omeprazole and rifampin

omeprazole has been researched along with rifampin in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (7.02)	18.2507
2000's	18 (31.58)	29.6817
2010's	26 (45.61)	24.3611
2020's	9 (15.79)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Amore, BM; Banfield, C; Boudreaux, MD; Davis, JA; Emery, MG; Foti, RS; Pearson, JT; Prokop, SP; Rock, DA; Wahlstrom, JL; Wienkers, LC; Wong, SL; Zalikowski, JA	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bharate, SS; Vishwakarma, RA	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Baell, JB; Board, PG; Casarotto, MG; Dahlin, JL; Oakley, AJ; Xie, Y	1
Chen, J; Ding, C; Doyle, T; Duncan, L; Ebright, RH; He, S; Lin, W; Liu, Y; Lynch, AS; Ma, Z; Molodtsov, V; Nguyen, P; Pulse, M; Robertson, GT; Wang, H; Weiss, WJ; Xu, X; Yuan, Y; Zhuang, Z	1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF	1
Bories, P; Daujat, M; Diaz, D; Fabre, I; Maurel, P; Michel, H; Saint Aubert, B	1
Hirata, M; Nishibe, Y	2
Li, AP; Masubuchi, N; Okazaki, O	1
Li, AP; Lu, C	1
Hiraoka, I; Naito, S; Nishimura, M; Yoshitsugu, H	1
Allen, SW; Raucy, J; Warfe, L; Yueh, MF	1
Booker, BM; Brazeau, D; Cloen, D; Frerichs, V; Frye, RF; Haas, CE; Kufel, T; Zaranek, C	1
Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T	1
Kawano, Y; Koeda, A; Naito, S; Nakayama, M; Narimatsu, S; Nishimura, M; Satoh, T; Shimizu, T; Suzuki, E	1
Kawano, Y; Koeda, A; Naito, S; Nakayama, M; Narimatsu, S; Nishimura, M; Satoh, T; Suzuki, E	1
Bumb, RA; Kochar, DK; Kochar, SK; Mehta, RD; Purohit, SK; Saini, G; Sirohi, P	1
Koeda, A; Naito, S; Nakayama, M; Narimatsu, S; Nishimura, M; Satoh, T; Shimizu, T; Suganuma, Y; Suzuki, E	1
Dial, S; Guo, L; Ning, B; Sun, Y; Wang, J; Yang, J	1
Andersson, TB; Bäckström, T; Bertilsson, L; Böttiger, Y; Bredberg, E; Diczfalusy, U; Kanebratt, KP; Sparve, E	1
de Barros e Silva, MJ; de Paiva, TF; Fanelli, MF; Gimenes, DL; Rinck, JA	1
Koeda, A; Morikawa, H; Naito, S; Narimatsu, S; Nishimura, M; Satoh, T	1
Abadie-Viollon, C; Alexandre, E; Bachellier, P; Blanchard, N; Coassolo, P; Heyd, B; Mantion, G; Martin, H; Pekthong, D; Richert, L; Schuler, F	1
Burger, DM	1
Anthérieu, S; Camus, S; Chesné, C; Guguen-Guillouzo, C; Guillouzo, A; Lahoz, A; Li, R; Picazo, L; Tolonen, A; Turpeinen, M; Uusitalo, J	1
Akiyama, H; Ise, R; Iwasaki, K; Kondo, S; Nagata, R; Nobumasa, H; Uehara, S; Uno, Y; Yamazaki, H	1
Jiang, K; Li, F; Li, K; Lu, X; Qin, F	1
Aizawa, K; Kato, N; Mizutani, R; Nakamura, K; Tanoue, A; Yamauchi, J	1
Akamatsu, T; Chida, K; Inui, N; Karayama, M; Namiki, N; Tanaka, S; Uchida, S; Watanabe, H	1
Buchbjerg, JK; Chen, G; Højer, AM; Lee, R; Serenko, M; Zhao, Z	1
Bradfield, CA; Johnson, BP; Sengupta, S; Stewart, R; Swanson, SA; Thomson, JA	1
Hori, Y; Ohara, Y; Takahashi, Y; Tanaka, H; Urashima, T; Yamamoto, T	1
Inoue, T; Sasaki, E; Suzuki, T; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H	1
Damanhuri, NS; Kumolosasi, E; Omar, MS	1
Bae, SH; Han, S; Park, GJ; Park, MH; Park, WS; Shin, SH; Shin, YG; Yim, DS	1
Inoue, T; Kusama, T; Mogi, M; Sasaki, E; Shimizu, M; Toda, A; Uehara, S; Uno, Y; Utoh, M; Yamazaki, H	1
Arakawa, H; Itoh, M; Kojima, H; Koyama, S; Masuda, N; Ogihara, T; Yano, K	1
Hakamata, A; Inui, N; Kamiya, C; Miyakawa, S; Namiki, N; Odagiri, K; Tanaka, S; Uchida, S; Watanabe, H	1
Crampton, AL; Khetani, SR; Kukla, DA; Wood, DK	1
Iwao, T; Koeda, A; Matsunaga, T; Mizuno, S; Nakamura, K; Nakanishi, A; Sakai, Y; Yamashita, M	1
Damanhuri, NS; Kumolosasi, E; Mansor, AH; Omar, MS; Razak, AFA	1
Alabanza, A; Lohmer, L; Patel, J; Schueller, O; Singh, N; Willson, A	1
Blank, A; Burhenne, J; Elbe, A; Foerster, KI; Haefeli, WE; Mikus, G; Rose, P	1
Aarnoutse, RE; Boeree, MJ; Coenen, MJH; Colbers, A; Dawson, R; Diacon, AH; Fuhr, U; Jager, Vd; Narunsky, K; Padayachee, SD; Phillips, PPJ; Stemkens, R; Svensson, EM; Te Brake, LHM; van Beek, SW	1
Murayama, N; Suemizu, H; Uehara, S; Uno, Y; Ushirozako, G; Yamazaki, H	1

Reviews

4 review(s) available for omeprazole and rifampin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example. Journal of medicinal chemistry, 2018, 09-13, Volume: 61, Issue:17 Topics: Drug Design; Drug Discovery; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fluorescence Polarization; Glutathione Transferase; Humans	2018
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells	2022
Drug-drug interactions with raltegravir. European journal of medical research, 2009, Nov-24, Volume: 14 Suppl 3 Topics: Antibiotics, Antitubercular; Antiviral Agents; Drug Interactions; Enzyme Inhibitors; HIV Infections; HIV Integrase Inhibitors; Humans; Omeprazole; Pyrrolidinones; Raltegravir Potassium; Rifampin	2009

Trials

6 trial(s) available for omeprazole and rifampin

Article	Year
Cytochrome P450 mRNA expression in peripheral blood lymphocytes as a predictor of enzyme induction. European journal of clinical pharmacology, 2005, Volume: 61, Issue:8 Topics: Adult; Caffeine; Cytochrome P-450 Enzyme System; Debrisoquin; Female; Gene Expression Regulation, Enzymologic; Humans; Leukocytes, Mononuclear; Male; Midazolam; Omeprazole; Rifampin; RNA, Messenger	2005
A double blind, randomised placebo controlled trial of rifampicin with omeprazole in the treatment of human cutaneous leishmaniasis. Journal of vector borne diseases, 2006, Volume: 43, Issue:4 Topics: Adolescent; Adult; Aged; Animals; Antiprotozoal Agents; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Leishmania tropica; Leishmaniasis, Cutaneous; Male; Middle Aged; Omeprazole; Rifampin; Treatment Outcome	2006
Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterol. Clinical pharmacology and therapeutics, 2008, Volume: 84, Issue:5 Topics: Adult; Anti-Ulcer Agents; Antibiotics, Antitubercular; Antihypertensive Agents; Antimalarials; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Drug Combinations; Enzyme Induction; Female; Humans; Hydroxycholesterols; Losartan; Male; Middle Aged; Omeprazole; Quinine; Rifampin	2008
Pharmacokinetic drug interactions involving vortioxetine (Lu AA21004), a multimodal antidepressant. Clinical drug investigation, 2013, Volume: 33, Issue:10 Topics: Adolescent; Adult; Antidepressive Agents; Antifungal Agents; Bupropion; Cohort Studies; Contraceptives, Oral, Hormonal; Cross-Over Studies; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Female; Fluconazole; Humans; Ketoconazole; Male; Middle Aged; Omeprazole; Piperazines; Rifampin; Single-Blind Method; Sulfides; Vortioxetine; Young Adult	2013
Drug-drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer. Drug design, development and therapy, 2017, Volume: 11 Topics: Adult; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Fluconazole; Healthy Volunteers; Humans; Male; Middle Aged; Omeprazole; Rifampin; Young Adult	2017
A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors. Clinical pharmacology in drug development, 2022, Volume: 11, Issue:7 Topics: Acetamides; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inducers; Drug Interactions; Humans; Itraconazole; Omeprazole; Protein Kinases; Proton Pump Inhibitors; Rabeprazole; Rifampin	2022

Other Studies

47 other study(ies) available for omeprazole and rifampin

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Adolescent; Adult; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Glucuronosyltransferase; Hepatocytes; Humans; Ketoconazole; Kinetics; Lung; Male; Microsomes, Liver; Middle Aged; Phenylacetates; Prostaglandins; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Young Adult	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery. Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7 Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics	2015
Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. Journal of medicinal chemistry, 2022, 03-24, Volume: 65, Issue:6 Topics: Anaerobiosis; DNA-Directed RNA Polymerases; Helicobacter Infections; Helicobacter pylori; Humans; Nitroimidazoles; Rifamycins	2022
Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology, 1990, Volume: 99, Issue:3 Topics: Aged; Benzoflavones; beta-Naphthoflavone; Blotting, Northern; Blotting, Western; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Half-Life; Humans; In Vitro Techniques; Liver; Male; Methylcholanthrene; Middle Aged; Omeprazole; Oxygenases; Rifampin; RNA, Messenger	1990
Effect of phenobarbital and other model inducers on cytochrome P450 isoenzymes in primary culture of dog hepatocytes. Xenobiotica; the fate of foreign compounds in biological systems, 1993, Volume: 23, Issue:6 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Benzoflavones; beta-Naphthoflavone; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dogs; Enzyme Induction; Isoenzymes; Kinetics; Liver; Male; Microsomes, Liver; Omeprazole; Oxidoreductases; Phenobarbital; Rifampin; Steroid 16-alpha-Hydroxylase	1993
Induction of cytochrome P450 3A (CYP 3A) by E 5110, a non-steroidal anti-inflammatory agent (NSAID), and typical CYP 3A inducers in primary cultures of dog hepatocytes. Biological & pharmaceutical bulletin, 1995, Volume: 18, Issue:8 Topics: 7-Alkoxycoumarin O-Dealkylase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbamazepine; Cells, Cultured; Clofibrate; Clotrimazole; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dogs; Drug Interactions; Enzyme Induction; Liver; Male; Mixed Function Oxygenases; Omeprazole; Phenobarbital; Phenytoin; Pyrrolidinones; Rifampin; Steroid Hydroxylases	1995
An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes. Chemico-biological interactions, 1998, Jul-03, Volume: 114, Issue:1-2 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Benzimidazoles; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Humans; Lansoprazole; Liver; Male; Methylcholanthrene; Middle Aged; Omeprazole; Pantoprazole; Rifampin; Steroid Hydroxylases; Structure-Activity Relationship; Sulfoxides	1998
Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog. Chemico-biological interactions, 2001, May-16, Volume: 134, Issue:3 Topics: Adult; Aged; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Dexamethasone; Dogs; Enzyme Induction; Female; Hepatocytes; Humans; Male; Middle Aged; Omeprazole; Rats; Rats, Sprague-Dawley; Rifampin; Species Specificity; Swine, Miniature	2001
Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2002, Volume: 122, Issue:5 Topics: Aged; Alcohol Dehydrogenase; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Hepatocytes; Humans; Omeprazole; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Sensitivity and Specificity	2002
A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system. The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1 Topics: Base Sequence; Blotting, Northern; Cell Line, Transformed; Cell Survival; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA Primers; Enzyme Induction; Genes, Reporter; Hepatocytes; Humans; Liver; Lovastatin; Luciferases; Mifepristone; Mixed Function Oxygenases; Omeprazole; Polychlorinated Dibenzodioxins; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Transcription, Genetic; Transfection	2002
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin	2005
Effects of prototypical drug-metabolizing enzyme inducers on mRNA expression of housekeeping genes in primary cultures of human and rat hepatocytes. Biochemical and biophysical research communications, 2006, Aug-04, Volume: 346, Issue:3 Topics: Adult; Aged; Animals; Cells, Cultured; Child, Preschool; Dexamethasone; Female; Gene Expression Regulation; Genes; Hepatocytes; Humans; Inactivation, Metabolic; Omeprazole; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Rifampin; RNA, Messenger	2006
Regulation of mRNA expression of MDR1, MRP1, MRP2 and MRP3 by prototypical microsomal enzyme inducers in primary cultures of human and rat hepatocytes. Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:4 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Dexamethasone; Enzyme Induction; Enzyme Inhibitors; Female; Gene Expression Regulation; Hepatocytes; Humans; Membrane Transport Proteins; Microsomes; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Omeprazole; Rats; Rats, Sprague-Dawley; Rifampin; RNA, Messenger; Transcription, Genetic	2006
Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes. Drug metabolism and pharmacokinetics, 2007, Volume: 22, Issue:3 Topics: Adult; Aged; Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Child, Preschool; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Female; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Macaca fascicularis; Male; Omeprazole; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger	2007
Systematic and simultaneous gene profiling of 84 drug-metabolizing genes in primary human hepatocytes. Journal of biomolecular screening, 2008, Volume: 13, Issue:3 Topics: Brain; Cells, Cultured; Gene Expression Profiling; Gene Expression Regulation; Hepatocytes; Humans; Inactivation, Metabolic; Methylcholanthrene; Omeprazole; Polymerase Chain Reaction; Principal Component Analysis; Rifampin; RNA	2008
Tuberculosis in a patient on temozolomide: a case report. Journal of neuro-oncology, 2009, Volume: 92, Issue:1 Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antibiotics, Antitubercular; Anticholesteremic Agents; Anticonvulsants; Antineoplastic Agents, Alkylating; Atorvastatin; Brain Neoplasms; Combined Modality Therapy; Cyclosporine; Dacarbazine; Dexamethasone; Female; Fluoxetine; Glioblastoma; Heptanoic Acids; Humans; Immunosuppressive Agents; Isoniazid; Middle Aged; Omeprazole; Phenobarbital; Prednisone; Pyrazinamide; Pyrroles; Radiotherapy; Red-Cell Aplasia, Pure; Rifampin; Temozolomide; Trimethoprim, Sulfamethoxazole Drug Combination; Tuberculosis, Pulmonary	2009
Comparison of inducibility of multidrug resistance (MDR)1, multidrug resistance-associated protein (MRP)1, and MRP2 mRNAs by prototypical microsomal enzyme inducers in primary cultures of human and cynomolgus monkey hepatocytes. Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:11 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cryopreservation; Dexamethasone; Enzyme Induction; Female; Hepatocytes; Humans; Macaca fascicularis; Microsomes, Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Omeprazole; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Species Specificity	2008
Follow-up to the pre-validation of a harmonised protocol for assessment of CYP induction responses in freshly isolated and cryopreserved human hepatocytes with respect to culture format, treatment, positive reference inducers and incubation conditions. Toxicology in vitro : an international journal published in association with BIBRA, 2010, Volume: 24, Issue:1 Topics: Adult; Aged; Antibiotics, Antitubercular; beta-Naphthoflavone; Cell Culture Techniques; Cell Separation; Cryopreservation; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; Follow-Up Studies; Hepatocytes; Humans; Indicators and Reagents; Isoenzymes; Male; Middle Aged; Omeprazole; Phenobarbital; Proton Pump Inhibitors; Reference Standards; Rifampin; RNA, Messenger; Young Adult	2010
Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:3 Topics: Cell Culture Techniques; Cell Differentiation; Cell Line, Transformed; Cells, Cultured; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Enzyme Induction; Gene Expression Regulation; Glucuronosyltransferase; Glutathione Transferase; Hepatocytes; Humans; Isoenzymes; Membrane Transport Proteins; Omeprazole; Phenobarbital; Receptors, Cytoplasmic and Nuclear; Reproducibility of Results; Rifampin; RNA, Messenger; Time Factors; Xenobiotics	2010
A newly developed DNA microarray is useful to assess induction of cytochromes p450 in the cynomolgus monkey. Drug metabolism and pharmacokinetics, 2011, Volume: 26, Issue:3 Topics: Animal Structures; Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Enzyme Induction; Gene Expression; Hepatocytes; Ileum; Isoenzymes; Jejunum; Kidney Cortex; Kidney Medulla; Liver; Macaca fascicularis; Male; Oligonucleotide Array Sequence Analysis; Omeprazole; Rifampin	2011
Assessment of a novel β2-adrenoceptor agonist, trantinterol, for interference with human liver cytochrome P450 enzymes activities. Toxicology in vitro : an international journal published in association with BIBRA, 2011, Volume: 25, Issue:5 Topics: Adrenergic Agonists; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Clenbuterol; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Interactions; Hepatocytes; Humans; Mass Spectrometry; Microsomes, Liver; Nonlinear Dynamics; Omeprazole; Rifampin	2011
Expression of albumin and cytochrome P450 enzymes in HepG2 cells cultured with a nanotechnology-based culture plate with microfabricated scaffold. The Journal of toxicological sciences, 2011, Volume: 36, Issue:5 Topics: Albumins; CCAAT-Enhancer-Binding Protein-alpha; Cell Culture Techniques; Cell Survival; Cytochrome P-450 Enzyme System; Enzyme-Linked Immunosorbent Assay; Hep G2 Cells; Hepatocyte Nuclear Factor 4; Humans; Microtechnology; Nanotechnology; Omeprazole; Real-Time Polymerase Chain Reaction; Rifampin	2011
Chronological effects of rifampicin discontinuation on cytochrome P450 activity in healthy Japanese volunteers, using the cocktail method. Clinical pharmacology and therapeutics, 2013, Volume: 94, Issue:6 Topics: Adult; Antibiotics, Antitubercular; Asian People; Caffeine; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Imidazoles; Losartan; Male; Midazolam; Omeprazole; Rifampin; Tetrazoles; Theophylline; Time Factors; Withholding Treatment	2013
Aggregate culture of human embryonic stem cell-derived hepatocytes in suspension are an improved in vitro model for drug metabolism and toxicity testing. Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 140, Issue:1 Topics: Acetaminophen; Cell Aggregation; Cell Culture Techniques; Cell Differentiation; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Drug Discovery; Embryonic Stem Cells; Enzyme Induction; Hep G2 Cells; Hepatocytes; Humans; Omeprazole; Pluripotent Stem Cells; Rifampin; Tandem Mass Spectrometry; Toxicity Tests	2014
3D spheroid cultures improve the metabolic gene expression profiles of HepaRG cells. Bioscience reports, 2015, May-07, Volume: 35, Issue:3 Topics: Albumins; Apolipoproteins B; Cell Culture Techniques; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Glucose; Hep G2 Cells; High-Throughput Screening Assays; Humans; Lipid Metabolism; Lipoproteins, LDL; Liver; Omeprazole; Phenobarbital; Rifampin; Spheroids, Cellular; Transcriptome	2015
Strong Induction of Cytochrome P450 1A/3A, But not P450 2B, in Cultured Hepatocytes from Common Marmosets and Cynomolgus Monkeys by Typical Human P450 Inducing Agents. Drug metabolism letters, 2017, Volume: 10, Issue:4 Topics: Animals; Callithrix; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inducers; Drug Evaluation, Preclinical; Drug Interactions; Feasibility Studies; Hepatocytes; Humans; Macaca fascicularis; Male; Models, Animal; Omeprazole; Phenobarbital; Reverse Transcriptase Polymerase Chain Reaction; Rifampin	2017
Influences of proton pump inhibitor on Helicobacter pylori adherence to the gastrointestinal cell lines. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2017, Volume: 28, Issue:1 Topics: Antibiotics, Antitubercular; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bacterial Adhesion; Caco-2 Cells; Esomeprazole; Helicobacter pylori; Humans; Omeprazole; Proton Pump Inhibitors; Rifampin; Time Factors	2017
Effects of aging and rifampicin pretreatment on the pharmacokinetics of human cytochrome P450 probes caffeine, warfarin, omeprazole, metoprolol and midazolam in common marmosets genotyped for cytochrome P450 2C19. Xenobiotica; the fate of foreign compounds in biological systems, 2018, Volume: 48, Issue:7 Topics: Administration, Intravenous; Aging; Animals; Caffeine; Callithrix; Cytochrome P-450 CYP2C19; Genotype; Humans; Male; Metoprolol; Midazolam; Omeprazole; Rifampin; Substrate Specificity; Warfarin	2018
Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates. Biopharmaceutics & drug disposition, 2018, Volume: 39, Issue:4 Topics: Acetaminophen; Adenosine Triphosphate; Arylsulfotransferase; Cell Culture Techniques; Cells, Cultured; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Diclofenac; Glucuronosyltransferase; Hepatocytes; Humans; Lamotrigine; Midazolam; Omeprazole; Rifampin; RNA, Messenger; Triazines	2018
Effect of co-administered inducer or inhibitor on omeprazole pharmacokinetics based on CYP2C19 genotype. Journal of pharmacological sciences, 2019, Volume: 139, Issue:4 Topics: Adult; Alleles; Cytochrome P-450 CYP2C19; Drug Interactions; Fluvoxamine; Genetic Association Studies; Genotype; Humans; Male; Omeprazole; Proton Pump Inhibitors; Rifampin; Young Adult	2019
Microscale Collagen and Fibroblast Interactions Enhance Primary Human Hepatocyte Functions in Three-Dimensional Models. Gene expression, 2020, 06-12, Volume: 20, Issue:1 Topics: 3T3 Cells; Animals; Cell Encapsulation; Cells, Cultured; Coculture Techniques; Collagen Type I; Cytochrome P-450 Enzyme System; Enzyme Induction; Gels; Gene Expression; Hepatic Stellate Cells; Hepatocytes; Humans; Lab-On-A-Chip Devices; Mice; Omeprazole; Polymerization; Rifampin; Spheroids, Cellular; Tissue Engineering	2020
Comparison of the inducibility of CYP mRNA exposed to typical inducers in fresh and cryopreserved cynomolgus monkey hepatocytes. Drug metabolism and pharmacokinetics, 2020, Volume: 35, Issue:3 Topics: Animals; Cell Survival; Cells, Cultured; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Hepatocytes; Liver; Macaca fascicularis; Male; Omeprazole; Phenobarbital; Rifampin; RNA, Messenger	2020
The influence of P-glycoprotein expression in the standard treatment of Helicobacter pylori infection in Sprague Dawley rats. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2021, Volume: 29, Issue:1 Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clarithromycin; Cyclosporine; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; Male; Omeprazole; Proton Pump Inhibitors; Rats, Sprague-Dawley; Rifampin; Stomach Ulcer	2021
Evaluation of CYP2C19 activity using microdosed oral omeprazole in humans. European journal of clinical pharmacology, 2022, Volume: 78, Issue:6 Topics: Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Drug Interactions; Fluconazole; Humans; Midazolam; Omeprazole; Rifampin; Sodium Bicarbonate; Yohimbine	2022
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis. Antimicrobial agents and chemotherapy, 2023, 10-18, Volume: 67, Issue:10 Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Humans; Midazolam; Omeprazole; Rifampin; Tolbutamide; Tuberculosis, Pulmonary	2023
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation. Xenobiotica; the fate of foreign compounds in biological systems, 2023, Volume: 53, Issue:6-7 Topics: Animals; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dogs; Hepatocytes; Humans; Hydroxylation; Microsomes, Liver; Omeprazole; Rifampin	2023