omega-agatoxin-iva and 2-amino-4-phosphonobutyric-acid

omega-agatoxin-iva has been researched along with 2-amino-4-phosphonobutyric-acid* in 2 studies

Other Studies

2 other study(ies) available for omega-agatoxin-iva and 2-amino-4-phosphonobutyric-acid

Article	Year
PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7. The EMBO journal, 2002, Jun-17, Volume: 21, Issue:12 Both postsynaptic density and presynaptic active zone are structural matrix containing scaffolding proteins that are involved in the organization of the synapse. Little is known about the functional role of these proteins in the signaling of presynaptic receptors. Here we show that the interaction of the presynaptic metabotropic glutamate (mGlu) receptor subtype, mGlu7a, with the postsynaptic density-95 disc-large zona occludens 1 (PDZ) domain-containing protein, PICK1, is required for specific inhibition of P/Q-type Ca(2+) channels, in cultured cerebellar granule neurons. Furthermore, we show that activation of the presynaptic mGlu7a receptor inhibits synaptic transmission and this effect also requires the presence of PICK1. These results indicate that the scaffolding protein, PICK1, plays an essential role in the control of synaptic transmission by the mGlu7a receptor complex. Topics: Aminobutyrates; Animals; Calcium Channel Blockers; Calcium Channels, P-Type; Calcium Channels, Q-Type; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Mice; Mice, Knockout; Neurons; Nuclear Proteins; Oligonucleotides, Antisense; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate; Synaptic Transmission; Synaptophysin	2002
L-AP4 inhibition of depolarization-evoked cGMP formation in rat cerebellum. Neuroscience letters, 1997, Jun-13, Volume: 228, Issue:3 The effects of the group III mGluR agonist, L-2-amino-4-phosphonobutyrate (L-AP4), on depolarization-stimulated cGMP levels in adult rat cerebellar slices were determined. L-AP4 elicited a concentration-dependent, complete inhibition of cGMP formation stimulated by 4-aminopyridine (4-AP; 1 mM), yielding an IC50 value of 4.2 +/- 1.6 microM (n = 3). The 4-AP response was also reduced by the P-type Ca2+ channel toxins omega-conotoxin MVIIC (3 microM; 39 +/- 7% inhibition) and omega-Agatoxin IVA (30 nM; 53 +/- 4%), and was abolished in the absence of Ca2+ or in the presence of Co2+. The inhibitions of the 4-AP cGMP response by 10 microM L-AP4 and 30 nM omega-Agatoxin IVA were not additive, indicating that part of the actions of L-AP4 in the cerebellum involves the modulation of P-type Ca2+ channels. Topics: 4-Aminopyridine; Aminobutyrates; Animals; Calcium Channel Blockers; Cerebellum; CHO Cells; Cricetinae; Cyclic GMP; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Nitroprusside; omega-Agatoxin IVA; omega-Conotoxins; Peptides; Rats; Rats, Sprague-Dawley; Spider Venoms; Vasodilator Agents	1997

Article

Year

PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7.

The EMBO journal, 2002, Jun-17, Volume: 21, Issue:12

Both postsynaptic density and presynaptic active zone are structural matrix containing scaffolding proteins that are involved in the organization of the synapse. Little is known about the functional role of these proteins in the signaling of presynaptic receptors. Here we show that the interaction of the presynaptic metabotropic glutamate (mGlu) receptor subtype, mGlu7a, with the postsynaptic density-95 disc-large zona occludens 1 (PDZ) domain-containing protein, PICK1, is required for specific inhibition of P/Q-type Ca(2+) channels, in cultured cerebellar granule neurons. Furthermore, we show that activation of the presynaptic mGlu7a receptor inhibits synaptic transmission and this effect also requires the presence of PICK1. These results indicate that the scaffolding protein, PICK1, plays an essential role in the control of synaptic transmission by the mGlu7a receptor complex.

Topics: Aminobutyrates; Animals; Calcium Channel Blockers; Calcium Channels, P-Type; Calcium Channels, Q-Type; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Cerebellum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Mice; Mice, Knockout; Neurons; Nuclear Proteins; Oligonucleotides, Antisense; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate; Synaptic Transmission; Synaptophysin

2002

L-AP4 inhibition of depolarization-evoked cGMP formation in rat cerebellum.

Neuroscience letters, 1997, Jun-13, Volume: 228, Issue:3

The effects of the group III mGluR agonist, L-2-amino-4-phosphonobutyrate (L-AP4), on depolarization-stimulated cGMP levels in adult rat cerebellar slices were determined. L-AP4 elicited a concentration-dependent, complete inhibition of cGMP formation stimulated by 4-aminopyridine (4-AP; 1 mM), yielding an IC50 value of 4.2 +/- 1.6 microM (n = 3). The 4-AP response was also reduced by the P-type Ca2+ channel toxins omega-conotoxin MVIIC (3 microM; 39 +/- 7% inhibition) and omega-Agatoxin IVA (30 nM; 53 +/- 4%), and was abolished in the absence of Ca2+ or in the presence of Co2+. The inhibitions of the 4-AP cGMP response by 10 microM L-AP4 and 30 nM omega-Agatoxin IVA were not additive, indicating that part of the actions of L-AP4 in the cerebellum involves the modulation of P-type Ca2+ channels.

Topics: 4-Aminopyridine; Aminobutyrates; Animals; Calcium Channel Blockers; Cerebellum; CHO Cells; Cricetinae; Cyclic GMP; Excitatory Amino Acid Antagonists; In Vitro Techniques; Male; Nitroprusside; omega-Agatoxin IVA; omega-Conotoxins; Peptides; Rats; Rats, Sprague-Dawley; Spider Venoms; Vasodilator Agents

1997