orabase and arginyl-glycyl-aspartic-acid

orabase has been researched along with arginyl-glycyl-aspartic-acid* in 1 studies

Other Studies

1 other study(ies) available for orabase and arginyl-glycyl-aspartic-acid

Article	Year
Design and Development of Polysaccharide-Doxorubicin-Peptide Bioconjugates for Dual Synergistic Effects of Integrin-Targeted and Cell-Penetrating Peptides for Cancer Chemotherapy. Bioconjugate chemistry, 2018, 06-20, Volume: 29, Issue:6 Polymer-drug conjugation is an attractive approach for target delivering insoluble and highly toxic drugs to tumor sites to overcome the side-effects caused by cancer chemotherapy. In this study we designed and synthesized novel polymer-drug-peptide conjugates for improved specificity on targeting cancer cells. Chemically modified polysaccharide, carboxymethylcellulose (CMC), was conjugated with doxorubicin (DOX) anticancer drug by amide bonds and dually biofunctionalized with integrin-target receptor tripeptide (RGD) and l-arginine (R) as cell-penetrating amino acid for synergistic targeting and enhancing internalization by cancer cells. These bioconjugates were tested as prodrugs against bone, breast, and brain cancer cell lines (SAOS, MCF7, and U87) and a normal cell line (HEK 293T, reference). The physicochemical characterization showed the formation of amide bonds between carboxylates (-RCOO Topics: Animals; Antibiotics, Antineoplastic; Arginine; Carboxymethylcellulose Sodium; Cell Line, Tumor; Cell-Penetrating Peptides; Chickens; Doxorubicin; Drug Carriers; Drug Delivery Systems; HEK293 Cells; Humans; Integrins; Neoplasms; Oligopeptides	2018

Article

Year

Design and Development of Polysaccharide-Doxorubicin-Peptide Bioconjugates for Dual Synergistic Effects of Integrin-Targeted and Cell-Penetrating Peptides for Cancer Chemotherapy.

Bioconjugate chemistry, 2018, 06-20, Volume: 29, Issue:6

Polymer-drug conjugation is an attractive approach for target delivering insoluble and highly toxic drugs to tumor sites to overcome the side-effects caused by cancer chemotherapy. In this study we designed and synthesized novel polymer-drug-peptide conjugates for improved specificity on targeting cancer cells. Chemically modified polysaccharide, carboxymethylcellulose (CMC), was conjugated with doxorubicin (DOX) anticancer drug by amide bonds and dually biofunctionalized with integrin-target receptor tripeptide (RGD) and l-arginine (R) as cell-penetrating amino acid for synergistic targeting and enhancing internalization by cancer cells. These bioconjugates were tested as prodrugs against bone, breast, and brain cancer cell lines (SAOS, MCF7, and U87) and a normal cell line (HEK 293T, reference). The physicochemical characterization showed the formation of amide bonds between carboxylates (-RCOO

Topics: Animals; Antibiotics, Antineoplastic; Arginine; Carboxymethylcellulose Sodium; Cell Line, Tumor; Cell-Penetrating Peptides; Chickens; Doxorubicin; Drug Carriers; Drug Delivery Systems; HEK293 Cells; Humans; Integrins; Neoplasms; Oligopeptides

2018