omeprazole and fluorouracil

omeprazole has been researched along with fluorouracil in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.00)18.7374
1990's2 (10.00)18.2507
2000's10 (50.00)29.6817
2010's6 (30.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Becker, HD1
Bloom, SR; Hammond, PJ1
Abbasciano, V; Nielsen, I; Sartori, S; Tassinari, D; Trevisani, L1
Abbasciano, V; Nielsen, I; Panzini, I; Sartori, S; Tassinari, D; Trevisani, L1
Arancia, G; Belardelli, F; De Milito, A; Fais, S; Federici, C; Iessi, E; Logozzi, M; Lozupone, F; Luciani, F; Lugini, L; Marra, M; Molinari, A; Montinaro, A; Parmiani, G; Rivoltini, L; Spada, M1
Dimaline, R; Dockray, GJ; Duckworth, CA; Ottewell, PD; Pritchard, DM; Varro, A; Wang, TC; Watson, AJ1
Amaddeo, P; Barbaglio, A; Faldi, F; Fontana, S; Ghilardi, R; Pericotti, S1
Goso, Y; Ichikawa, T; Ikezawa, T; Ishihara, K; Iwai, T; Nakano, M; Saegusa, Y; Saigenji, K; Shikama, N1
Ellinger, S; Henne-Bruns, D; Klapperstueck, T; Knippschild, U; Kreyes, A; Landfester, K; Udelnow, A; Walther, P; Wohlrab, J; Würl, P1

Reviews

2 review(s) available for omeprazole and fluorouracil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Zollinger-Ellison syndrome].
    Wiener klinische Wochenschrift, 1984, Feb-17, Volume: 96, Issue:4

    Topics: Benzimidazoles; Calcium; Cimetidine; Diarrhea; Duodenal Ulcer; Female; Fluorouracil; Gastrectomy; Gastric Acid; Gastrins; Glucagon; Humans; Male; Middle Aged; Omeprazole; Pancreatic Neoplasms; Prognosis; Ranitidine; Secretin; Streptozocin; Zollinger-Ellison Syndrome

1984

Trials

2 trial(s) available for omeprazole and fluorouracil

ArticleYear
Misoprostol and omeprazole in the prevention of chemotherapy-induced acute gastroduodenal mucosal injury. A randomized, placebo-controlled pilot study.
    Cancer, 1996, Oct-01, Volume: 78, Issue:7

    Topics: Adult; Aged; Anti-Ulcer Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Fluorouracil; Gastric Acid; Gastric Mucosa; Humans; Male; Methotrexate; Middle Aged; Misoprostol; Omeprazole; Peptic Ulcer; Pilot Projects

1996
Randomized trial of omeprazole or ranitidine versus placebo in the prevention of chemotherapy-induced gastroduodenal injury.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:3

    Topics: Adult; Aged; Anti-Ulcer Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Duodenal Ulcer; Female; Fluorouracil; Gastric Mucosa; Histamine H2 Antagonists; Humans; Intestinal Mucosa; Male; Methotrexate; Middle Aged; Omeprazole; Ranitidine; Stomach Ulcer

2000

Other Studies

16 other study(ies) available for omeprazole and fluorouracil

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Gut neuroendocrine tumors.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dacarbazine; Diazoxide; Etoposide; Fluorouracil; Gastrointestinal Neoplasms; Humans; Interferon-alpha; Neuroendocrine Tumors; Octreotide; Omeprazole; Pancreatic Neoplasms; Streptozocin

1994
Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs.
    Journal of the National Cancer Institute, 2004, Nov-17, Volume: 96, Issue:22

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenocarcinoma; Animals; Antineoplastic Agents; Benzimidazoles; Blotting, Western; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Electrophoresis, Polyacrylamide Gel; Esomeprazole; Fluorouracil; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Inhibitory Concentration 50; Lymphoma; Melanoma; Mice; Mice, SCID; Microscopy, Confocal; Omeprazole; Pantoprazole; Proton Pump Inhibitors; Sulfoxides; Transplantation, Heterologous; Vinblastine

2004
Gastrin increases murine intestinal crypt regeneration following injury.
    Gastroenterology, 2006, Volume: 130, Issue:4

    Topics: Animals; Benzodiazepinones; Cell Line; Cell Proliferation; Colitis; Dextran Sulfate; Enteritis; Enzyme Inhibitors; Fluorouracil; Gamma Rays; Gastrins; Growth Substances; Intestinal Mucosa; Mice; Mice, Inbred Strains; Mice, Transgenic; Omeprazole; Phenylurea Compounds; Proton Pump Inhibitors; Receptor, Cholecystokinin B; Regeneration; Wounds and Injuries

2006
Male breast cancer with mandibular metastasis. A case report.
    Minerva stomatologica, 2007, Volume: 56, Issue:4

    Topics: Aged; Androstadienes; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Bone Neoplasms; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Cortisone; Cyclophosphamide; Diphosphonates; Docetaxel; Fatal Outcome; Fluorouracil; Furosemide; Humans; Imidazoles; Liver Neoplasms; Male; Mandibular Neoplasms; Mastectomy, Modified Radical; Methotrexate; Omeprazole; Osteolysis; Phenobarbital; Taxoids; Toremifene; Vinblastine; Vinorelbine; Zoledronic Acid

2007
Effects of acid antisecretory drugs on mucus barrier of the rat against 5-fluorouracil-induced gastrointestinal mucositis.
    Scandinavian journal of gastroenterology, 2008, Volume: 43, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetamides; Animals; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Fluorouracil; Gastric Mucosa; Gastrointestinal Diseases; Intestinal Mucosa; Lansoprazole; Male; Mucins; Mucositis; Omeprazole; Piperidines; Pyridines; Rats; Rats, Wistar

2008
Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells.
    PloS one, 2011, Volume: 6, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Autophagy; Blotting, Western; Cathepsin D; Cell Line, Tumor; Cell Proliferation; Coatomer Protein; Deoxycytidine; Fluorouracil; Gemcitabine; Golgi Apparatus; Humans; Lysosomal Membrane Proteins; Lysosomes; Magnetic Resonance Spectroscopy; Male; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Omeprazole; Pancreatic Neoplasms; Ultracentrifugation

2011