Page last updated: 2024-09-03

omega-n-methylarginine and ascorbic acid

omega-n-methylarginine has been researched along with ascorbic acid in 53 studies

Compound Research Comparison

Studies (omega-n-methylarginine)	Trials (omega-n-methylarginine)	Recent Studies (post-2010) (omega-n-methylarginine)	Studies (ascorbic acid)	Trials (ascorbic acid)	Recent Studies (post-2010) (ascorbic acid)
4,411	344	336	45,261	2,497	11,176

Protein Interaction Comparison

Protein	Taxonomy	ascorbic acid (IC50)
Chain A, Hyaluronidase, phage associated	Streptococcus pyogenes	1000
Urease	Canavalia ensiformis (jack bean)	8.59
Solute carrier family 23 member 1	Homo sapiens (human)	156

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (15.09)	18.2507
2000's	38 (71.70)	29.6817
2010's	7 (13.21)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Choi, SU; Kim, CS; Kim, KH; Kim, SY; Lee, JH; Lee, KR; Moon, E; Park, YJ	1
Arakawa, N; Drexler, H; Hornig, B; Kohler, C	1
Ghiadoni, L; Magagna, A; Salvetti, A; Taddei, S; Virdis, A	1
Anggard, E; Hink, U; Münzel, T; Skatchkov, MP; Sperling, D	1
Hitomi, K; Maki, H; Mizutani, A; Torii, Y; Tsukagoshi, N	1
Dijkhorst-Oei, LT; Koomans, HA; Rabelink, TJ; Stroes, ES	1
Drexler, H; Hornig, B	1
Fink, MP; Hodin, RA; Unno, N	1
Buralli, S; Ghiadoni, L; Salvetti, A; Taddei, S; Virdis, A	1
Brockhoff, C; Heitzer, T; Henne, S; Mayer, B; Meinertz, T; Mollnau, H; Münzel, T; Warnholtz, A	1
Karanth, S; Mastronardi, C; McCann, SM; Walczewska, A; Yu, WH	1
Buralli, S; Gennazzani, A; Ghiadoni, L; Lombardo, M; Petraglia, F; Pinto, S; Salvetti, A; Taddei, S; Virdis, A	1
Büttner, K; Drexler, H; Hornig, B; Landmesser, U; Merten, R; Spiekermann, S	1
Franzoni, F; Galetta, F; Ghiadoni, L; Giusti, C; Salvetti, A; Salvetti, G; Taddei, S; Virdis, A	1
Fontana, D; Fratta, L; Izzo, R; Lembo, G; Marino, G; Pilato, G; Trimarco, B; Vecchione, C	1
Candigliota, M; Ceravolo, R; Chello, M; Cloro, C; Maio, R; Mastroroberto, P; Mattioli, PL; Mongiardo, A; Perticone, F; Scozzafava, A	1
Harada, M; Hayakawa, M; Hayakawa, T; Ito, T; Matsui, H; Mokuno, S; Murase, K; Numaguchi, Y; Okumura, K; Osanai, H; Toki, Y	1
Ahlersmann, D; Christoph, A; Drexler, H; Hornig, B; Kohler, C; Landmesser, U; Spiekermann, S; Tatge, H	1
Favilla, S; Ghiadoni, L; Magagna, A; Pompella, A; Salvetti, A; Taddei, S; Virdis, A	1
Dobrev, D; Grossmann, M; Himmel, HM; Kirch, W; Ravens, U	1
Campagnola, M; Cominacini, L; Davoli, A; Garbin, U; Lo Cascio, V; Pasini, AF; Pastorino, AM; Rigoni, A; Sawamura, T	1
Bernini, G; Ghiadoni, L; Magagna, A; Salvetti, A; Salvetti, G; Taddei, S; Virdis, A	1
Karanth, S; Mastronardi, CA; McCann, SM; Walczewska, A; Yu, WH	1
Lundman, P; Nilsson, L; Pernow, J; Tornvall, P	1
Hare, JM; Harrison, RW; Kass, DA; Marbán, E; Mudrick, D; Paolocci, N; Saavedra, WF; Skaf, MW; St John, ME; Stewart, GC; Xie, JS; Zeichner, J	1
Kim, CH; Lee, MM; Oh, BH; On, YK; Park, YB	1
Choi, YS; Kim, CH; Lee, MM; Oh, BH; On, YK; Park, YB; Sohn, DW	1
Azenabor, AA; Chaudhry, AU	1
Karanth, S; Mastronardi, CA; McCann, SM; Yu, WH	2
Delles, C; John, S; Klingbeil, AU; Schmidt, BM; Schmieder, RE; Schneider, MP	1
Caccitolo, JA; Hamner, CE; Hisamochi, K; Pearson, PJ; Schaff, HV; Takayama, H	1
Bernini, G; Fruzzetti, F; Genazzani, AR; Pinto, S; Salvetti, A; Salvetti, G; Taddei, S; Versari, D; Virdis, A	1
Breuer, S; Busse, R; Dimmeler, S; Fichtlscherer, S; Fleming, I; Zeiher, AM	1
Barnabé, N; Hasinoff, BB; Marusak, RA	1
Delles, C; Fleischmann, EF; Fleischmann, I; Oehmer, S; Schmieder, RE; Schneider, MP	1
Clapp, BR; Hingorani, AD; Kharbanda, RK; MacAllister, RJ; Mohamed-Ali, V; Stephens, JW; Vallance, P	1
Antonioli, L; Bernardini, N; Blandizzi, C; Colucci, R; Del Tacca, M; Duranti, E; Fornai, M; Pinto, S; Salvetti, A; Segnani, C; Taddei, S; Virdis, A	1
Delles, C; Jacobi, J; John, S; Schmieder, RE; Schneider, MP	1
Mak, S; Newton, GE; Overgaard, CB	1
Franzoni, F; Galetta, F; Ghiadoni, L; Salvetti, A; Santoro, G; Taddei, S; Virdis, A	1
Ferlitsch, A; Homoncik, M; Mittermayer, F; Peck-Radosavljevic, M; Pleiner, J; Schaller, G; Wolzt, M	1
Chayama, K; Goto, C; Hara, K; Higashi, Y; Jitsuiki, D; Kimura, M; Nakagawa, K; Nishioka, K; Noma, K; Oshima, T; Umemura, T; Yoshizumi, M	1
Delles, C; Oehmer, S; Schlaich, MP; Schmidt, BM; Schmieder, RE; Schneider, MP	1
Cipriano, A; Franzoni, F; Galetta, F; Ghiadoni, L; Magagna, A; Salvetti, A; Taddei, S; Versari, D; Virdis, A	1
Ferlitsch, A; Kapiotis, S; MacAllister, RJ; Marsik, C; Mittermayer, F; Pleiner, J; Schaller, G; Wolzt, M; Ziegler, S	1
Delles, C; Ott, C; Ritt, M; Schmieder, RE; Schneider, MP	1
Ambrogini, E; Banti, C; Bernini, G; Carrara, D; Cetani, F; Ghiadoni, L; Giannarelli, C; Marcocci, C; Pinchera, A; Taddei, S; Virdis, A	1
Alves, MJ; Brum, PC; dos Santos, MR; Martinez, DG; Middlekauff, HR; Nazaré Nunes Alves, MJ; Negrão, CE; Nobre, TS; Pereira Barretto, AC; Rondon, MU	1
Heo, JH; Jang, JH; Kim, MH; Lee, MW; Oh, MH	1
Bos, GM; Briedé, JJ; Germeraad, WT; Huijskens, MJ; Koller, N; Schnijderberg, MC; Senden-Gijsbers, BL; Walczak, M	1
Bernardini, N; Blandizzi, C; Colucci, R; Duranti, E; Ippolito, C; Lorenzini, G; Taddei, S; Tirotta, E; Virdis, A	1
Barrett-O'Keefe, Z; Conklin, JD; Ives, SJ; Layec, G; Reese, V; Richardson, RS; Trinity, JD; Witman, MA; Wray, DW; Zhao, J	1

Reviews

1 review(s) available for omega-n-methylarginine and ascorbic acid

Article	Year
Endothelial dysfunction in human disease. Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1 Topics: Acetylcholine; Ascorbic Acid; Cardiac Output, Low; Coronary Disease; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypercholesterolemia; Hyperemia; Lipoproteins, LDL; omega-N-Methylarginine; Radial Artery	1999

Trials

15 trial(s) available for omega-n-methylarginine and ascorbic acid

Article	Year
Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure. Circulation, 1998, Feb-03, Volume: 97, Issue:4 Topics: Administration, Oral; Adult; Ascorbic Acid; Cardiac Output, Low; Chronic Disease; Endothelium, Vascular; Enzyme Inhibitors; Humans; Injections, Intra-Arterial; Male; Middle Aged; omega-N-Methylarginine; Radial Artery; Regional Blood Flow; Time Factors; Treatment Outcome; Ultrasonography; Vasodilation	1998
Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation, 1998, Jun-09, Volume: 97, Issue:22 Topics: Acetylcholine; Adult; Antioxidants; Ascorbic Acid; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Hypertension; Indomethacin; Male; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Vasodilation	1998
Acute simultaneous stimulation of nitric oxide and oxygen radicals by angiotensin II in humans in vivo. Journal of cardiovascular pharmacology, 1999, Volume: 33, Issue:3 Topics: Adult; Angiotensin II; Ascorbic Acid; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Forearm; Free Radical Scavengers; Humans; Infusions, Intra-Arterial; Male; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Plethysmography; Reactive Oxygen Species; Regional Blood Flow; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents	1999
Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes. Circulation, 2000, Jun-27, Volume: 101, Issue:25 Topics: Acetylcholine; Adult; Aged; Aging; Antioxidants; Ascorbic Acid; Biological Availability; Drug Combinations; Enzyme Inhibitors; Exercise; Female; Forearm; Humans; Male; Middle Aged; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Regional Blood Flow; Vasodilator Agents	2000
Effects of atorvastatin and vitamin C on endothelial function of hypercholesterolemic patients. Atherosclerosis, 2000, Volume: 152, Issue:2 Topics: Acetylcholine; Adult; Anticholesteremic Agents; Antioxidants; Ascorbic Acid; Atorvastatin; Blood Flow Velocity; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Female; Forearm; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Infusions, Intra-Arterial; Male; Middle Aged; Nitroprusside; omega-N-Methylarginine; Plethysmography; Pyrroles; Vasodilation; Vasodilator Agents	2000
Comparative effect of ace inhibition and angiotensin II type 1 receptor antagonism on bioavailability of nitric oxide in patients with coronary artery disease: role of superoxide dismutase. Circulation, 2001, Feb-13, Volume: 103, Issue:6 Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Ascorbic Acid; Biological Availability; Coronary Disease; Endothelium, Vascular; Enzyme Activation; Humans; Losartan; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidative Stress; Radial Artery; Ramipril; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Regional Blood Flow; Superoxide Dismutase; Time Factors; Vasodilation	2001
Effects of angiotensin converting enzyme inhibitor and calcium antagonist on endothelial function in patients with essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:3 Topics: Adult; Aged; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Ascorbic Acid; Calcium Channel Blockers; Enalapril; Endothelium, Vascular; Female; Forearm; Humans; Hypertension; Male; Middle Aged; Nitroprusside; omega-N-Methylarginine; Regional Blood Flow	2002
Improvement of endothelial function by amlodipine and vitamin C in essential hypertension. The Korean journal of internal medicine, 2002, Volume: 17, Issue:2 Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Ascorbic Acid; Calcium Channel Blockers; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine; Vasodilation	2002
Effect of oral contraceptives on endothelial function in the peripheral microcirculation of healthy women. Journal of hypertension, 2003, Volume: 21, Issue:12 Topics: Acetylcholine; Adult; Antioxidants; Ascorbic Acid; Biomarkers; Cholesterol, LDL; Contraceptives, Oral; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Humans; Hypercholesterolemia; Microcirculation; Nitroprusside; omega-N-Methylarginine; Reference Values; Regional Blood Flow; Triglycerides; Vasodilation; Vasodilator Agents; Women's Health	2003
Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease. Circulation, 2004, Jan-20, Volume: 109, Issue:2 Topics: Acetylcholine; Adult; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Blood Proteins; Coronary Artery Disease; Cytochrome P-450 CYP2C9; Endothelium, Vascular; Enzyme Inhibitors; Forearm; Humans; Male; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Oxidation-Reduction; Regional Blood Flow; Sulfaphenazole; Vasodilation; Vasodilator Agents	2004
Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress. Cardiovascular research, 2004, Oct-01, Volume: 64, Issue:1 Topics: Adult; Albuminuria; Analysis of Variance; Arginine; Ascorbic Acid; Biological Availability; Bradykinin; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Forearm; Humans; Male; Nitric Oxide; Nitroglycerin; Norepinephrine; omega-N-Methylarginine; Oxidative Stress; Plethysmography; Regional Blood Flow; Statistics, Nonparametric; Typhoid-Paratyphoid Vaccines; Vasoconstrictor Agents; Vasodilator Agents	2004
Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. American heart journal, 2005, Volume: 149, Issue:3 Topics: Acetylcholine; Adult; Aged; Ascorbic Acid; Atorvastatin; Biological Availability; C-Reactive Protein; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Female; Forearm; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipid Metabolism; Male; Middle Aged; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Pyridines; Pyrroles; Regional Blood Flow; Vasodilation	2005
Effect of vitamin C and L-NMMA on the inotropic response to dobutamine in patients with heart failure. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:6 Topics: Ascorbic Acid; Blood Pressure; Cardiotonic Agents; Dobutamine; Drug Combinations; Heart Failure; Heart Rate; Humans; Male; Middle Aged; Myocardial Contraction; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Treatment Outcome; Ventricular Dysfunction, Left	2005
Effects of nitric oxide synthase inhibition and L-arginine on renal haemodynamics in young patients at high cardiovascular risk. Atherosclerosis, 2007, Volume: 192, Issue:1 Topics: Adult; Antioxidants; Arginine; Ascorbic Acid; Humans; Hypercholesterolemia; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidative Stress; Renal Plasma Flow; Substrate Specificity	2007
Intra-arterial vitamin C prevents endothelial dysfunction caused by ischemia-reperfusion. Atherosclerosis, 2008, Volume: 197, Issue:1 Topics: Adult; Antioxidants; Ascorbic Acid; Endothelium, Vascular; Enzyme Inhibitors; Forearm; Humans; Injections, Intra-Arterial; Male; Middle Aged; omega-N-Methylarginine; Oxidative Stress; Peripheral Vascular Diseases; Plethysmography; Regional Blood Flow; Reperfusion Injury; Vasodilation	2008

Other Studies

37 other study(ies) available for omega-n-methylarginine and ascorbic acid

Article	Year
Anti-inflammatory and antitumor phenylpropanoid sucrosides from the seeds of Raphanus sativus. Bioorganic & medicinal chemistry letters, 2015, Jan-01, Volume: 25, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Humans; Mice; Oxidative Stress; Phenylpropionates; Plant Extracts; Raphanus; Seeds	2015
Quantification of superoxide radical formation in intact vascular tissue using a Cypridina luciferin analog as an alternative to lucigenin. Biochemical and biophysical research communications, 1998, Jul-20, Volume: 248, Issue:2 Topics: Acridines; Animals; Aorta; Ascorbic Acid; Cell Extracts; Electron Spin Resonance Spectroscopy; Luminescent Measurements; Muscle, Smooth, Vascular; omega-N-Methylarginine; Pyrazines; Rabbits; Superoxide Dismutase; Superoxides	1998
Ascorbate-dependent enhancement of nitric oxide formation in activated macrophages. Nitric oxide : biology and chemistry, 1998, Volume: 2, Issue:4 Topics: Animals; Ascorbic Acid; Cell Line; Dithiothreitol; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Protein Biosynthesis; RNA, Messenger; Transcription, Genetic	1998
Acidic conditions exacerbate interferon-gamma-induced intestinal epithelial hyperpermeability: role of peroxynitrous acid. Critical care medicine, 1999, Volume: 27, Issue:8 Topics: Adenosine Triphosphate; Ascorbic Acid; Caco-2 Cells; Cell Membrane Permeability; Cyclic N-Oxides; Dimethyl Sulfoxide; Drug Evaluation, Preclinical; Electric Impedance; Free Radical Scavengers; Humans; Hydrogen-Ion Concentration; Imidazoles; Interferon-gamma; Intestinal Mucosa; Nitric Oxide; Nitric Oxide Synthase; Nitrous Acid; omega-N-Methylarginine; Peroxynitrous Acid; Time Factors	1999
Vasodilation to bradykinin is mediated by an ouabain-sensitive pathway as a compensatory mechanism for impaired nitric oxide availability in essential hypertensive patients. Circulation, 1999, Sep-28, Volume: 100, Issue:13 Topics: Adaptation, Physiological; Adult; Antioxidants; Ascorbic Acid; Biological Availability; Bradykinin; Drug Combinations; Enzyme Inhibitors; Female; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Ouabain; Reference Values; Vasodilation; Vasodilator Agents	1999
Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers : evidence for a dysfunctional nitric oxide synthase. Circulation research, 2000, Feb-04, Volume: 86, Issue:2 Topics: Acetylcholine; Antioxidants; Ascorbic Acid; Biopterins; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Regional Blood Flow; Serotonin; Smoking; Vasodilation	2000
Ascorbic acid acts as an inhibitory transmitter in the hypothalamus to inhibit stimulated luteinizing hormone-releasing hormone release by scavenging nitric oxide. Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-15, Volume: 97, Issue:4 Topics: Animals; Ascorbic Acid; Calcium; Free Radical Scavengers; Gonadotropin-Releasing Hormone; Hypothalamus; Male; Models, Neurological; N-Methylaspartate; Neurotransmitter Agents; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Oxidation-Reduction; Potassium; Rats; Rats, Sprague-Dawley	2000
Mechanisms responsible for endothelial dysfunction associated with acute estrogen deprivation in normotensive women. Circulation, 2000, May-16, Volume: 101, Issue:19 Topics: Acetylcholine; Adult; Arginine; Ascorbic Acid; Blood Pressure; Cardiovascular Agents; Endothelium, Vascular; Enzyme Inhibitors; Estrogen Replacement Therapy; Estrogens; Female; Forearm; Humans; Indomethacin; Leiomyoma; Middle Aged; omega-N-Methylarginine; Ovariectomy; Postoperative Period; Reference Values; Regional Blood Flow; Uterine Neoplasms; Vasodilation; Vasodilator Agents	2000
Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Circulation, 2000, May-16, Volume: 101, Issue:19 Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Coronary Disease; Coronary Vessels; Drug Combinations; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Space; Humans; Hypercholesterolemia; Male; Middle Aged; omega-N-Methylarginine; Radial Artery; Reactive Oxygen Species; Superoxide Dismutase; Vasodilation	2000
Noradrenergic vascular hyper-responsiveness in human hypertension is dependent on oxygen free radical impairment of nitric oxide activity. Circulation, 2000, Aug-01, Volume: 102, Issue:5 Topics: Adult; Ascorbic Acid; Blood Pressure; Female; Forearm; Humans; Hypertension; Infusions, Intravenous; Male; Nitric Oxide; Norepinephrine; omega-N-Methylarginine; Reference Values; Regional Blood Flow; Vasoconstriction	2000
Ascorbic acid improves postischemic vasodilatation impaired by infusion of soybean oil into canine iliac artery. Journal of cardiovascular pharmacology, 2000, Volume: 36, Issue:6 Topics: Animals; Ascorbic Acid; Cholesterol; Coronary Circulation; Dogs; Enzyme Inhibitors; Fat Emulsions, Intravenous; Female; Iliac Artery; Infusions, Intravenous; Ischemia; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; omega-N-Methylarginine; Soybean Oil; Triglycerides; Vasodilation	2000
Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:3 Topics: Acetylcholine; Antioxidants; Ascorbic Acid; Blood Pressure; Calcium Channel Blockers; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidative Stress; Regional Blood Flow; Time Factors; Vasodilation	2001
Ascorbic acid-induced modulation of venous tone in humans. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:3 Topics: Adult; Animals; Ascorbic Acid; Aspirin; Calcium; Cattle; Cells, Cultured; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hand; Humans; Infusions, Intravenous; Male; Methylene Blue; Muscle, Smooth, Vascular; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylephrine; Potassium Channels; Vasodilation; Veins	2001
The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide. The Journal of biological chemistry, 2001, Apr-27, Volume: 276, Issue:17 Topics: Allopurinol; Animals; Antibodies, Monoclonal; Antioxidants; Aorta; Ascorbic Acid; Aspirin; Bradykinin; Catecholamines; Cattle; Cells, Cultured; CHO Cells; Chromans; Cricetinae; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Flow Cytometry; Free Radical Scavengers; Hemostatics; Humans; Imidazolines; Lipoproteins, LDL; Mice; Nitric Oxide; omega-N-Methylarginine; Oxygen; Probucol; Protein Binding; Reactive Oxygen Species; Receptors, LDL; Receptors, Oxidized LDL; Scavenger Receptors, Class E; Superoxides; Thrombin; Time Factors	2001
Age-related reduction of NO availability and oxidative stress in humans. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:2 Topics: Acetylcholine; Adult; Age Factors; Aged; Ascorbic Acid; Drug Antagonism; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Humans; Hypertension; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxidative Stress; Regional Blood Flow; Vasodilation; Vasodilator Agents	2001
Ascorbic acid stimulates gonadotropin release by autocrine action by means of NO. Proceedings of the National Academy of Sciences of the United States of America, 2001, Sep-25, Volume: 98, Issue:20 Topics: Animals; Ascorbic Acid; Enzyme Inhibitors; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Kinetics; Luteinizing Hormone; Male; Nitroprusside; omega-N-Methylarginine; Pituitary Gland, Anterior; Potassium; Rats; Rats, Sprague-Dawley	2001
A triglyceride-rich fat emulsion and free fatty acids but not very low density lipoproteins impair endothelium-dependent vasorelaxation. Atherosclerosis, 2001, Volume: 159, Issue:1 Topics: Acetylcholine; Animals; Antioxidants; Ascorbic Acid; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Fat Emulsions, Intravenous; Fatty Acids, Nonesterified; Femoral Artery; In Vitro Techniques; Lipoproteins, VLDL; Male; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oleic Acid; omega-N-Methylarginine; Palmitic Acid; Penicillamine; Rats; Rats, Sprague-Dawley; Triglycerides; Vasodilation; Vasodilator Agents	2001
Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circulation research, 2002, Feb-22, Volume: 90, Issue:3 Topics: Allopurinol; Animals; Antioxidants; Ascorbic Acid; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Dogs; Energy Metabolism; Fluorescent Antibody Technique; Free Radical Scavengers; Hemodynamics; Infusions, Intravenous; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; omega-N-Methylarginine; Signal Transduction; Xanthine Oxidase	2002
Chlamydia pneumoniae survival in macrophages is regulated by free Ca2+ dependent reactive nitrogen and oxygen species. The Journal of infection, 2003, Volume: 46, Issue:2 Topics: Animals; Ascorbic Acid; Calcium; Catalase; Cell Survival; Chlamydia Infections; Chlamydophila pneumoniae; Enzyme Inhibitors; Glutathione; Macrophages; Mice; omega-N-Methylarginine; Reactive Nitrogen Species; Reactive Oxygen Species; Superoxide Dismutase; Up-Regulation	2003
Vitamin E stimulates luteinizing hormone-releasing hormone and ascorbic acid release from medial basal hypothalami of adult male rats. Experimental biology and medicine (Maywood, N.J.), 2003, Volume: 228, Issue:7 Topics: alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Hypothalamus, Middle; Male; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Solubility; Vitamin E	2003
Vitamin C augments the renal response to L-arginine in smokers. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2003, Volume: 18, Issue:8 Topics: Adolescent; Adult; Antioxidants; Arginine; Ascorbic Acid; Blood Pressure; Drug Synergism; Heart Rate; Humans; Infusions, Intravenous; Kidney; Male; omega-N-Methylarginine; Regional Blood Flow; Smoking; Vasodilation	2003
A novel antioxidant, EPC-K1, stimulates endothelial nitric oxide production and scavenges hydroxyl radicals. Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:12 Topics: Animals; Antioxidants; Arginine; Ascorbic Acid; Coronary Vessels; Dinoprost; Dogs; Endothelium, Vascular; Female; Free Radical Scavengers; Hydroxyl Radical; Male; Models, Animal; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Vasodilation; Vitamin E	2003
Prevention of doxorubicin-induced damage to rat heart myocytes by arginine analog nitric oxide synthase inhibitors and their enantiomers. Nitric oxide : biology and chemistry, 2003, Volume: 9, Issue:4 Topics: Animals; Animals, Newborn; Antibiotics, Antineoplastic; Arginine; Ascorbic Acid; Benzoquinones; Doxorubicin; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Free Radical Scavengers; L-Lactate Dehydrogenase; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Stereoisomerism	2003
Inhibition of melatonin-induced ascorbic acid and LHRH release by a nitric oxide synthase and cyclic GMP inhibitor. Experimental biology and medicine (Maywood, N.J.), 2004, Volume: 229, Issue:7 Topics: Aminoquinolines; Animals; Ascorbic Acid; Cyclic GMP; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Guanylate Cyclase; Male; Melatonin; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley	2004
Increased response of renal perfusion to the antioxidant vitamin C in type 2 diabetes. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2004, Volume: 19, Issue:10 Topics: Aged; Antioxidants; Arginine; Ascorbic Acid; Case-Control Studies; Diabetes Mellitus, Type 2; Drug Combinations; Enzyme Inhibitors; Female; Humans; Hypertension; Infusions, Intravenous; Male; Middle Aged; omega-N-Methylarginine; Renal Circulation	2004
Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: role of inducible nitric-oxide synthase and oxidative stress. The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:3 Topics: Acetylcholine; Animals; Ascorbic Acid; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytokines; Endothelium, Vascular; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Norepinephrine; omega-N-Methylarginine; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Shock, Septic; Superoxide Dismutase; Vascular Resistance; Vasoconstriction	2005
Endothelium-dependent vasodilation and carotid artery wall remodeling in athletes and sedentary subjects. Atherosclerosis, 2006, Volume: 186, Issue:1 Topics: Acetylcholine; Adult; Aging; Ascorbic Acid; Blood Flow Velocity; Carotid Artery, Common; Endothelium, Vascular; Female; Follow-Up Studies; Forearm; Free Radical Scavengers; Humans; Injections, Intra-Arterial; Male; omega-N-Methylarginine; Plethysmography; Reference Values; Risk Factors; Sports; Ultrasonography, Doppler, Pulsed; Vasodilation; Vasodilator Agents	2006
Vasoconstrictor hyporeactivity can be reversed by antioxidants in patients with advanced alcoholic cirrhosis of the liver and ascites. Critical care medicine, 2005, Volume: 33, Issue:9 Topics: Angiotensin II; Antioxidants; Ascites; Ascorbic Acid; Female; Forearm; Humans; Liver Cirrhosis, Alcoholic; Male; Middle Aged; Norepinephrine; omega-N-Methylarginine; Oxidative Stress; Vasoconstriction; Vasoconstrictor Agents	2005
Smoking, endothelial function, and Rho-kinase in humans. Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:12 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Adult; Antioxidants; Ascorbic Acid; Endothelium, Vascular; Enzyme Inhibitors; Forearm; Humans; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Nitroprusside; omega-N-Methylarginine; Plethysmography; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Regional Blood Flow; rho-Associated Kinases; Smoking; Vasodilator Agents	2005
Identification of a cytochrome P450 2C9-derived endothelium-derived hyperpolarizing factor in essential hypertensive patients. Journal of the American College of Cardiology, 2006, Aug-01, Volume: 48, Issue:3 Topics: Acetylcholine; Adult; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Biological Factors; Bradykinin; Case-Control Studies; Cytochrome P-450 CYP2C9; Drug Combinations; Drug Synergism; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Humans; Hypertension; Male; Microcirculation; Middle Aged; Nitroprusside; omega-N-Methylarginine; Regional Blood Flow; Sulfaphenazole; Vasodilation; Vasodilator Agents	2006
Impact of the endothelial nitric oxide synthase gene G894T polymorphism on renal endothelial function in patients with type 2 diabetes. Pharmacogenetics and genomics, 2008, Volume: 18, Issue:8 Topics: Alleles; Analysis of Variance; Arginine; Ascorbic Acid; Body Mass Index; Cholesterol, HDL; Diabetes Mellitus, Type 2; Endothelium; Female; Genotype; Guanine; Hemodynamics; Homozygote; Humans; Kidney; Male; Middle Aged; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Polymorphism, Single Nucleotide; Renal Plasma Flow; Thymine; Triglycerides	2008
The sulfaphenazole-sensitive pathway acts as a compensatory mechanism for impaired nitric oxide availability in patients with primary hyperparathyroidism. Effect of surgical treatment. The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:2 Topics: Adult; Aged; Aryl Hydrocarbon Hydroxylases; Ascorbic Acid; Biological Factors; Cytochrome P-450 CYP2C9; Endothelium, Vascular; Female; Humans; Hyperparathyroidism, Primary; Middle Aged; Nitric Oxide; omega-N-Methylarginine; Parathyroidectomy; Sulfaphenazole; Vasodilation	2010
Mechanisms of blunted muscle vasodilation during peripheral chemoreceptor stimulation in heart failure patients. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:3 Topics: Adult; Ascorbic Acid; Case-Control Studies; Chemoreceptor Cells; Forearm; Heart Failure; Hemodynamics; Humans; Hypoxia; Middle Aged; Muscle, Smooth, Vascular; omega-N-Methylarginine; Oxidative Stress; Phentolamine; Regional Blood Flow; Sympathetic Nervous System; Vasoconstriction; Vasodilation	2012
The comparison of DPPH-scavenging capacity and anti-inflammatory effects of phenolic compounds isolated from the stems of Stewartia koreana Nakai. Natural product research, 2014, Volume: 28, Issue:17 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Biphenyl Compounds; Free Radical Scavengers; Furans; Lignans; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Nitric Oxide; omega-N-Methylarginine; Oxidation-Reduction; Phenols; Picrates; Plant Stems; Theaceae	2014
Technical advance: ascorbic acid induces development of double-positive T cells from human hematopoietic stem cells in the absence of stromal cells. Journal of leukocyte biology, 2014, Volume: 96, Issue:6 Topics: Antigens, Differentiation, T-Lymphocyte; Antioxidants; Ascorbic Acid; CD4 Antigens; CD8 Antigens; Cell Division; Cells, Cultured; Citrulline; Coculture Techniques; Filgrastim; Gene Expression Profiling; Gene Rearrangement, T-Lymphocyte; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Immunomagnetic Separation; Integrins; Lymphopoiesis; Nitric Oxide; omega-N-Methylarginine; Primary Cell Culture; Receptors, Chemokine; Recombinant Proteins; Stromal Cells; T-Lymphocyte Subsets	2014
Ghrelin restores nitric oxide availability in resistance circulation of essential hypertensive patients: role of NAD(P)H oxidase. European heart journal, 2015, Nov-14, Volume: 36, Issue:43 Topics: Analysis of Variance; Antioxidants; Ascorbic Acid; Case-Control Studies; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Ghrelin; Humans; Hypertension; Infusions, Intra-Arterial; Male; Middle Aged; NADPH Oxidases; Nitric Oxide; omega-N-Methylarginine; Oxidative Stress; Reactive Oxygen Species; Superoxides; Vasodilator Agents	2015
Ascorbic acid improves brachial artery vasodilation during progressive handgrip exercise in the elderly through a nitric oxide-mediated mechanism. American journal of physiology. Heart and circulatory physiology, 2016, 03-15, Volume: 310, Issue:6 Topics: Aged; Ascorbic Acid; Brachial Artery; Enzyme Inhibitors; Exercise; Female; Free Radicals; Hand Strength; Humans; Infusions, Intra-Arterial; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Regional Blood Flow; Vasodilation	2016