omega-conotoxin-(conus-magus) and selfotel

omega-conotoxin-(conus-magus) has been researched along with selfotel* in 1 studies

Other Studies

1 other study(ies) available for omega-conotoxin-(conus-magus) and selfotel

Article	Year
The role of P-type calcium channels in the depolarization-induced activation of nitric oxide synthase in frontal cortex. Journal of neurochemistry, 1994, Volume: 62, Issue:1 In this study we demonstrate that 50 mM K+ stimulates the conversion of L-[3H]arginine to L-[3H]citrulline and that this effect is blocked by 10 microM N omega-nitro-L-arginine, a nitric oxide synthase inhibitor, and Ca(2+)-free conditions. Amiloride (1 mM) and low Na+ conditions were used to test the possible involvement of the Na(+)-Ca2+ exchanger. These treatments were without effect. The calcium channel blockers 10 mM Mg2+, 100 microM Cd2+, and 10 mM Co2+ also blocked the K+ response, suggesting the involvement of voltage-dependent calcium channels (VDCCs). The specific VDCC involved seems to be the P type, as funnel-web spider toxin blocked the response whereas 200 microM Ni2+, 10 microM nifedipine, and 100 nM omega-conotoxin did not. Topics: Amiloride; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Calcium Channel Blockers; Calcium Channels; Carrier Proteins; Citrulline; Enzyme Activation; Frontal Lobe; In Vitro Techniques; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitroarginine; omega-Conotoxins; Peptides; Pipecolic Acids; Polyamines; Potassium; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger	1994

Article

Year

The role of P-type calcium channels in the depolarization-induced activation of nitric oxide synthase in frontal cortex.

Journal of neurochemistry, 1994, Volume: 62, Issue:1

In this study we demonstrate that 50 mM K+ stimulates the conversion of L-[3H]arginine to L-[3H]citrulline and that this effect is blocked by 10 microM N omega-nitro-L-arginine, a nitric oxide synthase inhibitor, and Ca(2+)-free conditions. Amiloride (1 mM) and low Na+ conditions were used to test the possible involvement of the Na(+)-Ca2+ exchanger. These treatments were without effect. The calcium channel blockers 10 mM Mg2+, 100 microM Cd2+, and 10 mM Co2+ also blocked the K+ response, suggesting the involvement of voltage-dependent calcium channels (VDCCs). The specific VDCC involved seems to be the P type, as funnel-web spider toxin blocked the response whereas 200 microM Ni2+, 10 microM nifedipine, and 100 nM omega-conotoxin did not.

Topics: Amiloride; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Calcium Channel Blockers; Calcium Channels; Carrier Proteins; Citrulline; Enzyme Activation; Frontal Lobe; In Vitro Techniques; Male; N-Methylaspartate; Nitric Oxide Synthase; Nitroarginine; omega-Conotoxins; Peptides; Pipecolic Acids; Polyamines; Potassium; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger

1994