Dideoxynucleosides; Drug Therapy, Combination; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Lamivudine; Male; Middle Aged; Oculomotor Muscles; Organophosphates; Organophosphonates; Sulfonamides; Tenofovir | 2009 |
Tenofovir renal toxicity targets mitochondria of renal proximal tubules.
Topics: Adenine; AIDS-Associated Nephropathy; Animals; Anti-HIV Agents; Didanosine; DNA, Mitochondrial; Female; HIV-1; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microdissection; Mitochondria; Organophosphonates; Tenofovir; Urothelium | 2009 |
The octadecyloxyethyl ester of (S)-9-[3-hydroxy-2-(phosphonomethoxy) propyl]adenine is a potent and selective inhibitor of hepatitis C virus replication in genotype 1A, 1B, and 2A replicons.
Topics: Adenine; Antiviral Agents; Esters; Genotype; Hepacivirus; Organophosphonates; Plasmids; Replicon; Structure-Activity Relationship; Virus Replication | 2009 |
Successful treatment of refractory Behçet's disease with the TNF-alpha blocker infliximab.
Topics: Adenine; Adult; Anti-Inflammatory Agents; Antibodies, Monoclonal; Antiviral Agents; Behcet Syndrome; Hepatitis B; HLA-B Antigens; Humans; Infliximab; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Tumor Necrosis Factor-alpha; Viral Load | 2009 |
Ultra-deep pyrosequencing of hepatitis B virus quasispecies from nucleoside and nucleotide reverse-transcriptase inhibitor (NRTI)-treated patients and NRTI-naive patients.
Topics: Adenine; Antiviral Agents; Base Sequence; DNA Primers; DNA, Viral; Drug Resistance, Viral; Genetic Variation; Genotype; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Mutation; Organophosphonates; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 2009 |
Mitochondrial function, morphology and metabolic parameters improve after switching from stavudine to a tenofovir-containing regimen.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenine; Adipose Tissue; Adult; Anti-HIV Agents; Body Fat Distribution; CD4 Lymphocyte Count; Deoxyguanosine; F2-Isoprostanes; Glutathione; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Lamivudine; Lopinavir; Male; Mitochondria; Organophosphonates; Pyrimidinones; Ritonavir; Stavudine; Tenofovir; Treatment Outcome; Viral Load | 2009 |
Hepatitis B virus with the rtL80V/I mutation is associated with a poor response to adefovir dipivoxil therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Female; Gene Products, pol; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Recovery of Function; Viral Load; Young Adult | 2009 |
Decision analysis model for hepatitis B prophylaxis one year after liver transplantation.
Topics: Adenine; Administration, Oral; Antiviral Agents; Cost Savings; Cost-Benefit Analysis; Decision Support Techniques; Drug Costs; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Health Care Costs; Hepatitis B, Chronic; Humans; Immunoglobulins; Injections, Intramuscular; Lamivudine; Liver Transplantation; Markov Chains; Models, Economic; Organophosphonates; Retrospective Studies; Salvage Therapy; Secondary Prevention; Tenofovir; Time Factors; Treatment Failure; Treatment Outcome | 2009 |
Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases.
Topics: Adenine; Adult; Anti-HIV Agents; Diabetes Insipidus; Didanosine; Drug Therapy, Combination; Fanconi Syndrome; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Editorial comment: tenofovir nephrotoxicity--the disconnect between clinical trials and real-world practice.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Diabetes Insipidus; Didanosine; Drug Therapy, Combination; Fanconi Syndrome; HIV Infections; Humans; Kidney Function Tests; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir | 2009 |
Spondyloarthropathy and chronic B hepatitis. Effect of anti-TNF therapy.
Topics: Adenine; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Antiviral Agents; Drug Therapy, Combination; Etanercept; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Immunoglobulin G; Infliximab; Lamivudine; Male; Methotrexate; Organophosphonates; Receptors, Tumor Necrosis Factor; Spondylarthropathies; Treatment Outcome; Tumor Necrosis Factor-alpha; Viral Load; Virus Activation | 2009 |
[Analysis of the cost-effectiveness of antiviral therapies in chronic hepatitis B patients in Korea].
Topics: Adenine; Antiviral Agents; Cohort Studies; Cost-Benefit Analysis; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Korea; Lamivudine; Models, Statistical; Organophosphonates; Quality of Life; Severity of Illness Index | 2009 |
[Virologic response to adefovir dipivoxil monotherapy is not durable in HBeAg-positive, lamivudine-resistant chronic hepatitis B patients].
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Recurrence; Retrospective Studies; Risk Factors | 2009 |
Gilead is going strong.
Topics: Adenine; Anti-HIV Agents; California; Commerce; Drug Combinations; Drug Industry; HIV Infections; Humans; Organophosphonates; Tenofovir | 2009 |
FDA approves three generics.
Topics: Adenine; Anti-HIV Agents; Drug Approval; Drugs, Generic; HIV Infections; Humans; Lamivudine; Lopinavir; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; United States; United States Food and Drug Administration | 2009 |
Progressive renal tubular dysfunction associated with long-term use of tenofovir DF.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Drug Therapy, Combination; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Kidney Diseases; Kidney Tubules, Proximal; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Urinalysis; Young Adult | 2009 |
Anti-hepatitis B virus activity in vitro of combinations of tenofovir with nucleoside/nucleotide analogues.
Topics: Adenine; Antiviral Agents; Cell Line; Cell Survival; Deoxycytidine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Nucleotides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2009 |
Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Viral Load | 2009 |
Alkoxyalkyl esters of 9-(s)-(3-hydroxy-2-phosphonomethoxypropyl) adenine are potent and selective inhibitors of hepatitis B virus (HBV) replication in vitro and in HBV transgenic mice in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Drug Resistance, Viral; Esters; Female; Hepatitis B virus; Humans; Lamivudine; Male; Mice; Mice, Transgenic; Organophosphonates; Virus Replication | 2009 |
Predictors of kidney tubular dysfunction in HIV-infected patients treated with tenofovir: a pharmacogenetic study.
Topics: Adenine; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Female; Gene Frequency; HIV Infections; Homozygote; Humans; Kidney Tubules; Male; Molecular Sequence Data; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Independent; Organophosphonates; Polymorphism, Genetic; Renal Insufficiency; Tenofovir | 2009 |
Rationing antiretroviral therapy in Africa--treating too few, too late.
Topics: Adenine; Africa; Anti-Retroviral Agents; CD4 Lymphocyte Count; Developing Countries; Drug Administration Schedule; Health Care Rationing; HIV Infections; Humans; Organophosphonates; Stavudine; Tenofovir; Viral Load | 2009 |
Atazanavir-related renal insufficiency without concurrent tenofovir.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Tenofovir | 2009 |
Peginterferon alfa-2a and ribavirin in Latino and non-Latino whites with hepatitis C.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C, Chronic; Hispanic or Latino; Humans; Interferon alpha-2; Interferon-alpha; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Viral Load; White People | 2009 |
[Renal tuberculosis and human immunodeficiency virus infection].
Topics: Acute Kidney Injury; Adenine; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antitubercular Agents; Fatal Outcome; Humans; Kidney Diseases; Male; Middle Aged; Multiple Organ Failure; Organophosphonates; Pneumocystis carinii; Pneumonia, Pneumocystis; Recurrence; Renal Dialysis; Tenofovir; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculosis, Renal | 2009 |
Substituting tenofovir for stavudine in resource-limited settings: there are challenges ahead.
Topics: Adenine; Anti-HIV Agents; Developing Countries; Drug Therapy, Combination; HIV Infections; Humans; Organophosphonates; Stavudine; Tenofovir; Treatment Failure | 2009 |
Initiation of antiretroviral therapy 48 hours after infection with simian immunodeficiency virus potently suppresses acute-phase viremia and blocks the massive loss of memory CD4+ T cells but fails to prevent disease.
Topics: Adenine; Amino Acid Sequence; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cells, Cultured; Disease Models, Animal; Drug Administration Schedule; HIV Antibodies; HIV Infections; Humans; Injections; Macaca mulatta; Molecular Sequence Data; Organophosphonates; Sequence Alignment; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Viremia; Virus Replication | 2009 |
Generic Truvada approved.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Approval; Drug Combinations; Drugs, Generic; Emtricitabine; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2009 |
Emergency transplantation for acute reactivation of chronic hepatitis B with high viral load: role of antiviral therapy.
Topics: Adenine; Blood Chemical Analysis; DNA, Viral; Hepatitis B; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Secondary Prevention; Tenofovir; Ultrasonography; Viral Load | 2009 |
Stop codon read-through of a methylmalonic aciduria mutation.
Topics: Adenine; Chromosomes, Artificial, Bacterial; Cisplatin; Codon, Terminator; Genes, Reporter; Gentamicins; HeLa Cells; Humans; Metabolism, Inborn Errors; Methylmalonyl-CoA Mutase; Mutation, Missense; Organophosphonates; RNA, Messenger; Zidovudine | 2009 |
Can antiviral therapy for chronic hepatitis B enhance the progression to hepatocellular carcinoma?
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Disease Progression; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Neoplasms; Organophosphonates | 2009 |
Clinical usefulness of sequential hepatitis B virus DNA measurement (the roadmap concept) during adefovir treatment in lamivudine-resistant patients.
Topics: Adenine; Adult; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B Antibodies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; Treatment Outcome | 2009 |
Mutations in the thumb-connection and RNase H domain of HIV type-1 reverse transcriptase of antiretroviral treatment-experienced patients.
Topics: Adenine; Alkynes; Amino Acid Substitution; Benzoxazines; Cyclopropanes; Drug Resistance, Multiple, Viral; Genetic Variation; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Protein Structure, Tertiary; Reverse Transcriptase Inhibitors; Ribonuclease H, Human Immunodeficiency Virus; Stavudine; Tenofovir | 2009 |
Prolonged exposure to tenofovir monotherapy 1 month after treatment discontinuation because of tenofovir-related renal failure.
Topics: Adenine; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis C, Chronic; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Withholding Treatment | 2009 |
Current trends in chronic hepatitis B management: results of a questionnaire.
Topics: Adenine; Adult; Antiviral Agents; Biopsy; Clinical Competence; Drug Administration Schedule; Family Health; Guanine; Hepatitis B e Antigens; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Liver; Male; Middle Aged; Organophosphonates; Practice Patterns, Physicians'; Spain; Surveys and Questionnaires | 2009 |
M(2)-A induces apoptosis and G(2)-M arrest via inhibiting PI3K/Akt pathway in HL60 cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; DNA Fragmentation; Flow Cytometry; G2 Phase; HL-60 Cells; Humans; Microscopy, Fluorescence; Naphthalimides; Organophosphonates; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2009 |
The triple combination of tenofovir, emtricitabine and efavirenz shows synergistic anti-HIV-1 activity in vitro: a mechanism of action study.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cell Line; Cyclopropanes; Deoxycytidine; DNA, Viral; Drug Synergism; Emtricitabine; HIV Reverse Transcriptase; HIV-1; Humans; Organophosphonates; Tenofovir; Virus Replication | 2009 |
Emtricitabine/tenofovir disoproxil fumarate: in combination with a protease inhibitor in HIV-1 infection.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Organophosphonates; Tenofovir | 2009 |
Rhabdomyolysis in an HIV-infected patient on anti-retroviral therapy precipitated by high-dose pravastatin.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Dyslipidemias; Emtricitabine; HIV Infections; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Oligopeptides; Organophosphonates; Pravastatin; Pyridines; Rhabdomyolysis; Ritonavir; Tenofovir | 2009 |
Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only?
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; CD4 Lymphocyte Count; Dideoxynucleosides; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation, Missense; Organophosphonates; Retrospective Studies; Salvage Therapy; Tenofovir; Treatment Outcome; Viral Load; Zidovudine | 2009 |
Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.
Topics: Acids, Acyclic; Adenine; Antiviral Agents; Aza Compounds; Cidofovir; Cytosine; DNA Viruses; HeLa Cells; Humans; Molecular Structure; Nucleosides; Organophosphonates; RNA Viruses; Tenofovir | 2009 |
Long-term suppressive therapy for pulmonary aspergilloma in an immunocompromised man with AIDS. Is it always necessary?
Topics: Adenine; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antifungal Agents; Aspergillosis; Didanosine; Drug Administration Schedule; Drug Interactions; Fatal Outcome; HIV Infections; Humans; Immunocompromised Host; Lung Diseases, Fungal; Male; Middle Aged; Organophosphonates; Pancreatitis; Radiography; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2009 |
Reduced glomerular filtration rate but sustained virologic response in HIV/hepatitis B co-infected individuals on long-term tenofovir.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; CD4 Lymphocyte Count; Cohort Studies; Female; Glomerular Filtration Rate; Hepatitis B; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load | 2009 |
[Antiviral efficacy of lamivudine/adefovir combination therapy in chronic hepatitis b patients with resistance to lamivudine and adefovir consecutively].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors | 2009 |
[Treatment of hepatitis B virus resistant to lamivudine and adefovir].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates | 2009 |
Rapid HBV DNA decrease (week 12) is an important prognostic factor for first-line treatment with adefovir dipivoxil for chronic hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prognosis; Retrospective Studies; Viral Load | 2009 |
Tenofovir-associated renal and bone toxicity.
Topics: Adenine; Adult; Anti-HIV Agents; Creatinine; Fanconi Syndrome; Female; Glycosuria; HIV Infections; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules, Proximal; Male; Mass Screening; Middle Aged; Organophosphonates; Osteomalacia; Proteinuria; Radionuclide Imaging; Tenofovir | 2009 |
[Failure to treat hepatitis B virus infection with adefovir due to early selection of rtA181T mutation].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B Antigens; Hepatitis B virus; Humans; Male; Middle Aged; Mutation; Organophosphonates; Phenotype; Tenofovir; Time Factors; Treatment Failure | 2010 |
Tenofovir-related acute kidney injury and proximal tubule dysfunction precipitated by diclofenac: a case of drug-drug interaction.
Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Diagnosis, Differential; Diclofenac; Drug Synergism; Drug Therapy, Combination; Fanconi Syndrome; Female; HIV Antibodies; HIV Seropositivity; HIV-1; Humans; Kidney Tubules, Proximal; Middle Aged; Organophosphonates; Tenofovir | 2009 |
Tapping into combination pills for HIV.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Drug Combinations; Drug Industry; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Oxazines | 2009 |
Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Base Composition; China; Computational Biology; Databases, Genetic; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Phenotype; Phylogeny; RNA-Directed DNA Polymerase; Treatment Failure; Virus Replication; Young Adult | 2009 |
The simultaneous assay of tenofovir and emtricitabine in plasma using LC/MS/MS and isotopically labeled internal standards.
Topics: Adenine; Anti-HIV Agents; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Emtricitabine; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Sensitivity and Specificity; Tandem Mass Spectrometry; Tenofovir | 2009 |
[The clinical study of adding on adefovir dipivoxil to treat for lamivudine resistant patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Young Adult | 2009 |
Renal dysfunction in chronic hepatitis B patients treated with adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; Creatinine; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2009 |
[Therapy of chronic hepatitis B. Tenofovir--first choice in current EASL guidelines].
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Drug Resistance, Viral; Evidence-Based Medicine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Neoplasms; Organophosphonates; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2009 |
Chiral analysis of anti-acquired immunodeficiency syndrome drug, 9-(R)-[2-(phosphonomethoxy)propyl]adenine (tenofovir), and related antiviral acyclic nucleoside phosphonates by CE using beta-CD as chiral selector.
Topics: Adenine; Anti-HIV Agents; beta-Cyclodextrins; Cidofovir; Cytosine; Electrolytes; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Linear Models; Organophosphonates; Purines; Pyrimidines; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism; Tenofovir | 2009 |
FDA notifications. Tenofovir in India receives tentative approval.
Topics: Adenine; Drug Approval; HIV Infections; India; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2009 |
Monitoring of therapy in patients with chronic hepatitis B virus.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Monitoring; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Point Mutation; Sequence Analysis, DNA | 2010 |
Modeling the cost-effectiveness of different oral antiviral therapies in patients with chronic hepatitis B.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Cohort Studies; Cost-Benefit Analysis; DNA, Viral; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Markov Chains; Models, Economic; Organophosphonates; Quality-Adjusted Life Years; Tenofovir | 2009 |
Mitochondrial tubulopathy in tenofovir disoproxil fumarate-treated rats.
Topics: Adenine; Animals; Anti-HIV Agents; Didanosine; DNA, Mitochondrial; Electron Transport; Electron Transport Complex IV; Kidney Tubules, Proximal; Male; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Diseases; NADH Dehydrogenase; Organophosphonates; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety.
Topics: Adenine; Anti-HIV Agents; Anti-Infective Agents; Cell Line; Cellulose; Electric Impedance; Epithelial Cells; HIV; Humans; Inflammation; Naphthalenesulfonates; NF-kappa B; Organophosphonates; Polymers; Tenofovir; Tight Junctions; Virus Replication | 2009 |
Prevalence, viral replication efficiency and antiviral drug susceptibility of rtQ215 polymerase mutations within the hepatitis B virus genome.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Antiviral Agents; Base Sequence; Child; Cohort Studies; DNA Primers; Drug Resistance, Viral; Female; Gene Products, pol; Genome, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Iran; Lamivudine; Male; Middle Aged; Organophosphonates; Point Mutation; Virus Replication; Young Adult | 2009 |
Renal function in patients with preexisting renal disease receiving tenofovir-containing highly active antiretroviral therapy in the HIV outpatient study.
Topics: Adenine; Adult; Aged; Ambulatory Care Facilities; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; United States | 2009 |
Salvage therapy with tenofovir followed by adefovir maintenance in a cirrhotic patient with a lamivudine resistant HBV flare.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Salvage Therapy; Tenofovir; Viremia | 2009 |
HIV clinics are halting enrolment of new patients as funding stalls, MSF warns.
Topics: Adenine; Anti-HIV Agents; Developing Countries; Drug Costs; HIV Infections; Hospitals, Special; Humans; Organophosphonates; Stavudine; Tenofovir | 2009 |
The absence of HIV mutations in cerebrospinal fluid and in peripheral blood mononuclear cells during a regimen containing Trizivir plus tenofovir.
Topics: Adenine; Anti-HIV Agents; Cohort Studies; Drug Combinations; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Lamivudine; Leukocytes, Mononuclear; Mutation; Organophosphonates; Prospective Studies; Tenofovir; Viremia; Zidovudine | 2009 |
Dynamic changes of HBV quasispecies and deletion patterns in a chronic hepatitis B patient.
Topics: Adenine; Antiviral Agents; Cluster Analysis; DNA, Viral; Epitopes, B-Lymphocyte; Epitopes, T-Lymphocyte; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Phylogeny; Sequence Analysis, DNA; Sequence Deletion; Sequence Homology; Viral Proteins | 2009 |
Virological response to initial antiretroviral regimens containing abacavir or tenofovir.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load | 2009 |
Different models of HBeAg seroconversion predicated by on-treatment ALT and HBV DNA profiles.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Organophosphonates; Prognosis; Pyrimidinones; Retrospective Studies; Telbivudine; Thymidine; Young Adult | 2009 |
Efavirenz + emtricitabine + tenofovir: new combination. HIV infection: do not modify ongoing therapy just to use one less tablet. Better adherence than with separate dosing has not been demonstrated, while reduced efficacy is plausible.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Antiviral Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Approval; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Emtricitabine; Europe; HIV Infections; Humans; Organophosphonates; Oxazines; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2009 |
Tenofovir: new indication. In chronic hepatitis B: beware bone toxicity.
Topics: Adenine; Antiviral Agents; Bone and Bones; Bone Diseases; Double-Blind Method; Drug Approval; Europe; Fractures, Bone; Hepatitis B, Chronic; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Viremia; Virus Replication | 2009 |
Detection of the rtA181V/T and rtN236T mutations associated with resistance to adefovir dipivoxil using a ligase detection reaction assay.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Humans; Ligases; Mutation; Organophosphonates; Plasmids; RNA-Directed DNA Polymerase | 2009 |
Combination of Lamivudine and adefovir therapy in HBeAg-positive chronic hepatitis B patients with poor response to adefovir monotherapy.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Enzymes; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2010 |
Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine.
Topics: Adenine; Administration, Intravaginal; Animals; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Gels; Humans; Macaca nemestrina; Organophosphonates; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Vagina | 2009 |
High rates of active hepatitis B and C co-infections in HIV-1 infected Cameroonian adults initiating antiretroviral therapy.
Topics: Adenine; Adult; Age Factors; Anti-HIV Agents; Anti-Retroviral Agents; Cameroon; Comorbidity; Female; Hepacivirus; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis C; Hepatitis C Antibodies; HIV Infections; HIV-1; Humans; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Pregnancy; Retrospective Studies; Tenofovir; Transaminases | 2010 |
Lamivudine and adefovir resistance in children and young adults with chronic hepatitis B.
Topics: Adenine; Adolescent; Antiviral Agents; Child; Drug Administration Schedule; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Time Factors; Young Adult | 2010 |
Antiretroviral tissue kinetics: in vivo imaging using positron emission tomography.
Topics: Adenine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brain; Colon; Fluorine Radioisotopes; Lymph Nodes; Male; Organophosphonates; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Tenofovir; Testis | 2009 |
Effectiveness of antiretroviral regimens containing abacavir with tenofovir in treatment-experienced patients: predictors of virological response and drug resistance evolution in a multi-cohort study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Dideoxynucleosides; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation, Missense; Organophosphonates; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load; Viral Proteins | 2009 |
Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Creatinine; DNA, Viral; Drug Resistance, Viral; Fanconi Syndrome; Female; Hepatitis B; Hepatitis B virus; Humans; Kidney; Lamivudine; Male; Middle Aged; Organophosphonates; Phosphates; Renal Insufficiency; Serum; Treatment Outcome; Viral Load | 2010 |
Low efficacy of entecavir therapy in adefovir-refractory hepatitis B patients with prior lamivudine resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load | 2010 |
Efficacy and safety of boosted and unboosted atazanavir-containing antiretroviral regimens in real life: results from a multicentre cohort study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Cohort Studies; Drug Administration Schedule; Drug Interactions; Female; HIV Infections; HIV Protease Inhibitors; Humans; Kaplan-Meier Estimate; Male; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome; Viral Load | 2010 |
HIV therapy may be given safely in resource-limited settings without routine laboratory monitoring.
Topics: Adenine; Anti-HIV Agents; Diagnostic Tests, Routine; Glomerular Filtration Rate; Health Resources; HIV Infections; HIV-1; Humans; Incidence; Kidney Diseases; Laboratories; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Uganda; Zimbabwe | 2009 |
Renal function with use of a tenofovir-containing initial antiretroviral regimen.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Diseases; Longitudinal Studies; Male; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Antischistosomal activity of hexadecyloxypropyl cyclic 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine and other alkoxyalkyl esters of acyclic nucleoside phosphonates assessed by schistosome worm killing in vitro.
Topics: Adenine; Animals; Cricetinae; Mesocricetus; Molecular Structure; Organophosphonates; Schistosoma; Schistosomiasis; Schistosomicides | 2009 |
Clinical outcome of lamivudine-resistant chronic hepatitis B patients with compensated cirrhosis under adefovir salvage treatment. Importance of HCC surveillance.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Cohort Studies; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2009 |
Chronic hepatitis B: update 2009.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Organophosphonates; Practice Guidelines as Topic; Tenofovir | 2009 |
[Factors associated with response to lamivudine: retrospective study of 233 patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Treatment Outcome; Young Adult | 2009 |
Hepatitis B virus in tenofovir-naive Chinese patients with chronic hepatitis B contains no mutation of rtA194T conferring a reduced tenofovir susceptibility.
Topics: Adenine; Adult; Drug Resistance, Viral; Female; Gene Amplification; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir | 2009 |
Favorable outcome of de novo hepatitis B infection after liver transplantation with lamivudine and adefovir therapy.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis, Biliary; Liver Transplantation; Middle Aged; Organophosphonates; Treatment Outcome | 2009 |
Hepatitis B in HIV patients: what is the current treatment and what are the challenges?
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Nucleosides; Organophosphonates; Polyethylene Glycols; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Transaminases | 2009 |
Role of basolateral efflux transporter MRP4 in the intestinal absorption of the antiviral drug adefovir dipivoxil.
Topics: Adenine; Animals; Antiviral Agents; Biological Transport; Caco-2 Cells; Cell Line; Dogs; Humans; Intestinal Absorption; Kidney; Multidrug Resistance-Associated Proteins; Organophosphonates | 2010 |
Conserved T cell and natural killer cell function in treatment-experienced adults receiving tenofovir plus didanosine as nucleoside reverse transcription inhibitor backbone.
Topics: Adenine; Adult; CD4 Lymphocyte Count; Cell Proliferation; Didanosine; Drug Therapy, Combination; Flow Cytometry; Fluorescent Antibody Technique; Follow-Up Studies; HIV Infections; HIV-1; Humans; Immunologic Memory; Immunophenotyping; Interferon-gamma; Killer Cells, Natural; Lamivudine; Logistic Models; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Statistics, Nonparametric; T-Lymphocytes; Tenofovir | 2009 |
The significance of enzyme immunoassay for the assessment of hepatitis B virus core-related antigen following liver transplantation.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Female; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoenzyme Techniques; Lamivudine; Liver Transplantation; Living Donors; Male; Middle Aged; Organophosphonates; Time Factors; Virus Replication | 2009 |
Endocannabinoid 1 and 2 (CB(1); CB(2)) receptor agonists affect negatively cow luteal function in vitro.
Topics: Adenine; Adenosine; Animals; Arachidonic Acids; Cattle; Corpus Luteum; Dinoprost; Dinoprostone; Female; In Vitro Techniques; Indoles; Organophosphonates; Piperidines; Pregnancy; Progesterone; Pyrazoles; Pyrrolidines; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2009 |
[Medication change due to side effects or possible long-term complications. Side effect management with vision].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV-1; Humans; Long-Term Care; Lopinavir; Oligopeptides; Organophosphonates; Oxazines; Pyridines; Pyrimidinones; Pyrrolidinones; Raltegravir Potassium; Randomized Controlled Trials as Topic | 2009 |
[One year with Atripla. Changeover to complete HIV therapy in a single tablet has proven successful].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Controlled Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Medication Adherence; Organophosphonates; Oxazines; Viral Load | 2009 |
[Telbivudine in the management of HIV/HBV coinfection. Treating hepatitis B without HIV trouble].
Topics: Adenine; AIDS-Related Opportunistic Infections; Algorithms; Anti-HIV Agents; Antiviral Agents; Comorbidity; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Function Tests; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Thymidine | 2009 |
[Current data on antiretroviral therapy. CROI 2009: tenofovir DR convinces by high effectiveness and tolerance].
Topics: Adenine; Algorithms; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Clinical Trials as Topic; Dideoxynucleosides; Humans; Myocardial Infarction; Organophosphonates; Tenofovir; Treatment Outcome | 2009 |
[Tenofovir, An antiviral agent with activity against HIV infections and hepatitis B].
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Hepatitis B; Hepatitis B virus; Humans; Organophosphonates; Patient Education as Topic; Tenofovir; Virus Replication | 2009 |
Once-daily treatment with saquinavir mesylate (2000 mg) and ritonavir (100 mg) together with a fixed-dose combination of abacavir/lamivudine (600/300 mg) or tenofovir/emtricitabine (245/200 mg) in HIV-1-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Area Under Curve; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Plasma; Ritonavir; RNA, Viral; Saquinavir; Tenofovir; Treatment Outcome; Viral Load | 2009 |
On-line coupling of anion exchange and ion-pair chromatography for measurement of intracellular triphosphate metabolites of reverse transcriptase inhibitors.
Topics: Adenine; Chromatography, Ion Exchange; Deoxycytidine; Emtricitabine; Humans; Lamivudine; Leukocytes, Mononuclear; Mass Spectrometry; Organophosphonates; Polyphosphates; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Subclinical tubular injury in HIV-infected individuals on antiretroviral therapy: a cross-sectional analysis.
Topics: Acetylglucosaminidase; Adenine; Adult; Aged; Albuminuria; Anti-Retroviral Agents; Creatinine; Cross-Sectional Studies; Disease Progression; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Tubules, Proximal; Male; Middle Aged; Organophosphonates; Phosphates; Proteinuria; Retinol-Binding Proteins; Risk Factors; Sensitivity and Specificity; Tenofovir | 2009 |
[Non-standard discontinuation of adefovir dipivoxil causing acute exacerbation of hepatitis].
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Critical Illness; Cytokines; DNA, Viral; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lymphocyte Count; Male; Organophosphonates; Recurrence; T-Lymphocytes; Time Factors; Treatment Outcome | 2009 |
Structural basis for the role of the K65R mutation in HIV-1 reverse transcriptase polymerization, excision antagonism, and tenofovir resistance.
Topics: Adenine; Arginine; Crystallization; Crystallography, X-Ray; Drug Resistance, Viral; HIV Reverse Transcriptase; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutation; Organophosphonates; Protein Conformation; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Lower limb high arterial flow induced by tenofovir and emtricitabine treatment.
Topics: Adenine; Adult; Blood Flow Velocity; Deoxycytidine; Edema; Emtricitabine; HIV Infections; Humans; Leg; Male; Organophosphonates; Tenofovir | 2009 |
Two types of drug-resistant hepatitis B viral strains emerging alternately and their susceptibility to combination therapy with entecavir and adefovir.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B; Hepatitis B virus; Humans; Male; Middle Aged; Organophosphonates | 2009 |
Impact of tenofovir on renal function in HIV-infected, antiretroviral-naive patients.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Creatinine; Fanconi Syndrome; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Function Tests; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Tenofovir | 2010 |
The art of managing human immunodeficiency virus infection: a balancing act.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Emtricitabine; HIV Infections; Humans; Lamivudine; Organophosphonates; Tenofovir; Treatment Outcome | 2009 |
[Acute renal failure and hypercalcemia in an AIDS patient on tenofovir and low-dose vitamin D therapy with immune reconstitution inflammatory syndrome].
Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adenine; Adrenal Cortex Hormones; Adult; AIDS-Related Opportunistic Infections; Alkynes; Anti-HIV Agents; Antitubercular Agents; Benzoxazines; Calcium; Cholecalciferol; Cyclopropanes; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; Humans; Hypercalcemia; Immune Reconstitution Inflammatory Syndrome; Kidney Function Tests; Mycobacterium avium-intracellulare Infection; Organophosphonates; Osteoporosis; Tenofovir | 2009 |
Tenofovir coadministration is not associated with lower unboosted atazanavir plasma exposure in the clinical setting.
Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; Drug Interactions; Drug Therapy, Combination; Female; History, 17th Century; HIV Infections; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Tenofovir | 2009 |
[The efficacy of nucleoside/nucleotide analogue on chronic hepatitis B].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2009 |
[Dissection of mechanism for the adefovir dipivoxil resistance in chronic hepatitis B patients].
Topics: Adenine; Adult; Alanine Transaminase; Amino Acid Sequence; Antiviral Agents; Base Sequence; DNA Primers; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Molecular Sequence Data; Organophosphonates; Polymorphism, Genetic; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Sequence Analysis, DNA | 2009 |
Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells.
Topics: Adenine; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Cycle Proteins; Checkpoint Kinase 2; DNA Breaks, Double-Stranded; DNA-Binding Proteins; Flow Cytometry; Fluorescent Antibody Technique; G2 Phase; HCT116 Cells; Humans; Naphthalimides; Organophosphonates; Protein Serine-Threonine Kinases; RNA, Small Interfering; Signal Transduction; Thiophenes; Transfection; Tumor Suppressor Proteins | 2009 |
Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Drug Design; Hepatitis B virus; Humans; Organophosphonates; Organophosphorus Compounds; Prodrugs | 2009 |
Resolution of chronic hepatitis Delta after 1 year of combined therapy with pegylated interferon, tenofovir and emtricitabine.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Therapy, Combination; Emtricitabine; Hepatitis B; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; RNA, Viral; Tenofovir; Treatment Outcome | 2010 |
Safety and efficacy of once-daily nevirapine dosing: a multicohort study.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Drug Administration Schedule; Drug Hypersensitivity; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nevirapine; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome | 2009 |
Evolution of hepatitis B virus mutation during entecavir rescue therapy in patients with antiviral resistance to lamivudine and adefovir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Evolution, Molecular; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome | 2009 |
A new drug combination therapy for treatment-naive patients with HIV-1 infection, consisting of raltegravir, emtricitabine and tenofovir disoproxil fumarate.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Tenofovir | 2009 |
Tenofovir disoproxil fumarate for the treatment of hepatitis B infection.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Hepatitis B, Chronic; Humans; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Anti-Retroviral Agents; Compressive Strength; Delayed-Action Preparations; Drug Combinations; Drug Delivery Systems; Organophosphonates; Polyurethanes; Pyrimidines; Tenofovir | 2010 |
FDA notifications. FDA approves generic combination of efavirenz, lamivudine & tenofovir.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Approval; Drug Combinations; Drugs, Generic; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; United States; United States Food and Drug Administration | 2009 |
Long-term efficacy of tenofovir monotherapy for hepatitis B virus-monoinfected patients after failure of nucleoside/nucleotide analogues.
Topics: Adenine; Adolescent; Adult; Cohort Studies; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome | 2010 |
Decrease in viral load at weeks 12 and 24 in patients with chronic hepatitis B treated with lamivudine or adefovir predicts virological response at week 48.
Topics: Adenine; Adult; Antiviral Agents; Female; Forecasting; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Prospective Studies; Retrospective Studies; Reverse Transcriptase Inhibitors; Time Factors; Viral Load | 2009 |
Prevalence and factors associated with renal impairment in HIV-infected patients, ANRS C03 Aquitaine Cohort, France.
Topics: Adenine; Adult; Anti-HIV Agents; Body Mass Index; CD4 Lymphocyte Count; Creatinine; Epidemiologic Methods; Female; France; HIV Infections; Humans; Hypertension; Indinavir; Kidney; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Tenofovir | 2010 |
Selection and counterselection of the rtI233V adefovir resistance mutation during antiviral therapy.
Topics: Adenine; Adult; Amino Acid Sequence; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Molecular Sequence Data; Mutation, Missense; Organophosphonates; Selection, Genetic; Sequence Alignment; Tenofovir; Treatment Failure; Viremia; Young Adult | 2010 |
Low-abundance HIV species and their impact on mutational profiles in patients with virological failure on once-daily abacavir/lamivudine/zidovudine and tenofovir.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Drug Combinations; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Middle Aged; Mutation, Missense; Organophosphonates; RNA, Viral; Tenofovir; Treatment Failure; Viremia; Young Adult; Zidovudine | 2010 |
Early clinical and programmatic outcomes with tenofovir-based antiretroviral therapy in Zambia.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Male; Organophosphonates; Tenofovir; Treatment Outcome; Zambia | 2010 |
N348I in HIV-1 reverse transcriptase decreases susceptibility to tenofovir and etravirine in combination with other resistance mutations.
Topics: Adenine; Drug Resistance, Multiple, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutagenesis, Site-Directed; Mutation; Nitriles; Organophosphonates; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
Downregulation of Gnas, Got2 and Snord32a following tenofovir exposure of primary osteoclasts.
Topics: Adenine; Animals; Anti-HIV Agents; Aspartate Aminotransferase, Mitochondrial; Bone Density; Cell Survival; Cells, Cultured; Chromogranins; Down-Regulation; Gene Expression; GTP-Binding Protein alpha Subunits, Gs; Mice; Oligonucleotide Array Sequence Analysis; Organophosphonates; Osteoclasts; Osteoporosis; RNA, Small Nucleolar; Tenofovir | 2010 |
[Protocol for the antiviral therapy of hepatitis B and D].
Topics: Adenine; Antiviral Agents; Biopsy; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis D; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Interferons; Lamivudine; Liver Cirrhosis; Nucleotides; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2010 |
Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety.
Topics: Adenine; Administration, Intravaginal; Animals; Anti-Infective Agents; Antiviral Agents; Biomarkers; Disease Models, Animal; Disease Susceptibility; Female; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; Mice; Mice, Inbred BALB C; Naphthalenesulfonates; Nonoxynol; Organophosphonates; Polymers; Predictive Value of Tests; Risk Assessment; Tenofovir | 2009 |
Serum levels of surface large envelope proteins: prognostic markers for hepatitis B e antigen-negative patients with adefovir dipivoxil treatment.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Membrane Proteins; Middle Aged; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; ROC Curve; Treatment Outcome | 2009 |
FDA notifications. Generic efavirenz/emtricitabine/fenofovir has tentative approval.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Approval; Drug Combinations; Drugs, Generic; Emtricitabine; HIV Infections; Humans; Organophosphonates; Tenofovir; United States; United States Food and Drug Administration | 2009 |
Cost-effectiveness of tenofovir as first-line antiretroviral therapy in India.
Topics: Adenine; Adult; Antifungal Agents; Antiretroviral Therapy, Highly Active; Cost-Benefit Analysis; Female; HIV Infections; Humans; India; Male; Organophosphonates; Stavudine; Survival Analysis; Tenofovir; Treatment Outcome; Zidovudine | 2010 |
Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Lamivudine; Lopinavir; Male; Middle Aged; Nevirapine; Oligopeptides; Organophosphonates; Proportional Hazards Models; Prospective Studies; Pyridines; Pyrimidinones; Risk Factors; Switzerland; Tenofovir; Zidovudine | 2010 |
DAART for human immunodeficiency virus-infected patients: Studying subjects not at risk for nonadherence and use of untested interventions.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Aged; Anti-HIV Agents; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Viral; Emtricitabine; Female; Genotype; HIV Infections; HIV-1; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Patient Compliance; Pyrimidinones; Randomized Controlled Trials as Topic; RNA, Viral; Stavudine; Tenofovir; Treatment Outcome; Young Adult | 2010 |
Microbicide research already benefiting thousands--experts.
Topics: Adenine; Anti-HIV Agents; Anti-Infective Agents; Anti-Retroviral Agents; Biomedical Research; HIV Infections; Humans; Organophosphonates; Tenofovir; Vaginal Creams, Foams, and Jellies | 2009 |
Expanded postexposure prophylaxis for simultaneous multiple source HIV exposure in a health-care worker.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Darunavir; Deoxycytidine; Emtricitabine; Enfuvirtide; Female; Fingers; HIV Envelope Protein gp41; HIV Infections; Humans; Infectious Disease Transmission, Patient-to-Professional; Middle Aged; Needlestick Injuries; Occupational Diseases; Organophosphonates; Peptide Fragments; Post-Exposure Prophylaxis; Ritonavir; Sulfonamides; Tenofovir | 2010 |
Incidence of proximal renal tubular dysfunction in patients on tenofovir disoproxil fumarate.
Topics: Adenine; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; Humans; Incidence; Organophosphonates; Retrospective Studies; Tenofovir; United Kingdom | 2010 |
Tolerability of two different combinations of antiretroviral drugs including tenofovir used in occupational and nonoccupational postexposure prophylaxis for HIV.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; Humans; Infectious Disease Transmission, Patient-to-Professional; Male; Occupational Exposure; Occupational Health Services; Organophosphonates; Patient Compliance; Tenofovir | 2010 |
Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice.
Topics: Adenine; Animals; Anti-HIV Agents; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Flow Cytometry; HIV Infections; HIV-1; Mice; Organophosphonates; Rectum; Tenofovir | 2010 |
[The antiviral treatment impacts on clinical outcomes of renal transplantation recipients with hepatitis B virus infection].
Topics: Adenine; Adult; Aged; Antiviral Agents; Case-Control Studies; Female; Hepatitis B; Hepatitis B virus; Humans; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2009 |
Hepatitis B viral surface mutations in patients with adefovir resistant chronic hepatitis B with A181T/V polymerase mutations.
Topics: Adenine; Adult; Aged; Amino Acid Sequence; Amino Acid Substitution; Antiviral Agents; Codon, Initiator; Demography; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Point Mutation; Viral Proteins | 2010 |
Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry.
Topics: Adenine; Adenine Nucleotides; Anions; Chromatography, Ion Exchange; Deoxycytidine; Drug Stability; Emtricitabine; Humans; Leukocytes, Mononuclear; Linear Models; Nucleotides; Organophosphonates; Phosphorylation; Pyrimidine Nucleotides; Reproducibility of Results; Tandem Mass Spectrometry; Tenofovir | 2010 |
International cohort analysis of the antiviral activities of zidovudine and tenofovir in the presence of the K65R mutation in reverse transcriptase.
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; California; Cohort Studies; Drug Resistance, Viral; France; Genes, Viral; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Multivariate Analysis; Mutation, Missense; Organophosphonates; RNA, Viral; Tenofovir; Zidovudine | 2010 |
Emerging mutations at virological failure of HAART combinations containing tenofovir and lamivudine or emtricitabine.
Topics: Adenine; Adult; Analysis of Variance; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Mutation; Organophosphonates; Retrospective Studies; RNA, Viral; Tenofovir; Treatment Failure; Viral Load | 2010 |
Hypophosphatemic osteomalacia after low-dose adefovir dipivoxil therapy for hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Hepatitis B, Chronic; Humans; Hypophosphatemia; Magnetic Resonance Imaging; Male; Organophosphonates; Osteomalacia | 2010 |
Effect of tenofovir disoproxil fumarate on risk of renal abnormality in HIV-1-infected children on antiretroviral therapy: a nested case-control study.
Topics: Adenine; Adolescent; Anti-HIV Agents; Case-Control Studies; Child; Child, Preschool; England; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Hypophosphatemia; Ireland; Kidney; Male; Organophosphonates; Salvage Therapy; Tenofovir; Treatment Outcome | 2010 |
The case: 41-year-old HIV patient with proteinuria and progressive renal dysfunction. Tenofovir toxicity.
Topics: Adenine; Adult; Anti-HIV Agents; Biopsy; Disease Progression; Humans; Kidney; Kidney Diseases; Kidney Tubules, Proximal; Male; Organophosphonates; Proteinuria; Tenofovir | 2010 |
Recent FDA approvals and changes.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Drug Approval; Drug Combinations; Drug Labeling; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Oxazines; Randomized Controlled Trials as Topic; United States; United States Food and Drug Administration | 2010 |
Safety and efficacy of tenofovir/emtricitabine plus nevirapine in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Male; Nevirapine; Organophosphonates; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2010 |
A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosis.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Binding, Competitive; Cell Line, Tumor; Cell Survival; Circular Dichroism; DNA; DNA Topoisomerases, Type II; Drug Design; HeLa Cells; HL-60 Cells; Humans; Inhibitory Concentration 50; Intracellular Membranes; Lysosomes; Models, Chemical; Molecular Structure; Naphthalimides; Organophosphonates; Permeability; Plasmids; Spectrometry, Fluorescence; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2010 |
Tenofovir treatment of primary osteoblasts alters gene expression profiles: implications for bone mineral density loss.
Topics: Adenine; Animals; Anti-HIV Agents; Bone Density; Bone Resorption; Gene Expression; Mice; Mice, Inbred C57BL; Organophosphonates; Osteoblasts; Prodrugs; Tenofovir | 2010 |
Incomplete reversibility of tenofovir-related renal toxicity in HIV-infected men.
Topics: Adenine; Anti-HIV Agents; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Organophosphonates; Tenofovir; Withholding Treatment | 2010 |
In vitro and ex vivo testing of tenofovir shows it is effective as an HIV-1 microbicide.
Topics: Adenine; Anti-HIV Agents; Caco-2 Cells; Cell Survival; Cells, Cultured; Cervix Uteri; Colon; Drug Evaluation, Preclinical; Female; Gels; HIV-1; Humans; Leukocytes, Mononuclear; Organophosphonates; Rectum; Tenofovir; Tissue Culture Techniques | 2010 |
B1, a novel naphthalimide-based DNA intercalator, induces cell cycle arrest and apoptosis in HeLa cells via p53 activation.
Topics: Adenine; Apoptosis; Benzothiazoles; Caspases; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cell Shape; Cell Survival; Cytochromes c; DNA, Neoplasm; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescence; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Intercalating Agents; Mitochondria; Naphthalimides; Necrosis; Organophosphonates; RNA, Messenger; RNA, Small Interfering; Staining and Labeling; Time Factors; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2011 |
Synthesis of 3'-o-phosphonoethyl nucleosides with an adenine and a thymine base moiety.
Topics: Adenine; Antiviral Agents; Cell Line; Cell Survival; Hepacivirus; HIV; Humans; Microbial Sensitivity Tests; Nucleosides; Organophosphonates; Thymine | 2009 |
Nucleoside diphosphate kinase and the activation of antiviral phosphonate analogs of nucleotides: binding mode and phosphorylation of tenofovir derivatives.
Topics: Adenine; Antiviral Agents; Binding Sites; Crystallography, X-Ray; Dictyostelium; Escherichia coli; Humans; Models, Molecular; Nucleoside-Diphosphate Kinase; Nucleotides; Organophosphonates; Phosphorylation; Recombinant Proteins; Reverse Transcriptase Inhibitors; Substrate Specificity; Tenofovir | 2009 |
Evolution of full-length HBV sequences in chronic hepatitis B patients with sequential lamivudine and adefovir dipivoxil resistance.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Epitopes, B-Lymphocyte; Epitopes, T-Lymphocyte; Evolution, Molecular; Female; Gene Products, pol; Genome, Viral; Genotype; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Phylogeny; Reverse Transcriptase Inhibitors; Young Adult | 2010 |
Tenofovir and changes in renal function.
Topics: Adenine; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
Near-infrared investigations of novel anti-HIV tenofovir liposomes.
Topics: Adenine; Amines; Anti-HIV Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Drug Compounding; Electrochemistry; Excipients; Freeze Drying; Least-Squares Analysis; Liposomes; Organophosphonates; Particle Size; Phospholipids; Spectroscopy, Fourier Transform Infrared; Spectroscopy, Near-Infrared; Tenofovir; Ultracentrifugation; X-Ray Diffraction | 2010 |
A controlled trial of initial antiviral regimens for HIV-1 infection.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Genotype; HIV Infections; HIV-1; Homosexuality, Male; Humans; Lamivudine; Male; Organophosphonates; Tenofovir; Treatment Failure | 2010 |
Single-tablet Quad regimen achieves high rate of virologic suppression.
Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Clinical Trials, Phase II as Topic; Cytochrome P-450 CYP3A Inhibitors; Deoxycytidine; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV-1; Humans; Multicenter Studies as Topic; Oligopeptides; Organophosphonates; Organophosphorus Compounds; Oxazines; Pyridines; Quinolones; Randomized Controlled Trials as Topic; Ritonavir; Treatment Outcome; Viral Load | 2010 |
Antiproliferative effects of octadecyloxyethyl 9-[2-(phosphonomethoxy)ethyl]guanine against Me-180 human cervical cancer cells in vitro and in vivo.
Topics: Adenine; Animals; Antineoplastic Agents; Female; Guanine; HeLa Cells; Humans; Mice; Mice, Nude; Organophosphonates; Organophosphorus Compounds; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2010 |
Disseminated bartonellosis presenting as neuroretinitis in a young adult with human immunodeficiency virus infection.
Topics: Adenine; Anti-Bacterial Agents; Anti-HIV Agents; Bartonella; Bartonella Infections; Biopsy; Deoxycytidine; Doxycycline; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Lung; Male; Organophosphonates; Oxazines; Retinitis; Rifampin; Treatment Outcome; Young Adult | 2010 |
Establishment of a new quantitative detection approach to adefovir-resistant HBV and its clinical application.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Sensitivity and Specificity; Sequence Analysis, DNA; Young Adult | 2010 |
Development of an LC-MS method for measuring TNF in human vaginal tissue.
Topics: Adenine; Anti-HIV Agents; Calibration; Chromatography, Liquid; Female; Humans; Limit of Detection; Organophosphonates; Spectrometry, Mass, Electrospray Ionization; Tenofovir; Vagina | 2010 |
Hepatitis B genotypes and response to adefovir treatment in patients with HBV chronic infection.
Topics: Adenine; Antiviral Agents; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Treatment Outcome | 2010 |
Efficacy of tenofovir-emtricitabine versus abacavir-lamivudine.
Topics: Adenine; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; HIV Infections; Humans; Lamivudine; Organophosphonates; Tenofovir; Treatment Outcome | 2010 |
Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy.
Topics: Adenine; Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cell Line; Cells, Cultured; Deoxycytidine; DNA, Viral; Emtricitabine; Humans; Macaca mulatta; Organophosphonates; Proviruses; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load | 2010 |
Elvucitabine data released at CROI.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Clinical Trials, Phase II as Topic; Cyclopropanes; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load; Zalcitabine | 2010 |
Impairment in kidney tubular function in patients receiving tenofovir is associated with higher tenofovir plasma concentrations.
Topics: Adenine; HIV Infections; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
Liver transplantation in bearers of hepatitis B associated or not with delta hepatitis in the age of the new antiviral drugs: is hyperimmune globulin still necessary?
Topics: Adenine; Adult; Aged; Antiviral Agents; Aspartate Aminotransferases; Female; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis D; Humans; Liver Transplantation; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Recurrence; Retrospective Studies; Young Adult | 2010 |
Response to adefovir depends on mutation patterns in precore region, basal core promoter and reverse transcriptase, and on-treatment responses in Lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Promoter Regions, Genetic; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Treatment Outcome; Viral Load | 2010 |
Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.
Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cytidine Deaminase; Gammaretrovirus; Humans; Leukemia Virus, Murine; Male; Mice; Mutation; Organophosphonates; Prostatic Neoplasms; Pyrrolidinones; Raltegravir Potassium; Retroviridae Infections; Tenofovir; Tumor Virus Infections; Zidovudine | 2010 |
Second-line treatment in the Malawi antiretroviral programme: high early mortality, but good outcomes in survivors, despite extensive drug resistance at baseline.
Topics: Adenine; Adolescent; Adult; Anti-Retroviral Agents; Body Mass Index; CD4 Lymphocyte Count; Developing Countries; Drug Resistance, Viral; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Genotype; HIV Infections; HIV-1; Humans; Malawi; Male; Medication Adherence; Middle Aged; National Health Programs; Organophosphonates; Prospective Studies; RNA, Viral; Statistics as Topic; Tenofovir; Treatment Failure; Tuberculosis; Urban Population; Viral Load; Zidovudine | 2010 |
Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern.
Topics: Adenine; Adolescent; Adult; Aged; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Inhibitory Concentration 50; Kaplan-Meier Estimate; Lamivudine; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Point Mutation; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Young Adult | 2011 |
Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.
Topics: Adenine; Administration, Oral; Animals; Deoxycytidine; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Kinetics; Leukocytes, Mononuclear; Macaca; Organophosphonates; Organophosphorus Compounds; Proportional Hazards Models; Rectum; Research Design; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Treatment Outcome; Viral Load | 2010 |
[Tenofovir associated hypokalaemia in a patient with normal renal function].
Topics: Adenine; Adult; Female; Humans; Hypokalemia; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
[Fanconi syndrome associated with tenofovir treatment: a presentation of two cases].
Topics: Adenine; Adult; Fanconi Syndrome; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
Cost-effectiveness analysis of roadmap models in chronic hepatitis B using tenofovir as the rescue therapy.
Topics: Adenine; Antiviral Agents; Asia; Cost-Benefit Analysis; Decision Support Techniques; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Germany; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Models, Economic; Nucleosides; Organophosphonates; Pyrimidinones; Salvage Therapy; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; United States | 2010 |
Positive and negative drug selection pressures on the N348I connection domain mutation: new insights from in vivo data.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Case-Control Studies; Cyclopropanes; Databases, Genetic; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; HIV Reverse Transcriptase; HIV-1; Humans; Logistic Models; Mutation; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir; Zidovudine | 2010 |
Tenofovir/probenecid combination in HIV/HBV-coinfected patients: how to escape Fanconi syndrome recurrence?
Topics: Adenine; Fanconi Syndrome; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Probenecid; Secondary Prevention; Tenofovir | 2010 |
Findings in humanized-mouse model suggest benefit of further studies in HIV pre-exposure prophylaxis.
Topics: Adenine; Animals; Anti-HIV Agents; Bone Marrow Transplantation; Clinical Trials as Topic; Deoxycytidine; Disease Models, Animal; Drug Combinations; Emtricitabine; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV; HIV Antibodies; HIV Infections; Humans; Infection Control; Liver Transplantation; Mice; Occupational Exposure; Organophosphonates; Organophosphorus Compounds; Tenofovir; Thymus Gland; Transplantation Chimera | 2010 |
Naturally occurring hepatitis B virus (HBV) variants with primary resistance to antiviral therapy and S-mutants with potential primary resistance to adefovir in Argentina.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Argentina; Child; Child, Preschool; Drug Resistance, Viral; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation, Missense; Organophosphonates; Retrospective Studies | 2010 |
Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.
Topics: Adenine; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Dogs; Drug Design; Drug Resistance, Viral; Drug Stability; Guanosine; HIV-1; Nucleosides; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured | 2010 |
Viral resistance in hepatitis B: prevalence and management.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Genetic Testing; Genotype; Guanine; Hepatitis B; Humans; Lamivudine; Nucleosides; Organophosphonates; Phenotype; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2010 |
Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.
Topics: Adenine; Anti-HIV Agents; Cell Survival; Cells, Cultured; Drug Resistance, Viral; HIV Infections; HIV-1; Humans; Macrophages; Nucleosides; Nucleotides; Organophosphonates; Tenofovir | 2010 |
Development of a validated liquid chromatographic method for the determination of related substances and assay of tenofovir disoproxil fumarate.
Topics: Adenine; Chromatography, Liquid; Limit of Detection; Organophosphonates; Reproducibility of Results; Reverse Transcriptase Inhibitors; Spectrophotometry, Ultraviolet; Tenofovir | 2010 |
[Serological and sociodemographic differences in HBV-patients with and without migration background].
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Comorbidity; Cross-Sectional Studies; Educational Status; Emigrants and Immigrants; Female; Germany; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Hepatitis C, Chronic; HIV Seropositivity; Humans; Incidence; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Outpatient Clinics, Hospital; Socioeconomic Factors; Unemployment; Viral Load; Young Adult | 2010 |
Raltegravir, tenofovir, and emtricitabine in an HIV-infected patient with HCV chronic hepatitis, NNRTI intolerance and protease inhibitors-induced severe liver toxicity.
Topics: Adenine; Adult; Antiviral Agents; CD4-Positive T-Lymphocytes; Chemical and Drug Induced Liver Injury; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis C, Chronic; HIV Infections; Humans; Liver; Lymphocyte Count; Organophosphonates; Protease Inhibitors; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Treatment Outcome; Viral Load | 2010 |
Report from the 17th Conference on Retroviruses and Opportunistic Infections. Randomized studies of once-daily darunavir and tenofovir/FTC + nevirapine.
Topics: Adenine; Anti-HIV Agents; Darunavir; Drug Administration Schedule; Drug Therapy, Combination; HIV Infections; Humans; Nevirapine; Organophosphonates; Randomized Controlled Trials as Topic; Sulfonamides; Tenofovir | 2010 |
Recent FDA approvals and changes.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Child; Delayed-Action Preparations; Didanosine; Drug Approval; Drug Labeling; HIV Infections; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir; United States; United States Food and Drug Administration | 2010 |
[Protease inhibitor or non-nucleoside reverse transcriptase inhibitor. ACTG study 5202 in focus].
Topics: Adenine; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV Protease Inhibitors; HIV Reverse Transcriptase; Humans; Lamivudine; Multicenter Studies as Topic; Oligopeptides; Organophosphonates; Pyridines; Randomized Controlled Trials as Topic; Tenofovir | 2010 |
[HIV-therapy-associated immune reconstitution syndrome presenting as immunogenic hyperthyroidism].
Topics: Adenine; Alkynes; Anti-HIV Agents; Autoantibodies; Benzoxazines; Cyclopropanes; Deoxycytidine; Diagnosis, Differential; Drug Therapy, Combination; Emtricitabine; Graves Disease; HIV Infections; HIV-1; Humans; Immune Reconstitution Inflammatory Syndrome; Long-Term Care; Male; Middle Aged; Organophosphonates; Tenofovir; Thyroid Gland; Thyroiditis, Autoimmune | 2010 |
Prevalence and factors associated with renal dysfunction among HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cross-Sectional Studies; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Military Hygiene; Military Personnel; Organophosphonates; Prevalence; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir; Time Factors | 2010 |
Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/nucleotide inhibitors.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Arabinofuranosyluracil; Cell Line; Cells, Cultured; Drug Antagonism; Drug Synergism; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Microbial Sensitivity Tests; Nucleosides; Nucleotides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine | 2010 |
Clonal resistance analyses of HIV type-1 after failure of therapy with didanosine, lamivudine and tenofovir.
Topics: Adenine; Anti-HIV Agents; Didanosine; Drug Resistance, Viral; Drug Therapy, Combination; Genome, Viral; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Phenotype; Recombination, Genetic; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Tenofovir; Treatment Failure | 2010 |
Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Disease Progression; Epidemiologic Methods; Female; Glomerular Filtration Rate; HIV Seropositivity; HIV-1; Humans; Indinavir; Kidney Failure, Chronic; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
Metal ion-binding properties of 9-[(2-phosphonomethoxy)ethyl]-2-aminopurine (PME2AP), an isomer of the antiviral nucleotide analogue 9-[(2-phosphonomethoxy)ethyl]adenine (PMEA). Steric guiding of metal ion-coordination by the purine-amino group.
Topics: 2-Aminopurine; Adenine; Antiviral Agents; Coordination Complexes; Isomerism; Metals; Organophosphonates; Oxygen | 2010 |
Advantages of low-cost generic tenofovir instead of D4T for first-line antiretroviral therapy in Burma: a 2-year experience.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cost-Benefit Analysis; HIV Infections; Humans; Myanmar; Organophosphonates; Tenofovir | 2010 |
[Genotype distribution of chronic hepatitis B and hepatitis C patients and investigation of the resistance patterns in hepatitis B cases].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA Mutational Analysis; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepacivirus; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Young Adult | 2010 |
Cost-effectiveness of nucleoside analog therapy for hepatitis B in China: a Markov analysis.
Topics: Adenine; Antiviral Agents; China; Cost-Benefit Analysis; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Markov Chains; Models, Economic; Models, Statistical; Monte Carlo Method; Nucleosides; Organophosphonates; Pyrimidinones; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Serologic Tests; Telbivudine; Thymidine | 2010 |
Long-term outcome of renal transplant recipients with chronic hepatitis B infection-impact of antiviral treatments.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Diseases; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Viral Load | 2010 |
Absorption enhancement of adefovir dipivoxil by incorporating MCT and ethyl oleate complex oil phase in emulsion.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Area Under Curve; Biological Availability; Emulsions; Enzyme Inhibitors; Esterases; Inhibitory Concentration 50; Intestinal Absorption; Intestinal Mucosa; Male; Oleic Acids; Organophosphonates; Rats; Rats, Sprague-Dawley; Triglycerides | 2010 |
The exploitation of "Exploitation" in the tenofovir prep trial in Cameroon: Lessons learned from media coverage of an HIV prevention trial.
Topics: Adenine; Anti-HIV Agents; Cameroon; Ethics, Research; Female; HIV Infections; Human Rights; Humans; Internationality; Mass Media; Organophosphonates; Persuasive Communication; Problem Solving; Public Relations; Randomized Controlled Trials as Topic; Tenofovir; Vulnerable Populations | 2010 |
Peptide nucleic acid array for detection of point mutations in hepatitis B virus associated with antiviral resistance.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Microbial Sensitivity Tests; Mutation, Missense; Oligonucleotide Array Sequence Analysis; Organophosphonates; Peptide Nucleic Acids; Point Mutation; Sensitivity and Specificity | 2010 |
Economic efficiency of genetic screening to inform the use of abacavir sulfate in the treatment of HIV.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Computer Simulation; Cost-Benefit Analysis; Decision Trees; Dideoxynucleosides; Drug Hypersensitivity; Drug-Related Side Effects and Adverse Reactions; Genetic Testing; HIV Infections; HLA-B Antigens; Humans; Middle Aged; Models, Economic; Organophosphonates; Quality-Adjusted Life Years; Tenofovir; United States | 2010 |
Acute hepatitis B infection associated with drug-resistant hepatitis B virus.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Organophosphonates; Polymerase Chain Reaction; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Viral Proteins | 2010 |
Lack of interaction between the HIV integrase inhibitor S/GSK1349572 and tenofovir in healthy subjects.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Interactions; Female; HIV Integrase Inhibitors; Human Experimentation; Humans; Male; Middle Aged; Organophosphonates; Plasma; Tenofovir | 2010 |
rtE218G, a novel hepatitis B virus mutation with resistance to adefovir dipivoxil in patients with chronic hepatitis B.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Cell Line; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Mutation, Missense; Organophosphonates; RNA-Directed DNA Polymerase; Sequence Analysis, DNA | 2010 |
Drug therapy: tenofovir.
Topics: Adenine; Antiviral Agents; Female; Hepatitis B; Humans; Middle Aged; Organophosphonates; Tenofovir | 2010 |
Antitumor effects of guanosine-analog phosphonates identified by molecular modelling.
Topics: Adenine; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Fluorouracil; HT29 Cells; Humans; Keratinocytes; Keratosis, Actinic; Models, Molecular; Molecular Dynamics Simulation; Organophosphonates | 2010 |
Lamivudine-resistance mutations can be selected even at very low levels of hepatitis B viraemia.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load; Viremia | 2010 |
Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.
Topics: Adenine; Animals; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Deoxycytidine; Emtricitabine; Interleukin-7; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Tenofovir | 2010 |
Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; Asian People; DNA, Circular; DNA, Viral; Drug Resistance; Female; Gene Products, pol; Genetic Variation; Genome, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver; Liver Transplantation; Male; Middle Aged; Organophosphonates; Phylogeny; Tenofovir; Trans-Activators; Viral Envelope Proteins; Viral Regulatory and Accessory Proteins; Virus Replication | 2011 |
FDA notifications. Updated Atripla label approved.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Drug Labeling; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Oxazines; Viral Load | 2010 |
Rapid HIV-RNA decline following addition of raltegravir and tenofovir to ongoing highly active antiretroviral therapy in a woman presenting with high-level HIV viraemia at week 38 of pregnancy.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Pyrrolidinones; Raltegravir Potassium; RNA, Viral; Tenofovir; Viral Load; Viremia | 2010 |
Immunodeficiency and renal impairment are risk factors for HIV-associated acute renal failure.
Topics: Acute Kidney Injury; Adenine; Adult; Atazanavir Sulfate; CD4 Lymphocyte Count; Cohort Studies; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Indinavir; London; Male; Oligopeptides; Organophosphonates; Pyridines; Risk Factors; Tenofovir | 2010 |
More research needed to find new HIV-suppressive functions of cytotoxic T cells.
Topics: Adenine; Animals; Combined Modality Therapy; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Lymphocyte Depletion; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Tenofovir; Viral Load; Viremia | 2010 |
HIV/AIDS. At last, vaginal gel scores victory against HIV.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Anti-Infective Agents, Local; Female; HIV Infections; HIV-1; Humans; Medication Adherence; Organophosphonates; Randomized Controlled Trials as Topic; South Africa; Tenofovir; Vaginal Creams, Foams, and Jellies; Young Adult | 2010 |
Novel mutation in YMDD motif and direct neighbourhood in a child with chronic HBV-infection and clinical lamivudine and adefovir resistance - a scholarly case.
Topics: Adenine; Amino Acid Motifs; Amino Acid Sequence; Antiviral Agents; Child; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Molecular Sequence Data; Mutation, Missense; Organophosphonates; Sequence Alignment | 2010 |
Lamivudine plus adefovir or entecavir for patients with chronic hepatitis B resistant to lamivudine and adefovir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genes, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load | 2010 |
No changes in efavirenz plasma concentrations in HIV-infected patients who switch from Stocrin to Atripla.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Oxazines; Plasma | 2010 |
Lower arterial stiffness and Framingham score after switching abacavir to tenofovir in men at high cardiovascular risk.
Topics: Adenine; Cardiovascular Diseases; Dideoxynucleosides; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Assessment; Tenofovir; Vascular Resistance | 2010 |
High frequency of lamivudine resistance mutations in Brazilian patients co-infected with HIV and hepatitis B.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brazil; Comorbidity; Cross-Sectional Studies; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Male; Mutation; Organophosphonates; Tenofovir; Viral Core Proteins; Viral Load; Viral Proteins | 2010 |
Rescue therapy for lamivudine-resistant chronic hepatitis B: comparison between entecavir 1.0 mg monotherapy, adefovir monotherapy and adefovir add-on lamivudine combination therapy.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Republic of Korea; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2010 |
Associations of antiretroviral drug use and HIV-specific risk factors with carotid intima-media thickness.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Atherosclerosis; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Risk Factors; Tenofovir; Tunica Intima; Tunica Media | 2010 |
Tenofovir-linked hyperparathyroidism is independently associated with the presence of vitamin D deficiency.
Topics: Adenine; Adult; Female; HIV Infections; HIV-1; Humans; Hyperparathyroidism; Male; Middle Aged; Organophosphonates; Parathyroid Hormone; Tenofovir; United Kingdom; Urban Population; Vitamin D; Vitamin D Deficiency | 2010 |
Short communication: Inadequate vitamin D exacerbates parathyroid hormone elevations in tenofovir users.
Topics: Adenine; Adult; Anti-HIV Agents; Bone Density; Cross-Sectional Studies; Dose-Response Relationship, Drug; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Parathyroid Hormone; Tenofovir; Vitamin D; Vitamin D Deficiency | 2010 |
[Resistance mutation patterns of hepatitis B virus in patients with suboptimal response to adefovir dipivoxil therapy after lamivudine resistance].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates | 2010 |
Antiretroviral vaginal gel shows promise against HIV.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Retroviral Agents; Clinical Trials as Topic; Female; Gels; HIV Infections; HIV Seropositivity; Humans; Incidence; Infectious Disease Transmission, Vertical; Medication Adherence; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; South Africa; Tenofovir; Vagina | 2010 |
Can I tell you the truth? A comparative perspective on regulating off-label scientific and medical information.
Topics: Adenine; Angiogenesis Inhibitors; Anti-HIV Agents; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzhydryl Compounds; Bevacizumab; Botulinum Toxins, Type A; Central Nervous System Stimulants; Drug Industry; Ethics, Medical; Humans; Legislation, Drug; Modafinil; Neuromuscular Agents; Off-Label Use; Organophosphonates; Policy Making; Public Policy; Ranibizumab; Tenofovir; Treatment Outcome; Truth Disclosure; United Kingdom; United States; United States Food and Drug Administration | 2010 |
The curative efficiency of tenofovir for patients with chronic hepatitis B after failure of nucleoside/nucleotide analogues.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Nucleosides; Nucleotides; Organophosphonates; Remission Induction; Tenofovir; Treatment Failure | 2010 |
Evolution of drug resistance during 48 weeks of zidovudine/lamivudine/tenofovir in the absence of real-time viral load monitoring.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; Genotype; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Tenofovir; Time Factors; Viral Load; Zidovudine | 2010 |
Maraviroc concentrations in cerebrospinal fluid in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; CCR5 Receptor Antagonists; CD4 Lymphocyte Count; Chromatography, Liquid; Cyclohexanes; Didanosine; HIV Fusion Inhibitors; HIV Infections; HIV-1; Humans; Male; Maraviroc; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Tandem Mass Spectrometry; Tenofovir; Triazoles; Viral Load | 2010 |
After CAPRISA 004: time to re-evaluate the HIV lexicon.
Topics: Adenine; Administration, Intravaginal; Administration, Oral; Anti-HIV Agents; Female; Gels; HIV Infections; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2010 |
[A case of osteomalacia related to adefovir in a patient with chronic hepatitis B].
Topics: Adenine; Aged; Alkaline Phosphatase; Antiviral Agents; Dietary Supplements; DNA, Viral; Hepatitis B, Chronic; Humans; Hypophosphatemia; Liver Cirrhosis; Male; Organophosphonates; Osteomalacia; Phosphates; Whole Body Imaging | 2010 |
Tolerability of HIV postexposure prophylaxis with tenofovir/emtricitabine and lopinavir/ritonavir tablet formulation.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; CD4 Lymphocyte Count; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Post-Exposure Prophylaxis; Practice Guidelines as Topic; Pyrimidinones; Ritonavir; RNA, Viral; Tenofovir; Treatment Outcome; Young Adult | 2010 |
Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens.
Topics: Adaptation, Biological; Adenine; Adult; Amino Acid Substitution; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; pol Gene Products, Human Immunodeficiency Virus; RNA, Viral; Tenofovir | 2010 |
Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe.
Topics: Acetylation; Adenine; Arylamine N-Acetyltransferase; Fluorescent Dyes; Hep G2 Cells; Humans; Microscopy, Fluorescence; Naphthalimides; Organophosphonates; Sensitivity and Specificity; Spectrometry, Fluorescence | 2010 |
Functional hot spots in human ATP-binding cassette transporter nucleotide binding domains.
Topics: Adenine; Amino Acid Sequence; ATP-Binding Cassette Transporters; Binding Sites; Genetic Predisposition to Disease; HEK293 Cells; Humans; Models, Molecular; Molecular Sequence Annotation; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Organophosphonates; Polymorphism, Single Nucleotide; Protein Structure, Tertiary; Reproducibility of Results; Sequence Alignment; Tenofovir | 2010 |
Fate of the antiretroviral drug tenofovir in agricultural soil.
Topics: Adenine; Adsorption; Agriculture; Anti-Retroviral Agents; Environmental Monitoring; Kinetics; Organophosphonates; Soil; Soil Pollutants; Temperature; Tenofovir; Waste Disposal, Fluid | 2010 |
Management and treatment of chronic hepatitis B virus infection in HIV positive and negative patients: the EPIB 2008 study.
Topics: Adenine; Adult; Antiviral Agents; Female; France; Hepatitis B Antibodies; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Surveys and Questionnaires; Tenofovir | 2010 |
Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Biopsy; Drug Administration Schedule; Female; Glycosuria; HIV Infections; HIV-1; Humans; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Male; Microscopy, Electron; Middle Aged; Mitochondria; New York City; Organophosphonates; Proteinuria; Renal Dialysis; Renal Insufficiency; Retrospective Studies; Tenofovir; Time Factors | 2010 |
Trial results finally show potential for microbicidal HIV gel.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Female; Gels; HIV; HIV Infections; Humans; Organophosphonates; South Africa; Tenofovir; Vagina | 2010 |
Still a long wait for approved HIV-protective gel.
Topics: Adenine; Antiviral Agents; Deoxycytidine; Drug Approval; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Technology Transfer; Tenofovir; Vaginal Creams, Foams, and Jellies | 2010 |
Cost-utility analysis of tenofovir disoproxil fumarate in the treatment of chronic hepatitis B.
Topics: Adenine; Cost-Benefit Analysis; Guanine; Hepatitis B, Chronic; Humans; Markov Chains; Organophosphonates; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; State Medicine; Tenofovir; United Kingdom | 2010 |
Low bone mineral density with tenofovir: does statistically significant mean clinically significant?
Topics: Adenine; Adult; Anti-HIV Agents; Bone Density; Bone Diseases; Female; Fractures, Bone; HIV Infections; Humans; Incidence; Male; Organophosphonates; Tenofovir | 2010 |
[Two cases of Fanconi's syndrome induced by tenofovir in the Ivory Coast].
Topics: Adenine; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cote d'Ivoire; Cyclopropanes; Drug Therapy, Combination; Enterobacter aerogenes; Enterobacteriaceae Infections; Fanconi Syndrome; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lopinavir; Malaria; Male; Middle Aged; Organophosphonates; Pyelonephritis; Pyrimidinones; Ritonavir; Tenofovir | 2011 |
Antiviral treatment including entecavir plus tenofovir disoproxil fumarate for HBV reactivation following a rituximab-based regimen.
Topics: Adenine; Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Drug Combinations; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lymphoma, Non-Hodgkin; Middle Aged; Organophosphonates; Rituximab; Tenofovir; Virus Activation | 2010 |
HBcrAg is a predictor of post-treatment recurrence of hepatocellular carcinoma during antiviral therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Catheter Ablation; Disease-Free Survival; Female; Guanine; Hepatectomy; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Japan; Kaplan-Meier Estimate; Lamivudine; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Organophosphonates; Proportional Hazards Models; Risk Assessment; Risk Factors; RNA, Viral; Survival Rate; Time Factors; Treatment Outcome | 2010 |
[Antiviral treatment of chronic B hepatitis; 2010 - therapeutic recommendations].
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Liver; Organophosphonates; Polyethylene Glycols; Practice Guidelines as Topic; Recombinant Proteins; Tenofovir; Treatment Failure; Viral Load | 2010 |
[Treatment of chronic hepatitis B. High response rate in general practice].
Topics: Adenine; Antiviral Agents; Cross-Sectional Studies; Germany; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Long-Term Care; Organophosphonates; Patient Care Team; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2010 |
Preventing HIV infection: turning the tide for young women.
Topics: Adenine; Adolescent; Africa South of the Sahara; Antiviral Agents; Female; HIV Infections; HIV-1; Humans; Motivation; Naphthalenesulfonates; Organophosphonates; Polymers; Tenofovir; Vaginal Creams, Foams, and Jellies; Young Adult | 2010 |
Changes in the renal function after tenofovir-containing antiretroviral therapy initiation in a Senegalese cohort (ANRS 1215).
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Incidence; Kidney; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Senegal; Tenofovir | 2010 |
The impact of gender and anchor drugs on TDF renal toxicity.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Lamivudine; Male; Organophosphonates; Sex Factors; Tenofovir | 2010 |
A tailored dose of tenofovir could reduce its impact on bone mass in HIV Type 1-infected children and adolescents: a report from 5 years of clinical experience.
Topics: Adenine; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone and Bones; Calcification, Physiologic; Child; Child, Preschool; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Tenofovir | 2010 |
Hepatitis B virus reverse transcriptase sequence variant database for sequence analysis and mutation discovery.
Topics: Adenine; Base Sequence; Databases, Genetic; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Genetic Association Studies; Genetic Variation; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Molecular Sequence Data; Multilocus Sequence Typing; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 2010 |
Hepatitis B virus (HBV) subgenotypes C2 and B2 differ in lamivudine- and adefovir-resistance-associated mutational patterns in HBV-infected Chinese patients.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Asian People; China; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Prevalence; Young Adult | 2010 |
Impact of hepatitis B e antigen-suppressing mutations on the replication efficiency of entecavir-resistant hepatitis B virus strains.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Viral; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Polymorphism, Single Nucleotide; Tenofovir; Viral Load; Viral Proteins; Virus Replication | 2011 |
Persistence and adherence to nucleos(t)ide analogue treatment for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Cohort Studies; Drug Resistance, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Medication Adherence; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Young Adult | 2011 |
Treatment of children with chronic hepatitis B virus infection in the United States: patient selection and therapeutic options.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Child; Child, Preschool; DNA, Viral; Drug Resistance, Viral; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Interferon alpha-2; Interferon-alpha; Lamivudine; Organophosphonates; Patient Selection; Recombinant Proteins | 2010 |
In vitro evaluation of viability, integrity, and inflammation in genital epithelia upon exposure to pharmaceutical excipients and candidate microbicides.
Topics: Adenine; Anilides; Anti-Infective Agents; Benzofurans; Cell Line; Cell Survival; Cervix Uteri; Epithelium; Female; Furans; HIV Infections; Humans; In Vitro Techniques; Interleukin-8; Laurates; Monoglycerides; Naphthalenesulfonates; Organophosphonates; Polymers; Reverse Transcriptase Inhibitors; Tenofovir; Thioamides | 2010 |
Enhancing the antihepatitis B virus immune response by adefovir dipivoxil and entecavir therapies.
Topics: Adenine; Administration, Oral; Adult; Antiviral Agents; Case-Control Studies; Cytokines; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunomodulation; Lamivudine; Male; Middle Aged; Organophosphonates; T-Lymphocytes, Regulatory; Th1-Th2 Balance | 2011 |
Initial virological response and viral mutation with adefovir dipivoxil added to ongoing Lamivudine therapy in Lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome | 2011 |
Serine side chain-linked peptidomimetic conjugates of cyclic HPMPC and HPMPA: synthesis and interaction with hPEPT1.
Topics: Adenine; Cytosine; Dipeptides; Humans; Molecular Structure; Organophosphonates; Organophosphorus Compounds; Peptide Transporter 1; Prodrugs; Serine; Stereoisomerism; Symporters | 2010 |
Tenofovir (TDF)-selected or abacavir (ABC)-selected low-frequency HIV type 1 subpopulations during failure with persistent viremia as detected by ultradeep pyrosequencing.
Topics: Adenine; Dideoxynucleosides; HIV-1; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Viremia | 2011 |
Three-year efficacy and safety of tenofovir disoproxil fumarate treatment for chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Biopsy; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir; Treatment Outcome; Virus Replication; Young Adult | 2011 |
High rate of adefovir-lamivudine combination therapy in nucleoside-naïve patients with chronic hepatitis B in France: results of a national survey in 1730 patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Cross-Sectional Studies; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Drug Utilization; Female; France; Health Care Surveys; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Practice Patterns, Physicians'; Registries; Retrospective Studies; Treatment Outcome; Viral Load; Young Adult | 2010 |
Implications of HIV PrEP trials results.
Topics: Adenine; Anti-HIV Agents; Chemoprevention; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir; Treatment Outcome; United States | 2011 |
Efficacy and safety of entecavir and/or tenofovir for prophylaxis and treatment of hepatitis B recurrence post-liver transplant.
Topics: Adenine; Adult; Aged; Antiviral Agents; Combined Modality Therapy; Female; Guanine; Hepatitis B; Humans; Liver Transplantation; Male; Middle Aged; Organophosphonates; Secondary Prevention; Tenofovir | 2010 |
Prevention. Study reveals that vaginal gel reduces HIV, herpes.
Topics: Adenine; Female; Gels; Herpes Genitalis; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Vagina | 2010 |
Virologic and clinical outcomes in HIV/HBV coinfected patients on tenofovir-containing HAART.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Hepatitis B, Chronic; HIV Infections; Humans; Organophosphonates; Tenofovir | 2010 |
Efficacy and pharmacokinetics of adefovir dipivoxil liquid suspension in patients with chronic hepatitis B and renal impairment.
Topics: Adenine; Adult; Aged; Antiviral Agents; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Pharmaceutical Solutions; Renal Insufficiency; Treatment Outcome | 2011 |
[Human immunodeficiency virus and Chagas disease coinfection treated successfully with benznidazole and a raltegravir-based antiretroviral regimen: a case report].
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Chagas Disease; Drug Interactions; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Nitroimidazoles; Oligopeptides; Organophosphonates; Paraguay; Pyridines; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Spain; Tenofovir; Trypanocidal Agents; Zidovudine | 2011 |
Liver fibrosis changes in HIV-HBV-coinfected patients: clinical, biochemical and histological effect of long-term tenofovir disoproxil fumarate use.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; DNA, Viral; Female; Hepacivirus; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C; Hepatitis D, Chronic; HIV Infections; Humans; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Load | 2010 |
Occult HBV infection in untreated HIV-infected adults in Côte d'Ivoire.
Topics: Adenine; Adult; Aged; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cote d'Ivoire; Cross-Sectional Studies; Deoxycytidine; DNA, Viral; Emtricitabine; Female; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prevalence; Tenofovir; World Health Organization; Young Adult | 2010 |
Tenofovir disoproxil fumarate and bone mineral density: a 60-month longitudinal study in a cohort of HIV-infected youths.
Topics: Adenine; Adolescent; Antiretroviral Therapy, Highly Active; Biomarkers; Bone Density; Child; Child, Preschool; Collagen Type I; Female; Follow-Up Studies; HIV; HIV Infections; Humans; Longitudinal Studies; Male; Organophosphonates; Peptides; Tenofovir; Young Adult | 2010 |
High prevalence of and progression to low bone mineral density in HIV-infected patients: a longitudinal cohort study.
Topics: Absorptiometry, Photon; Adenine; Aged; Antiretroviral Therapy, Highly Active; Bone Density; Cohort Studies; Cross-Sectional Studies; Disease Progression; Female; HIV Infections; Humans; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Osteoporosis; Prevalence; Radionuclide Imaging; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir | 2010 |
A single tablet regimen is associated with higher adherence and viral suppression than multiple tablet regimens in HIV+ homeless and marginally housed people.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Ill-Housed Persons; Male; Middle Aged; Organophosphonates; Patient Compliance; Tenofovir; Viral Load | 2010 |
[Immune reconstitution inflammatory syndrome associated with eosinophilic pustular folliculitis in an HIV-infected patient].
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Diagnosis, Differential; Emtricitabine; Eosinophilia; Folliculitis; HIV Infections; Humans; Immune Reconstitution Inflammatory Syndrome; Organophosphonates; Rosacea; Skin Diseases, Infectious; Tenofovir | 2011 |
Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus (J Viral Hepat 2010 Feb 1;17(2):123-9).
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B virus; Humans; Kidney; Male; Organophosphonates; Renal Insufficiency | 2011 |
The role of nucleoside and nucleotide analogues in nodular regenerative hyperplasia in HIV-infected patients: a case control study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Case-Control Studies; Didanosine; Female; HIV Infections; Humans; Hyperplasia; Hypertension, Portal; Liver; Liver Regeneration; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Tenofovir | 2011 |
Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity.
Topics: Adenine; Anti-HIV Agents; Cell Line; HeLa Cells; HIV-1; Humans; Integrase Inhibitors; Organophosphonates; Pyrrolidinones; Quinolones; Raltegravir Potassium; Tenofovir; Zidovudine | 2011 |
Incidence and risk factors for tenofovir-associated renal function decline among Thai HIV-infected patients with low-body weight.
Topics: Adenine; Adult; Anti-HIV Agents; Body Mass Index; Body Weight; Cohort Studies; Drug Interactions; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Incidence; Kaplan-Meier Estimate; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Retrospective Studies; Risk Factors; Tenofovir; Thailand | 2010 |
B1, a novel amonafide analogue, overcomes the resistance conferred by Bcl-2 in human promyelocytic leukemia HL60 cells.
Topics: 14-3-3 Proteins; Adenine; Antineoplastic Agents; Apoptosis; Benzothiazoles; Cell Line, Tumor; DNA-Binding Proteins; Down-Regulation; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Genes, bcl-2; Genes, MDR; Genes, p53; HL-60 Cells; Humans; K562 Cells; Leukemia, Promyelocytic, Acute; Naphthalimides; Organophosphonates; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; U937 Cells | 2010 |
Prospective study of renal function in HIV-infected pediatric patients receiving tenofovir-containing HAART regimens.
Topics: Adenine; Adolescent; Antiretroviral Therapy, Highly Active; Child; Female; HIV Infections; Humans; Kidney Diseases; Kidney Function Tests; Male; Organophosphonates; Prospective Studies; Proteinuria; Spain; Tenofovir | 2011 |
Tenofovir-induced kidney disease: an acquired renal tubular mitochondriopathy.
Topics: Acute Kidney Injury; Adenine; Animals; Anti-HIV Agents; Drug Administration Schedule; Glycosuria; HIV Infections; HIV-1; Humans; Kidney Tubular Necrosis, Acute; Kidney Tubules, Proximal; Mitochondria; Organophosphonates; Proteinuria; Renal Dialysis; Renal Insufficiency; Tenofovir; Time Factors | 2010 |
Raltegravir is a substrate for SLC22A6: a putative mechanism for the interaction between raltegravir and tenofovir.
Topics: Adenine; Animals; Anti-HIV Agents; Biological Transport; Caco-2 Cells; Cell Line; Drug Interactions; HIV Integrase Inhibitors; Humans; Kidney; Leukocytes, Mononuclear; Oocytes; Organic Anion Transport Protein 1; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Substrate Specificity; Tenofovir; Xenopus laevis | 2011 |
Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases.
Topics: Adenine; Anti-HIV Agents; DNA-Directed DNA Polymerase; Humans; Lamivudine; Molecular Structure; Organophosphonates; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tenofovir; Zidovudine | 2011 |
Entecavir as treatment for reactivation of hepatitis B in immunosuppressed patients.
Topics: Adenine; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunocompromised Host; Immunosuppressive Agents; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome | 2010 |
Oral preexposure prophylaxis for HIV--another arrow in the quiver?
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Patient Compliance; Tenofovir | 2010 |
[Analogs combination therapy in chronic hepatitis B: when and how?].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2010 |
[Long-term therapy for chronic hepatitis B in HIV co-infected patients].
Topics: Adenine; Antiretroviral Therapy, Highly Active; Antiviral Agents; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B, Chronic; HIV Infections; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine | 2010 |
[Treatment has a positive impact on the long-term evolution of chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Clinical Trials as Topic; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2010 |
Th1 and Th2 immune response in chronic hepatitis B patients during a long-term treatment with adefovir dipivoxil.
Topics: Adenine; Adult; Antiviral Agents; Clinical Trials as Topic; Cytokines; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Th1 Cells; Th2 Cells | 2010 |
Lipid-lowering effect of tenofovir in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Anticholesteremic Agents; Female; HIV Infections; Humans; Lipids; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2011 |
First real success for anti-HIV gel: a new start for HIV microbicides?
Topics: Adenine; Adolescent; Adult; Anti-Infective Agents; Controlled Clinical Trials as Topic; Disease Transmission, Infectious; Female; HIV Infections; Humans; Organophosphonates; Sexually Transmitted Diseases, Viral; South Africa; Tenofovir; Treatment Outcome; Vaginal Creams, Foams, and Jellies; Young Adult | 2010 |
Characteristics of adefovir resistance in patients with or without lamivudine-resistant hepatitis B virus treated with adefovir: a 4-year experience.
Topics: Adenine; Adult; Aged; Antiviral Agents; Base Sequence; Cloning, Molecular; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Sequence Analysis, DNA; Time Factors | 2011 |
Profile of HBV antiviral resistance mutations with distinct evolutionary pathways against nucleoside/nucleotide analogue treatment among Chinese chronic hepatitis B patients.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; China; Cross-Sectional Studies; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Typing; Mutation, Missense; Nucleosides; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine; Young Adult | 2010 |
Evolution and suppression of HBV strains with multidrug resistance to lamivudine, adefovir dipivoxil and entecavir in a patient with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Evolution, Molecular; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Lamivudine; Male; Organophosphonates; Phylogeny; Recombinant Proteins; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome | 2010 |
No impact of oral tenofovir disoproxil fumarate on herpes simplex virus shedding in HIV-infected adults.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Canada; Female; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Virus Shedding | 2011 |
Tenofovir for treatment of hepatitis B virus reactivation in patients with chronic GVHD.
Topics: Adenine; Adult; Chronic Disease; Female; Graft vs Host Disease; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Virus Activation | 2011 |
Prevention of lamivudine-resistant hepatitis B recurrence after liver transplantation with entecavir plus tenofovir combination therapy and perioperative hepatitis B immunoglobulin only.
Topics: Adenine; Antiviral Agents; Combined Modality Therapy; Drug Resistance, Viral; Guanine; Hepatitis B; Hepatitis B virus; Humans; Immunization, Passive; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Perioperative Care; Secondary Prevention; Tenofovir; Treatment Outcome | 2011 |
Implementing a tenofovir-based first-line regimen in rural Lesotho: clinical outcomes and toxicities after two years.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Female; HIV Infections; Humans; Lesotho; Male; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Rural Population; Tenofovir; Treatment Outcome | 2011 |
Concentrations of tenofovir and emtricitabine in breast milk of HIV-1-infected women in Abidjan, Cote d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2.
Topics: Adenine; Anti-HIV Agents; Cote d'Ivoire; Deoxycytidine; Emtricitabine; Female; Humans; Infant, Newborn; Milk, Human; Organophosphonates; Tenofovir | 2011 |
Normal plasma FGF23 levels kinetic in tenofovir-related hypophosphatemic osteomalacia in an HIV-infected patient with von Recklinghausen disease.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Drug Substitution; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Humans; Hypophosphatemia; Male; Neurofibromatosis 1; Organophosphonates; Osteomalacia; Phosphates; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Treatment Outcome | 2011 |
Avascular necrosis of the talus in a HIV-infected patient.
Topics: Adenine; Carbamates; Deoxycytidine; Emtricitabine; Furans; HIV Infections; HIV Protease Inhibitors; Humans; Immunocompromised Host; Male; Middle Aged; Organophosphates; Organophosphonates; Orthotic Devices; Osteonecrosis; Reverse Transcriptase Inhibitors; Ritonavir; Sulfonamides; Talus; Tenofovir | 2010 |
Pharmacokinetics and efficacy of intravenous or intramuscular hepatitis B immunoglobulins in prophylaxis of hepatitis B after liver transplantation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Administration Schedule; Female; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Injections, Intramuscular; Injections, Intravenous; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prohibitins; Prospective Studies; Reverse Transcriptase Inhibitors; Secondary Prevention | 2010 |
Treatment of HBeAg-negative chronic hepatitis B patients with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine; Time Factors; Treatment Outcome | 2011 |
Tenofovir salvage for nucleoside experienced patients: muddy waters?
Topics: Adenine; Drug Resistance, Viral; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors; Salvage Therapy; Tenofovir | 2011 |
Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.
Topics: Adenine; Adrenergic beta-1 Receptor Agonists; Animals; Antigens, Bacterial; Bacterial Toxins; Cyclic AMP; Dobutamine; Heart; Heart Rate; Male; Myocardium; Organophosphonates; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2011 |
The ART of preventing HIV.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Retroviral Agents; Circumcision, Male; Deoxycytidine; Emtricitabine; Female; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Random Allocation; Risk Assessment; Tenofovir | 2011 |
The level of HBV DNA at month 12 is an important predictor of virological breakthrough during adefovir monotherapy in chronic hepatitis B patients with lamivudine resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Treatment Outcome | 2011 |
Hyperlipidemic acute pancreatitis: a possible role of antiretroviral therapy with entecavir.
Topics: Abdominal Pain; Acute Disease; Adenine; Adult; Alcoholism; Antiretroviral Therapy, Highly Active; Critical Care; Diabetes Mellitus, Type 2; Fever; Guanine; Hepatitis B, Chronic; Humans; Hyperlipidemias; Hypertriglyceridemia; Male; Organophosphonates; Pancreatitis; Plasmapheresis; Reverse Transcriptase Inhibitors; Tenofovir; Tomography, X-Ray Computed; Triglycerides | 2011 |
Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6).
Topics: Adenine; Antiviral Agents; Cell Line; Chromatography, High Pressure Liquid; Flavonoids; Humans; Kinetics; Organic Anion Transport Protein 1; Organophosphonates | 2011 |
Microbicides & their implications in HIV prevention.
Topics: Adenine; Anti-HIV Agents; Anti-Infective Agents; Clinical Trials as Topic; Female; HIV Infections; Humans; India; Organophosphonates; Risk Factors; Sex Factors; Tenofovir | 2010 |
HIV-2 goes global: an unaddressed issue in Indian anti-retroviral programmes.
Topics: Adenine; Anti-HIV Agents; HIV Infections; HIV-2; Humans; India; Organophosphonates; Prevalence; Tenofovir; Zidovudine | 2010 |
AIDS: Drugs that prevent HIV infection.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Administration, Intravaginal; Administration, Oral; Animals; Anti-HIV Agents; Condoms; Controlled Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; Homosexuality, Male; Humans; Male; Medication Adherence; Organophosphonates; Placebos; Reverse Transcriptase Inhibitors; Safe Sex; Tenofovir; Vaginal Creams, Foams, and Jellies | 2011 |
K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism.
Topics: Adenine; Catalytic Domain; Computer Simulation; Drug Resistance, Viral; HIV; HIV Reverse Transcriptase; Humans; Hydrogen Bonding; Kinetics; Mutation, Missense; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
HIV prevention in women: next steps.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Clinical Trials, Phase III as Topic; Coitus; Female; HIV Infections; Humans; Organophosphonates; Tenofovir; Vaginal Creams, Foams, and Jellies | 2011 |
Add-on adefovir is superior to a switch to entecavir as rescue therapy for Lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load | 2011 |
Cost effectiveness of atazanavir-ritonavir versus lopinavir-ritonavir in treatment-naïve human immunodeficiency virus-infected patients in the United States.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Cost-Benefit Analysis; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Markov Chains; Oligopeptides; Organophosphonates; Pyridines; Pyrimidinones; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Risk Assessment; Ritonavir; Tenofovir; United States | 2011 |
Lactic acidosis after concomitant treatment with metformin and tenofovir in a patient with HIV infection.
Topics: Acidosis, Lactic; Acute Kidney Injury; Adenine; Aged; Anti-HIV Agents; Diabetes Mellitus, Type 2; Drug Interactions; HIV Infections; Humans; Hypoglycemic Agents; Male; Metformin; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
[Tenofovir, an antiviral agent with low spermiostatic activity].
Topics: Adenine; Anti-HIV Agents; Humans; Male; Organophosphonates; Sperm Motility; Tenofovir | 2011 |
Circulating Tregs correlate with viral load reduction in chronic HBV-treated patients with tenofovir disoproxil fumarate.
Topics: Adenine; Adult; Antigens, CD; Case-Control Studies; CD8-Positive T-Lymphocytes; DNA, Viral; Female; Flow Cytometry; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunoassay; Male; Middle Aged; Organophosphonates; Programmed Cell Death 1 Receptor; T-Lymphocytes, Regulatory; Tenofovir; Viral Load | 2011 |
[Efficacy of entecavir and adefovir combination therapy in patients with chronic hepatitis B refractory to lamivudine and adefovir combination therapy].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2011 |
[Efficacy and treatment strategy for drug resistances of nucleos(t)ide analogues for chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir | 2011 |
7-b, a novel amonafide analogue, cause growth inhibition and apoptosis in Raji cells via a ROS-mediated mitochondrial pathway.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Burkitt Lymphoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Drug Evaluation, Preclinical; Humans; Mitochondria; Models, Biological; Naphthalimides; Necrosis; Organophosphonates; Reactive Oxygen Species; Signal Transduction | 2011 |
HBV core region variability: effect of antiviral treatments on main epitopic regions.
Topics: Adenine; Adult; Amino Acid Sequence; Antigenic Variation; Antiviral Agents; B-Lymphocytes; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B Core Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunodominant Epitopes; Interferons; Lamivudine; Male; Middle Aged; Molecular Sequence Data; Mutation; Organophosphonates; Polymorphism, Genetic; T-Lymphocytes | 2011 |
Analysis of drug resistance during HIV RNA viraemia in the MONET trial of darunavir/ritonavir monotherapy.
Topics: Adenine; Adult; Anti-HIV Agents; Clinical Trials as Topic; Darunavir; Deoxycytidine; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Male; Molecular Typing; Mutation; Organophosphonates; Ritonavir; RNA, Viral; Sulfonamides; Tenofovir; Treatment Outcome; Virus Replication | 2011 |
Comparison of multiplex restriction fragment mass polymorphism and sequencing analyses for detecting entecavir resistance in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mass Spectrometry; Mutation; Organophosphonates; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Sequence Analysis, DNA; Viral Load | 2011 |
Is tenofovir-related renal toxicity incompletely reversible?
Topics: Adenine; Adult; Anti-HIV Agents; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Tenofovir | 2011 |
Defining virologic relapse in chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Recurrence; Retrospective Studies; Treatment Outcome; Viral Load | 2011 |
Does the antiviral therapy of patients with chronic hepatitis exert nephrotoxic effects?
Topics: Adenine; Adult; Albuminuria; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Ribavirin; Time Factors | 2011 |
Management of chronic hepatitis B patients: efficacy & limitation of nucleos(t)ide analogues.
Topics: Adenine; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Pilot Projects; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Virus Replication | 2011 |
Tenofovir therapy in hepatitis B virus-positive solid-organ transplant recipients.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biomarkers; DNA, Viral; Drug Therapy, Combination; Enzymes; Female; France; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Lamivudine; Male; Middle Aged; Organ Transplantation; Organophosphonates; Pilot Projects; Tenofovir; Time Factors; Treatment Outcome; Viral Load | 2011 |
Medication nonadherence with long-term management of patients with hepatitis B e antigen-negative chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Cohort Studies; Community Health Services; Drug Resistance, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Medication Adherence; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load | 2011 |
Generation and mucosal transmissibility of emtricitabine- and tenofovir-resistant SHIV162P3 mutants in macaques.
Topics: Adenine; Animals; Anti-HIV Agents; Deoxycytidine; Disease Models, Animal; Drug Resistance, Viral; Emtricitabine; HIV; Humans; Macaca; Mutation; Organophosphonates; Recombination, Genetic; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Virus Cultivation | 2011 |
[Virological response to adefovir dipivoxil predicts the long-term development of resistance in previously untreated patients with HBeAg-negative chronic hepatitis B].
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prognosis; Retrospective Studies; Time Factors; Young Adult | 2011 |
[HIV infected women with intense bone and muscular pain and general weakness].
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Fanconi Syndrome; Female; Hepatitis, Viral, Human; HIV Infections; Humans; Hypophosphatemia; Middle Aged; Muscle Weakness; Musculoskeletal Diseases; Organophosphonates; Osteomalacia; Pain; Radionuclide Imaging; Radiopharmaceuticals; Substance Abuse, Intravenous; Technetium Tc 99m Medronate; Tenofovir | 2011 |
HIV-2 infection, end-stage renal disease and protease inhibitor intolerance: which salvage regimen?
Topics: Adenine; Adult; Anti-HIV Agents; Drug Therapy, Combination; HIV Infections; HIV-2; Humans; Kidney Failure, Chronic; Lamivudine; Male; Organophosphonates; Protease Inhibitors; Pyrrolidinones; Raltegravir Potassium; Renal Dialysis; Salvage Therapy; Tenofovir; Treatment Outcome | 2011 |
Managing hepatitis B/HIV co-infected: adding entecavir to truvada (tenofovir disoproxil/emtricitabine) experienced patients.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Deoxycytidine; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2011 |
[Design, synthesis and anti-hBV evaluation of adefovir mono-L-amino acid ester, mono non-steroidal anti-inflammatory drugs carboxylic ester prodrugs].
Topics: Adenine; Amino Acids; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Carboxylic Acids; Cell Survival; Drug Design; Hep G2 Cells; Humans; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Molecular Structure; Organophosphonates; Prodrugs | 2010 |
Analysis of resistance testing in South Trinidad.
Topics: Adenine; Anti-HIV Agents; Darunavir; Drug Resistance, Multiple; Drug Resistance, Viral; HIV Infections; HIV Protease Inhibitors; Humans; Mutation; Organophosphonates; Patient Compliance; Sulfonamides; Tenofovir; Trinidad and Tobago | 2010 |
Proper antiviral therapy for hepatitis B virus-associated acute-on-chronic liver failure.
Topics: Adenine; Antiviral Agents; End Stage Liver Disease; Guanine; Hepatitis B, Chronic; Humans; Liver Failure, Acute; Organophosphonates; Tenofovir | 2011 |
Adefovir-induced Stevens-Johnson syndrome and toxic epidermal necrolysis overlap syndrome.
Topics: Adenine; Antiviral Agents; Biopsy; Epidermis; Follow-Up Studies; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Male; Middle Aged; Organophosphonates; Photomicrography; Stevens-Johnson Syndrome | 2011 |
Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation, Missense; Nucleosides; Organophosphonates; Pyrimidinones; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Telbivudine; Thymidine; Viral Proteins | 2011 |
Low incidence of renal impairment observed in tenofovir-treated patients.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Case-Control Studies; Cohort Studies; Female; HIV Infections; Humans; Incidence; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Retrospective Studies; Risk Factors; Tenofovir | 2011 |
Microbial biofilms on the surface of intravaginal rings worn in non-human primates.
Topics: Adenine; Animals; Anti-HIV Agents; Bacteria; Biodiversity; Biofilms; Contraceptive Devices, Female; Delayed-Action Preparations; Female; In Situ Hybridization, Fluorescence; Macaca nemestrina; Microscopy, Confocal; Microscopy, Electron, Scanning; Organophosphonates; Tenofovir | 2011 |
Determination of the antiretroviral drug tenofovir in plasma from HIV-infected adults by ultrafast isotope dilution MALDI-triple quadrupole tandem mass spectrometry.
Topics: Adenine; Adult; Anti-HIV Agents; HIV Infections; Humans; Isotope Labeling; Linear Models; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Tenofovir; Triglycerides | 2011 |
[HIV and AIDS: what's new in 2010?].
Topics: Adenine; Anti-HIV Agents; Anti-Retroviral Agents; Chemoprevention; Gels; HIV Infections; Humans; Organophosphonates; Tenofovir | 2011 |
Enhanced dissolution and stability of adefovir dipivoxil by cocrystal formation.
Topics: Adenine; Chemistry, Pharmaceutical; Crystallization; Drug Stability; Organophosphonates; Saccharin; Solubility | 2011 |
Tenofovir renal proximal tubular toxicity is regulated by OAT1 and MRP4 transporters.
Topics: Adenine; Analysis of Variance; Animals; DNA, Mitochondrial; Kidney Tubules, Proximal; Lasers; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdissection; Mitochondria; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction; Tenofovir | 2011 |
Renal safety of a tenofovir-containing first line regimen: experience from an antiretroviral cohort in rural Lesotho.
Topics: Adenine; Adult; Algorithms; Anti-Retroviral Agents; Cohort Studies; Creatinine; Female; Follow-Up Studies; Humans; Kidney; Kidney Function Tests; Lesotho; Male; Organophosphonates; Program Evaluation; Risk Factors; Rural Population; Tenofovir | 2011 |
[Renal adverse reactions of antiretroviral medication: proximal tubular dysfunction associated with tenofovir].
Topics: Adenine; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2011 |
Synthesis and antiviral activity of N9-[3-fluoro-2-(phosphonomethoxy)propyl] analogues derived from N6-substituted adenines and 2,6-diaminopurines.
Topics: 2-Aminopurine; 3T3 Cells; Adenine; Animals; Antiviral Agents; Cells, Cultured; Crystallography, X-Ray; Dose-Response Relationship, Drug; HIV-1; HIV-2; Humans; Mice; Mice, Inbred C3H; Moloney murine sarcoma virus; Organophosphonates; Purines; Structure-Activity Relationship | 2011 |
Formulation of tenofovir-loaded functionalized solid lipid nanoparticles intended for HIV prevention.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Cell Culture Techniques; Cell Line; Cell Survival; Chemistry, Pharmaceutical; Drug Carriers; Epithelial Cells; Female; Heparin; HIV Infections; Humans; Lipids; Microscopy, Electron, Transmission; Nanoparticles; Organophosphonates; Particle Size; Phase Transition; Polylysine; Surface Properties; Tenofovir; Vagina | 2011 |
Low liver stiffness among cirrhotic patients with hepatitis B after prolonged treatment with nucleoside analogs.
Topics: Adenine; Adult; Elasticity Imaging Techniques; Female; Hepatitis B; Humans; Lamivudine; Liver; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors | 2011 |
Hypophosphatemic osteomalacia as a long-term complication after liver transplantation.
Topics: Adenine; Aged; Fanconi Syndrome; Female; Humans; Hypophosphatemia; Immunosuppressive Agents; Liver Transplantation; Male; Middle Aged; Organophosphonates; Osteomalacia; Pain; Phosphates; Quality of Life; Treatment Outcome; Vitamin D | 2011 |
On-treatment monitoring of liver fibrosis with transient elastography in chronic hepatitis B patients.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Biopsy; Disease Progression; Elasticity Imaging Techniques; Female; Hepatitis B, Chronic; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Severity of Illness Index; Treatment Outcome; Young Adult | 2011 |
Six-year follow-up of hepatitis B surface antigen concentrations in tenofovir disoproxil fumarate treated HIV-HBV-coinfected patients.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Young Adult | 2011 |
Outcome of patients suffering from a spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure and treated with antivirals.
Topics: Adenine; Antiviral Agents; DNA, Viral; Female; Hepatitis B, Chronic; Humans; Liver Failure, Acute; Male; Organophosphonates | 2011 |
Tenofovir-induced renal toxicity in 324 HIV-infected, antiretroviral-naïve patients.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Tenofovir | 2011 |
Modeling of autocatalytic hydrolysis of adefovir dipivoxil in solid formulations.
Topics: Adenine; Catalysis; Chemistry, Pharmaceutical; Dosage Forms; Drug Stability; Hydrolysis; Neural Networks, Computer; Organophosphonates; Prodrugs | 2011 |
Preexposure chemoprophylaxis for HIV prevention.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Risk-Taking; Sexual Behavior; Tenofovir | 2011 |
Preexposure chemoprophylaxis for HIV prevention.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Risk-Taking; Sexual Behavior; Tenofovir | 2011 |
Preexposure chemoprophylaxis for HIV prevention.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Tenofovir | 2011 |
Preexposure chemoprophylaxis for HIV prevention.
Topics: Adenine; Age Factors; Anti-HIV Agents; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Kaplan-Meier Estimate; Male; Organophosphonates; Tenofovir; Young Adult | 2011 |
Preexposure chemoprophylaxis for HIV prevention.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Costs; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Risk; Tenofovir | 2011 |
Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12/IL-10 balance in human primary cells.
Topics: Adenine; Anti-HIV Agents; Cell Line; Chemokine CCL3; Gene Expression Regulation; Humans; Interleukin-10; Interleukin-12; Interleukin-8; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Organophosphonates; Tenofovir; Toll-Like Receptors; Tumor Necrosis Factor-alpha; Zidovudine | 2011 |
Cystatin C and baseline renal function among HIV-infected persons in the SUN Study.
Topics: Adenine; Adult; Anti-HIV Agents; Body Mass Index; CD4 Lymphocyte Count; Cohort Studies; Cross-Sectional Studies; Cystatin C; Female; Glomerular Filtration Rate; Hepatitis C; HIV Seropositivity; Humans; Hypertension; Male; Organophosphonates; Prospective Studies; Renal Insufficiency; Ritonavir; Tenofovir | 2012 |
[The replication capacity and drug sensitivity of Adefovir dipivoxil-resistant HBV mutants in vivo].
Topics: Adenine; Animals; Antiviral Agents; Base Sequence; Drug Resistance, Viral; Hepatitis B; Hepatitis B virus; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Organophosphonates | 2011 |
Long-term add-on therapy with adefovir in lamivudine-resistant kidney graft recipients with chronic hepatitis B.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Survival Rate; Time Factors; Treatment Outcome | 2011 |
Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection.
Topics: Acute Disease; Adenine; Adolescent; Adult; Aged; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2011 |
Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine.
Topics: Adenine; Animals; Antiviral Agents; Cidofovir; Cowpox virus; Cytosine; Ectromelia virus; Esters; Guinea Pigs; Haplorhini; Humans; Liver; Organophosphonates; Rats; Vaccinia virus | 2011 |
Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).
Topics: Adenine; Anti-HIV Agents; Cell Line; Drug Synergism; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Organophosphonates; Tenofovir | 2011 |
Clinical course and predictive factors of virological response in long-term lamivudine plus adefovir dipivoxil combination therapy for lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Aged; Amino Acid Substitution; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Gene Products, pol; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Japan; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Prognosis; Reverse Transcriptase Inhibitors; Treatment Outcome; Viral Load; Young Adult | 2011 |
Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Child; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Humans; Lamivudine; Luminescent Measurements; Male; Middle Aged; Mutagenesis, Site-Directed; Mutation; Organophosphonates; Polymerase Chain Reaction; Protein Array Analysis; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase | 2011 |
Clinical experience with nevirapine combined with tenofovir plus emtricitabine or lamivudine-containing regimens in HIV-infected subjects.
Topics: Adenine; Adult; Anti-HIV Agents; Australia; Deoxycytidine; Drug Administration Schedule; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Lost to Follow-Up; Male; Medical Audit; Middle Aged; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2011 |
Cardiovascular risks associated with abacavir and tenofovir exposure in HIV-infected persons.
Topics: Adenine; Anti-Retroviral Agents; Biomarkers, Pharmacological; Cardiovascular Diseases; CD4 Lymphocyte Count; Cohort Studies; Dideoxynucleosides; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Risk Factors; Tenofovir; United States; Veterans; Viral Load | 2011 |
Improvement in chronic renal impairment following the discontinuation of tenofovir in two HIV-infected patients.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biomarkers; Biopsy; Chronic Disease; Creatinine; Drug Substitution; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors.
Topics: Adenine; Animals; Anti-HIV Agents; Chemoprevention; Deoxyadenine Nucleotides; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lymphocytes; Lymphoid Tissue; Macaca; Organophosphonates; Prodrugs; Rectum; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Substrate Specificity; Tenofovir | 2011 |
Long-term renal safety of tenofovir disoproxil fumarate in vertically HIV-infected children, adolescents and young adults: a 60-month follow-up study.
Topics: Adenine; Adolescent; Adult; Child; Cohort Studies; Creatinine; Female; Follow-Up Studies; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
Methoxyethylamino-numonafide is an efficacious and minimally toxic amonafide derivative in murine models of human cancer.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line; Disease Models, Animal; Gene Expression Profiling; Humans; Liver Neoplasms, Experimental; Mice; Mice, Nude; Naphthalimides; Organophosphonates; Stomach Neoplasms; Transplantation, Heterologous | 2011 |
Increased risk of abnormal proximal renal tubular function with HIV infection and antiretroviral therapy.
Topics: Adenine; Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Cross-Sectional Studies; Fanconi Syndrome; Female; France; HIV Infections; HIV-1; Humans; Kidney Tubules, Proximal; Logistic Models; Male; Middle Aged; Odds Ratio; Oligopeptides; Organophosphonates; Prevalence; Pyridines; Risk Assessment; Risk Factors; Tenofovir; Time Factors | 2011 |
Development of immunity against hepatitis B virus after donor lymphocyte infusion in a peripheral blood stem cell transplantation recipient with chronic hepatitis B.
Topics: Adenine; Adoptive Transfer; Antiviral Agents; DNA, Viral; Drug Combinations; Female; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Leukemia, Myeloid, Acute; Lymphocyte Transfusion; Middle Aged; Organophosphonates; Peripheral Blood Stem Cell Transplantation; Taiwan; Treatment Outcome; Unrelated Donors | 2011 |
Two patterns of alanine aminotransferase increase to predict long-term viral response in chronic hepatitis B patients: virus- or host-induced?
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Guanine; Hepacivirus; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-gamma; Lamivudine; Male; Middle Aged; Nucleosides; Organophosphonates; Predictive Value of Tests; Pyrimidinones; T-Lymphocytes; Telbivudine; Thymidine; Treatment Outcome; Up-Regulation; Young Adult | 2011 |
Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: role of intracellular tenofovir diphosphate levels and review of the literature.
Topics: Adenine; Adult; Anti-HIV Agents; Diphosphates; Fanconi Syndrome; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Osteomalacia; Radionuclide Imaging; Tenofovir; Whole Body Imaging | 2011 |
New prodrugs of Adefovir and Cidofovir.
Topics: Adenine; Animals; Antiviral Agents; Cell Line, Tumor; Cidofovir; Cytomegalovirus; Cytosine; Herpesvirus 3, Human; HIV; Humans; Organophosphonates; Prodrugs; Simplexvirus | 2011 |
Effect of antiviral therapy on the immunohistochemical expression of bcl-xL and bax protein in patients with HBeAg-negative chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Biopsy; Female; Fibrosis; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunohistochemistry; Inflammation; Interferon-alpha; Liver; Male; Middle Aged; Organophosphonates; Retrospective Studies; Severity of Illness Index | 2011 |
Study halted: no benefit seen from antiretroviral pill in preventing HIV in women.
Topics: Adenine; Adult; Africa; Anti-Retroviral Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; Humans; Organophosphonates; Patient Compliance; Pregnancy; Pregnancy Rate; Randomized Controlled Trials as Topic; Tenofovir; Treatment Failure | 2011 |
One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.
Topics: Adenine; Administration, Topical; Animals; Base Sequence; CD4-Positive T-Lymphocytes; Chimera; Disease Models, Animal; DNA Primers; Drug Evaluation, Preclinical; Female; HIV Infections; Humans; Mice; Organophosphonates; Receptors, CCR5; Reverse Transcriptase Inhibitors; Tenofovir; Vagina | 2011 |
[Efavirenz in fixed combination with tenofovir and emtricitabine. Long-term effectiveness verified in new studies].
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Clinical Trials as Topic; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; HIV-1; Humans; Medication Adherence; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load | 2011 |
Successful tenofovir treatment for fulminant hepatitis B infection in an infant.
Topics: Adenine; Antiviral Agents; Female; Hepatitis B; Humans; Infant; Organophosphonates; Tenofovir; Treatment Outcome | 2011 |
Adefovir induced hypophosphatemic osteomalacia.
Topics: Adenine; Aged; Humans; Hypophosphatemia; Male; Organophosphonates; Osteomalacia; Radionuclide Imaging; Whole Body Imaging | 2011 |
Early end for FEM-PrEP HIV prevention trial.
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; Humans; Kenya; Organophosphonates; Organophosphorus Compounds; Patient Compliance; Randomized Controlled Trials as Topic; South Africa; Tanzania; Tenofovir | 2011 |
Genetic variants of ABCC10, a novel tenofovir transporter, are associated with kidney tubular dysfunction.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Kidney; Kidney Diseases; Kidney Tubules; Male; Multidrug Resistance-Associated Proteins; Organophosphonates; Polymorphism, Single Nucleotide; Tenofovir | 2011 |
Development and validation of an LC/MS/MS method for the determination of tenofovir in monkey plasma.
Topics: Adenine; Animals; Anti-HIV Agents; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Stability; Half-Life; Limit of Detection; Macaca mulatta; Male; Organophosphonates; Prodrugs; Reproducibility of Results; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tenofovir; Therapeutic Equivalency | 2011 |
Synergy against drug-resistant HIV-1 with the microbicide antiretrovirals, dapivirine and tenofovir, in combination.
Topics: Adenine; Drug Resistance, Viral; Drug Therapy, Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Pyrimidines; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
Parallel decline of CD8+CD38+ lymphocytes and viremia in treated hepatitis B patients.
Topics: Adenine; ADP-ribosyl Cyclase 1; Adult; CD3 Complex; Female; Hepatitis B, Chronic; Humans; Male; Membrane Glycoproteins; Middle Aged; Organophosphonates; T-Lymphocyte Subsets; Viremia | 2011 |
Delayed maturation of antibody avidity but not seroconversion in rhesus macaques infected with simian HIV during oral pre-exposure prophylaxis.
Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Antibodies, Viral; Antibody Affinity; Deoxycytidine; Drug Combinations; Emtricitabine; HIV; HIV Antibodies; Human Immunodeficiency Virus Proteins; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load | 2011 |
Early changes in parathyroid hormone concentrations in HIV-infected patients initiating antiretroviral therapy with tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Bone Density; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Female; Follow-Up Studies; HIV Seropositivity; Humans; Lamivudine; Longitudinal Studies; Male; Organophosphonates; Parathyroid Hormone; Tenofovir; Vitamin D; Vitamin D Deficiency | 2012 |
Hepatitis: PEG-IFN for the treatment of hepatitis D.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Hepatitis B, Chronic; Hepatitis D; Humans; Interferon alpha-2; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome | 2011 |
Relationship between renal dysfunction, nephrotoxicity and death among HIV adults on tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Creatinine; Female; HIV Infections; Humans; Kidney; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Risk Factors; South Africa; Tenofovir | 2011 |
Population pharmacokinetics of atazanavir/ritonavir in HIV-1-infected children and adolescents.
Topics: Adenine; Adolescent; Anti-HIV Agents; Atazanavir Sulfate; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Drug Monitoring; Female; Follow-Up Studies; HIV Infections; Humans; Male; Models, Biological; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Tissue Distribution | 2011 |
Abacavir use and risk of acute myocardial infarction and cerebrovascular events in the highly active antiretroviral therapy era.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Female; HIV Infections; Humans; Ischemic Attack, Transient; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Organophosphonates; Proportional Hazards Models; Renal Insufficiency, Chronic; Risk Factors; Stroke; Tenofovir; United States; United States Department of Veterans Affairs | 2011 |
Epidemiological impact of tenofovir gel on the HIV epidemic in South Africa.
Topics: Adenine; Anti-HIV Agents; Cost-Benefit Analysis; Female; HIV Infections; Humans; Incidence; Models, Biological; Organophosphonates; Prevalence; South Africa; Tenofovir; Vaginal Creams, Foams, and Jellies | 2011 |
Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr-PMEDAP.
Topics: Adenine; Administration, Cutaneous; Animals; Antineoplastic Agents; Antiviral Agents; Caproates; Dimethylamines; Dodecanol; Humans; Hydrogen-Ion Concentration; Methylamines; Organophosphonates; Permeability; Skin; Swine | 2011 |
Predictors of relapse in chronic hepatitis B after discontinuation of anti-viral therapy.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Real-Time Polymerase Chain Reaction; Recurrence; Time Factors | 2011 |
Successful switch to tenofovir after suboptimal response to entecavir in an immunocompromised patient with chronic hepatitis B and without genotypic hepatitis B virus resistance.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Bone Marrow; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Italy; Organophosphonates; Tenofovir; Treatment Outcome; Viremia | 2011 |
Pharmacokinetics of switching unboosted atazanavir coadministered with tenofovir disoproxil fumarate from 400 mg once daily to 200 mg twice daily in HIV-positive patients.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; HIV Seropositivity; HIV-1; Humans; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2011 |
Changes of serum levels of keratin-18 fragments in hepatitis B e antigen-negative chronic hepatitis B patients under oral antiviral therapy.
Topics: Adenine; Administration, Oral; Antiviral Agents; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Keratin-18; Lamivudine; Organophosphonates | 2011 |
Adefovir serum levels do not differ between responders and nonresponders.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Chromatography, High Pressure Liquid; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Treatment Failure | 2011 |
Large-scale survey of naturally occurring HBV polymerase mutations associated with anti-HBV drug resistance in untreated patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Mutation; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2011 |
Unsuccessful therapy with adefovir and entecavir-tenofovir in a patient with chronic hepatitis B infection with previous resistance to lamivudine: a fourteen-year evolution of hepatitis B virus mutations.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Middle Aged; Mutation; Organophosphonates; Tenofovir; Treatment Failure | 2011 |
Effect of HBV polymerase inhibitors on renal function in patients with chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Antiviral Agents; Case-Control Studies; Female; Gene Products, pol; Glomerular Filtration Rate; Hepatitis B, Chronic; HIV Infections; Humans; Linear Models; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Young Adult | 2011 |
Engineering tenofovir loaded chitosan nanoparticles to maximize microbicide mucoadhesion.
Topics: Adenine; Adhesiveness; Analysis of Variance; Animals; Anti-HIV Agents; Cell Survival; Chitosan; Drug Carriers; Drug Compounding; Epithelial Cells; Epithelium; Female; HIV Infections; Humans; In Vitro Techniques; Lactobacillus; Microscopy, Electron, Transmission; Nanoparticles; Organophosphonates; Particle Size; Solubility; Surface Properties; Swine; Tenofovir; Vagina | 2011 |
Renal impairment in HIV-1 infected patients receiving antiretroviral regimens including tenofovir in a resource-limited setting.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Anti-Retroviral Agents; Female; HIV Infections; HIV-1; Humans; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Protease Inhibitors; Renal Insufficiency; Retrospective Studies; Tenofovir; Thailand | 2011 |
Determination of kidney function before tenofovir initiation: four-fold difference in need of tenofovir dose reduction depending on method used.
Topics: Adenine; Adult; Anti-HIV Agents; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Male; Organophosphonates; Retrospective Studies; Tenofovir | 2011 |
Comparison of abacavir/lamivudine and tenofovir/emtricitabine among treatment-naive HIV-infected patients initiating therapy.
Topics: Adenine; Adult; Anti-HIV Agents; Canada; Cohort Studies; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Substitution; Emtricitabine; Female; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Failure; Virus Replication | 2011 |
Tenofovir and emtricitabine cerebrospinal fluid-to-plasma ratios correlate to the extent of blood-brainbarrier damage.
Topics: Adenine; Adult; Blood-Brain Barrier; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Pilot Projects; Tenofovir | 2011 |
Membranous nephropathy in an HIV-positive patient complicated with hepatitis B virus infection.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Emtricitabine; Glomerulonephritis, Membranous; Hepatitis B; HIV Infections; Humans; Male; Nephrotic Syndrome; Organophosphonates; Prednisolone; Tenofovir | 2011 |
The HIV reverse transcriptase inhibitor tenofovir induces cell cycle arrest in human cancer cells.
Topics: Adenine; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cytostatic Agents; Deoxycytidine; DNA Breaks, Double-Stranded; Doxorubicin; Drug Combinations; Drug Screening Assays, Antitumor; Emtricitabine; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; Histones; HIV Reverse Transcriptase; Humans; Organophosphonates; Organophosphorus Compounds; Ovarian Neoplasms; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors | 2012 |
Nephrotoxicity, including acquired Fanconi's syndrome, caused by adefovir dipivoxil - is there a safe dose?
Topics: Adenine; Aged; Antiviral Agents; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Hepatitis B, Chronic; Humans; Organophosphonates | 2012 |
Determination of nucleoside analog mono-, di-, and tri-phosphates in cellular matrix by solid phase extraction and ultra-sensitive LC-MS/MS detection.
Topics: Adenine; Anion Exchange Resins; Antiviral Agents; Calibration; Chromatography, Liquid; Deoxycytidine; Diphosphates; Emtricitabine; Humans; Lamivudine; Leukocytes, Mononuclear; Nucleosides; Organophosphonates; Phosphates; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Tenofovir; Zidovudine | 2011 |
Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication.
Topics: Adenine; Antiviral Agents; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Organophosphonates; Prodrugs; Virus Replication | 2011 |
Product and process understanding of a novel pediatric anti-HIV tenofovir niosomes with a high-pressure homogenizer.
Topics: Adenine; Anti-HIV Agents; Child; Drug Carriers; Drug Compounding; Excipients; Humans; Liposomes; Multivariate Analysis; Organophosphonates; Particle Size; Pediatrics; Regression Analysis; Solubility; Surface Properties; Suspensions; Tenofovir | 2011 |
pH-responsive nanoparticles releasing tenofovir intended for the prevention of HIV transmission.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Cell Line; Cell Survival; Drug Carriers; Drug Compounding; Epithelial Cells; Female; HIV Infections; Humans; Hydrogen-Ion Concentration; Lactic Acid; Lactobacillus; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nanoparticles; Organophosphonates; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymethacrylic Acids; Solubility; Surface Properties; Tenofovir; Vagina | 2011 |
Serum HBsAg decline during long-term potent nucleos(t)ide analogue therapy for chronic hepatitis B and prediction of HBsAg loss.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Tenofovir | 2011 |
Antiviral drug resistance testing in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Data Collection; Decision Making; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Surveys and Questionnaires; Tenofovir; Treatment Outcome; Viral Load | 2012 |
Late onset of hepatitis B virus reactivation following hematopoietic stem cell transplantation: successful treatment with combined entecavir plus tenofovir therapy.
Topics: Adenine; Age of Onset; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hematopoietic Stem Cell Transplantation; Hepatitis B; Hepatitis B virus; Humans; Middle Aged; Organophosphonates; Tenofovir; Transplantation, Homologous; Treatment Outcome; Virus Activation | 2012 |
High frequency of CD4+ CXCR5+ TFH cells in patients with immune-active chronic hepatitis B.
Topics: Adaptive Immunity; Adenine; Adult; Alanine Transaminase; Animals; Antiviral Agents; Aspartate Aminotransferases; CD4 Antigens; Cytokines; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Organophosphonates; Receptors, CXCR5; T-Lymphocytes, Helper-Inducer; Young Adult | 2011 |
Severe acute renal failure in an HIV-infected patient after only 2 weeks of tenofovir-based antiretroviral therapy.
Topics: Acute Kidney Injury; Adenine; Anti-HIV Agents; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2011 |
IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques.
Topics: Adaptive Immunity; Adenine; Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine; Drug Evaluation, Preclinical; Drug Therapy, Combination; Emtricitabine; Immunity, Mucosal; Immunologic Factors; Immunotherapy; Interleukin-15; Lymphocyte Activation; Lymphoid Tissue; Macaca mulatta; Mucous Membrane; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Random Allocation; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Treatment Failure; Viral Load | 2011 |
Subcellular renal proximal tubular mitochondrial toxicity with tenofovir treatment.
Topics: Adenine; Animals; Cardiomyopathies; Cell Separation; DNA, Mitochondrial; Female; HIV Infections; HIV-1; Humans; Kidney Tubules, Proximal; Lasers; Liver Failure; Male; Mice; Mice, Inbred C57BL; Microdissection; Mitochondria; Organophosphonates; Reverse Transcriptase Inhibitors; Staining and Labeling; Tenofovir | 2011 |
Rilpivirine: a step forward in tailored HIV treatment.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Clinical Trials, Phase III as Topic; Cyclopropanes; Delavirdine; Deoxycytidine; Drug Design; Drug Resistance, Viral; Emtricitabine; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Multicenter Studies as Topic; Mutation; Nevirapine; Nitriles; Organophosphonates; Pyrimidines; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; Viral Load | 2011 |
Antiretrovirals for HIV prevention: translating promise into praxis.
Topics: Adenine; Administration, Cutaneous; Administration, Oral; Algorithms; Anti-HIV Agents; Anti-Retroviral Agents; Congresses as Topic; Deoxycytidine; Emtricitabine; Female; Gels; Global Health; HIV Infections; Humans; Organophosphonates; Primary Prevention; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Sexual Behavior; Tenofovir; Treatment Outcome; Women's Health | 2011 |
Drug concentrations after topical and oral antiretroviral pre-exposure prophylaxis: implications for HIV prevention in women.
Topics: Adenine; Administration, Intravaginal; Administration, Oral; Africa South of the Sahara; Anti-HIV Agents; Anti-Retroviral Agents; Coitus; Deoxycytidine; Early Termination of Clinical Trials; Emtricitabine; Female; Gels; HIV Infections; Humans; Incidence; Organophosphonates; Primary Prevention; Randomized Controlled Trials as Topic; Rectum; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Vagina; Women's Health | 2011 |
Tenofovir works as pre-exposure prophylaxis against HIV, two studies confirm.
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Organophosphonates; Randomized Controlled Trials as Topic; Sexual Partners; Tenofovir | 2011 |
Cost and cost-effectiveness of switching from d4T or AZT to a TDF-based first-line regimen in a resource-limited setting in rural Lesotho.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cost-Benefit Analysis; Developing Countries; Female; Health Care Costs; HIV Infections; Humans; Lesotho; Male; Middle Aged; Organophosphonates; Pregnancy; Rural Population; Stavudine; Tenofovir; Zidovudine | 2011 |
Battles with donors cloud Malawi's HIV prevention plan.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Charities; Cyclopropanes; Drug Costs; Drug Therapy, Combination; Female; Health Policy; HIV Seropositivity; Humans; Infectious Disease Transmission, Vertical; International Cooperation; Lamivudine; Malawi; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir | 2011 |
Antiretroviral prophylaxis: a defining moment in HIV control.
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Anti-Retroviral Agents; Botswana; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Kenya; Male; Organophosphonates; Tenofovir; Uganda | 2011 |
Frequency and risk factors of renal impairment during long-term adefovir dipivoxil treatment in chronic hepatitis B patients.
Topics: Adenine; Adolescent; Adult; Aged; Drug Administration Schedule; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Incidence; Kaplan-Meier Estimate; Kidney; Kidney Diseases; Lamivudine; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Organophosphonates; Proportional Hazards Models; Republic of Korea; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Young Adult | 2012 |
rtL180M mutation of hepatitis B virus is closely associated with frequent virological resistance to adefovir dipivoxil therapy.
Topics: Adenine; Biomarkers; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Multivariate Analysis; Mutation; Organophosphonates; Phenotype; Proportional Hazards Models; Republic of Korea; Reverse Transcriptase Inhibitors; Risk Assessment; Risk Factors; RNA-Directed DNA Polymerase; Time Factors; Viral Load | 2012 |
Association of osteonecrosis and osteoporosis in HIV-1-infected patients.
Topics: Absorptiometry, Photon; Adenine; Alcohol Drinking; Anti-HIV Agents; California; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Osteonecrosis; Osteoporosis; Prednisolone; Tenofovir | 2011 |
Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
Topics: Adenine; Animals; Antiviral Agents; Biological Availability; Drug Design; Drug Resistance, Viral; Guanine; Hep G2 Cells; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Mice; Models, Chemical; Molecular Structure; Mutation; Organophosphonates; Pyrimidines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tenofovir; Tetrazoles | 2011 |
A quality by design (QbD) case study on liposomes containing hydrophilic API: I. Formulation, processing design and risk assessment.
Topics: Adenine; Delayed-Action Preparations; Drug Design; Feasibility Studies; Hydrophobic and Hydrophilic Interactions; Lipids; Liposomes; Organophosphonates; Particle Size; Reverse Transcriptase Inhibitors; Risk Assessment; Tenofovir | 2011 |
Concentrations of tenofovir and emtricitabine in saliva: implications for preexposure prophylaxis of oral HIV acquisition.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Saliva; Sexual Behavior; Tenofovir | 2011 |
Evaluation of the safety and effectiveness of nevirapine plus coformulated tenofovir/emtricitabine as first-line therapy in routine clinical practice.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Female; HIV Protease Inhibitors; Humans; Male; Middle Aged; Nevirapine; Organophosphonates; RNA, Viral; Spain; Tenofovir; Viral Load | 2012 |
Bilateral pathologic hip fractures associated with antiretroviral therapy: a case report.
Topics: Accidental Falls; Adenine; Alendronate; Anti-HIV Agents; Bone Density Conservation Agents; Comorbidity; Fanconi Syndrome; Female; Femoral Neck Fractures; Fractures, Spontaneous; Hip Fractures; HIV Infections; Humans; Magnetic Resonance Imaging; Middle Aged; Organophosphonates; Osteoporotic Fractures; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure | 2011 |
Impact of small body weight on tenofovir-associated renal dysfunction in HIV-infected patients: a retrospective cohort study of Japanese patients.
Topics: Adenine; Adult; Anti-HIV Agents; Asian People; Body Weight; Cohort Studies; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Tenofovir | 2011 |
Patient-reported outcomes and low-level residual HIV-RNA in adolescents perinatally infected with HIV-1 after switching to one-pill fixed-dose regimen.
Topics: Adenine; Adolescent; Alkynes; Anti-HIV Agents; Antiviral Agents; Benzoxazines; Child; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Patient Satisfaction; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2012 |
Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C.
Topics: Adenine; Algal Proteins; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclohexanes; Drug Synergism; Enfuvirtide; Genotype; HIV Envelope Protein gp41; HIV-1; Humans; Lectins; Leukocytes, Mononuclear; Maraviroc; Microbial Sensitivity Tests; Organophosphonates; Peptide Fragments; Plant Lectins; Tenofovir; Triazoles | 2011 |
[Improvement of health-related quality of life in chronic hepatitis B patients treated with entecavir or adefovir].
Topics: Adenine; Adult; Aged; Antiviral Agents; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Quality of Life; Young Adult | 2011 |
The efficacy of entecavir therapy in chronic hepatitis B patients with suboptimal response to adevofir.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Regression Analysis; Time Factors; Treatment Outcome; Viral Load | 2011 |
A case of lactic acidosis (LA) after administration of tenofovir and metformin in a diabetic patient with recently diagnosed HIV infection.
Topics: Acidosis, Lactic; Adenine; Anti-HIV Agents; Diabetes Mellitus, Type 2; HIV Infections; Humans; Hypoglycemic Agents; Male; Metformin; Organophosphonates; Reverse Transcriptase Inhibitors | 2011 |
Antiretroviral therapy alone resulted in successful resolution of large idiopathic esophageal ulcers in a patient with acute retroviral syndrome.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Esophageal Diseases; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Pyrimidinones; Ritonavir; RNA, Viral; Syndrome; Tenofovir; Ulcer | 2011 |
Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.
Topics: Adenine; Animals; Antiviral Agents; Area Under Curve; Biological Availability; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cidofovir; Cowpox virus; Cytomegalovirus; Cytosine; Fibroblasts; Herpesvirus 1, Human; Humans; Inhibitory Concentration 50; Mice; Models, Chemical; Molecular Structure; Organophosphonates; Prodrugs; Rats; Tyrosine; Vaccinia virus | 2011 |
Efficacy and safety of a switch to unboosted atazanavir in combination with nucleoside analogues in HIV-1-infected patients with virological suppression under antiretroviral therapy.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Cohort Studies; Deoxycytidine; Dideoxynucleosides; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Retrospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Viral Load | 2011 |
A biomimetic chitosan derivates: preparation, characterization and transdermal enhancement studies of N-arginine chitosan.
Topics: Adenine; Administration, Cutaneous; Animals; Antiviral Agents; Arginine; Biomimetics; Cell-Penetrating Peptides; Chitosan; Diffusion Chambers, Culture; Drug Delivery Systems; Hydrogen-Ion Concentration; Male; Mice; Mice, Inbred Strains; Organophosphonates; Permeability; Skin; Skin Diseases; Spectroscopy, Fourier Transform Infrared | 2011 |
A comparison of tenofovir-associated renal function changes in HIV-infected African Americans vs Caucasians.
Topics: Adenine; Adult; Anti-HIV Agents; Black or African American; Creatinine; Drug Monitoring; Female; Glomerular Filtration Rate; HIV; HIV Infections; Humans; Kidney; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Tenofovir; United States; White People; Withholding Treatment | 2011 |
HIV-HBV vaccine escape mutant infection with loss of HBV surface antibody and persistent HBV viremia on tenofovir/emtricitabine without antiviral resistance.
Topics: Adenine; Antiviral Agents; Coinfection; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Hepatitis B; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B virus; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation; Organophosphonates; Tenofovir; Viral Load; Viremia | 2011 |
Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy.
Topics: Adenine; Anti-Retroviral Agents; Cell Line; Drug Resistance, Viral; HEK293 Cells; HIV Infections; HIV-1; Humans; Models, Biological; Organophosphonates; Tenofovir; Virus Replication | 2011 |
Impact of tenofovir versus abacavir on HIV-related endothelial dysfunction.
Topics: Adenine; Adult; Anti-HIV Agents; Case-Control Studies; Chemokine CCL2; Dideoxynucleosides; Endothelium, Vascular; Female; HIV Infections; HIV-1; Humans; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Vascular Cell Adhesion Molecule-1; Vasodilation | 2011 |
Comparative outcomes of tenofovir-based and zidovudine-based antiretroviral therapy regimens in Lusaka, Zambia.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; Humans; Male; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Risk Factors; Tenofovir; Zambia; Zidovudine | 2011 |
Population pharmacokinetics of tenofovir in HIV-1-infected pediatric patients.
Topics: Adenine; Adolescent; Anti-HIV Agents; Child; Child, Preschool; HIV Infections; HIV-1; Humans; Kidney; Organophosphonates; Plasma; Tenofovir | 2011 |
Modeling interventions to assess HIV epidemic impact in Africa.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Organophosphonates; Tenofovir | 2011 |
Persistent decline in estimated but not measured glomerular filtration rate on tenofovir may reflect tubular rather than glomerular toxicity.
Topics: Adenine; Adult; Alpha-Globulins; Anti-HIV Agents; Creatinine; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Kidney Glomerulus; Kidney Tubules; Male; Middle Aged; Organophosphonates; Randomized Controlled Trials as Topic; Renal Plasma Flow, Effective; Serum Albumin; Tenofovir; Time Factors; Treatment Outcome | 2011 |
The YMDD and rtA194T mutations result in decreased replication capacity in wild-type HBV as well as in HBV with precore and basal core promoter mutations.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Gene Products, pol; Genotype; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Tenofovir; Virus Replication | 2011 |
[Effect of shugan jianpi bushen recipe on splenic T lymphocytes and virus load in hepatitis B virus transgenic mice].
Topics: Adenine; Animals; Drugs, Chinese Herbal; Hepatitis B virus; Male; Mice; Mice, Inbred BALB C; Mice, Transgenic; Organophosphonates; Spleen; T-Lymphocyte Subsets; Viral Load; Virus Replication | 2011 |
High dose lamivudine in HBV-related cirrhotic patients with unsatisfactory response after adefovir add-on.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Failure; Viral Load; Virus Replication | 2012 |
Management options for lamivudine-resistant chronic hepatitis B patients with suboptimal virological suppression by adefovir.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2011 |
Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants.
Topics: Adenine; Antiviral Agents; Biotransformation; Brassica; Caulimovirus; DNA, Viral; Enzyme-Linked Immunosorbent Assay; Organophosphonates; Polymerase Chain Reaction; Tenofovir; Viral Load; Viral Proteins | 2011 |
Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.
Topics: Adenine; Amino Acid Sequence; Aptamers, Nucleotide; beta-Galactosidase; DNA; HIV Reverse Transcriptase; Kinetics; Models, Molecular; Molecular Sequence Data; Moloney murine leukemia virus; Mutation; Nucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Homology, Amino Acid; Tenofovir; Xenotropic murine leukemia virus-related virus; Zidovudine | 2012 |
Long-term efficacy of entecavir therapy in chronic hepatitis B patients with antiviral resistance to lamivudine and adefovir.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome; Viral Load | 2011 |
Long-term efficacy of entecavir in adefovir-refractory chronic hepatitis B patients with prior lamivudine resistance.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Salvage Therapy; Treatment Outcome | 2011 |
Optimizing initial therapy for HIV infection.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Female; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Tenofovir | 2011 |
Fanconi syndrome-like tubular acidosis associated with a tenofovir-containing antiretroviral regimen in a human immunodeficiency virus-1-infected Asian woman.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Fanconi Syndrome; Female; HIV Infections; HIV-1; Humans; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Iatrogenic Cushing syndrome after a single intramuscular corticosteroid injection and concomitant protease inhibitor therapy.
Topics: Adenine; Adrenal Insufficiency; Adult; Atazanavir Sulfate; Cushing Syndrome; Cytochrome P-450 Enzyme Inhibitors; Female; HIV Protease Inhibitors; HIV Seropositivity; Humans; Iatrogenic Disease; Injections, Intramuscular; Lamivudine; Oligopeptides; Organophosphonates; Pruritus; Pyridines; Ritonavir; Tenofovir; Triamcinolone Acetonide | 2011 |
Predictors of HBeAg status and hepatitis B viraemia in HIV-infected patients with chronic hepatitis B in the HAART era in Brazil.
Topics: Adenine; Adult; Alanine Transaminase; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Brazil; CD4 Lymphocyte Count; Cross-Sectional Studies; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Factors; Tenofovir; Viral Load; Viremia | 2011 |
Optimization of adefovir therapy in chronic hepatitis B according to baseline predictors and on-treatment HBV DNA: a 5-year prospective study.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; China; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Prospective Studies; Treatment Outcome | 2011 |
Virological response to adefovir monotherapy and the risk of adefovir resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies | 2011 |
Rapid high-performance liquid chromatographic method for determination of adefovir in plasma using UV detection: application to pharmacokinetic studies.
Topics: Adenine; Adult; Antiviral Agents; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Humans; Indicators and Reagents; Male; Organophosphonates; Reference Standards; Reproducibility of Results; Solutions; Spectrophotometry, Ultraviolet | 2011 |
Novel naphthalimide-benzoic acid conjugates as potential apoptosis-inducing agents: design, synthesis, and biological activity.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Benzoic Acid; Cell Line, Tumor; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Naphthalimides; Organophosphonates; Structure-Activity Relationship | 2011 |
Design and synthesis of carbocyclic versions of furanoid nucleoside phosphonic Acid analogues as potential anti-hiv agents.
Topics: Adenine; Anti-HIV Agents; Cell Line; Drug Design; Furans; Guanine; HIV-1; Humans; Molecular Structure; Organophosphonates | 2011 |
Assessing recovery of renal function after tenofovir disoproxil fumarate discontinuation.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Drug Administration Schedule; Female; Glomerular Filtration Rate; HIV Infections; Humans; Japan; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Young Adult | 2012 |
[A case with poly-bone pain, decrease of bone density and in crease of serum creatinine related to adefovir dipivoxil treatment in a chronic hepatitis B patient].
Topics: Adenine; Adult; Bone Density; Creatinine; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Pain; Phosphorus | 2011 |
Scientific report: highlights of 24th ICAR, 8-11 May 2011, Sofia, Bulgaria.
Topics: Adenine; Animals; Antiviral Agents; Arenavirus; Chemistry, Pharmaceutical; Communicable Diseases, Emerging; Cytosine; Flavivirus; Hepacivirus; HIV Seropositivity; Humans; Organophosphonates; Prodrugs; Smallpox; Tenofovir; Virus Replication | 2011 |
Pharmacokinetics of tenofovir following intravaginal and intrarectal administration of tenofovir gel to rhesus macaques.
Topics: Adenine; Administration, Intravaginal; Administration, Rectal; Animals; Antiviral Agents; Area Under Curve; Body Fluids; Dose-Response Relationship, Drug; Female; Gels; HIV Infections; HIV-1; Humans; Macaca mulatta; Organophosphonates; Rectum; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Vagina | 2012 |
Adefovir dipivoxil modulates cytokine expression in Th1/Th2 cells in patients with chronic hepatitis B.
Topics: Adenine; Administration, Oral; Adult; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Cytokines; DNA, Viral; Female; Gene Expression Regulation; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Th1 Cells; Th2 Cells; Time Factors | 2012 |
Microbicide might protect pregnant women from HIV. Susceptibility is high for them.
Topics: Adenine; Disease Susceptibility; Female; HIV Infections; Humans; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
Evaluation of functional respiratory parameters in AIDS patients assisted in the infectious diseases ambulatory care clinic of a tertiary care university hospital in Brazil.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; Brazil; Cross-Sectional Studies; Female; Hospitals, University; Humans; Male; Middle Aged; Muscle Strength; Organophosphonates; Outpatient Clinics, Hospital; Prospective Studies; Respiration; Respiratory Function Tests; Respiratory Muscles; Spirometry; Tenofovir | 2012 |
Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.
Topics: Adenine; Adult; Albuminuria; Alkynes; Anti-HIV Agents; Benzoxazines; Brachial Artery; Chi-Square Distribution; Creatinine; Cyclopropanes; Dideoxynucleosides; Endothelium, Vascular; Female; Glomerular Filtration Rate; HIV Infections; Humans; Linear Models; Male; Middle Aged; Organophosphonates; Proteinuria; Tenofovir; Ultrasonography; Vasodilation | 2011 |
Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication.
Topics: Adenine; Administration, Topical; Animals; Anti-Infective Agents; Cells, Cultured; DNA-Directed DNA Polymerase; DNA, Viral; Exodeoxyribonucleases; Herpes Genitalis; Herpesvirus 2, Human; HIV Reverse Transcriptase; Humans; Mice; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Sequence Analysis, DNA; Tenofovir; Thymidine Kinase; Viral Proteins | 2011 |
Efficacy, adherence and tolerability of once daily tenofovir DF-containing antiretroviral therapy in former injecting drug users with HIV-1 receiving opiate treatment: results of a 48-week open-label study.
Topics: Adenine; Adult; Analgesics, Opioid; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Follow-Up Studies; HIV Infections; HIV-1; Humans; Male; Maximum Tolerated Dose; Medication Adherence; Methadone; Middle Aged; Organophosphonates; Substance Abuse, Intravenous; Survival Rate; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2011 |
Bone turnover, osteoprotegerin/RANKL and inflammation with antiretroviral initiation: tenofovir versus non-tenofovir regimens.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Biomarkers; Bone Density; Bone Remodeling; CD4 Lymphocyte Count; Collagen Type I; Cytokines; Female; HIV Infections; Humans; Inflammation; Longitudinal Studies; Male; NF-kappa B; Organophosphonates; Osteoprotegerin; Protease Inhibitors; RANK Ligand; Tenofovir; Tumor Necrosis Factor-alpha; Young Adult | 2011 |
Resistance data in the ARTEN trial.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Female; HIV Infections; Humans; Male; Nevirapine; Oligopeptides; Organophosphonates; Pyridines; Ritonavir | 2011 |
Novel polymorphic form of adefovir dipivoxil derived from polymer-directed crystallization.
Topics: Adenine; Antiviral Agents; Calorimetry, Differential Scanning; Crystallization; Microscopy, Electron, Scanning; Models, Molecular; Organophosphonates; Particle Size; Polymers; Powders; Solubility; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2011 |
Adefovir-based combination therapy with entecavir or lamivudine for patients with entecavir-refractory chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
Entecavir plus tenofovir combination as rescue therapy in pre-treated chronic hepatitis B patients: an international multicenter cohort study.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Internationality; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome; Viremia; Young Adult | 2012 |
Effects of HAART on platelet-activating factor metabolism in naive HIV-infected patients I: study of the tenofovir-DF/emtricitabine/efavirenz HAART regimen.
Topics: Adenine; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Male; Organophosphonates; Oxazines; Platelet Activating Factor; Viral Load | 2012 |
[Lamivudine-resistant analysis and management for chronic hepatitis B patients with initial lamivudine therapy].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2011 |
[HBV resistance mutants before and after adefovir dipivoxil treatment and the relationship with HBV genotypes].
Topics: Adenine; Adult; Drug Resistance, Viral; Female; Genes, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates | 2011 |
Canadian patients with chronic hepatitis B cannot access appropriate drug treatments: a call for change.
Topics: Adenine; Antiviral Agents; Canada; Drug Approval; Guanine; Health Services Accessibility; Hepatitis B, Chronic; Humans; Insurance Coverage; Lamivudine; Liver Cirrhosis; National Health Programs; Organophosphonates; Tenofovir | 2011 |
Pre-exposure chemoprophylaxis of HIV infection: quo vadis?
Topics: Adenine; Administration, Intravaginal; Administration, Oral; Administration, Topical; Anti-HIV Agents; Clinical Trials as Topic; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Molecular Structure; Organophosphonates; Patient Compliance; Tenofovir | 2012 |
Sustained virological response to a raltegravir-containing salvage therapy in an HIV-2-infected patient.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; CD4 Lymphocyte Count; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV Protease Inhibitors; HIV-2; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Salvage Therapy; Tenofovir; Treatment Outcome; Viral Load | 2011 |
The price of tenofovir-emtricitabine undermines the cost-effectiveness and advancement of pre-exposure prophylaxis.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Cost-Benefit Analysis; Deoxycytidine; Drug Costs; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Models, Economic; Organophosphonates; Tenofovir | 2011 |
Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue.
Topics: Adenine; Animals; Anti-HIV Agents; Cells, Cultured; Drug Stability; Female; Half-Life; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Longitudinal Studies; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies | 2012 |
Cost effectiveness of tenofovir disoproxil fumarate for the treatment of chronic hepatitis B from a Canadian public payer perspective.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Canada; Cost-Benefit Analysis; Female; Health Care Costs; Hepatitis B virus; Hepatitis B, Chronic; Humans; Insurance, Health, Reimbursement; Male; National Health Programs; Organophosphonates; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Tenofovir; Young Adult | 2011 |
Molecular characterization of a novel entecavir mutation pattern isolated from a multi-drug refractory patient with chronic hepatitis B infection.
Topics: Adenine; Adult; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Multiple, Viral; Fatal Outcome; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Microbial Sensitivity Tests; Mutation; Organophosphonates; Virus Replication | 2012 |
Polymorphic and kinetic investigation of adefovir dipivoxil during phase transformation.
Topics: Adenine; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Crystallography, X-Ray; Kinetics; Models, Chemical; Organophosphonates; Phase Transition; Powder Diffraction; Reverse Transcriptase Inhibitors; Solubility; Technology, Pharmaceutical; Thermogravimetry; Transition Temperature | 2012 |
A prospective clinical study in hepatitis B e antigen-negative chronic hepatitis B patients with stringent cessation criteria for adefovir.
Topics: Adenine; Adult; Antiviral Agents; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Treatment Outcome; Withholding Treatment; Young Adult | 2012 |
Antiviral breadth and combination potential of peptide triazole HIV-1 entry inhibitors.
Topics: Adenine; Anti-HIV Agents; Cell Line; Drug Therapy, Combination; HIV Envelope Protein gp120; HIV Fusion Inhibitors; HIV-1; Humans; Organophosphonates; Peptides; Reverse Transcriptase Inhibitors; Tenofovir; Triazoles; Virus Replication | 2012 |
Acceptability of an "on-demand" pre-exposure HIV prophylaxis trial among men who have sex with men living in France.
Topics: Adenine; Adult; Anti-HIV Agents; Chemoprevention; Deoxycytidine; Drug Combinations; Educational Status; Emtricitabine; France; HIV Infections; HIV Serosorting; Homosexuality, Male; Humans; Male; Organophosphonates; Patient Acceptance of Health Care; Patient Selection; Post-Exposure Prophylaxis; Research Subjects; Risk Reduction Behavior; Self Administration; Tenofovir; Unsafe Sex | 2012 |
Re.: Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Pregnancy | 2011 |
Re.: Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates | 2011 |
[New drugs of treatment of patients with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Deoxycytidine; Emtricitabine; Hepatitis B, Chronic; Humans; Nucleosides; Organophosphonates; Pyrimidinones; Telbivudine; Tenofovir; Thymidine | 2011 |
Long-term outcome of primary non-responders to tenofovir therapy in HIV/HBV-co-infected patients: impact of HBV genotype G.
Topics: Adenine; Adult; Anti-HIV Agents; Coinfection; Deoxycytidine; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Genotype; Hepatitis B; Hepatitis B virus; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Tenofovir; Time Factors; Treatment Outcome | 2012 |
Tenofovir plus entecavir as rescue therapy for multidrug-resistant chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Substitution; Drug Therapy, Combination; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Mutation; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load; Virus Replication | 2012 |
Potent hepatitis B surface antigen response to treatment of hepatitis-B-e-antigen-positive chronic hepatitis B with α-interferon plus a nucleos(t)ide analog.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Retrospective Studies; Time Factors; Young Adult | 2012 |
Different baseline characteristics and different outcomes of HIV-infected patients receiving HAART through clinical trials compared with routine care in Mexico.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD4 Lymphocyte Count; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Epidemiologic Methods; Female; HIV Infections; Humans; Kaplan-Meier Estimate; Lopinavir; Male; Mexico; Nevirapine; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir | 2012 |
Tenofovir induced acute kidney injury in a patient with unilateral renal agenesis despite initially non-impaired renal function.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Congenital Abnormalities; HIV Infections; Humans; Kidney; Kidney Diseases; Male; Organophosphonates; Tenofovir | 2011 |
Simultaneous delivery of tenofovir and acyclovir via an intravaginal ring.
Topics: Acyclovir; Adenine; Administration, Intravaginal; Animals; Anti-HIV Agents; Antiviral Agents; Delayed-Action Preparations; Disease Models, Animal; Drug Combinations; Drug Delivery Systems; Equipment Design; Female; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; HIV-1; Humans; Organophosphonates; Rabbits; Sexually Transmitted Diseases, Viral; Tenofovir; Treatment Outcome | 2012 |
Pregnancy-related effects on tenofovir pharmacokinetics: a population study with 186 women.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Drug Monitoring; Female; HIV Infections; HIV-1; Humans; Middle Aged; Models, Biological; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Reverse Transcriptase Inhibitors; Tenofovir; Young Adult | 2012 |
In vitro resistance profile of the candidate HIV-1 microbicide drug dapivirine.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation; Organophosphonates; Pyrimidines; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
[Adefovir dipivoxil-induced Fanconi syndrome and hypophosphatemic osteomalacia associated with muscular weakness in a patient with chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Bone Diseases, Metabolic; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Muscle Weakness; Organophosphonates; Osteomalacia; Young Adult | 2011 |
Does therapy-related AML have a poor prognosis, independent of the cytogenetic/molecular determinants?
Topics: Adenine; Anthracyclines; Antineoplastic Agents; Biomarkers, Tumor; Cytarabine; Cytogenetics; Female; Germany; Humans; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; Naphthalimides; Naphthyridines; Organophosphonates; Prognosis; Remission Induction; Retrospective Studies; Survival Rate; Thiazoles | 2011 |
Efficacy of entecavir and adefovir combination therapy for patients with lamivudine- and entecavir-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Monitoring; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load; Virus Replication | 2012 |
Early markers of tubular dysfunction in antiretroviral-experienced HIV-infected patients treated with tenofovir versus abacavir.
Topics: Adenine; Anti-HIV Agents; Biomarkers; Cohort Studies; Cytochromes c; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; Glomerular Filtration Rate; Glutathione Transferase; HIV Infections; Humans; Kidney Diseases; Kidney Tubules, Proximal; Lamivudine; Male; Middle Aged; Mitochondria; Organophosphonates; Tenofovir; Time Factors | 2012 |
Prevalence, virology and antiviral drugs susceptibility of hepatitis B virus rtN238H polymerase mutation from 1865 Chinese patients with chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Asian People; Child; Child, Preschool; China; Female; Genotype; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Mutation Rate; Organophosphonates; RNA-Directed DNA Polymerase; Virus Replication; Young Adult | 2012 |
Drugs in traffic: the road to approval.
Topics: 17 alpha-Hydroxyprogesterone Caproate; Abiraterone Acetate; Adenine; Androstadienes; Antibodies, Monoclonal, Humanized; Anticarcinogenic Agents; Benzhydryl Compounds; Bevacizumab; Drug Approval; Drug Industry; Glucosides; Hydroxyprogesterones; Indans; Morpholines; Natriuretic Peptide, Brain; Organophosphonates; Protein C; Recombinant Proteins; Rivaroxaban; Tenofovir; Thiophenes | 2011 |
De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Treatment Outcome | 2011 |
Evaluating the extent of potential resistance to pre-exposure prophylaxis within the UK HIV-1-infectious population of men who have sex with men.
Topics: Adenine; Anti-HIV Agents; Cohort Studies; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Homosexuality, Male; Humans; Logistic Models; Male; Organophosphonates; Prevalence; Tenofovir; United Kingdom; Viral Load | 2012 |
A quality by design (QbD) case study on liposomes containing hydrophilic API: II. Screening of critical variables, and establishment of design space at laboratory scale.
Topics: Adenine; Buffers; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Compounding; Drug Storage; Feasibility Studies; Hydrophobic and Hydrophilic Interactions; Lipids; Liposomes; Models, Statistical; Organophosphonates; Particle Size; Pressure; Quality Control; Reproducibility of Results; Reverse Transcriptase Inhibitors; Risk Assessment; Sonication; Technology, Pharmaceutical; Temperature; Tenofovir; Time Factors | 2012 |
In utero exposure to tenofovir disoproxil fumarate does not impair growth and bone health in HIV-uninfected children born to HIV-infected mothers.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Bone and Bones; Child; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Female; Fetus; HIV; HIV Infections; HIV Seropositivity; Humans; Infant; Infectious Disease Transmission, Vertical; Italy; Male; Observation; Organophosphonates; Pregnancy; Reverse Transcriptase Inhibitors; Tenofovir | 2011 |
Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells.
Topics: Adenine; Anti-HIV Agents; Apoptosis; Cardiovascular Diseases; Cell Adhesion Molecules; Coronary Vessels; Cytokines; Didanosine; Dideoxynucleosides; Endothelial Cells; Gene Expression; Gene Expression Profiling; HIV Infections; HIV-1; Humans; Inflammation; NADPH Oxidases; Organophosphonates; Oxidative Stress; Primary Cell Culture; Proto-Oncogene Proteins; Tenofovir | 2011 |
Penetration of tenofovir and emtricitabine in mucosal tissues: implications for prevention of HIV-1 transmission.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Area Under Curve; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Organophosphonates; Tenofovir | 2011 |
FDA notifications. Complera approved.
Topics: Adenine; Deoxycytidine; Drug Approval; Drug Combinations; Drug Labeling; Emtricitabine; HIV Infections; Humans; Nitriles; Organophosphonates; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; United States; United States Food and Drug Administration | 2011 |
Viral response at 6 months is associated with treatment outcome of adefovir add-on therapy for lamivudine-resistance.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Predictive Value of Tests; Proportional Hazards Models; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load | 2012 |
Recent HIV-1 infection: to treat or not to treat, that is the question.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lopinavir; Male; Organophosphonates; Ritonavir; Tenofovir; Viral Load | 2012 |
Comparison between Elecsys HBsAg II and architect HBsAg QT assays for quantification of hepatitis B surface antigen among patients coinfected with HIV and hepatitis B virus.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Coinfection; Female; Genotype; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Reagent Kits, Diagnostic; Tenofovir | 2012 |
Peripheral blood lymphocyte dynamics and viral kinetics in patients with chronic active hepatitis B virus infection treated by tenofovir.
Topics: Adenine; ADP-ribosyl Cyclase 1; Adult; Antiviral Agents; Biomarkers; CD28 Antigens; CD8-Positive T-Lymphocytes; DNA, Viral; Female; Flow Cytometry; Forkhead Transcription Factors; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunity, Cellular; Interleukin-2 Receptor alpha Subunit; Kinetics; Male; Membrane Glycoproteins; Middle Aged; Organophosphonates; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Tenofovir; Treatment Outcome; Turkey; Viral Load; Virus Replication | 2012 |
Predicting hydrophilic drug encapsulation inside unilamellar liposomes.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Adenine; Chemistry, Pharmaceutical; Dimyristoylphosphatidylcholine; Drug Compounding; Feasibility Studies; Hydrophobic and Hydrophilic Interactions; Lipids; Models, Chemical; Models, Statistical; Nanotechnology; Organophosphonates; Osmolar Concentration; Particle Size; Phosphatidylcholines; Propane; Quaternary Ammonium Compounds; Surface Properties; Technology, Pharmaceutical; Tenofovir; Unilamellar Liposomes | 2012 |
Tenofovir and tenofovir disoproxil fumarate pharmacokinetics from intravaginal rings.
Topics: Adenine; Administration, Intravaginal; Animals; Anti-HIV Agents; Female; Gas Chromatography-Mass Spectrometry; Organophosphonates; Prodrugs; Sheep; Tenofovir; Vaginal Douching | 2012 |
Sensitive and rapid HPLC quantification of tenofovir from hyaluronic acid-based nanomedicine.
Topics: Adenine; Chromatography, High Pressure Liquid; Hyaluronic Acid; Limit of Detection; Nanomedicine; Organophosphonates; Reproducibility of Results; Tenofovir; Time Factors | 2012 |
Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir.
Topics: Adenine; Adult; Cohort Studies; Female; HIV Reverse Transcriptase; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
A novel LC-MS/MS method for simultaneous quantification of tenofovir and lamivudine in human plasma and its application to a pharmacokinetic study.
Topics: Adenine; Chromatography, High Pressure Liquid; Drug Stability; Humans; Lamivudine; Linear Models; Male; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Tenofovir | 2012 |
Testing of viscous anti-HIV microbicides using Lactobacillus.
Topics: Adenine; Anilides; Animals; Anti-HIV Agents; Anti-Infective Agents, Local; Cattle; Chemokine CCL5; Colony Count, Microbial; Excipients; Female; Furans; Humans; Lactobacillus; Microbial Sensitivity Tests; Microbial Viability; Organophosphonates; Pyrimidines; Serum Albumin, Bovine; Tenofovir; Thioamides; Vagina; Viscosity | 2012 |
More trials are cut short, but not the debate over their trajectory.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Heart Failure; Humans; Niacin; Organophosphonates; Tenofovir | 2012 |
Development of a combination microbicide gel formulation containing IQP-0528 and tenofovir for the prevention of HIV infection.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Anti-Infective Agents; Cell Line; Chemistry, Pharmaceutical; Excipients; Gels; HIV-1; Humans; Organophosphonates; Pyrimidinones; Reverse Transcriptase Inhibitors; Solubility; Tenofovir; Viscosity | 2012 |
Tenofovir-induced nephrotoxicity: myths and facts.
Topics: Adenine; Animals; Anti-HIV Agents; Evidence-Based Medicine; HIV Infections; HIV-1; Humans; Kidney Diseases; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir | 2012 |
Renal function declines more in tenofovir- than abacavir-based antiretroviral therapy in low-body weight treatment-naïve patients with HIV infection.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Body Weight; Demography; Dideoxynucleosides; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kaplan-Meier Estimate; Male; Multivariate Analysis; Organophosphonates; Risk Factors; Tenofovir | 2012 |
Antiviral efficacy of combination therapy with entecavir and adefovir for entecavir/lamivudine-resistant hepatitis B virus with or without adefovir resistance.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
Discovery of drugs that possess activity against feline leukemia virus.
Topics: Adenine; Animals; Antiviral Agents; Azacitidine; Cat Diseases; Cats; Decitabine; Deoxycytidine; Dose-Response Relationship, Drug; Gemcitabine; Leukemia Virus, Feline; Leukemia, Feline; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Retroviridae Infections; Tenofovir; Tumor Virus Infections | 2012 |
Combination of antiretroviral drugs as microbicides.
Topics: Adenine; Anti-Infective Agents, Local; Anti-Retroviral Agents; Drug Therapy, Combination; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Organophosphonates; Receptors, HIV; Tenofovir | 2012 |
Transarterial chemoembolization for hepatitis B virus-associated hepatocellular carcinoma: improved survival after concomitant treatment with nucleoside analogues.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Chi-Square Distribution; Disease-Free Survival; Female; Guanine; Hepatitis B, Chronic; Humans; Japan; Kaplan-Meier Estimate; Lamivudine; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Nucleosides; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; Time Factors; Treatment Outcome | 2012 |
Entecavir plus adefovir combination treatment for chronic hepatitis B patients after failure of nucleoside/nucleotide analogues.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Combinations; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Treatment Failure; Viral Load | 2012 |
Quasispecies analysis and in vitro susceptibility of HBV strains isolated from HIV-HBV-coinfected patients with delayed response to tenofovir.
Topics: Adenine; Adult; Antiviral Agents; Cloning, Molecular; Coinfection; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Sequence Analysis, DNA; Tenofovir; Transfection | 2012 |
Renal function in HIV-infected children and adolescents treated with tenofovir disoproxil fumarate and protease inhibitors.
Topics: Adenine; Adolescent; Anti-HIV Agents; Child; Female; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Male; Organophosphonates; Prospective Studies; Tenofovir | 2012 |
Loss of control of HIV viremia associated with the fat malabsorption drug orlistat.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Obesity Agents; Deoxycytidine; Drug Combinations; Drug Interactions; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV; HIV Seropositivity; Humans; Lactones; Male; Nonprescription Drugs; Obesity; Organophosphonates; Orlistat; Oxazines; Reverse Transcriptase Inhibitors; RNA, Viral; Viral Load | 2012 |
An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Nucleic Acid Hybridization; Organophosphonates; Sequence Analysis, DNA | 2012 |
Anti-HDV immunoglobulin M testing in hepatitis delta revisited: correlations with disease activity and response to pegylated interferon-α2a treatment.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Female; gamma-Glutamyltransferase; Hepatitis Antibodies; Hepatitis D; Hepatitis Delta Virus; Humans; Immunoglobulin M; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; RNA, Viral; Young Adult | 2012 |
HBV DNA level at 24 weeks is the best predictor of virological response to adefovir add-on therapy in patients with lamivudine resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load | 2012 |
HIV preexposure prophylaxis: new data and potential use.
Topics: Adenine; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Evidence-Based Medicine; Female; HIV Infections; HIV-1; Homosexuality, Male; Humans; Male; Organophosphonates; Tenofovir | 2011 |
Effect of abacavir on acute changes in biomarkers associated with cardiovascular dysfunction.
Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Dideoxynucleosides; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Risk Factors; Tenofovir | 2012 |
High-resolution melting and real-time PCR for quantification and detection of drug-resistant HBV mutants in a single amplicon.
Topics: Adenine; Antiviral Agents; DNA, Complementary; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Molecular Diagnostic Techniques; Nucleic Acid Denaturation; Organophosphonates; Pilot Projects; Polymerase Chain Reaction; Viral Load | 2012 |
Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Hip Fractures; HIV Infections; HIV Protease Inhibitors; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Osteoporotic Fractures; Retrospective Studies; Risk; Risk Factors; Ritonavir; Spinal Fractures; Tenofovir; Time Factors; Treatment Outcome; Wrist Injuries; Young Adult | 2012 |
A two-stage reverse dialysis in vitro dissolution testing method for passive targeted liposomes.
Topics: Adenine; Buffers; Chemistry, Pharmaceutical; Dialysis; Diffusion; Drug Compounding; Feasibility Studies; Kinetics; Lipids; Liposomes; Membranes, Artificial; Models, Chemical; Nanotechnology; Organophosphonates; Phase Transition; Solubility; Surface-Active Agents; Technology, Pharmaceutical; Temperature; Tenofovir | 2012 |
Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B.
Topics: Adenine; Adult; Enzyme-Linked Immunosorbent Assay; Female; Hep G2 Cells; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interleukin-33; Interleukins; Liver; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
An unrecognised case of tenofovir-associated Fanconi syndrome.
Topics: Adenine; Adolescent; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; Humans; Male; Organophosphonates; Tenofovir | 2012 |
Synthesis, anti-HBV activity and renal cell toxicity evaluation of mixed phosphonate prodrugs of adefovir.
Topics: Adenine; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Cell Line; Cell Survival; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Organophosphonates; Prodrugs | 2012 |
Virologic response is not durable after adefovir discontinuation in lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Recurrence; Risk Factors | 2011 |
Association of tenofovir exposure with kidney disease risk in HIV infection.
Topics: Adenine; Adult; Anti-HIV Agents; Female; Follow-Up Studies; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Failure, Chronic; Male; Middle Aged; Organophosphonates; Proteinuria; Risk Factors; Tenofovir; Time Factors; Treatment Outcome | 2012 |
Response to tenofovir monotherapy in chronic hepatitis B patients with prior suboptimal response to entecavir.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Medication Adherence; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Young Adult | 2012 |
Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility.
Topics: Adenine; Algorithms; Anti-HIV Agents; Dideoxynucleosides; Drug Resistance, Multiple, Viral; Genomics; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Least-Squares Analysis; Mutation; Nucleosides; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir; Thymidine; Zidovudine | 2012 |
Kinetics of hepatitis B surface and envelope antigen and prediction of treatment response to tenofovir in antiretroviral-experienced HIV-hepatitis B virus-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2012 |
Unraveling the divergent results of pre-exposure prophylaxis trials for HIV prevention.
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Antiviral Agents; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Patient Compliance; Risk Factors; Tenofovir; Treatment Outcome; Vaginal Creams, Foams, and Jellies | 2012 |
Hepatitis B virus variant with the a194t substitution within reverse transcriptase before and under adefovir and tenofovir therapy.
Topics: Adenine; Adult; Amino Acid Substitution; Hepatitis B virus; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir | 2012 |
Substitution of tenofovir/emtricitabine for Hepatitis B immune globulin prevents recurrence of Hepatitis B after liver transplantation.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; Emtricitabine; Female; Hepatitis B; Humans; Immunoglobulins; Liver Transplantation; Male; Middle Aged; Organophosphonates; Secondary Prevention; Tenofovir | 2012 |
Increase in serum mitochondrial creatine kinase levels induced by tenofovir administration.
Topics: Adenine; Adult; Analysis of Variance; Anti-HIV Agents; Antibodies, Monoclonal; Antiretroviral Therapy, Highly Active; Cohort Studies; Creatine Kinase, Mitochondrial Form; Electrophoresis, Agar Gel; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2012 |
Least among equals.
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Organophosphonates; Tenofovir | 2012 |
Design of tenofovir-UC781 combination microbicide vaginal gels.
Topics: Adenine; Administration, Topical; Anilides; Animals; Drug Therapy, Combination; Female; Furans; Gels; Humans; In Vitro Techniques; Organophosphonates; Rabbits; Reverse Transcriptase Inhibitors; Tenofovir; Thioamides; Vagina | 2012 |
Reduced quantitative ultrasound bone mineral density in HIV-infected patients on antiretroviral therapy in Senegal.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Retroviral Agents; Body Mass Index; Bone Density; Case-Control Studies; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Protease Inhibitors; Senegal; Tenofovir; Viral Load | 2012 |
Preservation HIV-1-specific IFNγ+ CD4+ T-cell responses in breakthrough infections after exposure to tenofovir gel in the CAPRISA 004 microbicide trial.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Infective Agents; CD4-Positive T-Lymphocytes; Female; HIV Infections; HIV-1; Humans; Interferon-gamma; Organophosphonates; South Africa; Tenofovir; Vaginal Creams, Foams, and Jellies | 2012 |
The British HIV Association/British Association for Sexual Health and HIV Position Statement on pre-exposure prophylaxis in the UK.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Tenofovir; United Kingdom | 2012 |
Severe vitamin D deficiency in a patient treated for hepatitis B with tenofovir.
Topics: Adenine; Hepatitis B; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Vitamin D Deficiency | 2012 |
Hyperhidrosis related to nevirapine therapy.
Topics: Adenine; Aged; Anti-HIV Agents; Drug Eruptions; HIV Seropositivity; Humans; Hyperhidrosis; Lamivudine; Male; Nevirapine; Organophosphonates; Tenofovir | 2012 |
Immune reconstitution renal-limited sarcoidosis presenting as acute kidney injury.
Topics: Acute Kidney Injury; Adenine; Adult; AIDS-Associated Nephropathy; Anti-Retroviral Agents; Atazanavir Sulfate; Female; HIV Infections; Humans; Oligopeptides; Organophosphonates; Prednisone; Pyridines; Ritonavir; Sarcoidosis; Tenofovir; Young Adult | 2012 |
Adverse drug reactions to antiretroviral therapy (ARVs): incidence, type and risk factors in Nigeria.
Topics: Adenine; Adolescent; Adult; Alkynes; Anti-Retroviral Agents; Benzoxazines; Cohort Studies; Cyclopropanes; Drug-Related Side Effects and Adverse Reactions; Exanthema; Female; HIV Infections; Humans; Incidence; Lamivudine; Male; Middle Aged; Nevirapine; Nigeria; Organophosphonates; Pain; Retrospective Studies; Risk Factors; Stavudine; Tenofovir; Zidovudine | 2012 |
[Hungarian consensus guideline for the diagnosis and treatment of B, C, and D viral hepatitis].
Topics: Adenine; Antiviral Agents; Comorbidity; Consensus; Drug Administration Schedule; Drug Therapy, Combination; Genotype; Guanine; Hepacivirus; Hepatitis B; Hepatitis C; Hepatitis D; Humans; Hungary; Interferon-alpha; Interferons; Lamivudine; Oligopeptides; Organophosphonates; Polyethylene Glycols; Proline; Recombinant Proteins; Ribavirin; RNA, Viral; Tenofovir; Time Factors; Treatment Outcome | 2012 |
Resistance profiles of emtricitabine and lamivudine in tenofovir-containing regimens.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; France; HIV; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Retrospective Studies; RNA, Viral; Selection, Genetic; Tenofovir; Treatment Failure; Viral Load | 2012 |
Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants.
Topics: Adenine; Anti-HIV Agents; Body Size; Child Development; Drug Therapy, Combination; Female; HIV Infections; Humans; Infant; Infant, Low Birth Weight; Infant, Newborn; Infant, Small for Gestational Age; Male; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Risk Factors; Tenofovir | 2012 |
Effects of 1α,25-dihydroxyvitamin D3 on transport and metabolism of adefovir dipivoxil and its metabolites in Caco-2 cells.
Topics: Adenine; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Cells, Cultured; Drug Interactions; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organophosphonates; Permeability; Verapamil; Vitamin D | 2012 |
L-selectin and P-selectin are novel biomarkers of cervicovaginal inflammation for preclinical mucosal safety assessment of anti-HIV-1 microbicide.
Topics: Adenine; Animals; Anti-Infective Agents; Benzalkonium Compounds; Biomarkers; Carboxymethylcellulose Sodium; Cervix Uteri; Chemokine CCL2; Female; HIV Infections; Inflammation; Interleukin-6; L-Selectin; Mice; Mice, Inbred C57BL; Mucous Membrane; Nonoxynol; Organophosphonates; P-Selectin; Sodium Dodecyl Sulfate; Tenofovir | 2012 |
Pharmacokinetics and topical vaginal effects of two tenofovir gels in rabbits.
Topics: Adenine; Administration, Intravaginal; Administration, Rectal; Animals; Anti-HIV Agents; Body Fluids; Female; HIV Infections; Lymph Nodes; Organophosphonates; Rabbits; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies | 2012 |
Renal function in patients with HIV starting therapy with tenofovir and either efavirenz, lopinavir or atazanavir.
Topics: Adenine; Adult; Alkynes; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Treatment Outcome | 2012 |
Safety of long-term nucleos(t)ide treatment in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Evidence-Based Medicine; Guanine; Hepatitis B, Chronic; Humans; Organophosphonates; Patient Safety; Risk Assessment; Risk Factors; Tenofovir; Time Factors; Treatment Outcome | 2012 |
Characterization of UC781-tenofovir combination gel products for HIV-1 infection prevention in an ex vivo ectocervical model.
Topics: Adenine; Anilides; Anti-HIV Agents; Anti-Retroviral Agents; Cervix Uteri; Chromatography, High Pressure Liquid; Female; Furans; Gels; HIV Infections; Humans; In Vitro Techniques; Organophosphonates; Tandem Mass Spectrometry; Tenofovir; Thioamides | 2012 |
Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings.
Topics: Adenine; Anti-Infective Agents; Antiviral Agents; Biocompatible Materials; Body Fluids; Contraceptive Devices, Female; Diffusion; Drug Delivery Systems; Female; HIV Infections; Humans; Microscopy, Electron, Scanning; Organophosphonates; Polyesters; Polymers; Polyvinyls; Tenofovir; Vagina | 2012 |
Discontinuation of Atripla as first-line therapy in HIV-1 infected individuals.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Anti-HIV Agents; California; Central Nervous System Diseases; Cohort Studies; Deoxycytidine; Depression; Dreams; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; Humans; Male; New Jersey; Organophosphonates; Oxazines; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Sleep Initiation and Maintenance Disorders | 2012 |
Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settings.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Adult; Africa; Anti-HIV Agents; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; Female; Health Resources; Humans; India; Lopinavir; Male; Medication Adherence; Middle Aged; Mutation; Organophosphonates; Patient Selection; Pilot Projects; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Surveys and Questionnaires; Tenofovir; Thailand; Treatment Failure; Viral Load | 2012 |
Lamivudine plus adefovir vs. entecavir in HBeAg-positive hepatitis B with sequential treatment failure of lamivudine and adefovir.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prognosis; Retrospective Studies; Treatment Failure | 2012 |
Fibroblast growth factor 23 in hypophosphataemic HIV-positive adults on tenofovir.
Topics: Adenine; Anti-HIV Agents; Calcium; Enzyme-Linked Immunosorbent Assay; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Glomerular Filtration Rate; HIV Seropositivity; Humans; Hypophosphatemia; Kidney Tubules, Proximal; Male; Middle Aged; Organophosphonates; Parathyroid Hormone-Related Protein; Phosphates; Tenofovir | 2012 |
[Prognosis analysis of hepatitis B virus recurrence after liver transplantation: a single-center study of 38 cases].
Topics: Adenine; Adult; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prognosis; Recurrence; Retrospective Studies | 2012 |
Intravaginal ring delivery of tenofovir disoproxil fumarate for prevention of HIV and herpes simplex virus infection.
Topics: Adenine; Antiviral Agents; Cell Culture Techniques; Chemoprevention; Contraceptive Devices, Female; Female; Herpes Genitalis; HIV; HIV Infections; Humans; Organ Culture Techniques; Organophosphonates; Simplexvirus; Tenofovir | 2012 |
The cost-effectiveness of pre-exposure prophylaxis for HIV infection in South African women.
Topics: Adenine; Adult; Anti-HIV Agents; Chemoprevention; Cost-Benefit Analysis; Female; HIV Infections; Humans; Incidence; Middle Aged; Organophosphonates; Survival Analysis; Tenofovir; Treatment Outcome | 2012 |
Cutaneous CD8+ T-cell infiltrates associated with human immunodeficiency virus.
Topics: Adenine; Alopecia; Anti-HIV Agents; Antigens, Differentiation, T-Lymphocyte; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; CD8-Positive T-Lymphocytes; Deoxycytidine; Diagnosis, Differential; Emtricitabine; HIV Infections; Humans; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Oligopeptides; Organophosphonates; Prednisone; Pseudolymphoma; Pyridines; Ritonavir; Skin; Tenofovir | 2012 |
[Evaluation of the safety of pregnancy initiated by chronic hepatitis B fathers while taking adefovir].
Topics: Adenine; Adult; Female; Hepatitis B, Chronic; Humans; Infant, Newborn; Male; Organophosphonates; Paternal Exposure; Pregnancy | 2012 |
Renal tubular dysfunction during long-term adefovir or tenofovir therapy in chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biomarkers; Creatinine; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney Tubules; Male; Middle Aged; Organophosphonates; Phosphates; Renal Insufficiency; Tenofovir; Time Factors; Uric Acid | 2012 |
Similar risk of renal events among patients treated with tenofovir or entecavir for chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; Creatinine; Female; Glomerular Filtration Rate; Guanine; Hepatitis B, Chronic; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Assessment; Tenofovir; Young Adult | 2012 |
Antiviral therapy against chronic hepatitis B in Brazil: high rates of lamivudine resistance mutations and correlation with HBV genotypes.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Cross-Sectional Studies; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Tenofovir; Viral Load; Young Adult | 2012 |
High efficacy of adefovir and entecavir combination therapy in patients with nucleoside-refractory hepatitis B.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates | 2012 |
Tenofovir disoproxil fumarate for prevention of vertical transmission of hepatitis B virus infection by highly viremic pregnant women: a case series.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Drug Administration Routes; Female; Hepatitis B; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Organophosphonates; Phosphorous Acids; Pregnancy; Retrospective Studies; Viremia | 2012 |
Renal toxicity of long-term therapy with tenofovir in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Dideoxynucleosides; Disease Progression; Female; Follow-Up Studies; Glomerular Filtration Rate; HIV Infections; Hospitals, Veterans; Humans; Incidence; Kidney; Male; Middle Aged; New York City; Organophosphonates; Outpatient Clinics, Hospital; Pilot Projects; Proportional Hazards Models; Renal Insufficiency, Chronic; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Thermosensitive hydrogel of hydrophobically-modified methylcellulose for intravaginal drug delivery.
Topics: Adenine; Administration, Intravaginal; Animals; Anti-HIV Agents; Cells, Cultured; Delayed-Action Preparations; Diffusion; Female; Hot Temperature; Hydrogels; Hydrophobic and Hydrophilic Interactions; Materials Testing; Methylcellulose; Organophosphonates; Rabbits; Tenofovir; Vaginosis, Bacterial | 2012 |
The elvitegravir Quad pill: the first once-daily dual-target anti-HIV tablet.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Carbamates; Clinical Trials as Topic; Deoxycytidine; Drug Administration Schedule; Drug Combinations; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Quinolones; Tablets; Thiazoles | 2012 |
Reformulated tenofovir gel for use as a dual compartment microbicide.
Topics: Adenine; Anti-HIV Agents; Anti-Infective Agents; Disease Transmission, Infectious; Female; HIV Infections; HIV-1; Humans; Organ Culture Techniques; Organophosphonates; Rectum; Tenofovir; Treatment Outcome; Vagina; Vaginal Creams, Foams, and Jellies | 2012 |
Commentary: combination therapy with two nucleos(t)ide analogues in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Factors influencing inadequate or suboptimal response to adefovir with or without genotypic resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Phylogeny; RNA-Directed DNA Polymerase; Treatment Failure | 2012 |
Does maternal use of tenofovir during pregnancy affect growth of HIV-exposed uninfected infants?
Topics: Adenine; Anti-HIV Agents; Body Size; Female; HIV Infections; Humans; Infant, Newborn; Male; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir | 2012 |
E2F1-dependent pathways are involved in amonafide analogue 7-d-induced DNA damage, G2/M arrest, and apoptosis in p53-deficient K562 cells.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Apoptotic Protease-Activating Factor 1; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Caffeine; Cell Cycle Proteins; Comet Assay; Cyclin-Dependent Kinase Inhibitor p21; DNA Breaks, Double-Stranded; Dose-Response Relationship, Drug; E2F1 Transcription Factor; Flow Cytometry; G2 Phase Cell Cycle Checkpoints; Gene Knockout Techniques; HCT116 Cells; HeLa Cells; Hep G2 Cells; Humans; Inhibitory Concentration 50; K562 Cells; M Phase Cell Cycle Checkpoints; MCF-7 Cells; Naphthalimides; Organophosphonates; Protein Serine-Threonine Kinases; Rats; Signal Transduction; Time Factors; Tumor Suppressor Protein p53 | 2012 |
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.
Topics: Adenine; Anti-HIV Agents; Cyclobutanes; Deoxyadenine Nucleotides; DNA Primers; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Mutation; Nucleic Acid Amplification Techniques; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Case report of cytomegalovirus retinitis in an HIV-positive patient with a CD4-count nadir of 254 cells per μl.
Topics: Adenine; Administration, Oral; Adult; Alkynes; Anti-HIV Agents; Aqueous Humor; Benzoxazines; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cyclopropanes; Cytomegalovirus; Cytomegalovirus Retinitis; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Male; Organophosphonates; Polymerase Chain Reaction; Tenofovir; Visual Acuity | 2012 |
Stress studies of tenofovir disoproxil fumarate by HPTLC in bulk drug and pharmaceutical formulation.
Topics: Adenine; Chloroform; Chromatography, High Pressure Liquid; Drug Stability; Hydrolysis; Methanol; Organophosphonates; Oxidation-Reduction; Pharmaceutical Preparations; Photolysis; Reproducibility of Results; Sensitivity and Specificity; Tablets; Tenofovir; Ultraviolet Rays | 2012 |
Antiretroviral prophylaxis for HIV prevention reaches a key milestone.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; Humans; Organophosphonates; Tenofovir | 2012 |
Pharmacokinetic profiling of efavirenz-emtricitabine-tenofovir fixed dose combination in pregnant and non-pregnant rats.
Topics: Adenine; Administration, Oral; Amniotic Fluid; Animals; Anti-HIV Agents; Chromatography, High Pressure Liquid; Deoxycytidine; Dose-Response Relationship, Drug; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; Fetus; HIV Infections; Infectious Disease Transmission, Vertical; Maternal-Fetal Exchange; Organophosphonates; Oxazines; Placenta; Pregnancy; Rats, Sprague-Dawley; Tissue Distribution | 2012 |
Patient-reported symptoms on the antiretroviral regimen efavirenz/emtricitabine/tenofovir.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cohort Studies; Cross-Sectional Studies; Cyclopropanes; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Health Status; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Quality of Life; Severity of Illness Index; Tenofovir; Treatment Outcome; Veterans | 2012 |
An intravaginal ring for the simultaneous delivery of multiple drugs.
Topics: Acyclovir; Adenine; Administration, Intravaginal; Animals; Antiviral Agents; Delayed-Action Preparations; Drug Delivery Systems; Equipment Design; Female; HIV; HIV Infections; Humans; Organophosphonates; Reverse Transcriptase Inhibitors; Silicon; Tenofovir; Tensile Strength | 2012 |
Hepatitis B prophylaxis post liver transplantation with newer nucleos(t)ide analogues after hepatitis B immunoglobulin discontinuation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Nucleotides; Organophosphonates; Secondary Prevention; Tenofovir; Treatment Outcome; Young Adult | 2012 |
The deleterious influence of tenofovir-based therapies on the progression of atherosclerosis in HIV-infected patients.
Topics: Adenine; Atherosclerosis; Chemokine CCL2; HIV Infections; Interleukin-6; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Impact of antiretroviral dosing frequency and pill burden on adherence among newly diagnosed, antiretroviral-naive HIV patients.
Topics: Adenine; Adult; Aged; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cohort Studies; Cyclopropanes; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Medication Adherence; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir | 2012 |
How good is "good enough"? The case for varying standards of evidence according to need for new interventions in HIV prevention.
Topics: Adenine; Administration, Intravaginal; Administration, Oral; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Ethical Analysis; Ethical Theory; Ethics, Research; Evidence-Based Medicine; Female; Gels; Guidelines as Topic; Health Services Accessibility; Health Services Needs and Demand; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Organophosphorus Compounds; Primary Prevention; Randomized Controlled Trials as Topic; Research Subjects; Sex Work; Tenofovir; Therapeutic Equipoise; United States; United States Food and Drug Administration | 2012 |
Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract.
Topics: Adenine; Adenosine Triphosphate; Anti-HIV Agents; Binding Sites; DNA Repair; HIV Reverse Transcriptase; HIV-1; Humans; Organophosphonates; Tenofovir | 2012 |
In vitro inhibition of HBV replication by a novel compound, GLS4, and its efficacy against adefovir-dipivoxil-resistant HBV mutations.
Topics: Adenine; Antiviral Agents; Capsid Proteins; DNA, Viral; Drug Resistance, Viral; Hep G2 Cells; Hepatitis B virus; Humans; Inhibitory Concentration 50; Mutation; Organophosphonates; Pyrimidines; Thiazoles; Viral Core Proteins; Virus Assembly; Virus Replication | 2012 |
Hepatitis B virus related membranous glomerulonephritis and proteinuria treated with lamivudine and tenofovir.
Topics: Adenine; Glomerulonephritis, Membranous; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Proteinuria; Reverse Transcriptase Inhibitors; Tenofovir; Young Adult | 2011 |
Renal function and incidence of chronic kidney disease in HIV patients: a Danish cohort study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Cohort Studies; Denmark; Female; Glomerular Filtration Rate; HIV Infections; Humans; Incidence; Kidney; Linear Models; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Renal Insufficiency, Chronic; Tenofovir | 2012 |
Solid lipid nanoparticles and nanosuspension of adefovir dipivoxil for bioavailability improvement: formulation, characterization, pharmacokinetic and biodistribution studies.
Topics: Adenine; Animals; Biological Availability; Calorimetry, Differential Scanning; Drug Carriers; Female; Lipids; Male; Mice; Microscopy, Electron, Transmission; Nanoparticles; Organophosphonates; Particle Size; Reverse Transcriptase Inhibitors; Solubility; X-Ray Diffraction | 2013 |
E138K and M184I mutations in HIV-1 reverse transcriptase coemerge as a result of APOBEC3 editing in the absence of drug exposure.
Topics: Adenine; Anti-HIV Agents; APOBEC Deaminases; Cytidine Deaminase; Cytosine Deaminase; DNA Mutational Analysis; Drug Resistance, Viral; Female; Glutamic Acid; HIV Reverse Transcriptase; HIV-1; Humans; Isoleucine; Lysine; Male; Methionine; Mutation; Nitriles; Organophosphonates; Pyridazines; Pyrimidines; Rilpivirine; Tenofovir; Treatment Failure; Virus Replication | 2012 |
[Influence of adefovir dipivoxil or telbivudine monotherapy on renal function of patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Creatinine; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Young Adult | 2012 |
Another drug in the armamentarium to combat hepatitis B virus in adolescents.
Topics: Adenine; Antiviral Agents; Female; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Tenofovir | 2012 |
Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Emtricitabine; Leukocytes, Mononuclear; Macaca mulatta; Male; Mutation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load; Zidovudine | 2012 |
Current practice of chronic hepatitis B treatment in Southern Italy.
Topics: Adenine; Adult; Age Factors; Aged; Aged, 80 and over; Antiviral Agents; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Italy; Lamivudine; Male; Middle Aged; Nucleosides; Organophosphonates; Polyethylene Glycols; Practice Patterns, Physicians'; Pyrimidinones; Recombinant Proteins; Telbivudine; Tenofovir; Thymidine; Young Adult | 2012 |
Efavirenz and psychosis: is there a link?
Topics: Adenine; Adult; Alkynes; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Male; Organophosphonates; Oxazines; Psychoses, Substance-Induced; Reverse Transcriptase Inhibitors | 2012 |
Sustained local delivery of structurally diverse HIV-1 microbicides released from sublimation enthalpy controlled matrices.
Topics: Adenine; Animals; Anti-HIV Agents; Cells, Cultured; Contraceptive Devices, Female; Delayed-Action Preparations; Deoxycytidine; Drug Delivery Systems; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Macrophages; Monocytes; Organophosphonates; Sheep; Structure-Activity Relationship; Sublimation, Chemical; T-Lymphocytes; Tenofovir | 2012 |
A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.
Topics: Adenine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cyclohexanes; Darunavir; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Flow Cytometry; Fluorescent Antibody Technique; Macaca mulatta; Maraviroc; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Simian Acquired Immunodeficiency Syndrome; Sulfonamides; T-Lymphocyte Subsets; Tenofovir; Triazoles; Viral Load; Viremia | 2012 |
High rate of K65R for antiretroviral therapy-naive patients with subtype C HIV infection failing a tenofovir-containing first-line regimen.
Topics: Adenine; Adult; Arginine; CD4 Lymphocyte Count; Cohort Studies; Drug Resistance, Viral; Female; HIV Reverse Transcriptase; HIV Seropositivity; HIV-1; Humans; Lamivudine; Lysine; Male; Mutation; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; South Africa; Stavudine; Tenofovir; Treatment Failure; Viral Load | 2012 |
Tenofovir in second-line ART in Zambia and South Africa: collaborative analysis of cohort studies.
Topics: Adenine; Adult; Africa South of the Sahara; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; South Africa; Tenofovir; Treatment Outcome; Viral Load; Zambia | 2012 |
Long-term hepatitis B virus surface antigen decay in HIV-1/hepatitis B virus-coinfected adults initiating a tenofovir-containing regimen.
Topics: Adenine; Adult; Anti-HIV Agents; Coinfection; Hepatitis B Surface Antigens; Hepatitis B, Chronic; HIV Infections; HIV-1; Humans; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load | 2012 |
Compared to subcutaneous tenofovir, oral tenofovir disoproxyl fumarate administration preferentially concentrates the drug into gut-associated lymphoid cells in simian immunodeficiency virus-infected macaques.
Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Drug Administration Schedule; Injections, Subcutaneous; Intestines; Lymphocytes; Macaca mulatta; Male; Organophosphonates; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome | 2012 |
Natural killer cell function in women at high risk for HIV acquisition: insights from a microbicide trial.
Topics: Adenine; Administration, Topical; Adult; Anti-HIV Agents; Case-Control Studies; CD4-Positive T-Lymphocytes; Cell Proliferation; Clinical Trials as Topic; Disease Susceptibility; Female; Flow Cytometry; Herpes Genitalis; HIV Seropositivity; HIV-1; Humans; Interferon-gamma; Interleukin-2; Killer Cells, Natural; Lymphocyte Activation; Middle Aged; Organophosphonates; Risk Assessment; Sexual Behavior; South Africa; Tenofovir; Vaginal Creams, Foams, and Jellies | 2012 |
Preexposure prophylaxis for HIV--where do we go from here?
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Pregnancy; Tenofovir | 2012 |
Clinical decisions. Preexposure prophylaxis for HIV prevention.
Topics: Adenine; Adolescent; Anti-Retroviral Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Safe Sex; Tenofovir | 2012 |
Five-year review of HIV-hepatitis B virus (HBV) co-infected patients in a New York City AIDS center.
Topics: Adenine; Adult; Anti-HIV Agents; Coinfection; Female; Hepatitis B; Hepatitis B e Antigens; HIV Infections; Humans; Liver Cirrhosis; Male; Middle Aged; New York City; Organophosphonates; Retrospective Studies; Tenofovir | 2012 |
The introduction of new antiretroviral-based HIV prevention methods into health systems: an update.
Topics: Adenine; Africa South of the Sahara; Anti-Retroviral Agents; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; Humans; Organophosphonates; Tenofovir; Vaginal Creams, Foams, and Jellies | 2012 |
Restored function of HBV-specific T cells after long-term effective therapy with nucleos(t)ide analogues.
Topics: Adenine; Antiviral Agents; Cells, Cultured; DNA, Viral; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-gamma; Interleukin-1; Lamivudine; Organophosphonates; T-Lymphocytes; Tenofovir; Tumor Necrosis Factor-alpha | 2012 |
Comparison of the efficacy of tenofovir and entecavir for the treatment of nucleos(t)ide-naive patients with chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome; Young Adult | 2012 |
Prevention. Using PrEP cost-effective in high-risk MSM groups.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Drug Costs; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Risk Factors; Tenofovir | 2012 |
Research. Fetuses unaffected by tenofovir, 1-year-olds appear slightly smaller.
Topics: Adenine; Female; Fetus; Growth; HIV Infections; Humans; Infant; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
Lamivudine or emtricitabine (XTC)/protease inhibitor dual therapy as a harm-reduction strategy in patients with tenofovir-related renal toxicity: a case-control study.
Topics: Adenine; Adult; Aged; Case-Control Studies; CD4 Lymphocyte Count; Chi-Square Distribution; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Kidney Diseases; Kidney Function Tests; Lamivudine; Male; Middle Aged; Organophosphonates; Protease Inhibitors; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2012 |
Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal.
Topics: Adenine; Alleles; Animals; Antibodies, Viral; Antibody Formation; Antiviral Agents; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Disease Models, Animal; Genes, MHC Class I; Genotyping Techniques; Immunity, Cellular; Lymphocyte Activation; Macaca mulatta; Neutralization Tests; Organophosphonates; RNA-Directed DNA Polymerase; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Treatment Outcome; Viremia; Virus Replication | 2012 |
Pharmacokinetics and pharmacodynamics of the reverse transcriptase inhibitor tenofovir and prophylactic efficacy against HIV-1 infection.
Topics: Adenine; Administration, Oral; Dose-Response Relationship, Drug; HIV Infections; HIV-1; Humans; Intracellular Space; Kinetics; Models, Biological; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2012 |
Double oral administration of emtricitabine/tenofovir prior to virus exposure protects against highly pathogenic simian/human immunodeficiency virus infection in macaques.
Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Antibiotic Prophylaxis; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine; Disease Models, Animal; Emtricitabine; Humans; Macaca; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Viral Load | 2012 |
Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.
Topics: Adenine; Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Emtricitabine; Immunity, Mucosal; Immunophenotyping; Injections, Subcutaneous; Macaca mulatta; Male; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; T-Lymphocyte Subsets; Tenofovir | 2012 |
Risk factors for chronic kidney disease in a large cohort of HIV-1 infected individuals initiating antiretroviral therapy in routine care.
Topics: Adenine; Adult; AIDS-Associated Nephropathy; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Creatinine; Female; Glomerular Filtration Rate; Hepatitis C; HIV Seropositivity; HIV-1; Humans; Incidence; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Renal Insufficiency, Chronic; Risk Factors; Ritonavir; Tenofovir; United States; Viral Load | 2012 |
Case report: management and HBV sequencing in a patient co-infected with HBV and HIV failing tenofovir.
Topics: Adenine; Anti-HIV Agents; Coinfection; Drug Resistance, Viral; Gene Products, pol; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Sequence Analysis, DNA; Tenofovir; Viral Load; Young Adult | 2012 |
Innate immune activation enhances hiv acquisition in women, diminishing the effectiveness of tenofovir microbicide gel.
Topics: Adenine; Adult; Anti-HIV Agents; Avian Proteins; Case-Control Studies; Coinfection; Cytokines; Disease Susceptibility; Female; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; Humans; Immunity, Innate; Logistic Models; Lymphocyte Activation; Organophosphonates; Platelet Count; Principal Component Analysis; Randomized Controlled Trials as Topic; Risk Factors; Tenofovir; Vaginal Creams, Foams, and Jellies; Young Adult | 2012 |
Acute liver failure resulting from discontinuation of nucleoside analogues in chronic hepatitis B patients: a report of two cases.
Topics: Adenine; Adult; Antiviral Agents; Guanine; Hepatitis B, Chronic; Histocytochemistry; Humans; Lamivudine; Liver Failure, Acute; Liver Transplantation; Male; Medication Adherence; Necrosis; Organophosphonates; Telbivudine; Thymidine | 2013 |
Trends in HIV-1 reverse transcriptase resistance-associated mutations and antiretroviral prescription data from 2003-2010.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Prescriptions; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Mutation; Organophosphonates; Prevalence; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Failure; Zidovudine | 2012 |
FDA paves the way for pre-exposure HIV prophylaxis.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Deoxycytidine; Drug Combinations; Emtricitabine; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Organophosphonates; Organophosphorus Compounds; Primary Prevention; Tenofovir; United States; United States Food and Drug Administration | 2012 |
Monitoring of HAART regime antiretrovirals in serum of acquired immunodeficiency syndrome patients by micellar liquid chromatography.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Chromatography, Liquid; Cyclopropanes; Drug Monitoring; Humans; Lamivudine; Organophosphonates; Stavudine; Tenofovir; Zidovudine | 2012 |
Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection.
Topics: Adenine; Administration, Topical; Animals; Anti-Infective Agents; Antiviral Agents; Cells, Cultured; Disease Models, Animal; Female; Herpes Genitalis; Interferon-gamma; Interleukin-2; Mice; Mice, Inbred C57BL; Organophosphonates; Tenofovir; Tumor Necrosis Factor-alpha; Vagina; Vaginal Creams, Foams, and Jellies; Virus Shedding | 2012 |
Tenofovir-associated proteinuria.
Topics: Adenine; Anti-HIV Agents; Creatine; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Proteinuria; Renal Insufficiency, Chronic; Tenofovir | 2013 |
Interim guidance for clinicians considering the use of preexposure prophylaxis for the prevention of HIV infection in heterosexually active adults.
Topics: Adenine; Administration, Oral; Adult; Anti-Retroviral Agents; Centers for Disease Control and Prevention, U.S.; Contraindications; Deoxycytidine; Drug Labeling; Emtricitabine; Female; Heterosexuality; HIV Infections; Homosexuality; Humans; Male; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Randomized Controlled Trials as Topic; Risk; Sexual Behavior; Tenofovir; United States | 2012 |
Chemico-physical investigation of tenofovir loaded polymeric nanoparticles.
Topics: Adenine; Anti-HIV Agents; Chitosan; Drug Carriers; Lactic Acid; Nanoparticles; Organophosphonates; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Tenofovir | 2012 |
Clinical, virological and biochemical evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing tenofovir/emtricitabine therapy.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Sequence Data; Mutation, Missense; Organophosphonates; Selection, Genetic; Sequence Analysis, DNA; Tenofovir; Treatment Failure | 2012 |
High rate of reversibility of renal damage in a cohort of HIV-infected patients receiving tenofovir-containing antiretroviral therapy.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Tenofovir; Time Factors; Withholding Treatment | 2012 |
Evolution of adefovir-resistant HBV polymerase gene variants after switching to tenofovir disoproxil fumarate monotherapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cloning, Molecular; DNA, Viral; Drug Resistance, Viral; Drug Substitution; Escherichia coli; Evolution, Molecular; Female; Follow-Up Studies; Gene Products, pol; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Tenofovir; Viremia | 2012 |
[A single tablet against HIV: new combination preparation improves therapy].
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Benzoxazines; Carbamates; CD4 Lymphocyte Count; Clinical Trials, Phase III as Topic; Cobicistat; Cyclopropanes; Deoxycytidine; Double-Blind Method; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Glomerular Filtration Rate; HIV Infections; Humans; Oligopeptides; Organophosphonates; Pyridines; Quinolones; Randomized Controlled Trials as Topic; Ritonavir; Tenofovir; Thiazoles; Viral Load | 2012 |
Macro CK2 accumulation in tenofovir-treated HIV patients is facilitated by CK oligomer stabilization but is not predictive for pathology.
Topics: Adenine; Anti-HIV Agents; Catalysis; Creatine Kinase, Mitochondrial Form; Enzyme Stability; Follow-Up Studies; Glomerular Filtration Rate; HIV Infections; Humans; Hypophosphatemia; Organophosphonates; Protein Multimerization; Tenofovir | 2013 |
Generic HIV drugs will widen US treatment net.
Topics: Adenine; Anti-HIV Agents; Budgets; Carbamates; Cost-Benefit Analysis; Deoxycytidine; Drug Combinations; Drug Costs; Drugs, Generic; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Federal Government; Humans; Organophosphonates; Oxazines; Patents as Topic; Quinolones; Thiazoles; United States | 2012 |
Cost-effectiveness of tenofovir instead of zidovudine for use in first-line antiretroviral therapy in settings without virological monitoring.
Topics: Adenine; Adult; Africa South of the Sahara; Anti-Retroviral Agents; Cost-Benefit Analysis; Drug Resistance, Viral; Epidemics; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Stochastic Processes; Tenofovir; Treatment Outcome; Zidovudine | 2012 |
Prolonged adefovir therapy associated Fanconi syndrome and interstitial nephritis in hepatitis B.
Topics: Adenine; Drug Administration Schedule; Fanconi Syndrome; Hepatitis B; Humans; Male; Middle Aged; Nephritis, Interstitial; Organophosphonates; Time Factors | 2012 |
Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report.
Topics: Adenine; Antiviral Agents; Arthroplasty, Replacement, Hip; Fanconi Syndrome; Femoral Neck Fractures; Hepatitis B, Chronic; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Organophosphonates; Osteomalacia; Predictive Value of Tests; Radiography; Radiopharmaceuticals; Treatment Outcome; Whole Body Imaging | 2012 |
A case of adefovir-induced membranous nephropathy related to hepatitis B caused by lamivudine-resistant virus after liver transplant due to Byler's disease.
Topics: Adenine; Adolescent; Adult; Child, Preschool; Cholestasis, Intrahepatic; Drug Resistance, Viral; Female; Glomerulonephritis, Membranous; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Organophosphonates | 2012 |
Is etravirine and two nucleosides an option for HIV with an isolated K103N mutation?
Topics: Adenine; Adult; Anti-HIV Agents; Asparagine; Deoxycytidine; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Emtricitabine; Female; Genotype; HIV Seropositivity; HIV-1; Humans; Lysine; Male; Mutation; Nitriles; Organophosphonates; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Tenofovir | 2013 |
Preexposure prophylaxis for the prevention of HIV transmission to women.
Topics: Adenine; Anti-HIV Agents; Chemoprevention; Cost-Benefit Analysis; Deoxycytidine; Directive Counseling; Emtricitabine; Family Characteristics; Female; HIV Infections; Humans; Male; Medication Adherence; Organophosphonates; Primary Health Care; Primary Prevention; Reproductive Behavior; Risk-Taking; Tenofovir; United States; United States Food and Drug Administration | 2013 |
Duration of first-line antiretroviral therapy with tenofovir and emtricitabine combined with atazanavir/ritonavir, efavirenz or lopinavir/ritonavir in the Italian ARCA cohort.
Topics: Adenine; Alkynes; Anti-Retroviral Agents; Atazanavir Sulfate; Benzoxazines; Cohort Studies; Cyclopropanes; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Italy; Longitudinal Studies; Lopinavir; Oligopeptides; Organophosphonates; Prospective Studies; Pyridines; Retrospective Studies; Ritonavir; Tenofovir; Time Factors | 2013 |
Emtricitabine/rilpivirine/tenofovir disoproxil fumarate single-tablet regimen: a guide to its use in HIV-1 infection.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; HIV-1; Humans; Nitriles; Organophosphonates; Patient Compliance; Pyrimidines; Rilpivirine; RNA, Viral; Tenofovir; Time Factors; Treatment Outcome | 2012 |
Does genotype predict response to treatment in children infected with hepatitis B perinatally?
Topics: Adenine; Adolescent; Anti-Inflammatory Agents; Antiviral Agents; Child; Child, Preschool; Clinical Trials as Topic; DNA, Viral; Genotype; Hepatitis B; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B virus; Humans; Interferons; Lamivudine; Organophosphonates; Prednisolone; Treatment Outcome | 2012 |
Hepatitis B e antigen predicts delayed reduction of HBV DNA without viral breakthrough with adefovir dipivoxil and lamivudine: a 5-year study of patients with hepatitis B with lamivudine resistance.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2012 |
FDA treads carefully with PrEP.
Topics: Adenine; Anti-HIV Agents; Chemoprevention; Deoxycytidine; Drug Approval; Drug Combinations; Drug Resistance, Viral; Emtricitabine; HIV Infections; Humans; Medication Adherence; Organophosphonates; Tenofovir; United States; United States Food and Drug Administration | 2012 |
Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure.
Topics: Adenine; Adult; Anti-HIV Agents; Blood Chemical Analysis; Chromatography, Liquid; Deoxycytidine; Desiccation; Emtricitabine; Erythrocytes; Female; Half-Life; HIV Infections; Humans; Leukocytes, Mononuclear; Male; Medication Adherence; Middle Aged; Organophosphonates; Plasma; Specimen Handling; Tandem Mass Spectrometry; Tenofovir; Young Adult | 2013 |
Safety and efficacy of adefovir therapy for lamivudine-resistant hepatitis B virus infection in renal transplant recipients.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Treatment Outcome | 2012 |
Safety and efficacy of tenofovir/IQP-0528 combination gels - a dual compartment microbicide for HIV-1 prevention.
Topics: Adenine; Administration, Mucosal; Anti-Infective Agents; Cell Line; Cell Survival; Chemoprevention; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Pyrimidinones; Tenofovir; Tissue Culture Techniques; Vaginal Creams, Foams, and Jellies | 2012 |
BND-12, a novel nonhaematotoxic naphthalimide derivative, inhibits tumour growth and metastasis of hepatocellular carcinoma.
Topics: Adenine; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Liver Neoplasms; Male; Mice; Mitochondria; Naphthalimides; Neoplasm Metastasis; Organophosphonates; Survival Rate; Toxicity Tests; Xenograft Model Antitumor Assays | 2012 |
Effect of tenofovir, an antiretroviral drug, on hepatic and renal functional indices of Wistar rats: protective role of vitamin E.
Topics: Adenine; Animals; Anti-HIV Agents; Antioxidants; Kidney; Kidney Function Tests; Liver; Liver Function Tests; Male; Malondialdehyde; Organophosphonates; Oxidative Stress; Rats; Rats, Wistar; Tenofovir; Vitamin E | 2012 |
Outcome of lamivudine-resistant chronic hepatitis B after up to 5 years of combination therapy with adefovir.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Statistics, Nonparametric; Time Factors; Treatment Outcome; Viremia; Young Adult | 2012 |
Tenofovir use and pregnancy among women initiating HAART.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; Follow-Up Studies; HIV Seropositivity; Humans; Infectious Disease Transmission, Vertical; Middle Aged; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Proportional Hazards Models; Prospective Studies; Risk Assessment; South Africa; Tenofovir; Treatment Outcome; Women's Health | 2012 |
Antiretroviral medications as prevention: will the new paradigm reverse the HIV epidemic?
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Epidemics; Female; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Randomized Controlled Trials as Topic; Risk Factors; Tenofovir | 2012 |
Differential effects of tenofovir/emtricitabine and abacavir/lamivudine on human leukocyte recruitment.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Cell Adhesion; Cell Adhesion Molecules; Cell Communication; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Endothelial Cells; HIV Infections; Humans; Lamivudine; Leukocytes; Organophosphonates; Tenofovir | 2012 |
Single nucleotide polymorphisms in ABCC2 associate with tenofovir-induced kidney tubular dysfunction in Japanese patients with HIV-1 infection: a pharmacogenetic study.
Topics: Adenine; Adult; Cohort Studies; Cross-Sectional Studies; Female; Genetic Predisposition to Disease; HIV Infections; HIV-1; Humans; Japan; Kidney Diseases; Kidney Tubules; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Polymorphism, Single Nucleotide; Tenofovir | 2012 |
Does interferon-sparing tenofovir disoproxil fumarate-based therapy have a role in the management of severe acute hepatitis delta superinfection?
Topics: Acute Disease; Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis D; Hepatitis Delta Virus; Humans; Interferons; Lamivudine; Male; Organophosphonates; RNA, Viral; Superinfection; Tenofovir; Young Adult | 2012 |
Comparison of rescue strategies in lamivudine-resistant patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; China; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Salvage Therapy; Treatment Outcome | 2012 |
Quantification of tenofovir in human plasma by solid-phase extraction and high-performance liquid chromatography coupled with UV detection.
Topics: Adenine; Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Female; HIV Infections; Humans; Male; Organophosphonates; Reference Standards; Reproducibility of Results; Solid Phase Extraction; Spectrophotometry, Ultraviolet; Tenofovir | 2012 |
Safety and pharmacokinetics of intravaginal rings delivering tenofovir in pig-tailed macaques.
Topics: Adenine; Administration, Intravaginal; Animals; Contraceptive Devices, Female; Cytokines; Delayed-Action Preparations; Female; Half-Life; Lymphocytes; Macaca nemestrina; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Vagina | 2012 |
A perspective on progress and gaps in HIV prevention science.
Topics: Adenine; Administration, Oral; Administration, Topical; Anal Canal; Anti-HIV Agents; Chemoprevention; Deoxycytidine; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; Humans; Immunity, Innate; Male; Medication Adherence; Mouth Mucosa; Mucous Membrane; Organophosphonates; Organophosphorus Compounds; Sexual Partners; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies | 2012 |
Risk factors and outcome of HIV-associated idiopathic noncirrhotic portal hypertension.
Topics: Adenine; Adult; Anti-HIV Agents; Case-Control Studies; Chemical and Drug Induced Liver Injury; Didanosine; Drug Therapy, Combination; Female; HIV Infections; Humans; Hypertension, Portal; Liver; Male; Middle Aged; Multivariate Analysis; Netherlands; Organophosphonates; Risk Factors; Stavudine; Tenofovir; Young Adult | 2012 |
Drug-induced acute interstitial nephritis mimicking acute tubular necrosis after initiation of tenofovir-containing antiretroviral therapy in patient with HIV-1 infection.
Topics: Acute Disease; Adenine; Aged; Anti-Retroviral Agents; Biopsy; Diagnosis, Differential; HIV Infections; HIV-1; Humans; Kidney; Kidney Tubular Necrosis, Acute; Male; Nephritis, Interstitial; Organophosphonates; Tenofovir | 2012 |
Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Drug Delivery Systems; Hydrophobic and Hydrophilic Interactions; Models, Theoretical; Organophosphonates; Polyurethanes; Reverse Transcriptase Inhibitors; Tenofovir | 2012 |
The effect of tenofovir on vitamin D metabolism in HIV-infected adults is dependent on sex and ethnicity.
Topics: Adenine; Adult; Anti-HIV Agents; Bone Density; Calcium; Cohort Studies; Ethnicity; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Parathyroid Hormone; Phosphates; Prospective Studies; Regression Analysis; Sex Factors; Tenofovir; Vitamin D | 2012 |
Evaluation of single and combination therapies with tenofovir disoproxil fumarate and emtricitabine in vitro and in a robust mouse model supporting high levels of hepatitis B virus replication.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Deoxycytidine; Drug Combinations; Drug Interactions; Emtricitabine; Hepatitis B; Hepatitis B virus; Mice; Mice, Nude; Organophosphonates; Phosphorylation; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Tenofovir; Viremia; Virus Replication | 2012 |
Coformer selection based on degradation pathway of drugs: a case study of adefovir dipivoxil-saccharin and adefovir dipivoxil-nicotinamide cocrystals.
Topics: Adenine; Antiviral Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Crystallization; Drug Stability; Niacinamide; Organophosphonates; Powder Diffraction; Prodrugs; Saccharin; Solubility; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; X-Ray Diffraction | 2012 |
Incidence of renal toxicity in HIV-infected, antiretroviral-naïve patients starting tenofovir/emtricitabine associated with efavirenz, atazanavir/ritonavir, or lopinavir/ritonavir.
Topics: Adenine; Adult; Alkynes; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Deoxycytidine; Emtricitabine; Female; Glomerular Filtration Rate; Glycosuria; HIV Infections; HIV Protease Inhibitors; Humans; Kidney Diseases; Lopinavir; Male; Middle Aged; Oligopeptides; Organophosphonates; Proteinuria; Pyridines; Retrospective Studies; Ritonavir; Tenofovir | 2013 |
Successful use of eltrombopag without splenectomy in refractory HIV-related immune reconstitution thrombocytopenia.
Topics: Adenine; Benzoates; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Seropositivity; Humans; Hydrazines; Immune Reconstitution Inflammatory Syndrome; Male; Middle Aged; Organophosphonates; Oxazines; Pyrazoles; Reverse Transcriptase Inhibitors; Thrombocytopenia; Treatment Outcome | 2012 |
Number of daily pills, dosing schedule, self-reported adherence and health status in 2010: a large cross-sectional study of HIV-infected patients on antiretroviral therapy.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Carbamates; CD4 Lymphocyte Count; Cross-Sectional Studies; Deoxycytidine; Dideoxynucleosides; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; Furans; HIV Infections; Humans; Italy; Lamivudine; Male; Medication Adherence; Middle Aged; Nevirapine; Oligopeptides; Organophosphates; Organophosphonates; Oxazines; Pyridines; Self Report; Sulfonamides; Surveys and Questionnaires; Viral Load | 2013 |
A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis.
Topics: Adenine; Administration, Intravaginal; Animals; Anti-HIV Agents; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Equipment Design; Female; HIV Infections; Irritants; Organophosphonates; Polyurethanes; Sheep; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies | 2012 |
2D solid-state NMR analysis of inclusion in drug-cyclodextrin complexes.
Topics: Adenine; Carbon Radioisotopes; Cyclodextrins; Diflunisal; Fluorine Radioisotopes; Hydrogen; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Organophosphonates; Phosphorus; Pyrimidines; Triazoles; Voriconazole | 2012 |
Tenofovir monotherapy and tenofovir plus entecavir combination as rescue therapy for entecavir partial responders.
Topics: Adenine; Adult; Analysis of Variance; Antiviral Agents; Chi-Square Distribution; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Liver Function Tests; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2012 |
Clinical decisions. Preexposure prophylaxis for HIV prevention--polling results.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; Humans; Male; Organophosphonates | 2012 |
Evaluation of anti-HBV drug resistant mutations among patients with acute symptomatic hepatitis B in the United States.
Topics: Acute Disease; Adenine; Adult; Antiviral Agents; Cohort Studies; Cross-Sectional Studies; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B; Humans; Lamivudine; Male; Mutation; Organophosphonates; Retrospective Studies; Sequence Analysis, DNA; United States | 2013 |
Genotype-specific mutations in the polymerase gene of hepatitis B virus potentially associated with resistance to oral antiviral therapy.
Topics: Adenine; Administration, Oral; Amino Acid Substitution; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Genes, pol; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Mutation Rate; Organophosphonates; Prevalence; Virus Replication | 2012 |
Decreasing population selection rates of resistance mutation K65R over time in HIV-1 patients receiving combination therapy including tenofovir.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Mutation, Missense; Organophosphonates; Selection, Genetic; Tenofovir; Time Factors; Treatment Failure | 2013 |
Raltegravir central nervous system tolerability in clinical practice: results from a multicenter observational study.
Topics: Adenine; Anti-HIV Agents; Central Nervous System; Drug Administration Schedule; Drug Interactions; Female; HIV Infections; Humans; Male; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Treatment Outcome; Viral Load | 2012 |
Age-related differences in plasma and intracellular tenofovir concentrations in HIV-1-infected children, adolescents and adults.
Topics: Adenine; Adolescent; Adult; Age Factors; Anti-HIV Agents; Biological Availability; Child; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tandem Mass Spectrometry; Tenofovir | 2013 |
The influence of HLA supertype on thymidine analogue associated with low peripheral fat in HIV.
Topics: Adenine; Anti-HIV Agents; Australia; Biomarkers; Blood Glucose; Body Fat Distribution; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Female; Genotype; HIV Infections; HIV-Associated Lipodystrophy Syndrome; HLA Antigens; HLA-A1 Antigen; HLA-B8 Antigen; HLA-DQ Antigens; Humans; Lamivudine; Linkage Disequilibrium; Male; Middle Aged; Multicenter Studies as Topic; Organophosphonates; Predictive Value of Tests; Randomized Controlled Trials as Topic; Tenofovir; Thymidine | 2012 |
Increased time exposure to tenofovir is associated with a greater decrease in estimated glomerular filtration rate in HIV patients with kidney function of less than 60 ml/min/1.73 m2.
Topics: Adenine; Anti-HIV Agents; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Failure, Chronic; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Risk Factors; Tenofovir; Time Factors | 2012 |
Five-year on-treatment efficacy of lamivudine-, tenofovir- and tenofovir + emtricitabine-based HAART in HBV-HIV-coinfected patients.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Coinfection; Deoxycytidine; Emtricitabine; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; HIV Infections; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome; Viral Load; Virus Replication | 2012 |
Blunted fetal growth by tenofovir in late pregnancy.
Topics: Adenine; Adult; Anti-HIV Agents; Asian People; Bone Density; Female; Fetal Growth Retardation; Hepatitis B; HIV Seropositivity; Humans; Infant, Newborn; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir | 2012 |
Coadministration of tenofovir decreased atazanavir plasma concentration after unilateral nephrectomy.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Drug Interactions; HIV Infections; Humans; Liver Function Tests; Male; Nephrectomy; Oligopeptides; Organophosphonates; Pyridines; Tenofovir | 2013 |
Microbicides are promoted as offering a 'female-controlled' HIV prevention method: so can they revolutionize the HIV crisis of young women in Kenya?
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Anti-Infective Agents; Awards and Prizes; Chemoprevention; Condoms; Condoms, Female; Female; HIV Infections; Humans; Incidence; Kenya; Middle Aged; Negotiating; Organophosphonates; Prevalence; Sexual Partners; Spouse Abuse; Tenofovir; Women's Health; Women's Rights; Young Adult | 2012 |
Long-term efficacy and safety of lamivudine, entecavir, and tenofovir for treatment of hepatitis B virus-related cirrhosis.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; Blood Chemical Analysis; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome; Turkey | 2013 |
The 2012 revised Dutch national guidelines for the treatment of chronic hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Drug Approval; Drug Resistance, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Infectious Disease Transmission, Vertical; Lamivudine; Milk, Human; Netherlands; Nucleosides; Organophosphonates; Practice Guidelines as Topic; Pregnancy; Pregnancy Complications, Infectious; Renal Insufficiency; Telbivudine; Tenofovir; Thymidine | 2012 |
Letter: renal tubular dysfunction during nucleotide analogue therapy in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Renal Insufficiency | 2012 |
Tenofovir-based regimens associated with less drug resistance in HIV-1-infected Nigerians failing first-line antiretroviral therapy.
Topics: Adenine; Adult; Cross-Sectional Studies; Drug Administration Schedule; Drug Resistance, Viral; Female; Genotype; HIV Seropositivity; HIV-1; Humans; Male; Mutation, Missense; Nigeria; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; RNA, Viral; Tenofovir; Treatment Failure; Viral Load; Zidovudine | 2013 |
[Preexposure prophylaxis for HIV infection--current data and recommendations].
Topics: Adenine; Africa; Anti-HIV Agents; Controlled Clinical Trials as Topic; Deoxycytidine; Drug Resistance, Viral; Early Termination of Clinical Trials; Emtricitabine; Female; HIV Infections; Humans; Male; Organophosphonates; Risk Factors; Tenofovir | 2012 |
Multidrug-resistant hepatitis B virus resulting from sequential monotherapy with lamivudine, adefovir, and entecavir: clonal evolution during lamivudine plus adefovir therapy.
Topics: Adenine; Adult; Antiviral Agents; Clonal Evolution; DNA, Viral; Drug Resistance, Multiple, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; RNA-Directed DNA Polymerase | 2013 |
Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice.
Topics: Adenine; Adult; Animals; Antiviral Agents; Disease Models, Animal; DNA, Viral; Female; Flow Cytometry; Hepatitis B Antibodies; Hepatitis B virus; Hepatitis B, Chronic; Histocompatibility Antigens Class I; Humans; Immunohistochemistry; Immunosuppressive Agents; Killer Cells, Natural; Male; Mice; Mice, Inbred C57BL; NK Cell Lectin-Like Receptor Subfamily C; Organophosphonates; Viral Load | 2013 |
Tenofovir diphosphate and emtricitabine triphosphate concentrations in blood cells compared with isolated peripheral blood mononuclear cells: a new measure of antiretroviral adherence?
Topics: Adenine; Adult; Anti-HIV Agents; Blood Cells; Deoxycytidine; Diphosphates; Emtricitabine; Female; HIV Infections; Humans; Leukocytes, Mononuclear; Male; Medication Adherence; Middle Aged; Organophosphonates; Polyphosphates; Tenofovir | 2013 |
Inefficient vaginal transmission of tenofovir-resistant HIV-1.
Topics: Adenine; Animals; Anti-HIV Agents; Disease Models, Animal; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Mice; Mucous Membrane; Mutation, Missense; Organophosphonates; Suppression, Genetic; Tenofovir; Vagina | 2013 |
Lower healthcare costs associated with the use of a single-pill ARV regimen in the UK, 2004-2008.
Topics: Adenine; Adult; Anti-Retroviral Agents; CD4 Lymphocyte Count; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; Health Care Costs; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Organophosphorus Compounds; Oxazines; Proportional Hazards Models; United Kingdom; Viral Load | 2012 |
Effect of nucleos(t)ide analogue therapy on hepatocarcinogenesis in chronic hepatitis B patients: a propensity score analysis.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; alpha-Fetoproteins; Antiviral Agents; Child; Child, Preschool; Female; Follow-Up Studies; Guanine; Hepatitis B Core Antigens; Hepatitis B, Chronic; Humans; Incidence; Lamivudine; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Proportional Hazards Models | 2013 |
[Clinical analysis of hepatitis B virus mutations related to adefovir dipivoxil among patients with chronic hepatitis B virus infection in eastern Zhejiang province].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Young Adult | 2012 |
Association between tenofovir exposure and reduced kidney function in a cohort of HIV-positive patients: results from 10 years of follow-up.
Topics: Adenine; Adult; Anti-HIV Agents; Canada; Cohort Studies; Female; Follow-Up Studies; Glomerular Filtration Rate; HIV Infections; HIV Seropositivity; Humans; Kidney Diseases; Male; Organophosphonates; Proportional Hazards Models; Tenofovir | 2013 |
FDA approves new 4-drug once-a-day HIV treatment.
Topics: Adenine; Carbamates; Cobicistat; Deoxycytidine; Drug Administration Schedule; Drug Approval; Drug Combinations; Emtricitabine; HIV Infections; Humans; Organophosphonates; Quinolones; Tenofovir; Thiazoles; United States; United States Food and Drug Administration | 2012 |
Severe acute hepatitis B in a treatment-naïve patient with antiviral drug resistant mutations in the polymerase gene.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Hepatitis B; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Italy; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Telbivudine; Tenofovir; Thailand; Thymidine; Travel; Treatment Outcome | 2013 |
In vitro and ex vivo inhibition of human telomerase by anti-HIV nucleoside reverse transcriptase inhibitors (NRTIs) but not by non-NRTIs.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cell Line; Cyclopropanes; Didanosine; Dideoxynucleosides; DNA Primers; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Stavudine; Telomerase; Tenofovir; Zidovudine | 2012 |
The efficacy of adefovir plus entecavir combination therapy in patients with chronic hepatitis B refractory to both lamivudine and adefovir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Failure | 2013 |
A 4-drug combination (Stribild) for HIV.
Topics: Adenine; Anti-HIV Agents; Carbamates; Clinical Trials as Topic; Cobicistat; Deoxycytidine; Double-Blind Method; Drug Approval; Drug Combinations; Drug Interactions; Drug Resistance, Multiple, Viral; Emtricitabine; HIV; HIV Infections; Humans; Organophosphonates; Quinolones; Randomized Controlled Trials as Topic; Tenofovir; Thiazoles; United States; United States Food and Drug Administration | 2012 |
HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genetic Variation; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Middle Aged; Molecular Sequence Data; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir | 2013 |
The short-term efficacy of entecavir in lamivudine-resistant chronic hepatitis B: influence of sequential adefovir-refractoriness.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2013 |
HIV-2 antiviral potency and selection of drug resistance mutations by the integrase strand transfer inhibitor elvitegravir and NRTIs emtricitabine and tenofovir in vitro.
Topics: Adenine; Base Sequence; Deoxycytidine; DNA Primers; Drug Resistance, Viral; Emtricitabine; HEK293 Cells; HIV Integrase Inhibitors; HIV-2; Humans; In Vitro Techniques; Mutation; Organophosphonates; Polymerase Chain Reaction; Quinolones; Reverse Transcriptase Inhibitors; Tenofovir | 2013 |
Treatment of lamivudine-resistant chronic hepatitis B infection: a multicenter retrospective study.
Topics: Adenine; Adult; Antiviral Agents; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Logistic Models; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Treatment Outcome; Viral Load | 2013 |
Renal impairment in patients receiving a tenofovir-cART regimen: impact of tenofovir trough concentration.
Topics: Adenine; Adult; Female; Glomerular Filtration Rate; Humans; Kidney; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Rwanda; Tenofovir | 2013 |
Clonal evolution of hepatitis B virus polymerase gene mutations during lamivudine-adefovir combination treatment.
Topics: Adenine; Adult; Antiviral Agents; Clonal Evolution; Drug Combinations; Drug Resistance, Viral; Drug Substitution; Gene Products, pol; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphates; Organophosphonates; Phenotype; Time Factors; Treatment Outcome | 2012 |
Selectivity of kinases on the activation of tenofovir, an anti-HIV agent.
Topics: Adenine; Adenosine Diphosphate; Anti-HIV Agents; Binding Sites; Molecular Docking Simulation; Organophosphonates; Phosphorylation; Protein Conformation; Protein Kinases; Tenofovir | 2013 |
Binding sensitivity of adefovir to the polymerase from different genotypes of HBV: molecular modeling, docking and dynamics simulation studies.
Topics: Adenine; Amino Acid Sequence; Antiviral Agents; DNA-Directed DNA Polymerase; Genotype; Hepatitis B; Hepatitis B virus; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Mutation; Organophosphonates; Sequence Alignment; Thermodynamics | 2013 |
[Assessment of mitochondrial toxicity induced by zidovudine and adefovir dipivoxil in rats].
Topics: Adenine; Animals; DNA, Mitochondrial; Electron Transport Complex IV; Female; Kidney; Liver; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Mitochondria, Muscle; Muscle, Skeletal; Myocardium; Organophosphonates; Rats; Rats, Sprague-Dawley; Zidovudine | 2012 |
Long-term hepatitis B surface antigen (HBsAg) kinetics during nucleoside/nucleotide analogue therapy: finite treatment duration unlikely.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Lamivudine; Longitudinal Studies; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Tenofovir | 2013 |
Role of drug efflux and uptake transporters in atazanavir intestinal permeability and drug-drug interactions.
Topics: Adenine; Animals; Anti-HIV Agents; Atazanavir Sulfate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Interactions; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Oligopeptides; Organic Anion Transporters; Organophosphonates; Permeability; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Tenofovir | 2013 |
Absence of liver steatosis in HIV-HCV co-infected patients receiving regimens containing tenofovir or abacavir.
Topics: Adenine; Adult; Anti-HIV Agents; Coinfection; Dideoxynucleosides; Fatty Liver; Female; Genotype; Hepatitis C; HIV Infections; Humans; Liver; Male; Multivariate Analysis; Organophosphonates; Prevalence; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir | 2013 |
Elvitegravir/cobicistat, mirabegron, and linaclotide.
Topics: Acetanilides; Adenine; Anti-Retroviral Agents; Carbamates; Constipation; Deoxycytidine; Drug Combinations; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; HIV-1; Humans; Organophosphonates; Peptides; Quinolones; Thiazoles; Urinary Bladder, Overactive | 2012 |
[Outcomes of unexpected pregnancy during anti-hepatitis B virus therapy with adefovir dipivoxil: a report on safety and full-term infants].
Topics: Adenine; Adult; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Infant, Newborn; Male; Organophosphonates; Pregnancy; Pregnancy Trimesters | 2012 |
Novel HIV-1 treatment Stribild™ gains regulatory approval.
Topics: Adenine; Anti-HIV Agents; Carbamates; Deoxycytidine; Drug Approval; Drug Combinations; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV; HIV Infections; Humans; Organophosphonates; Quinolones; Thiazoles | 2012 |
Scar undone: long-term therapy of hepatitis B.
Topics: Adenine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2013 |
Improved adherence expected with new HIV combo treatment.
Topics: Adenine; Aged; Aged, 80 and over; Anti-HIV Agents; Carbamates; Deoxycytidine; Drug Combinations; Drug Labeling; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Medication Adherence; Middle Aged; Organophosphonates; Quinolones; Randomized Controlled Trials as Topic; Thiazoles; United States | 2012 |
Simultaneous analysis of antiretroviral drugs abacavir and tenofovir in human hair by liquid chromatography-tandem mass spectrometry.
Topics: Adenine; Anti-Retroviral Agents; Chromatography, Liquid; Dideoxynucleosides; Hair; Humans; Organophosphonates; Tandem Mass Spectrometry; Tenofovir | 2013 |
[Efficacy and tolerance of tenofovir-lamivudine-efavirenz combination in HIV-1 patients in Fann Teaching Hospital in Dakar].
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Hospitals, Teaching; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Senegal; Tenofovir; Treatment Outcome | 2013 |
Early viral suppression predicts good postoperative survivals in patients with hepatocellular carcinoma with a high baseline HBV-DNA load.
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; Disease-Free Survival; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Organophosphonates; Portal Vein; Proportional Hazards Models; Retrospective Studies; Risk Factors; Viral Load | 2013 |
Management of chronic hepatitis B: Canadian Association for the Study of the Liver consensus guidelines.
Topics: Adenine; Allied Health Personnel; Antibodies, Viral; Antiviral Agents; Canada; Coinfection; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C; Humans; Interferons; Kidney Diseases; Liver; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir | 2012 |
Tenofovir treatment duration predicts proteinuria in a multiethnic United States Cohort of children and adolescents with perinatal HIV-1 infection.
Topics: Adenine; Adolescent; Anti-HIV Agents; Black or African American; Child; Cohort Studies; Female; Hispanic or Latino; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Male; Multivariate Analysis; Odds Ratio; Organophosphonates; Prevalence; Prospective Studies; Proteinuria; Renal Insufficiency, Chronic; Statistics, Nonparametric; Tenofovir; United States | 2013 |
Tenofovir use and urinary biomarkers among HIV-infected women in the Women's Interagency HIV Study (WIHS).
Topics: Acetylglucosaminidase; Acute-Phase Proteins; Adenine; Adult; beta 2-Microglobulin; Biomarkers; Female; HIV Infections; Humans; Lipocalin-2; Lipocalins; Middle Aged; Organophosphonates; Prospective Studies; Proto-Oncogene Proteins; Reverse Transcriptase Inhibitors; Tenofovir | 2013 |
Impact of pharmacogenetic markers of CYP2B6, clinical factors, and drug-drug interaction on efavirenz concentrations in HIV/tuberculosis-coinfected patients.
Topics: Adenine; Adolescent; Adult; Alkynes; Anti-HIV Agents; Antitubercular Agents; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Cyclopropanes; Cytochrome P-450 CYP2B6; Drug Interactions; Ethambutol; Female; Genotype; HIV Infections; Humans; Isoniazid; Lamivudine; Male; Middle Aged; Organophosphonates; Oxidoreductases, N-Demethylating; Pharmacogenetics; Polymorphism, Single Nucleotide; Pyrazinamide; Reverse Transcriptase Inhibitors; Rifampin; Tenofovir; Tuberculosis; Young Adult | 2013 |
The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir.
Topics: Adenine; Amino Acid Substitution; Animals; Antiviral Agents; Computational Biology; Disease Models, Animal; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B virus; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Mutant Proteins; Organophosphonates; RNA-Directed DNA Polymerase; Tenofovir | 2013 |
Cellular pharmacology and potency of HIV-1 nucleoside analogs in primary human macrophages.
Topics: Adenine; Anti-HIV Agents; Biological Transport; HIV Integrase Inhibitors; HIV-1; Humans; Lymphocytes; Macrophage Activation; Macrophage Colony-Stimulating Factor; Macrophages; Organ Specificity; Organophosphonates; Primary Cell Culture; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Tenofovir | 2013 |
Osteomalacia due to Fanconi's syndrome and renal failure caused by long-term low-dose adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Osteomalacia; Renal Insufficiency | 2013 |
Experience of anti-viral therapy in hepatitis B-associated membranous nephropathy, including Lamivudine-resistant strains.
Topics: Adenine; Adult; Antiviral Agents; Arabinofuranosyluracil; Drug Resistance, Viral; Female; Glomerulonephritis, Membranous; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
Coverage, context and targeted prevention: optimising our impact.
Topics: Adenine; Anti-HIV Agents; Circumcision, Male; Deoxycytidine; Emtricitabine; Female; Health Priorities; HIV Infections; Humans; Male; Organophosphonates; Sexual Behavior; Tenofovir; United States; Vaginal Creams, Foams, and Jellies | 2013 |
The effect of HLA-DQB1 alleles on virologic breakthroughs during chronic hepatitis B treatment with genetically low barrier drugs.
Topics: Adenine; Adult; Alleles; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; HLA-DQ beta-Chains; Humans; Lamivudine; Male; Organophosphonates; RNA, Viral | 2013 |
Spray drying tenofovir loaded mucoadhesive and pH-sensitive microspheres intended for HIV prevention.
Topics: Adenine; Cell Survival; Chemistry, Pharmaceutical; Drug Carriers; HIV Infections; Humans; Hydrogen-Ion Concentration; Microspheres; Organophosphonates; Particle Size; Tenofovir | 2013 |
Tenofovir, emtricitabine intracellular and plasma, and efavirenz plasma concentration decay following drug intake cessation: implications for HIV treatment and prevention.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Deoxycytidine; Drug Combinations; Emtricitabine; Female; Half-Life; HIV Infections; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Organophosphonates; Tandem Mass Spectrometry; Tenofovir; Young Adult | 2013 |
Antiretroviral preexposure prophylaxis for HIV prevention.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates | 2013 |
Antiretroviral preexposure prophylaxis for HIV prevention.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates | 2013 |
Antiretroviral preexposure prophylaxis for HIV prevention.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Pregnancy | 2013 |
Antiretroviral preexposure prophylaxis for HIV prevention.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Pregnancy | 2013 |
Antiretroviral preexposure prophylaxis for HIV prevention.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Organophosphonates | 2013 |
Drug updates and approvals: 2012 in review.
Topics: Acetanilides; Adenine; Antibodies, Monoclonal, Humanized; Benzazepines; Carbamates; Cobicistat; Deoxycytidine; Drug Approval; Drug Combinations; Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Emtricitabine; Fatty Alcohols; Humans; Mifepristone; Nicotinic Acids; Nurse Practitioners; Organophosphonates; Phosphatidylglycerols; Prednisone; Proteins; Pyrimidines; Quinolones; Ranibizumab; Tenofovir; Thiazoles; United States; United States Food and Drug Administration | 2013 |
Should chronic hepatitis B be treated as early as possible?
Topics: Adenine; Adult; Antiviral Agents; Belgium; Cost-Benefit Analysis; Early Diagnosis; Guanine; Health Care Surveys; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Markov Chains; Middle Aged; Organophosphonates; Quality of Life; Secondary Prevention; Tenofovir; Treatment Outcome; Viral Load | 2013 |
Tenofovir plasma concentrations in post-menopausal versus pre-menopausal HIV-infected women.
Topics: Adenine; Adult; Anti-HIV Agents; Attention; Female; HIV Infections; Humans; Middle Aged; Organophosphonates; Plasma; Postmenopause; Premenopause; Tenofovir | 2013 |
Hepatitis B virus wild-type and rtN236T populations show similar early HBV DNA decline in adefovir refractory patients on a tenofovir-based regimen.
Topics: Adenine; Adult; Amino Acid Substitution; Antiviral Agents; Deoxycytidine; DNA, Viral; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; Female; Gene Products, pol; Genetic Association Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Male; Middle Aged; Molecular Typing; Organophosphonates; Polymerase Chain Reaction; Randomized Controlled Trials as Topic; Sequence Analysis, DNA; Tenofovir; Treatment Outcome; Viral Load; Virus Replication | 2013 |
Hepatitis B e antigen-suppressing mutations enhance the replication efficiency of adefovir-resistant hepatitis B virus strains.
Topics: Adenine; Antiviral Agents; Cell Line, Tumor; Drug Resistance, Viral; Gene Products, pol; Hepatitis B e Antigens; Hepatitis B virus; Humans; Mutation; Organophosphonates; Promoter Regions, Genetic; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2013 |
[Antiviral therapy for patients with chronic hepatitis B with multi-drug resistance to nucleoside analogues].
Topics: Adenine; Aged; Aged, 80 and over; Antiviral Agents; Drug Resistance, Multiple, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates | 2013 |
Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging.
Topics: Adenine; Adult; Aging; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Case-Control Studies; Cells, Cultured; Deoxycytidine; Dideoxynucleosides; Emtricitabine; Enzyme Activation; Female; HIV; HIV Infections; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Regression Analysis; Reverse Transcriptase Inhibitors; Risk Factors; Telomerase; Telomere; Telomere Shortening; Tenofovir; Time Factors; Young Adult; Zidovudine | 2013 |
Low prevalence of transmitted K65R and other tenofovir resistance mutations across different HIV-1 subtypes: implications for pre-exposure prophylaxis.
Topics: Adenine; Anti-HIV Agents; Drug Resistance, Viral; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Viral; Global Health; HIV Infections; HIV-1; Humans; Mutation; Organophosphonates; Population Surveillance; RNA-Directed DNA Polymerase; Tenofovir | 2012 |
Kinetics and prediction of HBsAg loss during therapy with analogues in patients affected by chronic hepatitis B HBeAg negative and genotype D.
Topics: Adenine; Aged; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2013 |
Patterns and causes of suboptimal response to tenofovir-based therapy in individuals coinfected with HIV and hepatitis B virus.
Topics: Adenine; Adult; Aged; Antiretroviral Therapy, Highly Active; Antiviral Agents; Australia; Coinfection; Deoxycytidine; DNA, Viral; Emtricitabine; Female; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Medication Adherence; Middle Aged; Organophosphonates; Tenofovir; Thailand; Treatment Failure; United States | 2013 |
Use of ALLGIO probe assays for detection of HBV resistance to adefovir in patients with chronic hepatitis B, Kerman, Iran.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biological Assay; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleic Acid Probes; Organophosphonates; Polymerase Chain Reaction; Retrospective Studies | 2012 |
Economic savings versus health losses: the cost-effectiveness of generic antiretroviral therapy in the United States.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cost-Benefit Analysis; Cyclopropanes; Deoxycytidine; Drug Combinations; Drugs, Generic; Emtricitabine; Female; HIV Infections; Humans; Male; Models, Theoretical; Organophosphonates; Quality-Adjusted Life Years; Reverse Transcriptase Inhibitors; Tenofovir; United States | 2013 |
Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Mutation; Organophosphonates; Probability; Retrospective Studies; Reverse Transcriptase Inhibitors; Time Factors; Treatment Outcome | 2012 |
Comparative buccal permeability enhancement of didanosine and tenofovir by potential multifunctional polymeric excipients and their effects on porcine buccal histology.
Topics: Acrylic Resins; Adenine; Administration, Buccal; Alginates; Animals; Anti-HIV Agents; Carboxymethylcellulose Sodium; Didanosine; Excipients; Glucuronic Acid; Hexuronic Acids; Mouth Mucosa; Organophosphonates; Permeability; Polyethylene Glycols; Swine; Tenofovir | 2014 |
Outcome of various treatments for posttransplant hepatitis B virus recurrence.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Biomarkers; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Recurrence; Retrospective Studies; Treatment Outcome; Young Adult | 2013 |
Prophylactic antiretroviral HIV therapy prevents infection in heterosexual men and women.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Pregnancy | 2013 |
Reactivation of occult hepatitis B virus infection following cytotoxic lymphoma therapy in an anti-HBc negative patient.
Topics: Adenine; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Antiviral Agents; DNA, Viral; Genotype; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunologic Factors; Lymphoma; Male; Organophosphonates; Papua New Guinea; Phylogeny; Rituximab; Sequence Analysis, DNA; Tenofovir; Viral Load; Virus Activation | 2013 |
HIV transmission may be prevented by intravaginal tenofovir ring.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Drug Delivery Systems; Female; HIV Infections; Humans; Organophosphonates; Tenofovir | 2012 |
Prevalence of pre-existing resistance-associated mutations to rilpivirine, emtricitabine and tenofovir in antiretroviral-naive patients infected with B and non-B subtype HIV-1 viruses.
Topics: Adenine; Antiretroviral Therapy, Highly Active; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Genotype; HIV Infections; HIV-1; Humans; Mutation; Nitriles; Organophosphonates; Prevalence; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir | 2013 |
Sexually transmitted infection with an immune-escape mutant hepatitis B virus in an hepatitis B virus-vaccinated individual with acute HIV-hepatitis C virus infection.
Topics: Acute Disease; Adenine; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Darunavir; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Hepatitis B; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis C; HIV Seropositivity; Homosexuality, Male; Humans; Male; Organophosphonates; Sulfonamides; Tenofovir; Treatment Outcome; Unsafe Sex; Viral Load | 2013 |
Comprehensive in vitro analysis of simian retrovirus type 4 susceptibility to antiretroviral agents.
Topics: Adenine; Amino Acid Sequence; Animals; Anti-Retroviral Agents; Genes, Reporter; Integrases; Luciferases; Microbial Sensitivity Tests; Organophosphonates; Protease Inhibitors; Retroviruses, Simian; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Alignment; Tenofovir; Zidovudine | 2013 |
ASN clinical pathological conference. Tenofovir-related ATN (severe).
Topics: Adenine; Anti-HIV Agents; Biopsy; Diagnosis, Differential; Glomerulonephritis, IGA; HIV Infections; Humans; Kidney Tubular Necrosis, Acute; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Risk Factors; Severity of Illness Index; Staphylococcal Infections; Tenofovir | 2013 |
Combination therapy efavirenz/emtricitabine/tenofovir disoproxil fumarate associated with hepatic failure.
Topics: Adenine; Adult; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; HIV Infections; Humans; Liver Failure; Male; Organophosphonates; Oxazines; Reverse Transcriptase Inhibitors | 2012 |
A ROS-mediated lysosomal-mitochondrial pathway is induced by a novel Amonafide analogue, 7c, in human Hela cervix carcinoma cells.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Dose-Response Relationship, Drug; HeLa Cells; Humans; Intracellular Membranes; Lysosomes; Membrane Potential, Mitochondrial; Mitochondria; Naphthalimides; Organophosphonates; Permeability; Reactive Oxygen Species | 2013 |
A model of HIV drug resistance driven by heterogeneities in host immunity and adherence patterns.
Topics: Adenine; Anti-HIV Agents; Computer Simulation; Drug Resistance, Viral; HIV Infections; Humans; Medication Adherence; Models, Immunological; Organophosphonates; Tenofovir; Viral Load | 2013 |
Efficacy of tenofovir in patients with Lamivudine failure is not different from that in nucleoside/nucleotide analogue-naive patients with chronic hepatitis B.
Topics: Adenine; Adult; Anti-HIV Agents; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Retrospective Studies; Tenofovir | 2013 |
Tenofovir plasma concentrations according to companion drugs: a cross-sectional study of HIV-positive patients with normal renal function.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Chromatography, Liquid; Cross-Sectional Studies; Female; HIV Infections; HIV Protease Inhibitors; Humans; Male; Mass Spectrometry; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir | 2013 |
Efficacy of combined antiviral therapy with lamivudine and tenofovir in a liver transplanted girl with de novo hepatitis B virus infection.
Topics: Adenine; Antiviral Agents; Child, Preschool; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Liver Transplantation; Organophosphonates; Tenofovir; Treatment Outcome | 2013 |
Efficient single tobamoviral vector-based bioproduction of broadly neutralizing anti-HIV-1 monoclonal antibody VRC01 in Nicotiana benthamiana plants and utility of VRC01 in combination microbicides.
Topics: Adenine; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Antiviral Agents; Chromatography, Affinity; Cyclohexanes; Drug Combinations; Drug Synergism; Genetic Vectors; HIV Antibodies; HIV Envelope Protein gp120; HIV-1; Humans; Immunoglobulin G; Maraviroc; Neutralization Tests; Nicotiana; Organophosphonates; Plant Lectins; Recombinant Proteins; Tenofovir; Tobamovirus; Triazoles | 2013 |
[Effects of adefovir dipivoxil on liver pathology in patients with chronic hepatitis B].
Topics: Adenine; Adolescent; Adult; Female; Hepatitis B, Chronic; Humans; Liver; Male; Middle Aged; Organophosphonates; Young Adult | 2012 |
Telbivudine plus adefovir therapy for chronic hepatitis B patients with virological breakthrough or genotypic resistance to telbivudine.
Topics: Adenine; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Phenotype; Telbivudine; Thymidine; Time Factors; Treatment Outcome; Viral Load; Virus Replication | 2013 |
High frequency of complex mutational patterns in lamivudine resistant hepatitis B virus isolates.
Topics: Adenine; Antiviral Agents; Codon, Nonsense; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Mutation, Missense; Organophosphonates; RNA-Directed DNA Polymerase | 2013 |
Development and validation of an assay for the simultaneous determination of zidovudine, abacavir, emtricitabine, lamivudine, tenofovir and ribavirin in human plasma using liquid chromatography-tandem mass spectrometry.
Topics: Adenine; Antiviral Agents; Chromatography, Liquid; Deoxyribonucleosides; Drug Stability; Humans; Linear Models; Organophosphonates; Reproducibility of Results; Ribavirin; Sensitivity and Specificity; Tandem Mass Spectrometry; Tenofovir | 2013 |
Hepatitis B therapy, hepatocellular carcinoma and HBsAg mutants.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Therapy, Combination; Hepatitis B; Hepatitis B Surface Antigens; Humans; Immunohistochemistry; Lamivudine; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Real-Time Polymerase Chain Reaction; Tomography, X-Ray Computed | 2013 |
Resolution of adefovir-related nephrotoxicity by adefovir dose-reduction in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Creatinine; Dose-Response Relationship, Drug; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates | 2013 |
Pharmacokinetics of two common antiretroviral regimens in older HIV-infected patients: a pilot study.
Topics: Adenine; Aged; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Black or African American; Cyclopropanes; Data Interpretation, Statistical; Deoxycytidine; Emtricitabine; Female; Frail Elderly; HIV; HIV Infections; Humans; Male; Middle Aged; Oligopeptides; Organophosphonates; Pilot Projects; Pyridines; Ritonavir; Tenofovir; White People | 2013 |
Resolution of chronic hepatitis delta infection after five years of peginterferon-adefovir: lessons from a case report.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Hepatitis D, Chronic; Hepatitis delta Antigens; Hepatitis Delta Virus; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; RNA, Viral | 2013 |
[Tenofovir hypersensitivity to tenofovir (DRESS) syndrome in a female patient infected by HIV].
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Asthenia; Benzoxazines; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Eruptions; Drug Hypersensitivity; Drug Substitution; Emtricitabine; Female; Fever; HIV Infections; Humans; Lamivudine; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Syndrome; Tenofovir | 2013 |
A different look at the management of chronic hepatitis B in a resource-constrained country.
Topics: Adenine; Antiviral Agents; China; Drug Therapy, Combination; Health Resources; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Telbivudine; Thymidine | 2013 |
Urinary beta-2 microglobulin and alpha-1 microglobulin are useful screening markers for tenofovir-induced kidney tubulopathy in patients with HIV-1 infection: a diagnostic accuracy study.
Topics: Adenine; Adult; Alpha-Globulins; Anti-Retroviral Agents; beta 2-Microglobulin; Biomarkers; Chi-Square Distribution; Female; HIV Infections; HIV-1; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Sensitivity and Specificity; Tenofovir | 2013 |
Bone scintigraphic findings of hypophosphatemic osteomalacia associated with adefovir therapy: involvement of lower extremity skeletons.
Topics: Adenine; Bone and Bones; Humans; Hypophosphatemia; Lower Extremity; Male; Middle Aged; Organophosphonates; Osteomalacia; Radionuclide Imaging | 2013 |
Individualized treatment of HBeAg-negative chronic hepatitis B using pegylated interferon-α2a as first-line and week-12 HBV DNA/HBsAg stopping rule: a cost-effectiveness analysis.
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; Cost-Benefit Analysis; Drug Administration Schedule; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Liver Cirrhosis; Liver Neoplasms; Male; Markov Chains; Organophosphonates; Polyethylene Glycols; Precision Medicine; Prognosis; Quality-Adjusted Life Years; Recombinant Proteins; Tenofovir; Viral Load | 2013 |
Prophylactic effect of antiretroviral therapy on hepatitis B virus infection.
Topics: Adenine; Adult; Alanine Transaminase; Anti-Retroviral Agents; Antibiotic Prophylaxis; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; HIV Infections; Humans; Kaplan-Meier Estimate; Lamivudine; Male; Organophosphonates; Retrospective Studies; Tenofovir | 2013 |
[Pulmonary hypertension in human immunodeficiency virus-infected patients: the role of antiretroviral therapy].
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cross-Sectional Studies; Drug Therapy, Combination; Female; HIV Infections; Humans; Hypertension, Pulmonary; Lamivudine; Male; Middle Aged; Organophosphonates; Prevalence; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Tricuspid Valve Insufficiency; Ultrasonography | 2014 |
Adefovir is effective to promote development of immunity to donor origin hepatitis B virus in an allogeneic transplant recipient: a case report.
Topics: Adenine; Adult; Alanine Transaminase; Anemia, Aplastic; Antiviral Agents; Aspartate Aminotransferases; Biomarkers; DNA, Viral; Donor Selection; Drug Resistance, Viral; Drug Therapy, Combination; Hematopoietic Stem Cell Transplantation; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunosuppressive Agents; Lamivudine; Living Donors; Male; Organophosphonates; Time Factors; Transplantation, Homologous; Treatment Outcome | 2013 |
Negligible effect of tenofovir on atazanavir trough concentrations and genotypic inhibitory quotients in the presence and absence of ritonavir.
Topics: Adenine; Adult; Atazanavir Sulfate; Drug Interactions; Drug Monitoring; Female; Genotype; HIV Protease Inhibitors; Humans; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Retrospective Studies; Ritonavir; Tenofovir; Viral Load | 2013 |
[Cost-effectiveness of nucleoside/nucleotide analogues in chronic hepatitis B].
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B, Chronic; Humans; Markov Chains; Models, Theoretical; Organophosphonates; Quality-Adjusted Life Years; Tenofovir | 2012 |
Characterization of the dynamics of hepatitis B virus resistance to adefovir by ultra-deep pyrosequencing.
Topics: Adenine; Adolescent; Adult; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Randomized Controlled Trials as Topic; Treatment Outcome; Young Adult | 2013 |
Increased eGFR with telbivudine in combination therapy of chronic hepatitis B infection.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Glomerular Filtration Rate; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Telbivudine; Tenofovir; Thymidine | 2014 |
Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy.
Topics: Adenine; Adult; AIDS-Associated Nephropathy; Anti-HIV Agents; HIV Infections; Humans; Organophosphonates; Sensitivity and Specificity; Specimen Handling; Tenofovir; Time Factors; Uric Acid | 2013 |
Renal dysfunction and hypophosphatemia during long-term lamivudine plus adefovir dipivoxil therapy in patients with chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Creatinine; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Hypophosphatemia; Incidence; Kidney Diseases; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Risk Factors; Time Factors | 2014 |
Cost-effectiveness of pre-exposure prophylaxis (PrEP) in preventing HIV-1 infections in rural Zambia: a modeling study.
Topics: Adenine; Anti-HIV Agents; Cost-Benefit Analysis; Deoxycytidine; Emtricitabine; HIV Infections; HIV-1; Humans; Models, Biological; Organophosphonates; Prevalence; Primary Prevention; Rural Population; Sensitivity and Specificity; Sexual Behavior; Tenofovir; Zambia | 2013 |
Rectal transmission of transmitted/founder HIV-1 is efficiently prevented by topical 1% tenofovir in BLT humanized mice.
Topics: Adenine; Administration, Rectal; Animals; Anti-HIV Agents; Antigens, CD34; Drug Evaluation, Preclinical; Female; Hepatocytes; HIV Infections; HIV-1; Humans; Kaplan-Meier Estimate; Male; Mice; Mice, Transgenic; Organophosphonates; Rectum; Sequence Analysis, DNA; Tenofovir | 2013 |
Boosting HIV treatment options: good news, new challenges.
Topics: Adenine; Anti-HIV Agents; Atazanavir Sulfate; Carbamates; Cobicistat; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; Humans; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir; Thiazoles | 2013 |
Prevention of de novo hepatitis B with adefovir plus vaccination in recipients of liver transplants from core antibody-positive donors.
Topics: Adenine; Adult; Aged; Antiviral Agents; Biomarkers; Deoxycytidine; DNA, Viral; Drug Substitution; Emtricitabine; Guanine; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Vaccines; Hepatitis B virus; Humans; Liver Transplantation; Middle Aged; Organophosphonates; Tenofovir; Time Factors; Tissue Donors; Treatment Outcome | 2013 |
Prevention of de novo hepatitis B in recipients of core antibody-positive livers with lamivudine and other nucleos(t)ides: a 12-year experience.
Topics: Adenine; Adult; Aged; Analysis of Variance; Antiviral Agents; Biomarkers; Chi-Square Distribution; DNA, Viral; Donor Selection; Female; Guanine; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Logistic Models; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Factors; Tenofovir; Time Factors; Tissue Donors; Treatment Outcome; Viral Load | 2013 |
[Three-year efficacy and side effect of adefovir dipivoxil for the treatment of the old patients with chronic hepatitis B virus infection].
Topics: Adenine; Aged; Aged, 80 and over; Antiviral Agents; Female; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Time Factors | 2012 |
Tenofovir treatment of the severe acute hepatitis B.
Topics: Acute Disease; Adenine; Antiviral Agents; Hepatitis B; Humans; Male; Middle Aged; Organophosphonates; Severity of Illness Index; Tenofovir | 2013 |
Preformulation and development of a once-daily sustained-release tenofovir vaginal tablet tablet containing a single excipient.
Topics: Adenine; Anti-HIV Agents; Delayed-Action Preparations; Excipients; Female; Hardness; Humans; Organophosphonates; Particle Size; Polymers; Tenofovir; Vaginal Creams, Foams, and Jellies | 2013 |
Chronic hepatitis B treatment initiation and modification patterns in five European countries: a 2-year longitudinal, non-interventional study.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Antiviral Agents; Disease Management; DNA, Viral; Europe; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Tenofovir | 2014 |
Cardiometabolic risk factors among HIV patients on antiretroviral therapy.
Topics: Adenine; Adolescent; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Cyclopropanes; Female; HIV; HIV Infections; Humans; Insulin Resistance; Lamivudine; Male; Middle Aged; Nevirapine; Organophosphonates; Risk Factors; Stavudine; Tenofovir; Triglycerides; Zambia; Zidovudine | 2013 |
Reversible increase in FGF23 in a hypophosphatemic renal and bone disease linked to antiviral therapy by adefovir.
Topics: Adenine; Aged; Antiviral Agents; Bone Diseases; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Hepatitis B, Chronic; Humans; Hypophosphatemia; Kidney Diseases; Organophosphonates | 2013 |
B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model.
Topics: Adenine; Animals; Antigens, Bacterial; Aorta; Bacterial Toxins; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Organophosphonates; Phenylephrine; Rats; Rats, Sprague-Dawley; Second Messenger Systems; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2013 |
Snapshot on drug-resistance rate and profiles in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Recurrence; Telbivudine; Thymidine; Treatment Outcome | 2013 |
Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by low-dose adefovir dipivoxil: a case report and literature review suggesting ethnic predisposition.
Topics: Adenine; Antiviral Agents; Dose-Response Relationship, Drug; Fanconi Syndrome; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia | 2013 |
Access to treatment for HBV infection and its consistency with 2008 European guidelines in a multicentre cross-sectional study of HIV/HBV co-infected patients in Italy.
Topics: Adenine; Adult; Anti-Retroviral Agents; Coinfection; Cross-Sectional Studies; Deoxycytidine; Emtricitabine; Europe; Female; Guideline Adherence; Health Services Accessibility; Hepatitis B; HIV Infections; Humans; Infectious Disease Medicine; Italy; Lamivudine; Male; Multivariate Analysis; Organophosphonates; Practice Guidelines as Topic; Regression Analysis; Tenofovir; Treatment Outcome | 2013 |
Geographic tongue and tenofovir.
Topics: Adenine; Glossitis, Benign Migratory; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2013 |
[Genotypes and evolution characteristics of three patients with poor response to initial treatment of Lamivudine and Adefovir dipivoxil for hepatitis].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular; Female; Genetic Drift; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates | 2012 |
Oral nucleoside/nucleotide analogs without hepatitis B immune globulin after liver transplantation for hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kaplan-Meier Estimate; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Postoperative Care; Proportional Hazards Models; Secondary Prevention; Survival Rate; Viral Load; Young Adult | 2013 |
Drug synergy of tenofovir and nanoparticle-based antiretrovirals for HIV prophylaxis.
Topics: Adenine; Alkynes; Animals; Anti-HIV Agents; Benzoxazines; Cell Line; Cervix Uteri; Chemistry, Pharmaceutical; Cyclopropanes; Delayed-Action Preparations; Drug Carriers; Drug Synergism; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Inhibitory Concentration 50; Lactic Acid; Macaca; Models, Biological; Nanoparticles; Organophosphonates; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Saquinavir; Spectroscopy, Fourier Transform Infrared; Tenofovir; Tissue Culture Techniques | 2013 |
Prophylactic efficacy of oral emtricitabine and tenofovir disoproxil fumarate combination therapy against a tenofovir-resistant simian/human immunodeficiency virus containing the K65R mutation in macaques.
Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Deoxycytidine; Disease Transmission, Infectious; Drug Resistance, Viral; Emtricitabine; HIV; Macaca; Mutation, Missense; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome | 2013 |
Left ventricular hypertrophy detected by echocardiography in HIV-infected patients.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Carbamates; Comorbidity; Cross-Sectional Studies; Cyclopropanes; Diabetes Mellitus; Drug Combinations; Dyslipidemias; Echocardiography; Female; Furans; HIV Infections; Humans; Hypertension; Hypertrophy, Left Ventricular; Lamivudine; Lopinavir; Male; Middle Aged; Nevirapine; Organophosphates; Organophosphonates; Risk Factors; Ritonavir; Smoking; Spain; Sulfonamides; Tenofovir; Zidovudine | 2013 |
Drug-resistance development differs between HIV-1-infected patients failing first-line antiretroviral therapy containing nonnucleoside reverse transcriptase inhibitors with and without thymidine analogues.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Thymidine; Treatment Failure; Viral Load; Zidovudine | 2013 |
Influence of HIV infection on response to tenofovir in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Spain; Tenofovir; Treatment Outcome; Viral Load | 2013 |
Reversal of cirrhosis: an achievable goal of hepatitis B antiviral therapy.
Topics: Adenine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors | 2013 |
Could FDA approval of pre-exposure prophylaxis make a difference? A qualitative study of PrEP acceptability and FDA perceptions among men who have sex with men.
Topics: Adenine; Adult; Anti-Retroviral Agents; Chemoprevention; Deoxycytidine; Emtricitabine; Focus Groups; Health Knowledge, Attitudes, Practice; HIV Infections; Homosexuality, Male; Humans; Interviews as Topic; Male; Organophosphonates; Patient Acceptance of Health Care; Perception; Qualitative Research; Rhode Island; Sex Workers; Tenofovir; United States; United States Food and Drug Administration | 2014 |
Oral antiretroviral drugs as public health tools for HIV prevention: global implications for adherence, drug resistance, and the success of HIV treatment programs.
Topics: Adenine; Administration, Oral; Anti-HIV Agents; Counseling; Deoxycytidine; Drug Resistance, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Organophosphonates; Patient Compliance; Public Health; Tenofovir | 2013 |
Nucleoside reverse transcriptase inhibitor resistance mutations associated with first-line stavudine-containing antiretroviral therapy: programmatic implications for countries phasing out stavudine.
Topics: Adenine; Alkynes; Anti-Retroviral Agents; Benzoxazines; Cyclopropanes; Databases, Factual; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; HIV Infections; HIV-1; Humans; Mutation, Missense; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Viral; Stavudine; Tenofovir; Zidovudine | 2013 |
[Treatment of one advanced schistosomiasis patient with hepatitis B cirrhosis by lamivudine and adefovir dipivoxil].
Topics: Adenine; Adult; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Organophosphonates; Schistosomiasis | 2013 |
Partial virological response to adefovir add-on lamivudine rescue therapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Area Under Curve; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; ROC Curve; Treatment Outcome | 2013 |
Comparison of re-treatment outcomes of lamivudine plus adefovir or entecavir in chronic hepatitis B patients with viral relapse after cessation of adefovir.
Topics: Adenine; Adult; Antiviral Agents; Case-Control Studies; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Organophosphonates; Prospective Studies; Recurrence; Treatment Outcome | 2013 |
Comparison of tenofovir, zidovudine, or stavudine as part of first-line antiretroviral therapy in a resource-limited-setting: a cohort study.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; CD4 Lymphocyte Count; Cohort Studies; Female; Health Resources; HIV; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Residence Characteristics; RNA, Viral; Stavudine; Tenofovir; Young Adult; Zidovudine | 2013 |
Tenofovir disoproxil fumarate-associated nephrotoxicity in HIV-infected patients: a prospective controlled study.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Incidence; Kidney Diseases; Male; Organophosphonates; Prospective Studies; Tenofovir; Zidovudine | 2013 |
Short communication: Interferon/ribavirin treatment for HCV is associated with the development of hypophosphatemia in HIV/hepatitis C virus-coinfected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; Coinfection; Drug Interactions; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; HIV Infections; Humans; Hypophosphatemia; Interferons; Kidney Diseases; Male; Middle Aged; Organophosphonates; Retrospective Studies; Ribavirin; Risk Factors; Tenofovir | 2013 |
In vivo platelet activation and platelet hyperreactivity in abacavir-treated HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Blood Platelets; Case-Control Studies; CD40 Ligand; Cyclic GMP; Deoxyguanine Nucleotides; Dideoxynucleosides; Female; HIV Infections; Humans; Male; Middle Aged; Nitric Oxide; Organophosphonates; P-Selectin; Phospholipases A2, Secretory; Platelet Activation; Platelet Aggregation; Retrospective Studies; Tenofovir | 2013 |
Entecavir plus adefovir rescue therapy for chronic hepatitis B patients after multiple treatment failures in real-life practice.
Topics: Adenine; Adult; Antiviral Agents; Creatine Kinase; Creatinine; DNA, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Salvage Therapy; Treatment Outcome; Viral Load | 2013 |
Rates of switching antiretroviral drugs in a primary care service in South Africa before and after introduction of tenofovir.
Topics: Adenine; Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Drug Substitution; Drug-Related Side Effects and Adverse Reactions; Female; HIV; HIV Infections; Humans; Male; Organophosphonates; Primary Health Care; Retrospective Studies; Risk Factors; South Africa; Tenofovir | 2013 |
Vulnerability in research ethics: a way forward.
Topics: Adenine; Alzheimer Disease; Anti-HIV Agents; Cambodia; Community-Based Participatory Research; Ethics Committees, Research; Ethics, Research; HIV Infections; Human Experimentation; Humans; Informed Consent; Moral Obligations; Organophosphonates; Primary Prevention; Randomized Controlled Trials as Topic; Research Personnel; Research Subjects; Sex Workers; Tenofovir; Vulnerable Populations | 2013 |
Durability of first ART regimen and risk factors for modification, interruption or death in HIV-positive patients starting ART in Europe and North America 2002-2009.
Topics: Adenine; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cohort Studies; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Europe; HIV Infections; HIV Protease Inhibitors; HIV Seropositivity; HIV-1; Humans; Lamivudine; Lopinavir; Nevirapine; Organophosphonates; Reverse Transcriptase Inhibitors; Risk Factors; Tenofovir; Time Factors; United States | 2013 |
Once-daily darunavir/ritonavir and abacavir/lamivudine versus tenofovir/emtricitabine for treatment-naïve patients with a baseline viral load of more than 100 000 copies/ml.
Topics: Adenine; Anti-HIV Agents; Darunavir; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Organophosphonates; Ritonavir; Sulfonamides; Tenofovir; Viral Load | 2013 |
[Pharmacokinetics of tenofovir in Beagle dogs after oral dosing of tenofovir dipivoxil fumarate using HPLC-MS/MS analysis].
Topics: Adenine; Administration, Oral; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Dogs; Female; Male; Organophosphonates; Phosphorous Acids; Reverse Transcriptase Inhibitors; Tandem Mass Spectrometry; Tenofovir | 2013 |
Ethical considerations in determining standard of prevention packages for HIV prevention trials: examining PrEP.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Community-Based Participatory Research; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Ethics, Research; Health Services Needs and Demand; HIV Infections; Humans; Organophosphonates; Practice Guidelines as Topic; Primary Prevention; Research Design; Tenofovir; Treatment Failure; United States; United States Food and Drug Administration | 2013 |
Knowledge of and opinions on HIV preexposure prophylaxis among front-line service providers at Canadian AIDS service organizations.
Topics: Adenine; Adult; Anti-HIV Agents; Canada; Chemoprevention; Deoxycytidine; Emtricitabine; Female; Health Knowledge, Attitudes, Practice; Health Personnel; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Surveys and Questionnaires; Tenofovir | 2013 |
Peripheral T-cell apoptosis is not differentially affected by antiretroviral regimens in HIV-infected patients.
Topics: Adenine; Anti-HIV Agents; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cross-Sectional Studies; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; HIV Protease Inhibitors; Humans; Male; Middle Aged; Organophosphonates; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2013 |
Prophylaxis in HBV-infected liver transplant patients: end of the HBIG era?
Topics: Adenine; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Liver Transplantation; Male; Organophosphonates | 2013 |
The significance of antiretroviral-associated acute kidney injury in a cohort of ambulatory human immunodeficiency virus-infected patients.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Follow-Up Studies; Glomerular Filtration Rate; HIV; HIV Infections; Humans; Kidney Function Tests; Male; Organophosphonates; Prognosis; Prospective Studies; Risk Factors; Tenofovir | 2013 |
Tenofovir-emtricitabine therapy for the prevention of hepatitis B recurrence in four patients after liver transplantation.
Topics: Adenine; Adult; Antiviral Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B; Humans; Liver Transplantation; Male; Middle Aged; Organophosphonates; Secondary Prevention; Tenofovir | 2013 |
Resistance to tenofovir-based regimens during treatment failure of subtype C HIV-1 in South Africa.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; South Africa; Tenofovir; Treatment Failure; Viral Load | 2013 |
Pharmacokinetics of a multipurpose pod-intravaginal ring simultaneously delivering five drugs in an ovine model.
Topics: Adenine; Administration, Intravaginal; Animals; Anti-Retroviral Agents; Biopsy; Contraceptive Agents; Desogestrel; Drug Evaluation, Preclinical; Estradiol; Female; Intrauterine Devices, Medicated; Models, Animal; Nevirapine; Organophosphonates; Saquinavir; Sexually Transmitted Diseases, Viral; Sheep; Tenofovir; Time Factors | 2013 |
Mortality due to viral hepatitis in the Global Burden of Disease Study 2010: new evidence of an urgent global public health priority demanding action.
Topics: Adenine; Global Health; Healthy People Programs; Hepatitis, Viral, Human; Humans; Organophosphonates; Public Health; Reverse Transcriptase Inhibitors; Tenofovir | 2013 |
Update to Interim Guidance for Preexposure Prophylaxis (PrEP) for the Prevention of HIV Infection: PrEP for injecting drug users.
Topics: Adenine; Anti-HIV Agents; Centers for Disease Control and Prevention, U.S.; Deoxycytidine; Emtricitabine; Female; Heterosexuality; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Risk Assessment; Substance Abuse, Intravenous; Tenofovir; United States | 2013 |
Study design considerations for evaluating efficacy of systemic preexposure prophylaxis interventions.
Topics: Adenine; Anti-HIV Agents; Clinical Trials, Phase III as Topic; Delayed-Action Preparations; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; Humans; Medication Adherence; Organophosphonates; Randomized Controlled Trials as Topic; Research Design; Sample Size; Tenofovir; Treatment Outcome; United States | 2013 |
Ethics and pre-exposure prophylaxis for HIV infection.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Organophosphonates; Public Health; Risk-Taking; Tenofovir; United States | 2013 |
Topical microbicides--what's new?
Topics: Adenine; Anti-Infective Agents, Local; Anti-Retroviral Agents; Drug Delivery Systems; Female; Gels; HIV Infections; Humans; Male; Medication Adherence; Organophosphonates; Reproductive Health; Tenofovir; Treatment Outcome | 2013 |
HIV pre-exposure prophylaxis in injecting drug users.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Male; Organophosphonates; Substance Abuse, Intravenous; Tenofovir | 2013 |
High throughput LC-MS/MS method for simultaneous determination of tenofovir, lamivudine and nevirapine in human plasma.
Topics: Adenine; Chromatography, High Pressure Liquid; Humans; Lamivudine; Linear Models; Male; Nevirapine; Organophosphonates; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Tenofovir | 2013 |
Noncompetitive inhibition of hepatitis B virus reverse transcriptase protein priming and DNA synthesis by the nucleoside analog clevudine.
Topics: Adenine; Arabinofuranosyluracil; DNA, Viral; Guanine; HEK293 Cells; Hepatitis B virus; Humans; Organophosphonates; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Tenofovir; Viral Proteins | 2013 |
Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Hydrolysis; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Multidrug Resistance-Associated Proteins; Nelfinavir; Organophosphonates; Ritonavir | 2013 |
Role of traditional risk factors and antiretroviral drugs in the incidence of chronic kidney disease, ANRS CO3 Aquitaine cohort, France, 2004-2012.
Topics: Adenine; Age Factors; Anti-Retroviral Agents; Cohort Studies; Contraindications; Female; France; Glomerular Filtration Rate; HIV Infections; Humans; Incidence; Kaplan-Meier Estimate; Male; Organophosphonates; Poisson Distribution; Prospective Studies; Protease Inhibitors; Regression Analysis; Renal Insufficiency, Chronic; Risk Factors; Sex Factors; Tenofovir | 2013 |
Tenofovir helps prevent HIV in drug users.
Topics: Adenine; Anti-HIV Agents; Drug Users; HIV Infections; Humans; Organophosphonates; Substance-Related Disorders; Tenofovir | 2013 |
Complera for the treatment of HIV.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Emtricitabine, Rilpivirine, Tenofovir Drug Combination; HIV Infections; HIV-1; Humans; Nitriles; Nurse Practitioners; Organophosphonates; Practice Guidelines as Topic; Pyrimidines | 2013 |
Living related liver transplantation for hepatitis B-related liver disease without hepatitis B immune globulin prophylaxis.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Immunosuppression Therapy; Immunosuppressive Agents; Lamivudine; Liver Transplantation; Living Donors; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir; Treatment Outcome | 2013 |
Regression of cirrhosis with long-term tenofovir treatment.
Topics: Adenine; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors | 2013 |
Patterns of hepatitis B surface antigen decline and HBV DNA suppression in Asian treatment-experienced chronic hepatitis B patients after three years of tenofovir treatment.
Topics: Adenine; Adult; Aged; Antiviral Agents; Asian People; DNA, Viral; Female; Follow-Up Studies; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hong Kong; Humans; Kinetics; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Young Adult | 2013 |
Interactions between tenofovir and nevirapine in CD4+ T cells and monocyte-derived macrophages restrict their intracellular accumulation.
Topics: Adenine; Anti-HIV Agents; Blood Donors; CD4-Positive T-Lymphocytes; Cells, Cultured; Drug Interactions; Healthy Volunteers; Humans; Macrophages; Nevirapine; Organophosphonates; Tenofovir | 2013 |
Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.
Topics: Adenine; Adult; Cell Line; Codon, Nonsense; Drug Resistance, Viral; Female; Gene Expression; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatocytes; Humans; Male; Middle Aged; Mutation; Organophosphonates; Protein Binding; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Selection, Genetic; Treatment Failure | 2013 |
Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.
Topics: Adenine; Anti-HIV Agents; Cell Line; Deoxyadenosines; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutant Proteins; Mutation, Missense; Organophosphonates; Tenofovir | 2013 |
Neutrophil gelatinase-associated lipocalin, a marker of tubular dysfunction, is not increased in long-term virologically controlled patients receiving a tenofovir/emtricitabine + nevirapine regimen.
Topics: Acute-Phase Proteins; Adenine; Adult; Anti-HIV Agents; Cross-Sectional Studies; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Lipocalin-2; Lipocalins; Male; Middle Aged; Nevirapine; Organophosphonates; Proto-Oncogene Proteins; Tenofovir | 2013 |
[Pre-exposure prophylaxis for HIV transmission? No, unless].
Topics: Adenine; Anti-HIV Agents; Chemoprevention; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Organophosphonates; Tenofovir | 2013 |
Tenofovir-associated Fanconi syndrome in patients with chronic hepatitis B monoinfection.
Topics: Adenine; Adult; Antiviral Agents; Biopsy; Creatinine; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Kidney; Male; Middle Aged; Organophosphonates; Phosphates; Reverse Transcriptase Inhibitors; Tenofovir | 2013 |
Tenofovir-related Fanconi's syndrome and osteomalacia in a teenager with HIV.
Topics: Adenine; Adolescent; Anti-HIV Agents; Fanconi Syndrome; HIV Infections; Humans; Male; Organophosphonates; Osteomalacia; Tenofovir | 2013 |
[Crucial risk factors for renal function deterioration of HIV-infected patients at the AIDS Clinic in Rambam Hospital].
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Coinfection; Female; Glomerular Filtration Rate; Hepatitis C; HIV Infections; Humans; Israel; Male; Medical Records, Problem-Oriented; Middle Aged; Models, Statistical; Organophosphonates; Renal Insufficiency; Retrospective Studies; Risk Factors; Tenofovir | 2013 |
Effect of antiretroviral therapy on HIV reservoirs in elite controllers.
Topics: Adenine; Anti-HIV Agents; Asymptomatic Diseases; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Deoxycytidine; DNA, Viral; Drug Therapy, Combination; Emtricitabine; HIV Infections; HIV-1; Humans; Immunity, Innate; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Viremia; Virus Replication | 2013 |
Chemokine receptor 5 (CCR5) polymorphism in chronic hepatitis B patients treated with three different nucleos(t)ide analogues.
Topics: Adenine; Alanine Transaminase; Genotype; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Homozygote; Humans; India; Lamivudine; Liver Function Tests; Mutation; Nucleosides; Nucleotides; Organophosphonates; Pilot Projects; Polymorphism, Genetic; Receptors, CCR5; Telbivudine; Thymidine | 2013 |
Tenofovir-related nephrotoxicity: an ongoing clinical challenge.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Risk Factors; Tenofovir | 2013 |
Organic vapor sorption method of isostructural solvates and polymorph of tenofovir disoproxil fumarate.
Topics: 2-Propanol; Acetonitriles; Adenine; Adsorption; Anti-HIV Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallization; Cyclohexanes; Ethanol; Organophosphonates; Powder Diffraction; Solvents; Spectroscopy, Fourier Transform Infrared; Tenofovir; Thermogravimetry; Toluene; Volatilization; X-Ray Diffraction | 2013 |
Pre-exposure prophylaxis for conception (PrEP-C) as a risk reduction strategy in HIV-positive men and HIV-negative women in the UK.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Family Characteristics; Female; Fertility; HIV Seronegativity; HIV Seropositivity; Humans; Infectious Disease Transmission, Vertical; Male; Middle Aged; Organophosphonates; Preconception Care; Pregnancy; Pregnancy Outcome; Risk Reduction Behavior; Semen; Semen Analysis; Tenofovir; Viral Load | 2014 |
Nucleoside plus nucleotide analogs and cessation of hepatitis B immunoglobulin after liver transplantation in chronic hepatitis B is safe and effective.
Topics: Adenine; Adult; Aged; Antiviral Agents; Chemoprevention; Cohort Studies; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Hepatitis B Antibodies; Hepatitis B, Chronic; Humans; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2013 |
Regression of oral Kaposi's sarcoma after combination antiretroviral therapy.
Topics: Adenine; Adult; AIDS-Related Opportunistic Infections; Alkynes; Anti-Retroviral Agents; Benzoxazines; Cyclopropanes; Drug Therapy, Combination; Humans; Lamivudine; Male; Organophosphonates; Sarcoma, Kaposi; Tenofovir | 2013 |
Severe recurrent rhabdomyolysis-induced acute kidney injury in a HIV-infected patient on antiretroviral therapy.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; HIV Infections; Humans; Kidney Tubular Necrosis, Acute; Male; Organophosphonates; Rhabdomyolysis; Tenofovir | 2013 |
WHO survey finds half of countries do not have clinical guidelines for treating hepatitis.
Topics: Adenine; Antiviral Agents; Drugs, Essential; Global Health; Guanine; Health Priorities; Hepatitis B; Hepatitis C; Humans; Interferon alpha-2; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Practice Guidelines as Topic; Recombinant Proteins; Tenofovir; World Health Organization | 2013 |
HIV-HBV coinfection in Southern Africa and the effect of lamivudine- versus tenofovir-containing cART on HBV outcomes.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Coinfection; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B; Hepatitis B virus; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; South Africa; Tenofovir; Treatment Outcome; Zambia | 2013 |
Evaluation of the effect of cobicistat on the in vitro renal transport and cytotoxicity potential of tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Carbamates; Cell Line; Cobicistat; Drug Interactions; Humans; In Vitro Techniques; Kidney; Male; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Organophosphonates; Tenofovir; Thiazoles | 2013 |
Refractory AIDS cholangiopathy: metabolic complications and the role of plasmapheresis.
Topics: Abdominal Pain; Acquired Immunodeficiency Syndrome; Adenine; AIDS-Related Opportunistic Infections; CD4 Lymphocyte Count; Cholangitis; Deoxycytidine; Emtricitabine; Humans; Jaundice; Male; Organophosphonates; Plasmapheresis; Pyrrolidinones; Raltegravir Potassium; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2013 |
An evaluation of polycaprolactone matrices for vaginal delivery of the antiviral, tenofovir, in preventing heterosexual transmission of HIV.
Topics: Adenine; Administration, Intravaginal; Antiviral Agents; Drug Delivery Systems; HeLa Cells; Heterosexuality; HIV Infections; Humans; Organophosphonates; Polyesters; Porosity; Powders; Tenofovir | 2013 |
Study of hepatitis B virus quasispecies by ultra-deep pyrosequencing: Resolving the nitty-gritty.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates | 2014 |
Evolution of glomerular filtration rate in HIV-infected, HIV-HBV-coinfected and HBV-infected patients receiving tenofovir disoproxil fumarate.
Topics: Adenine; Adult; Antiviral Agents; Coinfection; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; HIV Infections; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Risk Factors; Tenofovir | 2013 |
Reply: To PMID 23505208.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates | 2014 |
Formulation and transport properties of tenofovir loaded liposomes through Caco-2 cell model.
Topics: Adenine; Caco-2 Cells; HIV Protease Inhibitors; Humans; Liposomes; Microscopy, Electron, Scanning; Models, Biological; Organophosphonates; Surface Properties; Tenofovir | 2013 |
Targeting of the purine biosynthesis host cell pathway enhances the activity of tenofovir against sensitive and drug-resistant HIV-1.
Topics: Adenine; Cells, Cultured; Drug Resistance, Viral; Drug Synergism; HIV-1; Host-Pathogen Interactions; Humans; Leukocytes, Mononuclear; Organophosphonates; Purines; Receptors, CCR5; Resveratrol; Reverse Transcriptase Inhibitors; Stilbenes; Tenofovir; Virus Replication | 2013 |
Tubular and glomerular proteinuria in HIV-infected adults with estimated glomerular filtration rate ≥ 60 ml/min per 1.73 m2.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Cross-Sectional Studies; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Glomerulus; Kidney Tubules; Male; Middle Aged; Organophosphonates; Proteinuria; Regression Analysis; Renal Insufficiency, Chronic; Risk Factors; Tenofovir | 2013 |
Long-term efficacy and emergence of multidrug resistance in patients with lamivudine-refractory chronic hepatitis B treated by combination therapy with adefovir plus lamivudine.
Topics: Adenine; Adult; Aged; Asian People; DNA, Viral; Drug Resistance, Multiple; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Treatment Outcome | 2014 |
Preexposure prophylaxis will have a limited impact on HIV-1 drug resistance in sub-Saharan Africa: a comparison of mathematical models.
Topics: Adenine; Adolescent; Adult; Africa South of the Sahara; Aged; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Models, Theoretical; Organophosphonates; Pre-Exposure Prophylaxis; Tenofovir; Young Adult | 2013 |
Antiretroviral preexposure prophylaxis for preventing HIV infection in high-risk individuals.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Female; HIV Infections; Humans; Male; Organophosphonates; Premedication | 2013 |
The impact of choice of NNRTI on short-term treatment outcomes among HIV-infected patients prescribed tenofovir and lamivudine in Johannesburg, South Africa.
Topics: Adenine; Adult; Anti-HIV Agents; Drug Therapy, Combination; Female; HIV Infections; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; South Africa; Tenofovir; Treatment Outcome; Viral Load | 2013 |
[Ophthalmological alterations at the initial diagnosis of HIV infection].
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Cyclohexanes; Deoxycytidine; Drug Therapy, Combination; Early Diagnosis; Emtricitabine; Eye Infections, Viral; HIV Infections; Humans; Lopinavir; Male; Maraviroc; Organophosphonates; Retinal Diseases; Syndrome; Tenofovir; Treatment Outcome; Triazoles; Zidovudine | 2014 |
Safety and efficacy of tenofovir/emtricitabine or abacavir/lamivudine in combination with efavirenz in treatment naïve HIV patients: a 5 year retrospective observational cohort study. (the TOKEN Study).
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cardiovascular Diseases; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; HIV Infections; Humans; Kidney Diseases; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Viral Load | 2013 |
Depletion of the cellular antioxidant system contributes to tenofovir disoproxil fumarate - induced mitochondrial damage and increased oxido-nitrosative stress in the kidney.
Topics: Adenine; Animals; Antioxidants; Glutathione; Glutathione Peroxidase; Kidney; Kidney Tubules, Proximal; Mitochondria; Mitochondrial Diseases; Organophosphonates; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Tenofovir | 2013 |
FDA must publish data on safety and efficacy of prophylactic AIDS drug, court rules.
Topics: Access to Information; Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Drug Therapy, Combination; Emtricitabine; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Humans; Organophosphonates; Organophosphorus Compounds; Publishing; Tenofovir; United States; United States Food and Drug Administration | 2013 |
[ First integrase inhibitor based single tablet regimen].
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Carbamates; Cobicistat; Deoxycytidine; Drug Approval; Drug Combinations; Emtricitabine; HIV Infections; HIV Integrase Inhibitors; Humans; Organophosphonates; Quinolones; Tenofovir; Thiazoles; Treatment Outcome | 2013 |
Non-occupational HIV post-exposure prophylaxis at a Sydney metropolitan sexual health clinic.
Topics: Adenine; Adult; Anti-HIV Agents; Australia; Deoxycytidine; Drug Administration Schedule; Drug Therapy, Combination; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Male; Middle Aged; Organophosphonates; Post-Exposure Prophylaxis; Practice Guidelines as Topic; Practice Patterns, Physicians'; Risk-Taking; Stavudine; Tenofovir | 2013 |
[The observation of blood serum creatinine and phosphorus during long-term adefovir dipivoxil treatment in chronic hepatitis].
Topics: Adenine; Adolescent; Adult; Aged; Creatinine; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Phosphorus; Retrospective Studies; Young Adult | 2013 |
Hypophosphataemia with non-tenofovir-containing antiretroviral therapy.
Topics: Adenine; Adult; Anti-Retroviral Agents; Cross-Sectional Studies; Female; Glomerular Filtration Rate; HIV Infections; Hospitals, Teaching; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Phosphates; Prevalence; Prospective Studies; Risk Factors; Tenofovir; Treatment Outcome; United Kingdom | 2013 |
[Detection of resistance mutations in chronic hepatitis B patients receiving antiviral therapy for over one year].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Polymerase Chain Reaction; Young Adult | 2013 |
[HBV vaccine escape mutations in a chronic hepatitis B patient treated with nucleos(t)ide analogues].
Topics: Adenine; Biopsy; Drug Resistance, Multiple, Viral; Female; Genes, pol; Guanine; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver; Middle Aged; Mutation; Nucleosides; Nucleotides; Organophosphonates; Tenofovir | 2013 |
Effect of tenofovir with and without interferon on hepatitis D virus replication in HIV-hepatitis B virus-hepatitis D virus-infected patients.
Topics: Adenine; Adult; Female; Hepatitis B virus; Hepatitis Delta Virus; HIV; HIV Infections; Humans; Interferons; Limit of Detection; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2013 |
Increased risk of dialysis and end-stage renal disease among HIV patients in Denmark compared with the background population.
Topics: Adenine; Adult; Anti-HIV Agents; Atazanavir Sulfate; Cohort Studies; Comorbidity; Denmark; Female; HIV Infections; Humans; Incidence; Kidney Failure, Chronic; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Renal Dialysis; Renal Replacement Therapy; Risk Factors; Tenofovir | 2014 |
Acute kidney injury caused by tenofovir disoproxil fumarate and diclofenac co-administration.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Interactions; Fanconi Syndrome; Female; Germany; HIV Infections; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir | 2013 |
Preexposure prophylaxis reduces HIV risk in injection-drug users.
Topics: Adenine; Adult; Anti-HIV Agents; Centers for Disease Control and Prevention, U.S.; Comorbidity; Deoxycytidine; Drug Administration Schedule; Drug Users; Emtricitabine; Female; Follow-Up Studies; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Male; Organophosphonates; Practice Guidelines as Topic; Pregnancy; Risk Reduction Behavior; Substance Abuse, Intravenous; Tenofovir; United States | 2013 |
Comparison of cardiovascular disease risk markers in HIV-infected patients receiving abacavir and tenofovir: the nucleoside inflammation, coagulation and endothelial function (NICE) study.
Topics: Adenine; Adult; Anti-HIV Agents; Biomarkers; Blood Coagulation; Cardiovascular Diseases; Dideoxynucleosides; Endothelium, Vascular; Female; HIV Infections; Humans; Inflammation; Male; Middle Aged; Organophosphonates; Risk Factors; Tenofovir; Zidovudine | 2014 |
Long-term efficacy of entecavir plus adefovir combination therapy versus entecavir monotherapy in adefovir refractory chronic hepatitis B patients with prior lamivudine resistance.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2014 |
Validation of a fast method for quantitative analysis of elvitegravir, raltegravir, maraviroc, etravirine, tenofovir, boceprevir and 10 other antiretroviral agents in human plasma samples with a new UPLC-MS/MS technology.
Topics: Adenine; Anti-Retroviral Agents; Chromatography, High Pressure Liquid; Cyclohexanes; Humans; Maraviroc; Mass Spectrometry; Nitriles; Organophosphonates; Proline; Pyridazines; Pyrimidines; Pyrrolidinones; Quinolones; Raltegravir Potassium; Tandem Mass Spectrometry; Tenofovir; Time Factors; Triazoles | 2013 |
In vivo antiviral activity of telbivudine against HIV-1: a case report.
Topics: Acute Disease; Adenine; Adult; Antiviral Agents; Coinfection; Drug Therapy, Combination; Hepatitis B; Hepatitis B virus; HIV Infections; HIV-1; Humans; Immunocompromised Host; Male; Organophosphonates; Telbivudine; Thymidine; Treatment Outcome | 2013 |
HIV antiretroviral prophylaxis for injecting drug users.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Male; Organophosphonates; Substance Abuse, Intravenous | 2013 |
HIV antiretroviral prophylaxis for injecting drug users.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Male; Organophosphonates; Substance Abuse, Intravenous | 2013 |
HIV antiretroviral prophylaxis for injecting drug users.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Male; Organophosphonates; Substance Abuse, Intravenous | 2013 |
HIV antiretroviral prophylaxis for injecting drug users.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Male; Organophosphonates; Substance Abuse, Intravenous | 2013 |
HIV antiretroviral prophylaxis for injecting drug users - Authors' reply.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Male; Organophosphonates; Substance Abuse, Intravenous | 2013 |
Predictors of survival in hepatitis B virus related decompensated cirrhosis on tenofovir therapy: an Indian perspective.
Topics: Adenine; Adult; Aged; Bilirubin; Creatinine; DNA, Viral; Female; Hepatitis B, Chronic; Humans; India; Liver Cirrhosis; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Platelet Count; Prospective Studies; Severity of Illness Index; Survival Analysis; Tenofovir; Treatment Outcome; Viral Load | 2013 |
No evidence for selection of HIV-1 with enhanced gag-protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial.
Topics: Adenine; Anti-HIV Agents; Clinical Trials as Topic; Female; gag Gene Products, Human Immunodeficiency Virus; HIV Infections; HIV-1; Humans; nef Gene Products, Human Immunodeficiency Virus; Organophosphonates; Phylogeny; Sequence Analysis, DNA; Tenofovir; Vaginal Creams, Foams, and Jellies; Virus Replication | 2013 |
Combination lamivudine and adefovir versus entecavir for the treatment of naïve chronic hepatitis B patients: a pilot study.
Topics: Adenine; Adult; Alanine Transaminase; Analysis of Variance; Aspartate Aminotransferases; Bilirubin; Drug Combinations; Enzyme-Linked Immunosorbent Assay; Female; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Organophosphonates; Pilot Projects | 2013 |
Evaluation of renal adverse effects of combination anti-retroviral therapy including tenofovir in HIV-infected patients.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Atazanavir Sulfate; CD4 Lymphocyte Count; Drug Combinations; Female; Glomerular Filtration Rate; HIV Infections; HIV Protease Inhibitors; Humans; Kidney; Kidney Diseases; Male; Middle Aged; Oligopeptides; Organophosphonates; Pyridines; Retrospective Studies; Reverse Transcriptase Inhibitors; Ritonavir; RNA, Viral; Tenofovir | 2013 |
[Changing spectrum of renal disease in HIV infection].
Topics: Adenine; Adult; AIDS-Associated Nephropathy; Amyloidosis; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biopsy; Cohort Studies; Cross-Sectional Studies; Diabetic Nephropathies; Female; Follow-Up Studies; Germany; Glomerulonephritis; Humans; Hypertension, Renal; Immune Complex Diseases; Kidney; Male; Middle Aged; Nephritis; Organophosphonates; Retrospective Studies; Serum Amyloid A Protein; Tenofovir | 2013 |
Changes in bone mineral density over a 2-year period in HIV-1-infected men under combined antiretroviral therapy with osteopenia.
Topics: Absorptiometry, Photon; Adenine; Adult; Anti-HIV Agents; Anti-Retroviral Agents; Bone Density; Bone Diseases, Metabolic; Hip; HIV Infections; HIV-1; Humans; Lumbar Vertebrae; Male; Middle Aged; Organophosphonates; Risk Factors; Tenofovir | 2013 |
Multicompartmental pharmacokinetic model of tenofovir delivery by a vaginal gel.
Topics: Adenine; Anti-HIV Agents; Area Under Curve; Epithelium; Female; HIV Infections; Humans; Models, Statistical; Mucous Membrane; Organophosphates; Organophosphonates; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies | 2013 |
Prophylactic tenofovir reduced HIV infection in injectable drug users.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Male; Organophosphonates; Substance Abuse, Intravenous | 2013 |
Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges.
Topics: Adenine; Administration, Intravaginal; Animals; Delayed-Action Preparations; Drug Delivery Systems; Female; HIV; Lentivirus Infections; Macaca mulatta; Organophosphonates; Simian Immunodeficiency Virus; Tenofovir | 2013 |
Acute kidney injury as a presentation of primary renal diffuse large B-cell lymphoma in HIV.
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Antinematodal Agents; Biopsy; HIV Infections; Humans; Kidney; Kidney Neoplasms; Lymphoma, Large B-Cell, Diffuse; Male; Organophosphonates; Tenofovir; Treatment Outcome | 2014 |
Real-world application of the roadmap model in chronic hepatitis B patients with telbivudine therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2013 |
The emergence of drug resistant HIV variants at virological failure of HAART combinations containing efavirenz, tenofovir and lamivudine or emtricitabine within the UK Collaborative HIV Cohort.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cohort Studies; Cyclopropanes; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure | 2014 |
Quantitation of tenofovir and emtricitabine in dried blood spots (DBS) with LC-MS/MS.
Topics: Adenine; Calibration; Chromatography, Liquid; Deoxycytidine; Dried Blood Spot Testing; Drug Stability; Emtricitabine; Hematocrit; Humans; Organophosphonates; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry; Temperature; Tenofovir | 2014 |
[Hypophosphatemia and chest pain related to adefovir dipivoxil treatment for chronic hepatitis B: report of two cases].
Topics: Adenine; Chest Pain; Female; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Young Adult | 2013 |
An investigation of the pattern of kidney injury in HIV-positive persons exposed to tenofovir disoproxil fumarate: an examination of a large population database (MHRA database).
Topics: Acute Kidney Injury; Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Databases, Factual; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Population Surveillance; Socioeconomic Factors; Tenofovir | 2014 |
Analysis and simulation of an Adefovir anti-hepatitis B virus infection therapy immune model with alanine aminotransferase.
Topics: Adenine; Alanine Transaminase; Algorithms; Antiviral Agents; Computer Simulation; DNA, Viral; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Immune System; Liver; Organophosphonates; T-Lymphocytes, Cytotoxic | 2013 |
Tenofovir-induced renal tubular dysfunction in vertically HIV-infected patients associated with polymorphisms in ABCC2, ABCC4 and ABCC10 genes.
Topics: Adenine; Anti-HIV Agents; Child; Female; HIV Infections; Humans; Kidney Diseases; Kidney Tubules; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Polymorphism, Single Nucleotide; Tenofovir; Young Adult | 2013 |
BMS-986001, an HIV nucleoside reverse transcriptase inhibitor, does not degrade mitochondrial DNA in long-term primary cultures of cells isolated from human kidney, muscle, and adipose tissue.
Topics: Adenine; Adipocytes; DNA Fragmentation; DNA, Mitochondrial; Epithelial Cells; Humans; Kidney Tubules, Proximal; Mitochondria; Muscle Fibers, Skeletal; Organophosphonates; Primary Cell Culture; Reverse Transcriptase Inhibitors; Stavudine; Structure-Activity Relationship; Tenofovir; Thymidine | 2013 |
Comparison of tenofovir and entecavir in patients with chronic HBV infection.
Topics: Adenine; Adult; Aged; DNA, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir | 2013 |
[Outcome of chronic hepatitis B and C in patients with inflammatory bowel disease treated with immunosuppressive drugs and anti-TNF agents].
Topics: Adalimumab; Adenine; Adult; Antibodies, Monoclonal, Humanized; Antiviral Agents; Azathioprine; Crohn Disease; Female; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Immunosuppressive Agents; Lamivudine; Male; Organophosphonates; Tumor Necrosis Factor-alpha; Viral Load; Viremia; Virus Activation | 2014 |
Efficacy of adefovir-based combination therapy for patients with Lamivudine- and entecavir-resistant chronic hepatitis B virus infection.
Topics: Adenine; Adult; Aged; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Treatment Outcome | 2013 |
Low prevalence of renal dysfunction in HIV-infected pregnant women: implications for guidelines for the prevention of mother-to-child transmission of HIV.
Topics: Adenine; Adult; Age Factors; Anti-HIV Agents; CD4 Lymphocyte Count; Contraindications; Creatinine; Female; HIV; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Kidney Diseases; Male; Mothers; Organophosphonates; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Pregnant Women; Prevalence; South Africa; Tenofovir; Viral Load | 2013 |
Potent inhibition of the C-P lyase nucleosidase PhnI by Immucillin-A triphosphate.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Catalysis; Escherichia coli; Escherichia coli Proteins; Lyases; Magnesium; Models, Chemical; Organophosphonates; Pentosephosphates; Polyphosphates; Pyrrolidines | 2013 |
Acceptability of pre-exposure prophylaxis among men who have sex with men and transgender women in Northern Thailand.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Anti-HIV Agents; Female; HIV Infections; Homosexuality, Male; Humans; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Outcome Assessment, Health Care; Patient Acceptance of Health Care; Self Report; Sexual Behavior; Sexual Partners; Tenofovir; Thailand; Transgender Persons; Young Adult | 2013 |
HBV clinical isolates expressing adefovir resistance mutations show similar tenofovir susceptibilities across genotypes B, C and D.
Topics: Adenine; Base Sequence; Cloning, Molecular; DNA Primers; Drug Resistance, Viral; Genotype; Hepatitis B; Hepatitis B virus; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation, Missense; Organophosphonates; Sequence Analysis, DNA; Tenofovir | 2014 |
A clinical prediction score for targeted creatinine testing before initiating tenofovir-based antiretroviral treatment in Cambodia.
Topics: Adenine; Adult; Anti-HIV Agents; Cambodia; Clinical Medicine; Creatinine; Cross-Sectional Studies; Decision Support Techniques; Female; HIV Infections; Humans; Kidney Diseases; Male; Metabolic Clearance Rate; Organophosphonates; Tenofovir | 2014 |
Lamivudine plus adefovir combination therapy for lamivudine resistance in hepatitis-B-related hepatocellular carcinoma patients.
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2013 |
[Efficacy and tolerability of antiretroviral therapy containing tenofovir disoproxil fumarate-emtricitabine-efavirenz in treatment-naive patients infected with HIV-1 in Bobo Dioulasso (Burkina Faso, 2009-2011)].
Topics: Adenine; Adult; Anti-Retroviral Agents; Burkina Faso; Deoxycytidine; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Oxazines; Retrospective Studies; Treatment Outcome | 2013 |
Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis.
Topics: Adenine; Adenylate Cyclase Toxin; Animals; Anti-Bacterial Agents; Bordetella pertussis; Caco-2 Cells; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; Macrophages; Mice; Microbial Sensitivity Tests; Organophosphonates; Prodrugs | 2014 |
Recurrent bone fractures due to tenofovir-induced renal phosphate wasting.
Topics: Adenine; Adult; Anti-HIV Agents; Fractures, Stress; HIV Infections; Humans; Kidney Diseases; Male; Organophosphonates; Phosphates; Radiography; Tenofovir; Whole Body Imaging | 2014 |
Delayed emergence of HIV-1 variants resistant to 4'-ethynyl-2-fluoro-2'-deoxyadenosine: comparative sequential passage study with lamivudine, tenofovir, emtricitabine and BMS-986001.
Topics: Adenine; Amino Acid Sequence; Anti-HIV Agents; Deoxyadenosines; Deoxycytidine; Drug Resistance, Multiple, Viral; Emtricitabine; HIV Infections; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Lamivudine; Molecular Sequence Data; Molecular Structure; Organophosphonates; Tenofovir; Thymidine | 2014 |
Urine liver-type fatty acid-binding protein and kidney injury molecule-1 in HIV-infected patients receiving combined antiretroviral treatment based on tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cross-Sectional Studies; Fatty Acid-Binding Proteins; Female; Hepatitis A Virus Cellular Receptor 1; HIV Infections; Humans; Kidney Diseases; Male; Membrane Glycoproteins; Middle Aged; Organophosphonates; Receptors, Virus; Tenofovir | 2014 |
Infant growth outcomes after maternal tenofovir disoproxil fumarate use during pregnancy.
Topics: Adenine; Adolescent; Anti-HIV Agents; Child Development; Female; Humans; Infant; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Tenofovir; Weight Gain | 2013 |
Prevelance of common YMDD motif mutations in long term treated chronic HBV infections in a Turkish population.
Topics: Adenine; Adult; Aged; Amino Acid Motifs; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Case-Control Studies; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Methionine; Middle Aged; Mutation; Organophosphonates; Prognosis; Retrospective Studies; Turkey; Tyrosine | 2013 |
Two rescue therapies in lamivudine-resistant patients with chronic hepatitis B in the central China: adefovir monotherapy and adefovir plus lamivudine.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; China; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Salvage Therapy; Treatment Outcome | 2014 |
Effect of tenofovir on nucleotidases and cytokines in HIV-1 target cells.
Topics: 5'-Nucleotidase; Adenine; CD4-Positive T-Lymphocytes; Cytokines; Dendritic Cells; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; HIV-1; Humans; Immunity, Innate; Immunologic Factors; Lymphocyte Activation; Macrophages; Organophosphonates; Tenofovir; Time Factors | 2013 |
One year of hepatitis B immunoglobulin plus tenofovir therapy is safe and effective in preventing recurrent hepatitis B post-liver transplantation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Immunoglobulins; Liver Transplantation; Male; Middle Aged; Organophosphonates; Secondary Prevention; Tenofovir; Treatment Outcome | 2014 |
WHO antiretroviral therapy guidelines 2010 and impact of tenofovir on chronic kidney disease in Vietnamese HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Organophosphonates; Renal Insufficiency, Chronic; Tenofovir; Vietnam | 2013 |
In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit.
Topics: Adenine; Animals; Anti-Retroviral Agents; Antibodies, Monoclonal; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Combined Modality Therapy; Drug Evaluation, Preclinical; Emtricitabine; Histocompatibility Antigens Class I; Immunity, Cellular; Immunoglobulin Fc Fragments; Immunotherapy; Lymphokines; Macaca mulatta; Organophosphonates; Programmed Cell Death 1 Receptor; Recombinant Proteins; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Solubility; Tenofovir; Viremia; Zalcitabine | 2013 |
Increases in regimen durability associated with the introduction of tenofovir at a large public-sector clinic in Johannesburg, South Africa.
Topics: Adenine; Adult; Ambulatory Care Facilities; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Female; HIV Infections; Humans; Male; Medication Adherence; Organophosphonates; South Africa; Tenofovir | 2013 |
Common clinical conditions - age, low BMI, ritonavir use, mild renal impairment - affect tenofovir pharmacokinetics in a large cohort of HIV-infected women.
Topics: Adenine; Adult; Age Factors; Anti-HIV Agents; Body Mass Index; Cohort Studies; Female; Glomerular Filtration Rate; HIV Infections; Humans; Middle Aged; Organophosphonates; Prospective Studies; Renal Insufficiency; Ritonavir; Tenofovir; Young Adult | 2014 |
Dead-end complexes contribute to the synergistic inhibition of HIV-1 RT by the combination of rilpivirine, emtricitabine, and tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Drug Synergism; Emtricitabine; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Nitriles; Organophosphonates; Pyrimidines; Reverse Transcription; Rilpivirine; Tenofovir; Virus Cultivation | 2014 |
Tenofovir or zidovudine in second-line antiretroviral therapy after stavudine failure in southern Africa.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Retreatment; South Africa; Stavudine; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load; Zidovudine | 2014 |
Cobicistat + elvitegravir + emtricitabine + tenofovir. Two new drugs, but no progress.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Carbamates; Cobicistat; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV-1; Humans; Organophosphonates; Quinolones; Tenofovir; Thiazoles | 2013 |
Rilpivirine, emtricitabine and tenofovir resistance in HIV-1-infected rilpivirine-naive patients failing antiretroviral therapy.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; HIV Infections; HIV-1; Humans; Nitriles; Organophosphonates; Pyrimidines; Rilpivirine; Sequence Analysis, DNA; Tenofovir; Treatment Failure | 2014 |
A liquid chromatography tandem mass spectrometry based regulatory compliant method for the determination of tenofovir in human serum.
Topics: Adenine; Chromatography, Liquid; Cold Temperature; Drug Stability; Humans; Organophosphonates; Reproducibility of Results; Tandem Mass Spectrometry; Tenofovir | 2014 |
Vaginally delivered tenofovir disoproxil fumarate provides greater protection than tenofovir against genital herpes in a murine model of efficacy and safety.
Topics: Adenine; Administration, Intravaginal; Animals; Antiviral Agents; Contraceptive Devices, Female; Disease Models, Animal; Drug Administration Schedule; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Mice; Mice, Inbred BALB C; Organophosphonates; Survival Analysis; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies | 2014 |
In vitro evaluation of 9-(2-phosphonylmethoxyethyl)adenine ester analogues, a series of anti-HBV structures with improved plasma stability and liver release.
Topics: Adenine; Animals; Antiviral Agents; Biotransformation; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Drug Liberation; Drug Stability; Esters; Hepatitis B virus; In Vitro Techniques; Liver; Molecular Structure; Organophosphonates; Rats; Spectrometry, Mass, Electrospray Ionization | 2014 |
Chronic hepatitis B monitoring and treatment patterns in five European countries with different access and reimbursement policies.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Europe; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Hospitalization; Humans; Insurance, Health, Reimbursement; Interferon-alpha; Lamivudine; Longitudinal Studies; Male; Middle Aged; Monitoring, Ambulatory; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; Tenofovir | 2014 |
Incorporated antivirals for chronic hepatitis B in Brazil: a cost-effectiveness analysis.
Topics: Adenine; Adult; Analysis of Variance; Antiviral Agents; Brazil; Cost-Benefit Analysis; Disease Progression; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Markov Chains; Organophosphonates; Tenofovir; Treatment Outcome | 2013 |
Telbivudine protects renal function in patients with chronic hepatitis B infection in conjunction with adefovir-based combination therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2014 |
CD4(+) cell count, viral load, and drug resistance patterns among heterosexual breakthrough HIV infections in a study of oral preexposure prophylaxis.
Topics: Adenine; Anti-HIV Agents; Botswana; CD4 Lymphocyte Count; Chemoprevention; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Heterosexuality; HIV; HIV Infections; Humans; Organophosphonates; Plasma; Post-Exposure Prophylaxis; Tenofovir; Viral Load | 2014 |
No evidence of sexual risk compensation in the iPrEx trial of daily oral HIV preexposure prophylaxis.
Topics: Adenine; Adolescent; Adult; Aged; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; Homosexuality, Male; Humans; Male; Middle Aged; Organophosphonates; Pregnancy; Sexual Behavior; Tenofovir; Transgender Persons; Young Adult | 2013 |
Impact of Tenofovir gel as a PrEP on HIV infection: a mathematical model.
Topics: Adenine; Female; Gels; HIV Infections; Humans; Models, Theoretical; Organophosphonates; Reverse Transcriptase Inhibitors; South Africa; Tenofovir | 2014 |
Comparative biophysical properties of tenofovir-loaded, thiolated and nonthiolated chitosan nanoparticles intended for HIV prevention.
Topics: Adenine; Animals; Anti-HIV Agents; Caveolins; Cell Line; Chitosan; Drug Delivery Systems; Fluorometry; HIV Infections; Humans; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanomedicine; Nanoparticles; Organophosphonates; Sulfhydryl Compounds; Swine; Tenofovir; Thioglycolates | 2014 |
Cost-effectiveness of tenofovir gel in urban South Africa: model projections of HIV impact and threshold product prices.
Topics: Adenine; Anti-HIV Agents; Circumcision, Male; Cost-Benefit Analysis; Female; Forecasting; Herpes Genitalis; Herpesvirus 2, Human; HIV Infections; HIV Seropositivity; Humans; Incidence; Male; Models, Economic; Organophosphonates; Prevalence; South Africa; Tenofovir | 2014 |
Efficacy and safety of tenofovir disoproxil fumarate in pregnancy for the prevention of vertical transmission of HBV infection.
Topics: Adenine; Antiviral Agents; Biomarkers; DNA, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Vaccines; Hepatitis B virus; Humans; Immunization Schedule; Immunoglobulins; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Retrospective Studies; Tenofovir; Time Factors; Treatment Outcome; Turkey; Viral Load | 2013 |
Interactions of tenofovir and tenofovir disoproxil fumarate with drug efflux transporters ABCB1, ABCG2, and ABCC2; role in transport across the placenta.
Topics: Adenine; Animals; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line; Female; Humans; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Organophosphonates; Rats; Rats, Wistar; Tenofovir | 2014 |
Telaprevir therapy, renal impairment, and their effects on the pharmacokinetics of tenofovir in HIV/hepatitis C virus coinfected patients.
Topics: Adenine; Adult; Antiviral Agents; Hepatitis C; HIV Infections; Humans; Kidney Diseases; Male; Oligopeptides; Organophosphonates; Tenofovir | 2014 |
Na⁺/H⁺ exchanger regulatory factor 3 is critical for multidrug resistance protein 4-mediated drug efflux in the kidney.
Topics: Adaptor Proteins, Signal Transducing; Adenine; Animals; Carrier Proteins; HEK293 Cells; Humans; Kidney; Membrane Proteins; Mice; Multidrug Resistance-Associated Proteins; Organophosphonates; Up-Regulation | 2014 |
Antiviral activity of genital tract secretions after oral or topical tenofovir pre-exposure prophylaxis for HIV-1.
Topics: Adenine; Administration, Intravaginal; Administration, Oral; Adult; Anti-HIV Agents; Bodily Secretions; Chemoprevention; Female; Genitalia, Female; Herpesvirus 2, Human; HIV-1; Humans; Mass Spectrometry; Microbial Sensitivity Tests; Organophosphonates; Tenofovir | 2014 |
Switch from tenofovir to raltegravir increases low bone mineral density and decreases markers of bone turnover over 48 weeks.
Topics: Absorptiometry, Photon; Adenine; Adult; Anti-HIV Agents; Biomarkers; Bone Density; Drug Substitution; Female; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Pelvic Bones; Pilot Projects; Pyrrolidinones; Raltegravir Potassium; Regression Analysis; Reverse Transcriptase Inhibitors; RNA, Viral; Spine; Tenofovir | 2014 |
Lamivudine compared with newer antivirals for prophylaxis of hepatitis B core antibody positive livers: a cost-effectiveness analysis.
Topics: Adenine; Antiviral Agents; Cohort Studies; Cost-Benefit Analysis; Decision Trees; Follow-Up Studies; Graft Survival; Guanine; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Lamivudine; Liver Transplantation; Markov Chains; Organophosphonates; Prognosis; Quality-Adjusted Life Years; Survival Rate; Tenofovir | 2014 |
Efficacy of 2years of entecavir plus adefovir therapy in patients with chronic hepatitis B who had failed on prior nucleos(t)ide analog treatment.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Retrospective Studies; Salvage Therapy; Treatment Outcome | 2014 |
Maximized mucoadhesion and skin permeation of anti-AIDS-loaded niosomal gels.
Topics: Adenine; Adhesiveness; Administration, Cutaneous; Administration, Intravaginal; Animals; Anti-HIV Agents; Cholesterol; Delayed-Action Preparations; Drug Compounding; Female; Hexoses; In Vitro Techniques; Mucous Membrane; Organophosphonates; Rabbits; Skin; Skin Absorption; Solubility; Surface Properties; Surface-Active Agents; Sus scrofa; Tenofovir; Transdermal Patch; Vagina; Vaginal Creams, Foams, and Jellies | 2014 |
Tenofovir is superior to entecavir for achieving complete viral suppression in HBeAg-positive chronic hepatitis B patients with high HBV DNA.
Topics: Adenine; Adult; Antiviral Agents; California; Cohort Studies; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome | 2014 |
Pharmacogenetics and clinical biomarkers for subtherapeutic plasma efavirenz concentration in HIV-1 infected Thai adults.
Topics: Adenine; Adolescent; Adult; Alkynes; Anti-HIV Agents; Asian People; Benzoxazines; Biomarkers; Cyclopropanes; Cytochrome P-450 Enzyme System; Female; Gene Frequency; HIV Infections; Humans; Lamivudine; Male; Organophosphonates; Polymorphism, Single Nucleotide; Prospective Studies; Tenofovir; Young Adult | 2014 |
Rapid detection of hepatitis B virus variants associated with lamivudine and adefovir resistance by multiplex ligation-dependent probe amplification combined with real-time PCR.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microbial Sensitivity Tests; Molecular Diagnostic Techniques; Multiplex Polymerase Chain Reaction; Mutation; Organophosphonates; Real-Time Polymerase Chain Reaction; Sensitivity and Specificity; Time | 2014 |
Factors associated with delayed hepatitis B viral suppression on tenofovir among patients coinfected with HBV-HIV in the CNICS cohort.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Time Factors; Treatment Outcome; Viral Load | 2014 |
Efficacy and safety of tenofovir-based rescue therapy for chronic hepatitis B patients with previous nucleo(s/t)ide treatment failure.
Topics: Adenine; Adult; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome | 2014 |
Efficacy of tenofovir in adefovir-experienced patients compared with treatment-naive patients with chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Tenofovir; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2014 |
Interactive medical case: wasting away.
Topics: Adenine; Adult; Bone Density; Electrolytes; Fanconi Syndrome; Female; Hepatitis B, Chronic; Humans; Hypokalemia; Nausea; Organophosphonates; Osteomalacia; Pain; Reverse Transcriptase Inhibitors; Tenofovir | 2014 |
Thermodynamic and kinetic investigation on the crucial factors affecting adefovir dipivoxil-saccharin cocrystallization.
Topics: Adenine; Antiviral Agents; Crystallization; Kinetics; Organophosphonates; Phase Transition; Powder Diffraction; Saccharin; Solubility; Thermodynamics; X-Ray Diffraction | 2014 |
Dynamic comparison between Daan real-time PCR and Cobas TaqMan for quantification of HBV DNA levels in patients with CHB.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Prospective Studies; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Sensitivity and Specificity; Viral Load; Young Adult | 2014 |
Experimental and molecular docking studies on DNA binding interaction of adefovir dipivoxil: advances toward treatment of hepatitis B virus infections.
Topics: Absorption; Adenine; Animals; Cattle; Circular Dichroism; DNA; Electrons; Hepatitis B; Hepatitis B virus; Kinetics; Ligands; Molecular Docking Simulation; Organophosphonates; Spectrometry, Fluorescence; Viscosity | 2014 |
Long-term observation of osteomalacia caused by adefovir-induced Fanconi's syndrome.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Humans; Male; Middle Aged; Organophosphonates; Osteomalacia | 2014 |
Pharmacokinetic and safety analyses of tenofovir and tenofovir-emtricitabine vaginal tablets in pigtailed macaques.
Topics: Adenine; Administration, Intravaginal; Animals; Deoxycytidine; Emtricitabine; Female; Macaca; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2014 |
Novel liquid chromatography-tandem mass spectrometry method for simultaneous detection of anti-HIV drugs Lopinavir, Ritonavir, and Tenofovir in plasma.
Topics: Adenine; Animals; Anti-HIV Agents; Chromatography, Liquid; Lopinavir; Macaca nemestrina; Organophosphonates; Ritonavir; Tandem Mass Spectrometry; Tenofovir | 2014 |
[Patient with HBsAg negativization during treatment. Could it be considered a cure for hepatitis B?].
Topics: Adenine; Adult; Antiviral Agents; Hepatitis B; Hepatitis B Surface Antigens; Humans; Male; Organophosphonates; Remission Induction | 2014 |
An initial assessment of correlations between host- and virus-related factors affecting analogues antiviral therapy in HBV chronically infected patients.
Topics: Adenine; Adult; Age Factors; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Host-Derived Cellular Factors; Humans; Interleukin-10; Lamivudine; Middle Aged; Mutation; Nucleosides; Organophosphonates; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Promoter Regions, Genetic; Sex Factors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tenofovir; Viral Load | 2014 |
[The clinical significance of hepatitis B virus large surface protein in the diagnosis and treatment of patients with hepatitis B].
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Female; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Young Adult | 2013 |
HIV nucleoside reverse transcriptase inhibitors efavirenz and tenofovir change the growth and differentiation of primary gingival epithelium.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cyclopropanes; Dose-Response Relationship, Drug; Gene Expression Regulation; Gingiva; HIV Infections; Humans; Keratin-6; Keratinocytes; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2014 |
Generation of a human hepatoma cell line supporting efficient replication of a lamivudine resistant hepatitis B virus.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hep G2 Cells; Hepatitis B virus; Hepatocytes; Humans; Lamivudine; Organophosphonates; Tenofovir; Virus Replication | 2014 |
Long-term treatment with tenofovir: prevalence of kidney tubular dysfunction and its association with tenofovir plasma concentration.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Comorbidity; Cross-Sectional Studies; Drug Monitoring; Female; HIV Infections; Humans; Kidney Diseases; Kidney Function Tests; Kidney Tubules; Male; Middle Aged; Netherlands; Organophosphonates; Prevalence; Tenofovir | 2014 |
Effect of baseline renal function on tenofovir-containing antiretroviral therapy outcomes in Zambia.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Creatinine; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Male; Organophosphonates; Renal Insufficiency; Tenofovir; Zambia | 2014 |
Editorial commentary: Risks and benefits of tenofovir in the context of kidney dysfunction in sub-Saharan Africa.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Male; Organophosphonates; Renal Insufficiency | 2014 |
Complete regression of early-stage gastric diffuse large B-cell lymphoma in an HIV-1-infected patient following Helicobacter pylori eradication therapy.
Topics: Adenine; Amoxicillin; Anti-Bacterial Agents; Antiretroviral Therapy, Highly Active; Clarithromycin; Female; Helicobacter Infections; Helicobacter pylori; HIV-1; Humans; Lansoprazole; Lymphoma, AIDS-Related; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Tenofovir | 2014 |
Incomplete reversibility of estimated glomerular filtration rate decline following tenofovir disoproxil fumarate exposure.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Drug Administration Schedule; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Tenofovir; Viral Load | 2014 |
Establishment of real time allele specific locked nucleic acid quantitative PCR for detection of HBV YIDD (ATT) mutation and evaluation of its application.
Topics: Adenine; Adult; Alleles; Antiviral Agents; DNA Primers; DNA, Viral; Drug Resistance, Viral; Early Diagnosis; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Isoleucine; Lamivudine; Limit of Detection; Male; Middle Aged; Molecular Sequence Data; Mutation; Nucleotide Motifs; Oligonucleotides; Organophosphonates; Real-Time Polymerase Chain Reaction | 2014 |
Impact of choice of NRTI in first-line antiretroviral therapy: a cohort analysis of stavudine vs. tenofovir.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Female; Follow-Up Studies; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Prospective Studies; South Africa; Stavudine; Survival Analysis; Survival Rate; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2014 |
Lamivudine and Adefovir Motif Variants Detected in chronic Hepatıtıs B patients.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Protein Domains | 2014 |
Acyclic nucleoside phosphonates: a study on cytochrome P450 gene expression.
Topics: Adenine; Animals; Blotting, Western; Cytochrome P-450 Enzyme System; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Organophosphonates; Real-Time Polymerase Chain Reaction; Tenofovir | 2014 |
Early experiences implementing pre-exposure prophylaxis (PrEP) for HIV prevention in San Francisco.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Disease Management; Emtricitabine; Female; HIV Infections; Humans; Male; Organophosphonates; San Francisco; Tenofovir | 2014 |
Incidence and risk factors for incomplete HBV DNA suppression in HIV/HBV-co-infected patients initiating tenofovir-based therapy.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cohort Studies; Coinfection; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Incidence; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Factors; Tenofovir; Viral Load; Viremia | 2014 |
Clinical problem-solving. Wasting away.
Topics: Adenine; Adult; Bone Diseases, Metabolic; Cachexia; Diagnosis, Differential; Fanconi Syndrome; Female; Hepatitis B; Humans; Hypophosphatemia; Liver Function Tests; Organophosphonates; Pelvic Bones; Phosphates; Radiography; Reverse Transcriptase Inhibitors; Tenofovir | 2014 |
Focal bone lesions in HIV-positive patient treated with tenofovir.
Topics: Adenine; Anti-HIV Agents; Bone Diseases; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Tenofovir | 2014 |
Use of hepatitis B surface and "e" antigen quantification during extensive treatment with tenofovir in patients co-infected with HIV-HBV.
Topics: Adenine; Adult; Anti-HIV Agents; Coinfection; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; Humans; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Prospective Studies; Sensitivity and Specificity; Tenofovir; Viral Load | 2015 |
[Detection and analysis of HBV in polymorphonuclear neutrophils of patients with hepatitis B].
Topics: Adenine; Adult; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Neutrophils; Organophosphonates | 2014 |
Mitochondrial dysfunction and electron transport chain complex defect in a rat model of tenofovir disoproxil fumarate nephrotoxicity.
Topics: Adenine; Animals; Anti-HIV Agents; Electron Transport Chain Complex Proteins; Fanconi Syndrome; Kidney Tubules, Proximal; Male; Mitochondria; Mitochondrial Swelling; Organophosphonates; Proteinuria; Rats, Wistar; Tenofovir | 2014 |
Fanconi syndrome caused by low-dose adefovir dipivoxil.
Topics: Adenine; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Humans; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors | 2014 |
Successful withdrawal of antiviral treatment in kidney transplant recipients with chronic hepatitis B viral infection.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Kidney Transplantation; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Time Factors; Virus Activation; Withholding Treatment | 2014 |
[Diagnosis and treatment of chronic hepatitis B and D. Hungarian national consensus guideline].
Topics: Adenine; Antiviral Agents; Consensus; Drug Administration Schedule; Drug Therapy, Combination; Evidence-Based Medicine; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D, Chronic; Hepatitis Delta Virus; Humans; Hungary; Interferon-alpha; Lamivudine; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Tenofovir | 2014 |
Corrective osteotomy in femoral non-union in drug-induced hypophosphataemic osteomalacia.
Topics: Adenine; Antiviral Agents; Femoral Neck Fractures; Fracture Fixation, Intramedullary; Fractures, Ununited; Humans; Male; Middle Aged; Organophosphonates; Osteotomy; Rickets, Hypophosphatemic | 2014 |
Disclosure of microbicide gel use to sexual partners: influence on adherence in the CAPRISA 004 trial.
Topics: Adenine; Adolescent; Adult; Anti-Infective Agents; Condoms; Disclosure; Female; Gels; HIV Infections; Humans; Interviews as Topic; Medication Adherence; Organophosphonates; Sexual Behavior; Sexual Partners; Socioeconomic Factors; South Africa; Surveys and Questionnaires; Tenofovir; Young Adult | 2014 |
Daily oral emtricitabine/tenofovir preexposure prophylaxis and herpes simplex virus type 2 among men who have sex with men.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Chemoprevention; Deoxycytidine; Emtricitabine; Herpes Simplex; Herpesvirus 2, Human; Homosexuality, Male; Humans; Incidence; Male; Middle Aged; Organophosphonates; Prevalence; Risk Factors; Tenofovir; Young Adult | 2014 |
The rate of recovery in renal function when patients with HIV infection discontinue treatment with tenofovir.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Male; Organophosphonates; Prospective Studies; Tenofovir; Withholding Treatment | 2014 |
HIV-1 genital shedding is suppressed in the setting of high genital antiretroviral drug concentrations throughout the menstrual cycle.
Topics: Adenine; Adult; Anti-Retroviral Agents; Deoxycytidine; DNA, Viral; Emtricitabine; Female; Genitalia, Female; HIV Infections; HIV-1; Humans; Menstrual Cycle; Middle Aged; Organophosphonates; Plasma; Ritonavir; RNA, Viral; Tenofovir; Viral Load; Virus Shedding | 2014 |
Leveraging rapid implementation of an HIV treatment policy to reduce confounding in observational analysis of antiretroviral outcomes.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Female; HIV Infections; Humans; Male; Organophosphonates; Stavudine; Tenofovir | 2014 |
Assessing adherence in the CAPRISA 004 tenofovir gel HIV prevention trial: results of a nested case-control study.
Topics: Adenine; Adult; Anti-HIV Agents; Anti-Infective Agents; Case-Control Studies; Condoms; Double-Blind Method; Female; HIV Infections; Humans; Logistic Models; Organophosphonates; Patient Compliance; Rural Population; South Africa; Tenofovir; Treatment Outcome; Urban Population; Vaginal Creams, Foams, and Jellies | 2014 |
The synthesis of tenofovir and its analogues via asymmetric transfer hydrogenation.
Topics: Adenine; Antiviral Agents; Catalysis; Combinatorial Chemistry Techniques; Hydrogenation; Molecular Structure; Organophosphonates; Tenofovir | 2014 |
Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients.
Topics: Adenine; Adult; Anti-HIV Agents; Case-Control Studies; Creatinine; Fanconi Syndrome; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Diseases; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Prognosis; Prospective Studies; Risk Factors; Tenofovir | 2014 |
[A case of the patient with HBeAg-negative chronic hepatitis B recurrence after retreatment with adefovir occurred HBsAg seroconversion].
Topics: Adenine; Adult; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Recurrence; Treatment Outcome | 2013 |
Anti-viral therapy for prevention of perinatal HBV transmission: extending therapy beyond birth does not protect against post-partum flare.
Topics: Adenine; Adult; Antiviral Agents; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infectious Disease Transmission, Vertical; Lamivudine; Male; Organophosphonates; Postpartum Period; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Severity of Illness Index; Tenofovir; Time Factors; Young Adult | 2014 |
Molecular basis of the association of H208Y and thymidine analogue resistance mutations M41L, L210W and T215Y in the HIV-1 reverse transcriptase of treated patients.
Topics: Adenine; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Microbial Sensitivity Tests; Mutation, Missense; Organophosphonates; Reverse Transcription; Tenofovir; Zidovudine | 2014 |
Reversible bone lesions induced by tenofovir disoproxil fumarate.
Topics: Adenine; Adult; Bone Diseases; Female; Humans; Organophosphonates; Radionuclide Imaging; Tenofovir | 2014 |
Single-tablet, once-daily treatment regimens for HIV.
Topics: Adenine; Alkynes; Anti-HIV Agents; Benzoxazines; Carbamates; Cobicistat; Cyclopropanes; Cytochrome P-450 CYP3A Inhibitors; Deoxycytidine; Drug Combinations; Emtricitabine; HIV Infections; HIV Integrase Inhibitors; HIV Reverse Transcriptase; Humans; Nitriles; Organophosphonates; Pyrimidines; Quinolones; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; Thiazoles | 2014 |
Formulation and characterization of drug loaded nonionic surfactant vesicles (niosomes) for oral bioavailability enhancement.
Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Biological Availability; Chemistry, Pharmaceutical; Kinetics; Liposomes; Male; Organophosphonates; Particle Size; Rats; Tenofovir | 2014 |
Higher risk of renal impairment associated with tenofovir use amongst people living with HIV in India: a comparative cohort analysis between Western India and United Kingdom.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Female; HIV Infections; Humans; India; Kidney Diseases; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; United Kingdom | 2014 |
Retention in care, resource utilization, and costs for adults receiving antiretroviral therapy in Zambia: a retrospective cohort study.
Topics: Adenine; Adult; Ambulatory Care Facilities; Anti-HIV Agents; CD4 Lymphocyte Count; Delivery of Health Care; Female; Guideline Adherence; Health Care Costs; Health Resources; HIV Infections; Humans; Male; Office Visits; Organophosphonates; Patient Dropouts; Retrospective Studies; Tenofovir; Zambia | 2014 |
PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.
Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; HIV; HIV Infections; Humans; Microbial Sensitivity Tests; Molecular Structure; Organophosphonates; Papillomavirus Infections; Prodrugs; Structure-Activity Relationship; Tenofovir; Tumor Cells, Cultured | 2014 |
Commentary: tenofovir is superior to entecavir in HBeAg-positive chronic hepatitis B patients.
Topics: Adenine; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Tenofovir | 2014 |
Commentary: tenofovir is superior to entecavir in HBeAg-positive chronic hepatitis B patients--authors' reply.
Topics: Adenine; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Tenofovir | 2014 |
Increased Dapivirine tissue accumulation through vaginal film codelivery of dapivirine and Tenofovir.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Anti-Infective Agents; Drug Delivery Systems; Female; HIV Infections; Humans; In Vitro Techniques; Membranes, Artificial; Organophosphonates; Pyrimidines; Tenofovir; Vagina | 2014 |
Virologic and serologic outcomes of mono versus dual HBV therapy and characterization of HIV/HBV coinfection in a US cohort.
Topics: Adenine; Adult; Antibodies, Viral; Antiretroviral Therapy, Highly Active; Antiviral Agents; CD4 Lymphocyte Count; Coinfection; Deoxycytidine; DNA, Viral; Emtricitabine; Female; Follow-Up Studies; Hepatitis B; Hepatitis B e Antigens; HIV Infections; Humans; Lamivudine; Logistic Models; Male; Middle Aged; Organophosphonates; Randomized Controlled Trials as Topic; Retrospective Studies; Tenofovir; United States | 2014 |
Fibroblast growth factor 23 is elevated in tenofovir-related hypophosphatemia.
Topics: Adenine; Adult; Anti-HIV Agents; Bone Density; Fanconi Syndrome; Fibroblast Growth Factor-23; Fibroblast Growth Factors; HIV Infections; Humans; Hypophosphatemia; Male; Organophosphonates; Osteomalacia; Osteoporosis; Tenofovir | 2014 |
Screening and identification of a novel adefovir dipivoxil resistance associated mutation, rtN236V, of HBV from a large cohort of HBV-infected patients.
Topics: Adenine; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Codon; DNA, Viral; Drug Resistance, Viral; Female; Genes, Viral; Genotype; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Time Factors; Viral Load; Virus Replication | 2014 |
Uptake of prevention of mother-to-child-transmission using Option B+ in northern rural Malawi: a retrospective cohort study.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Chemoprevention; Cohort Studies; Cyclopropanes; Female; HIV Infections; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Malawi; Nevirapine; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Prenatal Care; Retrospective Studies; Rural Population; Tenofovir; Young Adult | 2014 |
The preventive misconception: experiences from CAPRISA 004.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Anti-Infective Agents, Local; Female; Gels; HIV Infections; Humans; Informed Consent; Medication Adherence; Motivation; Organophosphonates; Personal Satisfaction; South Africa; Tenofovir; Young Adult | 2014 |
A cost-utility analysis of drug treatments in patients with HBeAg-positive chronic hepatitis B in Thailand.
Topics: Adenine; Adult; Antiviral Agents; Cost-Benefit Analysis; Drugs, Essential; Female; Health Services Research; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Markov Chains; Models, Economic; Organophosphonates; Quality-Adjusted Life Years; Tenofovir; Thailand; Treatment Outcome | 2014 |
Successful switch to rilpivirine/tenofovir/emtricitabine in HIV-1-infected patients with an isolated K103N mutation acquired during prior nonnucleoside reverse transcriptase inhibitor therapy.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Drug Substitution; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Mutation; Nitriles; Organophosphonates; Pilot Projects; Prospective Studies; Pyrimidines; Reverse Transcriptase Inhibitors; Rilpivirine; Tenofovir; Viral Load; Young Adult | 2014 |
HIV-1 drug resistance in the iPrEx preexposure prophylaxis trial.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Female; Genotype; HIV Infections; HIV-1; Homosexuality, Male; Humans; Male; Mutation; Organophosphonates; RNA, Viral; Tenofovir; Transgender Persons; Viral Load | 2014 |
Mapping antiretroviral drugs in tissue by IR-MALDESI MSI coupled to the Q Exactive and comparison with LC-MS/MS SRM assay.
Topics: Adenine; Anti-Retroviral Agents; Cervix Uteri; Chromatography, Liquid; Deoxycytidine; Emtricitabine; Female; Histocytochemistry; Humans; Molecular Imaging; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Tenofovir; Tissue Distribution | 2014 |
Does tenofovir gel or do other microbicide products affect detection of biomarkers of semen exposure in vitro?
Topics: Adenine; Anilides; Antibiotic Prophylaxis; Biomarkers; Cellulose; Chromosomes, Human, Y; DNA; Excipients; False Positive Reactions; Female; Furans; Humans; Limit of Detection; Organophosphonates; Osmolar Concentration; Prostate-Specific Antigen; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Semen; Tenofovir; Thioamides; Vaginal Creams, Foams, and Jellies | 2014 |
Relevance of hepatitis B surface antigen levels in patients with chronic hepatitis B during 5 year of tenofovir treatment.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Monitoring; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Time Factors; Young Adult | 2014 |
The root hair assay facilitates the use of genetic and pharmacological tools in order to dissect multiple signalling pathways that lead to programmed cell death.
Topics: Adenine; Androstadienes; Apoptosis; Arabidopsis; Arabidopsis Proteins; Autophagy; Biological Assay; Fumonisins; Gibberellins; Hot Temperature; Hydrogen Peroxide; Indans; Mitochondrial Swelling; Models, Biological; Mutation; Mycotoxins; Organophosphonates; Phenylalanine Ammonia-Lyase; Plant Roots; Salicylic Acid; Signal Transduction; Sodium Chloride; Stress, Physiological; Wortmannin | 2014 |
Hepatitis B virus rtI233V mutation and resistance to adefovir.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; RNA-Directed DNA Polymerase | 2014 |
Direct and real-time quantification of tenofovir release from ph-sensitive microparticles into simulated biological fluids using (1)h nuclear magnetic resonance.
Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Delayed-Action Preparations; Female; Humans; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Organophosphonates; Semen; Tenofovir; Vagina | 2014 |
Effects of entecavir on peripheral blood lymphocyte profiles in chronic hepatitis B patients with suboptimal responses to adefovir.
Topics: Adenine; Antiviral Agents; B-Lymphocytes; Case-Control Studies; CD4-Positive T-Lymphocytes; DNA, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Tumor Necrosis Factor Receptor Superfamily, Member 7; Viral Load | 2014 |
Sustained virological response after taking crushed elvitegravir-cobicistat-emtricitabine-tenofovir tablets.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; Carbamates; Cobicistat; Deoxycytidine; Emtricitabine; Female; HIV; HIV Infections; Humans; Organophosphonates; Powders; Quinolones; Tablets; Tenofovir; Thiazoles; Viral Load | 2014 |
ACOG Committee Opinion no 595: Committee on Gynecologic Practice: Preexposure prophylaxis for the prevention of human immunodeficiency virus.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Emtricitabine; Female; Gynecology; HIV Infections; Humans; Medication Adherence; Organophosphonates; Risk Factors; Tenofovir | 2014 |
ABCC2*1C and plasma tenofovir concentration are correlated to decreased glomerular filtration rate in patients receiving a tenofovir-containing antiretroviral regimen.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Creatinine; Cyclopropanes; Drug Therapy, Combination; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Kidney; Lamivudine; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Polymorphism, Single Nucleotide; Reverse Transcriptase Inhibitors; Tenofovir | 2014 |
Analysis of reverse transcriptase gene mutations in the hepatitis B virus at a university hospital in Korea.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hospitals, University; Humans; Lamivudine; Mutation; Organophosphonates; Phenotype; Republic of Korea; Retrospective Studies; RNA-Directed DNA Polymerase | 2014 |
Efficacy and safety of tenofovir disoproxil fumarate in pregnancy to prevent perinatal transmission of hepatitis B virus.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; Female; Gastrointestinal Diseases; Hepatitis B; Hepatitis B virus; Humans; Incidence; Lamivudine; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Prospective Studies; Tenofovir; Time Factors; Treatment Outcome; Viral Load | 2014 |
Letter: Treatment of HBeAg+ chronic hepatitis B--is tenofovir truly superior to entecavir?
Topics: Adenine; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Tenofovir | 2014 |
Letter: Treatment of HBeAg+ chronic hepatitis B--is tenofovir truly superior to entecavir? Authors' reply.
Topics: Adenine; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Tenofovir | 2014 |
HBsAg loss in patients treated with peginterferon alfa-2a and adefovir is associated with SLC16A9 gene variation and lower plasma carnitine levels.
Topics: Adenine; Adult; Antiviral Agents; Carnitine; CD8-Positive T-Lymphocytes; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Monocarboxylic Acid Transporters; Organophosphonates; Polyethylene Glycols; Polymorphism, Single Nucleotide; Prognosis; Recombinant Proteins; Treatment Outcome; Vitamin B Complex | 2014 |
Viral evolutionary changes during tenofovir treatment in a chronic hepatitis B patient with sequential nucleos(t)ide therapy.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Drug Substitution; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2014 |
An interesting case of 'diabetic foot ulcer' in an HIV-positive patient.
Topics: Adenine; Aged; Antiretroviral Therapy, Highly Active; Biopsy; Deoxycytidine; Diabetes Mellitus, Type 2; Diabetic Foot; Emtricitabine; Herpesvirus 8, Human; HIV Infections; HIV Seropositivity; Humans; Male; Organophosphonates; Sarcoma, Kaposi; Skin Neoplasms; Tenofovir; Treatment Outcome; Ulcer | 2015 |
Perceptions of emtricitabine-tenofovir in HIV PrEP.
Topics: Adenine; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; HIV Infections; Humans; Organophosphonates; Sex Education; Sexual Partners; Tenofovir; United States | 2014 |
Evaluation of HBV DNA decay kinetics in patients containing both rtM204V/I mutant and wild-type HBV subpopulations during tenofovir DF (TDF) monotherapy or combination therapy with emtricitabine (FTC)/TDF.
Topics: Adenine; Antiviral Agents; Deoxycytidine; DNA, Viral; Drug Therapy, Combination; Emtricitabine; Genetic Association Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kinetics; Mutation, Missense; Organophosphonates; Randomized Controlled Trials as Topic; Tenofovir; Treatment Outcome; Viral Load | 2014 |
Biomarkers of CD4+ T-cell activation as risk factors for tuberculosis-associated immune reconstitution inflammatory syndrome.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Biomarkers; CD4-Positive T-Lymphocytes; Cyclopropanes; Deoxycytidine; Emtricitabine; Enzyme-Linked Immunosorbent Assay; Female; HIV Infections; Humans; Immune Reconstitution Inflammatory Syndrome; Lymphocyte Activation; Male; Middle Aged; Mycobacterium tuberculosis; Organophosphonates; Risk Factors; Tenofovir; Tuberculosis | 2014 |
Effects of the W153L substitution in HIV reverse transcriptase on viral replication and drug resistance to multiple categories of reverse transcriptase inhibitors.
Topics: Adenine; Alkynes; Amino Acid Substitution; Anti-HIV Agents; Benzoxazines; Cyclopropanes; Drug Resistance, Viral; HEK293 Cells; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Mutagenesis, Site-Directed; Mutation; Nevirapine; Organophosphonates; Pyrimidines; Recombinant Proteins; Reverse Transcriptase Inhibitors; Tenofovir; Virus Replication | 2014 |
SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.
Topics: Adenine; Cell Line; Dideoxynucleotides; Gene Expression; Genes, Reporter; HIV Reverse Transcriptase; HIV-1; Host-Pathogen Interactions; Humans; Lamivudine; Luciferases; Monocytes; Monomeric GTP-Binding Proteins; Organophosphonates; Reverse Transcriptase Inhibitors; RNA, Small Interfering; SAM Domain and HD Domain-Containing Protein 1; Stavudine; Tenofovir; Virus Replication; Zidovudine | 2014 |
In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients.
Topics: Adenine; Adult; Alkynes; Animals; Anti-HIV Agents; Benzoxazines; Cyclopropanes; HIV Infections; Humans; Interleukin-10; Interleukin-6; Interleukin-8; Lamivudine; Male; Middle Aged; Organophosphonates; Platelet Activating Factor; Tenofovir; Tumor Necrosis Factor-alpha | 2014 |
Coexistence of HBsAg and HBsAb in a difficult-to-treat chronic hepatitis B: loss of HBsAg with entecavir plus tenofovir combination.
Topics: Adenine; Antiviral Agents; Drug Therapy, Combination; Guanine; Hepatitis B Antibodies; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Organophosphonates; Recombinant Proteins; Tenofovir; Treatment Failure; Treatment Outcome; Viral Load | 2014 |
Synergistic activity of tenofovir and nevirapine combinations released from polycaprolactone matrices for potential enhanced prevention of HIV infection through the vaginal route.
Topics: Adenine; Anti-HIV Agents; Drug Administration Routes; Drug Synergism; Drug Therapy, Combination; Female; HIV Infections; Humans; Microscopy, Electron, Scanning; Nevirapine; Organophosphonates; Polyesters; Tenofovir; Vagina | 2014 |
Decline in intrahepatic cccDNA and increase in immune cell reactivity after 12 weeks of antiviral treatment were associated with HBeAg loss.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Enzyme-Linked Immunospot Assay; Female; Hepatitis B Antigens; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Immunohistochemistry; Interferon-gamma; Killer Cells, Natural; Liver; Male; Organophosphonates; Real-Time Polymerase Chain Reaction; T-Lymphocytes; Viral Load; Young Adult | 2014 |
Kinetics of serum HBsAg in Chinese patients with chronic HBV infection with long-term adefovir dipivoxil treatment.
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies | 2014 |
Tenofovir disoproxil fumarate rescue therapy for HBV recurrence in two liver transplant recipients with previous multiple nucleo(s/t)ide treatment failures.
Topics: Adenine; Aged; Follow-Up Studies; Graft Rejection; Graft Survival; Hepatitis B; Humans; Liver Failure; Liver Function Tests; Liver Transplantation; Male; Nucleotides; Organophosphonates; Recurrence; Retreatment; Risk Assessment; Tenofovir; Transplant Recipients; Treatment Failure; Treatment Outcome | 2014 |
A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Data Collection; Deoxycytidine; Drug Combinations; Drug Utilization; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Europe; Female; HIV Infections; Humans; Male; Organophosphonates; Oxazines; Prospective Studies | 2014 |
Switching from tenofovir/emtricitabine and nevirapine to a tenofovir/emtricitabine/rilpivirine single-tablet regimen in virologically suppressed, HIV-1-infected subjects.
Topics: Adenine; Adult; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Drug Combinations; Drug Substitution; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nevirapine; Nitriles; Organophosphonates; Prospective Studies; Pyrimidines; Rilpivirine; Tenofovir; Treatment Outcome; Viral Load | 2014 |
Switching STRATEGIES in HIV treatment.
Topics: Adenine; Anti-HIV Agents; Carbamates; Cobicistat; Deoxycytidine; Emtricitabine; Female; HIV; HIV Infections; Humans; Male; Organophosphonates; Protease Inhibitors; Quinolones; Reverse Transcriptase Inhibitors; Ritonavir; Tenofovir; Thiazoles | 2014 |
New nucleos(t)ide analogue monoprophylaxis after cessation of hepatitis B immunoglobulin is effective against hepatitis B recurrence.
Topics: Adenine; Adult; Cohort Studies; Female; Follow-Up Studies; Graft Rejection; Graft Survival; Guanine; Hepatitis B, Chronic; Humans; Immunoglobulins; Immunosuppressive Agents; Liver Cirrhosis; Liver Transplantation; Male; Organophosphonates; Prospective Studies; Recurrence; Retreatment; Risk Assessment; Statistics, Nonparametric; Tenofovir; Transplantation Immunology; Treatment Outcome | 2014 |
A chronic kidney disease risk score to determine tenofovir safety in a prospective cohort of HIV-positive male veterans.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Prospective Studies; Renal Insufficiency, Chronic; Risk Assessment; Tenofovir; Veterans | 2014 |
Tenofovir in HIV-infected children. Antiretroviral efficacy, but beware of adverse effects on bone and the kidneys.
Topics: Adenine; Anti-HIV Agents; Bone Diseases; Child; Dose-Response Relationship, Drug; HIV Infections; Humans; Kidney Diseases; Medication Errors; Organophosphonates; Tenofovir | 2014 |
Self-assembled drug delivery systems. Part 7: hepatocyte-targeted nanoassemblies of an adefovir lipid derivative with cytochrome P450-triggered drug release.
Topics: Adenine; Animals; Antiviral Agents; Cytochrome P-450 Enzyme System; Drug Delivery Systems; Hepatitis B; Hepatocytes; Liver; Male; Mice, Inbred C57BL; Mice, Nude; Nanostructures; Organophosphonates; Polymers; Prodrugs; Tissue Distribution | 2014 |
An HBV-HIV co-infected patient treated with tenofovir-based therapy who achieved HBs antigen/antibody seroconversion.
Topics: Adenine; Adolescent; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Coinfection; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; HIV Infections; Humans; Male; Organophosphonates; Tenofovir | 2014 |
Pharmacokinetics and preliminary safety study of pod-intravaginal rings delivering antiretroviral combinations for HIV prophylaxis in a macaque model.
Topics: Adenine; Administration, Intravaginal; Animals; Anti-HIV Agents; Delayed-Action Preparations; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Macaca; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies | 2014 |
Evaluation of atazanavir and darunavir interactions with lipids for developing pH-responsive anti-HIV drug combination nanoparticles.
Topics: Adenine; Animals; Anti-HIV Agents; Atazanavir Sulfate; Darunavir; Delayed-Action Preparations; Drug Combinations; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Lipids; Macaca nemestrina; Oligopeptides; Organophosphonates; Pyridines; Sulfonamides; Tenofovir | 2014 |
Moving away from Ritonavir, Abacavir, Tenofovir, and Efavirenz (RATE)--agents that concern prescribers and patients: a feasibility study and call for a trial.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Clinical Trials as Topic; Cyclohexanes; Cyclopropanes; Dideoxynucleosides; Feasibility Studies; Female; Humans; Male; Maraviroc; Middle Aged; Organophosphonates; Ritonavir; Tenofovir; Triazoles | 2014 |
Delivery of multipurpose prevention drug combinations from electrospun nanofibers using composite microarchitectures.
Topics: Adenine; Anti-HIV Agents; Cell Survival; Contraceptive Agents, Female; Diffusion; Drug Combinations; Drug Design; Electroplating; HeLa Cells; HIV-1; Humans; Levonorgestrel; Nanocomposites; Nanofibers; Organophosphonates; Rotation; Tenofovir | 2014 |
Telbivudine plus tenofovir in combination therapy in patients with chronic hepatitis B infection--an Indian experience.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; India; Male; Middle Aged; Organophosphonates; Telbivudine; Tenofovir; Thymidine | 2013 |
Pharmacokinetics of atazanavir/ritonavir among HIV-infected Thai children concomitantly taking tenofovir disoproxil fumarate.
Topics: Adenine; Adolescent; Anti-HIV Agents; Asian People; Atazanavir Sulfate; Child; Female; HIV Infections; Humans; Lamivudine; Male; Oligopeptides; Organophosphonates; Pyridines; Ritonavir; Tenofovir | 2014 |
Investigation into drug-resistant mutations of HBV from 845 nucleoside/nucleotide analogue-naive Chinese patients with chronic HBV infection.
Topics: Adenine; Adult; Antiviral Agents; China; Clone Cells; Drug Resistance, Viral; Female; Gene Expression; Genotype; Guanine; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Phenotype; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Viral Proteins | 2015 |
Adefovir and lamivudine combination therapy in patients with entecavir-resistant chronic hepatitis B: antiviral responses and evolution of mutations.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Prospective Studies; Serum; Treatment Outcome; Viral Load | 2014 |
Pre-exposure prophylaxis accessibility research and evaluation (PrEPARE Study).
Topics: Adenine; Adult; Anti-HIV Agents; Antiviral Agents; California; Deoxycytidine; Emtricitabine; Health Expenditures; Health Knowledge, Attitudes, Practice; Health Services Accessibility; Health Surveys; HIV Infections; Homosexuality, Male; Humans; Male; Middle Aged; Organophosphonates; Patient Acceptance of Health Care; Pre-Exposure Prophylaxis; Tenofovir; Unsafe Sex | 2014 |
Effect of prophylactic versus preemptive lamivudine treatment and tenofovir on HBsAg+ kidney transplant recipients.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Drug Administration Schedule; Female; Graft Survival; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Transplantation; Lamivudine; Male; Organophosphonates; Retrospective Studies; Tenofovir; Time Factors; Treatment Outcome; Virus Replication | 2015 |
HBsAg clearance by Peg-interferon addition to a long-term nucleos(t)ide analogue therapy.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Interferon-alpha; Lamivudine; Male; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Time Factors; Treatment Outcome; Viral Load | 2014 |
Development of HIV-1 rectal-specific microbicides and colonic tissue evaluation.
Topics: Adenine; Adult; Anilides; Anti-Infective Agents, Local; Colon; Drug Evaluation, Preclinical; Drug Stability; Furans; HIV Infections; HIV-1; Humans; Hydrogels; Middle Aged; Organophosphonates; Semen; Tenofovir; Thioamides; Virus Replication; Young Adult | 2014 |
Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility.
Topics: Adenine; Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Child; China; Cohort Studies; DNA Replication; Drug Resistance, Viral; Female; Genes, Viral; Hep G2 Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Virus Replication; Young Adult | 2014 |
Rescue therapy with adefovir in decompensated liver cirrhosis patients with lamivudine-resistant hepatitis B virus.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Odds Ratio; Organophosphonates; Retrospective Studies; Severity of Illness Index; Survival Rate | 2014 |
Antiviral therapy of chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Liver Cirrhosis; Liver Neoplasms; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Telbivudine; Tenofovir; Thymidine; Treatment Outcome; Virus Replication | 2014 |
Reduction of infectivity in chronic hepatitis B virus carriers among healthcare providers and pregnant women by antiviral therapy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Female; Guanine; Health Personnel; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infectious Disease Transmission, Professional-to-Patient; Infectious Disease Transmission, Vertical; Lamivudine; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Telbivudine; Tenofovir; Thymidine; Viral Load; Viremia | 2014 |
Effect of antiretroviral HIV therapy on hepatitis B virus replication and pathogenicity.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Coinfection; Deoxycytidine; Emtricitabine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HIV Infections; HIV Reverse Transcriptase; HIV Seropositivity; HIV-1; Humans; Inflammation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; tat Gene Products, Human Immunodeficiency Virus; Tenofovir; Virus Replication; vpr Gene Products, Human Immunodeficiency Virus | 2014 |
Mechanisms of hepatitis B virus resistance development.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Deoxycytidine; Drug Resistance, Multiple, Viral; Emtricitabine; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Telbivudine; Tenofovir; Thymidine; Virus Replication | 2014 |
Hepatitis B virus drug resistance tools: one sequence, two predictions.
Topics: Adenine; Antiviral Agents; Base Sequence; Drug Resistance, Multiple, Viral; Genotype; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immune Evasion; Lamivudine; Microbial Sensitivity Tests; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Telbivudine; Tenofovir; Thymidine | 2014 |
The role of tenofovir in preventing and treating hepatitis B virus (HBV) reactivation in immunosuppressed patients. A real life experience from a tertiary center.
Topics: Adenine; Aged; Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Female; Hepatitis B; Humans; Immunocompromised Host; Immunologic Factors; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Organophosphonates; Rituximab; Tenofovir; Virus Activation | 2014 |
Virologic breakthrough in a patient with chronic hepatitis B by combination treatment with tenofovir disoproxil fumarate and entecavir.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2014 |
Safety and efficacy of coformulated efavirenz/emtricitabine/tenofovir single-tablet regimen in treatment-naive patients infected with HIV-1.
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; CD4 Lymphocyte Count; Cyclopropanes; Deoxycytidine; Drug Combinations; Drug-Related Side Effects and Adverse Reactions; Emtricitabine; Europe; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Organophosphonates; Plasma; Tablets; Tenofovir; Treatment Outcome; Viral Load | 2015 |
More on hepatitis B virus rtI233V mutation and resistance to adefovir.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; RNA-Directed DNA Polymerase | 2014 |
More on hepatitis B virus rtI233V mutation and resistance to adefovir.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Organophosphonates; RNA-Directed DNA Polymerase | 2014 |
Formulation and characterization of polymeric films containing combinations of antiretrovirals (ARVs) for HIV prevention.
Topics: Adenine; Administration, Intravaginal; Administration, Topical; Anti-HIV Agents; Chemistry, Pharmaceutical; Drug Carriers; Drug Combinations; Drug Delivery Systems; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Polymers; Pyrimidines; Tenofovir; Vagina | 2015 |
Synthesis of {[5-(adenin-9-yl)-2-furyl]methoxy}methyl phosphonic acid and evaluations against human adenylate kinases.
Topics: Adenine; Adenylate Kinase; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; Organophosphonates; Structure-Activity Relationship | 2014 |
The combined anti-HIV-1 activities of emtricitabine and tenofovir plus the integrase inhibitor elvitegravir or raltegravir show high levels of synergy in vitro.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Synergism; Emtricitabine; Integrase Inhibitors; Organophosphonates; Pyrrolidinones; Quinolones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Tenofovir | 2014 |
[A case of chronic hepatitis B managed with continued adefovir despite treatment-related Fanconi syndrome and osteomalacia].
Topics: Adenine; Fanconi Syndrome; Female; Hepatitis B, Chronic; Humans; Middle Aged; Organophosphonates; Osteomalacia | 2014 |
Proximal renal tubular dysfunction related to antiretroviral therapy among HIV-infected patients in an HIV clinic in Mexico.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Dideoxynucleosides; Drug Therapy, Combination; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney Tubules, Proximal; Longitudinal Studies; Male; Mexico; Middle Aged; Organophosphonates; Prospective Studies; Protease Inhibitors; Proteinuria; Tenofovir | 2015 |
Long-acting three-drug combination anti-HIV nanoparticles enhance drug exposure in primate plasma and cells within lymph nodes and blood.
Topics: Adenine; Animals; Anti-HIV Agents; Blood Cells; Drug Carriers; Drug Combinations; Lopinavir; Lymph Nodes; Macaca nemestrina; Nanoparticles; Organophosphonates; Plasma; Ritonavir; Tenofovir | 2014 |
Use of micellar liquid chromatography to analyze darunavir, ritonavir, emtricitabine, and tenofovir in plasma.
Topics: Adenine; Anti-HIV Agents; Calibration; Chromatography, Liquid; Darunavir; Deoxycytidine; Emtricitabine; Humans; Micelles; Organophosphonates; Ritonavir; Sodium Dodecyl Sulfate; Sulfonamides; Tenofovir | 2014 |
HIV pre-exposure prophylaxis: mucosal tissue drug distribution of RT inhibitor Tenofovir and entry inhibitor Maraviroc in a humanized mouse model.
Topics: Adenine; Animals; Anti-HIV Agents; Cyclohexanes; Disease Models, Animal; Female; HIV Infections; HIV-1; Humans; Maraviroc; Mice; Mucous Membrane; Organophosphonates; Pre-Exposure Prophylaxis; Reverse Transcriptase Inhibitors; Tenofovir; Triazoles; Virus Internalization | 2014 |
Treatment cessation in noncirrhotic, e-antigen negative chronic hepatitis B is safe and effective following prolonged anti-viral suppression with nucleosides/nucleotides.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Recurrence; Tenofovir; Withholding Treatment; Young Adult | 2014 |
Efficacy of prolonged tenofovir therapy on hepatitis delta in HIV-infected patients.
Topics: Adenine; Adult; Antiviral Agents; Hepatitis D, Chronic; HIV Infections; Humans; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Retrospective Studies; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2014 |
Initiation of rilpivirine, tenofovir and emtricitabine (RPV/TDF/FTC) regimen in 363 patients with virological vigilance assessment in 'real life'.
Topics: Adenine; Adult; Anti-HIV Agents; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Genotype; HIV; HIV Infections; Humans; Microbial Sensitivity Tests; Nitriles; Organophosphonates; Pyrimidines; Rilpivirine; Tenofovir | 2014 |
Switching to emtricitabine, tenofovir and rilpivirine as single tablet regimen in virologically suppressed HIV-1-infected patients: a cohort study.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Cohort Studies; Deoxycytidine; Drug Combinations; Drug Substitution; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Nitriles; Organophosphonates; Pyrimidines; Retrospective Studies; Rilpivirine; RNA, Viral; Tenofovir; Treatment Outcome; Viral Load | 2015 |
The rtA181S mutation of hepatitis B virus primarily confers resistance to adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Female; Genes, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; Virus Replication; Young Adult | 2015 |
Effects of tenofovir on cytokines and nucleotidases in HIV-1 target cells and the mucosal tissue environment in the female reproductive tract.
Topics: 5'-Nucleotidase; Adenine; Adult; Aged; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cell Survival; Cells, Cultured; Cervix Uteri; Chemokine CCL20; Cytokines; Endometrium; Epithelial Cells; Female; Fibroblasts; Gene Expression; HIV-1; Humans; Interleukin-8; Lipopolysaccharide Receptors; Middle Aged; Mucous Membrane; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Tumor Necrosis Factor-alpha | 2014 |
Prophylactic treatment with a novel bioadhesive gel formulation containing aciclovir and tenofovir protects from HSV-2 infection.
Topics: Acrylic Resins; Acyclovir; Adenine; Animals; Anti-Infective Agents; Chlorocebus aethiops; Disease Models, Animal; Drug-Related Side Effects and Adverse Reactions; Female; Herpes Genitalis; Herpesvirus 2, Human; Mice, Inbred BALB C; Organophosphonates; Poloxamer; Rabbits; Rats, Sprague-Dawley; Tenofovir; Treatment Outcome; Vaginal Creams, Foams, and Jellies; Vero Cells | 2014 |
Efficacy and safety of tenofovir in a kidney transplant patient with chronic hepatitis B and nucleos(t)ide multidrug resistance: a case report.
Topics: Adenine; Antiviral Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Kidney Transplantation; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir; Treatment Outcome; Viral Load | 2014 |
[Case report; Fanconi's syndrome and hypophosphatemic osteomalacia associated with adefovir dipivoxil: a case report].
Topics: Adenine; Aged; Antiviral Agents; Fanconi Anemia; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia; Treatment Outcome | 2014 |
Efficacy of entecavir-tenofovir combination therapy for chronic hepatitis B patients with multidrug-resistant strains.
Topics: Adenine; Adult; Aged; Antiviral Agents; Base Sequence; Cohort Studies; DNA, Viral; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Sequence Analysis, DNA; Tenofovir; Treatment Outcome; Viral Load; Young Adult | 2014 |
Predicting pediatric age-matched weight and body mass index.
Topics: Adenine; Adolescent; Aging; Body Mass Index; Body Weight; Child; Child, Preschool; Computer Simulation; Female; Humans; Infant; Infant, Newborn; Male; Models, Biological; Models, Statistical; Organophosphonates; Predictive Value of Tests; Software; Tenofovir | 2014 |
Assessment of bone mineral density in tenofovir-treated patients with chronic hepatitis B: can the fracture risk assessment tool identify those at greatest risk?
Topics: Adenine; Adult; Body Mass Index; Bone Density; Cross-Sectional Studies; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Risk; Risk Assessment; Tenofovir | 2015 |
Safety and efficacy of entecavir in adefovir-experienced patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Drug Substitution; Female; Follow-Up Studies; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2015 |
Manufacturing scale-up of electrospun poly(vinyl alcohol) fibers containing tenofovir for vaginal drug delivery.
Topics: Adenine; Administration, Intravaginal; Anti-HIV Agents; Dosage Forms; Drug Delivery Systems; Female; HIV-1; Humans; Organophosphonates; Polyvinyl Chloride; Reverse Transcriptase Inhibitors; Tenofovir; Vagina | 2014 |
[Efficacy of 48-week tenofovir disoproxil fumarate therapy in patients who were unresponsive to nucleoside-analogue treatments].
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Young Adult | 2014 |
Adefovir as a possible teratogen: evidence from paternal exposure.
Topics: Adenine; Adult; Antiviral Agents; Female; Heart Defects, Congenital; Humans; Male; Organophosphonates; Paternal Exposure; Pregnancy; Teratogens; Ultrasonography, Prenatal | 2014 |
Differential binding of tenofovir and adefovir to reverse transcriptase of hepatitis B virus.
Topics: Adenine; Adenosine Triphosphate; Binding Sites; Cluster Analysis; Crystallography, X-Ray; Deoxyguanine Nucleotides; Drug Resistance, Viral; Hepatitis B virus; Ligands; Models, Molecular; Mutation; Nucleotides; Open Reading Frames; Organophosphonates; Protein Binding; RNA-Directed DNA Polymerase; Tenofovir; Thermodynamics | 2014 |
Incidence and predictors of hepatocellular carcinoma in Caucasian chronic hepatitis B patients receiving entecavir or tenofovir.
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; Female; Follow-Up Studies; Greece; Guanine; Hepatitis B, Chronic; Humans; Incidence; Liver Neoplasms; Male; Middle Aged; Netherlands; Organophosphonates; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Spain; Tenofovir; Time Factors; Turkey; White People | 2015 |
A clinical prediction tool for targeted pre-antiretroviral therapy creatinine testing applied to the TREAT Asia HIV observational database cohort.
Topics: Adenine; Anti-HIV Agents; Clinical Medicine; Creatinine; Decision Support Techniques; Female; HIV Infections; Humans; Kidney Diseases; Male; Organophosphonates | 2014 |
[Retrospective analysis of the efficacy and safety of anti-hepatitis B virus drugs taken during pregnancy in women from the Guangdong Province].
Topics: Adenine; Antiviral Agents; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Male; Mothers; Organophosphonates; Pregnancy; Retrospective Studies; Telbivudine; Thymidine; Time Factors | 2014 |
Assessing adherence to the 2010 antiretroviral guidelines at the antiretroviral rollout clinic in 1 military hospital, South Africa: a retrospective, cross sectional study.
Topics: Adenine; Adult; Anti-Retroviral Agents; Cross-Sectional Studies; Drug Monitoring; Drug Substitution; Female; Guideline Adherence; HIV Infections; Hospitals, Military; Humans; Male; Organophosphonates; Outcome Assessment, Health Care; Practice Guidelines as Topic; Practice Patterns, Physicians'; Retrospective Studies; South Africa; Stavudine; Tenofovir | 2014 |
Chronic hepatitis B virus coinfection is associated with renal impairment among Zambian HIV-infected adults.
Topics: Adenine; Adolescent; Adult; Africa; Anti-HIV Agents; Coinfection; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; HIV; Humans; Male; Middle Aged; Organophosphonates; Renal Insufficiency; Tenofovir; Young Adult | 2014 |
First report of successful clearance of hepatitis B and D coinfection with tenofovir monotherapy.
Topics: Adenine; Adult; Coinfection; Hepatitis B; Hepatitis D; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2015 |
High prevalence of signs of renal damage despite normal renal function in a cohort of HIV-infected patients: evaluation of associated factors.
Topics: Adenine; Adult; Age Factors; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Cross-Sectional Studies; Diabetes Mellitus; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hypertension; Kidney; Kidney Diseases; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Prevalence; Prospective Studies; Risk Factors; Socioeconomic Factors; Spain; Surveys and Questionnaires; Tenofovir; Viral Load | 2014 |
Long-term treatment with tenofovir in Asian-American chronic hepatitis B patients is associated with abnormal renal phosphate handling.
Topics: Absorptiometry, Photon; Adenine; Adult; Aged; Antiviral Agents; Asian People; Bone Density; Cross-Sectional Studies; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney Tubules, Proximal; Male; Middle Aged; Organophosphonates; Osteoporosis; Phosphates; Prospective Studies; Renal Reabsorption; Risk Factors; Tenofovir; Time Factors; Treatment Outcome; Young Adult | 2015 |
Efficacy of adefovir dipivoxil combined with a corticosteroid in 38 cases of nephrotic syndrome induced by hepatitis B virus-associated glomerulonephritis.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Glomerulonephritis; Glucocorticoids; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nephrotic Syndrome; Organophosphonates; Treatment Outcome; Young Adult | 2014 |
The feasibility of discontinuing lamivudine in lamivudine-resistant chronic hepatitis B patients on lamivudine and adefovir combination therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Feasibility Studies; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Retrospective Studies; Treatment Outcome; Young Adult | 2014 |
Long-term exposure to tenofovir continuously decrease renal function in HIV-1-infected patients with low body weight: results from 10 years of follow-up.
Topics: Adenine; Adult; Anti-HIV Agents; Body Weight; Cohort Studies; Female; Glomerular Filtration Rate; HIV Infections; HIV-1; Humans; Longitudinal Studies; Male; Organophosphonates; Renal Insufficiency; Tenofovir; Tokyo | 2014 |
Skeletal muscle toxicity associated with emtricitabine/rilpivirine/tenofovir fixed-dose combination: a case report.
Topics: Adenine; Deoxycytidine; Drug Combinations; Emtricitabine; Histocytochemistry; Humans; Lipodystrophy; Male; Microscopy; Middle Aged; Muscle, Skeletal; Muscular Atrophy, Spinal; Nitriles; Organophosphonates; Pyrimidines; Rilpivirine; Tenofovir | 2014 |
Infection with the frequently transmitted HIV-1 M41L variant has no influence on selection of tenofovir resistance.
Topics: Adenine; Adult; Amino Acid Substitution; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Deoxycytidine; Drug Resistance, Viral; Emtricitabine; Evolution, Molecular; Female; Genotype; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Phenotype; Phylogeny; Reverse Transcriptase Inhibitors; Tenofovir; Viral Load | 2015 |
Lopinavir/r no longer recommended as a first-line regimen: a comparative effectiveness analysis.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cohort Studies; Deoxycytidine; Emtricitabine; Female; France; HIV Infections; Humans; Lopinavir; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Failure; Viral Load | 2014 |
Tenofovir-associated Fanconi syndrome in a patient with chronic hepatitis B.
Topics: Adenine; Aged, 80 and over; Antiviral Agents; Fanconi Syndrome; Fatal Outcome; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Risk Factors; Tenofovir | 2014 |
Long-term outcomes and dynamics of mutants associated with lamivudine-adefovir rescue therapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA-Directed DNA Polymerase; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Viral Load; Young Adult | 2015 |
Liver biopsy interpretation & the regression of hepatitis B virus related cirrhosis.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Biomarkers; Biopsy; Hepatitis B, Chronic; Humans; India; Liver Cirrhosis; Organophosphonates; Tenofovir; Treatment Outcome | 2014 |
When is good good enough for HIV-1 prophylaxis?
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Organophosphonates; Pre-Exposure Prophylaxis; Tenofovir | 2014 |
Different mechanism of selection of adefovir-resistant mutant viruses during adefovir monotherapy in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation Rate; Mutation, Missense; Organophosphonates; Point Mutation; Retrospective Studies; RNA-Directed DNA Polymerase; Selection, Genetic; Young Adult | 2014 |
The incidence of hepatocellular carcinoma is reduced in patients with chronic hepatitis B on long-term nucleos(t)ide analogue therapy.
Topics: Adenine; Adult; Antiviral Agents; Canada; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Incidence; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Nucleosides; Organophosphonates; Retrospective Studies; Risk Factors; Telbivudine; Tenofovir; Thymidine | 2014 |
Editorial commentary: the conundrum of Lamivudine and tenofovir disoproxil fumarate for hepatitis B: fetus versus infant.
Topics: Adenine; Anti-HIV Agents; Breast Feeding; Disease Transmission, Infectious; Female; Hepatitis B; Humans; Lamivudine; Organophosphonates; Pregnancy | 2015 |
Tenofovir disoproxil fumarate monotherapy for nucleos(t)ide-naïve chronic hepatitis B patients in Korea: data from the clinical practice setting in a single-center cohort.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Antiviral Agents; Cohort Studies; DNA, Viral; Female; Gastrointestinal Diseases; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Republic of Korea; Retrospective Studies; Tenofovir; Treatment Outcome; Young Adult | 2014 |
Long-term outcomes of two rescue therapies in lamivudine-refractory patients with chronic hepatitis B: combined lamivudine and adefovir, and 1-mg entecavir.
Topics: Adenine; Adult; Aged; Alanine Transaminase; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Treatment Outcome | 2014 |
Evaluation of the efficacy and safety of switching to tenofovir, emtricitabine, and rilpivirine in treatment-experienced patients.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; HIV Infections; Humans; Male; Middle Aged; Nitriles; Organophosphonates; Pyrimidines; Rilpivirine; Tenofovir; Young Adult | 2015 |
[Clinical pathology of recurrent hepatitis B after liver transplantation].
Topics: Adenine; Antiviral Agents; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Liver Transplantation; Organophosphonates; Recurrence | 2014 |
[To evaluate the changes in body composition in male human immunodeficiency virus-related lipodystrophy after different treatment regimens by dual-energy X-ray absorptiometry].
Topics: Absorptiometry, Photon; Adenine; Anti-HIV Agents; Antiviral Agents; Body Composition; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Male; Organophosphonates; Stavudine; Tenofovir; Zidovudine | 2014 |
Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.
Topics: Adenine; Administration, Intravaginal; Animals; Anti-HIV Agents; Drug Delivery Systems; Female; HIV; Lentivirus Infections; Macaca nemestrina; Organophosphonates; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Vagina | 2014 |
Dolutegravir efficacy at 48 weeks in key subgroups of treatment-naive HIV-infected individuals in three randomized trials.
Topics: Adenine; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Clinical Trials, Phase III as Topic; Coinfection; Deoxycytidine; Dideoxynucleosides; Drug Combinations; Emtricitabine; Female; Heterocyclic Compounds, 3-Ring; HIV Infections; HIV Integrase Inhibitors; HIV Protease Inhibitors; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Oxazines; Piperazines; Pyridones; Pyrrolidinones; Raltegravir Potassium; Randomized Controlled Trials as Topic; Regression Analysis; Retrospective Studies; Ritonavir; Tenofovir; Treatment Outcome; Viral Load | 2015 |
Perception of HIV risk and adherence to a daily, investigational pill for HIV prevention in FEM-PrEP.
Topics: Adenine; Adolescent; Adult; Anti-Retroviral Agents; Blood Chemical Analysis; Chemoprevention; Deoxycytidine; Disease Transmission, Infectious; Emtricitabine; Female; Health Knowledge, Attitudes, Practice; HIV Infections; Humans; Medication Adherence; Organophosphonates; Risk-Taking; Tenofovir; Young Adult | 2014 |
HIV testing in pregnancy.
Topics: Adenine; Anti-HIV Agents; Benzoxazines; Female; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Lamivudine; Nevirapine; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Rural Population | 2014 |
Anti-HIV drug-combination nanoparticles enhance plasma drug exposure duration as well as triple-drug combination levels in cells within lymph nodes and blood in primates.
Topics: Adenine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Carriers; Drug Combinations; HIV Infections; HIV Protease Inhibitors; HIV-1; Indinavir; Lipids; Lopinavir; Lymph Nodes; Macaca; Nanoparticles; Organophosphonates; Ritonavir; Tenofovir; Viral Load; Virus Latency | 2015 |
Tenofovir monotherapy versus tenofovir plus lamivudine or telbivudine combination therapy in treatment of lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome | 2015 |
Effect of Peg-interferon α-2a combined with Adefovir in HBV postpartum women with normal levels of ALT and high levels of HBV DNA.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Postpartum Period; Pregnancy; Prospective Studies; Recombinant Proteins; Telbivudine; Thymidine; Treatment Outcome | 2015 |
Renal impairment in HIV-infected patients initiating tenofovir-containing antiretroviral therapy regimens in a Primary Healthcare Setting in South Africa.
Topics: Adenine; Adult; Age Factors; Anemia; Anti-HIV Agents; CD4 Lymphocyte Count; Female; Glomerular Filtration Rate; HIV Infections; Humans; Kidney; Logistic Models; Male; Middle Aged; Organophosphonates; Prevalence; Primary Health Care; Renal Insufficiency; Reverse Transcriptase Inhibitors; South Africa; Tenofovir | 2015 |
Discovering novel direct acting antiviral agents for HBV using in silico screening.
Topics: Adenine; Albumins; Animals; Antiviral Agents; Binding Sites; Cells, Cultured; Chimera; Databases, Protein; Drug Design; Drug Discovery; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Ligands; Liver; Mice; Middle Aged; Molecular Docking Simulation; Organophosphonates; Protein Binding; Real-Time Polymerase Chain Reaction; Tenofovir | 2015 |
Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir.
Topics: Adenine; Antiviral Agents; Cidofovir; Cytosine; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Organic Anion Transport Protein 1; Organophosphonates; Tenofovir; Toxicity Tests | 2015 |
Tenofovir-induced Fanconi syndrome in chronic hepatitis B monoinfected patients that reverted after tenofovir withdrawal.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome; Viral Load; Withholding Treatment | 2014 |
Elvitegravir/cobicistat/emtricitabine/tenofovir DF in HIV-infected patients with mild-to-moderate renal impairment.
Topics: Adenine; Adult; Anti-HIV Agents; Carbamates; Cobicistat; Cohort Studies; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Quinolones; Renal Insufficiency; Tenofovir; Thiazoles; Treatment Outcome | 2015 |
Efficacy of adefovir dipivoxil therapy in patients with chronic hepatitis B viral infection.
Topics: Adenine; Adult; Antiviral Agents; Bangladesh; Drug Monitoring; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Function Tests; Male; Middle Aged; Monitoring, Immunologic; Organophosphonates; Prospective Studies; Treatment Outcome | 2014 |
Nucleotide analogue-resistant mutations in hepatitis B viral genomes found in hepatitis B patients.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; DNA, Viral; Genome, Viral; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates | 2015 |
A pharmacogenetic candidate gene study of tenofovir-associated Fanconi syndrome.
Topics: Adenine; Alleles; Anti-HIV Agents; Biomarkers, Pharmacological; Case-Control Studies; Fanconi Syndrome; Genetic Association Studies; HEK293 Cells; HIV Infections; HIV-1; Humans; Multidrug Resistance-Associated Protein 2; Organophosphonates; Pharmacogenetics; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Tenofovir | 2015 |
Development of a composite measure of product adherence, protocol compliance, and semen exposure using DNA and protein biomarkers for topical HIV prevention studies.
Topics: Adenine; Administration, Topical; Adult; Anti-HIV Agents; Biomarkers; Cellulose; DNA; Environmental Exposure; Feasibility Studies; Female; Guideline Adherence; HIV Infections; Humans; Keratin-4; Male; Middle Aged; Organophosphonates; Outcome Assessment, Health Care; Patient Compliance; Semen; Tenofovir; Vagina; Young Adult | 2014 |
Tenofovir during pregnancy in rats: a novel pathway for programmed hypertension in the offspring.
Topics: Adenine; Animals; Antiviral Agents; Biological Transport, Active; Female; Hypertension; Models, Animal; Organophosphonates; Pregnancy; Rats, Wistar; Renin-Angiotensin System; Sodium; Tenofovir | 2015 |
Resistant mutants induced by adefovir dipivoxil in hepatitis B virus isolates.
Topics: Adenine; Adult; Antiviral Agents; Chi-Square Distribution; Cross-Sectional Studies; Diagnostic Imaging; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Mutation; Organophosphonates; Predictive Value of Tests; Risk Factors; Time Factors; Treatment Outcome | 2014 |
Do we need more nucleos(t)ide analogs for the treatment of chronic hepatitis B?
Topics: Adenine; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Organophosphonates | 2015 |
High interest in preexposure prophylaxis among men who have sex with men at risk for HIV infection: baseline data from the US PrEP demonstration project.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Chemoprevention; Cohort Studies; Deoxycytidine; Disease Transmission, Infectious; Emtricitabine; HIV Infections; Homosexuality, Male; Humans; Longitudinal Studies; Male; Organophosphonates; Patient Acceptance of Health Care; Pre-Exposure Prophylaxis; Prospective Studies; Tenofovir; United States; Young Adult | 2015 |
Models for predicting effective HIV chemoprevention in women.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Cell Culture Techniques; Cell Survival; Chemoprevention; Chromatography, Liquid; Cyclohexanes; Disease Transmission, Infectious; Dose-Response Relationship, Drug; Female; HIV Infections; Humans; Maraviroc; Middle Aged; Organ Culture Techniques; Organophosphonates; Tandem Mass Spectrometry; Tenofovir; Triazoles; Vagina; Viral Load; Young Adult | 2015 |
[Tenofovir rescue therapy for chronic hepatitis B patients after suboptimal response to treatment with lamivudine plus adefovir dipivoxil].
Topics: Adenine; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Failure; Treatment Outcome | 2014 |
Postexposure prophylactic effect of hepatitis B virus (HBV)-active antiretroviral therapy against HBV infection.
Topics: Adenine; Animals; Antiviral Agents; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Mice; Organophosphonates; Retrospective Studies; Tenofovir | 2015 |
Quiz Page January 2015: acute kidney injury in a patient with well-controlled HIV infection.
Topics: Acute Kidney Injury; Adenine; Aged, 80 and over; Anti-HIV Agents; Biopsy; CD4 Lymphocyte Count; Diagnosis, Differential; Diarrhea; HIV Infections; Humans; Hypertension; Immunologic Tests; Kidney; Kidney Function Tests; Male; Monitoring, Physiologic; Organophosphonates; Ritonavir; Tenofovir; Treatment Outcome; Viral Load; Withholding Treatment | 2015 |
Bone and kidney toxicity induced by nucleotide analogues in patients affected by HBV-related chronic hepatitis: a longitudinal study.
Topics: Adenine; Adult; Aged; Antiviral Agents; Bone Diseases; Drug-Related Side Effects and Adverse Reactions; Female; Glomerular Filtration Rate; Hematuria; Hepatitis B, Chronic; Humans; Hypophosphatemia; Kidney Diseases; Lamivudine; Longitudinal Studies; Male; Middle Aged; Organophosphonates; Proteinuria; Vitamin D Deficiency | 2015 |
Preexposure prophylaxis: a path forward.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; HIV-1; Humans; Kidney Glomerulus; Male; Organophosphonates; Tenofovir | 2015 |
Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing.
Topics: Adenine; Cell Line; Epithelium; Gene Expression Regulation; Humans; Hypoxia; Kidney Diseases; Kidney Tubules, Proximal; Organophosphonates; Oxygen; Protein Array Analysis; Reverse Transcriptase Inhibitors; Toxicity Tests; Xenobiotics | 2015 |
Modulating the dehydration conditions of adefovir dipivoxil dihydrate to obtain different physical forms of anhydrate.
Topics: Adenine; Administration, Oral; Antiviral Agents; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Desiccation; Drug Stability; Organophosphonates; Powder Diffraction; Technology, Pharmaceutical; Transition Temperature; Volatilization; Water | 2015 |
[Promotion of HBeAg seroconversion/loss in patients with chronic hepatitis B following the switch from nucleoside drugs to telbivudine and adefovir].
Topics: Adenine; Drug Combinations; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Nucleic Acid Synthesis Inhibitors; Nucleosides; Organophosphonates; Telbivudine; Thymidine | 2014 |
[Hypophosphatemic osteomalacia and renal Fanconi syndrome induced by adefovir in a patient with chronic hepatitis B].
Topics: Adenine; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia | 2014 |
No relationship between drug transporter genetic variants and tenofovir plasma concentrations or changes in glomerular filtration rate in HIV-infected adults.
Topics: Adenine; Adult; Anti-HIV Agents; Cohort Studies; Female; Genotype; Glomerular Filtration Rate; HIV Infections; Humans; Male; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organophosphonates; Plasma; Retrospective Studies; Tenofovir | 2015 |
[The clinical characteristics of 26 cases of hypophosphatemia osteomalacia misdiagnosed as spondyloarthritis].
Topics: Adenine; Adult; Antirheumatic Agents; Biomarkers; C-Reactive Protein; Fanconi Syndrome; Female; Humans; Hyperparathyroidism; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Platelet Count; Prognosis; Sjogren's Syndrome; Spondylarthritis; Young Adult | 2014 |
Pregnancy and contraceptive use among women participating in the FEM-PrEP trial.
Topics: Adenine; Adolescent; Adult; Anti-Retroviral Agents; Contraceptive Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Incidence; Medication Adherence; Organophosphonates; Plasma; Pregnancy; Pregnancy Rate; Pregnancy, Unplanned; Tenofovir; Young Adult | 2015 |
Isolation, LC-MS/MS and 2D-NMR characterization of alkaline degradants of tenofovir disoproxil fumarate.
Topics: Adenine; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Organophosphonates; Prodrugs; Sodium Hydroxide; Tandem Mass Spectrometry; Tenofovir | 2015 |
Commentary: The place of tenofovir disoproxil fumarate in pediatric antiretroviral therapy.
Topics: Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Drug Utilization; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV-1; Humans; Male; Organophosphonates; Stavudine; Zidovudine | 2015 |
Clinical trials. Renal safety of TDF as pre-exposure prophylaxis for HIV-1 infection.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; HIV-1; Humans; Kidney Glomerulus; Male; Organophosphonates | 2015 |
The efficacy and safety of tenofovir in the prevention of hepatitis B virus recurrence following liver transplantation.
Topics: Adenine; Antiviral Agents; End Stage Liver Disease; Female; Hepatitis B; Humans; Immunoglobulins; Liver Transplantation; Male; Middle Aged; Organophosphonates; Postoperative Complications; Recurrence; Retrospective Studies; Tenofovir; Treatment Outcome | 2014 |
Diminished impact of ethnicity as a risk factor for chronic kidney disease in the current HIV treatment era.
Topics: Adenine; Adult; Africa South of the Sahara; Anti-HIV Agents; Cross-Sectional Studies; Female; HIV Infections; Humans; Male; Middle Aged; Netherlands; Organophosphonates; Prevalence; Renal Insufficiency, Chronic; Risk Factors; Tenofovir | 2015 |
Response-guided treatment of cirrhotic chronic hepatitis B patients: multicenter prospective study.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; China; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Mutation; Organophosphonates; Prospective Studies; Time Factors; Treatment Outcome; Viral Load | 2015 |
Estimating the cost-effectiveness of pre-exposure prophylaxis to reduce HIV-1 and HSV-2 incidence in HIV-serodiscordant couples in South Africa.
Topics: Adenine; Anti-HIV Agents; Cost-Benefit Analysis; Couples Therapy; Family Characteristics; Female; HIV Seropositivity; HIV Seroprevalence; HIV-1; HIV-2; Humans; Male; Organophosphonates; Pre-Exposure Prophylaxis; South Africa; Tenofovir | 2015 |
HBV carrying drug-resistance mutations in chronically infected treatment-naive patients.
Topics: Adenine; Antibodies, Viral; Antiviral Agents; Brazil; DNA, Viral; Drug Resistance, Viral; Gene Products, pol; Genotype; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microbial Sensitivity Tests; Mutation; Organophosphonates; Retrospective Studies; Sequence Analysis, DNA; Tenofovir; Virus Replication | 2015 |
Preventing HIV in women--still trying to find their VOICE.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Pre-Exposure Prophylaxis; Tenofovir | 2015 |
[Case report; A case of Fanconi's syndrome with pathological ulnar fractures improved by dose reduction of adefovir and supplementation of oral phosphate].
Topics: Adenine; Administration, Oral; Aged; Antiviral Agents; Fanconi Syndrome; Female; Fractures, Spontaneous; Hepatitis B; Humans; Organophosphonates; Phosphates; Ulna | 2014 |
High prevalence of the K65R mutation in HIV-1 subtype C infected patients failing tenofovir-based first-line regimens in South Africa.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Drug Resistance, Viral; Female; Genotype; HIV Infections; HIV-1; Humans; Male; Middle Aged; Molecular Sequence Data; Mutation; Organophosphonates; Prevalence; South Africa; Tenofovir; Viral Load; Young Adult | 2015 |
Pre-exposure prophylaxis in women fails to prevent HIV infection in African study.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Pre-Exposure Prophylaxis | 2015 |
Selective Lewis acid catalyzed assembly of phosphonomethyl ethers: three-step synthesis of tenofovir.
Topics: Adenine; Catalysis; Dioxanes; Dioxolanes; Ethers; Ethylamines; Lewis Acids; Molecular Structure; Organophosphonates; Phosphines; Tenofovir | 2015 |
Renal tubular dysfunction associated with tenofovir therapy.
Topics: Adenine; Adult; Anti-HIV Agents; Creatinine; Developing Countries; Diagnosis, Differential; Female; HIV Infections; Humans; Incidence; India; Kidney Diseases; Kidney Tubules; Long-Term Care; Male; Middle Aged; Organophosphonates; Tenofovir | 2014 |
Low-dose short-term hepatitis B immunoglobulin with high genetic barrier antivirals: the ideal post-transplant hepatitis B virus prophylaxis?
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; Cohort Studies; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir | 2015 |
How does weight influence tenofovir disoproxil-fumarate induced renal function decline?
Topics: Adenine; Anti-HIV Agents; Body Weight; Female; Glomerular Filtration Rate; HIV Infections; Humans; Male; Organophosphonates; Renal Insufficiency | 2015 |
Reply to 'how does weight influence tenofovir disoproxil-fumarate induced renal function decline?'.
Topics: Adenine; Anti-HIV Agents; Body Weight; Female; Glomerular Filtration Rate; HIV Infections; Humans; Male; Organophosphonates; Renal Insufficiency | 2015 |
Comparison of the efficacies of entecavir 0.5 and 1.0 mg combined with adefovir in patients with chronic hepatitis B who had failed on prior nucleos(t)ide analogue treatments.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Republic of Korea; Retrospective Studies; Time Factors; Treatment Failure; Treatment Outcome; Viral Load; Young Adult | 2015 |
Analysis of HBV genotype, drug resistant mutations, and pre-core/basal core promoter mutations in Korean patients with acute hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B; Hepatitis B Core Antigens; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Promoter Regions, Genetic; Prospective Studies; Republic of Korea; Viral Core Proteins; Virus Replication | 2015 |
Antibody Maturation in Women Who Acquire HIV Infection While Using Antiretroviral Preexposure Prophylaxis.
Topics: Adenine; Adult; Anti-Retroviral Agents; Antibody Affinity; Cohort Studies; Female; HIV; HIV Antibodies; HIV Infections; Humans; Immunoassay; Organophosphonates; Pre-Exposure Prophylaxis; Randomized Controlled Trials as Topic; Tenofovir; Time Factors; Young Adult | 2015 |
Tenofovir rescue regimen following prior suboptimal response to entecavir and adefovir combination therapy in chronic hepatitis B patients exposed to multiple treatment failures.
Topics: Adenine; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; ROC Curve; Tenofovir; Treatment Failure; Treatment Outcome | 2015 |
Predictors of kidney tubular dysfunction induced by adefovir treatment for chronic hepatitis B.
Topics: Adenine; Adult; Age Factors; Aged; Aged, 80 and over; Antiviral Agents; Chi-Square Distribution; Female; Genetic Predisposition to Disease; Hepatitis B, Chronic; Humans; Japan; Kidney Diseases; Kidney Tubules, Proximal; Logistic Models; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Odds Ratio; Organic Anion Transport Protein 1; Organophosphonates; Osteomalacia; Polymorphism, Single Nucleotide; Prevalence; Retrospective Studies; Risk Factors; Time Factors | 2015 |
Osteomalacia and Fanconi's syndrome caused by long-term low-dose adefovir dipivoxil.
Topics: Adenine; Antiviral Agents; Calcium; Dose-Response Relationship, Drug; Drug Monitoring; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Male; Middle Aged; Musculoskeletal Pain; Organophosphonates; Osteomalacia; Phosphates; Time Factors | 2015 |
Tenofovir rescue therapy in pregnant females with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Apgar Score; Biomarkers; Birth Weight; China; DNA, Viral; Drug Resistance, Viral; Drug Substitution; Female; Genotype; Hepatitis B Vaccines; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Lamivudine; Live Birth; Male; Middle Aged; Mutation; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Time Factors; Treatment Outcome; Vaccination; Viral Load; Young Adult | 2015 |
Clinical course of chronic hepatitis B patients receiving nucleos(t)ide analogues after virological breakthrough during monotherapy with lamivudine.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome; Viral Load; Viral Matrix Proteins; Young Adult | 2015 |
Whole-body immunoPET reveals active SIV dynamics in viremic and antiretroviral therapy-treated macaques.
Topics: Adenine; Animals; Anti-Retroviral Agents; Copper Radioisotopes; Deoxycytidine; Emtricitabine; Immunohistochemistry; Male; Membrane Glycoproteins; Naphthyridines; Organophosphonates; Positron-Emission Tomography; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Simian Immunodeficiency Virus; Tenofovir; Viral Envelope Proteins; Viremia; Virus Replication; Whole Body Imaging | 2015 |
[Clinical emergence features and implications of hepatitis B virus rtA181T mutation].
Topics: Adenine; Antiviral Agents; China; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Mutation; Organophosphonates | 2015 |
[Pharmacoeconomic evaluation of treatments based on antiretrovirals for HBeAg-negative chronic hepatitis B].
Topics: Adenine; Antiviral Agents; China; Cost-Benefit Analysis; Economics, Pharmaceutical; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Polyethylene Glycols; Quality-Adjusted Life Years; Recombinant Proteins | 2015 |
Symmetrical diamidate prodrugs of nucleotide analogues for drug delivery.
Topics: Adenine; Antiviral Agents; Drug Delivery Systems; Humans; Nucleotides; Organophosphonates; Phosphorus Compounds; Prodrugs; Stavudine | 2015 |
Tenofovir disoproxil fumarate is superior to lamivudine plus adefovir in lamivudine-resistant chronic hepatitis B patients.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Substitution; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver Function Tests; Male; Medical Records; Middle Aged; Organophosphonates; Phosphorous Acids; Randomized Controlled Trials as Topic; Retrospective Studies; Time Factors; Treatment Outcome; Viral Load; Young Adult | 2015 |
Efficacy, safety and pharmacokinetics of tenofovir disoproxil fumarate in virologic-suppressed HIV-infected children using weight-band dosing.
Topics: Adenine; Adolescent; Alkynes; Anti-HIV Agents; Benzoxazines; Bone Density; Calcium; CD4 Lymphocyte Count; Child; Child, Preschool; Cyclopropanes; Drug-Related Side Effects and Adverse Reactions; Female; HIV Infections; HIV-1; Humans; Lamivudine; Male; Organophosphonates; Prospective Studies; RNA, Viral; Tenofovir; Treatment Outcome; Urinalysis; Viral Load | 2015 |
The science of being a study participant: FEM-PrEP participants' explanations for overreporting adherence to the study pills and for the whereabouts of unused pills.
Topics: Adenine; Adult; Clinical Trials as Topic; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Interviews as Topic; Kenya; Medication Adherence; Organophosphonates; South Africa; Tenofovir; Treatment Outcome | 2015 |
Reduced immune activation during tenofovir-emtricitabine therapy in HIV-negative individuals.
Topics: Adenine; Adolescent; Adult; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; Humans; Immunologic Factors; Lymphocyte Activation; Male; Middle Aged; Organophosphonates; Pre-Exposure Prophylaxis; Tenofovir; Young Adult | 2015 |
Water-compatible molecularly imprinted polymer as a sorbent for the selective extraction and purification of adefovir from human serum and urine.
Topics: Adenine; Humans; Hydrogen-Ion Concentration; Molecular Imprinting; Organophosphonates; Polymers; Reverse Transcriptase Inhibitors; Spectrophotometry, Infrared; Thermodynamics; Water | 2015 |
N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides.
Topics: Adenine; Base Sequence; DNA-Directed DNA Polymerase; Humans; Nucleic Acid Synthesis Inhibitors; Nucleosides; Oligonucleotides; Organophosphonates; Thymine | 2015 |
MRI visible drug eluting magnetic microspheres for transcatheter intra-arterial delivery to liver tumors.
Topics: Adenine; Alginates; Animals; Antineoplastic Agents; Disease Models, Animal; Drug Carriers; Glucuronic Acid; Hexuronic Acids; Injections, Intra-Arterial; Liver Neoplasms; Magnetic Resonance Imaging; Microspheres; Naphthalimides; Organophosphonates; Rats | 2015 |
Antiretroviral chemoprophylaxis: new successes and questions.
Topics: Adenine; Anti-HIV Agents; Anti-Retroviral Agents; Chemoprevention; Deoxycytidine; Drug Combinations; Emtricitabine; Gels; HIV Infections; Humans; Organophosphonates; Tenofovir | 2015 |
Limited hepatitis B immunoglobulin with potent nucleos(t)ide analogue is a cost-effective prophylaxis against hepatitis B virus after liver transplantation.
Topics: Adenine; Adult; Aged; Antiviral Agents; Cost-Benefit Analysis; Drug Costs; Female; Graft Survival; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Humans; Immunoglobulins; Liver Transplantation; Male; Middle Aged; Organophosphonates; Retrospective Studies; Tenofovir; Treatment Outcome; United States | 2015 |
Is zidovudine first-line therapy virologically comparable to tenofovir in resource-limited settings?
Topics: Adenine; Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Cross-Sectional Studies; Cyclopropanes; Female; Health Resources; HIV; HIV Infections; Humans; Lamivudine; Lesotho; Logistic Models; Male; Middle Aged; Organophosphonates; Tenofovir; Viral Load; Zidovudine | 2015 |
Painless penile papule.
Topics: Adenine; Adult; Anti-Bacterial Agents; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Biopsy; CD4 Lymphocyte Count; Coinfection; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Male; Nevirapine; Organophosphonates; Penicillin G Benzathine; Penis; Syphilis, Cutaneous; Tenofovir; Treatment Outcome | 2015 |
Natural Killer Cell Characteristics in Patients With Chronic Hepatitis B Virus (HBV) Infection Are Associated With HBV Surface Antigen Clearance After Combination Treatment With Pegylated Interferon Alfa-2a and Adefovir.
Topics: Adenine; Adult; Aged; Antigens, Surface; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Killer Cells, Natural; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Treatment Outcome; Young Adult | 2015 |
Synthesis, conformational studies, and biological properties of phosphonomethoxyethyl derivatives of nucleobases with a locked conformation via a pyrrolidine ring.
Topics: Adenine; Animals; Antimalarials; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hypoxanthine; Kinetics; Magnetic Resonance Spectroscopy; Organophosphonates; Oxygen; Pentosyltransferases; Plasmodium falciparum; Protein Conformation; Pyrrolidines; Structure-Activity Relationship | 2015 |
Relationship Between Serum DNA Replication, Clinicopathological Characteristics and Prognosis of Hepatitis B Virus-associated Glomerulonephritis with Severe Proteinuria by Lamivudine Plus Adefovir Dipivoxil Combination Therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA Replication; DNA, Viral; Drug Therapy, Combination; Female; Glomerulonephritis; Hepatitis B; Hepatitis B virus; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prognosis; Proteinuria; Young Adult | 2015 |
Low-dose adefovir dipivoxil may induce Fanconi syndrome: clinical characteristics and long-term follow-up for Chinese patients.
Topics: Adenine; Adult; Alkaline Phosphatase; Antiviral Agents; Asian People; Bone Density; Creatinine; Drug Administration Schedule; Fanconi Syndrome; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Phosphates; Retrospective Studies | 2015 |
A quantitative multiplex nuclease protection assay reveals immunotoxicity gene expression profiles in the rabbit model for vaginal drug safety evaluation.
Topics: Adenine; Animals; Anti-HIV Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation, Preclinical; Evaluation Studies as Topic; Female; Host-Pathogen Interactions; Immunohistochemistry; Inflammation; Interleukin-1beta; Interleukin-8; Mucous Membrane; Nonoxynol; Nuclease Protection Assays; Oligopeptides; Organophosphonates; Rabbits; Tenofovir; Toll-Like Receptor 4; Transcriptome; Vagina | 2015 |
Efficacy of tenofovir switch therapy for nucleos(t)ide-experienced patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Treatment Outcome | 2015 |
[Tenofovir rescue therapy for chronic hepatitis B patients after multiple treatment failures].
Topics: Adenine; Hepatitis B, Chronic; Humans; Organophosphonates; Tenofovir; Treatment Failure | 2015 |
Early kidney injury during long-term adefovir dipivoxil therapy for chronic hepatitis B.
Topics: Acute Kidney Injury; Adenine; Adult; Antiviral Agents; beta 2-Microglobulin; Biomarkers; Case-Control Studies; Creatinine; Drug Substitution; Female; Glomerular Filtration Rate; Guanine; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Predictive Value of Tests; Prospective Studies; Retinol-Binding Proteins; Risk Factors; Time Factors; Treatment Outcome | 2015 |
Triple combination of carbosilane dendrimers, tenofovir and maraviroc as potential microbicide to prevent HIV-1 sexual transmission.
Topics: Adenine; Animals; Anti-HIV Agents; Anti-Infective Agents; Antiviral Agents; Cell Survival; Cyclohexanes; Dendrimers; Drug Combinations; Female; HIV Infections; HIV-1; Humans; Maraviroc; Mice; Mice, Inbred BALB C; Mucous Membrane; Organophosphonates; Silanes; Software; Tenofovir; Triazoles; Vagina | 2015 |
Clonal evolution of multidrug resistant hepatitis B virus during entecavir rescue therapy.
Topics: Adenine; Adult; Antiviral Agents; Clonal Evolution; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load | 2015 |
Vaginal deployment and tenofovir delivery by microbicide gels.
Topics: Adenine; Algorithms; Anti-HIV Agents; Biotransformation; Computational Biology; Convection; Diffusion; Drug Compounding; Female; Gels; Humans; Models, Biological; Mucous Membrane; Organophosphonates; Pharmaceutical Vehicles; Phosphorylation; Tenofovir; Tissue Distribution; Vagina; Vaginal Absorption; Vaginal Creams, Foams, and Jellies; Viscosity | 2015 |
Impact of nucleos(t)ide analogue combination therapy on the estimated glomerular filtration rate in patients with chronic hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Nucleosides; Nucleotides; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine | 2015 |
Infectious disease. Combating emerging viral threats.
Topics: Adenine; Adenosine; Antiviral Agents; Benzamides; Chloroquine; Communicable Diseases, Emerging; Cyclosporins; Cytosine; Dengue; Drug Approval; Drug Design; Erlotinib Hydrochloride; Hemorrhagic Fever, Ebola; Humans; Imatinib Mesylate; Indoles; Organophosphonates; Piperazines; Purine Nucleosides; Pyrimidines; Pyrroles; Pyrrolidines; Quinazolines; Sunitinib; Viruses | 2015 |
Tenofovir alafenamide for HIV infection: is less more?
Topics: Adenine; Alanine; Anti-HIV Agents; Carbamates; Cobicistat; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Male; Organophosphonates; Quinolones; Tenofovir; Thiazoles | 2015 |
The expression of TLR-9, CD86, and CD95 phenotypes in circulating B cells of patients with chronic viral hepatitis B or C before and after antiviral therapy.
Topics: Adenine; Adult; Aged; Antibodies, Monoclonal; Antiviral Agents; B-Lymphocytes; B7-2 Antigen; DNA, Viral; fas Receptor; Female; Flow Cytometry; Genotype; Hepatitis B, Chronic; Hepatitis C, Chronic; Homeostasis; Humans; Immunoglobulin D; Leukocytes, Mononuclear; Male; Middle Aged; Oligodeoxyribonucleotides; Organophosphonates; Phenotype; Prevalence; Toll-Like Receptor 9; Viral Load; Young Adult | 2015 |
A case of entecavir resistance which is developed after complete viral suppression during entecavir treatment for nucleoside-naive chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Nucleosides; Organophosphonates; Remission Induction; Tenofovir | 2014 |
Response to potent anti-HBV agents in chronic hepatitis B and combined effect of HBV reverse transcriptase mutations.
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Tenofovir | 2015 |
Entecavir Combined With Adefovir Ameliorates Patients With Chronic Hepatitis B Who Fail to Respond to Nucleotide (Acid) Analog Monotherapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome | 2017 |
Preexposure prophylaxis for HIV infection.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Pre-Exposure Prophylaxis | 2015 |
Pre-exposure prophylaxis works--it's time to deliver.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Health Services Accessibility; HIV Infections; Humans; Organophosphonates; Pre-Exposure Prophylaxis; Tenofovir | 2015 |
Nucleoside-Nucleotide Analog Combination Therapy Is Effective in Preventing Recurrent Hepatitis B After Liver Transplantation.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Immunoglobulins; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Prospective Studies; Recurrence; Tenofovir | 2015 |
Tenofovir-based rescue therapy in chronic hepatitis B patients with suboptimal responses to adefovir with prior lamivudine resistance.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Republic of Korea; Retrospective Studies; Tenofovir; Time Factors; Young Adult | 2015 |
Infectious disease: New HIV-1 prodrug shows promise in phase III trials.
Topics: Adenine; Anti-HIV Agents; Carbamates; Deoxycytidine; Female; HIV Infections; Humans; Male; Organophosphonates; Quinolones; Thiazoles | 2015 |
Efficacy of Tenofovir-based Rescue Therapy in Lamivudine-resistant Chronic Hepatitis B Patients With Failure of Lamivudine and Adefovir Combination.
Topics: Adenine; Adult; Aged; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retreatment; Tenofovir; Time Factors; Treatment Outcome | 2015 |
Tenofovir-based rescue therapy for chronic hepatitis B patients who had failed treatment with lamivudine, adefovir, and entecavir.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Tenofovir; Treatment Failure | 2015 |
Remission of splenic marginal zone lymphoma in a patient treated for hepatitis B: a case of HBV-associated lymphoma.
Topics: Adenine; Bone Marrow; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunohistochemistry; Lymphoma, B-Cell, Marginal Zone; Male; Middle Aged; Organophosphonates; Remission Induction; Splenic Neoplasms; Tenofovir; Viral Load | 2015 |
HIV-serodiscordant couples desiring a child: 'treatment as prevention,' preexposure prophylaxis, or medically assisted procreation?
Topics: Adenine; Anti-HIV Agents; Cost-Benefit Analysis; Deoxycytidine; Emtricitabine; Female; Fertile Period; France; Health Care Costs; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Insemination, Artificial; Male; Models, Economic; Organophosphonates; Pre-Exposure Prophylaxis; Pregnancy; Reproductive Techniques, Assisted; Semen; Tenofovir | 2015 |
A novel baseline hepatitis B virus sequencing-based strategy for predicting adefovir antiviral response.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Male; Organophosphonates; Reproducibility of Results; ROC Curve; Sequence Analysis, DNA; Treatment Outcome; Viral Load; Young Adult | 2015 |
Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues.
Topics: Acrylamides; Adenine; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Cell Survival; Cycloaddition Reaction; Cytomegalovirus; Cytostatic Agents; Drug Design; Enterovirus; Humans; Isoxazoles; Naphthalimides; Nitrogen Oxides; Organophosphonates; Phlebovirus; Simplexvirus; Structure-Activity Relationship; Vaccinia virus | 2015 |
Synthesis and in vitro antiviral activities of [(dihydrofuran-2-yl)oxy]methyl-phosphonate nucleosides with 2-substituted adenine as base.
Topics: Adenine; Antiviral Agents; Diarrhea Viruses, Bovine Viral; Dose-Response Relationship, Drug; Hepatitis B virus; HIV; Microbial Sensitivity Tests; Molecular Structure; Organophosphonates; Purine Nucleosides | 2015 |
Prevalence and types of drug-resistant variants in Chinese patients with acute hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Female; Genetic Variation; Guanine; Hepatitis B; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation, Missense; Organophosphonates; Prevalence; RNA-Directed DNA Polymerase; Telbivudine; Thymidine; Time Factors; Young Adult | 2015 |
Identification, synthesis and characterization of new impurities in tenofovir.
Topics: Adenine; Drug Contamination; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mass Spectrometry; Organophosphonates; Organophosphorus Compounds; Quality Control; Reverse Transcriptase Inhibitors; Tenofovir | 2015 |
Increased occurrence of mutant rtI233V of HBV in patients receiving adefovir therapy.
Topics: Adenine; Adolescent; Adult; Aged; Amino Acid Substitution; Antiviral Agents; Child; Codon; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B; Hepatitis B virus; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Mutation; Organophosphonates; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Sequence Analysis, DNA; Virus Replication; Young Adult | 2016 |
Many in VOICE trial didn't use provided prevention products.
Topics: Adenine; Africa South of the Sahara; Anti-Retroviral Agents; Female; Gels; HIV Infections; Humans; Medication Adherence; Organophosphonates; Randomized Controlled Trials as Topic; Reverse Transcriptase Inhibitors; Tenofovir | 2015 |
Tenofovir for Hepatitis Delta.
Topics: Adenine; Hepatitis B; Hepatitis D; Humans; Male; Organophosphonates; Reverse Transcriptase Inhibitors | 2016 |
The long-term benefits of nucleos(t)ide analogs in compensated HBV cirrhotic patients with no or small esophageal varices: A 12-year prospective cohort study.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Dose-Response Relationship, Drug; Elasticity Imaging Techniques; Endoscopy, Gastrointestinal; Esophageal and Gastric Varices; Female; Follow-Up Studies; Forecasting; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Italy; Lamivudine; Liver; Liver Cirrhosis; Male; Middle Aged; Nucleosides; Organophosphonates; Prospective Studies; Reverse Transcriptase Inhibitors; Survival Rate; Tenofovir | 2015 |
Initial combination anti-viral therapy with lamivudine and adefovir dipivoxil decreases short-term fatality rate of hepatitis-B-virus-related acute-on-chronic liver failure.
Topics: Acute-On-Chronic Liver Failure; Adenine; Adolescent; Adult; Aged; Antiviral Agents; Female; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prognosis; Retrospective Studies; Survival Analysis; Treatment Outcome; Young Adult | 2015 |
Deep sequencing analysis of HBV genotype shift and correlation with antiviral efficiency during adefovir dipivoxil therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Genotype; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Male; Middle Aged; Organophosphonates; Sequence Analysis, DNA; Young Adult | 2015 |
[Efficacy and safety of telbivudine alone and combined with adefovir for the treatment of nucleos(t)ide-naive chronic hepatitis B in patients with high-level hepatitis B virus load].
Topics: Adenine; Alanine Transaminase; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome; Viral Load | 2015 |
Osteomalacia as a Cause of Chronic Low Back and Buttock Pain.
Topics: Adenine; Adult; Antiviral Agents; Buttocks; Fractures, Spontaneous; Gait; Humans; Hypophosphatemia; Low Back Pain; Magnetic Resonance Imaging; Male; Organophosphonates; Osteomalacia; Ribs; Sacrum | 2015 |
Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis.
Topics: Adenine; Adenylate Cyclase Toxin; Animals; Binding Sites; Bordetella pertussis; Cell Line; Cell Survival; Drug Screening Assays, Antitumor; Half-Life; Humans; Male; Mice; Molecular Docking Simulation; Organophosphonates; Prodrugs; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Rats; Rats, Wistar | 2015 |
Comparison of entecavir monotherapy and de novo lamivudine and adefovir combination therapy in HBeAg-positive chronic hepatitis B with high viral load: 48-week result.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Blood; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Prospective Studies; Treatment Outcome; Viral Load; Young Adult | 2016 |
Early Initiation of Antiretroviral Therapy Can Functionally Control Productive HIV-1 Infection in Humanized-BLT Mice.
Topics: Adenine; Animals; Anti-HIV Agents; Antigens, CD34; Bone Marrow; CD8-Positive T-Lymphocytes; Disease Models, Animal; Disease Progression; DNA, Viral; Gene Dosage; HIV Infections; HIV-1; Humans; Liver; Mice; Mice, Inbred NOD; Mice, Transgenic; Organophosphonates; Pilot Projects; RNA, Viral; Spleen; Tenofovir; Thymus Gland; Viral Load; Virus Replication | 2015 |
Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives.
Topics: Adenine; Antiviral Agents; Drug Design; Guanine; Hep G2 Cells; Hepatitis B virus; Humans; In Vitro Techniques; Organophosphonates | 2015 |
Outcome of adefovir add-on lamivudine rescue therapy of up to 5 years in patients with lamivudine-resistant chronic hepatitis B.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Multivariate Analysis; Organophosphonates; ROC Curve; Time Factors; Treatment Outcome | 2016 |
VOICE reveals the need to improve adherence in PrEP trials.
Topics: Adenine; Anti-Retroviral Agents; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Organophosphonates; Pre-Exposure Prophylaxis | 2015 |
Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.
Topics: Adenine; Amino Acid Substitution; Antiviral Agents; Arabinofuranosyluracil; Cell Line, Tumor; Drug Resistance, Multiple, Viral; Gene Products, pol; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microbial Sensitivity Tests; Models, Molecular; Organophosphonates; Tenofovir; Virus Replication | 2015 |
Mechanism of Adefovir, Tenofovir and Entecavir Resistance: Molecular Modeling Studies of How A Novel Anti-HBV Agent (FMCA) Can Overcome the Drug Resistance.
Topics: Adenine; Adenosine; Amino Acid Sequence; Antiviral Agents; Binding Sites; Catalytic Domain; Databases, Protein; Drug Resistance, Viral; Gene Products, pol; Guanine; Hepatitis B; Hepatitis B virus; HIV Reverse Transcriptase; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Molecular Sequence Data; Mutation; Organophosphonates; Sequence Alignment; Tenofovir | 2015 |
Adefovir- or Lamivudine-Induced Renal Tubular Dysfunction after Liver Transplantation.
Topics: Adenine; Female; Hepatitis B; Humans; Incidence; Kidney Diseases; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Postoperative Complications; Recurrence; Republic of Korea; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Factors | 2015 |
[Clinical analysis of Fanconi syndrome induced by adefovir dipivoxil].
Topics: Adenine; Fanconi Syndrome; Humans; Organophosphonates | 2015 |
Long-term follow-up of HBsAg-positive patients in Germany.
Topics: Adenine; Adult; Age Factors; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Germany; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Male; Mass Screening; Middle Aged; Organophosphonates; Prognosis; Prospective Studies; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Time Factors; Turkey | 2016 |
[Adefovir dipivoxil effects on and related factors of blood phosphorus metabolism in patients with chronic hepatitis B].
Topics: Adenine; Aged; Antiviral Agents; Creatinine; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Interferons; Lamivudine; Male; Organophosphonates; Phosphorus | 2015 |
Mechanism study on stability enhancement of adefovir dipivoxil by cocrystallization: Degradation kinetics and structure-stability correlation.
Topics: Adenine; Crystallization; Crystallography, X-Ray; Drug Stability; Hydrogen Bonding; Hydrolysis; Kinetics; Maleates; Organophosphonates; Powder Diffraction; Prodrugs; Salicylates; Water; X-Ray Diffraction | 2016 |
Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Viral Load; Young Adult | 2015 |
Effects of 1α,25-Dihydroxyvitamin D3 on Intestinal Absorption and Disposition of Adefovir Dipivoxil and Its Metabolite, Adefovir, in Rats.
Topics: Adenine; Administration, Oral; Animals; Area Under Curve; Biological Availability; Calcitriol; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Multidrug Resistance-Associated Proteins; Organophosphonates; Rats, Sprague-Dawley; Tissue Distribution | 2015 |
Entecavir plus tenofovir versus entecavir plus adefovir in chronic hepatitis B patients with a suboptimal response to lamivudine and adefovir combination therapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Odds Ratio; Organophosphonates; Real-Time Polymerase Chain Reaction; Retrospective Studies; Tenofovir; Viral Load | 2015 |
Tenofovir Gel to Prevent HSV-2 Infection.
Topics: Adenine; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2015 |
Tenofovir Gel to Prevent HSV-2 Infection.
Topics: Adenine; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2015 |
Tenofovir Gel to Prevent HSV-2 Infection.
Topics: Adenine; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2015 |
Comprehensive analysis of hospital-based prospective cohort reveals the unique effectiveness and safety for nucleos(t)ide analogues in HBV patients.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Hospitalization; Humans; Lamivudine; Male; Organophosphonates; Prospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2016 |
Epidemiology study of HBV genotypes and antiviral drug resistance in multi-ethnic regions from Western China.
Topics: Adenine; Adult; Antiviral Agents; China; DNA, Viral; Drug Resistance, Viral; Ethnicity; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Molecular Epidemiology; Mutation; Organophosphonates; Prevalence | 2015 |
Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Hospitals; Humans; Incidence; Kidney Diseases; Lamivudine; Male; Middle Aged; Nephrons; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Risk Factors; Telbivudine; Tenofovir; Thailand; Thymidine; Tropical Medicine | 2015 |
Development and Validation of a Sensitive LC-MS-MS Method for the Determination of Adefovir in Human Serum and Urine: Application to a Clinical Pharmacokinetic Study.
Topics: Adenine; Chromatography, High Pressure Liquid; Humans; Limit of Detection; Organophosphonates; Reproducibility of Results; Reverse Transcriptase Inhibitors; Tandem Mass Spectrometry | 2016 |
Pericoital application of tenofovir gel reduced risk for herpes simplex virus type 2 in HIV-negative women.
Topics: Adenine; Female; Herpes Genitalis; Herpesvirus 2, Human; Humans; Organophosphonates; Reverse Transcriptase Inhibitors | 2015 |
Rhabdomyolysis due to lamivudine re-administration in a patient with HBV-related hepatic failure caused by interruption of lamivudine and adefovir.
Topics: Adenine; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Liver Failure; Male; Medication Adherence; Middle Aged; Organophosphonates; Rhabdomyolysis | 2015 |
Synthesis and biological properties of prodrugs of (S)-3-(adenin-9-yl)-2-(phosphonomethoxy)propanoic acid.
Topics: Adenine; Antiviral Agents; Dose-Response Relationship, Drug; Hepacivirus; Microbial Sensitivity Tests; Molecular Structure; Organophosphonates; Prodrugs; Structure-Activity Relationship | 2016 |
Variability in long-term hepatitis B virus dynamics under antiviral therapy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Female; Follow-Up Studies; Hepatitis B; Hepatitis B virus; Humans; Interferon-alpha; Liver; Male; Models, Biological; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Viremia | 2016 |
[Efficacy of combination antiviral therapy following childbirth in pregnant HBV carriers receiving telbivudine for prevention of mother-to-child transmission].
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Carrier State; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Infectious Disease Transmission, Vertical; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Trimester, Third; Recombinant Proteins; Telbivudine; Thymidine | 2015 |
A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity.
Topics: 3T3 Cells; Adenine; Animals; Antiviral Agents; Cell Line; Cell Line, Transformed; Cell Survival; Cidofovir; Cytosine; Dose-Response Relationship, Drug; Forecasting; Gene Expression Regulation; HEK293 Cells; Humans; Kidney Tubules, Proximal; Mice; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates | 2016 |
Preventing long-term tenofovir renal toxicity by pharmacokinetic assessment.
Topics: Adenine; Anti-HIV Agents; HIV Infections; Humans; Organophosphonates; Tenofovir | 2016 |
Off-treatment efficacy of 3-year nucleos(t)ide analogues in chronic hepatitis B patients.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2016 |
In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection.
Topics: Adenine; Case-Control Studies; DNA Probes; DNA, Viral; Hep G2 Cells; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; In Situ Hybridization; Liver; Organophosphonates; RNA, Viral; Sensitivity and Specificity; Virus Replication | 2016 |
Application of ionic liquid to polymorphic transformation of anti-viral/HIV drug adefovir dipivoxil.
Topics: Adenine; Anti-HIV Agents; Crystallization; Drug Stability; Ionic Liquids; Models, Theoretical; Organophosphonates; Phase Transition; Solubility; Solutions; Spectroscopy, Fourier Transform Infrared; Transition Temperature | 2016 |
[Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Polymerase Chain Reaction; Telbivudine; Tenofovir; Thymidine | 2016 |
Profile of HBV polymerase gene mutations during entecavir treatment in patients with chronic hepatitis B.
Topics: Adenine; Adolescent; Adult; Alanine Transaminase; Antiviral Agents; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Viral Load; Young Adult | 2016 |
Tenofovir tablet not effective in preventing HIV in women.
Topics: Adenine; Anti-HIV Agents; Female; HIV Infections; Humans; Organophosphonates; Tablets; Tenofovir | 2011 |
Resistance of ground glass hepatocytes to oral antivirals in chronic hepatitis B patients and implication for the development of hepatocellular carcinoma.
Topics: Adenine; Administration, Oral; Adolescent; Adult; Amino Acid Sequence; Antiviral Agents; Biopsy; Carcinoma, Hepatocellular; DNA, Circular; Drug Resistance, Viral; Fatty Liver; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Humans; Lamivudine; Liver; Liver Neoplasms; Male; Middle Aged; Necrosis; Organophosphonates; Protein Precursors; Sequence Deletion; Viral Load; Young Adult | 2016 |
[Tetracycline-inducible replications of wild-type and an adefovir-dipivoxil-resistant hepatitis B virus in human liver cells].
Topics: Adenine; Antiviral Agents; Cell Line; Drug Resistance, Viral; Genotype; Hepatitis B; Hepatitis B virus; Hepatocytes; Humans; Organophosphonates; Plasmids; Tetracyclines; Transfection; Virus Replication | 2016 |
Tenofovir alafenamide: safer, but questions remain.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; HIV Infections; HIV-1; Humans; Organophosphonates; Tenofovir | 2016 |
Cost-effectiveness comparison of lamivudine plus adefovir combination treatment and nucleos(t)ide analog monotherapies in Chinese chronic hepatitis B patients.
Topics: Adenine; Adult; Cost-Benefit Analysis; Drug Therapy, Combination; Hepatitis B, Chronic; Humans; Lamivudine; Nucleosides; Organophosphonates | 2016 |
De novo entecavir+adefovir dipivoxil+lamivudine triple-resistance mutations resulting from sequential therapy with adefovir dipivoxil, and lamivudine.
Topics: Adenine; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Viral Proteins | 2016 |
Compartmental approach to assess bioequivalence compared to the noncompartmental approach.
Topics: Adenine; Finasteride; Humans; Monte Carlo Method; Organophosphonates; Therapeutic Equivalency; Tyrosine | 2016 |
Hepatitis B virus related cryoglobulinemic vasculitis: A multicentre open label study from the Gruppo Italiano di Studio delle Crioglobulinemie - GISC.
Topics: Adenine; Aged; Antiviral Agents; Cryoglobulinemia; Female; Guanine; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Italy; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome; Vasculitis | 2016 |
Intrahepatic IP-10 mRNA and plasma IP-10 levels as response marker for HBeAg-positive chronic hepatitis B patients treated with peginterferon and adefovir.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biomarkers; Biopsy; Chemokine CXCL10; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Liver; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Prospective Studies; Recombinant Proteins; RNA, Messenger; Treatment Outcome | 2016 |
Cost-Effectiveness of Peg-Interferon, Interferon and Oral Nucleoside Analogues in the Treatment of Chronic Hepatitis B and D Infections in China.
Topics: Adenine; Adult; Age Factors; Aged; Antiviral Agents; China; Cohort Studies; Cost of Illness; Cost-Benefit Analysis; Drug Costs; Female; Hepatitis B, Chronic; Hepatitis D, Chronic; Humans; Interferons; Male; Markov Chains; Middle Aged; Nucleosides; Organophosphonates; Palliative Care; Quality-Adjusted Life Years | 2016 |
First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi's syndrome.
Topics: Absorptiometry, Photon; Adenine; Alanine; Coinfection; Dose-Response Relationship, Drug; Fanconi Syndrome; Hepatitis B, Chronic; HIV Infections; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Outcome | 2016 |
Pathologic Femoral Neck Fracture Due to Fanconi Syndrome Induced by Adefovir Dipivoxil Therapy for Hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Fanconi Syndrome; Femoral Neck Fractures; Fractures, Spontaneous; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Osteomalacia | 2016 |
Cost-effectiveness analysis of tenofovir disoproxil fumarate for treatment of chronic hepatitis B in China.
Topics: Adenine; Antiviral Agents; Cost-Benefit Analysis; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Markov Chains; Organophosphonates; Quality-Adjusted Life Years; Telbivudine; Tenofovir; Thymidine; Treatment Outcome | 2016 |
Impact of FIB-4 index on hepatocellular carcinoma incidence during nucleos(t)ide analogue therapy in patients with chronic hepatitis B: An analysis using time-dependent receiver operating characteristic.
Topics: Adenine; Alanine Transaminase; Antiviral Agents; Aspartate Aminotransferases; Biomarkers; Carcinoma, Hepatocellular; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Incidence; Lamivudine; Liver Neoplasms; Male; Middle Aged; Multivariate Analysis; Organophosphonates; Phosphorous Acids; Platelet Count; Proportional Hazards Models; Risk Factors; ROC Curve; Time Factors | 2017 |
Urinary β-2 Microglobulin Levels Sensitively Altered in an Osteomalacia Patient Receiving Add-on Adefovir Dipivoxil Therapy for Hepatitis B Virus Infection.
Topics: Adenine; Aged; Antiviral Agents; beta 2-Microglobulin; Female; Hepatitis B, Chronic; Humans; Japan; Organophosphonates; Osteomalacia | 2016 |
The efficacy of tenofovir-based therapy in patients showing suboptimal response to entecavir-adefovir combination therapy.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Republic of Korea; Retrospective Studies; Tenofovir; Treatment Outcome | 2016 |
Durability of the virological response after lamivudine discontinuation in lamivudine-resistant patients with a complete virological response after lamivudine and adefovir combination therapy.
Topics: Adenine; Adult; Aged; Anti-HIV Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Recurrence; Sustained Virologic Response; Time Factors; Withholding Treatment | 2017 |
A five years study of antiviral effect of entecavir in Chinese chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; Asian People; China; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Time Factors; Treatment Outcome; Viral Load | 2016 |
Is the tenofovir based therapy almighty for previous treatment failure in chronic hepatitis B?
Topics: Adenine; Antiviral Agents; DNA, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Tenofovir; Treatment Failure; Treatment Outcome | 2016 |
Effect of nonalcoholic steatohepatitis on renal filtration and secretion of adefovir.
Topics: Adenine; Animals; Choline; Diet; Glomerular Filtration Rate; Kidney; Male; Methionine; Non-alcoholic Fatty Liver Disease; Organophosphonates; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors | 2016 |
The long-term efficacy of combining nucleos(t)ide analog and low-dose hepatitis B immunoglobulin on post-transplant hepatitis B virus recurrence.
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Immunoglobulins; Immunologic Factors; Kaplan-Meier Estimate; Lamivudine; Liver Transplantation; Male; Middle Aged; Organophosphonates; Postoperative Complications; Proportional Hazards Models; Recurrence; Retrospective Studies; Tenofovir; Treatment Outcome | 2016 |
Nucleos(t)ide analog(s) prophylaxis after hepatitis B immunoglobulin withdrawal against hepatitis B and D recurrence after liver transplantation.
Topics: Adenine; Adult; Antiviral Agents; Coinfection; DNA, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis D, Chronic; Humans; Immunoglobulins; Lamivudine; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Organophosphonates; Secondary Prevention; Tenofovir; Treatment Outcome; Withholding Treatment; Young Adult | 2016 |
[HBsAg clearance rate in patients with HBeAg-positive chronic hepatitis B: a comparative effect analysis based on the real world].
Topics: Adenine; Antiviral Agents; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Lamivudine; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2016 |
Management of Clevudine-Resistant Chronic Hepatitis B: A Multicenter Cohort Study.
Topics: Adenine; Adult; Aged; Antiviral Agents; Arabinofuranosyluracil; Cohort Studies; Disease Management; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Viral Load | 2017 |
Real-World Experiences with Tenofovir Disoproxil Fumarate: Is this the "B-Ticket"?
Topics: Adenine; HIV Infections; Humans; Organophosphonates; Tenofovir | 2016 |
Pre-existing mutations related to tenofovir in chronic hepatitis B patients with long-term nucleos(t)ide analogue drugs treatment by ultra-deep pyrosequencing.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Multiple; Female; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; Sequence Analysis, DNA; Tenofovir | 2016 |
Reduction of covalently closed circular DNA with long-term nucleos(t)ide analogue treatment in chronic hepatitis B.
Topics: Adenine; Antiviral Agents; Biopsy; DNA, Circular; DNA, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Liver; Male; Middle Aged; Nucleosides; Organophosphonates; Outcome Assessment, Health Care; Telbivudine; Thymidine; Time; Virus Replication | 2017 |
Immune reconstitution inflammatory syndrome associated with dermatophytoses in two HIV-1 positive patients in rural Tanzania: a case report.
Topics: Adenine; Adult; Africa; Alkynes; Antiretroviral Therapy, Highly Active; Benzoxazines; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cyclopropanes; Deoxycytidine; Female; HIV Infections; HIV-1; Humans; Immune Reconstitution Inflammatory Syndrome; Male; Organophosphonates; Tanzania; Tinea | 2016 |
Lamivudine/Adefovir Treatment Increases the Rate of Spontaneous Mutation of Hepatitis B Virus in Patients.
Topics: Adenine; Drug Resistance, Viral; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunosuppressive Agents; Lamivudine; Male; Mutation; Organophosphonates; Polymorphism, Single Nucleotide | 2016 |
No detectable resistance to tenofovir disoproxil fumarate in HBeAg+ and HBeAg- patients with chronic hepatitis B after 8 years of treatment.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; Sequence Analysis, DNA; Tenofovir | 2017 |
Osteomalacia induced by long-term low-dose adefovir dipivoxil: Clinical characteristics and genetic predictors.
Topics: Adenine; Amino Acid Sequence; Case-Control Studies; DNA Mutational Analysis; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transport Protein 1; Organophosphonates; Osteomalacia; Polymorphism, Single Nucleotide; Risk Factors; Sequence Homology, Amino Acid | 2016 |
The Effect of Prophylactic Lamivudine plus Adefovir Therapy Compared with Lamivudine Alone in Preventing Hepatitis B Reactivation in Lymphoma Patients with High Baseline HBV DNA during Chemotherapy.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Child; DNA, Viral; Drug Interactions; Female; Hepatitis B virus; Humans; Lamivudine; Lymphoma; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk; Virus Activation; Young Adult | 2016 |
Comparison of the clinical outcomes between antiviral-naïve patients treated with entecavir and lamivudine-resistant patients receiving adefovir add-on lamivudine combination treatment.
Topics: Adenine; Adult; Alanine Transaminase; Antibodies, Viral; Antiviral Agents; Disease Progression; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Genotype; Guanine; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Treatment Outcome | 2016 |
Reactions and Receptivity to Framing HIV Prevention Message Concepts About Pre-Exposure Prophylaxis for Black and Latino Men Who Have Sex with Men in Three Urban US Cities.
Topics: Adenine; Adult; Anti-HIV Agents; Black or African American; Black People; Chicago; Cities; Condoms; Deoxycytidine; Emtricitabine; Female; Focus Groups; Health Knowledge, Attitudes, Practice; Hispanic or Latino; HIV Infections; Homosexuality, Male; Humans; Male; Organophosphonates; Patient Acceptance of Health Care; Pre-Exposure Prophylaxis; Qualitative Research; Safe Sex; Tenofovir; United States; Urban Population | 2016 |
Synthesis and evaluation of novel amonafide-polyamine conjugates as anticancer agents.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Microscopy, Fluorescence; Naphthalimides; Neoplasms; Organophosphonates; Polyamines; Transplantation, Heterologous | 2017 |
Identification of a new hepatitis B virus recombinant D2/D3 in the city of São Paulo, Brazil.
Topics: Adenine; Adult; Aged; Antiviral Agents; Brazil; Drug Resistance, Viral; Female; Genotype; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Lamivudine; Male; Middle Aged; Molecular Epidemiology; Mutation; Organophosphonates; Phylogeny; Reassortant Viruses; Recombination, Genetic; Retrospective Studies | 2017 |
Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Asymptomatic Infections; Carcinoma, Hepatocellular; Culture Media, Conditioned; DNA, Viral; Female; Gene Expression; Genotype; Guanine; Hep G2 Cells; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; HT29 Cells; Humans; Interferons; Interleukins; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Polymorphism, Genetic; Recombinant Proteins; Tenofovir; Up-Regulation; Young Adult | 2018 |
Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates.
Topics: Adenine; Antiviral Agents; Cell Line; Cell Proliferation; Cytostatic Agents; HeLa Cells; Herpesvirus 3, Human; Humans; Inhibitory Concentration 50; Molecular Structure; Naphthalimides; Organophosphonates | 2016 |
Comparison of Detection Rate and Mutational Pattern of Drug-Resistant Mutations Between a Large Cohort of Genotype B and Genotype C Hepatitis B Virus-Infected Patients in North China.
Topics: Adenine; Adult; Antiviral Agents; China; Cohort Studies; Drug Resistance, Multiple, Viral; Female; Gene Expression; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Microbial Sensitivity Tests; Middle Aged; Mutation Rate; Organophosphonates; Phylogeny; Viral Proteins | 2017 |
Comparison of the Efficacies and Safety of Combined Therapy between Telbivudine Plus Adefovir and Lamivudine Plus Adefovir in Patients with Hepatitis B Virus Infection in Real-World Practice.
Topics: Adenine; Adult; Biomarkers; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Treatment Outcome | 2016 |
Circulating kidney injury molecule-1 is a novel diagnostic biomarker for renal dysfunction during long-term adefovir therapy in chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; Cohort Studies; Female; Hepatitis A Virus Cellular Receptor 1; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Renal Insufficiency, Chronic; Retrospective Studies | 2016 |
Relationship between hepatitis B virus reverse transcriptase 181 mutation and S gene mutation in hepatitis B virus chronically infected patients.
Topics: Adenine; Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Young Adult | 2016 |
DNMT1 modulation in chronic hepatitis B patients and hypothetic influence on mitochondrial DNA methylation status during long-term nucleo(t)side analogs therapy.
Topics: Adenine; Aged; Antiviral Agents; Cross-Sectional Studies; Cytosine; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; DNA, Mitochondrial; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Leukocytes, Mononuclear; Male; Middle Aged; Nucleosides; Organophosphonates; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Telbivudine; Thymidine | 2017 |
A novel pretreatment method combining sealing technique with direct injection technique applied for improving biosafety.
Topics: Adenine; Antiviral Agents; Chromatography, High Pressure Liquid; Clinical Laboratory Techniques; Humans; Limit of Detection; Organophosphonates; Tenofovir; Ultrafiltration; Virus Diseases | 2017 |
Tenofovir disoproxil fumarate monotherapy maintains HBV suppression achieved by a "de novo" combination of lamivudine-adefovir: a pilot study.
Topics: Adenine; Adolescent; Adult; Antiviral Agents; Drug Resistance, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Italy; Lamivudine; Male; Middle Aged; Organophosphonates; Pilot Projects; Tenofovir; Treatment Outcome; Viral Load | 2016 |
Switch to tenofovir-based therapy or to continue adefovir-based therapy in CHB patients with suboptimal response to adefovir-based combination?
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Tenofovir | 2016 |
Comparative evaluation of long-term monotherapies & combination therapies in patients with chronic hepatitis B: A pilot study.
Topics: Adenine; Adult; Drug Combinations; Drug Resistance, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Pilot Projects; Tenofovir | 2016 |
Comment on: Efficacy of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate as treatment for primary or recent HIV infection.
Topics: Adenine; Anti-HIV Agents; Cobicistat; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Organophosphonates; Quinolones; Tenofovir | 2017 |
Long-term efficacy and safety of switching from lamivudine+adefovir to tenofovir disoproxil fumarate in virologically suppressed patients.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Italy; Kaplan-Meier Estimate; Kidney Function Tests; Lamivudine; Male; Middle Aged; Organophosphonates; Tenofovir; Treatment Failure | 2017 |
Tenofovir has inferior efficacy in adefovir-experienced chronic hepatitis B patients compared to nucleos(t)ide-naïve patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Nucleotides; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Tenofovir; Treatment Outcome | 2017 |
Activity of Multidrug Resistance-Associated Proteins 1-5 (MRP1-5) in the RPMI 2650 Cell Line and Explants of Human Nasal Turbinate.
Topics: Adenine; Blotting, Western; Caco-2 Cells; Cell Line; Erythromycin; Humans; Immunohistochemistry; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Nasal Mucosa; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction; Turbinates | 2017 |
Evolutionary trends of resistance mutational patterns of HBV reverse transcriptase over years (2002-2012) of different treatment regimens: The legacy of lamivudine/adefovir combination treatment.
Topics: Adenine; Antiviral Agents; DNA Mutational Analysis; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Evolution, Molecular; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Mutation; Organophosphonates; Polymorphism, Genetic; RNA-Directed DNA Polymerase; Sequence Analysis; Tenofovir; Treatment Failure | 2017 |
Efficacy of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate as treatment for primary or recent HIV infection-authors' response.
Topics: Adenine; Anti-HIV Agents; Cobicistat; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Organophosphonates; Quinolones; Tenofovir | 2017 |
Tenofovir and adefovir down-regulate mitochondrial chaperone TRAP1 and succinate dehydrogenase subunit B to metabolically reprogram glucose metabolism and induce nephrotoxicity.
Topics: Adenine; Animals; Anti-HIV Agents; Cell Line; Cell Proliferation; Cell Survival; Glucose; Glycolysis; HSP90 Heat-Shock Proteins; Humans; Kidney Diseases; Mice; Mitochondria; Models, Biological; Organophosphonates; Proteome; Proteomics; Succinate Dehydrogenase; Tenofovir | 2017 |
A different inhibitor is required for overcoming entecavir resistance: a comparison of four rescue therapies in a retrospective study.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Practice Guidelines as Topic; Retrospective Studies; Tenofovir; Treatment Outcome; Viral Load | 2017 |
Preparation and characterization of adefovir dipivoxil-stearic acid cocrystal with enhanced physicochemical properties.
Topics: Adenine; Chemical Phenomena; Chemistry, Pharmaceutical; Microscopy, Electron, Scanning; Organophosphonates; Spectroscopy, Fourier Transform Infrared; Stearic Acids; X-Ray Diffraction | 2018 |
HBsAg loss after peginterferon-nucleotide combination treatment in chronic hepatitis B patients: 5 years of follow-up.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Follow-Up Studies; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Sustained Virologic Response; Treatment Outcome; Young Adult | 2017 |
Analysis of immunological mechanisms exerted by HBsAg-HBIG therapeutic vaccine combined with Adefovir in chronic hepatitis B patients.
Topics: Adenine; Adjuvants, Immunologic; Adult; Antigen-Antibody Complex; Combined Modality Therapy; Female; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B, Chronic; Humans; Interleukin-10; Interleukin-17; Interleukin-2; Male; Organophosphonates; Th1 Cells; Th2 Cells; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Young Adult | 2017 |
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Aspartic Acid; Cell Line; Cytomegalovirus; Drug Resistance, Viral; Drug Stability; Esters; Hepatitis B virus; Herpesvirus 3, Human; Humans; Hydrogen-Ion Concentration; Microsomes, Liver; Nucleosides; Organophosphonates; Prodrugs; Stereoisomerism; Structure-Activity Relationship | 2017 |
Overcoming the Hydrolytic Lability of a Reaction Intermediate in Production of Protein/Drug Conjugates: Conjugation of an Acyclic Nucleoside Phosphonate to a Model Carrier Protein.
Topics: Adenine; Chromatography, Ion Exchange; Chromatography, Liquid; Cidofovir; Cytosine; HIV; Nucleosides; Organophosphonates; Pharmaceutical Preparations; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tenofovir | 2017 |
Adefovir-Induced Hypophosphatemic Osteomalacia Mimicking Bone Metastases From Primary Hepatocarcinoma.
Topics: Adenine; Bone Neoplasms; Humans; Hypophosphatemia; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Osteomalacia; Single Photon Emission Computed Tomography Computed Tomography | 2017 |
Lactate serum concentrations during treatment with nucleos(t)ide analogues in hepatitis B with or without cirrhosis.
Topics: Acidosis, Lactic; Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Biomarkers; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lactic Acid; Lamivudine; Liver Cirrhosis; Male; Middle Aged; Organophosphonates; Prospective Studies; Risk Factors; Sex Factors; Tenofovir; Time Factors; Treatment Outcome; Up-Regulation; Young Adult | 2017 |
Viral minority variants in the core promoter and precore region identified by deep sequencing are associated with response to peginterferon and adefovir in HBeAg negative chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Genetic Variation; Genotype; Hepatitis B Surface Antigens; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Interferon-alpha; Male; Middle Aged; Mutation; Organophosphonates; Polyethylene Glycols; Promoter Regions, Genetic; Prospective Studies; Recombinant Proteins; Viral Load | 2017 |
Adefovir dipivoxil loaded proliposomal powders with improved hepatoprotective activity: formulation, optimization, pharmacokinetic, and biodistribution studies.
Topics: Adenine; Animals; Antiviral Agents; Biological Availability; Drug Carriers; Hepatitis B; Liposomes; Male; Organophosphonates; Powders; Rats, Wistar; Tissue Distribution | 2018 |
Nephrolithiasis and Osteomalacia associated with adefovir-induced Fanconi syndrome in a patient with hepatitis B.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B; Humans; Male; Middle Aged; Nephrolithiasis; Organophosphonates; Osteomalacia | 2017 |
Adefovir-induced Fanconi syndrome associated with osteomalacia.
Topics: Adenine; Adult; Bone and Bones; Fanconi Syndrome; Female; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Hepatitis B; Humans; Hypophosphatemia; Kidney Tubules, Proximal; Mitochondria; Organophosphonates; Osteomalacia | 2018 |
Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.
Topics: Adenine; Animals; Antigens, Bacterial; Aorta; Arterial Pressure; Arteries; Bacterial Toxins; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Organophosphonates; Phenylephrine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Shock; Vasoconstrictor Agents | 2017 |
Letter: lipid-lowering effect of tenofovir disoproxil fumarate in chronic hepatitis B-more evidence is needed. Authors' reply.
Topics: Adenine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lipids; Organophosphonates; Tenofovir | 2017 |
Letter: lipid-lowering effect of tenofovir disoproxil fumarate in chronic hepatitis B-more evidence is needed.
Topics: Adenine; Antiviral Agents; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Lipids; Organophosphonates; Tenofovir | 2017 |
The Female Genital Tract Microbiome Is Associated With Vaginal Antiretroviral Drug Concentrations in Human Immunodeficiency Virus-Infected Women on Antiretroviral Therapy.
Topics: Adenine; Adolescent; Adult; Anti-Retroviral Agents; Cohort Studies; Deoxycytidine; Emtricitabine; Female; Fumarates; Genitalia, Female; HIV Infections; Humans; Microbiota; Middle Aged; Organophosphonates; Prospective Studies; Tenofovir; Young Adult | 2017 |
Can We Trust Safety of Tenofovir Disoproxil in Patients with Decompensated Cirrhosis?
Topics: Adenine; Humans; Liver Cirrhosis; Organophosphonates; Tenofovir | 2017 |
Efficacy and safety of three adefovir-based combination therapies in HBeAg-positive chronic hepatitis B patients with suboptimal response to adefovir monotherapy.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Liver; Liver Function Tests; Male; Organophosphonates; Treatment Outcome; Viral Load | 2017 |
Effective viral suppression is necessary to reduce hepatocellular carcinoma development in cirrhotic patients with chronic hepatitis B: Results of a 10-year follow up.
Topics: Adenine; Adult; Antiviral Agents; Carcinoma, Hepatocellular; Female; Follow-Up Studies; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Kaplan-Meier Estimate; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Proportional Hazards Models; Prospective Studies; Risk Factors; Sustained Virologic Response; Time Factors; Treatment Outcome; Viral Load | 2017 |
Comparing Efficacy of Lamivudine, Adefovir Dipivoxil, Telbivudine, and Entecavir in Treating Nucleoside Analogues Naïve for HBeAg-Negative Hepatitis B with Medium Hepatitis B Virus (HBV) DNA Levels.
Topics: Adenine; Adult; Alanine Transaminase; DNA, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B e Antigens; Humans; Lamivudine; Male; Multivariate Analysis; Nucleosides; Organophosphonates; Proportional Hazards Models; Telbivudine; Thymidine | 2017 |
Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1).
Topics: Acyclovir; Adenine; Animals; Antiviral Agents; Apigenin; Cell Survival; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Herb-Drug Interactions; Inhibitory Concentration 50; Kidney Diseases; Madin Darby Canine Kidney Cells; Male; Organic Anion Transport Protein 1; Organophosphonates; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Time Factors | 2017 |
Direct Detection of Drug-Resistant Hepatitis B Virus in Serum Using a Dendron-Modified Microarray.
Topics: Adenine; Dendrimers; DNA, Viral; Drug Resistance, Viral; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Microarray Analysis; Mutation; Nucleic Acid Amplification Techniques; Organophosphonates; Reverse Transcriptase Polymerase Chain Reaction | 2018 |
Delivery of Amonafide from Fructose-Coated Nanodiamonds by Oxime Ligation for the Treatment of Human Breast Cancer.
Topics: Adenine; Breast Neoplasms; Coated Materials, Biocompatible; Drug Delivery Systems; Female; Fructose; Humans; MCF-7 Cells; Nanodiamonds; Naphthalimides; Organophosphonates | 2018 |
Lysosomes-targeting imaging and anticancer properties of novel bis-naphthalimide derivatives.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line, Tumor; DNA; Drug Screening Assays, Antitumor; Fluorescence; Fluorescent Dyes; Humans; Lysosomes; Microscopy, Confocal; Microscopy, Fluorescence; Naphthalimides; Nucleic Acid Conformation; Organophosphonates; Piperazines; Piperidines; S Phase Cell Cycle Checkpoints; Transition Temperature; Zebrafish | 2018 |
Clinical features of hypophosphatemic osteomalacia induced by long-term low-dose adefovir dipivoxil.
Topics: Adenine; Adult; Aged; Alkaline Phosphatase; Biomarkers; China; Cross-Sectional Studies; Drug Monitoring; Early Diagnosis; Female; Glomerular Filtration Rate; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Phosphorus; Predictive Value of Tests; Retrospective Studies; Reverse Transcriptase Inhibitors; Risk Factors; Time Factors | 2018 |
Validation and implementation of liquid chromatographic-mass spectrometric (LC-MS) methods for the quantification of tenofovir prodrugs.
Topics: Adenine; Alanine; Anti-HIV Agents; Chromatography, Liquid; Humans; Organophosphonates; Prodrugs; Tandem Mass Spectrometry; Tenofovir | 2018 |
Nano-Assembly of Pamitoyl-Bioconjugated Coenzyme-A for Combinatorial Chemo-Biologics in Transcriptional Therapy.
Topics: Adenine; Antineoplastic Agents; Cell Line, Tumor; Coenzyme A; Drug Carriers; Humans; Melanoma; Nanoparticles; Naphthalimides; Organophosphonates; Protein Multimerization; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; RNAi Therapeutics | 2018 |
Seroclearance of hepatitis B surface antigen following hepatitis E exacerbation on chronic hepatitis E and B dual infection in a renal transplant recipient: a case report.
Topics: Adenine; Coinfection; Disease Progression; DNA, Viral; Female; Graft Rejection; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis E; Hepatitis E virus; Humans; Immunosuppressive Agents; Kidney Transplantation; Lamivudine; Medication Adherence; Middle Aged; Organophosphonates; Reverse Transcriptase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Tacrolimus | 2018 |
USC-087 protects Syrian hamsters against lethal challenge with human species C adenoviruses.
Topics: Adenine; Adenovirus Infections, Human; Adenoviruses, Human; Administration, Oral; Animals; Antiviral Agents; Disease Models, Animal; Immunocompromised Host; Liver; Mesocricetus; Organophosphonates; Prodrugs; Survival Analysis; Treatment Outcome; Tyrosine | 2018 |
Injectable PLGA Adefovir microspheres; the way for long term therapy of chronic hepatitis-B.
Topics: Adenine; Animals; Antiviral Agents; Drug Delivery Systems; Drug Liberation; Hepatitis B, Chronic; Lactic Acid; Male; Microspheres; Organophosphonates; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats | 2018 |
Osteomalacia Due to Drug-Induced Fanconi Syndrome.
Topics: Adenine; Aged; Antiviral Agents; Fanconi Syndrome; Hepatitis B; Humans; Male; Organophosphonates; Osteomalacia | 2018 |
Hepatitis B virus rtA181T/sW172non-stop mutation may increase resistance fold to adefovir- and entecavir-resistant mutants compared to rtA181T/sW172* mutation.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase | 2018 |
Chronic hepatitis B virus and liver fibrosis: A mathematical model.
Topics: Adenine; Computer Simulation; Diffusion; Drug Delivery Systems; Hepatic Stellate Cells; Hepatitis B virus; Hepatitis B, Chronic; Humans; Inflammation; Interferon-alpha; Liver Cirrhosis; Macrophages; Models, Theoretical; Organophosphonates; Th2 Cells | 2018 |
Trends in hepatitis B virus resistance to nucleoside/nucleotide analogues in North China from 2009-2016: A retrospective study.
Topics: Adenine; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Child; Child, Preschool; China; DNA, Viral; Drug Resistance, Viral; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Mutation; Organophosphonates; Retrospective Studies; Telbivudine; Thymidine; Virus Activation; Virus Replication | 2018 |
Combination therapy for chronic hepatitis B: The future and beyond.
Topics: Adenine; Guanine; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Interferon-alpha; Organophosphonates; Polyethylene Glycols; Recombinant Proteins | 2018 |
Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity.
Topics: Adenine; Amino Acids; Animals; Antiviral Agents; Cell Line; Cercopithecidae; Dogs; Drug-Related Side Effects and Adverse Reactions; HEK293 Cells; Humans; Kidney; Kinetics; Macaca fascicularis; Mice; Organic Anion Transport Protein 1; Organophosphonates; Rats; Species Specificity; Uric Acid | 2018 |
Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Asian People; Female; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Young Adult | 2018 |
Development of rectal enema as microbicide (DREAM): Preclinical progressive selection of a tenofovir prodrug enema.
Topics: Adenine; Administration, Rectal; Alanine; Animals; Anti-HIV Agents; Anti-Infective Agents; Enema; HIV Infections; HIV-1; Homosexuality, Male; Male; Mice; Organophosphates; Organophosphonates; Pre-Exposure Prophylaxis; Prodrugs; Rectum; Sexual and Gender Minorities; Tenofovir | 2019 |
Clinical-features analysis on 926 patients with virological breakthrough in chronic hepatitis B receiving nucleos(t)ide analogues.
Topics: Adenine; Adult; DNA, Viral; Drug Administration Schedule; Drug Resistance, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Medication Adherence; Organophosphonates; Reverse Transcriptase Inhibitors; Sustained Virologic Response; Telbivudine; Thymidine | 2018 |
48-Week Outcome after Cessation of Nucleos(t)ide Analogue Treatment in Chronic Hepatitis B Patient and the Associated Factors with Relapse.
Topics: Adenine; Adult; Antiviral Agents; Female; Follow-Up Studies; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Male; Nucleosides; Organophosphonates; Outpatients; Prognosis; Prospective Studies; Recurrence; Risk Factors; RNA, Viral; Telbivudine; Time Factors; Treatment Outcome; Withholding Treatment | 2018 |
Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.
Topics: Adenine; Adenylyl Cyclases; Bacillus anthracis; Bordetella pertussis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Molecular Structure; Organophosphonates; Structure-Activity Relationship | 2018 |
[Compare the effect of combined therapy between telbivudine plus adefovir dipivoxil and lamivudine plus adefovir dipivoxil corresponding to renal function in patients with hepatitis B virus infection].
Topics: Adenine; Antiviral Agents; Creatinine; DNA, Viral; Drug Therapy, Combination; Glomerular Filtration Rate; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Lamivudine; Organophosphonates; Telbivudine; Treatment Outcome | 2018 |
Long-term results of chronic hepatitis B antiviral treatment with nucleos(t)ide analogues: a single center experience.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Antiviral Agents; Drug Therapy, Combination; Female; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Tenofovir; Young Adult | 2019 |
Deep sequencing identifies hepatitis B virus core protein signatures in chronic hepatitis B patients.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Female; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; High-Throughput Nucleotide Sequencing; Humans; Interferon-alpha; Linear Models; Male; Middle Aged; Models, Molecular; Organophosphonates; Polyethylene Glycols; Protein Conformation; Recombinant Proteins; Sequence Alignment; Sequence Analysis, Protein; Sequence Homology; Viral Core Proteins | 2018 |
[A Case of Fanconi's Syndrome Induced by Adefovir in Hepatitis Type B Patient].
Topics: Adenine; Aged; Antiviral Agents; Fanconi Syndrome; Female; Guanine; Hepatitis B, Chronic; Humans; Organophosphonates | 2016 |
Anticancer Activity and Topoisomerase II Inhibition of Naphthalimides with ω-Hydroxylalkylamine Side-Chains of Different Lengths.
Topics: Adenine; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Naphthalimides; Organophosphonates; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2019 |
Hypophosphatemic Osteomalacia Associated with Adefovir-induced Fanconi Syndrome Initially Diagnosed as Diabetic Kidney Disease and Vitamin D Deficiency.
Topics: Adenine; Aged; Antiviral Agents; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diagnostic Errors; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Hypophosphatemia; Male; Organophosphonates; Osteomalacia; Vitamin D Deficiency | 2019 |
Management of individuals with chronic hepatitis B virus infection and persistent normal or mildly elevated aminotransferase levels.
Topics: Adenine; Adult; Alanine Transaminase; Antiviral Agents; Biopsy; Disease Management; DNA, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Male; Organophosphonates; Retrospective Studies | 2019 |
Longitudinal trends in renal function in chronic hepatitis B patients receiving oral antiviral treatment.
Topics: Adenine; Administration, Oral; Adult; Aged; Antiviral Agents; Cohort Studies; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B, Chronic; Humans; Kidney; Longitudinal Studies; Male; Middle Aged; Nutrition Surveys; Organophosphonates; Retrospective Studies; Tenofovir | 2018 |
Octadecyloxyethyl Adefovir Exhibits Potent in vitro and in vivo Cytotoxic Activity and Has Synergistic Effects with Ara-C in Acute Myeloid Leukemia.
Topics: Adenine; Animals; Apoptosis; Caspases; Cell Cycle Checkpoints; Cytarabine; DNA Damage; Drug Compounding; Drug Resistance, Neoplasm; Drug Synergism; Female; Histones; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Organophosphonates; Poly(ADP-ribose) Polymerases; Transplantation, Heterologous; Tumor Cells, Cultured | 2018 |
Very late onset post-transplant diffuse large B cell lymphoma in a liver transplant recipient with hepatitis B: A case report.
Topics: Adenine; Antiviral Agents; Biopsy, Fine-Needle; Chemoradiotherapy; Guanine; Hepatitis B; Hepatitis B virus; Humans; Immunosuppressive Agents; Liver Transplantation; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Organophosphonates; Tomography, X-Ray Computed; Treatment Outcome; Virus Replication | 2018 |
Performance of serum HBcrAg in chronic hepatitis B patients with 8-year nucleos(t)ide analogs therapy.
Topics: Adenine; Adult; Antiviral Agents; Female; Guanine; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Organophosphonates; Retrospective Studies; Seroconversion | 2019 |
Synthesis and Biological Studies of New Multifunctional Curcumin Platforms for Anticancer Drug Delivery.
Topics: Adenine; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Chlorambucil; Curcumin; Drug Carriers; Drug Liberation; Humans; Naphthalimides; Organophosphonates; Phosphorylation; Prodrugs; Transcription Factor RelA | 2019 |
Telbivudine and adefovir dipivoxil combination therapy improves renal function in patients with chronic hepatitis B: A STROBE-compliant article.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hepatitis B virus; Hepatitis B, Chronic; Humans; Kidney Function Tests; Male; Middle Aged; Organophosphonates; Retrospective Studies; Telbivudine; Young Adult | 2018 |
Methylation status of the stimulator of interferon genes promoter in patients with chronic hepatitis B.
Topics: Adenine; Adult; Antiviral Agents; Biomarkers; DNA, Viral; Female; Guanine; Hepatitis B, Chronic; Humans; Leukocytes, Mononuclear; Male; Methylation; Middle Aged; Organophosphonates; Polymerase Chain Reaction; Promoter Regions, Genetic; RNA, Messenger; Sustained Virologic Response | 2018 |
The clinical and pathological features of adefovir dipivoxil-related renal impairment
.
Topics: Adenine; Adult; Antiviral Agents; Creatinine; Female; Glycosuria; Hematuria; Hepatitis B, Chronic; Humans; Hypophosphatemia; Kidney Tubules, Proximal; Male; Middle Aged; Mitochondria; Organophosphonates; Phosphorus; Proteinuria; Renal Insufficiency; Uric Acid | 2019 |
Synthesis and Antiviral Evaluation of 3'-Fluoro-4'-modified-5'-norcarbocyclic Nucleoside Phosphonates.
Topics: Adenine; Anti-HIV Agents; Blood Cells; Cell Survival; Drug Evaluation, Preclinical; Humans; Molecular Structure; Nucleosides; Organophosphonates; Structure-Activity Relationship; Tenofovir; Virus Replication | 2019 |
The different effects of adefovir dipivoxil and telbivudine on the prognosis of hepatitis b virus-related hepatocellular carcinoma patients after curative resection.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Liver Function Tests; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Nucleosides; Nucleotides; Organophosphonates; Prognosis; Retrospective Studies; Telbivudine | 2019 |
Toxic myopathy with multiple deletions in mitochondrial DNA associated with long-term use of oral anti-viral drugs for hepatitis B: A case study.
Topics: Adenine; Administration, Oral; Aged; Antiviral Agents; DNA, Mitochondrial; Female; Gene Deletion; Hepatitis B, Chronic; Humans; Lamivudine; Mitochondrial Myopathies; Muscle, Skeletal; Organophosphonates | 2019 |
Adefovir dipivoxil sensitizes colon cancer cells to vemurafenib by disrupting the KCTD12-CDK1 interaction.
Topics: Adenine; Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; Colonic Neoplasms; Humans; Organophosphonates; Protein Binding; Proteins; Reverse Transcriptase Inhibitors; Vemurafenib | 2019 |
Adefovir accumulation and nephrotoxicity in renal interstitium: Role of organic anion transporters of kidney.
Topics: Adenine; Animals; Antiviral Agents; Kidney Diseases; Kidney Tubules; Organic Anion Transporters; Organophosphonates; Rats; Rats, Wistar; Tissue Distribution | 2019 |
Entecavir and Low Genetic Barrier Antiviral Agents for Hepatocellular Carcinoma in Hepatitis B Viral Cirrhosis: Propensity Score Matching.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; China; Female; Guanine; Hepatitis B; Hepatitis B virus; Humans; Incidence; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Organophosphonates; Retrospective Studies; Risk Factors; Telbivudine | 2019 |
[Adefovir Dipivoxil-induced Fanconi's Syndrome and Osteomalacia Following Multiple Bone Fractures in a Patient with Chronic Hepatitis B].
Topics: Adenine; Aged; Carcinoma, Hepatocellular; Fanconi Syndrome; Fractures, Bone; Hepatitis B, Chronic; Humans; Hypophosphatemia; Liver Neoplasms; Male; Organophosphonates; Osteomalacia; Time Factors | 2019 |
[Marked improvement in renal tubular markers after switching from adefovir to tenofovir alafenamide in a case of Fanconi syndrome diagnosed through high ALP levels].
Topics: Adenine; Alanine; Alkaline Phosphatase; Antiviral Agents; Biomarkers; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Fanconi Syndrome; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Middle Aged; Organophosphonates; Tenofovir; Tomography, X-Ray Computed; Treatment Outcome | 2019 |
Denosumab improves clinical manifestations of hypophosphatemic osteomalacia by adefovir-induced Fanconi syndrome: a case report.
Topics: Adenine; Adult; Antiviral Agents; Bone Density Conservation Agents; Denosumab; Fanconi Syndrome; Hepatitis B; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteomalacia; Tomography, Emission-Computed; Treatment Outcome | 2019 |
Brca1 is involved in tolerance to adefovir dipivoxil‑induced DNA damage.
Topics: Adenine; Antiviral Agents; BRCA1 Protein; Cell Line; Chromosome Aberrations; DNA Damage; Gene Deletion; Hepatitis B, Chronic; Humans; Organophosphonates | 2019 |
Long-term Nucleotide Analogue Treatment Has Higher Levels of Renal Toxicities than Does Entecavir in Patients with Chronic Hepatitis B.
Topics: Adenine; Adult; Aged; Antiviral Agents; Chemical and Drug Induced Liver Injury; Female; Glomerular Filtration Rate; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Incidence; Male; Middle Aged; Nucleotides; Organophosphonates; Proportional Hazards Models; Retrospective Studies; Tenofovir; Time Factors; Treatment Outcome | 2020 |
Serum hepatitis B virus RNA levels as a predictor of HBeAg seroconversion during treatment with peginterferon alfa-2a.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Male; Middle Aged; Organophosphonates; Polyethylene Glycols; Recombinant Proteins; Retrospective Studies; ROC Curve; Seroconversion; Young Adult | 2019 |
Fibrosing Cholestatic Hepatitis-Like Syndrome in an Immunocompetent Patient With an Acute Flare of Chronic Hepatitis B.
Topics: Adenine; Biopsy, Needle; Cholestasis; Disease Progression; Follow-Up Studies; Hepatitis B, Chronic; Humans; Immunocompetence; Immunohistochemistry; Liver Cirrhosis; Liver Failure, Acute; Liver Function Tests; Male; Middle Aged; Organophosphonates; Severity of Illness Index; Syndrome; Telbivudine | 2019 |
Long-term prognosis of liver disease in patients with chronic hepatitis B virus infection receiving nucleos(t)ide analogue therapy: an analysis using a Markov chain model.
Topics: Adenine; Adult; Aged; Antiviral Agents; Carcinoma, Hepatocellular; Female; Guanine; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Lamivudine; Liver Cirrhosis; Liver Neoplasms; Male; Markov Chains; Middle Aged; Nucleosides; Organophosphonates; Prognosis | 2019 |
Low-dose adefovir dipivoxil-induced hypophosphatemia osteomalacia in five chronic hepatitis B virus-infected patients. Is low-dose adefovir dipivoxil-induced nephrotoxicity completely reversible?
Topics: Adenine; Aged; Dose-Response Relationship, Drug; Fanconi Syndrome; Female; Hepatitis B, Chronic; Humans; Hypophosphatemia; Kidney Diseases; Male; Middle Aged; Organophosphonates; Osteomalacia | 2019 |
Identification of novel adefovir dipivoxil-saccharin cocrystal polymorphs and their thermodynamic polymorphic transformations.
Topics: Adenine; Crystallization; Organophosphonates; Saccharin; Thermodynamics | 2019 |
Voltammetric determination of adefovir dipivoxil by using a nanocomposite prepared from molecularly imprinted poly(o-phenylenediamine), multi-walled carbon nanotubes and carbon nitride.
Topics: Adenine; Electrochemical Techniques; Electrodes; Humans; Limit of Detection; Molecular Imprinting; Nanocomposites; Nanotubes, Carbon; Nitriles; Organophosphonates; Phenylenediamines; Reproducibility of Results | 2019 |
In Vitro and In Vivo Renoprotective Effects of Telbivudine in Chronic Hepatitis B Patients Receiving Nucleotide Analogue.
Topics: Activating Transcription Factor 4; Adenine; Antiviral Agents; Apoptosis; Caspase 12; Cell Line; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Epithelial Cells; Female; Glomerular Filtration Rate; Heat-Shock Proteins; Hepatitis A Virus Cellular Receptor 1; Hepatitis B, Chronic; Humans; In Vitro Techniques; Interleukin-18; Kidney Tubules; Lamivudine; Lipocalin-2; Male; Middle Aged; Organophosphonates; Prospective Studies; Protective Agents; Renal Insufficiency, Chronic; Severity of Illness Index; Telbivudine; Tenofovir | 2019 |
Synthesis, pharmacological evaluation, and mechanistic study of adefovir mixed phosphonate derivatives bearing cholic acid and l-amino acid moieties for the treatment of HBV.
Topics: Adenine; Antiviral Agents; Cholic Acid; Hepatitis B virus; Humans; Organophosphonates | 2019 |
Quantification of adefovir and pitavastatin in human plasma and urine by LC-MS/MS: A useful tool for drug-drug interaction studies.
Topics: Adenine; Chromatography, High Pressure Liquid; Humans; Organophosphonates; Plasma; Quinolines; Tandem Mass Spectrometry | 2019 |
Immunomodulatory Mechanism of Acyclic Nucleoside Phosphates in Treatment of Hepatitis B Virus Infection.
Topics: Adenine; Adult; Aged; Antiviral Agents; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunomodulation; Interferon-alpha; Interleukin-10; Interleukin-12; Lamivudine; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Nucleosides; Organophosphonates; Proto-Oncogene Proteins c-akt; Tenofovir | 2020 |
Aminonaphthalimide hybrids of mitoxantrone and amonafide as anticancer and fluorescent cellular imaging agents.
Topics: Adenine; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Mitoxantrone; Naphthalimides; Organophosphonates; Phthalimides; Spectrometry, Fluorescence | 2019 |
In response to identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.
Topics: Adenine; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; Tenofovir | 2019 |
Reply to: "In response to identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients."
Topics: Adenine; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; Tenofovir | 2019 |
[Analysis of resistance mutations in patients with persistent low viral load during antiviral therapy with tebivudine alone or in combination with adefovir dipivoxil].
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; Telbivudine; Viral Load | 2019 |
Effect of nucleos(t)ide analogue on serum HBsAg level in chronic hepatitis B patients: A 3-years study.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Female; Guanine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Nucleotidases; Organophosphonates; Viral Load | 2020 |
Pregnancy outcomes for pregnant women with chronic hepatitis B exposing to entecavir or adefovir dipivoxil therapy before or in early pregnancy.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Organophosphonates; Pregnancy; Pregnancy Outcome; Pregnant Women; Retrospective Studies; Treatment Outcome; Viral Load | 2022 |
Adefovir dipivoxil induces DNA replication stress and augments ATR inhibitor-related cytotoxicity.
Topics: Adenine; Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; Cell Death; Cell Line, Tumor; Cell Proliferation; DNA Replication; Humans; Organophosphonates; Protein Kinase Inhibitors; Signal Transduction | 2020 |
Hypophosphatemic Osteomalacia Due to Adefovir-Induced Fanconi Syndrome.
Topics: Adenine; Aged; Alanine; Antiviral Agents; Fanconi Syndrome; Female; Hepatitis C, Chronic; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia; Tenofovir | 2020 |
Retrospective analysis of the clinical characteristics of adefovir dipivoxil-induced Fanconi's syndrome in the Chinese population.
Topics: Adenine; Adult; Aged; Alkaline Phosphatase; Asian People; Bone Density; Fanconi Syndrome; Female; Glycosuria; Humans; Hypophosphatemia; Male; Middle Aged; Organophosphonates; Osteoporosis; Retrospective Studies; Young Adult | 2020 |
Osteomalacia and renal failure due to Fanconi syndrome caused by long-term low-dose Adefovir Dipivoxil: a case report.
Topics: Adenine; Antiviral Agents; Fanconi Syndrome; Hepatitis B, Chronic; Humans; Male; Middle Aged; Organophosphonates; Osteomalacia; Renal Insufficiency | 2020 |
Stabilized oral nanostructured lipid carriers of Adefovir Dipivoxil as a potential liver targeting: Estimation of liver function panel and uptake following intravenous injection of radioiodinated indicator.
Topics: Adenine; Administration, Oral; Animals; Chemical and Drug Induced Liver Injury; Drug Stability; Injections, Intravenous; Iodine Radioisotopes; Lipids; Liver; Liver Function Tests; Mice; Nanoparticles; Organophosphonates; Particle Size; Rose Bengal; Thioacetamide | 2020 |
Hepatitis B virus mutation pattern rtA181S+T184I+M204I may contribute to multidrug resistance in clinical practice: Analysis of a large cohort of Chinese patients.
Topics: Adenine; Adult; Antiviral Agents; Asian People; Beijing; Cohort Studies; DNA, Viral; Drug Resistance, Multiple, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Longitudinal Studies; Male; Middle Aged; Mutation; Organophosphonates; Prevalence | 2020 |
Is tenofovir and entecavir combination therapy still the optimal treatment for chronic hepatitis B patients with prior suboptimal response?
Topics: Adenine; Guanine; Hepatitis B, Chronic; Humans; Lamivudine; Organophosphonates; Telbivudine; Tenofovir | 2020 |
An antiviral drug-resistant mutant of hepatitis B virus with high replication capacity in association with a large in-frame deletion in the preS1 region of viral surface gene.
Topics: Adenine; Adult; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Genes, Viral; Genotype; Hepatitis B Surface Antigens; Hepatitis B, Chronic; Humans; Male; Mutation; Organophosphonates | 2020 |
Adefovir dipivoxil efficiently inhibits the proliferation of pseudorabies virus in vitro and in vivo.
Topics: Adenine; Animals; Antiviral Agents; Cell Line; Drug Discovery; Herpesvirus 1, Suid; High-Throughput Screening Assays; Mice; Mice, Inbred BALB C; Organophosphonates; Pseudorabies; Small Molecule Libraries; Swine; Virus Replication | 2021 |
Multiple drug-resistant HBV mutation may contribute to poor response of adefovir + entecavir in entecavir-resistant patients.
Topics: Adenine; Adult; Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Drug Therapy, Combination; Female; Genotype; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Male; Middle Aged; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Tenofovir; Viral Load; Virus Replication | 2021 |
Severe hypophosphataemic osteomalacia related to low-dose adefovir dipivoxil therapy in a hepatitis B virus patient.
Topics: Adenine; Antiviral Agents; Hepatitis B virus; Hepatitis B, Chronic; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia | 2021 |
Investigation of multidrug-resistance mutations of hepatitis B virus (HBV) in a large cohort of chronic HBV-infected patients with treatment of nucleoside/nucleotide analogs.
Topics: Adenine; Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Drug Resistance, Multiple, Viral; Female; Guanine; Hepatitis B virus; Hepatitis B, Chronic; Humans; Lamivudine; Longitudinal Studies; Male; Middle Aged; Mutation; Nucleosides; Nucleotides; Organophosphonates; Phylogeny; Telbivudine; Viral Load; Virus Replication | 2021 |
Synthesis, electrochemistry, DNA binding and in vitro cytotoxic activity of tripodal ferrocenyl bis-naphthalimide derivatives.
Topics: Adenine; Antineoplastic Agents; Cell Line, Tumor; DNA; Drug Screening Assays, Antitumor; Electrochemistry; Ethidium; Ferrous Compounds; Flow Cytometry; Humans; Metallocenes; Molecular Structure; Naphthalimides; Organophosphonates; Reactive Oxygen Species; Structure-Activity Relationship | 2021 |
[Adefovir-induced osteomalacia and hypophosphatemia].
Topics: Adenine; Humans; Hypophosphatemia; Organophosphonates; Osteomalacia | 2022 |
Targeted methylation facilitates DNA double strand breaks and enhances cancer suppression: A DNA intercalating/methylating dual-action chimera Amonafidazene.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Proliferation; DNA Breaks, Double-Stranded; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Organophosphonates; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Effect of Coformer Selection on In Vitro and In Vivo Performance of Adefovir Dipivoxil Cocrystals.
Topics: Acetaminophen; Adenine; Animals; Area Under Curve; Caco-2 Cells; Cell Membrane Permeability; Chemistry, Pharmaceutical; Crystallization; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Models, Biological; Molecular Conformation; Niacinamide; Organophosphonates; Rats; Saccharin; Solubility; Water | 2021 |
Drastic Modulation of Molecular Packing and Intrinsic Dissolution Rates by Meniscus-Guided Coating of Extremely Confined Pharmaceutical Thin Films.
Topics: Adenine; Coated Materials, Biocompatible; Humans; Irinotecan; Microscopy, Atomic Force; Molecular Structure; Nanoparticles; Organophosphonates; Particle Size; Surface Properties; X-Ray Diffraction | 2021 |
Adefovir accumulation in the renal interstitium triggers mast cell degranulation and promotes renal interstitial fibrosis.
Topics: Adenine; Animals; Cell Degranulation; Disease Models, Animal; Fibrosis; Humans; Kidney Diseases; Kidney Tubules; Male; Mast Cells; Organophosphonates; Rats | 2022 |
CKD in a Patient Treated with Adefovir for Chronic Hepatitis B Virus Infection.
Topics: Adenine; Antiviral Agents; Hepatitis B, Chronic; Humans; Organophosphonates; Renal Insufficiency, Chronic | 2021 |
Novel hepatitis B virus reverse transcriptase mutations in patients with sustained viremia despite long-term tenofovir treatment.
Topics: Adenine; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Hepatitis B virus; Hepatitis B, Chronic; Humans; Mutation; Organophosphonates; RNA-Directed DNA Polymerase; Tenofovir; Viremia | 2022 |
The making of the one pill-Developing single tablet regimens for HIV and for HCV.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Hepatitis C; HIV Infections; Humans; Organophosphonates; Tablets | 2022 |
The transformation of HIV therapy: One pill once a day.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Drug Combinations; HIV Infections; Humans; Organophosphonates; Tablets | 2022 |
Similar risk of kidney function decline between tenofovir alafenamide and besifovir dipivoxil maleate in chronic hepatitis B.
Topics: Adenine; Alanine; Antiviral Agents; Guanine; Hepatitis B; Hepatitis B, Chronic; Humans; Kidney; Longitudinal Studies; Maleates; Organophosphonates; Renal Insufficiency, Chronic; Retrospective Studies; Tenofovir; Treatment Outcome | 2022 |
Discovery of an L-like Configuration for 3'-Fluoro-5'-norcarbonucleoside Phosphonates as Potent Anti-HIV Agents.
Topics: Adenine; Anti-HIV Agents; Antiviral Agents; Nucleosides; Organophosphonates; Prodrugs; Tenofovir | 2022 |
An Improved Scalable Synthesis of the Potent Antiviral (S)-HPMPA.
Topics: 2-Propanol; Adenine; Antiviral Agents; Ethanol; Organophosphonates; Sodium | 2022 |
Synthesis, antiviral activity, and computational study of β-d-xylofuranosyl nucleoside phosphonates.
Topics: Adenine; Antiviral Agents; Nucleosides; Organophosphonates; RNA; Structure-Activity Relationship | 2023 |
The expression of interleukin-1β in patients with chronic hepatitis B treated with pegylated-interferon-alpha combined with tenofovir disoproxil fumarate and monotherapy.
Topics: Adenine; Antiviral Agents; Carcinoma, Hepatocellular; Cohort Studies; DNA, Viral; Drug Therapy, Combination; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Interferon-alpha; Interleukin-1beta; Liver Neoplasms; Organophosphonates; Polyethylene Glycols; Prospective Studies; Tenofovir; Treatment Outcome | 2023 |
Counterfactual estimation of efficacy against placebo for novel PrEP agents using external trial data: example of injectable cabotegravir and oral PrEP in women.
Topics: Adenine; Anti-HIV Agents; Deoxycytidine; Emtricitabine; Female; HIV Infections; Humans; Organophosphonates; Pre-Exposure Prophylaxis | 2023 |