Page last updated: 2024-09-03

omega-n-methylarginine and allopurinol

omega-n-methylarginine has been researched along with allopurinol in 23 studies

Compound Research Comparison

Studies
(omega-n-methylarginine)
Trials
(omega-n-methylarginine)
Recent Studies (post-2010)
(omega-n-methylarginine)
Studies
(allopurinol)
Trials
(allopurinol)
Recent Studies (post-2010) (allopurinol)
4,41134433615,0967433,363

Protein Interaction Comparison

ProteinTaxonomyomega-n-methylarginine (IC50)allopurinol (IC50)
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase Rattus norvegicus (Norway rat)3.3765
Xanthine dehydrogenase/oxidaseHomo sapiens (human)3.1861
Xanthine dehydrogenase/oxidaseBos taurus (cattle)5.0758
Histamine H3 receptorCavia porcellus (domestic guinea pig)8.69

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (52.17)18.2507
2000's11 (47.83)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Groot, H; Komarov, P; Sies, H; Wang, JF1
Benicourt, C; Junien, JL; Lockhart, BP; Privat, A1
Chang, CH; Hsieh, HC; Hsieh, MJ; Kao, CL; Lin, PJ; Tsai, KT; Yao, PC1
Cosentino, F; Katusić, ZS; Schugel, J; Vanhoutte, PM1
Chen, F; Demers, LM; Gaydos, LJ; Kuhn, DC1
Hou, JW; Wang, JC; Xin, WJ; Zhao, BL1
Chumley, P; Freeman, BA; Gutierrez, HH; Nieves, B; Rivera, A1
Deliconstantinos, G; Villiotou, V1
Adler, KB; Akley, NJ; Fischer, BM; Li, C; Rochelle, LG; Wright, DT1
Allen, S; Anastasiou, N; Chester, A; Paniagua, R; Yacoub, M1
Akaike, T; Fujii, S; Maeda, H; Ozawa, A; Setoguchi, K; Suga, M; Umezawa, K1
Damais, C; Dornand, J; Dugas, B; Dugas, N; Gross, A; Kolb, JP; Spiesser, S; Vouldoukis, I1
Campagnola, M; Cominacini, L; Davoli, A; Garbin, U; Lo Cascio, V; Pasini, AF; Pastorino, AM; Rigoni, A; Sawamura, T1
Hare, JM; Harrison, RW; Kass, DA; Marbán, E; Mudrick, D; Paolocci, N; Saavedra, WF; Skaf, MW; St John, ME; Stewart, GC; Xie, JS; Zeichner, J1
Barenz, T; Guthikonda, S; Haynes, WG; Sinkey, C1
Bachschmid, M; Thurau, S; Ullrich, V; Zou, MH1
Arnold, RE; Weigent, DA1
Huang, T; Lombard, JH; Mori, T; Zhu, J1
Bartels, H; Berkels, R; Breitenbach, T; Klaus, W; Roesen, R; Taubert, D1
Chou, YC; Chu, JJ; Chu, Y; Chueh, HY; Lin, PJ; Liu, HP; Wu, YC1
Lianos, EA; McCarthy, ET; Savin, VJ; Sharma, M1
Ahluwalia, A; Ahmed, Z; Benjamin, N; Chu, WL; Hobbs, AJ; Khoshbin, E; Lecomte, FM; Lovell, MJ; Milsom, AB; Perrett, D; Qureshi, S; Raimondo, C; Rathod, KS; Uppal, R; Webb, AJ1
Cleland, SJ; Dawson, J; Harrow, C; Lees, KR; Quinn, T; Walters, MR; Weir, CJ1

Trials

2 trial(s) available for omega-n-methylarginine and allopurinol

ArticleYear
Xanthine oxidase inhibition reverses endothelial dysfunction in heavy smokers.
    Circulation, 2003, Jan-28, Volume: 107, Issue:3

    Topics: Adolescent; Adult; Aged; Allopurinol; Cross-Over Studies; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Humans; Male; Middle Aged; Nitric Oxide Synthase; omega-N-Methylarginine; Regional Blood Flow; Single-Blind Method; Smoking; Vasodilation; Xanthine Oxidase

2003
Allopurinol and nitric oxide activity in the cerebral circulation of those with diabetes: a randomized trial.
    Diabetes care, 2009, Volume: 32, Issue:1

    Topics: Allopurinol; Carotid Arteries; Cerebrovascular Circulation; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Double-Blind Method; Humans; Infusions, Intravenous; Male; Nitric Oxide; omega-N-Methylarginine; Placebos; Stroke

2009

Other Studies

21 other study(ies) available for omega-n-methylarginine and allopurinol

ArticleYear
Contribution of nitric oxide synthase to luminol-dependent chemiluminescence generated by phorbol-ester-activated Kupffer cells.
    The Biochemical journal, 1991, Oct-01, Volume: 279 ( Pt 1)

    Topics: Acridines; Amino Acid Oxidoreductases; Animals; Arginine; Catalase; Cell-Free System; In Vitro Techniques; Kupffer Cells; Luminescent Measurements; Luminol; Male; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Rats; Rats, Inbred Strains; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Xanthine; Xanthine Oxidase; Xanthines

1991
Inhibitors of free radical formation fail to attenuate direct beta-amyloid25-35 peptide-mediated neurotoxicity in rat hippocampal cultures.
    Journal of neuroscience research, 1994, Nov-01, Volume: 39, Issue:4

    Topics: Allopurinol; Alzheimer Disease; Amino Acid Oxidoreductases; Amyloid beta-Peptides; Animals; Arginine; Catalase; Cell Death; Cells, Cultured; Embryo, Mammalian; Free Radical Scavengers; Free Radicals; Hippocampus; Humans; Indomethacin; Masoprocol; Neurons; Neurotoxins; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Oxypurinol; Peptide Fragments; Quinacrine; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Xanthine Oxidase

1994
Enhancement of endothelium-dependent contraction of the canine coronary artery by UW solution.
    Transplantation, 1994, Dec-27, Volume: 58, Issue:12

    Topics: Acetylcholine; Adenosine; Allopurinol; Animals; Arginine; Cell Communication; Coronary Vessels; Dinoprost; Dogs; Endothelium, Vascular; Female; Glutathione; Hypoxia; Insulin; Isoproterenol; Male; Nitric Oxide; omega-N-Methylarginine; Organ Preservation; Organ Preservation Solutions; Potassium; Raffinose; Time Factors; Vasoconstriction; Vasodilation

1994
Endothelium-dependent contractions to oxygen-derived free radicals in the canine basilar artery.
    The American journal of physiology, 1993, Volume: 264, Issue:3 Pt 2

    Topics: Animals; Arginine; Basilar Artery; Cattle; Dogs; Endothelium, Vascular; Free Radicals; Hydrogen Peroxide; Indomethacin; Meclofenamic Acid; Muscle Contraction; Muscle, Smooth, Vascular; omega-N-Methylarginine; Oxygen; Prostaglandins; Superoxide Dismutase; Thromboxane B2; Xanthine; Xanthine Oxidase; Xanthines

1993
Induction of nitric oxide and nitric oxide synthase mRNA by silica and lipopolysaccharide in PMA-primed THP-1 cells.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 1996, Volume: 104, Issue:3

    Topics: Allopurinol; Antimetabolites; Arginine; Cycloheximide; Dactinomycin; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Humans; Leukemia, Monocytic, Acute; Lipopolysaccharides; Monocytes; Neoplasm Proteins; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Protein Synthesis Inhibitors; RNA, Messenger; Silicon Dioxide; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Xanthine Oxidase

1996
Studies on nitric oxide free radicals generated from polymorphonuclear leukocytes (PMN) stimulated by phorbol myristate acetate (PMA).
    Cell biology international, 1996, Volume: 20, Issue:5

    Topics: Arginine; Cyclic N-Oxides; Enzyme Inhibitors; Free Radicals; Humans; Luminescent Measurements; Luminol; Neutrophils; Nitric Oxide; omega-N-Methylarginine; Spin Labels; Tetradecanoylphorbol Acetate; Xanthine; Xanthine Oxidase; Xanthines

1996
Nitric oxide regulation of superoxide-dependent lung injury: oxidant-protective actions of endogenously produced and exogenously administered nitric oxide.
    Free radical biology & medicine, 1996, Volume: 21, Issue:1

    Topics: Animals; Cell Survival; Cells, Cultured; Cytokines; Epithelium; Escherichia coli; Fetus; Glutathione; Interferon-gamma; Interleukin-1; Kinetics; Lipopolysaccharides; Lung; Nitric Oxide; Nitroso Compounds; omega-N-Methylarginine; Oxidants; Oxygen; Penicillamine; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Superoxides; Time Factors; Tumor Necrosis Factor-alpha; Xanthine Oxidase; Zymosan

1996
NO synthase and xanthine oxidase activities of rabbit brain synaptosomes: peroxynitrite formation as a causative factor of neurotoxicity.
    Neurochemical research, 1996, Volume: 21, Issue:1

    Topics: Animals; Cell Survival; Cerebral Cortex; Enzyme Inhibitors; Membrane Fluidity; Neurons; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxidative Stress; Rabbits; Reactive Oxygen Species; Synaptosomes; Ultraviolet Rays; Xanthine Oxidase

1996
Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism.
    The American journal of physiology, 1996, Volume: 271, Issue:5 Pt 1

    Topics: Animals; Cell Transformation, Viral; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epithelium; Guinea Pigs; Humans; Hydrogen Peroxide; Molsidomine; Mucins; Nitric Oxide; omega-N-Methylarginine; Penicillamine; Peroxides; Reactive Oxygen Species; S-Nitroso-N-Acetylpenicillamine; Superoxides; tert-Butylhydroperoxide; Trachea; Type C Phospholipases; Xanthine Oxidase

1996
Altered endothelial and smooth muscle cell reactivity caused by University of Wisconsin preservation solution in human saphenous vein.
    Journal of vascular surgery, 1997, Volume: 25, Issue:4

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine; Allopurinol; Cardioplegic Solutions; Cold Temperature; Coronary Artery Bypass; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Hot Temperature; Humans; Insulin; Isotonic Solutions; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroprusside; Norepinephrine; omega-N-Methylarginine; Organ Preservation Solutions; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Raffinose; Saphenous Vein; Serotonin; Thromboxane A2; Tissue Preservation; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

1997
Induction of nitric oxide synthesis and xanthine oxidase and their roles in the antimicrobial mechanism against Salmonella typhimurium infection in mice.
    Infection and immunity, 1997, Volume: 65, Issue:7

    Topics: Allopurinol; Animals; Antimetabolites; Enzyme Inhibitors; Liver; Male; Mice; Mice, Inbred ICR; Nitric Oxide; omega-N-Methylarginine; Salmonella Infections, Animal; Salmonella typhimurium; Xanthine Oxidase

1997
Nitric oxide production in human macrophagic cells phagocytizing opsonized zymosan: direct characterization by measurement of the luminol dependent chemiluminescence.
    Free radical research, 1998, Volume: 28, Issue:2

    Topics: Calcitriol; Cell Differentiation; Cell-Free System; Free Radical Scavengers; Guanidines; Humans; Immunoglobulin E; Immunoglobulin G; Leukemia, Monocytic, Acute; Luminescent Measurements; Luminol; Lymphoma, Large B-Cell, Diffuse; Macrophage Activation; Macrophages; Neoplastic Stem Cells; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Opsonin Proteins; Phagocytosis; Superoxide Dismutase; Superoxides; Tretinoin; Tumor Cells, Cultured; Xanthine; Xanthine Oxidase; Zymosan

1998
The binding of oxidized low density lipoprotein (ox-LDL) to ox-LDL receptor-1 reduces the intracellular concentration of nitric oxide in endothelial cells through an increased production of superoxide.
    The Journal of biological chemistry, 2001, Apr-27, Volume: 276, Issue:17

    Topics: Allopurinol; Animals; Antibodies, Monoclonal; Antioxidants; Aorta; Ascorbic Acid; Aspirin; Bradykinin; Catecholamines; Cattle; Cells, Cultured; CHO Cells; Chromans; Cricetinae; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Flow Cytometry; Free Radical Scavengers; Hemostatics; Humans; Imidazolines; Lipoproteins, LDL; Mice; Nitric Oxide; omega-N-Methylarginine; Oxygen; Probucol; Protein Binding; Reactive Oxygen Species; Receptors, LDL; Receptors, Oxidized LDL; Scavenger Receptors, Class E; Superoxides; Thrombin; Time Factors

2001
Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart.
    Circulation research, 2002, Feb-22, Volume: 90, Issue:3

    Topics: Allopurinol; Animals; Antioxidants; Ascorbic Acid; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Dogs; Energy Metabolism; Fluorescent Antibody Technique; Free Radical Scavengers; Hemodynamics; Infusions, Intravenous; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; omega-N-Methylarginine; Signal Transduction; Xanthine Oxidase

2002
Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:8

    Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Animals; Cattle; Coronary Vasospasm; Coronary Vessels; Cytochrome P-450 Enzyme System; Endothelium, Vascular; In Vitro Techniques; Intramolecular Oxidoreductases; Lipopolysaccharides; Nitrates; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peroxynitrous Acid; Polyethylene Glycols; Prostaglandin Endoperoxides; Receptors, Thromboxane; Superoxide Dismutase; Superoxides; Vasoconstriction; Vasodilation; Xanthine Oxidase

2003
The inhibition of superoxide production in EL4 lymphoma cells overexpressing growth hormone.
    Immunopharmacology and immunotoxicology, 2003, Volume: 25, Issue:2

    Topics: Animals; Apoptosis; Blotting, Western; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Inhibitors; Flow Cytometry; Fluorometry; Growth Hormone; Isoniazid; Lymphoma, T-Cell; Mice; NADPH Oxidases; omega-N-Methylarginine; Superoxides; T-Lymphocytes; Tumor Cells, Cultured; Xanthine Oxidase

2003
Effect of high-salt diet on NO release and superoxide production in rat aorta.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 286, Issue:2

    Topics: Animals; Aorta; In Vitro Techniques; Male; Methacholine Chloride; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Superoxides; Xanthine Oxidase

2004
Amlodipine increases endothelial nitric oxide by dual mechanisms.
    Pharmacology, 2004, Volume: 70, Issue:1

    Topics: Amlodipine; Animals; Antioxidants; Aorta; Cells, Cultured; Coronary Vessels; Cyclic GMP; Endothelial Cells; Endothelium, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; omega-N-Methylarginine; Reactive Oxygen Species; Superoxides; Swine; Up-Regulation; Xanthine Oxidase

2004
Endothelium-dependent relaxation of canine pulmonary artery after prolonged lung graft preservation in University of Wisconsin solution: role of L-arginine supplementation.
    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2004, Volume: 23, Issue:5

    Topics: Acetylcholine; Adenosine; Adenosine Diphosphate; Allopurinol; Animals; Arginine; Dogs; Endothelium, Vascular; Female; Glutathione; Insulin; Lung; Lung Transplantation; Male; Molsidomine; omega-N-Methylarginine; Organ Preservation Solutions; Pulmonary Artery; Raffinose; Sodium Fluoride; Tissue Preservation

2004
Nitric oxide preserves the glomerular protein permeability barrier by antagonizing superoxide.
    Kidney international, 2005, Volume: 68, Issue:6

    Topics: Albumins; Animals; Antioxidants; Cyclic N-Oxides; Enzyme Inhibitors; Kidney Glomerulus; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroso Compounds; omega-N-Methylarginine; Permeability; Rats; Rats, Sprague-Dawley; Spin Labels; Superoxides; Tumor Necrosis Factor-alpha; Xanthine Oxidase

2005
Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase.
    Circulation research, 2008, Oct-24, Volume: 103, Issue:9

    Topics: Allopurinol; Animals; Aorta; Arginine; Cell Hypoxia; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Erythrocytes; Fluorometry; Humans; Hydrogen-Ion Concentration; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrite Reductases; Nitrites; omega-N-Methylarginine; Oxidation-Reduction; Rats; Rats, Wistar; Xanthine; Xanthine Dehydrogenase

2008