org-24461 and 7-chlorokynurenic-acid

org-24461 has been researched along with 7-chlorokynurenic-acid* in 1 studies

Other Studies

1 other study(ies) available for org-24461 and 7-chlorokynurenic-acid

ArticleYear
Temporal alteration of spreading depression by the glycine transporter type-1 inhibitors NFPS and Org-24461 in chicken retina.
    Brain research, 2013, Jan-25, Volume: 1492

    We used isolated chicken retina to induce spreading depression by the glutamate receptor agonist N-methyl-d-aspartate. The N-methyl-d-aspartate-induced latency time of spreading depression was extended by the glycine(B) binding site competitive antagonist 7-chlorokynurenic acid. Addition of the glycine transporter type-1 inhibitors NFPS and Org-24461 reversed the inhibitory effect of 7-chlorokynurenic acid on N-methyl-d-aspartate-evoked spreading depression. The glycine uptake inhibitory activity of Org-24461, NFPS, and some newly synthesized analogs of NFPS was determined in CHO cells stably expressing human glycine transporter type-1b isoform. Compounds, which failed to inhibit glycine transporter type-1, also did not have effect on retinal spreading depression. These experiments indicate that the spreading depression model in chicken retina is a useful in vitro test to determine activity of glycine transporter type-1 inhibitors. In addition, our data serve further evidence for the role of glycine transporter type-1 in retinal neurotransmission and light processing.

    Topics: Animals; Chickens; CHO Cells; Cortical Spreading Depression; Cricetinae; Cricetulus; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine Plasma Membrane Transport Proteins; Humans; Kynurenic Acid; N-Methylaspartate; Retina; Sarcosine

2013