Page last updated: 2024-09-03

omega-n-methylarginine and phentolamine

omega-n-methylarginine has been researched along with phentolamine in 17 studies

Compound Research Comparison

Studies
(omega-n-methylarginine)
Trials
(omega-n-methylarginine)
Recent Studies (post-2010)
(omega-n-methylarginine)
Studies
(phentolamine)
Trials
(phentolamine)
Recent Studies (post-2010) (phentolamine)
4,4113443369,141270265

Protein Interaction Comparison

ProteinTaxonomyomega-n-methylarginine (IC50)phentolamine (IC50)
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.396
Alpha-2A adrenergic receptorHomo sapiens (human)0.006
Cytochrome P450 2D6Homo sapiens (human)10
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0316
Alpha-2B adrenergic receptorHomo sapiens (human)0.018
Alpha-2C adrenergic receptorHomo sapiens (human)0.11
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0492
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0492
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0492
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0316
Alpha-1D adrenergic receptorHomo sapiens (human)0.0173
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.359
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.396
Alpha-1A adrenergic receptorHomo sapiens (human)0.0011
Alpha-1B adrenergic receptorHomo sapiens (human)0.0108
5-hydroxytryptamine receptor 2BHomo sapiens (human)3.807
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0316
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.5495

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (35.29)18.2507
2000's7 (41.18)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Estrada, C; Fernandez, A; Gonzalez, C; Martin, C; Moncada, S1
Bayguinov, O; Sanders, KM1
Drexler, H; Heitzer, T; Just, H; Kurz, S; Luoma, J; Münzel, T; Olschewski, M; Ylä-Herttuala, S1
Dietz, NM; Engelke, KA; Fix, RT; Joyner, MJ; Samuel, TT1
Boegehold, MA; Linderman, JR1
Chavoshan, B; Sander, M; Victor, RG1
Halliwill, JR; Joyner, MJ; Minson, CT1
Emerson, GG; Segal, SS1
Ardilouze, JL; Currie, JM; Fielding, BA; Frayn, KN; Karpe, F1
Cornish, KG; Liu, XF; Patel, KP; Wang, Y; Zucker, IH1
Barbato, E; Bartunek, J; Chiariello, M; Cirillo, P; De Bruyne, B; De Luca, G; Galasso, G; Iaccarino, G; Piscione, F; Wijns, W1
Hayashi, K; Komine, H; Maeda, S; Miyauchi, T; Otsuki, T; Shimojo, N; Sugawara, J; Tanaka, H; Yokoi, T; Yoshizawa, M2
Green, DJ; Thijssen, DH1
Chowienczyk, P; Donald, A; Fok, H; Jiang, B; Seddon, M1
Alves, MJ; Brum, PC; dos Santos, MR; Martinez, DG; Middlekauff, HR; Nazaré Nunes Alves, MJ; Negrão, CE; Nobre, TS; Pereira Barretto, AC; Rondon, MU1
Carrithers, JA; Gavin, TP; Hickner, RC; Kraus, RM; La Favor, JD; Roseno, SL1

Trials

5 trial(s) available for omega-n-methylarginine and phentolamine

ArticleYear
Evidence for nitric oxide-mediated sympathetic forearm vasodiolatation in humans.
    The Journal of physiology, 1997, Jan-15, Volume: 498 ( Pt 2)

    Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Adult; Bretylium Tosylate; Enzyme Inhibitors; Exercise; Female; Forearm; Hemodynamics; Humans; Ischemia; Male; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Phentolamine; Regional Blood Flow; Sympathectomy, Chemical; Sympathetic Nervous System; Vasodilation

1997
Effect of systemic nitric oxide synthase inhibition on postexercise hypotension in humans.
    Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:5

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Cardiac Output; Cold Temperature; Enzyme Inhibitors; Female; Heart Rate; Humans; Hypotension; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phentolamine; Physical Exertion; Sympathetic Nervous System; Vascular Resistance

2000
Systemic alpha-adrenergic and nitric oxide inhibition on basal limb blood flow: effects of endurance training in middle-aged and older adults.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:3

    Topics: Adrenergic alpha-Antagonists; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Exercise; Female; Femoral Artery; Humans; Leg; Male; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Phentolamine; Physical Endurance; Receptors, Adrenergic, alpha; Regional Blood Flow; Sympathetic Nervous System; Vasoconstriction

2007
Effect of systemic nitric oxide synthase inhibition on arterial stiffness in humans.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2007, Volume: 30, Issue:5

    Topics: Adrenergic alpha-Antagonists; Aorta; Blood Pressure; Carotid Arteries; Elasticity; Enzyme Inhibitors; Female; Heart Rate; Humans; Male; Middle Aged; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Phentolamine; Pulsatile Flow; Sympathetic Nervous System

2007
Flow-mediated dilation of the radial artery is offset by flow-induced reduction in transmural pressure.
    Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:6

    Topics: Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Blood Pressure; Brachial Artery; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hyperemia; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phentolamine; Radial Artery; Vasodilation; Young Adult

2011

Other Studies

12 other study(ies) available for omega-n-methylarginine and phentolamine

ArticleYear
Nitric oxide from endothelium and smooth muscle modulates responses to sympathetic nerve stimulation: implications for endotoxin shock.
    Biochemical and biophysical research communications, 1992, Jul-15, Volume: 186, Issue:1

    Topics: Acetylcholine; Animals; Arginine; Cycloheximide; Dexamethasone; Dinoprost; Endothelium, Vascular; Endotoxins; Iliac Artery; In Vitro Techniques; Interferon-gamma; Isometric Contraction; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Phentolamine; Prazosin; Rats; Rats, Inbred Strains; Shock, Septic

1992
Role of nitric oxide as an inhibitory neurotransmitter in the canine pyloric sphincter.
    The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 1

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Arginine; Cyclic GMP; Dogs; Duodenum; Electric Stimulation; Female; Gastric Mucosa; In Vitro Techniques; Intercellular Junctions; Intestinal Mucosa; Male; Membrane Potentials; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Oxyhemoglobins; Phentolamine; Propranolol; Purinones; Pylorus; Stomach; Tetrodotoxin

1993
Cigarette smoking potentiates endothelial dysfunction of forearm resistance vessels in patients with hypercholesterolemia. Role of oxidized LDL.
    Circulation, 1996, Apr-01, Volume: 93, Issue:7

    Topics: Acetylcholine; Adrenergic alpha-Antagonists; Arginine; Arteriosclerosis; Autoantibodies; Cardiovascular Diseases; Endothelium, Vascular; Female; Forearm; Humans; Hypercholesterolemia; Lipid Peroxidation; Lipoproteins, LDL; Male; Middle Aged; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Oxidation-Reduction; Phentolamine; Risk Factors; Smoking; Vascular Resistance; Vasodilation; Vasodilator Agents; Vasomotor System

1996
Modulation of arteriolar sympathetic constriction by local nitric oxide: onset during rapid juvenile growth.
    Microvascular research, 1998, Volume: 56, Issue:3

    Topics: Aging; Animals; Arterioles; Electric Stimulation; Enzyme Inhibitors; Male; Muscle, Skeletal; Nitric Oxide; omega-N-Methylarginine; Phentolamine; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Tetrodotoxin; Vasoconstriction

1998
A large blood pressure-raising effect of nitric oxide synthase inhibition in humans.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 33, Issue:4

    Topics: Adult; Blood Pressure; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phentolamine

1999
Electrical activation of endothelium evokes vasodilation and hyperpolarization along hamster feed arteries.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:1

    Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Cricetinae; Electric Stimulation; Electrophysiology; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Mesocricetus; Microelectrodes; Muscle, Skeletal; omega-Conotoxins; omega-N-Methylarginine; Phentolamine; Tetrodotoxin; Vascular Resistance; Vasodilation

2001
Nitric oxide and beta-adrenergic stimulation are major regulators of preprandial and postprandial subcutaneous adipose tissue blood flow in humans.
    Circulation, 2004, Jan-06, Volume: 109, Issue:1

    Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Eating; Female; Glucose; Humans; Infusions, Parenteral; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phentolamine; Propranolol; Receptors, Adrenergic, beta; Regional Blood Flow; Xenon Radioisotopes; Yohimbine

2004
Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 288, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Blood Pressure; Blotting, Northern; Cardiac Output, Low; Chronic Disease; Heart Rate; Hemodynamics; Immunohistochemistry; Male; Metoprolol; Microinjections; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oligonucleotides, Antisense; omega-N-Methylarginine; Paraventricular Hypothalamic Nucleus; Phentolamine; Rats; Rats, Sprague-Dawley

2005
Role of beta2 adrenergic receptors in human atherosclerotic coronary arteries.
    Circulation, 2005, Jan-25, Volume: 111, Issue:3

    Topics: Acetylcholine; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Albuterol; Constriction, Pathologic; Coronary Angiography; Coronary Artery Disease; Coronary Vessels; Endothelium, Vascular; Female; Hemodynamics; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nitric Oxide Synthase; Nitro Compounds; omega-N-Methylarginine; Phentolamine; Receptors, Adrenergic, beta-2; Vasoconstrictor Agents; Vasodilator Agents

2005
De Motu Arteriarum: hemodynamics and arterial function in humans.
    Hypertension (Dallas, Tex. : 1979), 2011, Volume: 57, Issue:6

    Topics: Adrenergic alpha-Antagonists; Blood Pressure; Brachial Artery; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hyperemia; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phentolamine; Radial Artery; Vasodilation

2011
Mechanisms of blunted muscle vasodilation during peripheral chemoreceptor stimulation in heart failure patients.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:3

    Topics: Adult; Ascorbic Acid; Case-Control Studies; Chemoreceptor Cells; Forearm; Heart Failure; Hemodynamics; Humans; Hypoxia; Middle Aged; Muscle, Smooth, Vascular; omega-N-Methylarginine; Oxidative Stress; Phentolamine; Regional Blood Flow; Sympathetic Nervous System; Vasoconstriction; Vasodilation

2012
Sex differences with aging in nutritive skeletal muscle blood flow: impact of exercise training, nitric oxide, and α-adrenergic-mediated mechanisms.
    American journal of physiology. Heart and circulatory physiology, 2014, Aug-15, Volume: 307, Issue:4

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aging; Enzyme Inhibitors; Exercise; Female; Humans; Male; Middle Aged; Muscle, Skeletal; Nitric Oxide Donors; Nitroprusside; Norepinephrine; omega-N-Methylarginine; Phentolamine; Regional Blood Flow; Sex Factors; Vasoconstriction; Vasodilator Agents

2014