omeprazole and clopidogrel

omeprazole has been researched along with clopidogrel in 109 studies

Research

Studies (109)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	19 (17.43)	29.6817
2010's	83 (76.15)	24.3611
2020's	7 (6.42)	2.80

Authors

Authors	Studies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chang, CM; Chen, WH; Ng, FH; Wong, BC; Wong, SY	1
Cryer, B	1
Abgrall, JF; Arnaud, B; Boschat, J; Gilard, M; Le Gal, G	1
Arnesen, Ø; Riis, JS	1
Abgrall, JF; Arnaud, B; Boschat, J; Cornily, JC; Gilard, M; Lacut, K; Le Calvez, G; Le Gal, G; Mansourati, J; Mottier, D	1
Gurbel, PA; Lau, WC; Tantry, US	1
Christ, G; Jilma, B; Kreiner, G; Lang, IM; Siller-Matula, JM; Spiel, AO	1
Goto, S; Serebruany, V	1
Braun, S; Hadamitzky, M; Kastrati, A; Morath, T; Schömig, A; Sibbing, D; Stegherr, J; Vogt, W; von Beckerath, N	1
Chen, BL; Chen, Y; Fan, L; Hu, DL; Li, Q; Li, YL; Ouyang, DS; Tan, ZR; Tu, JH; Wang, D; Wang, LS; Zhang, W; Zhou, HH	1
Bouman, HJ; Taubert, D; van Werkum, JW	1
Bredenoord, AJ; ten Berg, JM; van Werkum, JW	1
Mathews, KD; Norgard, NB; Wall, GC	1
Friesen, MH	1
Mihoubi, A; Tho, A	1
Alessi, MC; Bali, L; Bonnet, JL; Brissy, O; Cuisset, T; Frere, C; Gaborit, B; Morange, PE; Poyet, R; Quilici, J	1
Farid, NA; Hagihara, K; Ikeda, T; Ishizuka, T; Kazui, M; Kurihara, A; Nishiya, Y; Okazaki, O	1
Hennekens, C; Laine, L	1
Bretagne, JF	1
Herszényi, L; Juhász, M; Tulassay, Z	1
Bhatt, DL; Depta, JP	1
Jeong, JW; Kim, NH; Oh, SK; Park, HY; Rhee, SJ; Yoo, NJ; Yun, KH	1
Adamopoulou, EN; Argyrakis, SK; Fakiolas, CN; Foussas, SG; Georgilas, AT; Kontos, CF; Patsourakos, NG; Tsiaousis, GZ; Vogiatzidis, K; Zairis, MN	1
Andrén, L; Wall, U	1
Chua, D; Jung, J; Lo, A	1
Börgel, J; Endres, HG; Engelhardt, A; Krüger, JC; Lask, S; Mügge, A; Neubauer, H	1
Alkhatib, AA; Elkhatib, FA; Khatib, OF	1
Bottheim, H; Gross, M; Holinski-Feder, E; Kenngott, S; Kollmer, M; Laner, A; Olze, R	1
Nathisuwan, S; Panomvana, D; Sansanayudh, N; Siriswangvat, S	1
Angiolillo, DJ; Bergougnan, L; Cheng, S; Dubar, M; Gibson, CM; Hurbin, F; LaCreta, FP; Nicolas, O; Ollier, C; Perrin, L	1
Angiolillo, DJ; Bass, TA; Capodanno, D; Charlton, RK; Darlington, A; Desai, B; Dharmashankar, K; Ferreiro, JL; Ueno, M	1
Bhatt, DL; Cannon, CP; Cohen, M; Contant, CF; Cryer, BL; Goldsmith, MA; Laine, L; Lanas, A; Lapuerta, P; Murphy, SA; Schnitzer, TJ; Scirica, BM; Shook, TL	1
Pai, RG; Tafreshi, J; Tran, M	1
Kandulski, A; Malfertheiner, P; Venerito, M	1
Cai, J; Fan, L; Liu, CF; Sun, J; Wang, ZG; Wu, Q	1
Southworth, MR; Temple, R	1
Danikiewicz, A; Hudzik, B; Lekston, A; Polonski, L; Romanowski, W; Szkodzinski, J; Wilczek, K; Zubelewicz-Szkodzinska, B	1
Vassiliou, V	1
Laine, L	1
Juurlink, DN	1
Ford, AC; Sadek, A	1
Giraldo-Giraldo, C; Machado-Alba, JE; Moncada-Escobar, JC	1
Chyrchel, B; Chyrchel, M; Dubiel, JS; Dudek, D; Surdacki, A	1
Boura, J; Harjai, KJ; Mehta, RH; Orshaw, P; Shenoy, C; Usmani, S	1
Hiraishi, H; Kanke, K; Maeda, M; Sasai, T; Shimada, T	1
Albuquerque, A; Araújo, C; Fontes-Carvalho, R; Pimentel-Nunes, P; Ribeiro, VG	1
Chen, JS; Chen, L; Chen, YD; Guo, YS; Huang, TT; Liu, HB; Ren, YH; Sun, ZJ; Wang, CY; Wang, Y; Xie, YJ; Zhao, M	1
Keller, DL	1
Boot, H; de Boer, A; Deneer, VH; Harmsze, AM; Heringa, M; le Comte, M; Mol, PG; Schalekamp, T; Verduijn, MM; Verheugt, FW	1
Buckley, DB; Kazmi, F; Ogilvie, BW; Paris, BL; Parkinson, A; Rostami-Hodjegan, A; Toren, P; Yerino, P	1
Htun, WW; Huang, Y; Ko, W; Kwan, J; Kwan, TW	1
Chen, PF; Hsiao, FY; Huang, WF; Mullins, CD; Tsai, YW; Wen, YW	1
Amariles, P; Ceballos, M; Holguín, H	1
Abraham, NS	1
Boulenc, X; Brian, W; Djebli, N; Hurbin, F; Perrin, L; Shi, J; Van Horn, R	1
Gammack, JK; Messinger-Rapport, BJ; Morley, JE; Thomas, DR	1
Antonino, M; Bliden, KP; Fort, J; Gesheff, M; Gurbel, PA; Plachetka, JR; Tantry, US; Zhang, Y	1
Harrison, RW; Mahaffey, KW	1
Azab, AN; Friger, M; Gilutz, H; Shmulevich, E	1
Kwok, CS; Loke, YK	1
Chen, J; Howden, CW; Leontiadis, GI; Yuan, YC	1
Hashimoto, E; Izuhara, C; Kaneko, S; Takayama, S; Takeuchi, K; Yamada, N; Yamanaka, S	1
Bhatt, DL; Brooks, JK; Frelinger, AL; Lee, RD; Michelson, AD; Mulford, DJ; Nigam, A; Nudurupati, S; Wu, J	1
Horiuchi, H; Ikeda, T; Imai, M; Jinnai, T; Kato, Y; Kimura, T; Makiyama, T; Shirakawa, R; Tada, T; Tazaki, J; Yamane, K	1
Endo, T; Fukui, K; Hibi, K; Himeno, H; Kimura, K; Morita, S; Sugano, T; Tsukahara, K; Umemura, S; Yano, H	1
Lu, FM; Mao, YM; Tong, ZL; Wu, DY; Xu, J	1
Horiuchi, H	1
Chen, YF; Dang, DS; Liu, Q; Shi, GB; Yan, M; Zhao, QC	1
Duh, D; Tanret, I	1
Antonino, M; Bliden, KP; Chai, S; Fort, JG; Gesheff, M; Gesheff, T; Gurbel, PA; Jeong, YH; Shuldiner, A; Tantry, US; Zhang, Y	1
Banahan, BF; Bentley, JP; Datar, MV; Mahabaleshwarkar, RK; Null, KD; Strum, MW; Yang, Y	1
Abramowitz, Y; Arbel, Y; Banai, S; Berliner, S; Birati, EY; Deutsch, V; Finkelstein, A; Halkin, A; Herz, I; Keren, G; Kletzel, H	1
Coleman, JJ; Dhami, A; Hodson, J; McIlroy, G; Thomas, SK	1
D'Ugo, E; De Caterina, R; Rossi, S	1
Azizi, M; Ducint, D; Funck-Brentano, C; Gaussem, P; Molimard, M; Remones, V; Steichen, O; Szymezak, J	1
Juurlink, D	1
Bhatt, DL	1
Chen, G; Du, Y; Hang, L; Ma, B	1
Amariles, P; Angulo, NY; Betancourth, PM; Ceballos, M; Holguín, H	1
Al-Tannir, M; Bahamid, R; Kashour, T	1
Antoku, Y; Hanatani, T; Hori, K; Kawakami, J; Kimura, M; Nakashima, N; Ohe, K; Sai, K; Saito, Y; Segawa, K; Tohkin, M; Yokoi, H	1
Andersson, T; Galbraith, H; Nagy, P; Niazi, M; Nylander, S; Ranjan, S; Wallentin, L	1
El Rouby, N; Goldstein, JA; Johnson, JA; Langaee, TY; Markowitz, JS; Wang, X; Zhu, HJ	1
Bertino, JS	1
Bilker, WB; Brensinger, CM; Flockhart, DA; Freeman, CP; Hennessy, S; Kasner, SE; Kimmel, SE; Leonard, CE	1
Bhatt, DL; Cannon, CP; Cohen, M; Cryer, BL; Doros, G; Goldsmith, MA; Laine, L; Lanas, A; Lapuerta, P; Liu, Y; McIntosh, AI; Schnitzer, TJ; Vardi, M	1
Cayla, G; Collet, JP; Finzi, J; Hulot, JS; Montalescot, G; Simon, N	1
Ford, NF	1
Barbeau, G; Bertrand, OF; De Larochellière, R; Déry, JP; Déry, U; Gleeton, O; Harvey, A; Larose, É; Modak, A; Nguyen, CM; Noël, B; Paradis, JM; Proulx, G; Rinfret, S; Rodés-Cabau, J; Roy, L; Roy, M	1
Bhatt, DL; Cannon, CP; Cohen, M; Cryer, BL; Doros, G; Goldsmith, MA; Hsieh, WH; Laine, L; Lanas, A; Lapuerta, P; Liu, Y; Schnitzer, TJ; Shook, TL; Vaduganathan, M	2
D'Amico, EA; Filho, CC; Filho, RK; Freire, BT; Furtado, RHM; Giugliano, RP; Neto, PAL; Nicolau, JC; Pereira, AC; Ramires, JAF; Rocha, TR; Strunz, CMC	1
Fort, JG; Han, Y; Schofield, D; Tursi, JP; Zhang, W	1
Kruik, HJ; Kruik-Kollöffel, WJ; Movig, KLL; van der Palen, J; van Herk-Sukel, MPP	1
Lohitnavy, M; Lohitnavy, O; Morasuk, T; Tangamornsuksan, W; Thiansupornpong, P	1
Jirungda, S; Komanasin, N; Leuangwatthananon, W; Pussadhamma, B; Senthong, V	1
Munthe, DHB; Sargo, SS; Yogiarto, M	1
Chan, MY; Chew, NWS; Dan, YY; Foo, LL; Ho, KY; Lee, CH; Lim, LG; Low, AF; Muthiah, MD; Richards, AM; Tan, HC; Xiao, J; Yip, JWL; Zheng, H	1
Albuquerque, FC; Baranoski, JF; Catapano, JS; Cole, TS; Ducruet, AF; Fredrickson, VL; Lundberg, JN; Rahmani, R; Rutledge, C; Srinivasan, VM; Wakim, AA	1
Cao, X; Chen, C; Chen, L; Liu, Y; Miao, Y; Niu, J; Sun, Y; Wei, J; Wu, T; Xu, Z	1
Denda, M; Goda, M; Hamano, H; Higashionna, T; Ishizawa, K; Lin, TJ; Miyata, K; Nawa, H; Neishi, M; Niimura, T; Yagi, K; Zamami, Y	1
Häyrynen, S; Kiiski, JI; Niemi, M; Ramste, M; Ritvos, M; Sinisalo, J	1

Reviews

17 review(s) available for omeprazole and clopidogrel

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Drug-drug interaction between clopidogrel and the proton pump inhibitors. The Annals of pharmacotherapy, 2009, Volume: 43, Issue:7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aryl Hydrocarbon Hydroxylases; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2009
Proton pump inhibitor and clopidogrel interaction: fact or fiction? The American journal of gastroenterology, 2010, Volume: 105, Issue:1 Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine	2010
[Prevention of GI bleeding due to antiplatelet agents: a labyrinth!]. Presse medicale (Paris, France : 1983), 2009, Volume: 38, Issue:12 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Lansoprazole; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Risk Factors; Ticlopidine	2009
Current standings of the proton pump inhibitor and clopidogrel co-therapy: review on an evolving field with the eyes of the gastroenterologist. Digestion, 2010, Volume: 81, Issue:1 Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Gastroenterology; Gastrointestinal Hemorrhage; Humans; Myocardial Infarction; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Ticlopidine	2010
Review article: combination of clopidogrel and proton pump inhibitors: implications for clinicians. Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:4 Topics: Aryl Hydrocarbon Hydroxylases; Cardiovascular Diseases; Clinical Trials as Topic; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Humans; Myocardial Infarction; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Stroke; Ticlopidine; Treatment Outcome	2010
[Dilemma between gastroprotection and cardiovascular prevention]. Deutsche medizinische Wochenschrift (1946), 2010, Volume: 135, Issue:44 Topics: Alleles; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Aspirin; Clopidogrel; Coronary Artery Disease; Coronary Restenosis; Cytochrome P-450 CYP2C19; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Drug-Eluting Stents; Humans; Long-Term Care; Mutation; Omeprazole; Peptic Ulcer Hemorrhage; Platelet Aggregation; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Recurrence; Risk Factors; Survival Analysis; Ticlopidine; Treatment Outcome	2010
[Strategy to manage low dose aspirin-induced gastrointestinal injury]. Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69, Issue:2 Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Famotidine; Gastric Mucosa; Humans; Omeprazole; Peptic Ulcer; Platelet Aggregation Inhibitors; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Proton Pump Inhibitors; Ticlopidine	2011
[Interaction between clopidogrel and proton pump inhibitors]. Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155, Issue:28 Topics: Cardiovascular Diseases; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2011
Prescribing proton pump inhibitor and clopidogrel together: current state of recommendations. Current opinion in gastroenterology, 2011, Volume: 27, Issue:6 Topics: Clopidogrel; Drug Interactions; Drug Prescriptions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Risk Assessment; Risk Factors; Ticlopidine	2011
Clopidogrel and PPI interaction: clinically relevant or not? Current cardiology reports, 2012, Volume: 14, Issue:1 Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Male; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Thienopyridines; Ticlopidine	2012
Clopidogrel and proton pump inhibitors: is there a significant drug-drug interaction? Canadian journal of cardiovascular nursing = Journal canadien en soins infirmiers cardio-vasculaires, 2011, Volume: 21, Issue:4 Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2011
Effects of proton pump inhibitors on platelet function in patients receiving clopidogrel: a systematic review. Drug safety, 2012, Feb-01, Volume: 35, Issue:2 Topics: Blood Platelets; Clopidogrel; Drug Interactions; Esomeprazole; Humans; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine	2012
Recent safety concerns with proton pump inhibitors. Journal of clinical gastroenterology, 2012, Volume: 46, Issue:2 Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Fractures, Spontaneous; Gastrointestinal Hemorrhage; Humans; Hypercalciuria; Nephrocalcinosis; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Renal Tubular Transport, Inborn Errors; Risk Factors; Ticlopidine; Treatment Outcome	2012
Proton pump inhibitors and clopidogrel: an association to avoid? Internal and emergency medicine, 2014, Volume: 9, Issue:1 Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Lansoprazole; Monitoring, Physiologic; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2014
Clopidogrel and Genotyping. The Journal of invasive cardiology, 2015, Volume: 27, Issue:8 Topics: Acute Coronary Syndrome; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Genotype; Humans; Omeprazole; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Risk Factors; Stents; Ticlopidine	2015
Outcomes of a multi-ethnic Asian population on combined treatment with clopidogrel and omeprazole in 12,440 patients. Journal of thrombosis and thrombolysis, 2021, Volume: 52, Issue:3 Topics: Asian People; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Ethnicity; Humans; Myocardial Infarction; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Stroke; Ticlopidine	2021

Trials

31 trial(s) available for omeprazole and clopidogrel

Article	Year
Clopidogrel plus omeprazole compared with aspirin plus omeprazole for aspirin-induced symptomatic peptic ulcers/erosions with low to moderate bleeding/re-bleeding risk -- a single-blind, randomized controlled study. Alimentary pharmacology & therapeutics, 2004, Feb-01, Volume: 19, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Omeprazole; Peptic Ulcer; Peptic Ulcer Hemorrhage; Risk Factors; Single-Blind Method; Ticlopidine	2004
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study. Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3 Topics: Aged; Angioplasty, Balloon, Coronary; Cell Adhesion Molecules; Clopidogrel; Double-Blind Method; Drug Antagonism; Drug Therapy, Combination; Female; Humans; Male; Microfilament Proteins; Middle Aged; Myocardial Infarction; Omeprazole; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Stents; Ticlopidine	2008
Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms. Journal of clinical pharmacology, 2009, Volume: 49, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Interactions; Drug Therapy, Combination; Genotype; Humans; Hydroxylation; Male; Omeprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Spectrophotometry, Ultraviolet; Sulfoxides; Ticlopidine; Young Adult	2009
Comparison of omeprazole and pantoprazole influence on a high 150-mg clopidogrel maintenance dose the PACA (Proton Pump Inhibitors And Clopidogrel Association) prospective randomized study. Journal of the American College of Cardiology, 2009, Sep-22, Volume: 54, Issue:13 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Stents; Ticlopidine	2009
Effects of omeprazole on the antiplatelet activity of clopidogrel. International heart journal, 2010, Volume: 51, Issue:1 Topics: Adult; Anti-Ulcer Agents; Blood Platelets; Clopidogrel; Cross-Over Studies; Drug Interactions; Female; Humans; Male; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine	2010
Pantoprazole does not influence the antiplatelet effect of clopidogrel-a whole blood aggregometry study after coronary stenting. Journal of cardiovascular pharmacology, 2010, Volume: 56, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Esomeprazole; Female; Humans; Male; Middle Aged; Multivariate Analysis; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Regression Analysis; Stents; Ticlopidine	2010
Comparison between the effect of omeprazole and rabeprazole on the antiplatelet action of clopidogrel. Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:10 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Aged; Aspirin; Clopidogrel; Coronary Artery Disease; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabeprazole; Ticlopidine; Treatment Outcome	2010
Differential effects of omeprazole and pantoprazole on the pharmacodynamics and pharmacokinetics of clopidogrel in healthy subjects: randomized, placebo-controlled, crossover comparison studies. Clinical pharmacology and therapeutics, 2011, Volume: 89, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Female; Half-Life; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prodrugs; Proton Pump Inhibitors; Ticlopidine; Young Adult	2011
Pharmacodynamic effects of concomitant versus staggered clopidogrel and omeprazole intake: results of a prospective randomized crossover study. Circulation. Cardiovascular interventions, 2010, Volume: 3, Issue:5 Topics: Adult; Clinical Protocols; Clopidogrel; Drug Incompatibility; Drug Interactions; Female; Humans; Male; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome	2010
Clopidogrel with or without omeprazole in coronary artery disease. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Aged; Aspirin; Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2010
[Impact of different proton pump inhibitors on the antiplatelet activity of clopidogrel in combination with aspirin for patients undergoing coronary stent implantation]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2010, Volume: 26, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Angioplasty, Balloon; Aspirin; Clopidogrel; Coronary Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Aggregation; Postoperative Period; Proton Pump Inhibitors; Stents; Ticlopidine	2010
Effect of omeprazole on the concentration of interleukin-6 and transforming growth factor-β1 in patients receiving dual antiplatelet therapy after percutaneous coronary intervention. European cytokine network, 2010, Volume: 21, Issue:4 Topics: Aged; Anti-Ulcer Agents; Aspirin; Biomarkers; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Therapy, Combination; Female; Follow-Up Studies; Gene Expression Regulation; Humans; Interleukin-6; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Predictive Value of Tests; Ticlopidine; Transforming Growth Factor beta1; Treatment Outcome	2010
Separate dosing of clopidogrel and omeprazole may improve platelet inhibition on dual antiplatelet therapy. International journal of cardiology, 2011, May-19, Volume: 149, Issue:1 Topics: Aged; Cardiovascular Diseases; Clopidogrel; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Omeprazole; Pilot Projects; Platelet Activation; Platelet Aggregation Inhibitors; Ticlopidine	2011
Omeprazole, but not pantoprazole, reduces the antiplatelet effect of clopidogrel: a randomized clinical crossover trial in patients after myocardial infarction evaluating the clopidogrel-PPIs drug interaction. European journal of gastroenterology & hepatology, 2011, Volume: 23, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Blood Platelets; Clopidogrel; Cross-Over Studies; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Myocardial Infarction; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2011
Omeprazole affects clopidogrel efficacy but not ischemic events in patients with acute coronary syndrome undergoing elective percutaneous coronary intervention. Chinese medical journal, 2011, Volume: 124, Issue:6 Topics: Acute Coronary Syndrome; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine	2011
Effects of omeprazole and genetic polymorphism of CYP2C19 on the clopidogrel active metabolite. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:1 Topics: Adolescent; Adult; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Female; Humans; Male; Microsomes, Liver; Middle Aged; Omeprazole; Polymorphism, Genetic; Ticlopidine	2012
Pharmacodynamic evaluation of clopidogrel plus PA32540: the Spaced PA32540 With Clopidogrel Interaction Gauging (SPACING) study. Clinical pharmacology and therapeutics, 2011, Volume: 90, Issue:6 Topics: Adult; Anti-Ulcer Agents; Aspirin; Clopidogrel; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Interactions; Female; Humans; Least-Squares Analysis; Male; Omeprazole; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Ticlopidine	2011
A randomized, 2-period, crossover design study to assess the effects of dexlansoprazole, lansoprazole, esomeprazole, and omeprazole on the steady-state pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers. Journal of the American College of Cardiology, 2012, Apr-03, Volume: 59, Issue:14 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Area Under Curve; Blood Coagulation; Blood Platelets; Clopidogrel; Confidence Intervals; Cross-Over Studies; Dexlansoprazole; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Lansoprazole; Male; Middle Aged; Omeprazole; Proton Pump Inhibitors; Reference Values; Ticlopidine; Young Adult	2012
Influence of omeprazole and famotidine on the antiplatelet effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes: a prospective, randomized, multicenter study. Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:11 Topics: Acute Coronary Syndrome; Aged; Anti-Ulcer Agents; Aspirin; Blood Platelets; Clopidogrel; Drug Antagonism; Famotidine; Female; Humans; Male; Middle Aged; Myocardial Infarction; Omeprazole; Platelet Aggregation Inhibitors; Platelet Function Tests; Ticlopidine	2012
The influence of omeprazole on platelet inhibition of clopidogrel in various CYP2C19 mutant alleles. Genetic testing and molecular biomarkers, 2012, Volume: 16, Issue:11 Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Aspirin; Blood Platelets; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Male; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Ticlopidine; Young Adult	2012
Spaced administration of PA32540 and clopidogrel results in greater platelet inhibition than synchronous administration of enteric-coated aspirin and enteric-coated omeprazole and clopidogrel. American heart journal, 2013, Volume: 165, Issue:2 Topics: Administration, Oral; Adult; Aspirin; Clopidogrel; Coronary Thrombosis; Cross-Over Studies; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Enzyme Inhibitors; Follow-Up Studies; Gastrointestinal Diseases; Humans; Middle Aged; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Tablets, Enteric-Coated; Ticlopidine; Treatment Outcome	2013
Platelet inhibitory effect of clopidogrel in patients treated with omeprazole, pantoprazole, and famotidine: a prospective, randomized, crossover study. Clinical cardiology, 2013, Volume: 36, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Aspirin; Chi-Square Distribution; Clopidogrel; Cross-Over Studies; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Famotidine; Female; Histamine H2 Antagonists; Humans; Israel; Linear Models; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Single-Blind Method; Ticlopidine; Time Factors; Treatment Outcome	2013
Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers. Archives of cardiovascular diseases, 2013, Volume: 106, Issue:12 Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Blood Platelets; Cell Adhesion Molecules; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C19; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Half-Life; Healthy Volunteers; Humans; Male; Metabolic Clearance Rate; Microfilament Proteins; Omeprazole; Paris; Phosphoproteins; Phosphorylation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Rabeprazole; Ticlopidine	2013
Effect of clopidogrel with or without omeprazole in patients with carotid artery stenting. The West Indian medical journal, 2013, Volume: 62, Issue:2 Topics: Angiography; Aspirin; Breath Tests; Carotid Arteries; Carotid Stenosis; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Female; Gastrointestinal Hemorrhage; Helicobacter Infections; Helicobacter pylori; Humans; Male; Middle Aged; Omeprazole; Peptic Ulcer; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Stents; Ticlopidine	2013
Effect of esomeprazole with/without acetylsalicylic acid, omeprazole and lansoprazole on pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2014, Volume: 14, Issue:3 Topics: Adolescent; Adult; Area Under Curve; Aspirin; Clopidogrel; Cross-Over Studies; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Healthy Volunteers; Humans; Lansoprazole; Male; Middle Aged; Omeprazole; Platelet Aggregation; Proton Pump Inhibitors; Ticlopidine; Young Adult	2014
The effects of proton pump inhibition on patient-reported severity of dyspepsia when receiving dual anti-platelet therapy with clopidogrel and low-dose aspirin: analysis from the Clopidogrel and the Optimization of Gastrointestinal Events Trial. Alimentary pharmacology & therapeutics, 2015, Volume: 42, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Dyspepsia; Female; Gastrointestinal Hemorrhage; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine; Young Adult	2015
Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients. European journal of clinical pharmacology, 2015, Volume: 71, Issue:9 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Alleles; Clopidogrel; Coronary Artery Disease; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Genotype; Humans; Male; Middle Aged; Models, Biological; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2015
Changes in CYP2C19 enzyme activity evaluated by the [(13)C]-pantoprazole breath test after co-administration of clopidogrel and proton pump inhibitors following percutaneous coronary intervention and correlation to platelet reactivity. Journal of breath research, 2016, Jan-27, Volume: 10, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Blood Platelets; Breath Tests; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Esomeprazole; Humans; Omeprazole; Pantoprazole; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Ranitidine; Ticlopidine	2016
Proton-Pump Inhibitors Reduce Gastrointestinal Events Regardless of Aspirin Dose in Patients Requiring Dual Antiplatelet Therapy. Journal of the American College of Cardiology, 2016, Apr-12, Volume: 67, Issue:14 Topics: Aged; Aspirin; Clopidogrel; Dose-Response Relationship, Drug; Drug Therapy, Combination; Dyspepsia; Female; Gastrointestinal Hemorrhage; Humans; Intestinal Obstruction; Intestinal Perforation; Male; Middle Aged; Myocardial Infarction; Myocardial Revascularization; Omeprazole; Pain; Peptic Ulcer; Platelet Aggregation Inhibitors; Prospective Studies; Proton Pump Inhibitors; Stroke; Ticlopidine	2016
Efficacy and Safety of Proton-Pump Inhibitors in High-Risk Cardiovascular Subsets of the COGENT Trial. The American journal of medicine, 2016, Volume: 129, Issue:9 Topics: Acute Coronary Syndrome; Aspirin; Clopidogrel; Double-Blind Method; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome	2016
Drug Interaction Between Clopidogrel and Ranitidine or Omeprazole in Stable Coronary Artery Disease: A Double-Blind, Double Dummy, Randomized Study. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2016, Volume: 16, Issue:4 Topics: Aged; Blood Platelets; Clopidogrel; Coronary Artery Disease; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Ranitidine; Ticlopidine	2016

Other Studies

61 other study(ies) available for omeprazole and clopidogrel

Article	Year
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Reducing the risks of gastrointestinal bleeding with antiplatelet therapies. The New England journal of medicine, 2005, Jan-20, Volume: 352, Issue:3 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Therapy, Combination; Humans; Omeprazole; Peptic Ulcer Hemorrhage; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2005
Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirin. Journal of thrombosis and haemostasis : JTH, 2006, Volume: 4, Issue:11 Topics: Aged; Angioplasty; Aryl Hydrocarbon Hydroxylases; Aspirin; Cell Adhesion Molecules; Clopidogrel; Coronary Disease; Cytochrome P-450 CYP2C19; Drug Antagonism; Enzyme Inhibitors; Female; Humans; Male; Microfilament Proteins; Mixed Function Oxygenases; Omeprazole; Phosphoproteins; Phosphorylation; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymorphism, Single Nucleotide; Protein Processing, Post-Translational; Thrombosis; Ticlopidine	2006
[Platelet inhibition and gastric problems]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2007, Jan-04, Volume: 127, Issue:1 Topics: Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine	2007
Omeprazole: a possible new candidate influencing the antiplatelet effect of clopidogrel. Journal of the American College of Cardiology, 2008, Jan-22, Volume: 51, Issue:3 Topics: Angioplasty, Balloon, Coronary; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Antagonism; Drug Therapy, Combination; Humans; Mixed Function Oxygenases; Omeprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Stents; Ticlopidine	2008
Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrel. American heart journal, 2009, Volume: 157, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Blood Platelets; Clopidogrel; Drug Interactions; Esomeprazole; Female; Humans; Male; Middle Aged; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2009
[Proton pump inhibition: more than only reflux therapy]. MMW Fortschritte der Medizin, 2008, Nov-13, Volume: 150, Issue:46 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Asthma; Chest Pain; Clopidogrel; Comorbidity; Controlled Clinical Trials as Topic; Coronary Disease; Diagnosis, Differential; Drug Therapy, Combination; Gastroesophageal Reflux; Humans; Omeprazole; Platelet Aggregation Inhibitors; Practice Guidelines as Topic; Proton Pump Inhibitors; Rabeprazole; Secondary Prevention; Ticlopidine; Time Factors	2008
Clopidogrel and proton pump inhibitors: gastric protection at expense of vascular benefit? Thrombosis and haemostasis, 2009, Volume: 101, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Humans; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Stents; Ticlopidine	2009
Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel. Thrombosis and haemostasis, 2009, Volume: 101, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Diphosphate; Aged; Angioplasty, Balloon, Coronary; Aspirin; Clopidogrel; Coronary Angiography; Coronary Artery Disease; Cross-Sectional Studies; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Male; Middle Aged; Multivariate Analysis; Omeprazole; Pantoprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Function Tests; Proton Pump Inhibitors; Stents; Ticlopidine	2009
Cytochrome P-450 polymorphisms and response to clopidogrel. The New England journal of medicine, 2009, May-21, Volume: 360, Issue:21 Topics: Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cytochrome P-450 CYP2C19; Humans; Linkage Disequilibrium; Microsomes; Omeprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Ticlopidine	2009
Proton pump inhibitors and clopidogrel: a difficult dilemma. American heart journal, 2009, Volume: 157, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Clopidogrel; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Thrombosis; Ticlopidine	2009
Interaction between clopidogrel and proton pump inhibitors. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2009, Jun-09, Volume: 180, Issue:12 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Case-Control Studies; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Lansoprazole; Myocardial Infarction; Odds Ratio; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Secondary Prevention; Ticlopidine	2009
Do the association of cytochrome P450 interacting drugs, influence clopidogrel efficacity? American heart journal, 2009, Volume: 158, Issue:1 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Blood Platelets; Clopidogrel; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Ticlopidine; Treatment Outcome	2009
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:1 Topics: Antibodies; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Biotransformation; Cell Line; Cell Line, Tumor; Clopidogrel; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Glutathione; Humans; Ketoconazole; Kinetics; Mephenytoin; Microsomes; Microsomes, Liver; NADP; Omeprazole; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Platelet Aggregation Inhibitors; Sulfaphenazole; Theophylline; Ticlopidine	2010
Omeprazole and clopidogrel: Should clinicians be worried? Cleveland Clinic journal of medicine, 2010, Volume: 77, Issue:2 Topics: Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine	2010
The impact of treatment with omeprazole on the effectiveness of clopidogrel drug therapy during the first year after successful coronary stenting. The Canadian journal of cardiology, 2010, Volume: 26, Issue:2 Topics: Administration, Oral; Angina, Unstable; Angioplasty, Balloon, Coronary; Cause of Death; Clopidogrel; Drug Therapy, Combination; Enzyme Inhibitors; Female; Follow-Up Studies; Greece; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Omeprazole; Patient Readmission; Platelet Aggregation Inhibitors; Prospective Studies; Stents; Ticlopidine; Time Factors; Treatment Outcome	2010
[Risky to combine clopidogrel with proton pump inhibitor?]. Lakartidningen, 2009, Dec-22, Volume: 106, Issue:52 Topics: Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Information Services; Drug Interactions; Enzyme Inhibitors; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine	2009
Evidence for interaction between clopidogrel and proton-pump inhibitors. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2010, Apr-15, Volume: 67, Issue:8 Topics: Clopidogrel; Controlled Clinical Trials as Topic; Drug Interactions; Humans; Omeprazole; Platelet Aggregation Inhibitors; Platelet Count; Proton Pump Inhibitors; Ticlopidine; United States; United States Food and Drug Administration	2010
If I take the blood thinner Plavix, should I avoid using Prilosec or other heartburn medications? Mayo Clinic women's healthsource, 2010, Volume: 14, Issue:5 Topics: Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Drug Therapy, Combination; Health Knowledge, Attitudes, Practice; Heartburn; Humans; Myocardial Infarction; Omeprazole; Patient Education as Topic; Platelet Aggregation Inhibitors; Risk Factors; Stroke; Ticlopidine	2010
Controversial warning on Plavix and stomach-protecting medications. Harvard heart letter : from Harvard Medical School, 2010, Volume: 20, Issue:6 Topics: Anti-Ulcer Agents; Clopidogrel; Drug Interactions; Drug Labeling; Health Knowledge, Attitudes, Practice; Humans; Omeprazole; Platelet Aggregation Inhibitors; Stomach Ulcer; Ticlopidine; United States; United States Food and Drug Administration	2010
Gastric acid-reducing medications and clopidogrel: what are the latest FDA recommendations? The American journal of gastroenterology, 2010, Volume: 105, Issue:5 Topics: Anticoagulants; Clopidogrel; Drug Interactions; Endoscopy, Gastrointestinal; Female; Humans; Male; Omeprazole; Proton Pump Inhibitors; Safety Management; Thromboembolism; Ticlopidine; United States; United States Food and Drug Administration	2010
Clopidogrel and proton pump inhibitor (PPI) interaction: separate intake and a non-omeprazole PPI the solution? European journal of medical research, 2010, May-18, Volume: 15, Issue:5 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Ticlopidine	2010
Interaction of clopidogrel and omeprazole. The New England journal of medicine, 2010, Nov-11, Volume: 363, Issue:20 Topics: Cardiovascular Diseases; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2010
In brief: Clopidogrel and omeprazole. The Medical letter on drugs and therapeutics, 2010, Nov-29, Volume: 52, Issue:1352 Topics: Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2010
Double-dose clopidogrel in patients undergoing PCI for ACS. Lancet (London, England), 2011, Jan-22, Volume: 377, Issue:9762 Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Cardiovascular Diseases; Clopidogrel; Drug Interactions; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Randomized Controlled Trials as Topic; Ticlopidine	2011
Proton pump inhibitor co-therapy with clopidogrel: is there GI benefit or cardiovascular harm? Gastroenterology, 2011, Volume: 140, Issue:3 Topics: Atherosclerosis; Clopidogrel; Drug Interactions; Humans; Omeprazole; Peptic Ulcer; Platelet Aggregation; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Assessment; Secondary Prevention; Ticlopidine; Time Factors; Treatment Outcome	2011
Clopidogrel with or without omeprazole in coronary disease. The New England journal of medicine, 2011, 02-17, Volume: 364, Issue:7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Cardiovascular Diseases; Chemistry, Pharmaceutical; Clopidogrel; Coronary Artery Disease; Drug Interactions; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2011
Clopidogrel with or without omeprazole in coronary disease. The New England journal of medicine, 2011, 02-17, Volume: 364, Issue:7 Topics: Clopidogrel; Coronary Artery Disease; Cost-Benefit Analysis; Drug Therapy, Combination; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2011
[Active pharmacosurveillance of patients affiliated to the Colombian general social security/health system]. Revista de salud publica (Bogota, Colombia), 2010, Volume: 12, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Calcium Channel Blockers; Clopidogrel; Colombia; Diphosphonates; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Imidazoles; Losartan; Medication Systems; Metoprolol; National Health Programs; Omeprazole; Retrospective Studies; Social Security; Software; Ticlopidine; Zoledronic Acid	2010
Clinical outcomes in patients with the concomitant use of clopidogrel and proton pump inhibitors after percutaneous coronary intervention: an analysis from the Guthrie Health Off-Label Stent (GHOST) investigators. Circulation. Cardiovascular interventions, 2011, Apr-01, Volume: 4, Issue:2 Topics: Aged; Angioplasty, Balloon, Coronary; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proportional Hazards Models; Proton Pump Inhibitors; Stents; Ticlopidine; Treatment Outcome	2011
Coadministration of clopidogrel and proton pump inhibitors. Cleveland Clinic journal of medicine, 2011, Volume: 78, Issue:5 Topics: Clopidogrel; Drug Interactions; Drug Therapy, Combination; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2011
The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:11 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Drug Interactions; Enzyme Inhibitors; Esomeprazole; Hepatocytes; Humans; Inhibitory Concentration 50; Lansoprazole; Microsomes; Microsomes, Liver; Omeprazole; Pantoprazole; Protein Binding; Proton Pump Inhibitors; Recombinant Proteins; Ticlopidine	2011
Effect of proton pump inhibitors on platelet inhibition activity of clopidogrel in Chinese patients with percutaneous coronary intervention. Vascular health and risk management, 2011, Volume: 7 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Asian; Asian People; Blood Platelets; China; Clopidogrel; Drug Resistance; Esomeprazole; Female; Humans; Lansoprazole; Male; Middle Aged; New York City; Omeprazole; Platelet Aggregation Inhibitors; Platelet Function Tests; Prospective Studies; Proton Pump Inhibitors; Stents; Thrombosis; Ticlopidine; Time Factors	2011
Relationship between cardiovascular outcomes and proton pump inhibitor use in patients receiving dual antiplatelet therapy after acute coronary syndrome. Pharmacoepidemiology and drug safety, 2011, Volume: 20, Issue:10 Topics: Acute Coronary Syndrome; Aged; Aryl Hydrocarbon Hydroxylases; Aspirin; Cardiovascular Diseases; Clopidogrel; Cohort Studies; Cytochrome P-450 CYP2C19; Databases, Factual; Drug Interactions; Esomeprazole; Female; Herb-Drug Interactions; Hospitalization; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Retrospective Studies; Ticlopidine; Treatment Outcome	2011
[Clinical importance of the clopidogrel - omeprazole interaction: a question to solve]. Atencion primaria, 2012, Volume: 44, Issue:3 Topics: Clopidogrel; Controlled Clinical Trials as Topic; Drug Interactions; Gastrointestinal Hemorrhage; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2012
Clinical update on nursing home medicine: 2011. Journal of the American Medical Directors Association, 2011, Volume: 12, Issue:9 Topics: Anti-Ulcer Agents; Anticoagulants; Atrial Fibrillation; Clopidogrel; Clostridioides difficile; Delirium; Diabetes Complications; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; Fractures, Bone; Geriatric Nursing; Humans; Male; Nursing Homes; Omeprazole; Osteoporosis; Peptic Ulcer; Platelet Aggregation Inhibitors; Pneumonia, Bacterial; Polypharmacy; Proton Pump Inhibitors; Risk Factors; Ticlopidine; Warfarin; Weight Loss	2011
A new model of gastric bleeding induced in rats by aspirin plus clopidogrel under stimulation of acid secretion. Prophylactic effects of antiulcer drugs. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2012, Volume: 63, Issue:1 Topics: Animals; Anti-Ulcer Agents; Aspirin; Clopidogrel; Drug Interactions; Famotidine; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Male; Omeprazole; Peroxidase; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Ticlopidine	2012
Effects of PPIs and an H2 blocker on the antiplatelet function of clopidogrel in Japanese patients under dual antiplatelet therapy. Journal of atherosclerosis and thrombosis, 2012, Volume: 19, Issue:6 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Asian People; Aspirin; Case-Control Studies; Clopidogrel; Coronary Artery Disease; Cross-Over Studies; Drug Therapy, Combination; Enzyme Inhibitors; Female; Histamine H2 Antagonists; Humans; Male; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Prognosis; Prospective Studies; Proton Pump Inhibitors; Rabeprazole; Ticlopidine	2012
[Impact of proton pump inhibitor omeprazole on the antiplatelet effect of clopidogrel in individuals with various CYP2C192 genotypes]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2012, Volume: 29, Issue:4* Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2012
Proton-pump inhibitors could be innocent when used concomitantly with clopidogrel. Circulation journal : official journal of the Japanese Circulation Society, 2012, Volume: 76, Issue:11 Topics: Acute Coronary Syndrome; Anti-Ulcer Agents; Aspirin; Blood Platelets; Clopidogrel; Famotidine; Female; Humans; Male; Omeprazole; Platelet Aggregation Inhibitors; Ticlopidine	2012
[Comment of the Delphi Care editors on Critical evaluation of interaction screening software available in pharmacies]. Journal de pharmacie de Belgique, 2012, Issue:4 Topics: Anti-Bacterial Agents; Aromatase Inhibitors; Clopidogrel; Contraceptives, Oral; Delphi Technique; Drug Interactions; Estrogens; Female; Humans; Omeprazole; Pharmacies; Pharmacists; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Software; Ticlopidine	2012
Risk of adverse cardiovascular outcomes and all-cause mortality associated with concomitant use of clopidogrel and proton pump inhibitors in elderly patients. Current medical research and opinion, 2013, Volume: 29, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Cohort Studies; Coronary Artery Bypass; Drug Interactions; Drug Therapy, Combination; Esomeprazole; Female; Humans; Lansoprazole; Male; Myocardial Infarction; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Rabeprazole; Risk; Stroke; Ticlopidine	2013
The impact of direct healthcare professional communication on prescribing practice in the UK hospital setting: an interrupted time series analysis. Drug safety, 2013, Volume: 36, Issue:7 Topics: Adverse Drug Reaction Reporting Systems; Antipsychotic Agents; Clopidogrel; Communication; Dementia; Drug Interactions; Drug Prescriptions; Health Personnel; Hospitals; Humans; Omeprazole; Practice Patterns, Physicians'; Proton Pump Inhibitors; Ticlopidine; United Kingdom	2013
Clopidogrel and proton pump inhibitors. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014, Feb-18, Volume: 186, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acute Coronary Syndrome; Clinical Trials as Topic; Clopidogrel; Drug Combinations; Drug Interactions; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2014
Clopidogrel and proton pump inhibitors. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2014, Feb-18, Volume: 186, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Clopidogrel; Humans; Omeprazole; Pantoprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2014
[Effect of drug interaction between clopidogrel and omeprazole in hospital readmision of patients by a recurrent acute coronary syndrome: a case-control study]. Atencion primaria, 2014, Volume: 46, Issue:8 Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Case-Control Studies; Clopidogrel; Drug Interactions; Female; Humans; Male; Middle Aged; Omeprazole; Patient Readmission; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Recurrence; Ticlopidine	2014
Changing prescription pattern of omeprazole among patients receiving clopidogrel. International heart journal, 2014, Volume: 55, Issue:2 Topics: Clopidogrel; Drug Interactions; Drug Prescriptions; Drug Therapy, Combination; Follow-Up Studies; Gastrointestinal Diseases; Humans; Myocardial Ischemia; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Retrospective Studies; Ticlopidine	2014
Evaluation of two Japanese regulatory actions using medical information databases: a 'Dear Doctor' letter to restrict oseltamivir use in teenagers, and label change caution against co-administration of omeprazole with clopidogrel. Journal of clinical pharmacy and therapeutics, 2014, Volume: 39, Issue:4 Topics: Adolescent; Age Factors; Antiviral Agents; Child; Clopidogrel; Databases, Factual; Drug and Narcotic Control; Drug Interactions; Humans; Interrupted Time Series Analysis; Japan; Omeprazole; Oseltamivir; Pharmacovigilance; Platelet Aggregation Inhibitors; Practice Patterns, Physicians'; Proton Pump Inhibitors; Regression Analysis; Ticlopidine; Young Adult	2014
The influence of the CYP2C1910 allele on clopidogrel activation and CYP2C192 genotyping. Pharmacogenetics and genomics, 2014, Volume: 24, Issue:8 Topics: Alleles; Aryl Hydrocarbon Hydroxylases; Catalysis; Chromatography, Liquid; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Humans; Kinetics; Mephenytoin; Omeprazole; Pharmacogenetics; Polymorphism, Single Nucleotide; Sequence Analysis, DNA; Tandem Mass Spectrometry; Ticlopidine	2014
The clopidogrel conundrum. Journal of clinical pharmacology, 2014, Volume: 54, Issue:8 Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Drug Interactions; Esomeprazole; Genotype; Humans; Omeprazole; Platelet Aggregation Inhibitors; Polymorphism, Genetic; Proton Pump Inhibitors; Ticlopidine; Treatment Outcome	2014
Comparative risk of ischemic stroke among users of clopidogrel together with individual proton pump inhibitors. Stroke, 2015, Volume: 46, Issue:3 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Brain Ischemia; Clopidogrel; Data Interpretation, Statistical; Drug Therapy, Combination; Esomeprazole; Female; Humans; Lansoprazole; Male; Middle Aged; Omeprazole; Pantoprazole; Proportional Hazards Models; Proton Pump Inhibitors; Rabeprazole; Retrospective Studies; Risk; Stroke; Ticlopidine	2015
The budget impact of using enteric-coated aspirin 325 mg + immediate-release omeprazole 40 mg to prevent recurrent cardiovascular events. Journal of medical economics, 2017, Volume: 20, Issue:6 Topics: Adult; Aged; Aspirin; Budgets; Cardiovascular Diseases; Clopidogrel; Drug Combinations; Female; Gastrointestinal Diseases; Humans; Male; Markov Chains; Medication Adherence; Middle Aged; Models, Econometric; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Secondary Prevention; Ticlopidine	2017
Drug interaction: Clopidogrel and PPIs. The Medical letter on drugs and therapeutics, 2017, 02-27, Volume: 59, Issue:1515 Topics: Clopidogrel; Drug Interactions; Esomeprazole; Humans; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Risk Factors; Ticlopidine	2017
Decrease in Switches to 'Unsafe' Proton Pump Inhibitors After Communications About Interactions with Clopidogrel. Clinical drug investigation, 2017, Volume: 37, Issue:8 Topics: Aged; Clopidogrel; Drug Interactions; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Ticlopidine	2017
A pharmacokinetic model of drug-drug interaction between clopidogrel and omeprazole at CYP2C19 in humans. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2017, Volume: 2017 Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Drug Interactions; Humans; Omeprazole; Ticlopidine	2017
Interaction of CYP2C19 G681A polymorphism and omeprazole on clopidogrel responsiveness and impact in patients with acute coronary syndrome. Coronary artery disease, 2020, Volume: 31, Issue:3 Topics: Acute Coronary Syndrome; Aged; Clopidogrel; Cross-Sectional Studies; Cytochrome P-450 CYP2C19; Drug Interactions; Female; Humans; Logistic Models; Male; Middle Aged; Omeprazole; Pharmacogenomic Testing; Platelet Aggregation Inhibitors; Platelet Function Tests; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Proton Pump Inhibitors; ROC Curve; Thailand; Treatment Outcome	2020
Antiaggregation effect of clopidogrel in coronary heart disease patients using omeprazole. Journal of basic and clinical physiology and pharmacology, 2020, Jan-25, Volume: 30, Issue:6 Topics: Adult; Anti-Ulcer Agents; Clopidogrel; Coronary Disease; Female; Humans; Male; Middle Aged; Omeprazole; Platelet Aggregation; Platelet Aggregation Inhibitors; Prospective Studies; Treatment Outcome; Young Adult	2020
Omeprazole-clopidogrel interaction and neurovascular complications after flow-diverter device placement. Journal of neurointerventional surgery, 2022, Volume: 14, Issue:4 Topics: Blood Platelets; Clopidogrel; Humans; Omeprazole; Platelet Aggregation Inhibitors; Retrospective Studies	2022
Study on the Interaction between Deuterium Clopidogrel and Omeprazole. Pharmacology, 2022, Volume: 107, Issue:5-6 Topics: Clopidogrel; Cytochrome P-450 CYP2C19; Deuterium; Drug Interactions; Drug Therapy, Combination; Humans; Isoenzymes; Omeprazole; Platelet Aggregation Inhibitors; Proton Pump Inhibitors; Tandem Mass Spectrometry; Ticlopidine	2022
Structural characterization of the optical isomers esomeprazole and omeprazole using the JADER and FAERS databases. Toxicology and applied pharmacology, 2023, 09-15, Volume: 475 Topics: Adverse Drug Reaction Reporting Systems; Cilostazol; Clopidogrel; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Esomeprazole; Hemorrhage; Humans; Omeprazole; Prasugrel Hydrochloride; United States	2023
CYP2C19 loss-of-function alleles and use of omeprazole or esomeprazole increase the risk of cardiovascular outcomes in patients using clopidogrel. Clinical and translational science, 2023, Volume: 16, Issue:10 Topics: Alleles; Clopidogrel; Cytochrome P-450 CYP2C19; Esomeprazole; Genotype; Humans; Omeprazole; Platelet Aggregation Inhibitors; Prospective Studies; Stroke; Treatment Outcome	2023