omeprazole has been researched along with indomethacin in 146 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (10.27) | 18.7374 |
| 1990's | 40 (27.40) | 18.2507 |
| 2000's | 51 (34.93) | 29.6817 |
| 2010's | 33 (22.60) | 24.3611 |
| 2020's | 7 (4.79) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bharate, SS; Vishwakarma, RA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M | 1 |
| Carter, KJ; Goddard, PJ; Silen, W; Yanaka, A | 1 |
| Brzozowski, T; Garlicki, J; Konturek, SJ; Majka, J; Nauert, C; Stachura, J | 1 |
| Akimoto, Y; Kuwahara, K; Okabe, S; Yamasaki, S | 1 |
| Aihara, H; Arai, I; Hirose-Kijima, H; Isobe, Y; Muramatsu, M; Nagai, H; Otomo, S; Usuki-Ito, C | 1 |
| Hirose, H; Okabe, S; Takeuchi, K | 1 |
| Bezabah, S; Erickson, RA; Jonas, G; Lifrak, E; Tarnawski, AS | 1 |
| Nagai, H; Okabe, S; Wang, JY | 1 |
| Furukawa, O; Niida, H; Okabe, S; Okada, M; Takeuchi, K | 1 |
| Arisawa, T; Goto, H; Hase, S; Kawabe, Y; Kuroiwa, M; Nakazawa, S; Osada, T; Segawa, K; Tsuchida, T; Tsukamoto, Y | 1 |
| Miyake, H; Okabe, S; Yamasaki, S | 1 |
| Ivey, KJ; Razandi, M; Romano, M | 1 |
| Niida, H; Okabe, S; Okada, M; Takeuchi, K | 1 |
| Hara, K; Higaki, E; Higuchi, T; Okabe, S; Sato, M | 1 |
| Dammann, HG; Müller, P; Simon, B | 1 |
| Fukui, A; Goto, H; Nakazawa, S; Ozawa, T; Sugiyama, S | 1 |
| Gilbertson, SK; Kolbasa, KP; Lancaster, C; Olafsson, AS; Robert, A | 1 |
| Evangelista, S; Ghelardoni, M; Meli, A; Pestellini, V; Viti, G | 1 |
| Baumgartner, A; Halter, F; Inauen, W; Kayser, S; Koelz, HR; Schürer-Maly, CC; Wyss, PA | 1 |
| Katsuyama, Y; Watanabe, K; Yano, S | 1 |
| Furukawa, O; Nishiwaki, H; Okabe, S; Takeuchi, K | 1 |
| Awane, Y; Miyake, H; Okabe, S | 1 |
| Haag, K; Knauf, H | 1 |
| Okabe, S; Okada, Y; Yamamoto, O | 1 |
| Flogerzi, B; Halter, F; Peskar, BM; Schmassmann, A; Tarnawski, A; Varga, L | 1 |
| Arcari, ML; Bertaccini, G; Grandi, D; Morini, G | 2 |
| Arakawa, T; Fukuda, T; Higuchi, K; Kobayashi, K; Ohtani, K; Shimizu, Y | 1 |
| Okabe, S; Takeuchi, K | 1 |
| Batten, JJ; Calam, J; Calnan, DP; Hansen, HF; Marchbank, T; Playford, RJ; Royston, P | 1 |
| Akuzawa, S; Ito, H; Kamato, T; Kobayashi, A; Miyata, K; Nagakura, Y; Nishida, A; Takinami, Y; Yamano, M; Yuki, H | 1 |
| Kamishiro, T; Masuda, M; Matsukura, H; Uchida, A | 1 |
| Aihara, K; Kogi, K; Narita, S; Yamada, S; Yamaguchi, T | 1 |
| Inoue, K; Okabe, S; Takagi, K | 1 |
| Kato, S; Okabe, S; Takeuchi, K | 2 |
| Taché, Y; Yoneda, M | 1 |
| Diwan, PV; Krishna, DR; Sastry, MS | 1 |
| Cook, GA; Elliott, SL; Ferris, RJ; Giraud, AS; Skeljo, MV; Yeomans, ND | 1 |
| Nozue, C; Okabe, S; Tsukimi, Y | 1 |
| Amagase, K; Kato, S; Okabe, S; Yamamoto, H | 1 |
| Feldman, M; Kallal, SM; Lee, M | 1 |
| Okabe, S; Takahashi, S | 1 |
| Asano, S; Inatomi, N; Murakami, I; Nagaya, H; Satoh, H; Yukishige, K | 1 |
| Okabe, S; Takahashi, S; Yamazaki, T | 1 |
| Hirata, T; Kato, S; Takeuchi, K | 1 |
| Piotrowski, J; Slomiany, A; Slomiany, BL | 2 |
| Evangelista, S | 1 |
| Chiba, T; Fukui, H; Hassan, MS; Kawamura, M; Kinoshita, Y; Kishi, K; Maekawa, T; Matsushima, Y; Okada, A; Waki, S | 1 |
| Bianchi Porro, G; Caruso, I; Lazzaroni, M; Manzionna, G; Montrone, F; Petrillo, M | 1 |
| Chang, MS; Choi, WS; Chung, YK; Kim, KB; Kim, SG; Sohn, SK | 1 |
| Chang, MS; Choi, WS; Chung, YK; Kim, KB; Kim, SG; Sohn, SK; Wook, TW | 1 |
| Aralica, G; Desković, S; Grabarević, Z; Jadrijević, S; Konjevoda, P; Marović, A; Perović, D; Petek, M; Rucman, R; Seiwerth, S; Sikirić, P; Sosa, T; Turković, B | 1 |
| Impicciatore, M; Letari, O; Makovec, F; Mennuni, L; Revel, L | 1 |
| Arakawa, T; Higuchi, K; Kobayashi, K; Kuroki, T; Takaishi, O; Yamasaki, K | 1 |
| Arroyo, MT; Lanas, A; Sáinz, R | 1 |
| Arakawa, T; Fujiwara, Y; Higuchi, K; Tominaga, K; Watanabe, T | 1 |
| Bandyopadhyay, D; Bandyopadhyay, U; Banerjee, RK; Biswas, K; Reiter, RJ | 1 |
| Denaro, MG; Faggio, C; Lionetto, MG; Trischitta, F | 1 |
| Cheon, HG; Lee, DH; Lee, SS; Lim, H | 1 |
| Anic, T; Aralica, G; Bilic, I; Buljat, G; Ivankovic, D; Mikus, D; Mise, S; Perovic, D; Petek, M; Prkacin, I; Rotkvic, I; Rucman, R; Seiwerth, S; Separovic, J; Sikiric, P; Stancic-Rokotov, D; Zoricic, I | 1 |
| Almeida, AB; Brasil, DS; Gracioso, JS; Hiruma-Lima, CA; Muller, AH; Paula, AC; Souza Brito, AR; Toma, W | 1 |
| Kato, S; Kunikata, T; Ogawa, Y; Takeuchi, K; Tanaka, A | 1 |
| Blandizzi, C; Del Tacca, M; Gherardi, G; Lazzeri, G; Lenzi, P; Natale, G; Pellegrini, A | 1 |
| Cetin, A; Kaya, T; Sarioglu, Y; Yildirim, K; Yildirim, S | 1 |
| Amagase, K; Itoh, S; Nakai, H; Okabe, S; Tsukimi, Y | 1 |
| Ebata, M; Keto, Y; Okabe, S | 1 |
| Akcay, MF; Banoglu, ZN; Büyükokuroglu, ME; Demirezer, LO; Gepdiremen, A; Göçer, F; Süleyman, H | 1 |
| Bastaki, SM; Chandranath, SI; Singh, J | 1 |
| Ebata, M; Keto, Y; Okabe, S; Tomita, K | 1 |
| Di Stasi, LC; Gonzalez, FG | 1 |
| Kelicen, P; Pekiner, C; Sarioğlu, Y; Uma, S | 1 |
| Adami, M; Brenciaglia, MI; Cena, C; Coruzzi, G; Dubini, F; Fruttero, R; Galli, U; Gasco, A; Morini, G; Sorba, G | 1 |
| Helander, HF; Poorkhalkali, N | 1 |
| Batista, LM; Calvo, TR; de Almeida, AB; de Pietro Magri, L; Souza Brito, AR; Toma, W; Vilegas, W | 1 |
| Hayashi, Y; Kubo, Y; Takeuchi, K; Tanaka, A | 1 |
| Arakawa, T; Fujiwara, Y; Hamaguchi, M; Higuchi, K; Matsumoto, T; Shiba, M; Tominaga, K; Watanabe, T | 1 |
| Bai, KL; Choi, HJ; Ham, I; Jeong, JH; Min, YS; Park, SY; Sohn, UD; Song, HJ; Whang, WK; Yim, SH | 1 |
| Abramo, A; Antonioli, L; Baldi, S; Blandizzi, C; Carazzina, G; Colucci, R; Del Tacca, M; Fornai, M; Lubrano, V; Natale, G; Tuccori, M | 1 |
| Ahn, BO; Choi, SM; Kim, DH; Kim, JM; Kim, WB; Kwon, JW; Oh, TY | 1 |
| Dömötör, A; Hideg, K; Hunyady, B; Karádi, O; Mózsik, G; Peidl, Z; Szekeres, G; Szolcsányi, J | 1 |
| Ichikawa, H; Kuroda, M; Naito, Y; Okanoue, T; Okuda, T; Takagi, T; Yoshida, N; Yoshikawa, T | 1 |
| Arisawa, T; Fujita, H; Harata, M; Hasegawa, S; Kamiya, Y; Mizuno, T; Nagasaka, M; Nakamura, M; Nakano, H; Ohta, Y; Shibata, T; Tahara, T | 1 |
| Bai, KL; Ham, I; Kim, JH; Lee, YJ; Min, YS; Sohn, UD; Song, HJ; Whang, WK; Yim, SH | 1 |
| Bertini, S; Cavestro, GM; Coruzzi, G; Grandi, D; Menozzi, A; Ossiprandi, MC; Pozzoli, C; Solenghi, E; Zullian, C | 1 |
| Matsuda, H; Nagatomo, A; Ochi, M; Yoshikawa, M | 1 |
| Comunello, E; de Andrade, SF; Filho, VC; Lemos, M; Niero, R; Noldin, VF | 1 |
| Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Maity, B | 1 |
| Bandyopadhyay, SK; Banerjee, D; Bauri, AK; Chattopadhyay, S; Guha, RK | 1 |
| Atamanalap, SS; Aydinli, B; Başoğlu, M; Gündoğdu, C; Gürsan, N; Kiziltunç, A; Oren, D; Oztürk, G; Polat, KY; Süleyman, H; Yildirgan, MI | 1 |
| Bastaki, SM; Chandranath, IS; Singh, J | 1 |
| Bandivdeker, AH; Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B | 1 |
| Andersson, M; Arvidsson, A; Brevinge, H; Lagerstedt, K; Lönnroth, C; Lundholm, K; Nordgren, S | 1 |
| Bandyopadhyay, SK; Banerjee, D; Bhattacharya, S; Chattopadhyay, S | 1 |
| Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Maity, B | 2 |
| Alves, CC; Barbosa, NR; Dutra, RC; Fava, MB; Ferreira, AP | 1 |
| Araújo, JH; Dal-Pizzol, F; Ferreira, GK; Petronilho, F; Rezin, GT; Roesler, R; Schwartsmann, G; Steckert, AV; Streck, EL | 1 |
| Andrade, SF; Becker, RG; Berté, TE; Cechinel-Filho, V; Delle-Monache, F; Meyre-Silva, C; Petry, CM; Zanatta, F | 1 |
| Apikoglu-Rabus, S; Cevikbas, U; Izzettin, FV; Okuyan, B; Sancar, M | 1 |
| Araújo, JH; Cardoso, MR; Dal-Pizzol, F; Daufenbach, JF; Gonçalves, CL; Petronilho, FC; Rezin, GT; Roesler, R; Schwartsmann, G; Streck, EL | 1 |
| Adhikary, B; Bandyopadhyay, SK; Chand, S; Chattopadhyay, S; Yadav, SK | 1 |
| Adhikary, B; Bandyopadhyay, SK; Chattopadhyay, S; Yadav, SK | 2 |
| Bandyopadhyay, SK; Banerjee, D; Chattopadhyay, S; Hassarajani, SA; Maity, B; Narayan, G | 1 |
| Abdul Hisam, EE; Hasiah, AH; Norhafizah, M; Othman, F; Rofiee, MS; Vasudevan, M; Zakaria, ZA | 1 |
| Dial, EJ; Graham, DY; Lichtenberger, LM; Lim, YJ; Phan, TM | 1 |
| Czimmer, J; Mózsik, G; Szabó, IL; Szolcsányi, J | 1 |
| Hamid, HA; Hisam, EE; Mohtaruddin, N; Othman, F; Rofiee, MS; Zakaria, ZA | 1 |
| Andreeva, IuV; Khropycheva, RP; Zolotarev, VA | 1 |
| Castañeda-Hernández, G; Chávez-Piña, AE; Jiménez-Andrade, JM; Pineda-Peña, EA | 1 |
| Angioli, R; Damiani, P; Improta, G; Petrella, C; Plotti, F; Scarpignato, C; Severini, C; Signore, F; Terranova, C | 1 |
| Baracho, NC; Irulegui, Rde S; Pereira, RM; Ribeiro, RV | 1 |
| Adewoye, EO; Salami, AT | 1 |
| He, BS; Mi, QY; Pan, YQ; Tai, T; Xie, HG; Zhao, SL | 1 |
| Bhattarai, D; Dial, EJ; Lichtenberger, LM; Phan, TM; Uray, K | 1 |
| Andreeva, YV; Kropycheva, RP; Vershinina, EA; Zolotarev, VA | 1 |
| El-Ashmawy, NE; El-Bahrawy, HA; Khedr, EG; Selim, HM | 1 |
| Andreeva, YV; Khropycheva, RP; Vershinina, E; Zolotarev, VA | 1 |
| Chen, SJ; Fang, YF; Lian, QW; Qiu, LF; Wang, L; Xu, WL; Zhou, H | 1 |
| He, HB; He, YM; Li, XM; Li, XQ; Qin, HL; Wang, JZ; Xiong, XJ; Zhang, YF; Zou, K | 1 |
| Akiba, Y; Satoh, H; Urushidani, T | 1 |
| Bellile, E; Liu, S; McHugh, JB; Nguyen, A; Rozek, L; Sartor, M; Thomas, D; Wolf, GT; Zarins, K | 1 |
| Castañeda-Hernández, G; Chávez-Piña, AE; Méndez-Cruz, F; Pineda-Peña, EA; Rivera-Espinoza, Y; Sánchez-Trigueros, MI | 1 |
| AbdelAziz, EY; Menze, ET; Tadros, MG | 1 |
| Affuso, F; Bellavite, P; Fazio, S; McCullough, PA; Pandolfi, S; Zanolin, E | 1 |
| Cheng, X; Han, T; Jin, R; Li, J; Li, K | 1 |
3 review(s) available for omeprazole and indomethacin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Pharmacological study on the pathological changes of the gastric mucosa in Helicobacter pylori-infected Mongolian gerbils].
Topics: Adenocarcinoma; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Clarithromycin; Disease Models, Animal; Gastric Mucosa; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Indomethacin; Omeprazole; Recurrence; Stomach Neoplasms; Stomach Ulcer | 2001 |
Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced gastric mucosal damage in human healthy subjects (mini review).
Topics: Adult; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Atropine; Capsaicin; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Female; Gastric Acid; Gastric Mucosa; Humans; Indomethacin; Male; Omeprazole; Peptic Ulcer; Ranitidine | 2013 |
5 trial(s) available for omeprazole and indomethacin
| Article | Year |
|---|---|
[Stomach tolerance of nonsteroidal antirheumatic drugs: comparative endoscopic study].
Topics: Adult; Alprostadil; Antacids; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Gastroscopy; Humans; Indomethacin; Misoprostol; Omeprazole; Prostaglandins E; Ranitidine; Rioprostil; Stomach Ulcer | 1987 |
Prevention of gastroduodenal damage with omeprazole in patients receiving continuous NSAIDs treatment. A double blind placebo controlled study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Double-Blind Method; Endoscopy, Digestive System; Female; Follow-Up Studies; Gastric Mucosa; Humans; Indomethacin; Intestinal Mucosa; Ketoprofen; Male; Middle Aged; Omeprazole; Peptic Ulcer; Rheumatic Diseases; Safety; Treatment Outcome | 1998 |
Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Movement; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dendritic Cells; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HLA-D Antigens; Humans; Indomethacin; Lymphocyte Subsets; Lymphocytes, Tumor-Infiltrating; Macrophages; Male; Middle Aged; Neoplasm Proteins; Omeprazole; Premedication; Preoperative Care; Pyrazoles; Sulfonamides | 2008 |
Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced gastric mucosal damage in human healthy subjects (mini review).
Topics: Adult; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Atropine; Capsaicin; Cimetidine; Dose-Response Relationship, Drug; Famotidine; Female; Gastric Acid; Gastric Mucosa; Humans; Indomethacin; Male; Omeprazole; Peptic Ulcer; Ranitidine | 2013 |
Tumor infiltrating lymphocytes after neoadjuvant IRX-2 immunotherapy in oral squamous cell carcinoma: Interim findings from the INSPIRE trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antineoplastic Agents, Alkylating; B7-H1 Antigen; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclin-Dependent Kinase Inhibitor p16; Cyclophosphamide; Cytokines; Female; Humans; Immunosuppressive Agents; Immunotherapy; Indomethacin; Lymphocyte Count; Lymphocytes, Tumor-Infiltrating; Male; Middle Aged; Mouth Neoplasms; Neoadjuvant Therapy; Omeprazole; Squamous Cell Carcinoma of Head and Neck; Tissue Array Analysis; Zinc | 2020 |
139 other study(ies) available for omeprazole and indomethacin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship | 2003 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics | 2015 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries | 2023 |
Prostaglandin stimulates Cl(-)-HCO3- exchange in amphibian oxynticopeptic cells.
Topics: Animals; Carrier Proteins; Chloride-Bicarbonate Antiporters; Electrophysiology; Gastric Fundus; Homeostasis; Hydrochloric Acid; Hydrogen; Hydrogen-Ion Concentration; Indomethacin; Omeprazole; Parietal Cells, Gastric; Prostaglandins; Rana catesbeiana; Rest | 1992 |
Intragastric pH in the gastroprotective and ulcer-healing activity of aluminum-containing antacids.
Topics: Acute Disease; Aluminum Hydroxide; Animals; Antacids; Chronic Disease; Drug Combinations; Ethanol; Female; Gastric Acid; Gastric Mucosa; Hydrogen-Ion Concentration; Indomethacin; Magnesium Hydroxide; Male; Omeprazole; Ranitidine; Rats; Rats, Inbred Strains; Stomach Ulcer | 1991 |
Effects of a new benzimidazole derivative, NC-1300-O-3, on gastric secretion and gastroduodenal lesions in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Benzimidazoles; Dogs; Duodenal Ulcer; Female; Gastric Mucosa; Histamine; Immersion; In Vitro Techniques; Indomethacin; Male; Omeprazole; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Psychological | 1991 |
Effects of the new H2-receptor antagonist 3-amino-4-[4- [4- (1-piperidinomethyl)-2-pyridyloxy]-cis-2-butenylamino]-3-cyclobutene-1, 2- dione hydrochloride on gastric acid secretion and ulceration.
Topics: Animals; Anti-Ulcer Agents; Cold Temperature; Cysteamine; Duodenal Ulcer; Gastric Acid; Histamine; Histamine H2 Antagonists; Indomethacin; Male; Omeprazole; Piperidines; Pylorus; Pyridines; Rats; Rats, Inbred Strains; Stomach Ulcer; Stress, Physiological | 1990 |
Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats.
Topics: Acetates; Acetic Acid; Animals; Dinoprostone; Gastric Mucosa; Indomethacin; Male; Omeprazole; Rats; Regional Blood Flow; Stomach Ulcer; Wound Healing | 1991 |
Chronic omeprazole treatment increases duodenal susceptibility to ethanol injury in rats.
Topics: Animals; Dinoprostone; Drug Synergism; Duodenum; Ethanol; Gastric Mucosa; Indomethacin; Male; Omeprazole; Rats; Rats, Inbred Strains | 1991 |
Effect of omeprazole on delayed healing of acetic acid-induced gastric ulcers in rats.
Topics: Acetates; Acetic Acid; Animals; Drug Therapy, Combination; Gastric Acid; Histamine; Indomethacin; Male; Omeprazole; Rats; Stomach Ulcer; Time Factors; Wound Healing | 1990 |
Influences of stress on gastric alkaline secretion in rats.
Topics: Animals; Gastric Acidity Determination; Gastric Mucosa; Immersion; Indomethacin; Male; Omeprazole; Quinacrine; Rats; Rats, Inbred Strains; Stress, Physiological; Vasopressins | 1990 |
The role of prostaglandin D2 in the genesis of indomethacin-induced gastric lesions in rats.
Topics: Animals; Biomechanical Phenomena; Gastric Mucosa; Indomethacin; Male; Omeprazole; Prostaglandin D2; Prostaglandins; Rats; Rats, Inbred Strains; Stomach; Stomach Ulcer | 1989 |
Effects of NC-1300, a gastric proton pump inhibitor, on healing of acetic acid-induced gastric ulcers in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Administration, Oral; Animals; Anti-Ulcer Agents; Benzimidazoles; Indomethacin; Male; Omeprazole; Rats; Stomach Ulcer | 1989 |
Protection of gastric epithelial cell monolayers from a human cell line by omeprazole in vitro.
Topics: Cell Line; Chromium Radioisotopes; Dinoprostone; Drug Evaluation; Gastric Acid; Gastric Mucosa; Humans; In Vitro Techniques; Indomethacin; Omeprazole; Sulfhydryl Compounds; Taurocholic Acid | 1989 |
Healing process of duodenal ulcers induced by indomethacin plus histamine in rats.
Topics: Animals; Cimetidine; Disease Models, Animal; Duodenal Ulcer; Duodenum; Gastric Acid; Histamine; Hydrogen-Ion Concentration; Indomethacin; Male; Omeprazole; Propantheline; Rats; Rats, Inbred Strains | 1989 |
Biochemical and pharmacological analysis of 2-[(2-dimethylaminobenzyl)sulfinyl] benzimidazole (NC-1300), a new proton pump inhibitor.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetylcholine; Adenosine Triphosphatases; Animals; Anti-Ulcer Agents; Aspirin; Benzimidazoles; Duodenum; Gastric Mucosa; Guinea Pigs; H(+)-K(+)-Exchanging ATPase; Heart Rate; Histamine; Ileum; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Omeprazole; Peptic Ulcer; Rabbits; Rats; Stress, Physiological | 1986 |
Effects of prostaglandin D2 and omeprazole on indomethacin-induced gastric ulcers in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Omeprazole; Peptic Ulcer; Prostaglandin D2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Inbred Strains | 1988 |
Indomethacin-induced gastric antral ulcers in hamsters.
Topics: Administration, Oral; Animals; Aspirin; Cimetidine; Cricetinae; Dinoprostone; Disease Models, Animal; Gastric Acid; Indomethacin; Injections, Subcutaneous; Male; Mesocricetus; Omeprazole; Peptic Ulcer Perforation; Prostaglandins E; Stomach Ulcer; Time Factors | 1988 |
[Synthesis and anti-ulcer activity of some new compounds with arylthiomethyl-pyridine structure].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Indomethacin; Male; Omeprazole; Pyridines; Rats; Rats, Inbred Strains; Stomach Ulcer | 1988 |
Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Autoradiography; Body Weight; Gastric Mucosa; Gastrins; Indomethacin; Male; Omeprazole; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Stomach Ulcer | 1988 |
Reduction of rat gastric transmucosal potential difference by indomethacin partly associated with its acid secretory activity.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Benzimidazoles; Dinoprostone; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Omeprazole; Prostaglandins E; Rats; Rats, Inbred Strains | 1986 |
Cytoprotective action of histamine against 0.6 N HCl-induced gastric mucosal injury in rats; comparative study with adaptive cytoprotection induced by exogenous acid.
Topics: Adaptation, Physiological; Animals; Cimetidine; Gastric Acid; Gastric Mucosa; Histamine; Hydrochloric Acid; Indomethacin; Male; Membrane Potentials; Omeprazole; Rats; Rats, Inbred Strains | 1987 |
Cytoprotective effects of NC-1300 and omeprazole on Hcl . ethanol-induced gastric lesions in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Ethanol; Ethylmaleimide; Gastric Juice; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Male; Omeprazole; Rats; Rats, Inbred Strains; Stomach Ulcer; Sulfones | 1986 |
Modelling of colonic Cl- and K+ transport under resting and secreting conditions.
Topics: Alprostadil; Animals; Biological Transport; Chlorides; Colon; Diuretics; Indomethacin; Intestinal Mucosa; Male; Membrane Potentials; Models, Biological; Omeprazole; Potassium; Rats; Rats, Inbred Strains | 1986 |
Effects of a proton pump inhibitor, omeprazole, on gastric secretion and gastric and duodenal ulcers or erosions in rats.
Topics: Animals; Aspirin; Benzimidazoles; Chemical Phenomena; Chemistry; Duodenal Ulcer; Epirizole; Gastric Juice; Indomethacin; Male; Omeprazole; Prednisolone; Rats; Rats, Inbred Strains; Stomach Ulcer | 1984 |
Influence of acid and angiogenesis on kinetics of gastric ulcer healing in rats: interaction with indomethacin.
Topics: Animals; Bromodeoxyuridine; Drug Combinations; Female; Fibroblast Growth Factor 2; Gastric Acid; Gastric Mucosa; Gastrins; Gastroscopy; Indomethacin; Kinetics; Neovascularization, Pathologic; Omeprazole; Prostaglandins; Rats; Rats, Wistar; Stomach Ulcer; Wound Healing | 1995 |
Gastroprotective activity of the novel proton pump inhibitor lansoprazole in the rat.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Mucosa; Indomethacin; Lansoprazole; Male; Omeprazole; Proton Pumps; Rats; Saline Solution, Hypertonic; Sodium-Potassium-Exchanging ATPase; Stomach Ulcer | 1995 |
Effects of lansoprazole on ethanol-induced injury and PG synthetic activity in rat gastric mucosa.
Topics: 16,16-Dimethylprostaglandin E2; 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Ethanol; Gastric Mucosa; Indomethacin; Lansoprazole; Male; Omeprazole; Prostaglandins; Proton Pump Inhibitors; Rats; Rats, Wistar; Stomach Ulcer | 1995 |
Mechanism of gastric alkaline response in the stomach after damage. Roles of nitric oxide and prostaglandins.
Topics: Animals; Arginine; Bicarbonates; Dinoprostone; Gastric Acid; Gastric Mucosa; Hydrogen-Ion Concentration; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Omeprazole; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic | 1995 |
Epidermal growth factor is digested to smaller, less active forms in acidic gastric juice.
Topics: Achlorhydria; Acids; Animals; Bicarbonates; Digestion; Drug Stability; Epidermal Growth Factor; Female; Gastric Juice; Humans; Indomethacin; Liver; Male; Omeprazole; Pepsin A; Rats; Rats, Wistar; Recombinant Proteins; Stomach; Thymidine | 1995 |
YM022 [(R)-1-[2,3-dihydro-1-(2'-methylphenacyl)-2-oxo-5-phenyl- 1H-1,4-benzodiazepin-3-yl]-3-(3-methylphenyl)urea], a potent and selective gastrin/cholecystokinin-B receptor antagonist, prevents gastric and duodenal lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepines; Duodenal Ulcer; Epirizole; Ethanol; Famotidine; Gastric Acid; Gastric Mucosa; Hydrogen-Ion Concentration; Indomethacin; Male; Omeprazole; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Stomach Ulcer; Stress, Physiological | 1994 |
Effects of NC-1300-O-3 on gastric mucus secretion and prostaglandin release in rats.
Topics: Animals; Anti-Ulcer Agents; Benzimidazoles; Cimetidine; Dinoprostone; Gastric Mucosa; Hexosamines; Hexoses; Indomethacin; Male; Mucus; Omeprazole; Prostaglandins; Rats; Rats, Sprague-Dawley | 1994 |
Biochemical and pharmacological properties of a newly synthesized proton pump (H+/K(+)-ATPase) inhibitor, TY-11345 in experimental animals.
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Benzimidazoles; Duodenal Ulcer; Epirizole; Ethanol; Gastric Mucosa; Immersion; In Vitro Techniques; Indomethacin; Male; Microsomes; Omeprazole; Proton Pump Inhibitors; Rabbits; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Stress, Psychological; Tetragastrin | 1993 |
Effect of NC-1300-O-3 on healing of acetic acid-induced gastric ulcers in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Benzimidazoles; Gastric Acid; Gastric Mucosa; Histamine; Indomethacin; Male; Omeprazole; Rats; Rats, Inbred Strains; Stomach Ulcer | 1993 |
Mechanism by which histamine increases gastric mucosal blood flow in the rat. Role of luminal H+.
Topics: Animals; Bicarbonates; Cimetidine; Drug Interactions; Gastric Acid; Gastric Mucosa; Glycine; Histamine; Hydrochloric Acid; Hydrogen; Indomethacin; Infusions, Intravenous; Male; Omeprazole; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sodium; Sodium Bicarbonate; Tripelennamine | 1993 |
Vagal regulation of gastric prostaglandin E2 release by central TRH in rats.
Topics: Animals; Brain; Dinoprostone; Extracellular Space; Gastric Acid; Gastric Mucosa; Indomethacin; Injections, Intraventricular; Male; Omeprazole; Pyrrolidonecarboxylic Acid; Rats; Thyrotropin-Releasing Hormone; Vagotomy; Vagus Nerve | 1993 |
Comparative evaluation of ulcer prevention efficacy of orally, rectally and sublingually administered omeprazole in three acute gastric ulcer models in rats.
Topics: Administration, Oral; Administration, Rectal; Administration, Sublingual; Animals; Aspirin; Female; Hydrochloric Acid; Indomethacin; Ligation; Male; Models, Biological; Omeprazole; Peptic Ulcer; Rats; Rats, Wistar | 1993 |
Pathways mediating pentagastrin-induced mucosal blood flow response in rat stomachs.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Drug Interactions; Gastric Acid; Gastric Mucosa; Glycine; Indomethacin; Male; Omeprazole; Pentagastrin; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Theophylline | 1996 |
Indomethacin damage to rat gastric mucosa is markedly dependent on luminal pH.
Topics: Acid-Base Equilibrium; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Indomethacin; Male; Mucous Membrane; Omeprazole; Rats; Rats, Inbred Strains; Stomach | 1996 |
Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Benzimidazoles; Indomethacin; Male; Omeprazole; Peroxidase; Rats; Rats, Inbred Strains; Stomach Ulcer; Sucralfate; Time Factors; Wound Healing | 1996 |
Effects of the novel histamine H2-receptor antagonist (+/-)-(E)-1-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-3-[2-[[[5- (methylamino)methyl-2-furyl]methyl]thio]ethyl]-2-(methylsulfonyl) guanidine on gastric secretion and gastroduodenal ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Epirizole; Gastric Acid; Gastric Mucosa; Guanidines; Histamine; Histamine H2 Antagonists; Indomethacin; Male; Omeprazole; Pepsin A; Peptic Ulcer; Ranitidine; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Stress, Psychological; Sulfones | 1996 |
Indomethacin-induced morphological changes in the rat gastric mucosa, with or without prior treatment with two proton pump inhibitors.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Drug Interactions; Gastric Mucosa; Indomethacin; Lansoprazole; Male; Microcirculation; Omeprazole; Proton Pump Inhibitors; Rats; Rats, Wistar; Stomach | 1995 |
Omeprazole prevents indomethacin-induced gastric ulcers in rabbits.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Indomethacin; Omeprazole; Proton Pump Inhibitors; Pyloric Antrum; Rabbits; Stomach Ulcer | 1996 |
The cytoprotective effect of leminoprazole on indomethacin-induced damage to rabbit gastric mucosal cells.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzimidazoles; Cells, Cultured; Cycloheximide; Dactinomycin; Dinoprostone; Gastric Mucosa; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Omeprazole; Rabbits | 1996 |
[Effects of lansoprazole on indomethacin-induced gastric bleeding and mucosal lesions in rats].
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Famotidine; Gastric Mucosa; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Indomethacin; Lansoprazole; Male; Omeprazole; Ranitidine; Rats; Rats, Sprague-Dawley | 1996 |
Leminoprazole protects cultured gastric mucosal cells against damage caused by ethanol, indometacin and taurocholate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzimidazoles; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Cholagogues and Choleretics; Cycloheximide; Dactinomycin; Dinoprostone; Ethanol; Gastric Mucosa; Indomethacin; Male; Omeprazole; Oxytocics; Protein Synthesis Inhibitors; Rabbits; Solvents; Taurocholic Acid | 1997 |
Nitric oxide, prostaglandin, and sensory neurons in gastric mucosal blood flow response during acid secretion in rats.
Topics: Animals; Capsaicin; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Omeprazole; Pentagastrin; Prostaglandins; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley | 1997 |
Induction of tumor necrosis factor-alpha and apoptosis in gastric mucosal injury by indomethacin: effect of omeprazole and ebrotidine.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Benzenesulfonates; Gastric Mucosa; Indomethacin; Omeprazole; Premedication; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Tumor Necrosis Factor-alpha | 1997 |
Increase in pH and prevention of gastropathy induced by nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Hydrogen-Ion Concentration; Indomethacin; Male; Omeprazole; Rats; Stomach Ulcer | 1997 |
Increased hepatocyte growth factor content in rat stomach during omeprazole treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Gastric Acid; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Gastrointestinal Agents; Gene Expression; Gene Expression Regulation; Genes; Hepatocyte Growth Factor; Hydrogen-Ion Concentration; Hydrolysis; Indomethacin; Male; Omeprazole; Pepsin A; Rats; Rats, Sprague-Dawley; Stomach; Stomach Diseases; Wound Healing | 1998 |
Biochemical and pharmacological characteristics of 3-butyryl-8-methoxy-4-[(2-thiophenyl)amino]quinoline, a new proton-pump inhibitor, in rabbit gastric microsomes and in rats.
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Indomethacin; Male; Microsomes; Omeprazole; Proton Pump Inhibitors; Quinolines; Rabbits; Rats; Rats, Sprague-Dawley; Solvents; Stomach Ulcer; Tocolytic Agents | 1998 |
Biochemical and pharmacological properties of a new proton pump inhibitor, 2-amino-4,5-dihydropyrido[1,2-a]thiazolo [5,4-g] benzimidazole (YJA20379-5).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzimidazoles; Epirizole; Ethanol; Female; Gastric Acid; Gastric Mucosa; Immersion; Indomethacin; Microsomes; Omeprazole; Peptic Ulcer; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Stress, Psychological; Swine; Thiazoles | 1998 |
New model of cytoprotection/adaptive cytoprotection in rats: endogenous small irritants, antiulcer agents and indomethacin.
Topics: Amino Acid Sequence; Anastomosis, Surgical; Animals; Anti-Ulcer Agents; Atropine; Cyclooxygenase Inhibitors; Cytoprotection; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Indomethacin; Irritants; Jejunum; Male; Molecular Sequence Data; Omeprazole; Peptic Ulcer; Peptide Fragments; Proteins; Ranitidine; Rats; Rats, Wistar; Stomach | 1999 |
Characterization of antisecretory and antiulcer activity of CR 2945, a new potent and selective gastrin/CCK(B) receptor antagonist.
Topics: Animals; Anti-Anxiety Agents; Anti-Ulcer Agents; Benzodiazepines; Benzodiazepinones; Calcium; Cats; Chronic Disease; Cysteamine; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; Gastric Fistula; Gastric Mucosa; Gastrins; Histamine H2 Antagonists; Indomethacin; Male; Omeprazole; Parietal Cells, Gastric; Pentagastrin; Perfusion; Phenylurea Compounds; Rabbits; Ranitidine; Rats; Receptors, Cholecystokinin; Stomach; Stomach Ulcer | 1999 |
Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress.
Topics: Acute Disease; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalase; Cimetidine; Diterpenes; Gastritis; Gastrointestinal Hemorrhage; Indomethacin; Leukocyte Count; Male; Neutrophils; Omeprazole; Perfusion; Quinolones; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Superoxide Dismutase | 1999 |
Role of endothelin-1 and constitutive nitric oxide synthase in gastric mucosal resistance to indomethacin injury: effect of antiulcer agents.
Topics: Animals; Anti-Ulcer Agents; Apoptosis; Endothelin-1; Gastric Mucosa; Indomethacin; Interleukin-4; Nitric Oxide Synthase; Omeprazole; Rats; Rats, Sprague-Dawley; Sucralfate | 1999 |
Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine.
Topics: Animals; Anti-Ulcer Agents; Benzenesulfonates; Disease Models, Animal; Gastric Juice; Histamine H2 Antagonists; Indomethacin; Male; Omeprazole; Ranitidine; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Thiazoles | 2000 |
Cytoprotective effect of rabeprazole against ethanol-induced gastric mucosal damage: possible involvement of nitric oxide.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzimidazoles; Enzyme Inhibitors; Gastric Mucosa; Indomethacin; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Omeprazole; Prostaglandins; Rabeprazole; Rats; Rats, Wistar; Stomach Ulcer | 2000 |
Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cold Temperature; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydroxyl Radical; Indomethacin; Lipid Peroxidation; Melatonin; Omeprazole; Peptic Ulcer; Ranitidine; Rats; Rats, Wistar; Stress, Physiological | 2000 |
Protective effects of prostaglandins in the isolated gastric mucosa of the eel, Anguilla anguilla.
Topics: Alkalies; Anguilla; Animals; Aspirin; Bicarbonates; Buffers; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; HEPES; Histamine; Indomethacin; Omeprazole; Sodium | 2000 |
Pharmacological properties of a newly synthesized H(+)/K(+) ATPase inhibitor, 1-(2-methyl-4-methoxyphenyl)-4-.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cysteamine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Indomethacin; Omeprazole; Perfusion; Proton Pump Inhibitors; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Sodium Hydroxide; Stomach; Stomach Ulcer; Time Factors | 2001 |
Haloperidol-stomach lesions attenuation by pentadecapeptide BPC 157, omeprazole, bromocriptine, but not atropine, lansoprazole, pantoprazole, ranitidine, cimetidine and misoprostol in mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Atropine; Benzimidazoles; Bromocriptine; Cimetidine; Disease Models, Animal; Domperidone; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Indomethacin; Lansoprazole; Male; Mice; Mice, Inbred Strains; Misoprostol; Omeprazole; Pantoprazole; Peptide Fragments; Proteins; Ranitidine; Stomach Diseases; Sulfoxides | 2001 |
Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Brazil; Cimetidine; Disease Models, Animal; Diterpenes; Euphorbiaceae; Female; Gastric Acid; Gastric Acidity Determination; Gastric Juice; Gastric Mucosa; Indomethacin; Lansoprazole; Male; Mice; Omeprazole; Peptic Ulcer; Plant Extracts; Rats; Rats, Wistar; Trees | 2001 |
Delayed healing of gastric ulcers in adjuvant arthritis rats: role of acid secretion and basic fibroblast growth factor.
Topics: Animals; Arthritis, Rheumatoid; Blotting, Western; Disease Models, Animal; Fibroblast Growth Factors; Gastric Acid; Gastric Mucosa; Indomethacin; Male; Omeprazole; Rats; Rats, Inbred Strains; Stomach Ulcer; Time Factors; Treatment Outcome | 2001 |
Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Ethanol; Gastric Mucosa; Indomethacin; Male; Misoprostol; Omeprazole; Ranitidine; Rats; Rats, Wistar; Shock, Hemorrhagic; Stomach Diseases | 2001 |
Inhibitor effect of omeprazole in isolated human myometrial smooth muscle.
Topics: Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Indomethacin; Isometric Contraction; Myometrium; NG-Nitroarginine Methyl Ester; Omeprazole; Pregnancy; Pregnancy Trimester, Third; Proton Pump Inhibitors | 2001 |
Involvement of heat shock proteins in the healing of acetic acid-induced gastric ulcers in rats.
Topics: Animals; Heat-Shock Proteins; HSC70 Heat-Shock Proteins; HSP47 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Indomethacin; Male; Omeprazole; Rats; Stomach Ulcer | 2001 |
Antiulcerogenic effect of Hippophae rhamnoides L.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Famotidine; Fruit; Indomethacin; Male; Misoprostol; Omeprazole; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Rosales; Stomach Ulcer; Stress, Physiological | 2001 |
A comparative study on the activity of lansoprazole, omeprazole and PD-136450 on acidified ethanol- and indomethacin-induced gastric lesions in the rat.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Central Nervous System Depressants; Enzyme Inhibitors; Ethanol; Female; Indoles; Indomethacin; Lansoprazole; Male; Omeprazole; Phenethylamines; Rats; Rats, Wistar; Stomach Ulcer | 2002 |
Influence of Helicobacter pylori infection on healing and relapse of acetic acid ulcers in Mongolian gerbils.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Indomethacin; Male; Omeprazole; Recurrence; Stomach Ulcer; Time Factors; Wound Healing | 2002 |
Anti-ulcerogenic and analgesic activities of the leaves of Wilbrandia ebracteata in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Brazil; Cimetidine; Cucurbitaceae; Ethanol; Female; Flavonoids; Gastric Mucosa; Indomethacin; Male; Mice; Morphine; Motor Activity; Omeprazole; Phytotherapy; Plant Extracts; Rats; Stomach Ulcer; Tail; Toxicity Tests, Acute | 2002 |
Omeprazole-induced relaxation in rat aorta is partly dependent on endothelium.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Omeprazole; Papaverine; Phenylephrine; Potassium Channel Blockers; Proton Pump Inhibitors; Rats; Tetraethylammonium; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
A new furoxan NO-donor rabeprazole derivative and related compounds.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Benzimidazoles; Drug Design; Helicobacter pylori; Indomethacin; Microbial Sensitivity Tests; Molecular Structure; Nitric Oxide Donors; Omeprazole; Oxadiazoles; Rabeprazole; Rats; Stomach Ulcer; Structure-Activity Relationship | 2003 |
Parietal cell density during gastric ulcer healing in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Count; Female; Helicobacter Infections; Indomethacin; Omeprazole; Parietal Cells, Gastric; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Thymidine; Wound Healing | 2004 |
Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Bethanechol; Cimetidine; Disease Models, Animal; Eriocaulaceae; Ethanol; Gastric Juice; Gastrointestinal Contents; Hydrogen-Ion Concentration; Indomethacin; Lansoprazole; Male; Mice; Mucus; Omeprazole; Phytotherapy; Plant Extracts; Prostaglandins; Rats; Rats, Wistar; Stomach Ulcer; Stress, Psychological | 2004 |
Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility.
Topics: Animals; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastrointestinal Motility; Indomethacin; Isoenzymes; Lactones; Male; Omeprazole; Peroxidase; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stomach; Stomach Ulcer; Sulfones | 2004 |
Monocyte chemotactic protein-1 regulates leukocyte recruitment during gastric ulcer recurrence induced by tumor necrosis factor-alpha.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antibodies; Antineoplastic Agents; Benzimidazoles; Cell Movement; Chemokine CCL2; Chemokine CCL3; Chemokine CCL4; Chemokine CXCL2; Chemokines; Chemokines, CXC; Gastric Acid; Gastric Mucosa; Indomethacin; Intercellular Adhesion Molecule-1; Intercellular Signaling Peptides and Proteins; Leukocytes; Macrophage Inflammatory Proteins; Male; Omeprazole; Rabeprazole; Rats; Rats, Wistar; Recurrence; RNA, Messenger; Specific Pathogen-Free Organisms; Stomach Ulcer; Tumor Necrosis Factor-alpha | 2004 |
The effects of apigenin-7-O-beta-D-glucuronopyranoside on reflux oesophagitis and gastritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apigenin; Clerodendrum; Dose-Response Relationship, Drug; Esophagitis, Peptic; Esophagus; Gastritis; Glutathione; Indomethacin; Lipid Peroxidation; Male; Omeprazole; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley | 2005 |
Mechanisms of protection by pantoprazole against NSAID-induced gastric mucosal damage.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Benzimidazoles; Diclofenac; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Glutathione; Indomethacin; Ligation; Lipoproteins, LDL; Male; Malondialdehyde; Omeprazole; Oxidation-Reduction; Pantoprazole; Peroxidase; Piroxicam; Proton Pump Inhibitors; Pylorus; Rats; Rats, Wistar; Sulfoxides | 2005 |
Combined use of omeprazole and a novel antioxidative cytoprotectant for the treatment of peptic ulcer. Facilitation of ulcer healing in experimental animals.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Artemisia; Central Nervous System Depressants; Cysteamine; Drug Therapy, Combination; Esophagitis, Peptic; Ethanol; Gastric Mucosa; Gastritis; Indomethacin; Male; Omeprazole; Peptic Ulcer; Plant Extracts; Rats; Rats, Sprague-Dawley | 2005 |
Participation of vanilloid/capsaicin receptors, calcitonin-gene-related peptide and substance P in gastric protection of omeprazole and omeprazole-like compounds.
Topics: Animals; Antioxidants; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Gastric Juice; Gastric Mucosa; Immunohistochemistry; Indomethacin; Injections, Subcutaneous; Omeprazole; Proteins; Pylorus; Rats; Structure-Activity Relationship; Substance P; TRPV Cation Channels | 2005 |
Lansoprazole, a proton pump inhibitor, reduces the severity of indomethacin-induced rat enteritis.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CXCL1; Chemokines, CXC; Enteritis; Indomethacin; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Intestine, Small; Lansoprazole; Male; Omeprazole; Peroxidase; Proton Pump Inhibitors; Proton Pumps; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2006 |
Is omeprazole or misoprostol superior for improving indomethacin-induced delayed maturation of granulation tissue in rat gastric ulcers?
Topics: Analysis of Variance; Animals; Collagen; Granulation Tissue; Hydroxyproline; Immunohistochemistry; In Situ Nick-End Labeling; Indomethacin; Male; Misoprostol; Omeprazole; Rats; Rats, Wistar; Stomach Ulcer; Wound Healing | 2006 |
The effect of luteolin-7-O-beta-D-glucuronopyranoside on gastritis and esophagitis in rats.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Esophagitis, Peptic; Gastric Acid; Gastric Acidity Determination; Gastritis; Glucosides; Indomethacin; Lipid Peroxidation; Luteolin; Male; Malondialdehyde; Omeprazole; Plant Leaves; Pylorus; Rats; Rats, Sprague-Dawley; Salix | 2006 |
Protective effects of proton pump inhibitors against indomethacin-induced lesions in the rat small intestine.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Translocation; Dose-Response Relationship, Drug; Humans; Indomethacin; Intestinal Mucosa; Intestine, Small; Intubation, Gastrointestinal; Jejunum; Lansoprazole; Male; Malondialdehyde; Neutrophil Infiltration; Omeprazole; Oxidative Stress; Peroxidase; Proton Pump Inhibitors; Rats; Rats, Wistar; Severity of Illness Index | 2007 |
Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions in rats.
Topics: Alkaloids; Ammonia; Animals; Armoracia; Aspirin; Benzodioxoles; Capsaicin; Dose-Response Relationship, Drug; Ethanol; Food Preservatives; Gastric Mucosa; Hydrochloric Acid; Indomethacin; Isothiocyanates; Male; NG-Nitroarginine Methyl Ester; Omeprazole; Piperidines; Polyunsaturated Alkamides; Prostaglandins; Rats; Rats, Sprague-Dawley; Ruthenium Red; Structure-Activity Relationship | 2007 |
Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Brazil; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gastric Acid; Gastric Acidity Determination; Hydrogen-Ion Concentration; Indomethacin; Male; Maytenus; Omeprazole; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Severity of Illness Index; Stomach Ulcer | 2007 |
Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Indomethacin; Lipid Peroxidation; Male; Mice; Mucins; Myristicaceae; Omeprazole; Phytotherapy; Plant Extracts; Protein Carbonylation; Stomach Ulcer; Sulfhydryl Compounds; Time Factors; Toxicity Tests, Acute | 2007 |
Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; ErbB Receptors; Fruit; Gastric Mucins; Gastric Mucosa; Glycogen; Indomethacin; Lipid Peroxidation; Male; Membrane Proteins; Mice; Myristicaceae; Omeprazole; Oxidative Stress; Periodic Acid-Schiff Reaction; Plant Extracts; Protein Carbonylation; Resorcinols; Stomach; Stomach Ulcer; Time Factors; Wound Healing | 2008 |
The role of sildenafil citrate in the protection of gastric mucosa from nonsteroidal anti-inflammatory drug-induced damage.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Female; Indomethacin; Nitric Oxide; Omeprazole; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Stomach Ulcer; Sulfones | 2007 |
The anti-secretory and anti-ulcer activities of esomeprazole in comparison with omeprazole in the stomach of rats and rabbits.
Topics: Aminopyrine; Animals; Anti-Ulcer Agents; Bucladesine; Carbon Isotopes; Dimaprit; Dinoprostone; Esomeprazole; Female; Gastric Acid; Gastric Mucosa; Histamine; Indomethacin; Inhibitory Concentration 50; Male; Omeprazole; Rabbits; Rats; Rats, Wistar; Stomach | 2008 |
Angiogenic and cell proliferating action of the natural diarylnonanoids, malabaricone B and malabaricone C during healing of indomethacin-induced gastric ulceration.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Proliferation; Dose-Response Relationship, Drug; Endostatins; Epidermal Growth Factor; Gastric Mucosa; Granulation Tissue; Indomethacin; Male; Mice; Misoprostol; Neovascularization, Physiologic; Omeprazole; Regional Blood Flow; Resorcinols; Stomach Ulcer; Vascular Endothelial Growth Factor A; von Willebrand Factor | 2008 |
Biochemical mechanism of healing activity of the natural phenolic, allylpyrocatechol against indomethacin-induced gastric ulceration in mice.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catechols; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Indomethacin; Male; Mice; Omeprazole; Oxidative Stress; Plant Extracts; Stomach Ulcer; Vascular Endothelial Growth Factor A; von Willebrand Factor; Wound Healing | 2008 |
Myristica malabarica heals stomach ulceration by increasing prostaglandin synthesis and angiogenesis.
Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Dinoprostone; Endostatins; Epidermal Growth Factor; Fruit; Gastric Mucosa; Indomethacin; Male; Mice; Myristicaceae; Neovascularization, Physiologic; Omeprazole; Oxytocics; Phytotherapy; Plant Extracts; Stomach Ulcer; Vascular Endothelial Growth Factor A; von Willebrand Factor | 2008 |
Antiulcerogenic and anti-inflammatory activities of the essential oil from Pterodon emarginatus seeds.
Topics: Administration, Oral; Alkyl and Aryl Transferases; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Brazil; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Fabaceae; Indomethacin; Interleukin-1alpha; Male; Medicine, Traditional; Mice; Monocyclic Sesquiterpenes; Nitric Oxide; Oils, Volatile; Omeprazole; Peptic Ulcer; Pleurisy; Polycyclic Sesquiterpenes; Ranitidine; Seeds; Sesquiterpenes; Tumor Necrosis Factor-alpha | 2009 |
Regulation of arginase/nitric oxide synthesis axis via cytokine balance contributes to the healing action of malabaricone B against indomethacin-induced gastric ulceration in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arginase; Cytokines; Indomethacin; Male; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Omeprazole; Peroxidase; Resorcinols; Stomach Ulcer | 2009 |
Effect of a gastrin-releasing peptide receptor antagonist and a proton pump inhibitor association in an animal model of gastritis.
Topics: Animals; Bombesin; Disease Models, Animal; Gastric Mucosa; Gastritis; Indomethacin; Lipid Peroxidation; Male; Mitochondria; Omeprazole; Peptide Fragments; Protein Carbonylation; Proton Pump Inhibitors; Rats; Rats, Wistar; Receptors, Bombesin; Superoxides; Thiobarbiturates | 2009 |
Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Central Nervous System Depressants; Cholinergic Agents; Chromatography, Thin Layer; Cimetidine; Cold Temperature; Ethanol; Fruit; Indomethacin; Male; Mice; Mice, Inbred BALB C; Omeprazole; Plant Extracts; Plant Leaves; Restraint, Physical; Stomach Ulcer; Stress, Psychological; Syzygium | 2009 |
Comparison of the protective effects of various antiulcer agents alone or in combination on indomethacin-induced gastric ulcers in rats.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Hematologic Tests; Indomethacin; Male; Misoprostol; Omeprazole; Ranitidine; Rats; Rats, Wistar; Stomach Ulcer | 2012 |
Gastrin-releasing peptide receptor antagonist or N-acetylcysteine combined with omeprazol protect against mitochondrial complex II inhibition in a rat model of gastritis.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bombesin; Drug Therapy, Combination; Electron Transport; Electron Transport Complex II; Electron Transport Complex III; Gastric Mucosa; Gastritis; Indomethacin; Male; Mitochondria; Omeprazole; Peptide Fragments; Proton Pump Inhibitors; Rats; Rats, Wistar; Receptors, Bombesin; Severity of Illness Index; Stomach; Stomach Ulcer | 2011 |
Black tea and theaflavins suppress various inflammatory modulators and i-NOS mediated nitric oxide synthesis during gastric ulcer healing.
Topics: Animals; Biflavonoids; Catechin; Cell Adhesion Molecules; Immunoblotting; Indomethacin; Mice; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Omeprazole; Peroxidase; Selectins; Stomach Ulcer; Tea; Wound Healing | 2011 |
Epigallocatechin gallate accelerates healing of indomethacin-induced stomach ulcers in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Catechin; Disease Models, Animal; Gastric Mucosa; Indomethacin; Lipid Peroxidation; Male; Mice; Omeprazole; Oxidative Stress; Stomach Ulcer; Tea | 2011 |
Comparative healing property of kombucha tea and black tea against indomethacin-induced gastric ulceration in mice: possible mechanism of action.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Fermentation; Free Radical Scavengers; Gastric Mucins; Gastric Mucosa; Indomethacin; Male; Mice; Omeprazole; Oxidative Stress; Plant Extracts; Stomach; Stomach Ulcer; Tea; Thiobarbituric Acid Reactive Substances; Wound Healing | 2010 |
Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity.
Topics: Animals; Bauhinia; Dose-Response Relationship, Drug; Gastrointestinal Agents; Indomethacin; Male; Methanol; Omeprazole; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Ulcer | 2012 |
In vitro and in vivo protection against indomethacin-induced small intestinal injury by proton pump inhibitors, acid pump antagonists, or indomethacin-phosphatidylcholine.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Survival; Cells, Cultured; Epithelial Cells; Gastrointestinal Hemorrhage; Indomethacin; Intestinal Mucosa; Intestine, Small; Lansoprazole; Male; Omeprazole; Phosphatidylcholines; Proton Pump Inhibitors; Pyrimidinones; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines | 2012 |
Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf.
Topics: Animals; Anti-Ulcer Agents; Bauhinia; Chloroform; Chromatography, High Pressure Liquid; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gastric Acid; Gastric Acidity Determination; Gastric Mucosa; Hydrogen-Ion Concentration; Indomethacin; Male; Mucus; Omeprazole; Plant Extracts; Plant Leaves; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Solvents; Stomach Ulcer | 2012 |
[Effect of mild irritants on gastric outputs of bicarbonates and pepsinogen depends on the rate of acid secretion].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Bicarbonates; Biological Transport; Electric Stimulation; Gastric Acid; Gastric Fistula; Gastric Mucosa; Hydrogen-Ion Concentration; Indomethacin; Irritants; Male; Omeprazole; Osmolar Concentration; Pepsinogens; Rats; Rats, Sprague-Dawley; Sodium Chloride; Vagus Nerve | 2012 |
Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Cytoprotection; Dinoprostone; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Female; Gastric Mucosa; Indomethacin; Leukotriene B4; Omeprazole; Proton Pump Inhibitors; Rats; Rats, Wistar; Stomach; Stomach Ulcer; Time Factors | 2012 |
Inhibition of TNF-α, and NF-κB and JNK pathways accounts for the prophylactic action of the natural phenolic, allylpyrocatechol against indomethacin gastropathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catechols; Disease Models, Animal; Indomethacin; Male; MAP Kinase Signaling System; Mice; Misoprostol; Omeprazole; Oxidative Stress; Piper betle; Stomach Ulcer; Tumor Necrosis Factor-alpha | 2013 |
Relaxant effect of proton pump inhibitors on in vitro myometrium from pregnant women.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Apamin; Calcium; Dinoprostone; Esomeprazole; Female; Humans; In Vitro Techniques; Indomethacin; Lansoprazole; Muscle Contraction; Myometrium; NG-Nitroarginine Methyl Ester; Omeprazole; Oxytocin; Pantoprazole; Peptides; Potassium Chloride; Pregnancy; Proton Pump Inhibitors; Rabeprazole; Tocolytic Agents | 2014 |
Effects of the administration of aqueous extract of de Sedum dendroideum on the histopathology of erosive induced gastritis by means of indomethacin in rats.
Topics: Acute Disease; Animals; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Gastric Mucosa; Gastritis; Indomethacin; Male; Omeprazole; Phytotherapy; Random Allocation; Rats; Rats, Wistar; Sedum | 2014 |
Anti-ulcerogenic mechanism of magnesium in indomethacin induced gastric ulcer in rats.
Topics: Animals; Anti-Ulcer Agents; Cytoprotection; Disease Models, Animal; Gastric Mucosa; Indomethacin; Magnesium Sulfate; Male; Omeprazole; Parietal Cells, Gastric; Proton Pump Inhibitors; Rats, Wistar; Stomach Ulcer; Time Factors | 2013 |
The molecular mechanism underlying the induction of hepatic MRP3 expression and function by omeprazole.
Topics: Biological Transport; Dactinomycin; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Indomethacin; Liver; Multidrug Resistance-Associated Proteins; Omeprazole; RNA, Small Interfering; Up-Regulation | 2015 |
Suppression of contractile activity in the small intestine by indomethacin and omeprazole.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Enteritis; Gastrointestinal Hemorrhage; Gastrointestinal Motility; Ileum; Indomethacin; Inflammation Mediators; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Omeprazole; Proton Pump Inhibitors; Rats, Sprague-Dawley | 2015 |
[ROLES OF CONSTITUTIVE SYNTHASES OF NITRIC OXIDE IN THE REGULATION OF GASTRIC BICARBONATE SECRETION INDUCED BY MILD IRRITATION OF THE MUCOSA].
Topics: Animals; Bicarbonates; Enzyme Inhibitors; Gastric Mucosa; Indazoles; Indomethacin; Irritants; Male; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitroarginine; Omeprazole; Rats, Sprague-Dawley | 2015 |
Nebivolol prevents indomethacin-induced gastric ulcer in rats.
Topics: Adrenergic beta-1 Receptor Agonists; Animals; Dinoprostone; Glutathione; Humans; Indomethacin; Male; Malondialdehyde; Nebivolol; Nitric Oxide; Omeprazole; Rats; Rats, Wistar; Stomach Ulcer; Tumor Necrosis Factor-alpha | 2016 |
Interaction of Constitutive Nitric Oxide Synthases with Cyclooxygenases in Regulation of Bicarbonate Secretion in the Gastric Mucosa.
Topics: Animals; Bicarbonates; Gastric Mucosa; Indazoles; Indomethacin; Male; Nitric Oxide Synthase; Omeprazole; Prostaglandin-Endoperoxide Synthases; Protein Binding; Rats; Rats, Sprague-Dawley; Sodium Chloride | 2017 |
Effect of Hydrotalcite on Indometacin-Induced Gastric Injury in Rats.
Topics: Aluminum Hydroxide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Epidermal Growth Factor; Female; Gastric Mucosa; Indomethacin; Magnesium Hydroxide; Male; Membrane Proteins; Omeprazole; Ranitidine; Rats; Rats, Wistar; Stomach; Stomach Ulcer | 2019 |
[Therapeutic effect of total triterpenoids of Chaenomeles speciosa combined with omeprazole on gastric ulcer induced by indomethacin in rats].
Topics: Animals; Cytokines; Gastric Mucosa; Indomethacin; Omeprazole; Phytochemicals; Random Allocation; Rats; Rosaceae; Stomach Ulcer; Triterpenes; Tumor Necrosis Factor-alpha | 2019 |
Proton Pump Inhibitors Prevent Gastric Antral Ulcers Induced by NSAIDs via Activation of Capsaicin-Sensitive Afferent Nerves in Mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Disease Models, Animal; Gastric Emptying; Gastric Juice; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Lansoprazole; Male; Mice; Neurons, Afferent; Omeprazole; Proton Pump Inhibitors; Pyloric Antrum; Stomach Ulcer | 2020 |
Synergistic protective effects between docosahexaenoic acid and omeprazole on the gastrointestinal tract in the indomethacin-induced injury model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Drug Synergism; Female; Gastrointestinal Tract; Indomethacin; Omeprazole; Rats; Rats, Wistar | 2021 |
The effect of metformin on indomethacin-induced gastric ulcer: Involvement of nitric oxide/Rho kinase pathway.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Gastric Mucosa; Indomethacin; Male; Metformin; NF-kappa B; Nitric Oxide; Omeprazole; Proton Pump Inhibitors; Rats, Wistar; rho-Associated Kinases; Signal Transduction; Stomach Ulcer; Tumor Necrosis Factor-alpha; Wound Healing | 2021 |
Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis of Early COVID-19 and Treated at Home Within 3 Days or After 3 Days of Symptom Onset with Prescribed and Non-Prescribed Treatments Between November 2
Topics: Aged; Aged, 80 and over; Aspirin; Betamethasone; Cohort Studies; COVID-19; COVID-19 Drug Treatment; Dietary Supplements; Early Diagnosis; Female; Flavonoids; Follow-Up Studies; Heparin, Low-Molecular-Weight; Hospitalization; Humans; Indomethacin; Italy; Male; Middle Aged; Omeprazole; Patient Acuity; Retrospective Studies; Risk Assessment; SARS-CoV-2; Time; Time-to-Treatment; Treatment Outcome | 2021 |
The influence of different proton pump inhibitors and potassium-competitive acid blockers on indomethacin-induced small intestinal injury.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; DNA, Ribosomal; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lipopolysaccharides; Mice; Omeprazole; Potassium; Proton Pump Inhibitors; Pyrroles; Rabeprazole; Sulfonamides | 2022 |