Page last updated: 2024-09-03

omega-n-methylarginine and sildenafil citrate

omega-n-methylarginine has been researched along with sildenafil citrate in 6 studies

Compound Research Comparison

Studies (omega-n-methylarginine)	Trials (omega-n-methylarginine)	Recent Studies (post-2010) (omega-n-methylarginine)	Studies (sildenafil citrate)	Trials (sildenafil citrate)	Recent Studies (post-2010) (sildenafil citrate)
4,411	344	336	5,862	956	2,319

Protein Interaction Comparison

Protein	Taxonomy	omega-n-methylarginine (IC50)	sildenafil citrate (IC50)
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)		0.0036

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (83.33)	29.6817
2010's	1 (16.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Donahue, JK; Lawrence, JH; Marbán, E; Nagata, K	1
Chayama, K; Goto, C; Hara, K; Higashi, Y; Kimura, M; Nakagawa, K; Noma, K; Oshima, T; Sasaki, S; Yoshizumi, M	1
Daabees, TT; El-Metwally, MA; Senbel, AM; Sharabi, FM	1
Abraldes, JG; Groszmann, RJ; Haq, O; Iwakiri, Y; Loureiro-Silva, MR	1
Biaggioni, I; Christman, B; Diedrich, A; Farley, G; Gamboa, A; Paranjape, SY; Raj, SR; Robertson, D; Shibao, C	1
Curry, TB; Joyner, MJ; Kellawan, JM; Limberg, JK; Nicholson, WT; Schrage, WG; Scruggs, ZM	1

Trials

2 trial(s) available for omega-n-methylarginine and sildenafil citrate

Article	Year
PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers. Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:5 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Administration, Oral; Adult; Blood Pressure; Body Mass Index; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Endothelium; Enzyme Inhibitors; Forearm; Heart Rate; Humans; Infant; Male; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Piperazines; Purines; Regional Blood Flow; Sildenafil Citrate; Smoking; Sulfones; Vasodilation; Vasodilator Agents	2003
Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure. Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:6 Topics: Aged; Blood Pressure; Cross-Over Studies; Enzyme Inhibitors; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Piperazines; Purines; Shy-Drager Syndrome; Sildenafil Citrate; Sulfones; Supine Position; Vasodilator Agents	2008

Article

Year

PDE5 inhibitor sildenafil citrate augments endothelium-dependent vasodilation in smokers.

Hypertension (Dallas, Tex. : 1979), 2003, Volume: 41, Issue:5

Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Administration, Oral; Adult; Blood Pressure; Body Mass Index; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Endothelium; Enzyme Inhibitors; Forearm; Heart Rate; Humans; Infant; Male; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Piperazines; Purines; Regional Blood Flow; Sildenafil Citrate; Smoking; Sulfones; Vasodilation; Vasodilator Agents

2003

Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure.

Hypertension (Dallas, Tex. : 1979), 2008, Volume: 51, Issue:6

Topics: Aged; Blood Pressure; Cross-Over Studies; Enzyme Inhibitors; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Piperazines; Purines; Shy-Drager Syndrome; Sildenafil Citrate; Sulfones; Supine Position; Vasodilator Agents

2008

Other Studies

4 other study(ies) available for omega-n-methylarginine and sildenafil citrate

Article	Year
Phosphodiesterase inhibitor-mediated potentiation of adenovirus delivery to myocardium. Journal of molecular and cellular cardiology, 2001, Volume: 33, Issue:3 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Adenoviruses, Human; Animals; beta-Galactosidase; Cyclic GMP; Drug Synergism; Endothelial Growth Factors; Gene Transfer Techniques; Genes, Reporter; Genetic Vectors; Guanylate Cyclase; Heart; Humans; Isoquinolines; Lymphokines; Myocardium; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Piperazines; Purines; Purinones; Pyridines; Rabbits; Sildenafil Citrate; Sulfones; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2001
Effect of sildenafil on the isolated rat aortic rings. Fundamental & clinical pharmacology, 2005, Volume: 19, Issue:4 Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; In Vitro Techniques; Male; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones; Vasodilation	2005
Increased phosphodiesterase-5 expression is involved in the decreased vasodilator response to nitric oxide in cirrhotic rat livers. Journal of hepatology, 2006, Volume: 44, Issue:5 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Liver Circulation; Liver Cirrhosis; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasodilation	2006
Phosphodiesterase-5 inhibition preserves exercise-onset vasodilator kinetics when NOS activity is reduced. Journal of applied physiology (Bethesda, Md. : 1985), 2018, 02-01, Volume: 124, Issue:2 Topics: Adult; Cyclic GMP; Exercise; Female; Humans; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Phosphodiesterase 5 Inhibitors; Sildenafil Citrate; Vasodilation; Young Adult	2018