Page last updated: 2024-09-04

omeprazole sulfone and omeprazole

omeprazole sulfone has been researched along with omeprazole in 46 studies

Compound Research Comparison

Studies
(omeprazole sulfone)
Trials
(omeprazole sulfone)
Recent Studies (post-2010)
(omeprazole sulfone)
Studies
(omeprazole)
Trials
(omeprazole)
Recent Studies (post-2010) (omeprazole)
5012179,0852,7371,487

Protein Interaction Comparison

ProteinTaxonomyomeprazole sulfone (IC50)omeprazole (IC50)
Mcl-1Homo sapiens (human)3.1448
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.28
Potassium-transporting ATPase alpha chain 1Homo sapiens (human)1.45
Cytochrome P450 2C19Homo sapiens (human)2.315
Potassium-transporting ATPase subunit betaHomo sapiens (human)1.45
WD repeat-containing protein 5Homo sapiens (human)1.7
Glutathione S-transferase omega-1Homo sapiens (human)4.6
Histone-lysine N-methyltransferase 2AHomo sapiens (human)1.7
Muscarinic acetylcholine receptorCavia porcellus (domestic guinea pig)3.8

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-19903 (6.52)18.7374
1990's9 (19.57)18.2507
2000's21 (45.65)29.6817
2010's12 (26.09)24.3611
2020's1 (2.17)2.80

Authors

AuthorsStudies
Afzelius, L; Andersson, TB; Baroni, M; Cruciani, G; Karlén, A; Masimirembwa, CM; Mecucci, S; Zamora, I1
Isoherranen, N; Lutz, JD1
Chiba, K; Ishizaki, T; Kobayashi, K; Lee, KH; Shin, SG; Sohn, DR1
Andersson, T; Lagerström, PO; Lundborg, P; Regårdh, CG; Skånberg, I1
Andersson, T; Bodemar, G; Larsson, R; Naesdal, J; Regårdh, CG; Skånberg, I; Walan, A1
Jones, DB; Mihaly, GW; Morgan, DJ; Smallwood, RA; Webster, LK1
Louis, WJ; Mihaly, GW; Prichard, PJ; Smallwood, RA; Yeomans, ND1
Chiba, K; Ishizaki, T; Kobayashi, K; Kuroiwa, Y; Tani, M1
Chiba, K; Ishizaki, T; Kamataki, T; Kobayashi, K; Manabe, K; Tani, M1
Brockmöller, J; Esdorn, F; Roots, I; Rost, KL1
Roots, I; Rost, KL1
Houston, JB; Zomorodi, K1
Ashton, M; Bertilsson, L; Dinh, XH; Le, DC; Lykkesfeldt, J; Nguyen, DS; Nguyen, TN; Nguyen, VH; Svensson, US; Trinh, NH1
Tassaneeyakul, W; Vannaprasaht, S; Yamazoe, Y1
Farrán, R; García-Encina, G; Martínez, L; Puig, S1
Abelö, A; Andersson, TB; Antonsson, M; Naudot, AK; Skånberg, I; Weidolf, L1
He, N; Huang, SL; Shu, Y; Wang, LS; Wang, W; Xiao, WM; Xu, ZH; Zhou, HH1
Jeong, JE; Park, JY; Yim, DS1
Huang, SL; Shu, Y; Wang, LS; Wang, W; Xiao, WM; Zhou, HH1
Chow, AH; Chow, MS; Tomlinson, B; Waye, MM; Yin, OQ2
Bertilsson, L; Kim, PS; Lee, DH; Park, CS; Roh, HK; Sagar, M; Seensalu, R; Tybring, G1
Ishizawa, Y; Sasaki, M; Takahata, T; Tateishi, T; Yasui-Furukori, N1
Bravo, E; Galera, R; Martínez-Lozano, C; Pérez-Ruiz, T; Sanz, A1
Hofmann, U; Klotz, U; Leodolter, A; Malfertheiner, P; Schaeffeler, E; Schwab, M; Treiber, G1
Cervantes, R; González, H; Hoyo-Vadillo, C; Mata, N; Ortiz, AC; Ramírez-Mayans, J; Rincón, V; Romero, E; Sosa, C; Venturelli, CR; Zarate, F1
Bertino, JS; Kim, MJ; Nafziger, AN; Sellers, EM; Zhang, Y1
Böttiger, Y1
Brown, KC; Kashuba, AD; Rezk, NL1
Hultman, Ia; Liljeblad, M; Stenhoff, H1
Bottoli, CB; Collins, CH; Ribani, M1
Chen, Y; Fan, L; Hu, DL; Huang, RX; Huang, YF; Wang, D; Wang, G; Wang, LS; Zhang, W; Zhou, HH1
Sugimoto, K; Tateishi, T; Uno, T1
Eom, SO; Jin, SK; Kang, TS; Kim, JI; Lee, HJ; Roh, J1
Aklillu, E; Aminy, A; Bijnsdorp, A; Diczfalusy, U; Engidawork, E; Gebeyehu, E1
Baldwin, RM; Capparelli, EV; Ingelman-Sundberg, M; Lawson, EB; Ma, JD; Rosenborg, S; Wu, JC; Yim, DS; Yin, OQ1
Aregbe, AO; Desta, Z; Flockhart, DA; Michaud, V; Ogburn, E; Quigg, TC; Thong, N1
Akamine, Y; Shiohira, H; Tateishi, T; Uno, T; Yamada, S; Yasui-Furukori, N1
Davis, C; Isoherranen, N; Lutz, JD; Sager, JE; Shirasaka, Y1
Ahmad, L; Iqbal, Z; Nasir, F; Nazir, S; Shah, Y1
Dorado, RM; Nevado, JJ; Peñalvo, GC; Robledo, VR1
Barocelli, E; Bettini, R; Castrati, L; Colombo, P; Elviri, L; Flammini, L; Rossi, A1
Ahmad, L; Ahmad, S; Iqbal, Z; Nazir, S1
Ahmad, L; Iqbal, Z; Khan, A; Khan, I; Khan, MI; Khuda, F; Nazir, S; Shah, Y1
Aboagye, EO; Clarke, S; Edwards, RJ; Lee, P; Liddle, C; Lozan-Kuehne, JP; Maslen, L; Ramaswami, R; Sharma, R; Trousil, S1
Ferlini Agne, G; Franklin, S; Knych, H; Somogyi, AA; Sykes, B1

Reviews

1 review(s) available for omeprazole sulfone and omeprazole

ArticleYear
Comparative pharmacokinetics of Omeprazole and its metabolites in poor and extensive metabolizer Pakistani healthy volunteers and a review of different studies.
    Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Area Under Curve; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Genotype; Healthy Volunteers; Humans; Omeprazole

2018

Trials

12 trial(s) available for omeprazole sulfone and omeprazole

ArticleYear
Formation of omeprazole sulphone but not 5-hydroxyomeprazole is inhibited by grapefruit juice.
    British journal of clinical pharmacology, 2000, Volume: 49, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Citrus; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Male; Mixed Function Oxygenases; Omeprazole; Time Factors

2000
Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability.
    Journal of clinical pharmacology, 2004, Volume: 44, Issue:6

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Cross-Over Studies; Cytochrome P-450 CYP2C19; Enzyme Inhibitors; Gene Dosage; Humans; Hydroxylation; Male; Mephenytoin; Mixed Function Oxygenases; Omeprazole; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Reference Values

2004
Omeprazole treatment of Korean patients: effects on gastric pH and gastrin release in relation to CYP2C19 geno- and phenotypes.
    Basic & clinical pharmacology & toxicology, 2004, Volume: 95, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Ulcer Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Female; Gastric Acidity Determination; Gastrins; Genotype; Humans; Hydrogen-Ion Concentration; Korea; Male; Middle Aged; Mixed Function Oxygenases; Omeprazole; Phenotype; Stomach Diseases

2004
Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data.
    Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:6

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Aged; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Case-Control Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Esomeprazole; Female; Gastroesophageal Reflux; Genotype; H(+)-K(+)-Exchanging ATPase; Half-Life; Humans; Male; Middle Aged; Mixed Function Oxygenases; Omeprazole; Prospective Studies; Proton Pump Inhibitors; Time Factors

2005
Use of omeprazole sulfone in a single plasma sample as a probe for CYP3A4.
    European journal of clinical pharmacology, 2006, Volume: 62, Issue:8

    Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Carbamazepine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Ketoconazole; Male; Middle Aged; Mixed Function Oxygenases; Omeprazole; Pharmacogenetics

2006
Herbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole.
    Acta pharmacologica Sinica, 2007, Volume: 28, Issue:10

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Area Under Curve; Artemisia; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Combinations; Drugs, Chinese Herbal; Genotype; Herb-Drug Interactions; Humans; Hydroxylation; Male; Omeprazole; Plants, Medicinal; Safrole

2007
CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole.
    Journal of clinical pharmacy and therapeutics, 2009, Volume: 34, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Alleles; Anti-Ulcer Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Female; Half-Life; Haplotypes; Humans; Korea; Male; Omeprazole; Polymorphism, Single Nucleotide; Young Adult

2009
Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping.
    European journal of clinical pharmacology, 2012, Volume: 68, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Anti-Ulcer Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Female; Genotype; Humans; Male; Models, Biological; Omeprazole; Phenotype; White People; Young Adult

2012
Induction of CYP2C19 and CYP3A activity following repeated administration of efavirenz in healthy volunteers.
    Clinical pharmacology and therapeutics, 2012, Volume: 91, Issue:3

    Topics: Adult; Alkynes; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Cyclopropanes; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Hydroxylation; Male; Omeprazole; Reverse Transcriptase Inhibitors

2012
Pharmacokinetics of omeprazole and its metabolites in three phases of menstrual cycle.
    European journal of drug metabolism and pharmacokinetics, 2015, Volume: 40, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Female; Follicular Phase; Healthy Volunteers; Humans; Luteal Phase; Menstrual Cycle; Menstruation; Metabolic Clearance Rate; Omeprazole; Proton Pump Inhibitors; Spectrophotometry, Ultraviolet

2015
Variation in pharmacokinetics of omeprazole and its metabolites by gender and CYP2C19 genotype in Pakistani male and female subjects.
    Pakistan journal of pharmaceutical sciences, 2016, Volume: 29, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Area Under Curve; Biotransformation; Cytochrome P-450 CYP2C19; Female; Heterozygote; Homozygote; Humans; Hydroxylation; Linear Models; Male; Metabolic Clearance Rate; Models, Biological; Omeprazole; Pakistan; Pharmacogenetics; Phenotype; Proton Pump Inhibitors; Sex Factors; Young Adult

2016
Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation.
    British journal of pharmacology, 2019, Volume: 176, Issue:18

    Topics: Adult; Aged; Aged, 80 and over; C-Reactive Protein; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Cytokines; Dextromethorphan; Female; Humans; Inflammation; Middle Aged; Omeprazole; Ovarian Neoplasms

2019

Other Studies

33 other study(ies) available for omeprazole sulfone and omeprazole

ArticleYear
Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors.
    Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4

    Topics: Amino Acids; Aryl Hydrocarbon Hydroxylases; Binding Sites; Cytochrome P-450 CYP2C9; Enzyme Inhibitors; Models, Molecular; Molecular Conformation; Molecular Structure; Quantitative Structure-Activity Relationship

2004
Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1

    Topics: Dextromethorphan; Humans; Microsomes, Liver; Omeprazole; Predictive Value of Tests

2012
Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Humans; Hydroxylation; Korea; Male; Mephenytoin; Omeprazole

1992
The pharmacokinetics of omeprazole in humans--a study of single intravenous and oral doses.
    Therapeutic drug monitoring, 1990, Volume: 12, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Biological Availability; Biotransformation; Feces; Half-Life; Humans; Injections, Intravenous; Male; Omeprazole

1990
Pharmacokinetics of [14C]omeprazole in patients with impaired renal function.
    Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:3

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Benzimidazoles; Blood Proteins; Female; Humans; Kidney Failure, Chronic; Kinetics; Male; Mathematics; Middle Aged; Omeprazole

1986
Effect of hypoxia on oxidative and reductive pathways of omeprazole metabolism by the isolated perfused rat liver.
    Biochemical pharmacology, 1985, Apr-15, Volume: 34, Issue:8

    Topics: Animals; Benzimidazoles; Hypoxia; Lactates; Lactic Acid; Liver; Male; Omeprazole; Oxidation-Reduction; Oxygen; Perfusion; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains

1985
Simultaneous high-performance liquid chromatographic analysis of omeprazole and its sulphone and sulphide metabolites in human plasma and urine.
    Journal of chromatography, 1983, Dec-09, Volume: 278, Issue:2

    Topics: Adult; Benzimidazoles; Chromatography, High Pressure Liquid; Humans; Kinetics; Male; Omeprazole; Tablets, Enteric-Coated

1983
Development and preliminary application of a high-performance liquid chromatographic assay for omeprazole metabolism in human liver microsomes.
    Journal of pharmaceutical and biomedical analysis, 1994, Volume: 12, Issue:6

    Topics: Chromatography, High Pressure Liquid; Humans; Microsomes, Liver; Omeprazole; Proton Pumps; Reproducibility of Results

1994
Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Oxidation-Reduction; Sulfur

1993
Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment.
    Journal of hepatology, 1995, Volume: 23, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Ulcer Agents; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Liver Diseases; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Omeprazole; Peptic Ulcer; Phenotype; Polymorphism, Genetic

1995
Nonlinear kinetics after high-dose omeprazole caused by saturation of genetically variable CYP2C19.
    Hepatology (Baltimore, Md.), 1996, Volume: 23, Issue:6

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Genetic Variation; Humans; Male; Middle Aged; Mixed Function Oxygenases; Omeprazole; Phenotype; Proton Pump Inhibitors

1996
Selectivity of omeprazole inhibition towards rat liver cytochromes P450.
    Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:1

    Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diazepam; Ethylmorphine-N-Demethylase; Ketoconazole; Male; Microsomes, Liver; Omeprazole; Rats; Rats, Sprague-Dawley; Substrate Specificity

1997
Artemisinin induces omeprazole metabolism in human beings.
    Clinical pharmacology and therapeutics, 1998, Volume: 64, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Antimalarials; Area Under Curve; Artemisinins; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Male; Middle Aged; Mixed Function Oxygenases; Omeprazole; Reference Values; Sesquiterpenes; Time Factors

1998
Validation of an automated liquid chromatographic method for omeprazole in human plasma using on-line solid-phase extraction.
    Journal of pharmaceutical and biomedical analysis, 1999, Volume: 21, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Automation; Chromatography, High Pressure Liquid; Drug Stability; Flow Injection Analysis; Humans; Omeprazole; Quality Control; Reproducibility of Results

1999
Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:8

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Stereoisomerism

2000
5-hydroxylation of omeprazole by human liver microsomal fractions from Chinese populations related to CYP2C19 gene dose and individual ethnicity.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2

    Topics: Adult; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethnicity; Gene Dosage; Genotype; Humans; Hydroxylation; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Substrate Specificity; Troleandomycin

2000
Assay of omeprazole and omeprazole sulfone by semi-microcolumn liquid chromatography with mixed-function precolumn.
    Journal of chromatography. B, Biomedical sciences and applications, 2001, Apr-25, Volume: 754, Issue:2

    Topics: Anti-Ulcer Agents; Calibration; Chromatography, Liquid; Humans; Omeprazole; Quality Control; Reproducibility of Results

2001
Probing CYP2C19 and CYP3A4 activities in Chinese liver microsomes by quantification of 5-hydroxyomeprazole and omeprazole sulphone.
    Acta pharmacologica Sinica, 2000, Volume: 21, Issue:8

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole

2000
Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole.
    Pharmacogenetics, 2004, Volume: 14, Issue:12

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2C19; Enzyme Inhibitors; Ginkgo biloba; Herb-Drug Interactions; Humans; Male; Mixed Function Oxygenases; Omeprazole; Pharmacogenetics; Plant Extracts; Time Factors

2004
The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics.
    Clinical pharmacokinetics, 2005, Volume: 44, Issue:11

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Aging; Alleles; Analysis of Variance; Anti-Ulcer Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Genotype; Heterozygote; Homozygote; Humans; Linear Models; Mixed Function Oxygenases; Mutation; Omeprazole

2005
Determination of omeprazole, hydroxyomeprazole and omeprazole sulfone using automated solid phase extraction and micellar electrokinetic capillary chromatography.
    Journal of pharmaceutical and biomedical analysis, 2006, Sep-11, Volume: 42, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Electrophoresis, Capillary; Micelles; Omeprazole; Pharmaceutical Preparations

2006
Metabolism of omeprazole after two oral doses in children 1 to 9 months old.
    Proceedings of the Western Pharmacology Society, 2005, Volume: 48

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Gene Frequency; Humans; Infant; Infant, Newborn; Male; Mexico; Mixed Function Oxygenases; Omeprazole; Phenotype

2005
Use of omeprazole as a CYP3A probe drug: effect of sex and menstrual cycle phase on CYP3A activity in healthy Caucasian adults.
    Journal of clinical pharmacology, 2006, Volume: 46, Issue:3

    Topics: Adult; Biomarkers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Humans; Male; Menstrual Cycle; Middle Aged; Omeprazole; Progesterone; Sex Factors; White People

2006
A simple and sensitive bioanalytical assay for simultaneous determination of omeprazole and its three major metabolites in human blood plasma using RP-HPLC after a simple liquid-liquid extraction procedure.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Dec-05, Volume: 844, Issue:2

    Topics: Chromatography, High Pressure Liquid; Drug Stability; Humans; Molecular Structure; Omeprazole; Reproducibility of Results

2006
Determination of esomeprazole and its two main metabolites in human, rat and dog plasma by liquid chromatography with tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Apr-01, Volume: 848, Issue:2

    Topics: Animals; Calibration; Chromatography, Liquid; Dogs; Esomeprazole; Humans; Molecular Structure; Omeprazole; Rats; Reproducibility of Results; Tandem Mass Spectrometry

2007
Validation of chromatographic methods: evaluation of detection and quantification limits in the determination of impurities in omeprazole.
    Journal of chromatography. A, 2007, Jul-13, Volume: 1156, Issue:1-2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chromatography, High Pressure Liquid; Drug Contamination; Omeprazole; Uncertainty

2007
Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19 PMs.
    European journal of clinical pharmacology, 2008, Volume: 64, Issue:6

    Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Female; Genotype; Humans; Male; Omeprazole

2008
Sex and CYP3A5 genotype influence total CYP3A activity: high CYP3A activity and a unique distribution of CYP3A5 variant alleles in Ethiopians.
    The pharmacogenomics journal, 2011, Volume: 11, Issue:2

    Topics: Adult; Alleles; Black People; Cholesterol; Cytochrome P-450 CYP3A; Ethiopia; Female; Genetic Variation; Genotype; Humans; Hydroxycholesterols; Male; Omeprazole; Sex Factors; Young Adult

2011
The (R)-omeprazole hydroxylation index reflects CYP2C19 activity in healthy Japanese volunteers.
    European journal of clinical pharmacology, 2013, Volume: 69, Issue:7

    Topics: Alleles; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Drug Monitoring; Exons; Genetic Association Studies; Humans; Hydroxylation; Japan; Metabolic Detoxication, Phase I; Omeprazole; Pilot Projects; Polymorphism, Genetic; Proton Pump Inhibitors; Stereoisomerism

2013
Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:7

    Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Humans; Omeprazole

2013
Simultaneous determination of omeprazole and their main metabolites in human urine samples by capillary electrophoresis using electrospray ionization-mass spectrometry detection.
    Journal of pharmaceutical and biomedical analysis, 2014, Volume: 92

    Topics: Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Humans; Omeprazole; Spectrometry, Mass, Electrospray Ionization

2014
Development and validation of a DESI-HRMS/MS method for the fast profiling of esomeprazole and its metabolites in rat plasma: a pharmacokinetic study.
    Drug testing and analysis, 2016, Volume: 8, Issue:2

    Topics: Animals; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Esomeprazole; Limit of Detection; Liquid-Liquid Extraction; Male; Omeprazole; Proton Pump Inhibitors; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2016
Identification and kinetics of microsomal and recombinant equine liver cytochrome P450 enzymes responsible for in vitro metabolism of omeprazole.
    Biochemical pharmacology, 2023, Volume: 214

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Horses; Humans; Kinetics; Liver; Microsomes, Liver; Omeprazole; Sulfones

2023