orabase and dodecylamine

orabase has been researched along with dodecylamine* in 2 studies

Other Studies

2 other study(ies) available for orabase and dodecylamine

Article	Year
Dissolution of amorphous nifedipine from micelle-forming carboxymethylcellulose derivatives. Carbohydrate polymers, 2020, Nov-01, Volume: 247 We show that a novel amphiphilic graft copolymer combining the biodegradability and biocompatibility of oxidized carboxymethylcellulose (CMC) with that of hydrophilic poly(ethylene glycol) (PEG), and hydrophobic dodecylamine (DDA), improves the solubility and dissolution performance of nifedipine (NIF), considered as a model hydrophobic drug. The hydrophobic components of the graft copolymer have the multiple effect of favouring micelle formation and loading. At the same time, the interaction between the hydrophobic core and NIF has the secondary effect to suppress drug crystallization, favouring its dissolution, and to increase photostability. Oxidized CMC-g-PEG-DDA micelles reached values of drug concentration, loading capacity and encapsulation efficiency as high as 340 μg mL Topics: Amines; Biocompatible Materials; Calorimetry, Differential Scanning; Carboxymethylcellulose Sodium; Drug Compounding; Drug Liberation; Drug Stability; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Micelles; Microscopy, Electron, Scanning; Nifedipine; Particle Size; Polyethylene Glycols; Polymers; Solubility; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction	2020
Self-assembly in aqueous solution of amphiphilic graft copolymers from oxidized carboxymethylcellulose. Carbohydrate polymers, 2015, Jun-25, Volume: 124 A series of oxidized carboxymethylcellulose-graft-poly(ethylene glycol)-dodecylamine (OCMC-g-PEG-DDA) was prepared by using an appositely prepared PEG with terminal amino groups and different amounts of DDA. The nanoaggregates formed in aqueous solution were characterized by surface tension measurements, fluorescence spectroscopy, dynamic light scattering (DLS) and scanning electron microscopies (SEM and TEM). The micelles showed narrow hydrodynamic size distributions and diameters varying from 163 to 193nm depending on the ratio of DDA to PEG chains. The DDA content in the graft copolymers also affected the core-shell interfacial compactness. Topics: Amines; Carboxymethylcellulose Sodium; Micelles; Microscopy, Electron; Polyethylene Glycols; Spectrometry, Fluorescence; Surface Tension; Surface-Active Agents; Water	2015

Article

Year

Dissolution of amorphous nifedipine from micelle-forming carboxymethylcellulose derivatives.

Carbohydrate polymers, 2020, Nov-01, Volume: 247

We show that a novel amphiphilic graft copolymer combining the biodegradability and biocompatibility of oxidized carboxymethylcellulose (CMC) with that of hydrophilic poly(ethylene glycol) (PEG), and hydrophobic dodecylamine (DDA), improves the solubility and dissolution performance of nifedipine (NIF), considered as a model hydrophobic drug. The hydrophobic components of the graft copolymer have the multiple effect of favouring micelle formation and loading. At the same time, the interaction between the hydrophobic core and NIF has the secondary effect to suppress drug crystallization, favouring its dissolution, and to increase photostability. Oxidized CMC-g-PEG-DDA micelles reached values of drug concentration, loading capacity and encapsulation efficiency as high as 340 μg mL

Topics: Amines; Biocompatible Materials; Calorimetry, Differential Scanning; Carboxymethylcellulose Sodium; Drug Compounding; Drug Liberation; Drug Stability; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Micelles; Microscopy, Electron, Scanning; Nifedipine; Particle Size; Polyethylene Glycols; Polymers; Solubility; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction

2020

Self-assembly in aqueous solution of amphiphilic graft copolymers from oxidized carboxymethylcellulose.

Carbohydrate polymers, 2015, Jun-25, Volume: 124

A series of oxidized carboxymethylcellulose-graft-poly(ethylene glycol)-dodecylamine (OCMC-g-PEG-DDA) was prepared by using an appositely prepared PEG with terminal amino groups and different amounts of DDA. The nanoaggregates formed in aqueous solution were characterized by surface tension measurements, fluorescence spectroscopy, dynamic light scattering (DLS) and scanning electron microscopies (SEM and TEM). The micelles showed narrow hydrodynamic size distributions and diameters varying from 163 to 193nm depending on the ratio of DDA to PEG chains. The DDA content in the graft copolymers also affected the core-shell interfacial compactness.

Topics: Amines; Carboxymethylcellulose Sodium; Micelles; Microscopy, Electron; Polyethylene Glycols; Spectrometry, Fluorescence; Surface Tension; Surface-Active Agents; Water

2015