ono 6818 has been researched along with pyrimidinones in 9 studies
| Studies (ono 6818) | Trials (ono 6818) | Recent Studies (post-2010) (ono 6818) | Studies (pyrimidinones) | Trials (pyrimidinones) | Recent Studies (post-2010) (pyrimidinones) |
|---|---|---|---|---|---|
| 12 | 0 | 2 | 6,059 | 604 | 2,692 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (88.89) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheronis, JC; Gyorkos, A; Hirota, Y; Horiuchi, T; Imanishi, H; Kawabata, K; Matsuoka, S; Nakai, H; Odagaki, Y; Ohmoto, K; Sekioka, T; Spruce, LW; Toda, M; Wieczorek, M; Yamamoto, T | 1 |
| Imawaka, H; Kawabata, K; Kijima, H; Kitagawa, K; Nakai, H; Ohmoto, K; Okuma, M; Sakata, A; Sekioka, T; Tanaka, K; Toda, M; Yamamoto, S; Yamamoto, T | 1 |
| Hirasawa, N; Honda, M; Okada, M; Ozawa, M; Sano, K; Shirota, H; Tagami, H; Tamura, G; Terui, T | 1 |
| Ishibashi, M; Kuraki, T; Shiraishi, M; Takayama, M; Yoshida, M | 1 |
| Trifilieff, A | 1 |
| Enomoto, Y; Hiramatsu, Y; Homma, S; Jikuya, T; Sakakibara, Y; Sato, Y; Yoshimura, Y | 1 |
| Fujita, T; Hirota, Y; Katsube, N; Suzuki, M; Yamaguchi, K | 2 |
| Churg, A; Ekholm, K; Falk-Håkansson, H; Gränse, M; Jungar, C; Kozma, V; Lal, H; Lindahl, M; Ottosson, T; Sanfridson, A; Stevens, T; Wright, JL | 1 |
1 review(s) available for ono 6818 and pyrimidinones
| Article | Year |
|---|---|
ONO-6818 Cortech/Ono.
Topics: Animals; Anti-Inflammatory Agents; Clinical Trials, Phase I as Topic; Enzyme Inhibitors; Humans; Leukocyte Elastase; Oxadiazoles; Pyrimidinones | 2002 |
8 other study(ies) available for ono 6818 and pyrimidinones
| Article | Year |
|---|---|
Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase.
Topics: Administration, Oral; Animals; Crystallography, X-Ray; Dogs; Drug Design; Enzyme Inhibitors; Haplorhini; Humans; Leukocyte Elastase; Oxadiazoles; Pyrimidinones; Rats; Structure-Activity Relationship | 2000 |
Design and synthesis of new orally active inhibitors of human neutrophil elastase.
Topics: Administration, Oral; Animals; Cricetinae; Drug Design; Drug Stability; Enzyme Inhibitors; Humans; Hydrolysis; Leukocyte Elastase; Oxadiazoles; Peptides; Pyrimidinones | 2001 |
Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells.
Topics: Animals; Cells, Cultured; Chromones; Dermatitis, Atopic; Disease Models, Animal; Ear; Edema; Enzyme Inhibitors; Eosinophils; Hypersensitivity; Immunosuppressive Agents; Leukotriene Antagonists; Male; Mice; Mice, Inbred BALB C; Neutrophils; Ovalbumin; Oxadiazoles; Pyrimidinones; Skin; Tacrolimus; Th1 Cells; Th2 Cells | 2001 |
A novel oral neutrophil elastase inhibitor (ONO-6818) inhibits human neutrophil elastase-induced emphysema in rats.
Topics: Administration, Oral; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Emphysema; Functional Residual Capacity; Humans; Leukocyte Count; Leukocyte Elastase; Lung Compliance; Lung Volume Measurements; Male; Neutrophils; Oxadiazoles; Pyrimidinones; Rats; Rats, Wistar; Respiratory Mechanics; Sputum | 2002 |
ONO-6818, a novel, potent neutrophil elastase inhibitor, reduces inflammatory mediators during simulated extracorporeal circulation.
Topics: Actins; Cardiopulmonary Bypass; CD11b Antigen; Complement Membrane Attack Complex; Extracorporeal Circulation; Flow Cytometry; Humans; Immunoenzyme Techniques; Interleukin-8; L-Selectin; Leukocyte Elastase; Models, Biological; Oxadiazoles; Pyrimidinones | 2003 |
Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters.
Topics: Acetic Acid; Animals; Colitis; Cricetinae; Hemoglobins; Leukocyte Elastase; Male; Mesocricetus; Oxadiazoles; Peroxidase; Pyrimidinones; Serpins | 2004 |
Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus).
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cricetinae; Disease Models, Animal; Leukocyte Elastase; Male; Mesocricetus; Oxadiazoles; Prednisolone; Pyrimidinones; Random Allocation; Trinitrobenzenesulfonic Acid | 2005 |
AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Dogs; Dose-Response Relationship, Drug; Emphysema; Female; Glycine; Guinea Pigs; Humans; Kinetics; Leukocyte Elastase; Mice; Mice, Inbred BALB C; Oxadiazoles; Pneumonia; Protein Binding; Pyridones; Pyrimidinones; Rats; Serine Proteinase Inhibitors; Species Specificity; Substrate Specificity; Sulfonamides; Sulfones; Swine; Tobacco Smoke Pollution | 2011 |