orabase has been researched along with 2-norbornene* in 2 studies
2 other study(ies) available for orabase and 2-norbornene
| Article | Year |
|---|---|
Reduction-responsive and bioorthogonal carboxymethyl cellulose based soft hydrogels cross-linked via IEDDA click chemistry for cancer therapy application.
In this work, novel biocompatible and reduction-responsive soft hydrogels were formulated from norbornene (Nb)-functionalized carboxymethyl cellulose (CMCNb). To cross-link the CMC-Nb via a highly bioorthogonal inverse electron demand Diels-Alder (IEDDA) reaction, we employed a water-soluble and reduction-responsive diselenide-based cross-linker possessing two terminal tetrazine (Tz) groups with varying molar concentrations (Nb/Tz molar ratios of 10/10, 10/05, and 10/2.5). The N Topics: Carboxymethylcellulose Sodium; Click Chemistry; Doxorubicin; Electrons; Glutathione; Hydrogels; Neoplasms; Norbornanes; Water | 2022 |
Synthesis and Spatiotemporal Modification of Biocompatible and Stimuli-Responsive Carboxymethyl Cellulose Hydrogels Using Thiol-Norbornene Chemistry.
Carboxymethyl cellulose (CMC) is functionalized with norbornene groups to undergo thiol-norbornene cross-linking reactions. Hydrogels synthesized from a single norbornene-modified carboxymethyl cellulose (NorCMC) via a light-initiated thiol-ene cross-linking reaction with a variety of dithiol cross-linkers yield hydrogels with a tunable compression modulus ranging from 1.7 to 103 kPa. Additionally, thermoresponsiveness is spatiotemporally imparted to NorCMC hydrogels by photopatterning a dithiol-terminated poly(N-isopropyl acrylamide) cross-linker, enabling swelling and topological control of the hydrogels as a function of incubation temperature. NorCMC hydrogels are cytocompatible as the viability of encapsulated human mesenchymal stem cells (hMSCs) is greater than 85% after 21 d while using a variety of cross-linkers. Moreover, hMSCs can remodel, adhere, and spread in the NorCMC matrix cross-linked with a matrix metalloproteinase-degradable peptide, further demonstrating the utility of these materials as a tunable biomaterial. Topics: Acrylic Resins; Biocompatible Materials; Carboxymethylcellulose Sodium; Cells, Cultured; Cross-Linking Reagents; Humans; Hydrogels; Mesenchymal Stem Cells; Norbornanes; Sulfhydryl Compounds; Tissue Engineering; Tissue Scaffolds | 2017 |