Page last updated: 2024-09-03

omega-n-methylarginine and nifedipine

omega-n-methylarginine has been researched along with nifedipine in 14 studies

Compound Research Comparison

Studies
(omega-n-methylarginine)
Trials
(omega-n-methylarginine)
Recent Studies (post-2010)
(omega-n-methylarginine)
Studies
(nifedipine)
Trials
(nifedipine)
Recent Studies (post-2010) (nifedipine)
4,41134433616,0242,4961,505

Protein Interaction Comparison

ProteinTaxonomyomega-n-methylarginine (IC50)nifedipine (IC50)
perilipin-5Homo sapiens (human)7.133
perilipin-1Homo sapiens (human)9.619
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform aHomo sapiens (human)8.376
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.0429
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.035
Cytochrome P450 1A2Homo sapiens (human)0.3
Cytochrome P450 3A4Homo sapiens (human)10
Adenosine receptor A3Homo sapiens (human)7.214
Cytochrome P450 2C9 Homo sapiens (human)3.06
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)10
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)7.214
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)0.0385
Potassium voltage-gated channel subfamily A member 5Homo sapiens (human)6.1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Rattus norvegicus (Norway rat)1.12
Adenosine receptor A1Homo sapiens (human)7.701
3-oxo-5-alpha-steroid 4-dehydrogenase 2Rattus norvegicus (Norway rat)1.12
C-C chemokine receptor type 2Homo sapiens (human)2.191
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)7.214
Cytochrome P450 2J2Homo sapiens (human)3.06
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.4733
Voltage-dependent L-type calcium channel subunit alpha-1CMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.035
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.0394
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.02
Potassium channel subfamily K member 2 Bos taurus (cattle)8.2
Indoleamine 2,3-dioxygenase 2Mus musculus (house mouse)1.5
Voltage-dependent L-type calcium channel subunit alpha-1DMus musculus (house mouse)1.2
Voltage-dependent L-type calcium channel subunit alpha-1FMus musculus (house mouse)1.2

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (57.14)18.2507
2000's5 (35.71)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mizusawa, H; Omote, M1
Cocks, TM; Kilpatrick, EV1
Gross, SS; Mitchell, JA; Szabó, C; Thiemermann, C; Vane, JR1
Chaturvedi, UC; Misra, A; Mukerjee, R1
Boer, P; Dijkhorst-Oei, LT; Koomans, HA; Rabelink, TJ1
Choate, JK; Paterson, DJ; Sears, CE1
Beutler, JJ; Dijkhorst-Oei, LT; Koomans, HA; Rabelink, TJ; Stroes, ES1
Milstone, DS; Mortensen, RM; Sowell, MO; Vassilev, PM; Ye, C1
Favilla, S; Ghiadoni, L; Magagna, A; Pompella, A; Salvetti, A; Taddei, S; Virdis, A1
Karlsson, JO; Lossius, K; Persson, AA; Støen, R1
Arakawa, N; Hiramori, K; Nagano, M; Naganuma, Y; Nakamura, M; Yoshida, H1
Chuan, P; Domenech, C; Lluch, S; Medina, P; Segarra, G; Vila, JM1
Fukuo, K; Kaimoto, T; Ogihara, T; Sato, N; Suhara, T; Suzuki, T; Takemura, Y; Yang, J; Yasuda, O1
Hälinen, M; Haverinen, J; Vornanen, M1

Trials

2 trial(s) available for omega-n-methylarginine and nifedipine

ArticleYear
Divergent effects of ACE-inhibition and calcium channel blockade on NO-activity in systemic and renal circulation in essential hypertension.
    Cardiovascular research, 1998, Volume: 40, Issue:2

    Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Cardiac Output; Dose-Response Relationship, Drug; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Renal Circulation; Vascular Resistance

1998
Nitric oxide plays an insignificant role in direct vasodilator effects of calcium channel blockers in healthy humans.
    Heart and vessels, 2002, Volume: 16, Issue:3

    Topics: Adult; Blood Pressure; Calcium Channel Blockers; Diltiazem; Endothelium, Vascular; Enzyme Inhibitors; Forearm; Heart Rate; Humans; Male; Nicardipine; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Plethysmography; Vasodilation; Vasodilator Agents

2002

Other Studies

12 other study(ies) available for omega-n-methylarginine and nifedipine

ArticleYear
Phenylephrine-induced rhythmic activity in the rabbit ear artery.
    The Japanese journal of physiology, 1993, Volume: 43, Issue:4

    Topics: Animals; Arginine; Arteries; Charybdotoxin; Ear, External; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Male; Nifedipine; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Periodicity; Phenylephrine; Potassium Channel Blockers; Prostaglandin Antagonists; Rabbits; Scorpion Venoms; Vasoconstriction

1993
Evidence for differential roles of nitric oxide (NO) and hyperpolarization in endothelium-dependent relaxation of pig isolated coronary artery.
    British journal of pharmacology, 1994, Volume: 112, Issue:2

    Topics: Animals; Arginine; Coronary Vessels; Endothelium, Vascular; Female; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Potassium; Substance P; Swine

1994
Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 265, Issue:2

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Line; Cycloheximide; Dexamethasone; Enzyme Induction; Hemodynamics; Lipopolysaccharides; Lung; Macrophages; Male; Mice; Muscle, Smooth; Nifedipine; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Rats; Rats, Wistar

1993
Production of nitrite by dengue virus-induced cytotoxic factor.
    Clinical and experimental immunology, 1996, Volume: 104, Issue:3

    Topics: Animals; Antibodies, Blocking; B-Lymphocytes; Biological Assay; Calcium; Cells, Cultured; Culture Media; Cytokines; Dengue; Dose-Response Relationship, Drug; Macrophages; Mice; Nifedipine; Nitrites; omega-N-Methylarginine; Spleen; T-Lymphocytes

1996
Nifedipine attenuates systemic and renal vasoconstriction during nitric oxide inhibition in humans.
    Hypertension (Dallas, Tex. : 1979), 1997, Volume: 29, Issue:5

    Topics: Adult; Blood Pressure; Calcium Channel Blockers; Drug Interactions; Enzyme Inhibitors; Hemodynamics; Humans; Infusions, Intravenous; Male; Nifedipine; Nitric Oxide; omega-N-Methylarginine; Renal Circulation; Vasoconstriction

1997
Inhibition of nitric oxide synthase slows heart rate recovery from cholinergic activation.
    Journal of applied physiology (Bethesda, Md. : 1985), 1998, Volume: 84, Issue:5

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Arginine; Calcium Channel Blockers; Cardiovascular Agents; Cesium; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Heart Rate; Male; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Pyrimidines; Vagus Nerve

1998
Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes.
    Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:9

    Topics: Action Potentials; Animals; Calcium Channels; Calcium Channels, L-Type; Carbachol; Cell Line; GTP-Binding Proteins; Heart; Heart Ventricles; Isoproterenol; Mice; Models, Cardiovascular; Molsidomine; Muscarinic Antagonists; Myocardium; Nifedipine; Nitric Oxide Donors; omega-N-Methylarginine; Pertussis Toxin; Receptors, Muscarinic; Stem Cells; Virulence Factors, Bordetella

1999
Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:3

    Topics: Acetylcholine; Antioxidants; Ascorbic Acid; Blood Pressure; Calcium Channel Blockers; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidative Stress; Regional Blood Flow; Time Factors; Vasodilation

2001
Relative significance of the nitric oxide (NO)/cGMP pathway and K+ channel activation in endothelium-dependent vasodilation in the femoral artery of developing piglets.
    Acta physiologica Scandinavica, 2001, Volume: 171, Issue:1

    Topics: Acetylcholine; Animals; Animals, Newborn; Calcium Channel Blockers; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Femoral Artery; Male; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Potassium; Potassium Channels; Swine; Vasodilation; Vasodilator Agents

2001
Increased contraction to noradrenaline by vasopressin in human renal arteries.
    Journal of hypertension, 2002, Volume: 20, Issue:7

    Topics: Aged; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Nifedipine; Norepinephrine; omega-N-Methylarginine; Potassium Chloride; Renal Artery; Vasoconstriction; Vasoconstrictor Agents

2002
Nifedipine upregulates manganese superoxide dismutase expression in vascular smooth muscle cells via endothelial cell-dependent pathways.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2003, Volume: 26, Issue:6

    Topics: Blotting, Western; Calcium Channel Blockers; Cell Division; Cells, Cultured; Coculture Techniques; Endothelial Cells; Enzyme Inhibitors; Humans; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oligonucleotides, Antisense; omega-N-Methylarginine; Superoxide Dismutase; Tubulin; Up-Regulation

2003
Sinoatrial tissue of crucian carp heart has only negative contractile responses to autonomic agonists.
    BMC physiology, 2010, Jun-11, Volume: 10

    Topics: Acclimatization; Action Potentials; Animals; Calcium Channels; Calcium Channels, L-Type; Carbachol; Carps; Cholinergic Agonists; Cold Temperature; Enzyme Inhibitors; Heart Rate; Hot Temperature; Hypoxia; Isoproterenol; Myocardial Contraction; Nifedipine; Nitric Oxide Synthase; omega-N-Methylarginine; Parasympathetic Nervous System; Potassium Channels; Seasons; Sinoatrial Node; Species Specificity; Sympathetic Nervous System

2010