orabase and iotrolan

To evaluate the additional effect of bioadhesives in combination with iotrolan and barium as oral contrast media in an animal model.. The bioadhesives Noveon, CMC, Tylose and Carbopol 934 were added to iotrolan and barium. The solutions were administered to rabbits by a feeding tube. The animals were investigated by computed tomography (CT) and radiography after 0.5, 4, 12, 24 and in part after 48 hours. Mucosal coating and contrast filling of the bowel were evaluated.. Addition of bioadhesives to oral contrast media effected long-term contrast in the small intestine and colon, but no improvement in continuous filling and coating of the gastrointestinal tract was detected. Mucosal coating was seen only in short regions of the caecum and small intestine. In CT the best results for coating were observed with tylose and CMC, in radiography additionally with carbopol and noveon. All contrast medium were well tolerated.. The evaluated contrast medium solutions with bioadhesives have shown long-term contrast but no improvement in coating in comparison to conventional oral contrast media.

Topics: Acrylic Resins; Adhesiveness; Adhesives; Administration, Oral; Animals; Barium Sulfate; Carboxymethylcellulose Sodium; Contrast Media; Digestive System; Drug Carriers; Drug Evaluation; Gels; Methylcellulose; Pharmaceutic Aids; Polyvinyls; Rabbits; Tomography, X-Ray Computed; Triiodobenzoic Acids