opc 21268 has been researched along with pituitrin in 28 studies
| Studies (opc 21268) | Trials (opc 21268) | Recent Studies (post-2010) (opc 21268) | Studies (pituitrin) | Trials (pituitrin) | Recent Studies (post-2010) (pituitrin) |
|---|---|---|---|---|---|
| 133 | 3 | 6 | 22,137 | 594 | 2,101 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (67.86) | 18.2507 |
| 2000's | 9 (32.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hirata, Y; Kohmoto, O; Matsui, H; Serizawa, T | 1 |
| Asahina, Y; Fukuma, T; Izumi, N; Liu, JH; Marumo, F; Sakaj, Y; Sato, C; Takano, T; Uchihara, M; Yauchi, T | 1 |
| Chiba, S; Tsukada, M | 1 |
| Hirai, A; Uchida, D; Yoshida, S | 1 |
| Abe, K; Funyu, T; Inoue, M; Kimura, T; Ohta, M; Ota, K; Sato, K; Shoji, M; Yamamoto, T | 1 |
| Kanno, Y; Okada, H; Saruta, T; Suzuki, H; Yamamura, Y | 1 |
| Delisee, C; Dol, F; Garcia, C; Herbert, JM; Le Fur, G; Maffrand, JP; Marty, E; Raufaste, D; Schaeffer, P; Serradeil-Le Gal, C | 1 |
| Akishita, M; Liang, J; Orimo, H; Ouchi, Y; Toba, K | 1 |
| Abe, K; Abe, T; Obinata, M; Takahashi, N; Takeuchi, K; Tsutsumi, E; Yanai, N | 1 |
| Crofton, JT; Ota, M; Share, L | 1 |
| Fujihara, H; Ko, Y; Miyamoto, G; Odomi, M; Ohnishi, A; Okada, K | 1 |
| Fujisawa, G; Ishikawa, S; Okada, K; Saito, T; Tsuboi, Y | 1 |
| Harada, S; Hirooka, Y; Imaizumi, T; Masaki, H; Momohara, M; Takeshita, A | 1 |
| Andersen, LF; Atke, A; Barth, T; Hauzerova, L; Vilhardt, H | 1 |
| Hashimoto, M; Hayakawa, N; Makino, H; Mimura, Y; Ogawa, N; Ogura, T; Otsuka, F; Yamauchi, T | 1 |
| Kawano, Y; Matsuoka, H; Nishikimi, T; Omae, T; Takishita, S | 1 |
| Bie, P; Christensen, P; Grove, L | 1 |
| Fujita, H; Iwao, H; Miura, K; Omura, T; Takeuchi, K; Yamagishi, H; Yoshikawa, J; Yoshiyama, M | 1 |
| Narimiya, N; Odagiri, M; Ohnishi, A; Sugimoto, I; Tanaka, T | 1 |
| Haneda, T; Kikuchi, K; Miyata, S; Nakamura, Y; Osaki, J | 1 |
| Ludwig, M; Onaka, T; Yagi, K | 1 |
| Ferguson, JW; Hayes, PC; Newby, DE; Therapondos, G | 1 |
| Brown, CH; Leng, G; Ludwig, M | 1 |
| Chu, CP; Ishida, Y; Kannan, H; Kato, K; Nishimori, T; Nose, H | 1 |
| Akamatsu, S; Hirade, K; Ishisaki, A; Kanno, Y; Kato, K; Kozawa, O; Matsuno, H; Nakajima, K; Oiso, Y; Shu, E; Suga, H; Takai, S; Tanabe, K | 1 |
| Chu, CP; Jin, QH; Kannan, H; Kato, K; Oiso, Y; Qiu, DL; Yu, NS | 1 |
| Carlin, RW; Hagedorn, TM; Schultz, BD | 1 |
| Cowley, AW; O'Connor, PM | 1 |
2 review(s) available for opc 21268 and pituitrin
| Article | Year |
|---|---|
[Vasopressin (ADH)].
Topics: Amino Acid Sequence; Animals; Antidiuretic Hormone Receptor Antagonists; Base Sequence; Blood Pressure; Cloning, Molecular; Cyclic AMP; Humans; Molecular Sequence Data; Piperidines; Quinolones; Receptors, Vasopressin; Vasoconstriction; Vasopressins | 1992 |
Therapeutic role of vasopressin receptor antagonism in patients with liver cirrhosis.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Azepines; Benzamides; Benzazepines; Controlled Clinical Trials as Topic; Diuretics; Heart Failure; Homeostasis; Humans; Inappropriate ADH Syndrome; Liver Cirrhosis; Models, Animal; Morpholines; Piperidines; Pyrroles; Quinolones; Rats; Spiro Compounds; Vasopressins | 2003 |
2 trial(s) available for opc 21268 and pituitrin
| Article | Year |
|---|---|
Pharmacokinetics, safety, and pharmacologic effects of OPC-21268, a nonpeptide orally active vasopressin V1 receptor antagonist, in humans.
Topics: Administration, Oral; Adult; Antidiuretic Hormone Receptor Antagonists; Drug Administration Schedule; Humans; Japan; Male; Piperidines; Quinolones; Single-Blind Method; Vasopressins | 1993 |
The role of vasopressin in essential hypertension. Plasma levels and effects of the V1 receptor antagonist OPC-21268 during different dietary sodium intakes.
Topics: Adult; Aged; Antidiuretic Hormone Receptor Antagonists; Baroreflex; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Piperidines; Quinolones; Sodium, Dietary; Vasopressins | 1997 |
24 other study(ies) available for opc 21268 and pituitrin
| Article | Year |
|---|---|
Effects of a nonpeptide vasopressin antagonist (OPC-21268) on cytosolic Ca2+ concentration in vascular and cardiac myocytes.
Topics: Animals; Arginine Vasopressin; Calcium; Cytosol; Muscle, Smooth, Vascular; Myocardium; Osmolar Concentration; Piperidines; Quinolones; Vasopressins | 1992 |
V1-receptor mediated GSH efflux by vasopressin from rat hepatocytes.
Topics: Angiotensin Receptor Antagonists; Animals; Biological Transport; Cells, Cultured; Glutathione; Glycogen; Liver; Male; Piperidines; Quinolones; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Receptors, Vasopressin; Vasopressins | 1992 |
Blocking effects of OPC-21268 and OPC-31260 (vasopressin V1- and V2-receptor antagonists) on vasopressin-induced constrictions in isolated, perfused dog femoral arteries.
Topics: Angiotensin Receptor Antagonists; Animals; Benzazepines; Dogs; Dose-Response Relationship, Drug; Femoral Artery; Norepinephrine; Piperidines; Quinolones; Receptors, Vasopressin; Vasoconstriction; Vasopressins | 1992 |
Effects of V1- and V2-vasopressin (AVP) antagonists on the pressor, AVP and atrial natriuretic peptide responses to a hypertonic saline infusion in conscious anephric rats.
Topics: Animals; Atrial Natriuretic Factor; Benzazepines; Blood Pressure; Heart Rate; Hemodynamics; Kidney; Male; Nephrectomy; Neurons, Afferent; Osmolar Concentration; Piperidines; Plasma Volume; Quinolones; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Saline Solution, Hypertonic; Vasopressins | 1995 |
Chronic and selective vasopressin blockade in spontaneously hypertensive rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Blood Pressure; Hypertension; Male; Osmolar Concentration; Piperidines; Quinolones; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Vasopressin; Urine; Vasopressins | 1994 |
Effect of SR-49059, a vasopressin V1a antagonist, on human vascular smooth muscle cells.
Topics: Aorta; Arginine Vasopressin; Calcium; Cell Division; Cell Membrane; Cells, Cultured; Deamino Arginine Vasopressin; Dose-Response Relationship, Drug; Humans; Indoles; Iodine Radioisotopes; Kinetics; Muscle, Smooth, Vascular; Oxytocin; Piperidines; Pyrrolidines; Quinolones; Radioligand Assay; Receptors, Vasopressin; Vasopressins | 1995 |
Role of central vasopressin in cardiovascular regulation: effect of dehydration and sex.
Topics: Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Dehydration; Female; Heart Rate; Injections, Intraventricular; Male; Piperidines; Quinolones; Rats; Rats, Brattleboro; Sex Factors; Vasopressins | 1994 |
Different cellular mechanisms of vasopressin receptor V1 and V2 subtype in vasopressin-induced adenosine 3', 5'-monophosphate formation in an immortalized renal tubule cell line, TKC2.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Antigens, Polyomavirus Transforming; Benzazepines; Calcium; Cell Line, Transformed; Cyclic AMP; Dinoprostone; Indomethacin; Kidney Tubules; Mice; Mice, Transgenic; Piperidines; Quinolones; Receptors, Vasopressin; Vasopressins | 1994 |
Role of vasopressin, the renin-angiotensin system and sex in Dahl salt-sensitive hypertension.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Blood Pressure; Captopril; Circadian Rhythm; Diet; Female; Hypertension; Male; Piperidines; Quinolones; Rats; Rats, Mutant Strains; Renin-Angiotensin System; Sex Characteristics; Sodium Chloride; Vasopressins | 1993 |
Nonpeptide vasopressin antagonist and its application in the correction of experimental hyponatremia in rats.
Topics: Animals; Benzazepines; Cells, Cultured; Hyponatremia; Inappropriate ADH Syndrome; Kidney Tubules, Collecting; Muscle, Smooth, Vascular; Piperidines; Quinolones; Rats; Rats, Brattleboro; Rats, Sprague-Dawley; Vasopressins | 1993 |
Effects of a novel orally effective V1-receptor antagonist, OPC-21268, on AVP-induced sympathoinhibition.
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Blood Pressure; Heart Rate; Injections, Intravenous; Kidney; Male; Neural Inhibition; Phenylephrine; Piperidines; Quinolones; Rabbits; Sympathetic Nervous System; Vasopressins | 1993 |
Effects of the non-peptide inhibitor OPC-21268 on oxytocin and vasopressin stimulation of rat and human myometrium.
Topics: Anesthesia; Animals; Antidiuretic Hormone Receptor Antagonists; Cell Membrane; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; In Vitro Techniques; Myometrium; Oxytocin; Piperidines; Pregnancy; Quinolones; Rats; Receptors, Oxytocin; Receptors, Vasopressin; Sensitivity and Specificity; Stimulation, Chemical; Uterine Contraction; Vasopressins | 1995 |
In vitro macro- and microautoradiographic localization of V1 and V2 receptors in the rat kidney using OPC-21268 and OPC-31260.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Autoradiography; Benzazepines; In Vitro Techniques; Kidney; Ligands; Male; Piperidines; Quinolones; Rats; Rats, Wistar; Receptors, Vasopressin; Tissue Distribution; Tritium; Vasopressins | 1997 |
Effects of receptor blockade on metabolism and renal actions of vasopressin in conscious dogs.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Dimethyl Sulfoxide; Dogs; Female; Glomerular Filtration Rate; Hemodynamics; Hormones; Kidney; Natriuresis; Piperidines; Quinolones; Solvents; Vasopressins | 1998 |
The effect of vasopressin V1- and V2-receptor antagonists on hemodynamics in early and late phase after myocardial infarction in rats.
Topics: Administration, Oral; Animals; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Heart Ventricles; Hemodynamics; Male; Myocardial Infarction; Organ Size; Piperidines; Quinolones; Rats; Rats, Wistar; Time Factors; Vasopressins; Ventricular Function, Left | 1998 |
Protective effect of a vasopressin-1 selective antagonist, OPC-21268, against ethanol-induced damage of the rat gastric wall.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Ethanol; Gastric Mucosa; Male; Microcirculation; Piperidines; Quinolones; Rats; Stomach Ulcer; Vasopressins | 1999 |
Hypertrophic growth of cultured neonatal rat heart cells mediated by vasopressin V(1A) receptor.
Topics: Animals; Animals, Newborn; Antidiuretic Hormone Receptor Antagonists; Benzazepines; Blotting, Northern; Calcium; Cardiomegaly; Cells, Cultured; Culture Media; DNA; Kinetics; Myocardium; Piperidines; Protein Biosynthesis; Protein Kinase C; Proteins; Proto-Oncogene Proteins c-fos; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; RNA, Messenger; Second Messenger Systems; Vasopressins | 2000 |
Vasopressin regulation of noradrenaline release within the supraoptic nucleus.
Topics: Antidiuretic Hormone Receptor Antagonists; Chromatography, High Pressure Liquid; Electrochemistry; Neurons; Norepinephrine; Piperidines; Potassium; Quinolones; Supraoptic Nucleus; Vasopressins | 2000 |
Temporal dissociation of the feedback effects of dendritically co-released peptides on rhythmogenesis in vasopressin cells.
Topics: Action Potentials; Animals; Antidiuretic Hormone Receptor Antagonists; Dendrites; Dynorphins; Feedback, Physiological; Female; Naltrexone; Narcotic Antagonists; Periodicity; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Supraoptic Nucleus; Vasopressins | 2004 |
Regional differences in the expression of Fos-like immunoreactivity after central salt loading in conscious rats: modulation by endogenous vasopressin and role of the area postrema.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Area Postrema; Blood Pressure; Cell Count; Consciousness; Dose-Response Relationship, Drug; Gene Expression; Heart Rate; Hypothalamus; Immunohistochemistry; Ion-Selective Electrodes; Male; Piperidines; Proto-Oncogene Proteins c-fos; Quinolones; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Salts; Sodium; Solitary Nucleus; Time Factors; Vasopressins | 2004 |
Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.
Topics: Animals; Aorta; Blotting, Western; Cell Line; Chromones; Enzyme Inhibitors; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Imidazoles; MAP Kinase Signaling System; Molecular Chaperones; Morpholines; Muscle, Smooth; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyridines; Quinolones; Rats; Time Factors; Vasopressins | 2005 |
Enhanced cardiovascular alteration and Fos expression induced by central salt loading in a conscious rat transgenic for the metallothionein-vasopressin fusion gene.
Topics: Animals; Animals, Genetically Modified; Antidiuretic Hormone Receptor Antagonists; Arginine; Brain; Cardiovascular System; Consciousness; Immunohistochemistry; Injections, Intraventricular; Male; Metallothionein; Oncogene Proteins v-fos; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Recombinant Fusion Proteins; Saline Solution, Hypertonic; Sodium Chloride; Vasopressins | 2005 |
Oxytocin and vasopressin stimulate anion secretion by human and porcine vas deferens epithelia.
Topics: Alkaloids; Animals; Anions; Antidiuretic Hormone Receptor Antagonists; Benzophenanthridines; Cell Line; Cyclic AMP; Electrophysiology; Epithelial Cells; Humans; Ion Transport; Male; Oxytocin; Piperidines; Quinolones; Receptors, Oxytocin; Receptors, Vasopressin; Reverse Transcriptase Polymerase Chain Reaction; Swine; Vas Deferens; Vasopressins | 2007 |
Vasopressin-induced nitric oxide production in rat inner medullary collecting duct is dependent on V2 receptor activation of the phosphoinositide pathway.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Benzazepines; Calcium; Calcium-Transporting ATPases; Cyclic AMP-Dependent Protein Kinases; Kidney Medulla; Kidney Tubules, Collecting; Male; Nitric Oxide; Phosphatidylinositols; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Vasopressin; Signal Transduction; Spectrometry, Fluorescence; Type C Phospholipases; Vasopressins | 2007 |