Compounds > org 30659
Page last updated: 2024-09-04

org 30659 and norethindrone

org 30659 has been researched along with norethindrone in 8 studies

Compound Research Comparison

Studies
(org 30659)		Trials
(org 30659)		Recent Studies (post-2010)
(org 30659)		Studies
(norethindrone)		Trials
(norethindrone)		Recent Studies (post-2010) (norethindrone)
8104,295884303

Protein Interaction Comparison

ProteinTaxonomyorg 30659 (IC50)norethindrone (IC50)
Estrogen receptorHomo sapiens (human)0.808
Glucocorticoid receptorHomo sapiens (human)0.433
Progesterone receptorHomo sapiens (human)0.0032
Glycine receptor subunit alpha-1Rattus norvegicus (Norway rat)0.433
Androgen receptorRattus norvegicus (Norway rat)0.0711
Glycine receptor subunit betaRattus norvegicus (Norway rat)0.433
Glycine receptor subunit alpha-2Rattus norvegicus (Norway rat)0.433
Glycine receptor subunit alpha-3Rattus norvegicus (Norway rat)0.433
Sodium-dependent serotonin transporterHomo sapiens (human)4.537

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (37.50)18.2507
2000's5 (62.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Joosten, JW; Kloosterboer, HJ; Schoonen, WG2
Booy, CJ; Groothuis, GM; Krebbers, SF; Olinga, P; Verhoeven, CH; Vos, RM; Wagenaars, GN1
Gloudemans, RH; Groothuis, GM; Rietjens, IM; Verhoeven, CH; Vos, RM1
Huber, J; Killick, SR; Korver, T; Landgren, B; Obruca, A; Struijs, MJ1
Groothuis, GM; Rietjens, IM; van Munster, TT; Verhoeven, CH; Vos, RM1
Cohen, AF; de Visser, SJ; Fukazawa, I; Machielsen, CS; Uchida, E; Uchida, N; van den Heuvel, MW; van Doorn, MB; van Vliet-Daskalopoulou, E1
Nieuwmeyer, F; van der Voort Maarschalk, K; Vromans, H1

Trials

1 trial(s) available for org 30659 and norethindrone

ArticleYear
Ovarian function during and after treatment with the new progestagen Org 30659.
    Fertility and sterility, 2001, Volume: 76, Issue:1

    Topics: Adult; Desogestrel; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Norethindrone; Ovary; Ovulation; Progesterone Congeners; Progestins; Ultrasonography

2001

Other Studies

7 other study(ies) available for org 30659 and norethindrone

ArticleYear
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: I. MCF-7 cell lines.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 55, Issue:3-4

    Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Desogestrel; Estradiol; Estrogen Antagonists; Female; Humans; Levonorgestrel; Medroxyprogesterone Acetate; Models, Statistical; Nandrolone; Norethindrone; Norpregnenes; Pregnanes; Pregnenediones; Progesterone; Promegestone; Receptors, Androgen; Receptors, Estrogen; Receptors, Progesterone; Tumor Cells, Cultured

1995
Effects of two classes of progestagens, pregnane and 19-nortestosterone derivatives, on cell growth of human breast tumor cells: II. T47D cell lines.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 55, Issue:3-4

    Topics: Breast Neoplasms; Carcinoma; Cell Division; Desogestrel; Dose-Response Relationship, Drug; Estradiol; Estrenes; Estrogen Antagonists; Female; Furans; Humans; Levonorgestrel; Medroxyprogesterone Acetate; Mifepristone; Nandrolone; Norethindrone; Norpregnenes; Pregnanes; Pregnenediones; Progesterone; Promegestone; Tumor Cells, Cultured

1995
In vitro and in vivo metabolism of the progestagen Org 30659 in several species.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:11

    Topics: Animals; Chromatography, High Pressure Liquid; Feces; Female; Humans; Macaca fascicularis; Microsomes, Liver; Norethindrone; Rabbits; Rats; Rats, Wistar; Species Specificity; Tritium

1998
Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women.
    The Journal of steroid biochemistry and molecular biology, 2000, Volume: 73, Issue:1-2

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Feces; Female; Glucuronides; Haplorhini; Humans; In Vitro Techniques; Liver; Menopause; Middle Aged; Norethindrone; Progesterone Congeners; Rats; Species Specificity

2000
Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones Org 4060 and Org 30659.
    Xenobiotica; the fate of foreign compounds in biological systems, 2002, Volume: 32, Issue:2

    Topics: Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Microsomes, Liver; Norethindrone; Oxidoreductases, N-Demethylating

2002
Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE).
    Contraception, 2003, Volume: 68, Issue:3

    Topics: Adult; Area Under Curve; Asian People; Contraceptives, Oral, Combined; Ethinyl Estradiol; Female; Half-Life; Humans; Japan; Netherlands; Norethindrone; Sex Hormone-Binding Globulin; White People

2003
Lactose contaminant as steroid degradation enhancer.
    Pharmaceutical research, 2008, Volume: 25, Issue:11

    Topics: Drug Contamination; Drug Stability; Excipients; Hydrogen-Ion Concentration; Lactose; Norethindrone; Particle Size

2008