omeprazole has been researched along with acetaminophen in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (20.00) | 18.2507 |
| 2000's | 12 (34.29) | 29.6817 |
| 2010's | 15 (42.86) | 24.3611 |
| 2020's | 1 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bharate, SS; Vishwakarma, RA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Hurwitz, A; Parkinson, A | 1 |
| Andersson, T; Berlin, RG; Carlsson, E; Castagnoli, N; Lu, A; Moldéus, P | 1 |
| Petersen, KU | 2 |
| Bartoli, A; Cipolla, G; Crema, F; Gatti, G; Perucca, E; Xiaodong, S | 1 |
| Adams, S; al-Sayegh, F; Goldstein, J; Kalhorn, T; Magee, S; Nelson, S; Sarich, T; Slattery, J; Wright, J | 1 |
| Enatsu, I; Hanada, Y; Kuyama, Y; Makino, H; Mineshita, S; Qi, J; Sanaka, M; Tanaka, H; Yamanaka, M | 1 |
| Ma, L; Ruan, Q; Wen, B; Zhu, M | 1 |
| Her, C | 1 |
| Berger-Gryllaki, M; Buclin, T; Pannatier, A; Podilsky, G; Roulet, M; Testa, B | 1 |
| Miller, GP | 1 |
| Cutfield, NI; Tong, DC | 1 |
| Bradfield, CA; Johnson, BP; Sengupta, S; Stewart, R; Swanson, SA; Thomson, JA | 1 |
| Ladizinski, B; Sankey, C | 1 |
| Harris, G; Landesmann, B; Mennecozzi, M; Palosaari, T; Whelan, M | 1 |
| Arakawa, H; Itoh, M; Kojima, H; Koyama, S; Masuda, N; Ogihara, T; Yano, K | 1 |
| Hilmer, SN; Mach, J; Wang, X | 1 |
4 review(s) available for omeprazole and acetaminophen
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Omeprazole and the induction of human cytochrome P-450: a response to concerns about potential adverse effects.
Topics: Acetaminophen; Carcinogens; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Omeprazole; Phenacetin | 1991 |
Review article: omeprazole and the cytochrome P450 system.
Topics: Acetaminophen; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Humans; Omeprazole; Oxidoreductases; Proton Pump Inhibitors; Receptors, Aryl Hydrocarbon; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 1995 |
[Omeprazole and the cytochrome P450 system of the liver].
Topics: Acetaminophen; Carcinogenicity Tests; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Humans; Inactivation, Metabolic; Liver; Omeprazole; Oxidoreductases; Peptic Ulcer | 1993 |
2 trial(s) available for omeprazole and acetaminophen
| Article | Year |
|---|---|
Pharmacokinetic interaction between acetaminophen and lansoprazole.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetaminophen; Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Drug Interactions; Enzyme Inhibitors; Gastric Emptying; Humans; Lansoprazole; Male; Omeprazole; Proton Pump Inhibitors; Reference Values | 1999 |
The bioavailability of bromazepam, omeprazole and paracetamol given by nasogastric feeding tube.
Topics: Acetaminophen; Administration, Oral; Analgesics, Non-Narcotic; Anti-Anxiety Agents; Anti-Ulcer Agents; Area Under Curve; Biological Availability; Bromazepam; Cohort Studies; Cross-Over Studies; Female; Half-Life; Humans; Intubation, Gastrointestinal; Male; Metabolic Clearance Rate; Omeprazole; Prospective Studies; Reproducibility of Results; Therapeutic Equivalency | 2009 |
29 other study(ies) available for omeprazole and acetaminophen
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics | 2015 |
P450/losec.
Topics: Acetaminophen; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Omeprazole; Oxidoreductases | 1991 |
Omeprazole does not enhance the metabolism of phenacetin, a marker of CYP1A2 activity, in healthy volunteers.
Topics: Acetaminophen; Adult; Biomarkers; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Half-Life; Humans; Male; Omeprazole; Oxidoreductases; Phenacetin | 1994 |
The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Ulcer Agents; Anticonvulsants; Female; Humans; Male; Mephenytoin; Middle Aged; Omeprazole; Phenotype; Reference Values | 1997 |
Rapid screening of glutathione-trapped reactive metabolites by linear ion trap mass spectrometry with isotope pattern-dependent scanning and postacquisition data mining.
Topics: Acetaminophen; Carbamazepine; Cresols; Diclofenac; Drug Evaluation, Preclinical; Glutathione; Omeprazole; Pharmaceutical Preparations; Phenols; Predictive Value of Tests; Spectrometry, Mass, Electrospray Ionization | 2008 |
Acetaminophen-induced, not desflurane-induced, hepatotoxicity.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthetics, Inhalation; Anti-Ulcer Agents; Chemical and Drug Induced Liver Injury; Cisapride; Cytochrome P-450 Enzyme System; Desflurane; Diagnosis, Differential; Humans; Infant; Isoflurane; Liver; Male; Mobius Syndrome; Omeprazole; Ophthalmologic Surgical Procedures | 2008 |
Warfarin therapy: how the less interesting half just got interesting.
Topics: Acetaminophen; Anticoagulants; Azithromycin; Cimetidine; Cytochrome P-450 Enzyme System; Drug Interactions; Gefitinib; Humans; Omeprazole; Quinazolines; Stereoisomerism; Substrate Specificity; Warfarin | 2010 |
Common medications among dental outpatients: considerations in general dental practice.
Topics: Acetaminophen; Adolescent; Adult; Age Distribution; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antihypertensive Agents; Aspirin; Cilazapril; Dental Clinics; Drug Interactions; Drug Utilization; Female; General Practice, Dental; Humans; Male; Middle Aged; New Zealand; Omeprazole; Outpatients; Polypharmacy; Retrospective Studies; Young Adult | 2012 |
Aggregate culture of human embryonic stem cell-derived hepatocytes in suspension are an improved in vitro model for drug metabolism and toxicity testing.
Topics: Acetaminophen; Cell Aggregation; Cell Culture Techniques; Cell Differentiation; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inducers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Drug Discovery; Embryonic Stem Cells; Enzyme Induction; Hep G2 Cells; Hepatocytes; Humans; Omeprazole; Pluripotent Stem Cells; Rifampin; Tandem Mass Spectrometry; Toxicity Tests | 2014 |
A topical matter: toxic epidermal necrolysis.
Topics: Acetaminophen; Analgesics, Opioid; Anti-Inflammatory Agents; Anticonvulsants; Antiemetics; Antineoplastic Agents; Dacarbazine; Dexamethasone; Drug Combinations; Erythema; gamma-Globulins; Glioblastoma; Humans; Immunologic Factors; Levetiracetam; Male; Methylprednisolone; Middle Aged; Omeprazole; Oxycodone; Piperidines; Piracetam; Proton Pump Inhibitors; Quinazolines; Stevens-Johnson Syndrome; Temozolomide; Wound Healing | 2014 |
Sex differences in liver toxicity-do female and male human primary hepatocytes react differently to toxicants in vitro?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Calcium; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Chlorpromazine; Diclofenac; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Hepatocytes; Humans; Male; Membrane Potential, Mitochondrial; Omeprazole; Primary Cell Culture; Sex Characteristics; Verapamil | 2015 |
Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates.
Topics: Acetaminophen; Adenosine Triphosphate; Arylsulfotransferase; Cell Culture Techniques; Cells, Cultured; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme System; Diclofenac; Glucuronosyltransferase; Hepatocytes; Humans; Lamotrigine; Midazolam; Omeprazole; Rifampin; RNA, Messenger; Triazines | 2018 |
Quantification of serum levels in mice of seven drugs (and six metabolites) commonly taken by older people with polypharmacy.
Topics: Acetaminophen; Aged, 80 and over; Animals; Chromatography, Liquid; Drug Interactions; Frail Elderly; Humans; Metoprolol; Mice; Omeprazole; Oxycodone; Polypharmacy; Reproducibility of Results; Tandem Mass Spectrometry | 2021 |