opc 4392 has been researched along with carbostyril in 13 studies
| Studies (opc 4392) | Trials (opc 4392) | Recent Studies (post-2010) (opc 4392) | Studies (carbostyril) | Trials (carbostyril) | Recent Studies (post-2010) (carbostyril) |
|---|---|---|---|---|---|
| 16 | 1 | 0 | 12,855 | 1,323 | 5,611 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (46.15) | 18.7374 |
| 1990's | 4 (30.77) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kikuchi, T; Nakata, Y; Segawa, T; Zhang, X | 1 |
| Momiyama, T; Sasa, M; Takaori, S | 1 |
| Hirata, Y; Kiuchi, K; Minami, M; Nagatsu, T | 1 |
| Fukuyama, Y; Ishigooka, J; Ishii, Y; Miura, S; Murasaki, M; Takahashi, A | 1 |
| Bochnik, J; Demisch, L; Gerbaldo, H; Lehmann, CO | 1 |
| Banno, K; Fujioka, T; Hiyama, T; Kikuchi, T; Nakagawa, K; Oshiro, Y | 1 |
| Hiyama, T; Kikuchi, T; Suzuki, S; Tsutsui, M; Yamada, K; Yasuda, Y | 1 |
| Ohno, Y; Sasa, M; Takaori, S | 1 |
| Bailey, P; Castro, JO; Crocq, MA; Duval, F; Lataste, X; Macher, JP; Mokrani, MC | 1 |
| Fujikawa, M; Furukawa, T; Inoue, T; Nagashima, M; Yamada, K | 1 |
| Burris, KD; Kikuchi, T; Miwa, T; Mori, T; Stark, A; Tadori, Y; Tottori, K | 1 |
| Chen, R; Johnson, JL; Jordan, S; Kambayashi, J; Kikuchi, T; Kitagawa, H; McQuade, R; Regardie, K; Tadori, Y | 1 |
| Forbes, RA; Kikuchi, T; Kitagawa, H; McQuade, RD; Stark, A; Tadori, Y | 1 |
1 trial(s) available for opc 4392 and carbostyril
| Article | Year |
|---|---|
Neuroendocrine profile of SDZ HDC-912 and OPC-4392, two new atypical antipsychotic drugs, in schizophrenic patients.
Topics: Adult; Amisulpride; Antipsychotic Agents; Apomorphine; Dopamine Agonists; Ergolines; Female; Growth Hormone; Humans; Male; Neurosecretory Systems; Piperazines; Prolactin; Quinolones; Schizophrenia; Sulpiride | 1993 |
12 other study(ies) available for opc 4392 and carbostyril
| Article | Year |
|---|---|
Interactions of 7-[3-(4-[2,3-dimethylphenyl]piperazinyl)-propoxy]-2(1H)-quinolinone binding in rat striatum: effects of lesions.
Topics: Animals; Benzazepines; Binding, Competitive; Corpus Striatum; Dopamine Agents; Hydroxydopamines; In Vitro Techniques; Kainic Acid; Male; Medial Forebrain Bundle; Oxidopamine; Piperazines; Quinolones; Rats; Rats, Inbred Strains; Spiperone | 1990 |
D-2 receptor-mediated inhibition by a substituted quinolinone derivative, 7-[3-(4-(2,3-dimethylphenyl)piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), of dopaminergic neurons in the ventral tegmental area.
Topics: Animals; Benzazepines; Domperidone; Dopamine; Dopamine Agents; Electric Stimulation; Male; Neurons; Nucleus Accumbens; Piperazines; Quinolones; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Tegmentum Mesencephali | 1990 |
Effect of 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)- 2(1H)-quinolinone (OPC-4392), a newly synthesized agonist for presynaptic dopamine D2 receptor, on tyrosine hydroxylation in rat striatal slices.
Topics: Animals; Corpus Striatum; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Hydroxylation; In Vitro Techniques; Male; Piperazines; Quinolines; Quinolones; Rats; Receptors, Dopamine; Receptors, Neurotransmitter; Tyrosine 3-Monooxygenase | 1988 |
Phase 1 study of a new antipsychotic drug, OPC-4392.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Drug Evaluation, Preclinical; Humans; Male; Piperazines; Prolactin; Quinolones | 1988 |
The effect of OPC-4392, a partial dopamine receptor agonist on negative symptoms: results of an open study.
Topics: Adult; Dopamine Agents; Hallucinations; Humans; Male; Middle Aged; Piperazines; Psychiatric Status Rating Scales; Quinolones; Schizophrenia; Schizophrenic Psychology | 1988 |
Studies on 2(1H)-quinolinone derivatives as neuroleptic agents I. Synthesis and biological activities of (4-phenyl-1-piperazinyl)-propoxy-2(1H)-quinolinone derivatives.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chemical Phenomena; Chemistry; Male; Mice; Mice, Inbred ICR; Piperazines; Quinolones; Structure-Activity Relationship | 1988 |
7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist.
Topics: Animals; Apomorphine; Brain; Corpus Striatum; Diencephalon; Dihydroxyphenylalanine; Frontal Lobe; Hydroxydopamines; Kainic Acid; Kinetics; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxidopamine; Piperazines; Piperidines; Quinolines; Quinolones; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Telencephalon | 1988 |
Presynaptic inhibition of excitatory input from the substantia nigra to caudate nucleus neurons by a substituted quinolinone derivative, 7-[3-(4-(2,3-dimethylphenyl)piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392).
Topics: Action Potentials; Animals; Bromocriptine; Cats; Caudate Nucleus; Domperidone; Dopamine; Electric Stimulation; Neural Pathways; Neurons; Piperazines; Quinolines; Quinolones; Sodium Glutamate; Substantia Nigra | 1988 |
Partial agonistic effects of OPC-14597, a potential antipsychotic agent, on yawning behavior in rats.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Azepines; Dopamine Agonists; Drug Synergism; Male; Oxidopamine; Piperazines; Piperidines; Quinolones; Rats; Rats, Wistar; Receptors, Dopamine; Stereotyped Behavior; Sympathectomy, Chemical; Yawning | 1996 |
Aripiprazole's low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; DNA, Complementary; Dopamine; Dopamine Agonists; Dopamine Antagonists; Haloperidol; Humans; Lisuride; Piperazines; Piperidines; Quinolones; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Risperidone; Transfection; Tritium | 2005 |
In vitro functional characteristics of dopamine D2 receptor partial agonists in second and third messenger-based assays of cloned human dopamine D2Long receptor signalling.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Calcium Signaling; CHO Cells; Cloning, Molecular; Cricetinae; Cricetulus; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Immunoblotting; Lisuride; MAP Kinase Signaling System; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Phosphorylation; Piperazines; Piperidines; Quinolones; Raclopride; Receptors, Dopamine D2; Schizophrenia; Time Factors; Transfection | 2007 |
Differences in agonist/antagonist properties at human dopamine D(2) receptors between aripiprazole, bifeprunox and SDZ 208-912.
Topics: Animals; Aripiprazole; Benzoxazoles; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Ergolines; Humans; Piperazines; Quinolones; Radioligand Assay; Receptors, Dopamine D2; Schizophrenia | 2007 |