Page last updated: 2024-09-04

omeprazole sulfone and mephenytoin

omeprazole sulfone has been researched along with mephenytoin in 4 studies

Compound Research Comparison

Studies (omeprazole sulfone)	Trials (omeprazole sulfone)	Recent Studies (post-2010) (omeprazole sulfone)	Studies (mephenytoin)	Trials (mephenytoin)	Recent Studies (post-2010) (mephenytoin)
50	12	17	580	35	32

Protein Interaction Comparison

Protein	Taxonomy	omeprazole sulfone (IC50)	mephenytoin (IC50)
Cytochrome P450 2C19	Homo sapiens (human)		1.185

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (50.00)	18.2507
2000's	2 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chiba, K; Ishizaki, T; Kobayashi, K; Lee, KH; Shin, SG; Sohn, DR	1
Brockmöller, J; Esdorn, F; Roots, I; Rost, KL	1
He, N; Huang, SL; Shu, Y; Wang, LS; Wang, W; Xiao, WM; Xu, ZH; Zhou, HH	1
Chow, AH; Chow, MS; Tomlinson, B; Waye, MM; Yin, OQ	1

Trials

1 trial(s) available for omeprazole sulfone and mephenytoin

Article	Year
Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability. Journal of clinical pharmacology, 2004, Volume: 44, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Cross-Over Studies; Cytochrome P-450 CYP2C19; Enzyme Inhibitors; Gene Dosage; Humans; Hydroxylation; Male; Mephenytoin; Mixed Function Oxygenases; Omeprazole; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Reference Values	2004

Article

Year

Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability.

Journal of clinical pharmacology, 2004, Volume: 44, Issue:6

Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Asian People; Cross-Over Studies; Cytochrome P-450 CYP2C19; Enzyme Inhibitors; Gene Dosage; Humans; Hydroxylation; Male; Mephenytoin; Mixed Function Oxygenases; Omeprazole; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Reference Values

2004

Other Studies

3 other study(ies) available for omeprazole sulfone and mephenytoin

Article	Year
Disposition kinetics and metabolism of omeprazole in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation recruited from an Oriental population. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Humans; Hydroxylation; Korea; Male; Mephenytoin; Omeprazole	1992
Phenocopies of poor metabolizers of omeprazole caused by liver disease and drug treatment. Journal of hepatology, 1995, Volume: 23, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Ulcer Agents; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Female; Genotype; Humans; Liver Diseases; Male; Mephenytoin; Middle Aged; Mixed Function Oxygenases; Omeprazole; Peptic Ulcer; Phenotype; Polymorphism, Genetic	1995
5-hydroxylation of omeprazole by human liver microsomal fractions from Chinese populations related to CYP2C19 gene dose and individual ethnicity. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:2 Topics: Adult; Antibodies, Monoclonal; Aryl Hydrocarbon Hydroxylases; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Ethnicity; Gene Dosage; Genotype; Humans; Hydroxylation; Mephenytoin; Microsomes, Liver; Mixed Function Oxygenases; Omeprazole; Substrate Specificity; Troleandomycin	2000