omeprazole has been researched along with dextromethorphan in 60 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 1 (1.67) | 18.2507 |
2000's | 11 (18.33) | 29.6817 |
2010's | 40 (66.67) | 24.3611 |
2020's | 8 (13.33) | 2.80 |
Authors | Studies |
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Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Isoherranen, N; Lutz, JD | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
Dalvie, D; Loi, CM; Smith, DA | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL | 1 |
Chen, P; Flockhart, DA; Ko, JW; Sukhova, N; Thacker, D | 1 |
Bertino, JS; Bleakley, JF; Gaedigk, A; Gotschall, R; Kearns, GL; Kim, JS; Leeder, JS; Nafziger, AN; Streetman, DS | 1 |
Brakenhoff, JP; de Leij, LF; de Zeeuw, RA; Gerrits, MG; Jonkman, JH; Oosterhuis, B; Tamminga, WJ; Wemer, J | 1 |
Bell, AR; Crewe, HK; Graham, MJ; Lennard, MS; Moorcraft, CL; Walker, L; Whittaker, EF | 1 |
Bertino, JS; Chainuvati, S; Gaedigk, A; Kashuba, AD; Kearns, GL; Leeder, JS; Nafziger, AN; Rowland, E; Sellers, E; Zhang, Y | 1 |
Cherkaoui, S; Daali, Y; Dayer, P; Jerdi, MC; Oestreicher, MK | 1 |
Bertino, JS; Gaedigk, A; Kashuba, AD; Kearns, G; Leeder, JS; Nafziger, AN; Rowland, E; Sellers, E; Shelepova, T; Victory, J; Zhang, Y | 1 |
Adkison, KK; Berrey, MM; Bertino, JS; Borland, J; Fang, L; Johnson, BM; Lou, Y; Nafziger, AN; Piscitelli, SC; Song, IH | 1 |
Cha, IJ; Liu, KH; Ryu, JY; Shin, JG; Shon, JH; Song, IS; Sunwoo, YE | 1 |
Chem, MC; Chetty, M; Ghassabian, S; Glen, J; McLachlan, AJ; Murray, M; Rahme, J; Ramzan, I; Stankovic, Z; Tattam, BN | 1 |
Cho, JY; Hong, JH; Jang, IJ; Kim, BH; Kim, J; Kim, KP; Lim, KS; Shin, SG; Yi, S; Yu, KS | 1 |
Bertelsen, K; Guo, P; Han, F; Huang, MQ; Lin, ZJ; Weng, N; Zhang, W; Zhao, H | 1 |
Flaherty, KT; Frye, RF; Lathia, C; O'Dwyer, PJ; Redlinger, M; Rosen, M; Schuchter, L | 1 |
Chen, Y; Guo, Y; Klaassen, CD; Tan, ZR; Zhou, HH | 1 |
Auwärter, V; Dresen, S; Lutz-Bonengel, S; Naue, J; Wohlfarth, A | 1 |
Chen, Y; Kang, Z; Ouyang, DS; Tan, ZR; Yan, J; Yang, GP; Zhou, G | 1 |
Takayanagi, R; Teramoto, S; Uotsu, N; Yamada, M; Yamada, Y; Yamasaki, I | 1 |
Chalasani, N; Hall, SD; Jones, DR; Mattar, S; Tandra, S; Vuppalanchi, R | 1 |
Aharchi, F; De Smedt, G; Hoetelmans, RM; Kakuda, TN; Leopold, L; Onkelinx, J; Peeters, M; Stevens, T; Van Solingen-Ristea, RM | 1 |
Kuhlmann, J; Kuhlmann, JB; Wensing, G | 1 |
Namiki, N; Tanaka, S; Uchida, S | 1 |
Bosilkovska, M; Daali, Y; Déglon, J; Desmeules, J; Samer, C; Staub, C; Walder, B | 1 |
Davis, C; Foti, RS; Isoherranen, N; Kunze, KL; Lutz, JD; Sager, JE | 1 |
de Andrés, F; Llerena, A; Sosa-Macías, M | 1 |
Bosilkovska, M; Daali, Y; Dayer, P; Déglon, J; Desmeules, JA; Rebsamen, M; Samer, CF; Staub, C; Walder, B | 1 |
Doogue, MP; Miners, JO; Polasek, TM; Rowland, A; Snyder, BD | 1 |
Corcoran, M; Ermer, J; Martin, P | 1 |
Murayama, N; Shida, S; Shimizu, M; Uno, Y; Utoh, M; Yamazaki, H | 1 |
Dai, GL; Ju, WZ; Rong, N; Sun, BT; Tan, HS; Zang, YX; Zhao, WZ | 1 |
Bénech, H; Lenuzza, N; Nguyen, TT; Pruvost, A | 1 |
Bovera, M; de Andrés, F; Fariñas, H; LLerena, A; Terán, E; Terán, S | 1 |
Hellum, B; Nilsen, OG; Spigset, O; Thu, OK | 1 |
Lutz, WK; Schönfelder, G; Steinfath, M; Vogl, S | 1 |
Bosilkovska, M; Daali, Y; Déglon, J; Desmeules, J; Samer, C; Thomas, A; Walder, B | 1 |
Armani, S; Chun, DY; Darstein, C; Einolf, HJ; Gu, H; Kulkarni, S; Sauter, N; Ting, L; Tripathi, AP; Wang, L; Zhu, B | 1 |
Edwards, JE; Eliot, L; Karan, S; MacConell, L; Parkinson, A | 1 |
Mangoni, AA; Rowland, A; Sorich, MJ; van Dyk, M; Warncken, D | 1 |
Bailey-Smith, C; Bodrug, I; Cheng, A; Glasgow, XS; Hussain, A; Iwamoto, M; Khalilieh, S; Levine, V; Martinho, M; Mekokishvili, L; Montgomery, D; Shaw, PM | 1 |
Dai, GL; He, SF; Hu, HB; Ju, WZ; Zhang, Q; Zhu, LJ | 1 |
Choi, MK; Choi, WG; Han, YH; Heo, JK; Jo, J; Kang, WY; Lee, HS; Lee, HW; Lee, S; Liu, KH; Ohk, B; Seong, SJ; Song, IS; Yoon, YR | 1 |
Kansra, V; Lu, S; Powers, D; Wang, J; Wang, X; Zhang, ZY | 1 |
Collins, C; Ernault, E; Fuhr, R; Gangaram-Panday, S; Passier, P; Treijtel, N; van Bruijnsvoort, M | 1 |
Ducray, PS; Endo-Tsukude, C; Gardner, I; Gill, KL; Hatley, OJ; Machavaram, KK; Parrott, N; Terao, K | 1 |
Chiasson, JL; Grangeon, A; Gravel, S; Michaud, V; Turgeon, J | 1 |
Aboagye, EO; Clarke, S; Edwards, RJ; Lee, P; Liddle, C; Lozan-Kuehne, JP; Maslen, L; Ramaswami, R; Sharma, R; Trousil, S | 1 |
Enejosa, JV; Feng, T; Fisniku, O; Mohamed, MF; Othman, AA | 1 |
Eagles, SK; Gross, AS; McLachlan, AJ; Wang, X | 1 |
Hakamata, A; Inui, N; Kamiya, C; Katayama, N; Kawakami, J; Miura, M; Namiki, N; Odagiri, K; Tanaka, S; Uchida, S; Watanabe, H | 1 |
Brantley, SJ; Dai, X; Goulet, MT; Hard, ML; Hitron, M; Karol, MD; McLaughlin, CF | 1 |
Ang, DSW; Ang, TL; Benech, H; Koo, SH; Lee, EJD; Pruvost, A; Soon, GH | 1 |
Newman, EM; Rowland, A | 1 |
Aarnoutse, RE; Boeree, MJ; Coenen, MJH; Colbers, A; Dawson, R; Diacon, AH; Fuhr, U; Jager, Vd; Narunsky, K; Padayachee, SD; Phillips, PPJ; Stemkens, R; Svensson, EM; Te Brake, LHM; van Beek, SW | 1 |
2 review(s) available for omeprazole and dextromethorphan
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
A Physiologically Based Pharmacokinetic Model to Predict the Impact of Metabolic Changes Associated with Metabolic Associated Fatty Liver Disease on Drug Exposure.
Topics: Animals; Caffeine; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dextromethorphan; Metoprolol; Midazolam; Non-alcoholic Fatty Liver Disease; Omeprazole; Rosiglitazone; Warfarin | 2022 |
25 trial(s) available for omeprazole and dextromethorphan
Article | Year |
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Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
Topics: Acetyltransferases; Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Genotype; Humans; Midazolam; Middle Aged; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Phosphodiesterase Inhibitors; Reproducibility of Results; Vitamins; Warfarin; Xanthine Oxidase | 2003 |
Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
Topics: Adult; Arylamine N-Acetyltransferase; Caffeine; Contraceptives, Oral; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Ethinyl Estradiol; Female; Genotype; Humans; Midazolam; Norgestrel; Omeprazole; Therapeutic Equivalency; Vitamin K; Warfarin; Xanthine Oxidase | 2005 |
Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail.
Topics: Adult; Anti-HIV Agents; Aryl Hydrocarbon Hydroxylases; Benzoates; Caffeine; CCR5 Receptor Antagonists; Dextromethorphan; Diketopiperazines; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged; Omeprazole; Piperazines; Spiro Compounds; Warfarin | 2006 |
Development of the "Inje cocktail" for high-throughput evaluation of five human cytochrome P450 isoforms in vivo.
Topics: Administration, Oral; Adult; Aryl Hydrocarbon Hydroxylases; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Genotype; Humans; Isoenzymes; Linear Models; Losartan; Male; Midazolam; Mixed Function Oxygenases; Omeprazole; Phenotype; Polymerase Chain Reaction; Reference Values; Time Factors | 2007 |
Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: a phase I/II pharmacokinetic interaction study.
Topics: Antineoplastic Agents; Area Under Curve; Benzenesulfonates; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Isoenzymes; Melanoma; Midazolam; Niacinamide; Omeprazole; Phenylurea Compounds; Pyridines; Sorafenib | 2011 |
Repeated administration of berberine inhibits cytochromes P450 in humans.
Topics: Adult; Berberine; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Drug Interactions; Drugs, Chinese Herbal; Enzyme Inhibitors; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult | 2012 |
Effect of a traditional Chinese medicine Liu Wei Di Huang Wan on the activities of CYP2C19, CYP2D6 and CYP3A4 in healthy volunteers.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; China; Cross-Over Studies; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Dextromethorphan; Drugs, Chinese Herbal; Genotype; Herb-Drug Interactions; Humans; Male; Midazolam; Omeprazole; Placebos | 2012 |
Pharmacokinetic and pharmacodynamic alterations in the Roux-en-Y gastric bypass recipients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Biotransformation; Caffeine; Case-Control Studies; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Dextromethorphan; Diuretics; Excitatory Amino Acid Antagonists; Female; Furosemide; GABA Modulators; Gastric Bypass; Humans; Hypoglycemic Agents; Male; Midazolam; Middle Aged; Omeprazole; Pharmacokinetics; Tandem Mass Spectrometry; Tolbutamide; Young Adult | 2013 |
The effect of single- and multiple-dose etravirine on a drug cocktail of representative cytochrome P450 probes and digoxin in healthy subjects.
Topics: Adolescent; Adult; Anti-HIV Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Nitriles; Omeprazole; Pyridazines; Pyrimidines; Reverse Transcriptase Inhibitors; Theophylline; Warfarin; Young Adult | 2014 |
Correlation of genotype, phenotype, and mRNA expression of CYP2D6 and CYP2C19 in peripheral blood leukocytes (PBLs).
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Female; Genotype; Humans; Leukocytes; Male; Middle Aged; Omeprazole; Phenotype; RNA, Messenger; Young Adult | 2014 |
Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions.
Topics: Adult; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Felodipine; Female; Genotype; Humans; Losartan; Male; Midazolam; Omeprazole; Young Adult | 2014 |
Lisdexamfetamine Dimesylate Effects on the Pharmacokinetics of Cytochrome P450 Substrates in Healthy Adults in an Open-Label, Randomized, Crossover Study.
Topics: Adult; Area Under Curve; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Lisdexamfetamine Dimesylate; Male; Midazolam; Omeprazole | 2015 |
A limited sampling strategy based on maximum a posteriori Bayesian estimation for a five-probe phenotyping cocktail.
Topics: Bayes Theorem; Caffeine; Computer Simulation; Dextromethorphan; Drug Interactions; Humans; Midazolam; Models, Biological; Omeprazole; Phenotype; Pilot Projects; Tolbutamide | 2016 |
Effect of commercial Rhodiola rosea on CYP enzyme activity in humans.
Topics: Adult; Caffeine; Cross-Over Studies; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Losartan; Male; Midazolam; Omeprazole; Plant Extracts; Rhodiola; Young Adult | 2016 |
Evaluation of Mutual Drug-Drug Interaction within Geneva Cocktail for Cytochrome P450 Phenotyping using Innovative Dried Blood Sampling Method.
Topics: Adolescent; Adult; Bupropion; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Dose-Response Relationship, Drug; Dried Blood Spot Testing; Drug Interactions; Female; Flurbiprofen; Genotyping Techniques; Humans; Male; Midazolam; Omeprazole; Phenotype; Terfenadine; Young Adult | 2016 |
Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy Adults.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Imidazoles; Male; Midazolam; Middle Aged; Omeprazole; Pituitary ACTH Hypersecretion; Pyridines | 2017 |
Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol.
Topics: Adult; Area Under Curve; Caffeine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Losartan; Male; Midazolam; Modafinil; Omeprazole; Phenotype; Time Factors; Young Adult | 2018 |
Effect of tildrakizumab (MK-3222), a high affinity, selective anti-IL23p19 monoclonal antibody, on cytochrome P450 metabolism in subjects with moderate to severe psoriasis.
Topics: Administration, Oral; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Humans; Injections, Subcutaneous; Interleukin-23 Subunit p19; Male; Midazolam; Middle Aged; Omeprazole; Psoriasis; Severity of Illness Index; Treatment Outcome; Warfarin; Young Adult | 2018 |
Effects of rolapitant administered orally on the pharmacokinetics of dextromethorphan (CYP2D6), tolbutamide (CYP2C9), omeprazole (CYP2C19), efavirenz (CYP2B6), and repaglinide (CYP2C8) in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Alkynes; Antiemetics; Benzoxazines; Carbamates; Cyclopropanes; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Dextromethorphan; Drug Combinations; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Middle Aged; Molecular Probes; Neurokinin-1 Receptor Antagonists; Omeprazole; Piperidines; Spiro Compounds; Tolbutamide; Young Adult | 2019 |
A Cocktail Interaction Study Evaluating the Drug-Drug Interaction Potential of the Perpetrator Drug ASP8477 at Multiple Ascending Dose Levels.
Topics: Administration, Oral; Adult; Area Under Curve; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Dextromethorphan; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Losartan; Male; Midazolam; Middle Aged; Omeprazole; Piperidines; Pyridines; Young Adult | 2019 |
Altered cytochrome 2E1 and 3A P450-dependent drug metabolism in advanced ovarian cancer correlates to tumour-associated inflammation.
Topics: Adult; Aged; Aged, 80 and over; C-Reactive Protein; Caffeine; Chlorzoxazone; Cytochrome P-450 Enzyme System; Cytokines; Dextromethorphan; Female; Humans; Inflammation; Middle Aged; Omeprazole; Ovarian Neoplasms | 2019 |
Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail.
Topics: Adult; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Female; Genotype; Healthy Volunteers; Heterocyclic Compounds, 3-Ring; Humans; Janus Kinase Inhibitors; Male; Midazolam; Middle Aged; Omeprazole; Phenotype; Vitamin K; Warfarin | 2020 |
Prediction of the Area under the Curve Using Limited-Point Blood Sampling in a Cocktail Study to Assess Multiple CYP Activities.
Topics: Administration, Oral; Adult; Area Under Curve; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Losartan; Male; Midazolam; Models, Biological; Omeprazole; Young Adult | 2021 |
Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers.
Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzofurans; Bupropion; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Female; Flurbiprofen; Gene Expression Regulation; Half-Life; Healthy Volunteers; Humans; Male; Midazolam; Naphthoquinones; Neoplasm Proteins; Omeprazole; Rosuvastatin Calcium; Young Adult | 2021 |
Evaluation of a six-probe cocktail (caffeine, tolbutamide, omeprazole, dextromethorphan, midazolam, and digoxin) approach to estimate hepatic drug detoxification capability and dosage requirements after a single oral dosing in healthy Chinese volunteers.
Topics: Caffeine; China; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Healthy Volunteers; Humans; Midazolam; Omeprazole; Tolbutamide | 2022 |
33 other study(ies) available for omeprazole and dextromethorphan
Article | Year |
---|---|
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole.
Topics: Dextromethorphan; Humans; Microsomes, Liver; Omeprazole; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Development; Enzyme Inhibitors; Freund's Adjuvant; Humans; Lipopolysaccharides; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Structure-Activity Relationship | 2021 |
Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Chlorzoxazone; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Lansoprazole; Mephenytoin; Microsomes, Liver; Omeprazole; Phenacetin; Tolbutamide | 1997 |
Combined phenotypic assessment of CYP1A2, CYP2C19, CYP2D6, CYP3A, N-acetyltransferase-2, and xanthine oxidase with the "Cooperstown cocktail".
Topics: Administration, Oral; Adult; Anti-Anxiety Agents; Anti-Ulcer Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Arylamine N-Acetyltransferase; Caffeine; Central Nervous System Stimulants; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Combinations; Drug Interactions; Female; Genotype; Humans; Hypnotics and Sedatives; Male; Midazolam; Middle Aged; Mixed Function Oxygenases; Omeprazole; Oxidoreductases, N-Demethylating; Phenotype; Polymerase Chain Reaction; Xanthine Oxidase | 2000 |
An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19.
Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Genotype; Humans; Male; Metoprolol; Mixed Function Oxygenases; Omeprazole; Phenotype; Polymerase Chain Reaction | 2001 |
mRNA and protein expression of dog liver cytochromes P450 in relation to the metabolism of human CYP2C substrates.
Topics: Algorithms; Animals; Cytochrome P-450 Enzyme System; Dextromethorphan; Dogs; Female; Humans; Isoenzymes; Kinetics; Liver; Male; Mephenytoin; Microsomes, Liver; Omeprazole; Protein Biosynthesis; RNA, Messenger; Warfarin | 2003 |
A simplified analytical method for a phenotyping cocktail of major CYP450 biotransformation routes.
Topics: Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Flurbiprofen; Humans; Isoenzymes; Midazolam; Omeprazole; Phenotype; Reproducibility of Results; Sensitivity and Specificity | 2004 |
A high-throughput assay using liquid chromatography-tandem mass spectrometry for simultaneous in vivo phenotyping of 5 major cytochrome p450 enzymes in patients.
Topics: Biotransformation; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Losartan; Midazolam; Omeprazole; Phenotype; Tandem Mass Spectrometry | 2009 |
Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix extracts on cytochrome P450 activities in healthy volunteers.
Topics: Adult; Angelica; Aryl Hydrocarbon Hydroxylases; Caffeine; Chlorzoxazone; Chromatography, High Pressure Liquid; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Dextromethorphan; Drugs, Chinese Herbal; Herb-Drug Interactions; Humans; Losartan; Male; Midazolam; Omeprazole; Phytotherapy; Republic of Korea; Scutellaria baicalensis; Tandem Mass Spectrometry; Young Adult | 2009 |
Simultaneous determination of tolbutamide, omeprazole, midazolam and dextromethorphan in human plasma by LC-MS/MS--a high throughput approach to evaluate drug-drug interactions.
Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Discovery; Drug Interactions; Drug Stability; High-Throughput Screening Assays; Humans; Midazolam; Omeprazole; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Temperature; Tolbutamide | 2010 |
Cocktail approach for in vivo phenotyping of 5 major CYP450 isoenzymes: development of an effective sampling, extraction, and analytical procedure and pilot study with comparative genotyping.
Topics: Adult; Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Genotype; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Phenotype; Pilot Projects; Tandem Mass Spectrometry; Tolbutamide; Young Adult | 2012 |
Inhibitory effects of kale ingestion on metabolism by cytochrome P450 enzymes in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Brassica; Caffeine; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochromes; Dextromethorphan; Enzyme Inhibitors; Herb-Drug Interactions; Liver; Metabolic Clearance Rate; Midazolam; Omeprazole; Rats; RNA, Messenger; Tolbutamide | 2012 |
Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats.
Topics: Animals; Caffeine; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dextromethorphan; Drug Interactions; Fluconazole; Fluvoxamine; Ketoconazole; Losartan; Male; Midazolam; Omeprazole; Rats, Sprague-Dawley | 2014 |
Simultaneous LC-MS/MS quantification of P-glycoprotein and cytochrome P450 probe substrates and their metabolites in DBS and plasma.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Calibration; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Flurbiprofen; Half-Life; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine | 2014 |
Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4.
Topics: Adult; Antidepressive Agents, Second-Generation; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Computer Simulation; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dextromethorphan; Drug Interactions; Female; Fluoxetine; Half-Life; Hepatocytes; Humans; Lovastatin; Male; Midazolam; Models, Statistical; Omeprazole; Stereoisomerism | 2014 |
A rapid and simple LC-MS/MS method for the simultaneous evaluation of CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 hydroxylation capacity.
Topics: Caffeine; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Hydroxylation; Losartan; Omeprazole; Tandem Mass Spectrometry | 2014 |
Geneva cocktail for cytochrome p450 and P-glycoprotein activity assessment using dried blood spots.
Topics: Administration, Oral; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bupropion; Caffeine; Capsules; Carbonated Beverages; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Coffee; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Dried Blood Spot Testing; Enzyme Inhibitors; Feasibility Studies; Flurbiprofen; Humans; Isoenzymes; Male; Midazolam; Omeprazole; Pharmaceutical Preparations; Phenotype; Pilot Projects; Predictive Value of Tests; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine; Young Adult | 2014 |
Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.
Topics: Administration, Intravenous; Administration, Oral; Animals; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Macaca fascicularis; Microsomes, Liver; Midazolam; Models, Biological; Omeprazole; Pharmacokinetics; Warfarin | 2015 |
[Study of change in activity of hepatic drug metabolism enzymes in rat model of chronic unpredictable mild stress].
Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Liver; Midazolam; Omeprazole; Rats; Stress, Physiological; Tandem Mass Spectrometry; Theophylline; Tolbutamide | 2015 |
Multiplex Phenotyping for Systems Medicine: A One-Point Optimized Practical Sampling Strategy for Simultaneous Estimation of CYP1A2, CYP2C9, CYP2C19, and CYP2D6 Activities Using a Cocktail Approach.
Topics: Area Under Curve; Caffeine; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Inactivation, Metabolic; Losartan; Omeprazole; Phenotype; Young Adult | 2016 |
Effect of Omeprazole and Dextromethorphan on the Urinary Metabolic Ratio of Flurbiprofen.
Topics: Adult; Cytochrome P450 Family 2; Dextromethorphan; Drug Interactions; Female; Flurbiprofen; Germany; Healthy Volunteers; Humans; Male; Omeprazole; Polymorphism, Single Nucleotide; Young Adult | 2016 |
Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects.
Topics: Adult; Aged; Aged, 80 and over; Caffeine; Chenodeoxycholic Acid; Cholangitis; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Female; Healthy Volunteers; Humans; Male; Midazolam; Middle Aged; Omeprazole; Rosuvastatin Calcium; Warfarin | 2017 |
[Change of hepatic drug metabolism enzymes in rat depression model with kidney-yang deficiency].
Topics: Animals; Chlorzoxazone; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Depression; Dextromethorphan; Hydrocortisone; Liver; Midazolam; Omeprazole; Rats; Tandem Mass Spectrometry; Theophylline; Tolbutamide; Yang Deficiency | 2017 |
A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Liver-Specific Organic Anion Transporter 1; Losartan; Male; Midazolam; Omeprazole; Panax; Plant Preparations; Random Allocation; Young Adult | 2018 |
Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations.
Topics: Administration, Oral; Adult; Caffeine; Clinical Trials as Topic; Computer Simulation; Cytochrome P-450 Enzyme System; Dextromethorphan; Down-Regulation; Drug Development; Drug Interactions; Female; Humans; Interleukin-6; Male; Midazolam; Middle Aged; Models, Biological; Neuromyelitis Optica; Omeprazole; Rare Diseases; Serum Albumin, Human; Simvastatin; Warfarin | 2019 |
Modulation of CYP450 Activities in Patients With Type 2 Diabetes.
Topics: Adult; Aged; Bupropion; Caffeine; Case-Control Studies; Chlorzoxazone; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diabetes Mellitus, Type 2; Female; Humans; Interferon-gamma; Interleukin-1beta; Interleukin-6; Male; Midazolam; Middle Aged; Omeprazole; Tolbutamide; Tumor Necrosis Factor-alpha | 2019 |
An improved cytochrome P450 phenotyping cocktail with a simplified and highly sensitive UHPLC-MS/MS assay in human plasma.
Topics: Biosensing Techniques; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Interactions; Humans; Limit of Detection; Losartan; Midazolam; Omeprazole; Phenotype; Sensitivity and Specificity; Tandem Mass Spectrometry | 2020 |
Drug interaction potential of high-dose rifampicin in patients with pulmonary tuberculosis.
Topics: Adult; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Digoxin; Drug Interactions; Humans; Midazolam; Omeprazole; Rifampin; Tolbutamide; Tuberculosis, Pulmonary | 2023 |