org 31710 has been researched along with mifepristone in 20 studies
| Studies (org 31710) | Trials (org 31710) | Recent Studies (post-2010) (org 31710) | Studies (mifepristone) | Trials (mifepristone) | Recent Studies (post-2010) (mifepristone) |
|---|---|---|---|---|---|
| 38 | 3 | 6 | 6,536 | 595 | 1,758 |
| Protein | Taxonomy | org 31710 (IC50) | mifepristone (IC50) |
|---|---|---|---|
| Glucocorticoid receptor | Canis lupus familiaris (dog) | 0.0264 | |
| Bile salt export pump | Homo sapiens (human) | 2.02 | |
| Estrogen receptor | Homo sapiens (human) | 4.311 | |
| Glucocorticoid receptor | Homo sapiens (human) | 0.0249 | |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | 0.0003 | |
| Progesterone receptor | Homo sapiens (human) | 0.1347 | |
| Glucocorticoid receptor | Rattus norvegicus (Norway rat) | 0.774 | |
| Glucocorticoid receptor | Mus musculus (house mouse) | 0.0022 | |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | 0.0022 | |
| Mineralocorticoid receptor | Homo sapiens (human) | 2.0938 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 9.5 | |
| Coagulation factor VII | Homo sapiens (human) | 0.0003 | |
| Androgen receptor | Homo sapiens (human) | 0.2988 | |
| Cytochrome P450 2C8 | Homo sapiens (human) | 1.5 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 4.9 | |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Rattus norvegicus (Norway rat) | 0.0016 | |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | 0.555 | |
| Tissue factor | Homo sapiens (human) | 0.0003 | |
| Androgen receptor | Rattus norvegicus (Norway rat) | 0.0083 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0014 | |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | 0.0022 | |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | 0.0022 | |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | 0.0078 | |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | 0.0022 | |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | 0.0015 | |
| Mu-type opioid receptor | Homo sapiens (human) | 2.457 | |
| Estrogen receptor beta | Homo sapiens (human) | 1.528 | |
| Glucocorticoid receptor | Sus scrofa (pig) | 0.0153 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 8 (40.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhakta, A; Kloosterboer, HJ; Mizutani, T; Moudgil, VK | 1 |
| de Gooyer, ME; Deckers, GH; Dijkema, R; Kloosterboer, HJ; Orlemans, EO; Schoonen, WG | 1 |
| Deckers, GH; Kloosterboer, HJ; Schoonen, WG | 1 |
| Joosten, JW; Kloosterboer, HJ; Schoonen, WG | 1 |
| Cornish, AL; Lee, CS; Musgrove, EA; Sutherland, RL; Swarbrick, A | 1 |
| Koper, JW; Lamberts, SW; Molijn, GJ; Stigter, E; van Uffelen, CJ | 1 |
| Dinda, S; Herman, M; Hurd, C; Iwasaki, K; Kloosterboer, HJ; Moudgil, VK; Underwood, B | 1 |
| Bellido, C; de Jong, FH; Sánchez-Criado, JE; Tébar, M | 1 |
| Andersson, M; Billig, H; Markström, E; Shao, R; Svensson, EC | 1 |
| Billig, H; Friberg, PA; Johansson, M; Markström, E; Shao, R | 1 |
| Billig, H; Carlsson, B; Carlsson, LM; Friberg, PA; Larsson, DG; Nielsen, ECh; Rung, E; Shao, R; Svensson, PA | 1 |
| Billig, H; Egecioglu, E; Fernandez-Rodriguez, J; Friberg, A; Ljungström, K; Rung, E; Shao, R; Wang, X; Weijdegård, B; Zhu, C; Zhu, Y | 1 |
| Bergh, C; Billig, H; Friberg, PA; Rung, E | 1 |
| Billig, H; Egecioglu, E; Fernandez-Rodriguez, J; Ling, C; Ljungström, K; Shao, R; Weijdegård, B | 1 |
| Billig, H; Friberg, PA; Larsson, DG | 1 |
| Goyeneche, AA; Seidel, EE; Telleria, CM | 1 |
| Bennett, PR; Brosens, JJ; Chen, L; Georgiou, EX; Johnson, MR; Khanjani, S; Lei, K; Sooranna, SR | 1 |
| Gamarra-Luques, CD; Goyeneche, AA; Hapon, MB; Telleria, CM | 1 |
| Chen, LC; Hsu, SP; Huo, YN; Kuo, CT; Lee, WS; Wen, HC; Yang, HC | 1 |
| Basar, M; Bozkurt, I; Buchwalder, L; Guzel, E; Kayisli, U; Lockwood, CJ; Ocak, N; Schatz, F | 1 |
20 other study(ies) available for org 31710 and mifepristone
| Article | Year |
|---|---|
Novel antiprogestins Org 31806 and 31710: interaction with mammalian progesterone receptor and DNA binding of antisteroid receptor complexes.
Topics: Animals; Cattle; Chickens; Cytosol; DNA; Estrenes; Female; Furans; Kinetics; Mifepristone; Progesterone; Progestins; Promegestone; Receptors, Progesterone; Species Specificity; Uterus | 1992 |
Pharmacological properties of a new selective antiprogestagen: Org 33628.
Topics: Adrenal Glands; Animals; Cell Line; Estrenes; Female; Furans; Gonanes; Guinea Pigs; Humans; In Vitro Techniques; Mifepristone; Ovulation; Pregnancy; Progestins; Receptors, Cell Surface; Receptors, Progesterone; Structure-Activity Relationship | 1995 |
Pharmacology of two new very selective antiprogestagens: Org 31710 and Org 31806.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Abortifacient Agents, Steroidal; Abortion, Induced; Androgen Antagonists; Animals; Estrenes; Female; Furans; Gonanes; Macaca; Male; Mammary Neoplasms, Experimental; Menstruation-Inducing Agents; Mifepristone; Pregnancy; Progestins; Rats; Receptors, Glucocorticoid; Receptors, Progesterone | 1994 |
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines.
Topics: Breast Neoplasms; Carcinoma; Cell Division; Desogestrel; Dose-Response Relationship, Drug; Estradiol; Estrenes; Estrogen Antagonists; Female; Furans; Humans; Levonorgestrel; Medroxyprogesterone Acetate; Mifepristone; Nandrolone; Norethindrone; Norpregnenes; Pregnanes; Pregnenediones; Progesterone; Promegestone; Tumor Cells, Cultured | 1995 |
Antiprogestin inhibition of cell cycle progression in T-47D breast cancer cells is accompanied by induction of the cyclin-dependent kinase inhibitor p21.
Topics: Breast Neoplasms; Cell Cycle; Cell Division; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Drug Resistance; Estrenes; Furans; Hormone Antagonists; Humans; Mifepristone; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Oncogene Proteins; Phosphorylation; Progestins; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Retinoblastoma Protein; Tumor Cells, Cultured | 1997 |
Antiprogestins and iatrogenic glucocorticoid resistance.
Topics: Binding, Competitive; Dexamethasone; Drug Resistance; Estrenes; Furans; Glucocorticoids; Gonanes; Hormone Antagonists; Humans; Hydrocortisone; In Vitro Techniques; Lymphocyte Activation; Meningeal Neoplasms; Meningioma; Mifepristone; Progestins; Receptors, Glucocorticoid | 1997 |
Characterization of ligand binding, DNA binding and phosphorylation of progesterone receptor by two novel progesterone receptor antagonist ligands.
Topics: Binding, Competitive; Blotting, Western; DNA; Electrophoresis, Polyacrylamide Gel; Estrenes; Furans; Gonanes; Hormone Antagonists; Humans; Ligands; Mifepristone; Phosphorylation; Progesterone Congeners; Promegestone; Receptors, Progesterone; Sodium Dodecyl Sulfate; Tumor Cells, Cultured | 1997 |
Comparison of the effects of antiprogestins RU38486, ZK98299 and ORG31710 on periovulatory hypophysial, ovarian and adrenal hormone secretion in the rat.
Topics: Adrenal Glands; Animals; Corticosterone; Estrenes; Female; Follicle Stimulating Hormone; Furans; Gonanes; Hormone Antagonists; Inhibins; Luteinizing Hormone; Mifepristone; Ovary; Ovulation; Pituitary Gland, Posterior; Progesterone; Rats; Rats, Wistar | 2000 |
Progesterone receptor antagonists Org 31710 and RU 486 increase apoptosis in human periovulatory granulosa cells.
Topics: Caspase 3; Caspases; Dexamethasone; Dihydrotestosterone; DNA Fragmentation; Electrophoresis, Agar Gel; Estrenes; Female; Furans; GABA Antagonists; Glucocorticoids; Granulosa Cells; Hormone Antagonists; Humans; Mifepristone; Nucleosomes; Picrotoxin; Progesterone; Receptors, GABA-A; Receptors, Progesterone; Spectrometry, Fluorescence | 2001 |
Expression of progesterone receptor (PR) A and B isoforms in mouse granulosa cells: stage-dependent PR-mediated regulation of apoptosis and cell proliferation.
Topics: Animals; Apoptosis; Blotting, Western; Caspase 3; Caspases; Cell Division; Chorionic Gonadotropin; Estrenes; Female; Furans; Granulosa Cells; Hormone Antagonists; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mifepristone; Ovarian Follicle; Proliferating Cell Nuclear Antigen; Protein Isoforms; Random Allocation; Receptors, Progesterone | 2003 |
Progesterone-receptor antagonists and statins decrease de novo cholesterol synthesis and increase apoptosis in rat and human periovulatory granulosa cells in vitro.
Topics: Animals; Apoptosis; Cell Survival; Cholesterol; Estrenes; Female; Furans; Gene Expression Profiling; Gene Expression Regulation; Granulosa Cells; Hormone Antagonists; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Mifepristone; Oligonucleotide Array Sequence Analysis; Ovulation; Rats; Rats, Sprague-Dawley; Receptors, Progesterone; Signal Transduction | 2005 |
Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function.
Topics: Animals; Apoptosis; Blotting, Western; Chorionic Gonadotropin; Epidermal Growth Factor; ErbB Receptors; Estradiol; Estrenes; Fallopian Tubes; Female; Furans; Gene Expression Regulation; Hormone Antagonists; Horses; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mifepristone; Organ Size; Progesterone; Receptors, Progesterone; Uterus | 2006 |
Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells.
Topics: Apoptosis; Cells, Cultured; Cholesterol; Diterpenes; Estrenes; Farnesol; Farnesyltranstransferase; Female; Furans; Granulosa Cells; Hormone Antagonists; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Leucine; Mifepristone; Ovulation; Protein Prenylation; Quinolones; Receptors, Progesterone | 2006 |
Developmental and hormonal regulation of progesterone receptor A-form expression in female mouse lung in vivo: interaction with glucocorticoid receptors.
Topics: Animals; Blotting, Western; Dexamethasone; Estrenes; Female; Furans; Gene Expression Regulation, Developmental; Glucocorticoids; Immunohistochemistry; Immunoprecipitation; Lung; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Mifepristone; Progesterone; Protein Isoforms; Receptors, Glucocorticoid; Receptors, Progesterone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis.
Topics: Animals; Antibodies, Blocking; Apoptosis; Cyanoketone; Dose-Response Relationship, Drug; Estrenes; Female; Furans; Granulosa Cells; Membrane Proteins; Mifepristone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Progesterone | 2009 |
Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cytostatic Agents; DNA Fragmentation; Estrenes; Female; Furans; Hormone Antagonists; Humans; Mifepristone; Norpregnadienes; Ovarian Neoplasms | 2012 |
Progesterone acts via the nuclear glucocorticoid receptor to suppress IL-1β-induced COX-2 expression in human term myometrial cells.
Topics: Cell Nucleus; Cells, Cultured; Cyclooxygenase 2; Estrenes; Female; Furans; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Gene Silencing; Genes, Reporter; Humans; Interleukin-1beta; Mifepristone; Myometrium; NF-kappa B; Progesterone; Receptors, Glucocorticoid; Receptors, Progesterone; RNA, Small Interfering; Transcription Factor RelA | 2012 |
Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity.
Topics: Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Estrenes; Female; Furans; Hormone Antagonists; Humans; Inhibitory Concentration 50; Mifepristone; Norpregnadienes; Paclitaxel | 2014 |
Progesterone receptor-NFκB complex formation is required for progesterone-induced NFκB nuclear translocation and binding onto the p53 promoter.
Topics: Active Transport, Cell Nucleus; Butadienes; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Estrenes; Flavonoids; Furans; Gene Expression Regulation; Hormone Antagonists; Humans; Mifepristone; NF-kappa B; Nitriles; Progesterone; Promoter Regions, Genetic; Protein Binding; Receptors, Progesterone; Sulfones; Tumor Suppressor Protein p53 | 2015 |
Effects of tibolone and its metabolites on prolactin and insulin-like growth factor binding protein-1 expression in human endometrial stromal cells.
Topics: Blotting, Western; Contraceptive Agents, Female; Dexamethasone; Endometrium; Enzyme-Linked Immunosorbent Assay; Estradiol; Estrenes; Estrogen Receptor Modulators; Estrogens; Female; Furans; Glucocorticoids; Hormone Antagonists; Humans; Insulin-Like Growth Factor Binding Protein 1; Medroxyprogesterone Acetate; Mifepristone; Norpregnanes; Norpregnenes; Prolactin; Real-Time Polymerase Chain Reaction; RNA, Messenger; Stromal Cells | 2015 |