ono 1078 has been researched along with leukotriene d4 in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (43.18) | 18.2507 |
| 2000's | 21 (47.73) | 29.6817 |
| 2010's | 3 (6.82) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| Authors | Studies |
|---|---|
| Baronissi, G; Biagioli, M; Cassiano, C; Catalanotti, B; Conflitti, P; De Luca, P; Fiorillo, B; Fiorucci, S; Limongelli, V; Marchianò, S; Rapacciuolo, P; Roselli, R; Sepe, V; Zampella, A | 1 |
| Bochnowicz, S; Underwood, DC | 1 |
| Hikasa, Y; Hori, K; Nishikawa, M; Shimoyama, T; Tanida, N | 1 |
| Horiba, M; Kohno, S; Nabe, T; Ohata, K; Saeki, Y; Tanpo, T; Yamamura, H | 1 |
| Kurosawa, M; Miyachi, Y; Tsukagoshi, H; Yodonawa, S | 1 |
| Ichinose, M; Ishikawa, J; Kageyama, N; Miura, M; Sasaki, Y; Shirato, K; Tomaki, M; Yamauchi, H | 1 |
| Hosokawa, M; Nakamura, H; Okuma, M; Sakai, M; Taniguchi, T; Tominaga, M; Tsukada, H; Ueda, S | 1 |
| Hay, DW; Newsholme, SJ; Osborn, RR; Torphy, TJ; Underwood, DC | 1 |
| Allen, E; Brocks, DR; Dennis, MJ; Doyle, E; Georgiou, P; Stelman, G; Upward, JW; Wyld, P | 1 |
| Barnes, NC; Compton, CH; Dennis, M; Georgiou, P; Howland, K; O'Shaughnessy, TC | 1 |
| Fujita, M; Kawabata, K; Nakagawa, N; Ohno, H; Takeda, H; Yonetomi, Y | 1 |
| Khawaja, AM; Liu, YC; Rogers, DF | 1 |
| Asakura, K; Kataura, A; Narita, S; Shirasaki, H | 1 |
| Ciocca, V; Hay, DW; Leonard, TB; Luttmann, MA; Panettieri, RA; Tan, EM | 1 |
| Aikou, T; Akiyama, S; Chen, ZS; Furukawa, T; Haraguchi, M; Kitazono, M; Nagayama, S; Niwa, K; Sumizawa, T; Takebayashi, Y; Tani, A; Yamada, K | 1 |
| Hino, T; Kawashima, Y; Serigano, T; Takeuchi, H; Yamamoto, H | 1 |
| Antognoli, GW; Chambers, RJ; Cheng, JB; Marfat, A; Pillar, JS; Shirley, JT; Watson, JW | 1 |
| Abe, M; Hugli, TE; Kamiya, H; Katsuragi, T; Kodani, M; Sakata, N; Takano, Y | 1 |
| Hisamatsu, K; Nakajima, M | 1 |
| Kuwahara, M; Saegusa, S; Tsubone, H | 1 |
| Kawano, T; Kohno, S; Matsuse, H; Mitsuta, K; Obase, Y; Shimoda, T; Tomari, SY | 1 |
| Adachi, Y; Arai, S; Furukawa, M; Ikehara, S; Ogura, M; Tada, N; Yamashita, T | 1 |
| Capra, V; Nicosia, S; Panigalli, T; Ravasi, S; Rovati, GE | 1 |
| Mizutani, N | 1 |
| Furukawa, S; Hasegawa, S; Ichiyama, T; Matsubara, T; Terai, K; Umeda, M | 1 |
| Fujiu, T; Kato, M; Kimura, H; Morikawa, A; Suzuki, M | 1 |
| Fukushima, C; Kawano, T; Kohno, S; Kondo, Y; Machida, I; Matsuse, H; Mitsuta, K; Obase, Y; Saeki, S; Shimoda, T; Tomari, S | 1 |
| Basbaum, C; Ishinaga, H; Kishioka, C; Majima, Y; Suzuki, S; Takeuchi, K | 1 |
| Kohno, S; Mizutani, N; Nabe, T; Nakanishi, Y; Takenaka, H | 1 |
| Hagiwara, K; Kanazawa, M; Kikuchi, I; Nagata, M; Saito, K | 1 |
| Furukawa, S; Hasegawa, M; Ichiyama, T; Makata, H; Matsubara, T; Ueno, Y | 1 |
| Hiyama, Y; Ishimura, M; Kataoka, S; Maeda, T; Suda, M | 1 |
| Jin, SM; Kim, SR; Lee, KS; Lee, KY; Lee, YC; Min, KH; Park, HS; Park, SJ | 1 |
| Bai, CH; Kim, YD; Song, SY | 1 |
| Ge, QF; Hu, X; Wei, EQ; Zhang, WP | 1 |
| Fang, SH; Lu, YB; Peng, F; Wei, EQ; Zhang, WP; Zheng, XL | 1 |
| Fang, SH; Li, CT; Lu, YB; Peng, F; Wei, EQ; Yuan, YM; Zhang, LH; Zhang, WP | 1 |
| Haneda, Y; Hasegawa, S; Hashimoto, K; Hirano, R; Ichiyama, T; Ohsaki, A | 1 |
| Arroyo, DS; Iribarren, P; Jesse, AC; Lenz, QF; Marafiga, JR; Masson, CJ; Mello, CF; Poersch, AB; Reschke, CR; Temp, FR | 1 |
| Denton, JS; Figueroa, EE; Kramer, M; Strange, K | 1 |
| Belloni, PA; Bolla, M; Capra, V; Folco, GC; Mezzetti, M; Nicosia, S; Rovati, GE | 1 |
| Abramovitz, M; Austin, CP; Bai, C; Caskey, CT; Chateauneuf, A; Connolly, BM; Coulombe, N; Evans, JF; Figueroa, DJ; Ford-Hutchinson, AW; Greig, GM; Hooks, SB; Hosfield, E; Im, DS; Kargman, S; Liu, Q; Lynch, KR; Metters, KM; O'Neill, GP; Sawyer, N; Stocco, R; Williams, DL; Zeng, Z | 1 |
| Ames, RS; Bergsma, DJ; Buckley, PT; Chambers, J; Dytko, GM; Ellis, C; Elshourbagy, N; Foley, JJ; Halsey, W; Hay, DW; Herrity, NC; Jenkins, O; Muccitelli, RM; Muir, AI; Murdock, PR; Nuthulaganti, P; Sarau, HM; Sathe, G; Schmidt, DB; Wilson, S | 1 |
| Abramovitz, M; Austin, CP; Bellefeuille, JN; Cheng, R; Clements, MK; Coulombe, N; Evans, JF; Figueroa, DJ; George, SR; Heise, CE; Im, DS; Liu, Q; Liu, Y; Lynch, KR; Ma, L; Metters, KM; Nguyen, T; O'Dowd, BF; O'Neill, GP; Sawyer, N; Stocco, R; Williams, DL; Zeng, Z | 1 |
1 review(s) available for ono 1078 and leukotriene d4
| Article | Year |
|---|---|
[Studies on the experimental allergic rhinitis induced by Japanese cedar pollen--role of cysteinyl leukotrienes in nasal allergic symptoms].
Topics: Allergens; Animals; Bronchial Provocation Tests; Chromones; Cryptomeria; Disease Models, Animal; Guinea Pigs; Humans; Inflammation Mediators; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Lipoxygenase Inhibitors; Membrane Proteins; Pollen; Receptors, Leukotriene; Rhinitis, Allergic, Seasonal | 2003 |
2 trial(s) available for ono 1078 and leukotriene d4
| Article | Year |
|---|---|
The single and multiple dose pharmacokinetics of pranlukast in healthy volunteers.
Topics: Adolescent; Adult; Asthma; Chromones; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Leukotriene D4; Middle Aged | 1996 |
Effect of pranlukast, an oral leukotriene receptor antagonist, on leukotriene D4 (LTD4) challenge in normal volunteers.
Topics: Administration, Inhalation; Adult; Airway Resistance; Anti-Asthmatic Agents; Bronchial Provocation Tests; Bronchoconstriction; Chromones; Cross-Over Studies; Double-Blind Method; Histamine; Humans; Leukotriene Antagonists; Leukotriene D4; Male; Time Factors | 1997 |
41 other study(ies) available for ono 1078 and leukotriene d4
| Article | Year |
|---|---|
Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Humans; Leukotriene D4; Macrophages; Mice; Molecular Docking Simulation; Protein Binding; RAW 264.7 Cells; Receptors, G-Protein-Coupled; Receptors, Leukotriene; Structure-Activity Relationship | 2021 |
Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Bronchi; Bronchoconstriction; Capillary Permeability; Chromones; Fatty Acids, Unsaturated; Furans; Guinea Pigs; Hydrazines; Hydroxyurea; Leukotriene D4; Lipoxygenase Inhibitors; Lung; Male; Meclofenamic Acid; Plasma; Prostaglandin Endoperoxides, Synthetic; Pyrilamine; Receptors, Thromboxane; SRS-A; Thromboxane A2; Trachea; Vasoconstrictor Agents | 1995 |
Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats.
Topics: Animals; Chromones; Colon; Disease Models, Animal; Eicosanoids; Female; Inflammatory Bowel Diseases; Leukotriene C4; Leukotriene D4; Methacrylates; Peroxidase; Phenylpropionates; Rats; Rats, Sprague-Dawley; SRS-A; Thromboxane-A Synthase; Trinitrobenzenesulfonic Acid | 1995 |
Inhibitory effect of ONO-1078 on specific binding of peptide leukotrienes to human lung crude membrane.
Topics: Cell Membrane; Chromones; Cysteine; gamma-Glutamyltransferase; Glycine; Humans; Isoxazoles; Leukotriene D4; Lung; Protein Binding; SRS-A | 1994 |
Inhibition by a novel peptide leukotriene receptor antagonist ONO-1078 of airway wall thickening and airway hyperresponsiveness to histamine induced by leukotriene C4 or leukotriene D4 in guinea-pigs.
Topics: Airway Resistance; Animals; Bronchial Hyperreactivity; Chromones; Guinea Pigs; Histamine; Image Processing, Computer-Assisted; Infusions, Intravenous; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Lung; Male; SRS-A | 1994 |
Involvement of endogenous tachykinins in LTD4-induced airway responses.
Topics: Administration, Inhalation; Animals; Bronchi; Bronchoconstriction; Capsaicin; Cell Membrane Permeability; Chromones; Dipeptides; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Guinea Pigs; Indoles; Leukotriene D4; Male; Neurokinin-1 Receptor Antagonists; Respiratory System; Tachykinins | 1996 |
ONO-1078 antagonizes diarrhea-causing changes in ion transport and smooth muscle contraction induced by peptidoleukotrienes in rat and human colon in vitro.
Topics: Adult; Animals; Biological Transport; Chromones; Colon; Diarrhea; Electric Conductivity; Humans; In Vitro Techniques; Intestinal Mucosa; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar | 1996 |
Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Chromones; Cyclooxygenase Inhibitors; Guinea Pigs; Interleukin-5; Leukotriene Antagonists; Leukotriene D4; Meclofenamic Acid; Membrane Proteins; Pulmonary Eosinophilia; Rats; Receptors, Leukotriene | 1996 |
Cysteinyl leukotrienes induce nasal symptoms of allergic rhinitis via a receptor-mediated mechanism in guinea pigs.
Topics: Administration, Oral; Airway Resistance; Animals; Anti-Asthmatic Agents; Binding Sites; Chromones; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; In Vitro Techniques; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Male; Nasal Mucosa; Receptors, Leukotriene; Rhinitis, Allergic, Perennial; Tritium | 1997 |
Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro.
Topics: Adenosine Triphosphate; Animals; Anti-Asthmatic Agents; Binding, Competitive; Chromones; Cysteine; Guinea Pigs; Hypersensitivity; In Vitro Techniques; Indoles; Leukotriene Antagonists; Leukotriene D4; Male; Membrane Proteins; Mucus; Ovalbumin; Passive Cutaneous Anaphylaxis; Phenylcarbamates; Receptors, Leukotriene; Sulfates; Sulfonamides; Sulfur Radioisotopes; Tosyl Compounds; Trachea | 1998 |
The effect of a cysteinyl leukotriene antagonist, ONO-1078 (pranlukast) on agonist- and antigen-induced nasal microvascular leakage in guinea pigs.
Topics: Animals; Anti-Asthmatic Agents; Chromones; Disease Models, Animal; Guinea Pigs; Leukotriene Antagonists; Leukotriene D4; Male; Membrane Proteins; Ovalbumin; Receptors, Leukotriene; Rhinitis, Allergic, Perennial | 1998 |
Effects of LTD4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists.
Topics: Asthma; Carbachol; Cells, Cultured; Chromones; Dicarboxylic Acids; DNA Replication; Epidermal Growth Factor; Extracellular Matrix Proteins; Gene Expression Regulation; Humans; Indoles; Leukotriene Antagonists; Leukotriene D4; Membrane Proteins; Muscle Contraction; Muscle, Smooth, Vascular; Phenylcarbamates; Receptors, Leukotriene; RNA, Messenger; Sulfonamides; Tosyl Compounds; Trachea; Transforming Growth Factor beta | 1998 |
Increased sensitivity to vincristine of MDR cells by the leukotriene D4 receptor antagonist, ONO-1078.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromones; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukotriene Antagonists; Leukotriene D4; Neoplasm Proteins; Tumor Cells, Cultured; Vincristine | 1998 |
Surface-modified antiasthmatic dry powder aerosols inhaled intratracheally reduce the pharmacologically effective dose.
Topics: Administration, Inhalation; Aerosols; Animals; Anti-Asthmatic Agents; Bronchoconstrictor Agents; Chromones; Dose-Response Relationship, Drug; Guinea Pigs; Intubation, Intratracheal; Leukotriene Antagonists; Leukotriene D4; Linear Models; Powders; Reproducibility of Results; Surface Properties | 1998 |
Development of new chromanol antagonists of leukotriene D4.
Topics: Animals; Chromans; Chromones; Guinea Pigs; Humans; Indoles; Leukotriene Antagonists; Leukotriene D4; Phenylcarbamates; Protein Binding; Sulfonamides; Tosyl Compounds | 1998 |
Intratracheal administration of anaphylatoxin C5a potentiates antigen-induced pulmonary reactions through the prolonged production of cysteinyl-leukotrienes.
Topics: Airway Resistance; Animals; Antigens; Bile; Chromones; Complement C5a; Complement C5a, des-Arginine; Cysteine; Diphenhydramine; Histamine H1 Antagonists; Hypersensitivity, Immediate; Inflammation Mediators; Injections, Subcutaneous; Intubation, Intratracheal; Leukotriene Antagonists; Leukotriene D4; Leukotriene E4; Leukotrienes; Lung; Male; Membrane Proteins; Ovalbumin; Rats; Rats, Inbred BN; Receptors, Leukotriene; Zymosan | 2000 |
Pranlukast protects leukotriene C4- and D4-induced epithelial cell impairment of the nasal mucosa in vitro.
Topics: Adult; Cells, Cultured; Chromones; Cilia; Humans; Kinetics; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Male; Nasal Mucosa; Time Factors | 2000 |
Leukotriene D(4)-induced Rho-mediated actin reorganization in human bronchial smooth muscle cells.
Topics: Actins; ADP Ribose Transferases; Botulinum Toxins; Bronchi; Chromones; Fluorescein-5-isothiocyanate; Fluorescent Dyes; GTP-Binding Proteins; Humans; Leukotriene Antagonists; Leukotriene D4; Membrane Proteins; Muscle, Smooth; Pertussis Toxin; Phosphorylation; Protein-Tyrosine Kinases; Receptors, Leukotriene; rho GTP-Binding Proteins; Signal Transduction; Tyrosine; Virulence Factors, Bordetella; Xanthenes | 2001 |
Effects of pranlukast on chemical mediators in induced sputum on provocation tests in atopic and aspirin-intolerant asthmatic patients.
Topics: Adult; Anti-Asthmatic Agents; Aspirin; Asthma; Blood Proteins; Bronchial Provocation Tests; Chromones; Drug Hypersensitivity; Eosinophil Granule Proteins; Eosinophils; Female; Forced Expiratory Volume; Humans; Leukocyte Count; Leukotriene D4; Leukotriene E4; Male; Middle Aged; Ribonucleases; Thromboxane B2 | 2002 |
Experimental otitis media with effusion induced by leukotriene D4.
Topics: Animals; Chromones; Cytokines; Humans; Leukotriene Antagonists; Leukotriene D4; Male; Models, Animal; Otitis Media with Effusion; Rats; Rats, Wistar; Severity of Illness Index | 2002 |
Pharmacological differences among CysLT(1) receptor antagonists with respect to LTC(4) and LTD(4) in human lung parenchyma.
Topics: Acetates; Anti-Asthmatic Agents; Binding, Competitive; Chromones; Cyclopropanes; Humans; Kinetics; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Membrane Proteins; Quinolines; Receptors, Leukotriene; Sulfides | 2002 |
Pranlukast inhibits NF-kappa B activation in human monocytes/macrophages and T cells.
Topics: Chromones; Cytokines; Dimethyl Sulfoxide; Humans; Interleukin-6; Jurkat Cells; Leukocytes, Mononuclear; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Lipopolysaccharides; NF-kappa B; Propionates; Quinolines; Statistics, Nonparametric; U937 Cells | 2003 |
Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078).
Topics: Cell Degranulation; Chromones; Eosinophils; Humans; Immunity, Cellular; Leukotriene Antagonists; Leukotriene D4; Macrophage-1 Antigen; Membrane Proteins; Phorbol Esters; Platelet Activating Factor; Receptors, Leukotriene; Superoxides | 2003 |
Cysteinyl leukotrienes induce nuclear factor kappa b activation and RANTES production in a murine model of asthma.
Topics: Animals; Antigens, Dermatophagoides; Asthma; Bronchial Hyperreactivity; Bronchitis; Chemokine CCL5; Chromones; Cysteine; Cytokines; Female; Inflammation Mediators; Leukotriene Antagonists; Leukotriene D4; Leukotrienes; Lung; Mice; Mice, Inbred BALB C; Monocytes; NF-kappa B; Transcription Factor RelA | 2003 |
Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells.
Topics: Cell Line, Tumor; Chromones; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Leukotriene Antagonists; Leukotriene D4; Lipopolysaccharides; Membrane Proteins; Mucin 5AC; Mucin-2; Mucins; NF-kappa B; Receptors, Leukotriene; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transfection | 2005 |
Synergism between cysteinyl leukotrienes and thromboxane A2 to induce allergic late phase nasal blockage in guinea pigs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzoquinones; Chromones; Guinea Pigs; Heptanoic Acids; Hypersensitivity; Leukotriene D4; Leukotrienes; Male; Nasal Cavity; Thromboxane A2 | 2004 |
Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils.
Topics: Adult; Cell Movement; Chemokine CCL11; Chemokine CCL5; Chemokines, CC; Chromones; Drug Interactions; Endothelial Cells; Eosinophils; Female; Humans; Leukotriene Antagonists; Leukotriene D4; Male; Membrane Proteins; Platelet Activating Factor; Receptors, Leukotriene | 2005 |
Cysteinyl leukotrienes induce monocyte chemoattractant protein 1 in human monocytes/macrophages.
Topics: Blotting, Western; Cell Line, Tumor; Chemokine CCL11; Chemokine CCL2; Chemokines, CC; Chromones; Cytokines; Humans; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Lipopolysaccharide Receptors; Macrophage Colony-Stimulating Factor; Macrophages; Monocytes; Receptors, CCR2; Receptors, Chemokine; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Statistics, Nonparametric; Tumor Necrosis Factor-alpha | 2005 |
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuterol; Animals; Atropine; Benzoquinones; Carbachol; Chromones; Cyclopropanes; Dinoprost; Drug Evaluation, Preclinical; Guinea Pigs; Heptanoic Acids; Histamine; In Vitro Techniques; Indoles; Indomethacin; Ketanserin; Ketotifen; Leukotriene Antagonists; Leukotriene D4; Male; Muscle Contraction; Muscle, Smooth; Phenylcarbamates; Powders; Procaterol; Prostaglandin Antagonists; Prostaglandin D2; Quinolines; Receptors, Thromboxane A2, Prostaglandin H2; Serotonin; Substance P; Sulfides; Sulfonamides; Tosyl Compounds; Trachea; Tryptophan | 2006 |
Cysteinyl leukotriene upregulates IL-11 expression in allergic airway disease of mice.
Topics: Acetates; Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chromones; Collagen; Cyclopropanes; Epithelial Cells; Female; Interleukin-11; Interleukin-13; Interleukin-4; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Lung; Mice; Mice, Inbred C57BL; Nitriles; Ovalbumin; Quinolines; Respiratory Hypersensitivity; RNA, Messenger; Sulfides; Sulfones; Transcription Factor RelA | 2007 |
The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells.
Topics: Carcinoma, Mucoepidermoid; Cell Line, Tumor; Chromones; Down-Regulation; Gene Expression; Humans; Leukotriene Antagonists; Leukotriene D4; Lung Neoplasms; Mucin 5AC; Mucin-2; Mucins; Receptors, Leukotriene; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation | 2007 |
[Effects of cysteinyl receptor agonist and antagonists on rat primary cortical neurons].
Topics: Acetates; Animals; Animals, Newborn; Calcium; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Chromones; Cyclopropanes; Glucose; Leukotriene Antagonists; Leukotriene D4; Neurons; Quinolines; Rats; Receptors, Leukotriene; Sulfides | 2007 |
[Cysteinyl leukotriene receptor 1 antagonist pranlukast modulates differentiation of SK-N-SH cells].
Topics: Cell Differentiation; Cell Line, Tumor; Chromones; Humans; Immunoblotting; Immunohistochemistry; Leukotriene Antagonists; Leukotriene D4; Membrane Proteins; Microtubule-Associated Proteins; Neuroblastoma; Receptors, Leukotriene | 2007 |
Pranlukast attenuates ischemia-like injury in endothelial cells via inhibiting reactive oxygen species production and nuclear factor-kappaB activation.
Topics: Arachidonate 5-Lipoxygenase; Cell Line; Cell Nucleus; Cell Survival; Chromones; Endothelial Cells; Glucose; Humans; Ischemia; Leukotriene Antagonists; Leukotriene D4; Leukotrienes; Necrosis; NF-kappa B; Oxygen; Reactive Oxygen Species | 2009 |
Leukotriene D4 enhances tumor necrosis factor-α-induced vascular endothelial growth factor production in human monocytes/macrophages.
Topics: Cell Line; Chromones; Gene Expression Regulation; Humans; Leukotriene D4; Lipopolysaccharide Receptors; Macrophages; Monocytes; RNA, Messenger; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2011 |
Cysteinyl leukotriene receptor (CysLT) antagonists decrease pentylenetetrazol-induced seizures and blood-brain barrier dysfunction.
Topics: Acetates; Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Capillary Permeability; Chromones; Cyclopropanes; Dose-Response Relationship, Drug; Immunoglobulin G; Leukocyte Common Antigens; Leukocytes; Leukotriene Antagonists; Leukotriene D4; Male; Mice; Neuroprotective Agents; Pentylenetetrazole; Quinolines; Receptors, Leukotriene; Seizures; SRS-A; Sulfides | 2014 |
CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor.
Topics: Anions; Cell Size; Chromones; Epithelial Cells; HEK293 Cells; Humans; Indoles; Leukotriene Antagonists; Leukotriene D4; Membrane Proteins; Phenylcarbamates; Receptors, Leukotriene; Signal Transduction; Sulfonamides; Tosyl Compounds | 2019 |
Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro.
Topics: Antigens; Benzopyrans; Binding, Competitive; Bronchi; Humans; In Vitro Techniques; Leukotriene D4; Lung; Muscle Contraction | 1998 |
Characterization of the human cysteinyl leukotriene CysLT1 receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Chromosome Mapping; Cloning, Molecular; COS Cells; Humans; Leukotriene Antagonists; Leukotriene D4; Lung; Macrophages, Alveolar; Membrane Proteins; Molecular Sequence Data; Muscle, Smooth; Receptors, Leukotriene; Tissue Distribution; Transfection; X Chromosome; Xenopus laevis | 1999 |
Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Biological Transport; Calcium; Cells, Cultured; Cloning, Molecular; Humans; Leukotriene D4; Membrane Proteins; Molecular Sequence Data; Pertussis Toxin; Receptors, Leukotriene; Signal Transduction; Virulence Factors, Bordetella | 1999 |
Characterization of the human cysteinyl leukotriene 2 receptor.
Topics: Adrenal Medulla; Cloning, Molecular; Cysteine; Humans; Leukotriene Antagonists; Leukotriene C4; Leukotriene D4; Leukotriene E4; Leukotrienes; Lung; Membrane Proteins; Models, Molecular; Myocardium; Receptors, Leukotriene; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; SRS-A; Tissue Distribution | 2000 |