Page last updated: 2024-09-03

omega-n-methylarginine and lysine

omega-n-methylarginine has been researched along with lysine in 36 studies

Compound Research Comparison

Studies (omega-n-methylarginine)	Trials (omega-n-methylarginine)	Recent Studies (post-2010) (omega-n-methylarginine)	Studies (lysine)	Trials (lysine)	Recent Studies (post-2010) (lysine)
4,411	344	336	37,449	622	11,213

Protein Interaction Comparison

Protein	Taxonomy	omega-n-methylarginine (IC50)	lysine (IC50)
Cationic amino acid transporter 3	Homo sapiens (human)		158

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	13 (36.11)	18.2507
2000's	20 (55.56)	29.6817
2010's	3 (8.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fast, W; Hong, L	1
Lazarides, E; Lin, JM; Wang, C	1
Akabane, S; Ashida, T; Imanishi, M; Kawamura, M; Kawano, Y; Kinoshita, O; Kuramochi, M; Matsushima, Y; Yoshida, K; Yoshimi, H	1
Bernier, M; Egan, JM; Henderson, TE	1
Abe, Y; Aki, Y; Kimura, S; Takenaka, I; Tamaki, T; Yoshida, H	1
Bruni, P; Farnararo, M; Meacci, E; Vasta, V	1
Bogdan, C; Manning, P; Rollinghoff, M; Stenger, S; Thuring, H	1
Angelo, S; Boyd, CA; Devés, R; Forray, MI	1
Acampora, R; Coppola, L; D'Onofrio, F; Giugliano, D; Giunta, R; Lucarelli, C; Marfella, R; Nappo, F; Verrazzo, G	1
Binion, DG; Chai, YC; Drazba, JA; Dweik, RA; Erzurum, SC; Fu, S; Ramanujam, KS; Wade, JG; Wilson, KT; Ziats, NP	1
Albrecht, J; Dolińska, M	1
McMurtry, IF; Rodman, DM; Sato, K	1
Giraldo-Velásquez, M; Gross, U; Lüder, CG; Sendtner, M	1
Casadei, B; Musialek, P; Paterson, DJ	1
Frank, S; Kämpfer, H; Pfeilschifter, J; Stallmeyer, B; Wetzler, C	1
Casado, FJ; Celada, A; Felipe, A; Pastor-Anglada, M; Soler, C	1
Busato, A; Jungi, T; Lang, J; Pfister, H; Schawalder, P; Sigrist, N; Spreng, D	1
Cholewa, B; Mattson, DL; Wu, F	1
Hucks, D; Ward, JP	1
McCartney-Francis, NL; Mizel, DE; Song , X; Wahl, SM	1
Beach, PK; Garrison, RN; Harris, PD; Kawabe, T; Spain, DA	1
Boyd, CA; Cuffe, JE; Howard, DP; Korbmacher, C	1
Guo, Q; Packer, L; Rimbach, G	1
Connor, J; Farrelly, LW; Gilkeson, GS; Hutchison, F; Manning, P; Redmond, ST; Reilly, CM; Ruiz, P; Viti, D	1
Bucci, TJ; Hinson, JA; Irwin, LK; Mayeux, PR; Michael, SL	1
Deitch, EA; Forsythe, RM; Lu, Q; Xu, DZ	1
Gattuso, A; Imbrogno, S; Mazza, R; Nylund, A; Sverdrup, A; Tota, B	1
Bussolati, O; Dall'Asta, V; Gazzola, GC; Rotoli, BM; Sala, R	1
Espana, EM; He, H; Kawakita, T; Li, W; Tseng, SC	1
Njoku, CJ; Oates, JC; Patrick, KS; Ruiz, P	1
Costello, AL; Fast, W; Stone, EM; Tierney, DL	1
Kondapaneni, M; Laubach, VE; McGregor, JR; Salvemini, D; Samlowski, WE	1
Brennan, DM; Cho, L; Hazen, SL; Tang, WH; Wang, Z	1
Móricz, AM; Ott, PG; Otta, KH; Tyihák, E	1
Choe, J; Ha, KS; Jeoung, D; Kim, YM; Kwon, YG; Lee, DK; Lee, H; Lee, KS; Won, MH	1
Clish, CB; Coresh, J; Fox, CS; Gerszten, RE; Hwang, SJ; Larson, MG; Levy, D; Li, M; McMahon, GM; O'Donnell, CJ; Rhee, EP; Tin, A; Yang, Q; Young, JH	1

Other Studies

36 other study(ies) available for omega-n-methylarginine and lysine

Article	Year
Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia. The Journal of biological chemistry, 2007, Nov-30, Volume: 282, Issue:48 Topics: Amidohydrolases; Amino Acid Sequence; Animals; Binding Sites; Cloning, Molecular; Cysteine; Dose-Response Relationship, Drug; Drug Design; Homocysteine; Humans; Hydrogen Peroxide; Hyperhomocysteinemia; Kinetics; Molecular Sequence Data; Oxidation-Reduction; Sequence Homology, Amino Acid; Substrate Specificity	2007
Methylations of 70,000-Da heat shock proteins in 3T3 cells: alterations by arsenite treatment, by different stages of growth and by virus transformation. Archives of biochemistry and biophysics, 1992, Aug-15, Volume: 297, Issue:1 Topics: 3T3 Cells; Animals; Arginine; Arsenic; Arsenites; Avian Sarcoma Viruses; Cell Division; Cell Transformation, Viral; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Lysine; Methionine; Methylation; Mice; Molecular Weight; omega-N-Methylarginine	1992
Differential effects of endothelin-1 and big endothelin on canine kidneys. Journal of cardiovascular pharmacology, 1991, Volume: 17 Suppl 7 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Aspirin; Dogs; Endothelin-1; Endothelins; Female; Infusions, Intra-Arterial; Kidney; Lysine; Male; Nitric Oxide; omega-N-Methylarginine; Prostaglandins; Protein Precursors; Renal Circulation	1991
Arginine enhances glycogen synthesis in response to insulin in 3T3-L1 adipocytes. The American journal of physiology, 1995, Volume: 269, Issue:1 Pt 1 Topics: 3T3 Cells; Adenosine Triphosphate; Adipocytes; Animals; Arginine; Biological Transport; Cell Line; Glucose; Glutamic Acid; Glycogen; Insulin; Lysine; Mice; Nitric Oxide; omega-N-Methylarginine	1995
Effects of angiotensin II on isolated rabbit afferent arterioles. Japanese journal of pharmacology, 1994, Volume: 66, Issue:4 Topics: Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Arterioles; Aspirin; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Lysine; Male; Nitric Oxide; omega-N-Methylarginine; Prostaglandin Antagonists; Prostaglandins; Rabbits; Renal Circulation; Tetrazoles; Vascular Resistance	1994
Identification of a specific transport system for L-arginine in human platelets. Biochemical and biophysical research communications, 1995, Jan-26, Volume: 206, Issue:3 Topics: Arginine; Biological Transport; Blood Platelets; Carrier Proteins; Humans; Kinetics; Lysine; Nitric Oxide; omega-N-Methylarginine; Ornithine; Sodium	1995
L-N6-(1-iminoethyl)-lysine potently inhibits inducible nitric oxide synthase and is superior to NG-monomethyl-arginine in vitro and in vivo. European journal of pharmacology, 1995, Dec-29, Volume: 294, Issue:2-3 Topics: Animals; Arginine; Cells, Cultured; Enzyme Inhibitors; Female; Leishmaniasis; Lysine; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; omega-N-Methylarginine	1995
Transport of nitric oxide synthase inhibitors through cationic amino acid carriers in human erythrocytes. Biochemical pharmacology, 1995, Dec-22, Volume: 50, Issue:12 Topics: Arginine; Biological Transport; Cations; Erythrocytes; Ethylmaleimide; Humans; Kinetics; Lysine; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine	1995
Vascular effects of acute hyperglycemia in humans are reversed by L-arginine. Evidence for reduced availability of nitric oxide during hyperglycemia. Circulation, 1997, Apr-01, Volume: 95, Issue:7 Topics: Acute Disease; Adult; Arginine; Blood Viscosity; Catecholamines; Female; Free Radicals; Glucose; Glutathione; Hemodynamics; Humans; Hyperglycemia; Insulin; Lysine; Male; Nitric Oxide; omega-N-Methylarginine; Platelet Aggregation; Vasoconstriction	1997
iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. The American journal of physiology, 1998, Volume: 275, Issue:3 Topics: Arginine; Cell Adhesion; Cells, Cultured; DNA Primers; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Intestinal Mucosa; Leukocytes; Lipopolysaccharides; Lysine; Microcirculation; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Polymerase Chain Reaction; Tumor Necrosis Factor-alpha; Umbilical Veins	1998
L-arginine uptake in rat cerebral mitochondria. Neurochemistry international, 1998, Volume: 33, Issue:3 Topics: Animals; Arginine; Biological Transport; Brain; Carbon Radioisotopes; Enzyme Inhibitors; Female; Kinetics; Lysine; Mitochondria; Nitric Oxide Synthase; omega-N-Methylarginine; Ornithine; Rats; Rats, Wistar	1998
Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs. The American journal of physiology, 1999, Volume: 276, Issue:4 Topics: Animals; Arginine; Biopterins; Egtazic Acid; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Luminescent Measurements; Lung; Lysine; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; Time Factors	1999
Toxoplasma gondii in primary rat CNS cells: differential contribution of neurons, astrocytes, and microglial cells for the intracerebral development and stage differentiation. Experimental parasitology, 1999, Volume: 93, Issue:1 Topics: Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Interferon-gamma; Lysine; Male; Microglia; Microscopy, Confocal; Neurons; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Wistar; Toxoplasma; Toxoplasmosis, Animal; Toxoplasmosis, Cerebral; Vacuoles	1999
Changes in extracellular pH mediate the chronotropic responses to L-arginine. Cardiovascular research, 1999, Aug-15, Volume: 43, Issue:3 Topics: Analysis of Variance; Animals; Arginine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Extracellular Space; Guinea Pigs; Heart Rate; Hydrogen-Ion Concentration; Isomerism; Lysine; Nitric Oxide Synthase; omega-N-Methylarginine; Perfusion; Stimulation, Chemical	1999
Large induction of the chemotactic cytokine RANTES during cutaneous wound repair: a regulatory role for nitric oxide in keratinocyte-derived RANTES expression. The Biochemical journal, 2000, Apr-01, Volume: 347 Pt 1 Topics: Animals; Cell Line; Chemokine CCL5; Female; Gene Expression Regulation; Humans; Keratinocytes; Lysine; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Skin; Time Factors; Transcription, Genetic; Wound Healing; Wounds and Injuries	2000
Nitric oxide regulates nucleoside transport in activated B lymphocytes. Journal of leukocyte biology, 2000, Volume: 67, Issue:3 Topics: Arginine; B-Lymphocytes; Biological Transport; Carrier Proteins; Equilibrative Nucleoside Transporter 1; Gene Expression Regulation; Humans; Lymphocyte Activation; Lysine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroso Compounds; Nucleoside Transport Proteins; Nucleosides; omega-N-Methylarginine; RNA, Messenger; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha	2000
Nitric oxide metabolite production in the cranial cruciate ligament, synovial membrane, and articular cartilage of dogs with cranial cruciate ligament rupture. American journal of veterinary research, 2000, Volume: 61, Issue:5 Topics: Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Cartilage, Articular; Dog Diseases; Dogs; Female; Lysine; Male; Nitrates; Nitric Oxide; Nitrites; omega-N-Methylarginine; Osteoarthritis; Rupture; Statistics, Nonparametric; Synovial Membrane	2000
Characterization of L-arginine transporters in rat renal inner medullary collecting duct. American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 278, Issue:6 Topics: Amino Acid Transport Systems; Animals; Arginine; beta-Alanine; Biological Transport; Carrier Proteins; Cations; Citrulline; Enzyme Inhibitors; Gene Expression; Homeostasis; Kidney Medulla; Kidney Tubules, Collecting; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Ornithine; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substrate Specificity; Tritium; Water-Electrolyte Balance	2000
Critical dependence of the NO-mediated component of cyclic AMP-induced vasorelaxation on extracellular L-arginine in pulmonary arteries of the rat. British journal of pharmacology, 2000, Volume: 130, Issue:5 Topics: Animals; Arginine; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isoproterenol; Lysine; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Pulmonary Artery; Rats; Rats, Wistar; Vasodilation	2000
Selective inhibition of inducible nitric oxide synthase exacerbates erosive joint disease. Journal of immunology (Baltimore, Md. : 1950), 2001, Feb-15, Volume: 166, Issue:4 Topics: Administration, Oral; Animals; Arthritis, Experimental; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Hindlimb; Injections, Intraperitoneal; Isoenzymes; Leukocytes, Mononuclear; Leukocytosis; Lysine; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Polysaccharides, Bacterial; Rats; Rats, Inbred Lew	2001
Sepsis increases NOS-2 activity and decreases non-NOS-mediated acetylcholine-induced dilation in rat aorta. The Journal of surgical research, 2001, Volume: 96, Issue:1 Topics: Acetylcholine; Animals; Aorta; Enzyme Inhibitors; In Vitro Techniques; Lysine; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Sepsis; Vasodilation; Vasodilator Agents	2001
L-arginine effects on Na+ transport in M-1 mouse cortical collecting duct cells--a cationic amino acid absorbing epithelium. The Journal of membrane biology, 2001, Mar-15, Volume: 180, Issue:2 Topics: Amiloride; Animals; Arginine; Cell Line; Cell Polarity; Diuretics; Electrophysiology; Enzyme Inhibitors; Epithelial Cells; Histidine; Ion Transport; Kidney Tubules, Collecting; Lysine; Mice; omega-N-Methylarginine; Penicillamine; S-Nitroso-N-Acetylpenicillamine; Sodium; Urothelium	2001
Nitric oxide formation in macrophages detected by spin trapping with iron-dithiocarbamate complex: effect of purified flavonoids and plant extracts. Methods in enzymology, 2001, Volume: 335 Topics: Animals; Arginine; Cell Line; Ferrous Compounds; Flavonoids; Kinetics; Lysine; Macrophages; Mice; Nitric Oxide; omega-N-Methylarginine; Plant Extracts; Spin Labels; Superoxide Dismutase; Thiocarbamates	2001
Modulation of renal disease in MRL/lpr mice by pharmacologic inhibition of inducible nitric oxide synthase. Kidney international, 2002, Volume: 61, Issue:3 Topics: Animals; Enzyme Inhibitors; Kidney; Kidney Diseases; Lysine; Mice; Mice, Inbred MRL lpr; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Proteinuria	2002
Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice. Nitric oxide : biology and chemistry, 2002, Volume: 6, Issue:2 Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Drug Interactions; Enzyme Inhibitors; Guanidines; Liver; Lysine; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine	2002
Lipopolysaccharide-induced enterocyte-derived nitric oxide induces intestinal monolayer permeability in an autocrine fashion. Shock (Augusta, Ga.), 2002, Volume: 17, Issue:3 Topics: Animals; Bacterial Translocation; Cell Membrane Permeability; Cells, Cultured; Coumarins; Enterocytes; Enzyme Inhibitors; Intestines; Lipopolysaccharides; Lysine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Permeability; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; S-Nitroso-N-Acetylpenicillamine	2002
Cardiac performance in Salmo salar with infectious salmon anaemia (ISA): putative role of nitric oxide. Diseases of aquatic organisms, 2002, Nov-07, Volume: 52, Issue:1 Topics: Animals; Arginine; Enzyme Induction; Enzyme Inhibitors; Fish Diseases; Heart; Lysine; Myocardial Contraction; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Orthomyxoviridae; Orthomyxoviridae Infections; Salmo salar	2002
The transport of cationic amino acids in human airway cells: expression of system y+L activity and transepithelial delivery of NOS inhibitors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:7 Topics: Adenocarcinoma; Amino Acid Transport System y+L; Amino Acids; Animals; Arginine; Biological Transport; Cations; Cell Line; Cell Line, Tumor; Cell Membrane Permeability; Culture Media, Conditioned; Epithelial Cells; Gene Expression; Humans; Lung Neoplasms; Lysine; Macrophages; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; omega-N-Methylarginine; Respiratory System; Reverse Transcriptase Polymerase Chain Reaction	2005
Amniotic membrane induces apoptosis of interferon-gamma activated macrophages in vitro. Experimental eye research, 2006, Volume: 82, Issue:2 Topics: Amnion; Animals; Apoptosis; Blotting, Western; Cell Culture Techniques; Cell Death; Collagen Type I; Culture Media, Conditioned; eIF-2 Kinase; I-kappa B Kinase; Interferon-gamma; Lysine; Macrophage Activation; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Oncogene Protein v-akt; Time Factors; Tumor Necrosis Factor-alpha	2006
Inducible nitric oxide synthase inhibitors reduce urinary markers of systemic oxidant stress in murine proliferative lupus nephritis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2005, Volume: 53, Issue:7 Topics: Animals; Biomarkers; Dinoprost; Enzyme Inhibitors; Female; Lupus Nephritis; Lysine; Mice; Mice, Inbred NZB; Nitrates; Nitric Oxide Synthase Type II; Nitrites; omega-N-Methylarginine; Oxidative Stress	2005
Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa. Biochemistry, 2006, May-02, Volume: 45, Issue:17 Topics: Amidohydrolases; Binding Sites; Citrulline; Cobalt; Cysteine; Hydrogen-Ion Concentration; Iodoacetamide; Kinetics; Lysine; Mass Spectrometry; Models, Chemical; omega-N-Methylarginine; Protons; Pseudomonas aeruginosa; Spectrophotometry, Ultraviolet; Spectrum Analysis; Thiourea; X-Rays; Zinc	2006
Inducible nitric oxide synthase (iNOS) is not required for IL-2-induced hypotension and vascular leak syndrome in mice. Journal of immunotherapy (Hagerstown, Md. : 1997), 2008, Volume: 31, Issue:4 Topics: Animals; Capillary Leak Syndrome; Capillary Permeability; Genetic Predisposition to Disease; Hypotension; Interferon-gamma; Interleukin-2; Lysine; Manganese; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Organometallic Compounds	2008
Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition. Arteriosclerosis, thrombosis, and vascular biology, 2009, Volume: 29, Issue:9 Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Citrulline; Coronary Artery Disease; Creatinine; Female; Humans; Lysine; Male; Metabolomics; Methylation; Middle Aged; Nitric Oxide Synthase; Odds Ratio; omega-N-Methylarginine; Ornithine; Prognosis; Prospective Studies; Protein Processing, Post-Translational; Risk Assessment; Risk Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors	2009
Investigation of the antibacterial mechanism of aflatoxins in the BioArena system. Natural product communications, 2011, Volume: 6, Issue:5 Topics: Aflatoxins; Cyclohexenes; Formaldehyde; Indigo Carmine; Limonene; Lysine; omega-N-Methylarginine; Ozone; Pseudomonas; Terpenes	2011
Differential effects of substrate-analogue inhibitors on nitric oxide synthase dimerization. Biochemical and biophysical research communications, 2012, Feb-03, Volume: 418, Issue:1 Topics: Animals; Cell Line; Enzyme Inhibitors; Guanidines; Lysine; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; omega-N-Methylarginine; Ornithine; Protein Multimerization; Substrate Specificity	2012
Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease. Kidney international, 2017, Volume: 91, Issue:6 Topics: Aged; Amino Acid Transport Systems, Basic; Amino Acids; Biomarkers; Case-Control Studies; Chi-Square Distribution; Female; Genetic Predisposition to Disease; Glycine; Histidine; Humans; Incidence; Logistic Models; Lysine; Male; Mass Spectrometry; Massachusetts; Metabolomics; Middle Aged; Odds Ratio; Oligonucleotide Array Sequence Analysis; omega-N-Methylarginine; Phenotype; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prospective Studies; Protective Factors; Renal Insufficiency, Chronic; Risk Assessment; Risk Factors; Urinalysis	2017