orabase and methylparaben

Many weapons are available in the arsenal of a dental professional to combat dental caries, which is almost ubiquitously present. From a public health perspective, most of these weapons are far from being an ideal drug. Hence, there is a demand for better and effective antibacterial agents. This factor stimulated the process of the present study. The aim of the study was to determine the effect of ethanol extract of Terminalia chebula on Streptococcus mutans.. Dried ripe fruits of Terminalia chebula were procured and powdered. Physical tests were done to estimate purity of the fruit powder. Hydroethanolic and aqueous extracts were prepared according to standard procedures. Minimum inhibitory concentration of the extracts was determined by tube dilution method and confirmed by agar dilution method. The effect of the hydroethanolic extract on sucrose induced adhesion, glucan-induced aggregation and on glycolysis of Streptococcus mutans was also assessed. Preservative, gelling agent and sweetener were added in suitable quantities to the ethanol extract, and mouthrinse was formulated. Minimum inhibitory concentration of the formulation was also determined.. Yield was better in case of aqueous extract. The Minimum inhibitory concentration of hydroethanolic extract was determined to be 2.5%. Minimum inhibitory concentration of the aqueous extract was determined to be 10%. Hydroethanolic extract of Terminalia chebula (2.5%) inhibited sucrose induced adherence and aggregation of Streptococcus mutans in vitro.. The mouthrinse formulated from ethanol extract of Terminalia chebula demonstrated substantial antibacterial activity and could be used as an effective anticaries agent.. Terminalia chebula mouthrinse can be effectively used in clinical practice as an anticaries mouthrinse with additional benefit being that it is safe and economical.

Topics: Anti-Bacterial Agents; Bacterial Adhesion; Carboxymethylcellulose Sodium; Cariogenic Agents; Cariostatic Agents; Chemistry, Pharmaceutical; Ethanol; Fruit; Glucans; Glycolysis; Humans; Mannitol; Materials Testing; Microbial Sensitivity Tests; Mouthwashes; Parabens; Phytotherapy; Plant Extracts; Polysaccharides, Bacterial; Preservatives, Pharmaceutical; Solvents; Streptococcus mutans; Sucrose; Sweetening Agents; Terminalia; Water

Gels of tenoxicam 1% w/w were formulated using 2% w/w hydroxy propyl guar derivative and 3% w/w sodium carboxy methyl cellulose as gelling agents. A detailed rheological investigation was carried out to study the influence of preservative, drug and preservative, solvent system and the preservative, drug, solvent system and the preservative on the pseudoplastic behaviour of polymers. Hydroxy propyl guar derivative in 2% w/w strength resulted in gels with a higher pseudoplastic index value of 3.383 in contrast to an index value of 1.797 for a 3% w/w sodium carboxy methyl cellulose gels of a similar composition. The gels were stored at different temperatures and variations in pH values were recorded. Hydroxy propyl guar derivative based gels revealed variations in pH values over a narrow range in contrast to sodium carboxy methyl cellulose gels. The gels were subjected to short term stability studies by storing gels at refrigerated temperature, lab temperature, at 37 degrees C and at 45 degrees C. Gels based on hydroxy propyl guar derivative revealed better drug keeping qualities in contrast to sodium carboxy methyl cellulose stabilized gels. Release studies of tenoxicam from formulations across hairless albino mice skin revealed a zero order drug release pattern from both the formulations.

Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carboxymethylcellulose Sodium; Chemistry, Pharmaceutical; Drug Carriers; Drug Stability; Drug Storage; Ethanol; Gels; Hydrogen-Ion Concentration; Kinetics; Mice; Mice, Hairless; Models, Biological; Organ Culture Techniques; Parabens; Piroxicam; Polymers; Polysaccharides; Preservatives, Pharmaceutical; Propylene Glycols; Rheology; Skin Absorption; Solubility; Solvents; Temperature; Time Factors; Viscosity