Page last updated: 2024-09-03

omega-n-methylarginine and bq 123

omega-n-methylarginine has been researched along with bq 123 in 33 studies

Compound Research Comparison

Studies (omega-n-methylarginine)	Trials (omega-n-methylarginine)	Recent Studies (post-2010) (omega-n-methylarginine)	Studies (bq 123)	Trials (bq 123)	Recent Studies (post-2010) (bq 123)
4,411	344	336	1,391	63	152

Protein Interaction Comparison

Protein	Taxonomy	omega-n-methylarginine (IC50)	bq 123 (IC50)
Endothelin-1 receptor	Homo sapiens (human)		0.017
Endothelin-1 receptor	Rattus norvegicus (Norway rat)		0.014

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	20 (60.61)	18.2507
2000's	11 (33.33)	29.6817
2010's	2 (6.06)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hori, M; Karaki, H; Sudjarwo, SA	1
Fujitani, Y; Karaki, H; Okada, T; Ueda, H; Urade, Y	1
Marumo, F; Nonoguchi, H; Owada, A; Sakamoto, H; Terada, Y; Tomita, K	1
Fukuuchi, Y; Kobari, M; Konno, S; Takeda, H; Tanahashi, N; Tomita, M	2
Riezebos, J; Vallance, PJ; Watts, IS	1
Bodelsson, G; Stjernquist, M	1
Hayashi, H; Katori, M; Majima, M; Ohno, T; Saigenji, K	1
Coessens, BC; Miller, VM; Wood, MB	1
Higashi, T; Ishizaki, T; Nakai, T; Shigemori, K; Yamamura, T	1
Higuchi, H; Satoh, T	1
Kohan, DE; Markewitz, BA; Michael, JR	1
Lew, WY; Yasuda, S	1
Fellström, B; Granstam, E; Granstam, SO; Lind, L	3
Boon, NA; Flint, LL; Fox, KA; Newby, DE; Webb, DJ	1
Frasch, HF; Marshall, BE; Marshall, C	1
Cao, WH; Dewit, D; Ju, KH; Kumada, M; Kuwaki, T; Ling, GY; Ohuchi, T; Onodera, M; Yanagisawa, M	1
Edwards, BS; Kamath, PS; Miller, VM; Rorie, DK; Tyce, GM	1
Cannon, RO; Cardillo, C; Kilcoyne, CM; Panza, JA	1
Bursell, DK; Bursell, SE; Clermont, AC; King, GL; Mori, F	1
McNamee, JE; Porter, LP; Wolf, MB	1
Bayerle-Eder, M; Mayer, G; Pleiner, H; Schmetterer, L; Schmidt, A; Wolzt, M; Zeisner, C	1
Bruck, H; Philipp, T; Schäfers, RF; Siffert, W; Wenzel, RR	1
Hayes, PC; Helmy, A; Jalan, R; Newby, DE; Webb, DJ	1
Baron, AD; Lteif, A; Mather, KJ; Steinberg, HO	1
Ambring, A; Friberg, P; Jeppsson, A; Nilsson, F; Silverborn, M	1
Bernheim, A; Brunner-La Rocca, HP; Julius, B; Kiowski, W; Oechslin, E; Schindler, R	1
Baron, AD; Lteif, A; Mather, KJ; Vaishnava, P	1
Baron, AD; Considine, RV; Fulford, AD; Gelfand, I; Lteif, AA; Mather, KJ	1
Cardillo, C; Di Daniele, N; Mores, N; Rovella, V; Schinzari, F; Tesauro, M; Veneziani, A	1
Barini, A; Cardillo, C; Di Daniele, N; Mores, N; Schinzari, F; Tesauro, M; Veneziani, A	1

Trials

7 trial(s) available for omega-n-methylarginine and bq 123

Article	Year
Reduced responsiveness to endothelin-1 in peripheral resistance vessels of patients with syndrome X. Journal of the American College of Cardiology, 1998, Volume: 31, Issue:7 Topics: Analysis of Variance; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Female; Humans; Male; Microvascular Angina; Middle Aged; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Peptides, Cyclic; Regression Analysis; Vascular Resistance; Vasodilator Agents	1998
The renal and systemic hemodynamic effects of a nitric oxide-synthase inhibitor are reversed by a selective endothelin(a) receptor antagonist in men. Nitric oxide : biology and chemistry, 2001, Volume: 5, Issue:4 Topics: Adult; Blood Flow Velocity; Drug Antagonism; Endothelin Receptor Antagonists; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Humans; Infusion Pumps; Kidney; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Peptides, Cyclic; Receptor, Endothelin A; Renal Circulation	2001
Blunted vascular response to endothelin-a receptor blockade in cyclosporine-treated lung transplant recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2005, Volume: 24, Issue:6 Topics: Adult; Antihypertensive Agents; Cyclosporine; Endothelin A Receptor Antagonists; Female; Forearm; Humans; Immunosuppressive Agents; Infusions, Intra-Arterial; Lung Transplantation; Male; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine; Peptides, Cyclic; Regional Blood Flow; Vascular Resistance	2005
Systemic endothelial dysfunction in adults with cyanotic congenital heart disease. Circulation, 2005, Aug-23, Volume: 112, Issue:8 Topics: Acetylcholine; Adult; Antihypertensive Agents; Cyanosis; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Heart Defects, Congenital; Hemoglobins; Humans; Microcirculation; Nitroprusside; omega-N-Methylarginine; Oxygen; Peptides, Cyclic; Polycythemia; Vasoconstriction; Vasodilation; Vasodilator Agents	2005
Endothelin limits insulin action in obese/insulin-resistant humans. Diabetes, 2007, Volume: 56, Issue:3 Topics: Antihypertensive Agents; Endothelin Receptor Antagonists; Endothelins; Glucose; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Leg; Muscle, Skeletal; Nitric Oxide; Obesity; omega-N-Methylarginine; Peptides, Cyclic; Thinness	2007
Hyperinsulinemia fails to augment ET-1 action in the skeletal muscle vascular bed in vivo in humans. American journal of physiology. Endocrinology and metabolism, 2008, Volume: 295, Issue:6 Topics: Adult; Antihypertensive Agents; Endothelin Receptor Antagonists; Endothelin-1; Female; Humans; Hyperinsulinism; Insulin; Male; Muscle, Skeletal; Nitric Oxide; Obesity; omega-N-Methylarginine; Peptides, Cyclic; Vasoconstriction	2008
Leptin stimulates both endothelin-1 and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome. The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:3 Topics: Adult; Antihypertensive Agents; Atherosclerosis; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Female; Humans; Leptin; Male; Metabolic Syndrome; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Obesity; omega-N-Methylarginine; Peptides, Cyclic; Plethysmography; Receptor, Endothelin A; Risk Factors; Thinness; Vasodilation	2013

Other Studies

26 other study(ies) available for omega-n-methylarginine and bq 123

Article	Year
Effect of endothelin-3 on cytosolic calcium level in vascular endothelium and on smooth muscle contraction. European journal of pharmacology, 1992, Dec-15, Volume: 229, Issue:2-3 Topics: Amino Acid Sequence; Animals; Aorta, Thoracic; Arginine; Calcium; Cytosol; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; omega-N-Methylarginine; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Wistar; Verapamil	1992
A selective agonist of endothelin type B receptor, IRL 1620, stimulates cyclic GMP increase via nitric oxide formation in rat aorta. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Aorta, Thoracic; Arginine; Binding Sites; Calcium; Cyclic GMP; Cytosol; Drug Interactions; Endothelins; Endothelium, Vascular; Kinetics; Male; Membranes; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; omega-N-Methylarginine; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Wistar; Receptors, Endothelin; Stimulation, Chemical; Time Factors	1993
Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells. The Journal of clinical investigation, 1994, Volume: 93, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Calmodulin; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Egtazic Acid; Endothelin Receptor Antagonists; Endothelins; Glomerular Mesangium; Guanylate Cyclase; Hemoglobins; In Vitro Techniques; Kidney Glomerulus; Kinetics; Male; Methylene Blue; Nicardipine; Nitric Oxide; omega-N-Methylarginine; Peptide Fragments; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Sulfonamides	1994
Cerebral vasodilatory effect of high-dose, intravascular endothelin-1: inhibition by NG-monomethyl-L-arginine. Journal of the autonomic nervous system, 1994, Volume: 49 Suppl Topics: Animals; Arginine; Blood Pressure; Blood Volume; Carotid Arteries; Cats; Cerebrovascular Circulation; Endothelin Receptor Antagonists; Endothelins; Injections, Intra-Arterial; Microcirculation; omega-N-Methylarginine; Peptides, Cyclic; Vasodilation	1994
Endothelin receptors mediating functional responses in human small arteries and veins. British journal of pharmacology, 1994, Volume: 111, Issue:2 Topics: Arginine; Arteries; Endothelin Receptor Antagonists; Endothelins; Humans; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; omega-N-Methylarginine; Peptide Fragments; Peptides, Cyclic; Prostaglandin Antagonists; Receptors, Endothelin; Vasodilator Agents; Veins; Viper Venoms	1994
Constriction/dilatation of the cerebral microvessels by intravascular endothelin-1 in cats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1994, Volume: 14, Issue:1 Topics: Animals; Arginine; Blood Pressure; Blood Volume; Carotid Arteries; Cats; Cerebrovascular Circulation; Dose-Response Relationship, Drug; Endothelins; Female; Injections, Intra-Arterial; Male; Microcirculation; Nitric Oxide; omega-N-Methylarginine; Peptides, Cyclic; Time Factors; Vasoconstriction; Vasodilation	1994
Characterization of endothelin receptors and localization of 125I-endothelin-1 binding sites in human umbilical artery. European journal of pharmacology, 1993, Nov-16, Volume: 249, Issue:3 Topics: Arginine; Binding Sites; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Humans; Iodine Radioisotopes; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; omega-N-Methylarginine; Peptides, Cyclic; Receptors, Endothelin; Umbilical Arteries; Vasoconstriction; Vasoconstrictor Agents; Verapamil; Viper Venoms	1993
Different responses of arterioles and venules in rat gastric mucosal microcirculation to endothelin-1 and endothelin-3. Journal of clinical gastroenterology, 1995, Volume: 21 Suppl 1 Topics: Animals; Arterioles; Endothelin-1; Endothelin-3; Enzyme Inhibitors; Gastric Mucosa; Infusions, Intra-Arterial; Male; Muscle, Smooth, Vascular; omega-N-Methylarginine; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Venules	1995
Endothelin-A receptors mediate vascular smooth-muscle response to moderate acidosis in the canine tibial nutrient artery. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 1996, Volume: 14, Issue:5 Topics: Acidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dogs; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Enzyme Inhibitors; Indomethacin; Muscle, Smooth, Vascular; omega-N-Methylarginine; Peptides, Cyclic; Potassium Chloride; Receptor, Endothelin A; Receptors, Endothelin; Tibia; Tibial Arteries	1996
Pharmacological characterization of endothelin-induced rat pulmonary arterial dilatation. British journal of pharmacology, 1997, Volume: 121, Issue:4 Topics: Animals; Endothelin-1; Endothelin-3; Enzyme Inhibitors; Male; Oligopeptides; omega-N-Methylarginine; Peptides, Cyclic; Piperidines; Potassium Channels; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Vasodilation	1997
Endothelin-1 induces vasoconstriction and nitric oxide release via endothelin ET(B) receptors in isolated perfused rat liver. European journal of pharmacology, 1997, Jun-11, Volume: 328, Issue:2-3 Topics: Animals; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; In Vitro Techniques; Liver; Male; Nitric Oxide; Oligopeptides; omega-N-Methylarginine; Oxygen Consumption; Peptide Fragments; Peptides, Cyclic; Piperidines; Portal Pressure; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Receptors, Endothelin; Vasoconstriction	1997
Endothelin-1 inhibits the expression of inducible nitric oxide synthase. The American journal of physiology, 1997, Volume: 272, Issue:6 Pt 1 Topics: Animals; Cell Line; Cycloheximide; Cytokines; Dexamethasone; DNA Primers; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Induction; Enzyme Inhibitors; Epithelium; Glycopeptides; Humans; Lung; Nitrates; Nitric Oxide Synthase; Nitrites; omega-N-Methylarginine; Peptides, Cyclic; Polymerase Chain Reaction; Rats; Receptor, Endothelin A; Recombinant Proteins; RNA, Messenger; Transcription, Genetic	1997
Endothelin-1 ameliorates contractile depression by lipopolysaccharide in cardiac myocytes. The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2 Topics: Animals; Cells, Cultured; Cyclic GMP; Endothelin Receptor Antagonists; Endothelin-1; Heart; Kinetics; Lipopolysaccharides; Myocardial Contraction; Myocardium; omega-N-Methylarginine; Peptides, Cyclic; Rabbits	1997
Endothelium-dependent vasodilation in the uvea of hypertensive and normotensive rats. Current eye research, 1998, Volume: 17, Issue:2 Topics: Acetylcholine; Animals; Endothelin Receptor Antagonists; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Microspheres; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regional Blood Flow; Uvea; Vascular Resistance; Vasodilation	1998
Effects of nitric oxide synthase inhibition and endothelin ETA receptor blockade on haemodynamics in hypertensive rats. Clinical and experimental pharmacology & physiology, 1998, Volume: 25, Issue:9 Topics: Acetylcholine; Animals; Blood Pressure; Coronary Vessels; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hemodynamics; Hydrogen-Ion Concentration; Hypertension; Male; Muscle, Skeletal; Nitric Oxide Synthase; omega-N-Methylarginine; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regional Blood Flow; Renal Circulation; Vasodilator Agents	1998
Effects of endothelin receptor type A antagonism and nitric oxide synthase inhibition on cerebral blood flow in hypertensive rats. Acta physiologica Scandinavica, 1998, Volume: 164, Issue:2 Topics: Acetylcholine; Animals; Blood Flow Velocity; Blood Pressure; Brain Chemistry; Cerebral Arteries; Cerebrovascular Circulation; Endothelin Receptor Antagonists; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Nitric Oxide Synthase; omega-N-Methylarginine; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin A	1998
Endothelin-1 is elevated in monocrotaline pulmonary hypertension. The American journal of physiology, 1999, Volume: 276, Issue:2 Topics: Angiotensin II; Animals; Drug Combinations; Endothelin-1; Endothelins; Enzyme Inhibitors; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Lung; Male; Monocrotaline; Oligopeptides; omega-N-Methylarginine; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Vasoconstriction	1999
Elevation of blood pressure by genetic and pharmacological disruption of the ETB receptor in mice. The American journal of physiology, 1999, Volume: 276, Issue:4 Topics: Animals; Blood; Blood Pressure; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Endothelin-1; Gases; Hydrogen-Ion Concentration; Indomethacin; Injections, Intra-Arterial; Mice; Mice, Inbred Strains; Oligopeptides; omega-N-Methylarginine; Osmolar Concentration; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Respiration	1999
Endothelin-1 modulates intrahepatic resistance in a rat model of noncirrhotic portal hypertension. Hepatology (Baltimore, Md.), 1999, Volume: 30, Issue:2 Topics: Animals; Arginine; Endothelin-1; Hypertension, Portal; In Vitro Techniques; Male; Nitric Oxide; omega-N-Methylarginine; Peptides, Cyclic; Perfusion; Rats; Rats, Inbred F344; Vascular Resistance; Vasoconstriction	1999
Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo. Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:6 Topics: Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Enzyme Inhibitors; Forearm; Humans; Nitric Oxide; Oligopeptides; omega-N-Methylarginine; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Regional Blood Flow; Vascular Resistance; Vasomotor System	2000
Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats. Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:12 Topics: Animals; Blood Flow Velocity; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelin-3; Enzyme Inhibitors; Fluorescein Angiography; Hemodynamics; Injections; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oligopeptides; omega-N-Methylarginine; Peptides, Cyclic; Piperidines; Rats; Rats, Sprague-Dawley; Retinal Vessels; Vitreous Body	2000
Interaction of endothelin-1 and nitric oxide in endothelial barrier failure in the cat hindlimb. Microcirculation (New York, N.Y. : 1994), 2000, Volume: 7, Issue:5 Topics: Animals; Blood Pressure; Capillary Permeability; Cats; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Hindlimb; Microcirculation; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; omega-N-Methylarginine; Penicillamine; Peptides, Cyclic; Perfusion; Protein Transport; Receptors, Endothelin; Vascular Resistance	2000
Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation. Pharmacogenetics, 2002, Volume: 12, Issue:6 Topics: Adrenergic alpha-Antagonists; Adult; Alleles; Angiotensin II; Drug Synergism; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Heterotrimeric GTP-Binding Proteins; Heterozygote; Humans; Laser-Doppler Flowmetry; Male; Microcirculation; Nitric Oxide Synthase; Norepinephrine; Oligopeptides; omega-N-Methylarginine; Peptides, Cyclic; Piperidines; Protein Subunits; Skin; Vasoconstriction; Vasoconstrictor Agents; Yohimbine	2002
Enhanced vasodilatation to endothelin antagonism in patients with compensated cirrhosis and the role of nitric oxide. Gut, 2003, Volume: 52, Issue:3 Topics: Adult; Case-Control Studies; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Female; Forearm; Hemodynamics; Humans; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peptides, Cyclic; Plethysmography; Regional Blood Flow; Vasodilation	2003
Interactions between endothelin and nitric oxide in the regulation of vascular tone in obesity and diabetes. Diabetes, 2004, Volume: 53, Issue:8 Topics: Blood Pressure; Diabetes Mellitus; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Obesity; omega-N-Methylarginine; Peptides, Cyclic; Reference Values; Vascular Resistance	2004
Vascular Effects of Obestatin in Lean and Obese Subjects. Diabetes, 2017, Volume: 66, Issue:5 Topics: Adult; Case-Control Studies; Endothelin A Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Ghrelin; Humans; Male; Nitric Oxide; Obesity, Abdominal; omega-N-Methylarginine; Peptides, Cyclic; Regional Blood Flow; Vasoconstriction; Vasodilation	2017