oltipraz has been researched along with pyrazines in 322 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 48 (14.91) | 18.7374 |
| 1990's | 111 (34.47) | 18.2507 |
| 2000's | 125 (38.82) | 29.6817 |
| 2010's | 31 (9.63) | 24.3611 |
| 2020's | 7 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Curphey, T; Groopman, J; Helzlsouer, K; Kensler, T; Maxuitenko, Y; Roebuck, BD; Styczynski, P | 1 |
| Fleury, MB | 1 |
| Curphey, TJ; Eaton, DL; Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| Christensen, RG; Malone, W | 1 |
| Bennett, JL; Dimitrov, NV; Leece, CM; Malone, W; McMillan, J; Perloff, M | 1 |
| Nare, B; Prichard, RK; Smith, JM | 4 |
| Bouchard, L; Castonguay, A; Nicole, P; Pepin, P | 1 |
| Bennett, JL; Dimitrov, NV; McMillan, J | 1 |
| Groopman, JD; Kensler, TW; Liu, YL; Roebuck, BD; Rogers, AE | 1 |
| DeMatos, P; Egner, PA; Groopman, JD; Kensler, TW; Love-Hunt, A | 1 |
| abdel Gayoum, A; Ali, BH; el Gawarsha, K; Fakhri, M | 1 |
| Fleury, MB; Largeron, M; Martens, T | 1 |
| Nayini, J; Rao, CV; Reddy, BS | 1 |
| Davies, MH; Schamber, GJ; Schnell, RC | 1 |
| Davies, MH; Schnell, RC | 1 |
| Kelloff, G; Rao, CV; Reddy, BS; Tokomo, K | 1 |
| Bellora, E; Cereda, E; Donetti, A; Ezhayra, A; Monferini, E; Schiavone, A; Volontè, M | 1 |
| Aboul-Atta, AM | 1 |
| Aboul-Atta, AM; Awadallah, FE; el-Ahl, SS; Hamdy, BH; Hassan, ZA | 2 |
| Davidson, NE; Egner, PA; Kensler, TW | 1 |
| Mkoji, GM; Prichard, RK; Smith, JM | 2 |
| Fleury, MB; Leroy, JP; Martens, T; Moreau, N | 1 |
| Aboul-Atta, AM; el-Ahl, SS; Hassan, ZA | 3 |
| Aboul-Atta, AM; Zeedan, AH | 2 |
| Lawson, TW; Murray, WJ; Stohs, SJ; Wahba, ZZ | 1 |
| Dolan, PM; Egner, PA; Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| Ali, HM; Bennett, JL; Homeida, MM; Sulaiman, SM | 3 |
| Ali, HM; Bennet, JL; Homeida, MM; Sulaiman, SM | 1 |
| Charmot, G; Coulaud, JP; Marche, C; Penalba, C; Saimot, AG | 1 |
| Groopman, JD; Kensler, TW; Liu, YL; Roebuck, BD; Yager, JD | 1 |
| Daffalla, AA; el Tayeb, M; Fenwick, A; Kardaman, MW; See, R | 1 |
| Hu, YZ; Wang, GF; Yang, YQ; Zheng, H | 1 |
| Hassan, MM; Madwar, MA; Strickland, GT | 1 |
| Bruce, JI | 1 |
| Cornford, EM | 1 |
| Azoulay, M; Frappier, F; Leroy, JP | 1 |
| Bennett, JL; Morrison, DD; Semeyn, DR; Thompson, DP | 1 |
| Bueding, E; Wattenberg, LW | 1 |
| Ansher, SS; Bueding, E; Dolan, P | 1 |
| Bruce, JI; Coles, GC; Dias, EP; Katz, N; Kinoti, GK; Mutahi, WT | 1 |
| Anderson, L; Bueding, E; Lawson, TA; Stohs, SJ | 1 |
| Blacker, AM; Davies, MH; Schnell, RC | 1 |
| Archer, S | 1 |
| Daffalla, AA; Dixon, HG; el Igail, AB; el Tayeb, M; Fenwick, A; Kardaman, MW | 1 |
| Bennett, JL; Daffalla, AA; el Igail, AB; el Tayeb, M; Fenwick, A; Kardaman, MW | 1 |
| Bueding, E; Egner, PA; Groopman, JD; Kensler, TW; Trush, MA | 1 |
| Bieder, A; Bredenbac, J; Decouvelaere, B; Heusse, D; Jumeau, H; Leroy, JP; Marlard, M | 1 |
| Lawson, T; Stohs, S | 1 |
| Brücker, G; Danis, M; Duflo, B; Gentilini, M; Meunier, Y; Niel, G; Richard-Lenoble, D | 1 |
| Charmot, G; Mouchet, F; Rey, JL; Sellin, B; Sellin, E; Simonkovich, E | 1 |
| Baltes, R; Burchard, GD; Dietrich, M; Kern, P | 1 |
| Burchard, GD; Dietrich, M; Kern, P | 1 |
| Abaza, H; El-Kady, A; Wasfy, E | 1 |
| Ancelle, T; Dupouy-Camet, J; Faurant, C; Heyer, F; Keita, A; Lapierre, J; Tourte-Schaefer, C | 1 |
| Bieder, A; Decouvelaere, B; Depaire, H; Gaillard, C; Heusse, D; Le Roy, JP; Ledoux, C; Lemar, M; Raynaud, L; Snozzi, C | 1 |
| Ali, HM; Bennett, JL; Gaillot, J; Sulaiman, SM | 1 |
| Cavier, R | 1 |
| Ahmed, MA; Bella, H; Bennett, JL; Mustafa, MD; Rahim, AG; Wasfi, S | 1 |
| Bueding, E; Dolan, P; Leroy, JP | 1 |
| Breuil, J; Charmot, G; Coulanges, P; Moyroud, J | 1 |
| Breuil, J; Coulanges, P; Moyroud, J; Raveloarison, G | 1 |
| Basset, P; Grégoire, J; Lancastre, F; Lesobre, B; Mafart, Y; Meyniel, D; Piéron, R; Renard, A; Simon, J | 1 |
| Cerf, P; Coulanges, P; Moyroud, J | 1 |
| Buetler, TM; Eaton, DL; Gallagher, EP; Hayes, JD; Stahl, DL; Wang, C | 1 |
| Bornmann, WG; Chavan, SJ; Flexner, C; Prochaska, HJ | 1 |
| Clapper, ML; Engstrom, PF; Everley, LC; Strobel, LA; Townsend, AJ | 1 |
| Chavan, SJ; Prochaska, HJ | 1 |
| Baron, P; Bornmann, WG; Polsky, B; Prochaska, HJ | 1 |
| Clapper, ML; Lang, D; Leahy, K; Miknyoczki, S; Ruggeri, BA; Wood, M | 1 |
| Holt, PR; Liu, T; Mokuolu, AO; Rao, CV; Reddy, BS | 1 |
| Beaune, P; Becquemont, L; Coles, B; Guengerich, FP; Guillouzo, A; Ketterer, B; Langouët, S; Morel, F | 1 |
| Alberts, DS; Boone, CW; Covey, JM; Crowell, JA; Doody, LA; Greenwald, P; Kelloff, GJ; Knapp, GG; Lubet, RA; Steele, VE | 1 |
| Dolan, PM; Egner, PA; Gange, SJ; Groopman, JD; Kensler, TW; Muñoz, A | 1 |
| Egner, PA; Kelloff, GJ; Kensler, TW; Primiano, T; Roebuck, BD; Sutter, TR | 1 |
| Baron, P; Polsky, B; Prochaska, HJ; Yeh, Y | 1 |
| Kresty, LA; Morse, MA; Stoner, GD; Zu, H | 1 |
| O'Dwyer, PJ; Yao, KS | 2 |
| Feng, YM; Li, ZQ; Luo, XM; Wei, HJ; Zhang, C | 1 |
| Groopman, JD; Kensler, TW; Roebuck, BD | 1 |
| Baron, P; Polsky, B; Prochaska, HJ; Rubinson, L; Yeh, Y | 1 |
| Li, ZQ | 1 |
| Helzlsouer, KJ; Kensler, TW | 2 |
| Kensler, TW; MacMillan, DL; Maxuitenko, YY; Roebuck, BD | 1 |
| Curphey, TJ; Egner, PA; Joyner, HH; Kensler, TW; Libby, AH; Prestera, T; Talalay, P | 1 |
| Bolton, MG; Groopman, JD; Jacobson, LP; Kensler, TW; Maxuitenko, YY; Muñoz, A; Roebuck, BD | 1 |
| Benson, AB | 1 |
| Fardel, O; Gilmore, KS; Guillouzo, A; Kensler, TW; Ketterer, B; Langouet, S; Meunier, B; Meyer, DJ; Morel, F; Tu, CP | 1 |
| Abdel-Rahman, SZ; el-Kholy, Z; el-Sharkawy, A; el-Toukhy, M; el-Zoghby, S; Farag, H; Gaber, N | 1 |
| Coles, B; Gilmore, KS; Harris, JM; Kensler, TW; Ketterer, B; Meyer, DJ | 1 |
| Katiwalla, M; Kelloff, GJ; Rao, CV; Reddy, BS; Rivenson, A | 1 |
| Anderson, L; Kelloff, GJ; Sharma, S; Steele, VK | 1 |
| Baron, P; Chavan, SJ; Polsky, B; Prochaska, HJ | 1 |
| Ahmed, SA; Gad, MZ | 1 |
| Bammler, TK; Buetler, TM; Eaton, DL; Hayes, JD | 1 |
| Chavan, SJ; Fernandes, CL; Pantoja, RM; Prochaska, HJ | 1 |
| Ellis, EM; Hayes, JD; Judah, DJ; Neal, GE; O'Connor, T | 1 |
| Corcos, L; Fardel, O; Guillouzo, A; Ketterer, B; Langouët, S; Meyer, DJ; Morel, F | 1 |
| Groopman, JD; Kensler, TW; Musser, SM; Scholl, P | 1 |
| Jansen, JB; Peters, WH; van Lieshout, EM | 1 |
| Kelloff, G; Rao, CV; Reddy, BS; Rivenson, A; Steele, V; Zang, E | 1 |
| Balshem, AM; Brennan, J; Clapper, ML; Engstrom, PF; Frucht, H; Gallo, JM; Goosenberg, EB; Green, F; Halbherr, TC; Hamilton, TC; Litwin, S; O'Dwyer, PJ; Pfeiffer, GR; Szarka, CE; Yao, KS | 1 |
| Buiatti, E | 1 |
| Coles, B; Guillouzo, A; Ketterer, B; Langouet, S; Maheo, K; Morel, F | 1 |
| Fei, P; Kong, AN; Matwyshyn, GA; Rushmore, TH | 1 |
| Brenner, DE; Krishnan, K | 1 |
| Grove, AD; Kessler, FK; Metz, RP; Ritter, JK | 1 |
| Crowell, JA; Goldenthal, EI; Hall, LB; Heath, JE; Kelloff, GJ; Page, JG; Rodman, LE | 1 |
| Groopman, JD; Kensler, TW | 1 |
| Bagnasco, M; Bennicelli, C; Camoirano, A; De Flora, S; Kensler, TW; Qian, GS; van Zandwijk, N; Wigbout, G; Zhu, YR | 1 |
| de Sousa, G; Guillouzo, A; Langouët, S; Lorenzon, G; Nicolas, F; Placidi, M; Rahmani, R | 1 |
| Kessler, FK; Ritter, JK | 1 |
| Hamilton, TC; Johnson, SW; Khater, C; Krueger, A; Matsumoto, Y; O'Dwyer, PJ; Yao, KS | 1 |
| Gates, KS; Kim, W | 1 |
| Chen, B; Davidson, NE; Egner, PA; Enger, C; Fang, X; Gordon, GB; Gorman, MB; Groopman, JD; Helzlsouer, KJ; Jacobson, LP; Kensler, TW; Kuang, SY; Li, YF; Muñoz, A; Prochaska, HJ; Qian, GS; Wang, JB; Wu, Y; Yu, LY; Zarba, A; Zhang, BC; Zhang, QN; Zhu, YR | 1 |
| Cho, CK; Kim, JH; Kim, SG; Nam, SY; Yoo, SY | 1 |
| Antras-Ferry, J; Guillouzo, A; Langouët, S; Maheo, K; Morel, F | 1 |
| Cho, CK; Kim, CW; Kim, JH; Kim, SG; Nam, SY; Yoo, SY | 1 |
| Kensler, TW; Roebuck, BD; Rogers, AE | 1 |
| Berthou, F; Coles, B; Glaise, D; Guillouzo, A; Ketterer, B; Lagadic-Gossman, D; Langouët, S; Mahéo, K; Morel, F | 1 |
| Kensler, TW | 1 |
| Dolan, PM; Egner, PA; Gange, SJ; Groopman, JD; Kensler, TW; Muñoz, A; Roebuck, BD; Rogers, AE | 1 |
| Guillouzo, A; Langouët, S; Mahéo, K; Morel, F | 1 |
| Antras-Ferry, J; Chevanne, M; Cillard, J; Cillard, P; Dubos, MP; Guillouzo, A; Mahéo, K; Morel, F | 1 |
| Franklin, MR; Lamb, JG; Vargas, M | 1 |
| Chen, B; Davidson, NE; Egner, PA; Enger, C; Fang, X; Gordon, GB; Gorman, MB; He, X; Helzlsouer, KJ; Jacobson, LP; Kensler, TW; Kuang, SY; Li, YF; Muñoz, A; Otieno, M; Prochaska, HJ; Qian, GS; Wang, JB; Wang, JS; Wu, Y; Yu, LY; Zarba, A; Zhang, BC; Zhang, QN; Zhu, YR | 1 |
| Metz, RP; Ritter, JK | 1 |
| Furukawa, F; Ikezaki, S; Kasahara, K; Lee, IS; Nishikawa, A; Takahashi, M; Tanakamura, Z | 1 |
| Reddy, BS | 1 |
| Chen, B; Davidson, NE; De Flora, S; Egner, PA; Enger, CL; Fang, X; Gordon, GB; Gorman, MB; Groopman, JD; He, X; Jacobson, LP; Kensler, TW; Kuang, SY; Li, YF; Muñoz, A; Prochaska, HJ; Qian, GS; Wang, JB; Wang, JS; Wu, Y; Yu, LY; Zarba, A; Zhang, BC; Zhang, QN; Zhu, YR | 1 |
| Clapper, ML | 1 |
| Kim, CW; Kim, SG; Nam, SY | 1 |
| Clapper, ML; Szarka, CE | 1 |
| Arif, JM; Gairola, CG; Glauert, HP; Gupta, RC; Kelloff, GJ; Lubet, RA | 1 |
| Curphey, TJ; Joyner, HH; Kensler, TW; Libby, AH; MacMillan, DL; Maxuitenko, YY; Roebuck, BD | 1 |
| Clayton, M; Halbherr, T; Myers, CB; O'Dwyer, PJ; Yao, Ks | 1 |
| Baker, TM; Benson, AB; Berezin, FK; Dolan, ME; Gupta, E; Mick, R; Olopade, OI; Ratain, MJ | 1 |
| Choi, SH; Kim, SG | 1 |
| Antras-Ferry, J; Corcos, L; Desmots, F; Guillouzo, A; Langoüet, S; Mahéo, K; Morel, F | 1 |
| Carr, BA; Franklin, MR | 2 |
| Boone, CW; Chi, WJ; Doong, SL; Kelloff, GJ; Lin, JK; Lin-Shiau, SY | 1 |
| Curphey, TJ; Groopman, JD; Kensler, TW; Roebuck, BD; Sutter, TR | 1 |
| Egner, PA; Groopman, JD; He, X; Helzlsouer, KJ; Jacobson, LP; Kensler, TW; Kuang, SY; Muñoz, A; Qian, GS; Shen, X; Wang, JB; Wang, JS; Zarba, A; Zhang, BC; Zhu, YR | 1 |
| Cho, MK; Choi, SH; Kim, HJ; Kim, ND; Kim, SG; Kwak, MK | 1 |
| Courtois, A; Fardel, O; Guillouzo, A; Morel, F; Payen, L; Vernhet, L | 1 |
| Groopman, JD; Jackson, PE | 1 |
| Fink-Gremmels, J; Kuilman, ME; Maas, RF; Woutersen-van Nijnanten, FM | 1 |
| Bammler, TK; Eaton, DL; Slone, DH | 1 |
| Furge, LL; Guengerich, FP; Guillouzo, A; Kerriguy, N; Langouët, S; Nakamura, K | 1 |
| Furukawa, F; Hirose, M; Ikeda, T; Kasahara, KI; Miyauchi, M; Nakamura, H; Nishikawa, A; Son, HY | 1 |
| Brenner, DE; Krishnan, K; Ruffin, MT | 1 |
| Egner, PA; Groopman, JD; Kensler, TW; Li, Y; Qin, L; Roebuck, BD; Su, J; Wang, J | 1 |
| Alaoui-Jamali, MA; Batist, G; Fotouhi-Ardakani, N; Jaitovitch-Groisman, I; Schecter, RL; Woo, A | 1 |
| Franklin, MR; Lamb, JG | 2 |
| Benson, AB; Dolan, ME; French, S; Mobarhan, S; Olopade, OI; Rademaker, A; Ratain, MJ; Stucky-Marshall, L | 1 |
| Ali, IU; Herbert, BS; Kopelovich, L; Passons, CM; Shay, JW; Wright, AC; Wright, WE | 1 |
| Arif, JM; Gupta, RC; Smith, WA | 1 |
| Brennan, JM; Gallo, JM; Laub, PB; O'Dwyer, PJ; Szarka, C | 1 |
| Bardiau, C; Courtois, A; Guillouzo, A; Ilyin, G; Le Ferrec, E; Mahéo, K; Morel, F | 1 |
| Dolan, PM; Itoh, K; Kensler, TW; Kwak, MK; Ramos-Gomez, M; Talalay, P; Yamamoto, M | 1 |
| Balansky, RM; Bennicelli, C; Dagostini, F; De Flora, S; Grubbs, CJ; Izzotti, A; Kelloff, GJ; Lubet, RA; Myers, SR | 1 |
| Bennett, JL; Bennink, M; Crowell, J; Dimitrov, NV; Gardiner, J; Hawk, E; Leece, CM; Nashawaty, M; Seymour, E; Tompkins, ER | 1 |
| Bolanowska-Higdon, W; Creaven, PJ; Hitt, S; Lawrence, D; Murphy, M; Pendyala, L; Schwartz, G; Zdanowicz, J | 1 |
| Camoirano, A; Cartiglia, C; De Flora, S; Izzotti, A; Tampa, E | 1 |
| Auyeung, DJ; Kessler, FK; Ritter, JK | 2 |
| Bagnasco, M; Bennicelli, C; Camoirano, A; Cartiglia, C; De Flora, S; Egner, PA; Jacobson, LP; Kensler, TW; Qian, GS; Wang, JB; Zhang, BC; Zhu, YR | 1 |
| Egner, P; Groopman, JD; Kensler, TW; Scholl, PF; Walker, J; Walton, M | 1 |
| Choo, EF; Mayo, G; Shyr, Y; Sofowora, GG; Wilkinson, GR | 1 |
| Freeman, JW; Gupta, RC; Smith, WA | 1 |
| Dolan, PM; Egner, PA; Groopman, JD; Itoh, K; Kensler, TW; Kwak, MK; Ramos-Gomez, M; Yamamoto, M | 1 |
| Carey, KA; Fishbein, JC; Kensler, TW | 1 |
| Balshem, AM; Clapper, ML; Engstrom, PF; Frucht, H; Goosenberg, EB; Litwin, S; O'Dwyer, PJ; Pfeiffer, GR; Szarka, CE; Yao, KS | 1 |
| Angeles, T; Clapper, ML; Robinson, C; Ruggeri, BA; Wilkinson, J | 1 |
| Choi, SH; Ha, JR; Kang, KW; Kim, CW; Kim, SG | 1 |
| Auyeung, DJ; Kessler, FK; Kessler, MR; Ritter, JK | 1 |
| Bai, H; Chen, F; Hu, G; Luo, X; Wei, H; Zhu, M | 1 |
| Bardiau, C; Guillouzo, A; Lagadic-Gossmann, D; Le Ferrec, E; Le Vee, M; Maheo, K; Massiere, F; Morel, F; Rauch, C | 1 |
| Fautrel, A; Guillouzo, A; Langouët, S; Salles, B; Sparfel, L | 1 |
| Biswas, S; Das, SK; Gairola, CG | 1 |
| Bae, SK; Cho, MK; Kang, KW; Kim, CW; Kim, SG; Kim, YG; Lee, MG | 1 |
| Armstrong, JS; Cai, J; Jones, DP; Moriarty, S; Nelson, KC; Sternberg, P; Wu, MW | 1 |
| Kang, KW; Kim, CW; Kim, SG; Kim, YG | 1 |
| Chan, JY; Pietsch, EC; Torti, FM; Torti, SV | 1 |
| Contreras, ML; Crowell, J; Dimitrov, NV; Madhukar, BV; Meyer-Leece, C | 1 |
| Batist, G; Fotouhi-Ardakani, N; Hamilton, D | 1 |
| Blans, P; Fishbein, JC; McGrath, C; Navamal, M; Stewart, J; Villamena, F; Zweier, J | 1 |
| Bai, H | 1 |
| Cho, IJ; Kang, KW; Kim, SG; Lee, CH | 1 |
| Egner, PA; Gange, SJ; Groopman, JD; Jacobson, LP; Kensler, TW; Kuang, SY; Muñoz, A; Qian, GS; Wang, JB; Zhang, BC; Zhu, YR | 1 |
| Dolan, PM; Itoh, K; Kensler, TW; Ramos-Gomez, M; Yamamoto, M | 1 |
| Sudakin, DL | 1 |
| Dai, G; Wang, X | 1 |
| Begleiter, A; Bird, RP; Curphey, TJ; Sivananthan, K | 1 |
| Batist, G; Hu, L; Kandouz, M; Miao, W | 1 |
| Bu, SC; Kim, EJ; Kim, SG; Kim, SH; Lee, MG | 1 |
| Cherrington, NJ; Klaassen, CD; Maher, JM; Slitt, AL | 1 |
| Cho, IJ; Kim, SG | 1 |
| Baumgartner, KJ; Bodreddigari, S; Curphey, TJ; Gange, SJ; Kensler, TW; Li, Y; Roebuck, BD; Sutter, TR; Yan, J | 1 |
| Bae, SK; Chung, SJ; Kim, EJ; Kim, SG; Lee, MG | 1 |
| Fishbein, JC; Johnson, JK; Kensler, TW; Kwak, MK; Navamal, M; Petzer, JP | 1 |
| Fields, PR; Furge, LL; Goode, WE; Konwinski, RR; Stevens-Truss, R; Tressler, MC | 1 |
| Nho, CW; O'Dwyer, PJ | 1 |
| Abdel-Hamid, MA; El-Bassiouni, EA; Helmy, MH; Ismail, SS; Shohayeb, MA | 1 |
| Bae, SK; Kim, SG; Lee, I; Lee, JY; Lee, MG; Lee, SJ; Lee, Y | 1 |
| Cho, IJ; Kim, SG; Park, IN | 2 |
| Boone, CW; Christov, KT; Kelloff, GJ; Lantvit, DD; Lubet, RA; Moon, RC; Pezzuto, JM; Steele, VE | 1 |
| Bae, SK; Kim, JW; Kim, SG; Kim, YH; Lee, MG; Lee, SJ | 2 |
| Akaza, H; Hattori, K; Iida, K; Itoh, K; Kawai, K; Kumagai, Y; Oyasu, R; Shimazui, T; Yamamoto, M | 1 |
| Chun, JA; Furge, LL; Haab, BB; Haddad, R; Klenow, S; Konwinski, RR; Larson, SC | 1 |
| Guillouzo, A; Langouët, S; Le Ferrec, E; Le Goff, F; Morel, F; Petit, E; Piton, A; Rauch, C | 1 |
| Fishbein, JC; Velayutham, M; Villamena, FA; Zweier, JL | 1 |
| Bae, SK; Kim, JW; Kim, SH; Kim, T; Kim, YG; Lee, MG; Lee, SJ | 1 |
| Bae, SK; Kim, JW; Kim, SG; Kim, YG; Kim, YH; Lee, MG | 1 |
| Chu, H; Kensler, TW; Muñoz, A | 1 |
| Becker, F; Bergan, RC; Bhagat, R; Carmella, SG; Crowell, JA; Folz, RJ; Gallot, L; Glaser, EM; Hecht, SS; Herndon, JE; Kelley, MJ; Perloff, M; Santella, RM; Schilder, L; Zhang, YJ | 1 |
| Bae, SK; Kim, T; Kim, YH; Lee, MG; Lee, SJ | 1 |
| Ebert, B; Lampen, A; Seidel, A | 2 |
| Bae, SK; Kim, JW; Kim, T; Kwon, JW; Lee, MG; Yang, SH | 1 |
| Bae, EJ; Kim, SG | 1 |
| Fishbein, JC; Navamal, M; Velayutham, M; Villamena, FA; Zweier, JL | 1 |
| Armstrong, JS; Boelsterli, U; Chua, YL; Moore, PK; Whiteman, M; Zhang, D | 1 |
| Kim, SG; Lee, SJ | 1 |
| Bae, SK; Kim, JW; Kim, JY; Kim, T; Lee, MG; Yang, SH | 1 |
| Delude, RL; Englert, JA; Fink, MP; Han, Y; Kellum, JA; Killeen, ME; Song, M; Stolz, DB | 1 |
| Chu, H; Cole, SR; Nie, L | 2 |
| Li, J; Munday, CM; Munday, R; Zhang, Y | 1 |
| Bae, SK; Kang, HE; Kang, MK; Kim, JW; Kim, T; Lee, MG | 1 |
| Bae, SK; Kim, JW; Kim, SG; Kim, T; Lee, I; Lee, MG; Lee, SJ | 1 |
| Gao, P; Sharma, S; Steele, VE | 1 |
| Kim, JW; Kim, SG; Ko, MS; Lee, SJ; Lim, JW | 1 |
| Aldeghi, A; Emanuele, E; Martinelli, V; Olivieri, V | 1 |
| Boursier-Neyret, C; Fardel, O; Jigorel, E; Le Vee, M; Parmentier, Y | 1 |
| Dale, Y; Eltom, SE | 1 |
| Glintborg, B; Kensler, TW; Poulsen, HE; Weimann, A | 1 |
| Bhat, GJ; Niture, SK; Smith, QR; Srivenugopal, KS; Velu, CS | 1 |
| Farombi, EO; Surh, YJ | 1 |
| Cho, IJ; Kim, SG; Kim, SH | 1 |
| Gharibzadeh, S; Hoseini, SS; Mahdavi, S | 1 |
| Aleksunes, LM; Chan, JY; Chen, Y; Dalton, TP; Dieter, MZ; Guo, G; Klaassen, CD; Maher, JM; Manautou, JE; Scheffer, GL; Slitt, AL; Tanaka, Y; Yamamoto, M | 1 |
| Bae, EJ; Kim, JW; Kim, SG; Yang, YM | 1 |
| Kensler, TW; Yates, MS | 1 |
| Fishbein, JC; McCraken, J; Muthukumaran, RB; Sostaric, JZ; Velayutham, M; Zweier, JL | 1 |
| Chapple, S; Collins, C; Fairman, DA | 1 |
| Kim, JW; Lee, DY; Lee, MG | 1 |
| Beilke, LD; Besselsen, DG; Cheng, Q; Cherrington, NJ; Kulkarni, S; Slitt, AL | 1 |
| Chu, H; Kensler, TW; Nie, L | 1 |
| Bae, EJ; Kim, SG; Yang, YM | 1 |
| Augustine, LM; Cherrington, NJ; Fisher, CD; Huang, W; Jackson, JP; Klaassen, CD; Maher, JM; Merrell, MD; Moore, DD; Slitt, AL; Zhang, Y | 1 |
| Kim, SG; Shin, SM | 1 |
| Munday, R; Zhang, Y | 1 |
| George, EO; Goodwin, SB; Jin, VX; Kensler, TW; Phan, V; Rahman, M; Roebuck, BD; Sutter, CH; Sutter, TR; Tran, QT; Xu, L | 1 |
| Childers, A; Itoh, K; Kleiner, HE; Li, Y; Prince, M; Yamamoto, M | 1 |
| Ahn, CY; Bae, SH; Bae, SK; Jung, YS; Kim, T; Kim, YC; Lee, MG; Shin, WG | 1 |
| Brooks, C; Cho, IJ; Ki, SH; Kim, SG | 1 |
| Cho, IJ; Kim, SG; Kwon, YN; Shin, SM | 1 |
| Bae, EJ; Hwahng, SH; Ki, SH; Kim, HE; Kim, SG | 1 |
| Kang, KW | 1 |
| Cho, IJ; Kang, KW; Kim, SG; Sung, DK | 1 |
| Begleiter, A; Bird, RP; Lefas, GM; Maksymiuk, AW; Sivananthan, K | 1 |
| Aleksunes, LM; Beilke, LD; Besselsen, DG; Cherrington, NJ; Dvorak, K; Klaassen, CD; Olson, ER | 1 |
| Bae, SK; Kang, MK; Kim, JW; Lee, MG | 1 |
| Brooks, JS; Brooks, SC; Kim, SG; Lee, MG; Lee, WH | 1 |
| Fishbein, JC; Holland, R; Kensler, TW; Navamal, M; Velayutham, M; Zweier, JL | 1 |
| Brooks, SC; Choi, JH; Kim, SG; Kim, YW; Lee, MO; Lee, WH | 1 |
| Morsy, GH | 1 |
| Boyer, JL; Cai, SY; Soroka, CJ; Weerachayaphorn, J | 1 |
| Guillouzo, A; Langouet, S; Morel, F; Piton, A; Rauch, C | 1 |
| Calin, GA; Cartiglia, C; Croce, CM; De Flora, S; Izzotti, A; Longobardi, M; Steele, VE | 1 |
| Aleksunes, LM; Goedken, MJ; Klaassen, CD; Reisman, SA; Yeager, RL | 1 |
| Choi, SH; Kim, SG; Kim, YM; Lee, JM | 1 |
| Boyer, JL; Cai, SY; Soroka, CJ; Weerachayaphorn, J; Xu, S | 1 |
| Bhattacharyya, S; Gates, KS; Seiner, DR; Zhou, H | 1 |
| Cho, SH; Choi, JY; Choi, YH; Chon, CY; Han, JY; Jang, JJ; Jang, JW; Kim, SG; Kim, YM; Lee, DH; Lee, MG; Lee, YS; Um, SH; Yu, ES | 1 |
| Chiang, Y; Fantus, IG; Foltz, W; Jin, T; Ling, W; Shao, W; Yu, Z; Zhang, Z | 1 |
| Cho, SH; Choi, JY; Chon, CY; Han, JY; Jang, JJ; Jang, JW; Kim, SG; Kim, YM; Lee, DH; Lee, YS; Um, SH; Yu, E | 1 |
| Jin, QR; Kim, CY; Kim, DG; Lee, GW; Lee, JH; Lee, KR; Lim, H; Noh, HJ; Park, DH; Woo, YA | 1 |
| Kang, SG; Kim, SG; Lee, WH; Lee, YH; Lee, YS | 1 |
| Longford, NT | 1 |
| Aqil, F; Bansal, SS; Gupta, RC; Jeyabalan, J; Kausar, H; Sharma, RJ; Singh, IP; Vadhanam, MV | 1 |
| Eom, JS; Kim, SG; Kim, TH; Lee, CG; Lee, YS; Yang, YM | 1 |
| Eba, S; Hoshikawa, Y; Ishida, K; Kondo, T; Mitsuishi, Y; Moriguchi, T; Okada, Y; Satoh, H; Shimizu, T; Shimokawa, H; Watanabe, T; Yamamoto, M | 1 |
| Boyer, JL; Harry, K; Luo, Y; Mennone, A; Soroka, CJ; Weerachayaphorn, J | 1 |
| Fickert, P | 1 |
| Abdo, S; Chan, JS; Chenier, I; Filep, JG; Ghosh, A; Ingelfinger, JR; Lo, CS; Otoukesh, A; Shi, Y; Zhang, SL | 1 |
| Droździk, A; Laszczyńska, M; Wajda, A; Łapczuk, J | 1 |
| Amslinger, S; Rücker, H | 1 |
| Carew, MW; Charrois, GJ; Douglas, DN; Kneteman, NM; Le, XC; Leslie, EM; Lu, X; Roggenbeck, BA | 1 |
| Kim, SG; Lee, JM; Lee, YH; Lee, YS | 1 |
| Bao, K; Li, M; Lu, G; Qi, H; Shen, Q; Wang, Z; Wu, Y; Zhang, W | 1 |
| Averill-Bates, DA; Glory, A | 1 |
| Chang, MS; Cho, JY; Kim, BG; Kim, H; Kim, JH; Kim, SG; Kim, W; Kim, YJ; Lee, CK; Lee, J; Lee, JH; Lee, JS; Yeon, JE; Yi, S | 1 |
| Lin, J; Wang, SY | 1 |
| Kim, W; Kim, YJ | 1 |
| Droździk, M; Kurzawski, M; Machaliński, B; Niedzielski, A; Pius-Sadowska, E; Wajda, A; Łapczuk-Romańska, J | 1 |
| Guo, M; Hao, MH; Ma, XY; Sun, WP; Tang, Y; Zhu, HY | 1 |
| Cao, W; Chen, W; Ding, M; Guo, H; Lin, T; Wang, T; Wei, H; Yu, H; Zhang, C; Zhao, S; Zhao, X | 1 |
| Chang, Y; Hao, B; Li, C; Li, R; Li, Y; Liu, F; Ma, X; Muhammad, I; Shi, C; Wang, F; Yang, Y; Zhang, Y | 1 |
| Ali, M; Bonay, M; Deramaudt, TB; Vanhee, V; Vinit, S | 1 |
| Bian, M; Ding, L; Jiang, Z; Li, D; Wu, J; Zeng, Q | 1 |
| Lou, H; Ma, J; Shen, X; Sun, Q; Zhang, Q | 1 |
| An, H; An, X; Chen, Y; Dai, X; Guan, S; Huang, B; Huang, Q; Liang, L; Lu, M; Lu, X; Nie, H; Wang, H; Wang, J; Wang, Z; Zhang, H | 1 |
| Hao, S; Ishfaq, M; Li, C; Li, R; Liu, F; Ma, B; Shi, C; Wang, J; Yuan, L; Zhang, R; Zhang, Y | 1 |
| Acar, E; Altunrende, F; Can, O; Canat, L; Eraldemir, FC; Otunctemur, A; Sonmez, K; Yildirim, F | 1 |
| Kapoor-Narula, U; Lenka, N | 1 |
31 review(s) available for oltipraz and pyrazines
| Article | Year |
|---|---|
Mechanisms of chemoprotection by oltipraz.
Topics: Animals; Anticarcinogenic Agents; Disease Models, Animal; Humans; Pyrazines; Thiones; Thiophenes | 1992 |
New anthelmintics.
Topics: Albendazole; Animals; Anthelmintics; Benzimidazoles; Diphenylamine; Helminthiasis; Humans; Isothiocyanates; Ivermectin; Pyrazines; Schistosomicides; Thiocyanates; Thiones; Thiophenes | 1987 |
The chemotherapy of schistosomiasis.
Topics: Animals; Chemical Phenomena; Chemistry; Diphenylamine; Humans; Hycanthone; Isothiocyanates; Niridazole; Oxamniquine; Praziquantel; Pyrazines; Schistosomiasis; Schistosomicides; Thiocyanates; Thiones; Thiophenes; Trichlorfon | 1985 |
Carcinogen-DNA and protein adducts as intermediate biomarkers for human chemoprotection trials.
Topics: Aflatoxins; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; DNA; Humans; Liver Neoplasms, Experimental; Neoplasms; Proteins; Pyrazines; Thiones; Thiophenes | 1994 |
Cancer chemoprotection by oltipraz: experimental and clinical considerations.
Topics: Animals; Anticarcinogenic Agents; Clinical Trials as Topic; Drug Screening Assays, Antitumor; Female; Humans; Male; Neoplasms; Neoplasms, Experimental; Pyrazines; Thiones; Thiophenes | 1993 |
Oltipraz: a laboratory and clinical review.
Topics: Animals; Anticarcinogenic Agents; Humans; Pyrazines; Thiones; Thiophenes | 1993 |
Oltipraz: clinical opportunities for cancer chemoprevention. p.
Topics: Animals; Anticarcinogenic Agents; Clinical Trials as Topic; Disease Models, Animal; Evaluation Studies as Topic; Humans; Liver Neoplasms; Pyrazines; Risk Factors; Schistosomicides; Thiones; Thiophenes | 1995 |
Effects of oltipraz and related chemoprevention compounds on gene expression in rat liver.
Topics: Amino Acid Sequence; Animals; Anticarcinogenic Agents; Biomarkers; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Neoplastic; Liver; Molecular Sequence Data; Pyrazines; Rats; Thiones; Thiophenes | 1995 |
Oltipraz, a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) replication.
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Antiviral Agents; Clinical Trials as Topic; HIV-1; Humans; Pyrazines; Schistosomicides; Thiones; Thiophenes; Virus Replication | 1995 |
Chemoprevention of primary liver cancer.
Topics: Anticarcinogenic Agents; Cancer Vaccines; Carcinoma, Hepatocellular; Chemoprevention; Humans; Liver Neoplasms; Nutritional Physiological Phenomena; Pyrazines; Thiones; Thiophenes | 1996 |
Chemoprevention of colorectal cancer.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Calcium; Colorectal Neoplasms; Eflornithine; Ellagic Acid; Humans; Pyrazines; Thiones; Thiophenes | 1996 |
Carcinogen-DNA and protein adducts: biomarkers for cohort selection and modifiable endpoints in chemoprevention trials.
Topics: Aflatoxin B1; Aflatoxins; Aged; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Clinical Trials as Topic; Cohort Studies; DNA Adducts; Guanine; Hepatitis B; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Proteins; Pyrazines; Risk Factors; Thiones; Thiophenes | 1996 |
Chemoprevention by inducers of carcinogen detoxication enzymes.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Enzyme Induction; Humans; Liver Neoplasms; Pyrazines; Rats; Thiones; Thiophenes | 1997 |
The use of primary hepatocyte cultures for the evaluation of chemoprotective agents.
Topics: Animals; Anticarcinogenic Agents; Carcinogenicity Tests; Cells, Cultured; Humans; Isothiocyanates; Liver; Pyrazines; Rats; Sulfoxides; Thiocyanates; Thiones; Thiophenes; Toxicity Tests | 1997 |
Chemoprevention of colon cancer by dietary administration of naturally-occurring and related synthetic agents.
Topics: Allyl Compounds; Anethole Trithione; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Arachidonic Acids; Aspirin; Colon; Colonic Neoplasms; Dinoprostone; Disulfides; Eflornithine; Food, Fortified; Ibuprofen; Intestinal Mucosa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Piroxicam; Pyrazines; Thiones; Thiophenes | 1997 |
Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; China; Disease Models, Animal; Double-Blind Method; Humans; Liver Neoplasms; Placebos; Pyrazines; Rats; Thiones; Thiophenes; Treatment Outcome | 1997 |
Chemopreventive activity of oltipraz.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Biological Availability; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione Transferase; Humans; NAD(P)H Dehydrogenase (Quinone); Pyrazines; Reverse Transcriptase Inhibitors; Schistosomicides; Thiones; Thiophenes; Tissue Distribution | 1998 |
Glutathione S-transferases--biomarkers of cancer risk and chemopreventive response.
Topics: Animals; Anticarcinogenic Agents; Biomarkers; Brassica; Colitis, Ulcerative; Colorectal Neoplasms; Disease Models, Animal; Enzyme Induction; Gene Expression; Glutathione Transferase; Humans; Inactivation, Metabolic; Mice; Neoplasms; Pyrazines; Risk Factors; Thiones; Thiophenes | 1998 |
Development of cancer chemopreventive agents: oltipraz as a paradigm.
Topics: Animals; Anticarcinogenic Agents; Chemoprevention; Cytochrome P-450 Enzyme System; Drug Approval; Enzyme Induction; Humans; Neoplasms; Pyrazines; Thiones; Thiophenes | 1999 |
Aflatoxin and liver cancer.
Topics: Aflatoxins; Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; China; Environmental Exposure; Genes, p53; Humans; Incidence; Liver Neoplasms; Mutation; Pyrazines; Thiones; Thiophenes | 1999 |
Chemoprevention for colorectal cancer.
Topics: Adenoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antioxidants; Apoptosis; Arachidonic Acids; Bile Acids and Salts; Biomarkers; Calcium; Cell Cycle; Cell Transformation, Neoplastic; Clinical Trials as Topic; Colonic Polyps; Colorectal Neoplasms; DNA Methylation; DNA Repair; Eflornithine; Enzyme Inhibitors; Estrogens; Free Radical Scavengers; Genetic Predisposition to Disease; Humans; Mice; Ornithine Decarboxylase Inhibitors; Patient Compliance; Patient Selection; Polyamines; Precancerous Conditions; Pyrazines; Rats; Retinoids; Thiones; Thiophenes; Tumor Cells, Cultured; Vitamins | 2000 |
Role of phase 2 enzyme induction in chemoprotection by dithiolethiones.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Carcinogens; Chemoprevention; China; Controlled Clinical Trials as Topic; Enzyme Induction; Gene Expression; Glucuronosyltransferase; Glutathione Transferase; Humans; Inactivation, Metabolic; Liver Neoplasms; Pyrazines; Quinone Reductases; Thiones; Thiophenes | 2001 |
The glutathione system in alkylator resistance.
Topics: Alkylating Agents; Anticarcinogenic Agents; Buthionine Sulfoximine; Enzyme Inhibitors; Ethacrynic Acid; Glutamate-Cysteine Ligase; Glutathione; Glutathione Synthase; Humans; Neoplasms; Pyrazines; Thiones; Thiophenes | 2002 |
Strategies for chemoprevention of liver cancer.
Topics: Anticarcinogenic Agents; Carcinoma, Hepatocellular; Chemoprevention; Chlorophyllides; Clinical Trials as Topic; Female; Forecasting; Humans; Liver Neoplasms; Male; Primary Prevention; Prognosis; Pyrazines; Risk Assessment; Thiones; Thiophenes | 2002 |
Dietary aflatoxin exposure and chemoprevention of cancer: a clinical review.
Topics: Aflatoxins; Animals; Anticarcinogenic Agents; Biomarkers; Chlorophyllides; Diet; Humans; Neoplasms; Pyrazines; Reverse Transcriptase Inhibitors; Thiones; Thiophenes | 2003 |
[Development of bladder cancer chemoprevention].
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Papillary; Humans; Neoplasm Recurrence, Local; Piroxicam; Pyrazines; Retinoids; Thiones; Thiophenes; Urinary Bladder Neoplasms | 2003 |
Heme oxygenase-1 as a potential therapeutic target for hepatoprotection.
Topics: Anesthetics; Animals; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Enzyme Induction; Garlic; Heme Oxygenase-1; Humans; Liver; Liver Diseases; Metals, Heavy; Pyrazines; Signal Transduction; Thiones; Thiophenes | 2006 |
Keap1 eye on the target: chemoprevention of liver cancer.
Topics: Aflatoxins; Animals; Anticarcinogenic Agents; Antioxidants; Carcinoma, Hepatocellular; Clinical Trials as Topic; Humans; Intracellular Signaling Peptides and Proteins; Isothiocyanates; Kelch-Like ECH-Associated Protein 1; Liver Neoplasms; NF-E2-Related Factor 2; Phenols; Pyrazines; Signal Transduction; Sulfoxides; Thiocyanates; Thiones; Thiophenes; Triterpenes | 2007 |
Dithiolethiones for cancer chemoprevention: where do we stand?
Topics: Animals; Anticarcinogenic Agents; Chemoprevention; Humans; Models, Biological; Neoplasms; Pyrazines; Thiones; Thiophenes | 2008 |
Therapeutic potential of dithiolethiones for hepatic diseases.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Fatty Liver; Glutathione Transferase; Humans; Inactivation, Metabolic; Insulin Resistance; Liver; Liver Cirrhosis; Liver Diseases; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Protein Kinases; Pyrazines; Receptors, Aryl Hydrocarbon; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Thiones; Thiophenes; TOR Serine-Threonine Kinases | 2009 |
Antioxidant and mitochondrial protective effects of oxidized metabolites of oltipraz.
Topics: AMP-Activated Protein Kinases; Animals; Anticarcinogenic Agents; Antioxidants; Cell Survival; Cytoprotection; Humans; Mitochondria; Pyrazines; Reactive Oxygen Species; Thiones; Thiophenes | 2010 |
24 trial(s) available for oltipraz and pyrazines
| Article | Year |
|---|---|
Praziquantel and oltipraz: the treatment of schoolchildren infected with Schistosoma mansoni and/or Schistosoma haematobium in Gezira, Sudan.
Topics: Child; Female; Humans; Male; Parasite Egg Count; Praziquantel; Pyrazines; Random Allocation; Recurrence; Schistosomiasis haematobia; Schistosomiasis mansoni; Schistosomicides; Sex Factors; Sudan; Thiones; Thiophenes | 1988 |
Dose-finding trial using Oltipraz to treat schoolchildren infected with Schistosoma mansoni in Gezira, Sudan.
Topics: Abdomen; Administration, Oral; Child; Clinical Trials as Topic; Feces; Fingers; Follow-Up Studies; Humans; Pain; Parasite Egg Count; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Vision Disorders | 1985 |
Field trials with Oltipraz against Schistosoma mansoni in the Gezira Irrigated Area, Sudan.
Topics: Child; Clinical Trials as Topic; Dose-Response Relationship, Drug; Feces; Humans; Parasite Egg Count; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Sudan; Thiones; Thiophenes | 1985 |
Comparative trial of oltipraz versus praziquantel in the treatment of urinary schistosomiasis in the Gabon.
Topics: Adolescent; Child; Female; Gabon; Humans; Isoquinolines; Male; Parasite Egg Count; Praziquantel; Pyrazines; Schistosoma; Schistosoma haematobium; Schistosomiasis; Schistosomicides; Species Specificity; Thiones; Thiophenes; Urine; Urologic Diseases | 1984 |
Comparative study of oltipraz versus praziquantel for treatment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and S. haematobium).
Topics: Adolescent; Child; Child, Preschool; Feces; Female; Gabon; Humans; Intestinal Diseases, Parasitic; Isoquinolines; Male; Parasite Egg Count; Praziquantel; Pyrazines; Schistosoma; Schistosoma haematobium; Schistosomiasis; Schistosomicides; Species Specificity; Thiones; Thiophenes | 1984 |
Diet-controlled blood levels of oltipraz in healthy male subjects.
Topics: Adult; Biological Availability; Diet; Dietary Fats; Fasting; Humans; Kinetics; Male; Pyrazines; Schistosomicides; Thiones; Thiophenes | 1984 |
Oltipraz--antischistosomal efficacy in Sudanese infected with Schistosoma mansoni.
Topics: Administration, Oral; Adolescent; Adult; Child; Clinical Trials as Topic; Dose-Response Relationship, Drug; Feces; Humans; Male; Middle Aged; Parasite Egg Count; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Sudan; Thiones; Thiophenes | 1982 |
Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz.
Topics: Adult; Aged; Aged, 80 and over; Anticarcinogenic Agents; Chemoprevention; Colon; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Glutamate-Cysteine Ligase; Humans; Inactivation, Metabolic; Intestinal Mucosa; Leukocytes, Mononuclear; Male; Middle Aged; Mutagenesis; NAD(P)H Dehydrogenase (Quinone); Pyrazines; Risk; Thiones; Thiophenes | 1996 |
Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes.
Topics: Adult; Aflatoxins; Aged; Anticarcinogenic Agents; Carcinoma, Hepatocellular; China; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Monitoring; Female; Hepatitis B; Humans; Liver Neoplasms; Male; Middle Aged; Pyrazines; Thiones; Thiophenes | 1997 |
Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers.
Topics: Adult; Aflatoxins; Aged; Albumins; Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; China; Dose-Response Relationship, Drug; Genotype; Glutathione Transferase; Humans; Liver Neoplasms; Middle Aged; Pyrazines; Radioimmunoassay; Risk Assessment; Thiones; Thiophenes | 1998 |
Oltipraz chemoprevention trial in Qidong, Jiangsu Province, People's Republic of China.
Topics: Animals; Anticarcinogenic Agents; Carcinoma, Hepatocellular; China; Disease Models, Animal; Double-Blind Method; Humans; Liver Neoplasms; Placebos; Pyrazines; Rats; Thiones; Thiophenes; Treatment Outcome | 1997 |
Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.
Topics: Acetylcysteine; Aflatoxin B1; Anticarcinogenic Agents; Carcinogens; China; Cytochrome P-450 CYP1A2; Double-Blind Method; Drug Administration Schedule; Feasibility Studies; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Humans; Liver Neoplasms; Pyrazines; Reproducibility of Results; Thiones; Thiophenes; Treatment Outcome | 1999 |
Chronic daily low dose of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in patients with previously resected colon polyps and first degree female relatives of breast cancer patients.
Topics: Anticarcinogenic Agents; Biopsy; Breast Neoplasms; Colonic Polyps; Dose-Response Relationship, Drug; Female; Glutathione; Glutathione Transferase; Hot Temperature; Humans; Lymphocytes; Male; Pyrazines; Rectum; Thiones; Thiophenes; Time Factors | 2000 |
Pharmacokinetics of the chemopreventive agent oltipraz and of its metabolite M3 in human subjects after a single oral dose.
Topics: Administration, Oral; Anticarcinogenic Agents; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Colonic Polyps; Colorectal Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male; Pyrazines; Risk Factors; Thiones; Thiophenes; Time Factors | 2000 |
Oltipraz concentrations in plasma, buccal mucosa cells, and lipids: pharmacological studies.
Topics: Administration, Oral; Adult; Anticarcinogenic Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Lipid Metabolism; Lung Neoplasms; Male; Middle Aged; Mouth Mucosa; Probability; Pyrazines; Risk Assessment; Sensitivity and Specificity; Smoking; Statistics, Nonparametric; Thiones; Thiophenes; Tissue Distribution | 2001 |
Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity.
Topics: Acetylcysteine; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fatigue; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Pyrazines; Reference Values; Risk Assessment; Smoking; Thiones; Thiophenes | 2001 |
Oltipraz chemoprevention trial in Qidong, People's Republic of China: results of urine genotoxicity assays as related to smoking habits.
Topics: Administration, Oral; Adult; Biomarkers; Chemoprevention; Escherichia coli; Female; Humans; Male; Mutagenicity Tests; Mutagens; Neoplasms; Pyrazines; Reproducibility of Results; Salmonella typhimurium; Smoking; Thiones; Thiophenes; Urine | 2001 |
Chronic dosing of oltipraz in people at increased risk for colorectal cancer.
Topics: Aged; Aged, 80 and over; Anticarcinogenic Agents; Biomarkers, Tumor; Colorectal Neoplasms; Enzyme Induction; Female; Glutathione; Glutathione Transferase; Humans; Male; Middle Aged; NAD(P)H Dehydrogenase (Quinone); Pyrazines; Thiones; Thiophenes | 2001 |
Assessing the effect of interventions in the context of mixture distributions with detection limits.
Topics: Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Carcinoma, Hepatocellular; China; Double-Blind Method; Humans; Likelihood Functions; Liver Neoplasms; Models, Statistical; Placebos; Pyrazines; Sensitivity and Specificity; Thiones; Thiophenes | 2005 |
Safety and efficacy of weekly oral oltipraz in chronic smokers.
Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Administration, Oral; Adult; Aged; Anticarcinogenic Agents; Bronchoalveolar Lavage Fluid; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Middle Aged; Polycyclic Aromatic Hydrocarbons; Pyrazines; Smoking; Thiones; Thiophenes | 2005 |
Oltipraz chemoprevention trial in Qidong, People's Republic of China: unaltered oxidative biomarkers.
Topics: Anticarcinogenic Agents; Biomarkers; Carcinoma, Hepatocellular; China; DNA; Guanine; Humans; Liver Neoplasms; Oxidation-Reduction; Oxidative Stress; Placebos; Pyrazines; Thiones; Thiophenes | 2006 |
Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1.
Topics: Administration, Oral; Adult; Antiviral Agents; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged; Pyrazines; Thiones; Thiophenes; Transforming Growth Factor beta1 | 2010 |
Oltipraz therapy in patients with liver fibrosis or cirrhosis: a randomized, double-blind, placebo-controlled phase II trial.
Topics: Adult; Anticarcinogenic Agents; Biomarkers; Biopsy; Collagen; Double-Blind Method; Female; Hepatitis B; Hepatitis C; Humans; Liver; Liver Cirrhosis; Male; Middle Aged; Pyrazines; Thiones; Thiophenes; Transforming Growth Factor beta1 | 2011 |
Randomised clinical trial: the efficacy and safety of oltipraz, a liver X receptor alpha-inhibitory dithiolethione in patients with non-alcoholic fatty liver disease.
Topics: Adult; Animals; Double-Blind Method; Fatty Liver; Female; Humans; Liver X Receptors; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Mice; Middle Aged; Non-alcoholic Fatty Liver Disease; Pyrazines; Thiones; Thiophenes; Treatment Outcome; Ultrasonography | 2017 |
268 other study(ies) available for oltipraz and pyrazines
| Article | Year |
|---|---|
[The role of electrochemical techniques in the understanding of the mechanism of drug actions. Example of an anti-Bilharzia agent].
Topics: Electrochemistry; Glutathione Reductase; In Vitro Techniques; Pyrazines; Schistosomicides; Thiones; Thiophenes | 1992 |
Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer 1,2-dithiole-3-thione.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Enzyme Induction; gamma-Glutamyltransferase; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1992 |
Determination of Oltipraz in serum by high-performance liquid chromatography with optical absorbance and mass spectrometric detection.
Topics: Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Pyrazines; Spectrophotometry, Ultraviolet; Thiones; Thiophenes | 1992 |
Clinical pharmacology studies of oltipraz--a potential chemopreventive agent.
Topics: Adult; Anticarcinogenic Agents; Chromatography, High Pressure Liquid; Dietary Fats; Female; Humans; Male; Middle Aged; Pyrazines; Reference Values; Thiones; Thiophenes | 1992 |
Induction of glutathione S-transferase isoenzymes in mouse liver by 5-(2-pyrazynl)-4-methyl-1,2-dithiole-3-thione (oltipraz).
Topics: Animals; Cytosol; Enzyme Induction; Glutathione Transferase; Isoenzymes; Liver; Mice; Pyrazines; Schistosomicides; Substrate Specificity; Thiones; Thiophenes | 1992 |
Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone in A/J mouse lung.
Topics: Adenoma; Animals; Carcinogens; Drug Screening Assays, Antitumor; Female; Intestinal Absorption; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Oxidation-Reduction; Pyrazines; Schistosomicides; Sulindac; Thiones; Thiophenes | 1992 |
Mechanisms of inactivation of Schistosoma mansoni and mammalian glutathione S-transferase activity by the antischistosomal drug oltipraz.
Topics: Animals; Binding Sites; Dithiothreitol; Enzyme Activation; Ethylmaleimide; Glutathione Transferase; Humans; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes | 1992 |
High-performance liquid chromatographic method for the analysis of Oltipraz in human serum and urine.
Topics: Chromatography, High Pressure Liquid; Humans; Pyrazines; Quality Control; Reference Standards; Thiones; Thiophenes | 1992 |
Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.
Topics: Adenoma; Aflatoxin B1; Animals; DNA; gamma-Glutamyltransferase; Growth; Liver; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Survival Analysis; Thiones; Thiophenes | 1991 |
Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats.
Topics: Aflatoxin B1; Animals; Antineoplastic Agents; Biomarkers; DNA; Guanine; Liver Neoplasms, Experimental; Male; Protein Binding; Pyrazines; Rats; Rats, Inbred F344; Serum Albumin; Thiones; Thiophenes | 1992 |
Lipid peroxidation, glutathione and ascorbic acid concentrations in tissues of mice treated with oltipraz: influence of cysteine and olive oil pretreatments.
Topics: Animals; Ascorbic Acid; Brain Chemistry; Cysteine; Glutathione; Kidney; Lipid Peroxidation; Liver; Male; Mice; Olive Oil; Plant Oils; Pyrazines; Thiones; Thiophenes | 1991 |
Oltipraz-induced decrease in the activity of cytosolic glutathione S-transferase in Schistosoma mansoni.
Topics: Animals; Cytosol; Glutathione Peroxidase; Glutathione Transferase; Isoenzymes; Male; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes | 1991 |
Differential effects of oltipraz and its oxy-analogue on the viability of Schistosoma mansoni and the activity of glutathione S-transferase.
Topics: Animals; Dinitrochlorobenzene; Female; Glutathione; Glutathione Transferase; Kinetics; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Tetrazolium Salts; Thiazoles; Thiones; Thiophenes | 1991 |
Toward an understanding of the schistosomicidal effect of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (oltipraz).
Topics: Animals; Disulfides; Glutathione Reductase; Humans; Mice; Models, Chemical; Prodrugs; Pyrazines; Schistosoma; Schistosomiasis; Sulfoxides; Thiones; Thiophenes | 1991 |
Effect of oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Body Weight; Colon; Colonic Neoplasms; Cytosol; DNA; Glutathione Transferase; Intestinal Mucosa; Liver; Male; Methylation; Ornithine Decarboxylase; Protein-Tyrosine Kinases; Pyrazines; Rats; Rats, Inbred F344; Reference Values; Thiones; Thiophenes | 1991 |
Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. I. Lack of dependence on glutathione.
Topics: Acetaminophen; Animals; Cricetinae; Glutathione; Glutathione Disulfide; Liver; Male; Mesocricetus; Oxidation-Reduction; Pyrazines; Schistosomicides; Thiones; Thiophenes | 1991 |
Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. II. Competitive shunt in metabolism via glucuronidation.
Topics: Acetaminophen; Animals; Cricetinae; Glutathione; Liver; Male; Mesocricetus; Models, Biological; Pyrazines; Schistosomicides; Thiones; Thiophenes; Uridine Diphosphate Glucuronic Acid | 1991 |
Inhibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats.
Topics: Animals; Azoxymethane; Diet; Dose-Response Relationship, Drug; Intestinal Neoplasms; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1991 |
New CCK antagonists derived from the amino acid residues of the CCK-8 fragment.
Topics: Amino Acid Sequence; Animals; Brain Chemistry; Cholecystokinin; Female; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Mice; Molecular Sequence Data; Pancreas; Pyrazines; Receptors, Cholecystokinin; Sincalide; Thiones; Thiophenes; Vinyl Compounds | 1991 |
The prophylactic and curative effect of oltipraz in experimental schistosomiasis mansoni in mice.
Topics: Animals; Drug Administration Schedule; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1990 |
Oltipraz treatment in experimental schistosomiasis mansoni:VII. Effect of high dose oral therapy on alkaline phosphatase level in livers of infected mice.
Topics: Alkaline Phosphatase; Animals; Liver; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1990 |
Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver.
Topics: Animals; Base Sequence; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Genes; Glutathione Transferase; Kinetics; Liver; Macromolecular Substances; Male; Methylation; Pyrazines; Rats; Rats, Inbred F344; Restriction Mapping; Schistosomicides; Thiones; Thiophenes; Transcription, Genetic | 1990 |
Effect of oltipraz on the susceptibility of adult Schistosoma mansoni to killing by mouse peritoneal exudate cells.
Topics: Animals; Glutathione; Immunity, Cellular; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Peritoneal Cavity; Phagocytes; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes | 1990 |
Metabolism of oltipraz and glutathione reductase inhibition.
Topics: Animals; Glutathione Reductase; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes | 1990 |
Oltipraz treatment in experimental schistosomiasis mansoni. I. Morphological changes among S. mansoni worms induced by high dose oral therapy in mice.
Topics: Animals; Female; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1989 |
Oltipraz treatment in experimental schistosomiasis mansoni. II. Effect of high dose oral therapy on worm load and process of copulation in infected mice.
Topics: Animals; Female; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1989 |
Oltipraz treatment in experimental schistosomiasis mansoni: III. Effect of high dose oral therapy on hepatic shift of worms and tissue bound ova pattern in infected mice.
Topics: Animals; Liver; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1989 |
Oltipraz treatment in experimental schistosomiasis mansoni: IV. Histopathological changes in the intestines of infected mice induced by high dose oral therapy.
Topics: Animals; Intestine, Small; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1989 |
Oltipraz treatment in experimental schistosomiasis mansoni: V. Histopathological changes in the livers of infected mice induced by high dose oral therapy.
Topics: Animals; Liver; Liver Diseases, Parasitic; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1989 |
Oltipraz treatment in experimental schistosomiasis mansoni: VI. Effect of high dose oral therapy on alkaline phosphatase level in the intestines of infected mice.
Topics: Alkaline Phosphatase; Animals; Intestines; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1989 |
Glutathione redox state, lipid peroxide levels, and activities of glutathione enzymes in oltipraz-treated adult Schistosoma mansoni.
Topics: Animals; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxides; Mice; Oxidation-Reduction; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1989 |
Factors influencing the induction of DNA single strand breaks in rats by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Topics: Animals; Cell Nucleus; DNA Damage; DNA, Single-Stranded; Dose-Response Relationship, Drug; Female; Iron; Lipid Peroxides; Liver; Malondialdehyde; Pyrazines; Rats; Rats, Inbred Strains; Receptors, Aryl Hydrocarbon; Receptors, Drug; Subcellular Fractions; Thiones; Thiophenes; Time Factors | 1989 |
Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.
Topics: Aflatoxin B1; Aflatoxins; Animals; Antineoplastic Agents; Cytochrome P-450 Enzyme System; DNA; Enzyme Induction; gamma-Glutamyltransferase; Glutathione Transferase; Heterocyclic Compounds; Liver Neoplasms, Experimental; Male; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiones; Thiophenes | 1987 |
Measurement of peak blood levels of oltipraz in patients infected with S. mansoni: correlation with the drug's antischistosomal action.
Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Feces; Humans; Male; Parasite Egg Count; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1986 |
Oltipraz: administration with food increases its anti-schistosomal activity.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Child; Feces; Food; Humans; Kinetics; Male; Middle Aged; Parasite Egg Count; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1986 |
[Eosinophilic granulomatous hepatitis. Apropos of 3 cases].
Topics: Adult; Chemical and Drug Induced Liver Injury; Eosinophilic Granuloma; Humans; Male; Pyrazines; Schistosomiasis haematobia; Schistosomicides; Thiones; Thiophenes | 1987 |
Protection by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B1 in the rat.
Topics: Aflatoxin B1; Aflatoxins; Animals; Body Weight; Butylated Hydroxytoluene; DNA; Enzyme Induction; Glutathione Transferase; Liver; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1988 |
[The therapeutic effectiveness of oltipraz on mice with Schistosomiasis japonica].
Topics: Animals; Mice; Pyrazines; Schistosomiasis japonica; Schistosomicides; Thiones; Thiophenes | 1988 |
Circulating antigens for assessing cure in schistosomiasis mansoni.
Topics: Adolescent; Adult; Antibodies, Helminth; Antigens, Helminth; Child; Enzyme-Linked Immunosorbent Assay; Feces; Female; Humans; Male; Oxamniquine; Parasite Egg Count; Praziquantel; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1988 |
Oltipraz-induced reduction in schistosomal glucose utilization rates.
Topics: Animals; Deoxyglucose; Female; Glucose; Male; Phosphorylation; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes | 1988 |
Effect of oltipraz on the metabolism of glutathione in Schistosoma mansoni.
Topics: Animals; Cysteine; Glutathione; Glutathione Synthase; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes | 1988 |
Acute effects of oltipraz on adult Schistosoma mansoni and its antagonism in vitro.
Topics: Animals; Biological Transport; Cysteine; Cystine; Glutathione; Kinetics; Male; Membrane Potentials; Mice; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes | 1987 |
Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (Oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard.
Topics: Animals; Benzo(a)pyrene; Diethylnitrosamine; Female; Lung Neoplasms; Mice; Mice, Inbred ICR; Neoplasms, Experimental; Pyrazines; Stomach Neoplasms; Thiones; Thiophenes; Uracil Mustard | 1986 |
Biochemical effects of dithiolthiones.
Topics: Animal Feed; Animals; Brassica; Butylated Hydroxyanisole; Female; Glutathione; Glutathione Transferase; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiones; Thiophenes | 1986 |
Drug resistance in schistosomiasis.
Topics: Animals; Drug Resistance; Mice; Oxamniquine; Praziquantel; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes | 1986 |
Effects of oltipraz, BHA, ADT and cabbage on glutathione metabolism, DNA damage and lipid peroxidation in old mice.
Topics: Aging; Anethole Trithione; Animals; Anisoles; Brassica; Butylated Hydroxyanisole; Diet; DNA; Female; Freeze Drying; Glutathione; Glutathione Reductase; Lipid Peroxides; Mice; Pyrazines; Thiones; Thiophenes | 1986 |
Dithiolthione-induced alterations in hepatic glutathione and related enzymes in male mice.
Topics: Anethole Trithione; Animals; Anisoles; Glutathione; Glutathione Disulfide; Glutathione Transferase; Liver; Male; Mice; Pyrazines; Thiones; Thiophenes | 1987 |
Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione.
Topics: Aflatoxin B1; Aflatoxins; Animals; Anisoles; Antioxidants; Butylated Hydroxyanisole; Butylated Hydroxytoluene; DNA; Ethoxyquin; Glutathione Transferase; Kidney; Liver; Male; Pyrazines; Quinolines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1985 |
Disposition of 14C-oltipraz in animals. Pharmacokinetics in mice, rats and monkeys. Comparison of the biotransformation in the infected mouse and in the schistosomes.
Topics: Animals; Biotransformation; Female; Macaca mulatta; Male; Mice; Pyrazines; Rats; Rats, Inbred Strains; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Species Specificity; Thiones; Thiophenes | 1985 |
Changes in endogenous DNA damage in aging mice in response to butylated hydroxyanisole and oltipraz.
Topics: Aging; Animals; Antioxidants; Butylated Hydroxyanisole; DNA, Single-Stranded; Female; Glutathione; Liver; Mice; Mice, Inbred Strains; Pyrazines; Thiones; Thiophenes | 1985 |
Assessment of 35972 RP (oltipraz) a new antischistosomal drug against Schistosoma haematobium, Schistosoma mansoni, and Schistosoma intercalatum.
Topics: Adolescent; Adult; Child; Drug Administration Schedule; Drug Tolerance; Humans; Pyrazines; Schistosoma haematobium; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes | 1980 |
[Urinary schistosomiasis. 1st trial of mass treatment in the field (Niger)].
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Female; Humans; Infant; Male; Mass Screening; Niger; Parasite Egg Count; Pyrazines; Schistosomiasis; Schistosomicides; Sex Factors; Thiones; Thiophenes; Urinary Tract Infections | 1983 |
The oral treatment of urinary schistosomiasis in Egyptian patients with 'Oltipraz'.
Topics: Administration, Oral; Adolescent; Adult; Follow-Up Studies; Humans; Parasite Egg Count; Pyrazines; Schistosoma haematobium; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Urologic Diseases | 1984 |
[Treatment of 700 cases of bilharziasis with the new drugs oxamniquine, oltipraz, praziquantel].
Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Isoquinolines; Middle Aged; Nitroquinolines; Oxamniquine; Paris; Praziquantel; Pyrazines; Schistosoma haematobium; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Togo | 1983 |
Comparison of the metabolism of oltipraz in the mouse, rat and monkey and in man. Distribution of the metabolites in each species.
Topics: Acetylation; Animals; Biotransformation; Chromatography, Gas; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Feces; Female; Humans; Macaca mulatta; Male; Mice; Pyrazines; Rats; Rats, Inbred Strains; Species Specificity; Thiones; Thiophenes; Tissue Distribution | 1983 |
Method for the determination of oltipraz, a new antischistosomal agent, in blood.
Topics: Chromatography, Gas; Humans; Pyrazines; Schistosomicides; Thiones; Thiophenes | 1984 |
Effect of cysteine on oltipraz blood levels in green monkeys (Cercopithecus aethiops).
Topics: Animals; Biological Availability; Chlorocebus aethiops; Cysteine; Diet; Female; Kinetics; Male; Pyrazines; Schistosomicides; Sex Characteristics; Thiones; Thiophenes | 1984 |
[Praziquantel and oltipraz, 2 new polyvalent anthelmintics].
Topics: Animals; Anthelmintics; Humans; Isoquinolines; Mice; Praziquantel; Pyrazines; Rats; Schistosomiasis; Schistosomicides; Thiones; Thiophenes | 1982 |
The antischistosomal activity of oltipraz.
Topics: Animals; Enzyme Induction; Female; Glutathione; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Structure-Activity Relationship; Thiones; Thiophenes; Time Factors | 1982 |
[Treatment of bilharziasis in Madagascar. Use of oltipraz in mass campaign against S. mansoni and S. haematobium].
Topics: Humans; Madagascar; Pyrazines; Schistosoma haematobium; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes | 1982 |
[Mass treatment of urinary bilharziasis with a single dose of oltipraz in Madagascar].
Topics: Adolescent; Child; Child, Preschool; Female; Humans; Madagascar; Male; Pyrazines; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Urinary Tract Infections | 1982 |
[Oltipraz in one-day treatment of Schistosoma haematobium bilharziasis (pharmacokinetic data, therapeutic effects)].
Topics: Drug Administration Schedule; Female; Humans; Kinetics; Male; Pyrazines; Schistosoma haematobium; Schistosomiasis; Schistosomicides; Thiones; Thiophenes | 1981 |
[Therapy of Schistosoma mansoni bilharziasis with RP. 35972 (Oltipraz). Preliminary results of initial therapy in Madagascar].
Topics: Adult; Aged; Female; Humans; Madagascar; Male; Middle Aged; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes | 1981 |
Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz.
Topics: Animals; Anticarcinogenic Agents; Base Sequence; Butylated Hydroxyanisole; Catalysis; Cytochrome P-450 Enzyme System; Enzyme Activation; Enzyme Induction; Ethoxyquin; Glutathione Transferase; Isoenzymes; Male; Molecular Sequence Data; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes | 1995 |
Inactivation of human immunodeficiency virus type 1 reverse transcriptase by oltipraz: evidence for the formation of a stable adduct.
Topics: Antiviral Agents; Binding Sites; Chromatography, Affinity; DNA Polymerase I; Enzyme Stability; Escherichia coli; HIV Reverse Transcriptase; HIV-1; Kinetics; Magnesium; Mutation; Pyrazines; Recombinant Proteins; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Thiones; Thiophenes | 1995 |
Coordinate induction of glutathione S-transferase alpha, mu, and pi expression in murine liver after a single administration of oltipraz.
Topics: Animals; Enzyme Induction; Female; Glutathione Transferase; Isoenzymes; Liver; Mice; Mice, Inbred ICR; Pyrazines; RNA; Schistosomicides; Thiones; Thiophenes | 1994 |
Fluorometric measurement of reverse transcriptase activity with 4',6-diamidino-2-phenylindole.
Topics: Antiviral Agents; Dideoxynucleotides; Fluorescent Dyes; HIV Reverse Transcriptase; HIV-1; Indicators and Reagents; Indoles; Kinetics; Nevirapine; Phosphorus Radioisotopes; Pyrazines; Pyridines; Radioisotope Dilution Technique; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Spectrometry, Fluorescence; Thiones; Thiophenes; Thymine Nucleotides; Zidovudine | 1995 |
Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz.
Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Pyrazines; Reverse Transcriptase Inhibitors; Thiones; Thiophenes; Tumor Cells, Cultured; Virus Replication | 1995 |
Chemopreventive activity of Oltipraz against N-nitrosobis(2-oxopropyl)amine (BOP)-induced ductal pancreatic carcinoma development and effects on survival of Syrian golden hamsters.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Carcinoma, Ductal, Breast; Cricetinae; Female; Glutathione Transferase; Immunohistochemistry; Liver; Mesocricetus; Nitrosamines; Pancreas; Pancreatic Neoplasms; Pyrazines; Thiones; Thiophenes; Tumor Suppressor Protein p53 | 1995 |
Regional chemoprevention of carcinogen-induced tumors in rat colon.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; Colonic Neoplasms; Eflornithine; Ellagic Acid; Male; Piroxicam; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1995 |
Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture.
Topics: Aflatoxin B1; Aged; Anticarcinogenic Agents; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Female; Glutathione Transferase; Humans; Infant; Liver; Male; Methylcholanthrene; Middle Aged; Mixed Function Oxygenases; Oxidoreductases; Pyrazines; Rifampin; Thiones; Thiophenes; Time Factors | 1995 |
Clinical development plan: oltipraz.
Topics: Animals; Anticarcinogenic Agents; Clinical Trials as Topic; Cricetinae; Dogs; Drug Approval; Humans; Mice; Pyrazines; Rabbits; Rats; Thiones; Thiophenes | 1994 |
Levels of aflatoxin-albumin biomarkers in rat plasma are modulated by both long-term and transient interventions with oltipraz.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Biomarkers; Male; Pyrazines; Rats; Rats, Inbred F344; Serum Albumin; Thiones; Thiophenes | 1995 |
Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Carcinogens; Enzyme Induction; Glutathione Transferase; Isoenzymes; Liver; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1995 |
Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Glutathione; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Lymphoma, T-Cell, Cutaneous; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Pyrazines; Reverse Transcriptase Inhibitors; Skin Neoplasms; Thiones; Thiophenes; Time Factors; Tumor Cells, Cultured; Virus Replication; Zidovudine | 1993 |
Failure of dietary oltipraz to inhibit benzo[a]pyrene-induced lung tumorigenesis in strain a mice.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Benzopyrenes; Diet; Female; Glutathione Transferase; Lung; Lung Neoplasms; Mice; Mice, Inbred A; Pyrazines; Thiones; Thiophenes | 1995 |
Involvement of NF-kappa B in the induction of NAD(P)H:quinone oxidoreductase (DT-diaphorase) by hypoxia, oltipraz and mitomycin C.
Topics: Anticarcinogenic Agents; Base Sequence; Cell Hypoxia; Enzyme Induction; Humans; Mitomycin; Molecular Sequence Data; NAD(P)H Dehydrogenase (Quinone); NF-kappa B; Protein Binding; Pyrazines; Signal Transduction; Thiones; Thiophenes; Tumor Cells, Cultured | 1995 |
Inhibition of the transforming ability of cigarette smoking condensate-treated human fetal lung DNA induced by oltipraz.
Topics: Animals; Anticarcinogenic Agents; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA; Humans; Lung; Nicotiana; Organ Culture Techniques; Plants, Toxic; Pyrazines; Rats; Smoke; Thiones; Thiophenes; Transformation, Genetic | 1994 |
Elevation of glutathione levels by phase II enzyme inducers: lack of inhibition of human immunodeficiency virus type 1 replication in chronically infected monocytoid cells.
Topics: Antiviral Agents; Cell Line; Dimethyl Fumarate; Dithiothreitol; Enzyme Induction; Fumarates; Glutathione; HIV-1; Monocytes; NAD(P)H Dehydrogenase (Quinone); NF-kappa B; Pyrazines; Sulfhydryl Compounds; Tetradecanoylphorbol Acetate; Thiones; Thiophenes; Virus Replication | 1994 |
[Study on initiation of human lung carcinogenesis].
Topics: Anticarcinogenic Agents; Cell Transformation, Neoplastic; Cells, Cultured; Diethylnitrosamine; Humans; Lung Neoplasms; Pyrazines; Smoking; Thiones; Thiophenes | 1993 |
Evaluation of the post-initiation effects of oltipraz on aflatoxin B1-induced preneoplastic foci in a rat model of hepatic tumorigenesis.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Body Weight; Glutathione Transferase; Liver; Liver Neoplasms, Experimental; Male; Organ Size; Precancerous Conditions; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes; Time Factors | 1993 |
Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones.
Topics: Animals; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Liver; Mice; NAD(P)H Dehydrogenase (Quinone); Pyrazines; Structure-Activity Relationship; Thiones; Thiophenes; Transfection; Tumor Cells, Cultured | 1994 |
Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; DNA; DNA Adducts; Glutathione Transferase; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1993 |
Preferential increase of glutathione S-transferase class alpha transcripts in cultured human hepatocytes by phenobarbital, 3-methylcholanthrene, and dithiolethiones.
Topics: Cells, Cultured; Enzyme Induction; Gene Expression; Glutathione Transferase; Humans; Liver; Methylcholanthrene; Phenobarbital; Pyrazines; RNA, Messenger; Thiones; Thiophenes | 1993 |
An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes.
Topics: Animals; Follow-Up Studies; Glucuronidase; Liver; Lysosomes; Male; Mice; Naphthol AS D Esterase; Praziquantel; Pyrazines; Ribonucleases; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1993 |
Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones.
Topics: Animals; Antineoplastic Agents; Enzyme Induction; Female; Glutathione Transferase; Intestine, Small; Kidney; Lung; Male; Organ Specificity; Pyrazines; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stomach; Thiones; Thiophenes | 1993 |
Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoxymethane in male F344 rats.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azoxymethane; Colonic Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1993 |
Effect of schistosomal infection and its treatment on some key enzymes of glucose metabolism in mice livers.
Topics: Animals; Body Weight; Citric Acid Cycle; Female; Glucose; Glycolysis; Liver; Liver Glycogen; Male; Mice; Organ Size; Oxamniquine; Pentose Phosphate Pathway; Praziquantel; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes | 1995 |
Oltipraz-mediated changes in aflatoxin B(1) biotransformation in rat liver: implications for human chemointervention.
Topics: Aflatoxin B1; Aflatoxins; Animals; Anticarcinogenic Agents; Base Sequence; Biotransformation; Carcinogens; Clofibric Acid; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Fibric Acids; Glutathione Transferase; Humans; Isoenzymes; Liver; Male; Methylcholanthrene; Mice; Molecular Sequence Data; Oxidation-Reduction; Oxidoreductases; Pregnenolone Carbonitrile; Pyrazines; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Species Specificity; Steroid Hydroxylases; Thiones; Thiophenes | 1996 |
Inhibition of human immunodeficiency virus type 1 long terminal repeat-driven transcription by an in vivo metabolite of oltipraz: implications for antiretroviral therapy.
Topics: Antiviral Agents; Base Sequence; Cell Line; HIV Long Terminal Repeat; HIV-1; Molecular Sequence Data; NF-kappa B; Oligodeoxyribonucleotides; Pyrazines; Thiones; Thiophenes; Transcription, Genetic; Virus Replication | 1996 |
Regulation of carbonyl-reducing enzymes in rat liver by chemoprotectors.
Topics: Aldehyde Reductase; Animals; Antioxidants; Barbiturates; Butylated Hydroxyanisole; Carcinogens; Enzyme Induction; Ethoxyquin; Liver; Methylcholanthrene; Oxidation-Reduction; Phenobarbital; Pyrazines; Rats; Thiones; Thiophenes | 1996 |
A comparison of the effect of inducers on the expression of glutathione-S-transferases in the liver of the intact rat and in hepatocytes in primary culture.
Topics: Animals; Cells, Cultured; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Liver; Male; Methylcholanthrene; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes | 1996 |
Inhibition of aflatoxin Ml excretion in rat urine during dietary intervention with oltipraz.
Topics: Aflatoxin B1; Aflatoxin M1; Animals; Anticarcinogenic Agents; Cytochrome P-450 Enzyme System; Diet; Dose-Response Relationship, Drug; Inactivation, Metabolic; Liver; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1996 |
Effect of oltipraz, alpha-tocopherol, beta-carotene and phenethylisothiocyanate on rat oesophageal, gastric, colonic and hepatic glutathione, glutathione S-transferase and peroxidase.
Topics: Animals; Anticarcinogenic Agents; beta Carotene; Carotenoids; Colon; Esophagus; Gastric Mucosa; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Intestinal Mucosa; Isothiocyanates; Liver; Male; Organ Specificity; Pyrazines; Rats; Rats, Wistar; Selenium; Thiones; Thiophenes; Vitamin E | 1996 |
Inhibition of 2-Amino-1-methyl-6-phenylimidazo[4,5]pyridine-induced lymphoma formation by oltipraz.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Imidazoles; Intestinal Neoplasms; Lymphoma; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1996 |
Metabolism of aflatoxin B1 by human hepatocytes in primary culture.
Topics: Aflatoxin B1; Anticarcinogenic Agents; Carcinogens; Cells, Cultured; Enzyme Induction; Glutathione; Glutathione Transferase; Humans; Liver; Methylcholanthrene; Pyrazines; Thiones; Thiophenes | 1996 |
Transcription regulation of rat glutathione S-transferase Ya subunit gene expression by chemopreventive agents.
Topics: Anticarcinogenic Agents; Blotting, Northern; Chloramphenicol O-Acetyltransferase; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation; Genes, Reporter; Glutathione Transferase; Humans; Isothiocyanates; Liver; Pyrazines; Sulfoxides; Tamoxifen; Thiocyanates; Thiones; Thiophenes; Time Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured | 1996 |
Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo(a)pyrene-7,8-dihydrodiol.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Cell Line; Dihydroxydihydrobenzopyrenes; DNA, Complementary; Enzyme Induction; Female; Glucuronosyltransferase; Molecular Sequence Data; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1997 |
Chronic toxicity studies of 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione, a potential chemopreventive agent.
Topics: Administration, Oral; Alkaline Phosphatase; Animals; Anticarcinogenic Agents; Blood Chemical Analysis; Body Weight; Cholesterol; Dogs; Female; Hematologic Tests; Kidney; Liver; Male; No-Observed-Adverse-Effect Level; Organ Size; Prostate; Pyrazines; Rats; Rats, Inbred F344; Survival Rate; Thiones; Thiophenes | 1997 |
Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials.
Topics: Acetylcysteine; Adult; Anticarcinogenic Agents; Biomarkers, Tumor; Chemoprevention; China; Clinical Trials, Phase II as Topic; Cohort Studies; DNA Repair; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutagenicity Tests; Mutagens; Netherlands; Pyrazines; Research Design; Smoking; Thiones; Thiophenes | 1996 |
Increase of cytochrome P-450 1A and glutathione transferase transcripts in cultured hepatocytes from dogs, monkeys, and humans after cryopreservation.
Topics: Animals; Cell Survival; Cells, Cultured; Cryopreservation; Cyclopentanes; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Dogs; Glutathione Transferase; Haplorhini; Humans; Liver; Phenobarbital; Pyrazines; RNA, Messenger; Thiones; Thiophenes | 1996 |
Induction of a rat liver benzo[a]pyrene-trans-7,8-dihydrodiol glucuronidating activity by oltipraz and beta-naphthoflavone.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Enzyme Induction; Female; Glucuronates; Glucuronosyltransferase; Microsomes, Liver; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1997 |
The chemopreventive agent oltipraz stimulates repair of damaged DNA.
Topics: Anticarcinogenic Agents; Cisplatin; DNA Adducts; DNA Damage; DNA Repair; DNA, Neoplasm; Humans; Pyrazines; Thiones; Thiophenes; Tumor Cells, Cultured | 1997 |
Evidence for thiol-dependent production of oxygen radicals by 4-methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione (oltipraz) and 3H-1,2-dithiole-3-thione: possible relevance to the anticarcinogenic properties of 1,2-dithiole-3-thiones.
Topics: Anaerobiosis; Anticarcinogenic Agents; Buffers; Chelating Agents; Chemical Phenomena; Chemistry, Physical; DNA Damage; Electrophoresis, Polyacrylamide Gel; Free Radical Scavengers; Free Radicals; Plasmids; Pyrazines; Sulfhydryl Compounds; Thiones; Thiophenes | 1997 |
Enhancement of radiation-induced hepatic microsomal epoxide hydrolase gene expression by oltipraz in rats.
Topics: Animals; Anticarcinogenic Agents; Epoxide Hydrolases; Gamma Rays; Gene Expression Regulation, Enzymologic; Male; Microsomes, Liver; Pyrazines; Rats; RNA, Messenger; Thiones; Thiophenes; Time Factors | 1997 |
Modulation of glutathione S-transferase subunits A2, M1, and P1 expression by interleukin-1beta in rat hepatocytes in primary culture.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glutathione Transferase; Humans; Interleukin-1; Liver; Male; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes; Transforming Growth Factor beta | 1997 |
Enhancement of radiation-inducible hepatic glutathione-S-transferases Ya, Yb1, Yb2, Yc1, and Yc2 gene expression by oltipraz: possible role in radioprotection.
Topics: Animals; Gene Expression; Glutathione Transferase; Liver; Male; Pyrazines; Radiation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Inhibitors; Thiones; Thiophenes | 1997 |
Correspondence re: C.V. Rao, et al., Inhibition of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced lymphoma formation by oltipraz. Cancer Res., 56: 3395-3398, 1996.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Hematologic Neoplasms; Imidazoles; Lymphoma; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1997 |
Effects of administration of the chemoprotective agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Caffeine; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Liver; Male; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes | 1997 |
Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Biomarkers, Tumor; Carcinogens; Cell Transformation, Neoplastic; DNA Adducts; Dose-Response Relationship, Drug; Drug Administration Schedule; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1997 |
Oltipraz stimulates the transcription of the manganese superoxide dismutase gene in rat hepatocytes.
Topics: Animals; Anticarcinogenic Agents; Lipid Peroxidation; Liver; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Thiones; Thiophenes; Transcription, Genetic | 1997 |
Phase II-selective induction of hepatic drug-metabolizing enzymes by oltipraz -5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione-, 1,7-phenanthroline, and 2,2'-dipyridyl in rats is not accompanied by induction of intestinal enzymes.
Topics: 2,2'-Dipyridyl; Animals; Butylated Hydroxyanisole; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Intestines; Male; Microsomes, Liver; Molecular Structure; NAD(P)H Dehydrogenase (Quinone); Phenanthrolines; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes | 1998 |
Transcriptional activation of the UDP-glucuronosyltransferase 1A7 gene in rat liver by aryl hydrocarbon receptor ligands and oltipraz.
Topics: Animals; Base Sequence; Cells, Cultured; Cloning, Molecular; Cytochrome P-450 Enzyme System; Genes, Reporter; Glucuronosyltransferase; Liver; Male; Molecular Sequence Data; Polycyclic Aromatic Hydrocarbons; Promoter Regions, Genetic; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; RNA, Messenger; Sequence Analysis, DNA; Thiones; Thiophenes; Transcriptional Activation; Transfection | 1998 |
Chemopreventive activity of oltipraz against induction of glandular stomach carcinogenesis in rats by N-methyl-N'-nitro-N-nitrosoguanidine.
Topics: Adenocarcinoma; Animals; Anticarcinogenic Agents; Hyperplasia; Male; Methylnitronitrosoguanidine; Pylorus; Pyrazines; Rats; Rats, Wistar; Stomach Neoplasms; Thiones; Thiophenes | 1998 |
In vivo radioprotective effects of oltipraz in gamma-irradiated mice.
Topics: Animals; Dexamethasone; Epoxide Hydrolases; Gamma Rays; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Liver; Male; Mice; Mice, Inbred ICR; Pyrazines; Radiation-Protective Agents; Survival Rate; Thiones; Thiophenes | 1998 |
Inhibition of cigarette smoke-related lipophilic DNA adducts in rat tissues by dietary oltipraz.
Topics: Animals; Anticarcinogenic Agents; DNA Adducts; Female; Lung; Myocardium; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Tobacco Smoke Pollution; Trachea; Urinary Bladder | 1998 |
Identification of dithiolethiones with better chemopreventive properties than oltipraz.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Enzyme Induction; Liver; Liver Neoplasms, Experimental; Male; Pyrazines; Rats; Rats, Inbred F344; Thiones; Thiophenes | 1998 |
Cellular kinetics of induction by oltipraz and its keto derivative of detoxication enzymes in human colon adenocarcinoma cells.
Topics: Adenocarcinoma; Anticarcinogenic Agents; Cell Cycle; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Glutathione Transferase; Humans; Inactivation, Metabolic; Kinetics; NAD(P)H Dehydrogenase (Quinone); Pyrazines; RNA, Messenger; Thiones; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent.
Topics: Administration, Oral; Anticarcinogenic Agents; Area Under Curve; Biological Availability; Enzyme Induction; Glutathione; Glutathione Transferase; Humans; Lymphocytes; Pilot Projects; Pyrazines; Thiones; Thiophenes; Time Factors | 1995 |
Lipopolysaccharide inhibition of rat hepatic microsomal epoxide hydrolase and glutathione S-transferase gene expression irrespective of nuclear factor-kappaB activation.
Topics: Animals; Anticarcinogenic Agents; Disulfides; Epoxide Hydrolases; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Isoenzymes; Kinetics; Lipopolysaccharides; Male; Microsomes, Liver; NF-kappa B; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes; Transcription, Genetic | 1998 |
Endotoxin suppresses the oltipraz-mediated induction of major hepatic glutathione transferases and cytochromes P450 in the rat.
Topics: Animals; Anticarcinogenic Agents; Cytochrome P-450 Enzyme System; Endotoxins; Enzyme Induction; Glutathione Transferase; Lipopolysaccharides; Liver; Male; Pyrazines; Rats; Rats, Wistar; RNA, Messenger; Thiones; Thiophenes | 1998 |
Drug-metabolizing enzyme induction by 2,2'-dipyridyl, 1,7-phenanthroline, 7,8-benzoquinoline and oltipraz in mouse.
Topics: 2,2'-Dipyridyl; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Enzyme Activation; Glucuronosyltransferase; Glutathione Transferase; Male; Mice; Mice, Inbred Strains; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); Phenanthrolines; Pyrazines; Quinolines; Species Specificity; Thiones; Thiophenes | 1998 |
Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein.
Topics: Alleles; Antiviral Agents; DNA, Viral; Hepatitis B virus; Humans; Pyrazines; Reverse Transcriptase Inhibitors; RNA, Viral; Thiones; Thiophenes; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53; Virus Integration; Virus Replication | 1998 |
Induction of drug metabolizing enzymes by 1,7-phenanthroline and oltipraz in mice is unrelated to Ah-responsiveness.
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); Phenanthrolines; Pyrazines; Receptors, Aryl Hydrocarbon; Species Specificity; Thiones; Thiophenes | 1999 |
Molecular basis for hepatic detoxifying enzyme induction by 2-(allylthio)pyrazine in rats in comparison with oltipraz: effects on prooxidant production and DNA degradation.
Topics: Animals; Antioxidants; Blotting, Northern; Buthionine Sulfoximine; Cysteine; Cytochrome P-450 CYP2E1 Inhibitors; DNA Damage; Enzyme Induction; Enzyme Inhibitors; Epoxide Hydrolases; Glutathione; Glutathione Transferase; Immunoblotting; Inactivation, Metabolic; Liver; Male; Microsomes, Liver; NF-kappa B; Oxidants; Pyrazines; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Thiones; Thiophenes | 1999 |
Differential regulation of canalicular multispecific organic anion transporter (cMOAT) expression by the chemopreventive agent oltipraz in primary rat hepatocytes and in rat liver.
Topics: Animals; Anion Transport Proteins; Anticarcinogenic Agents; Carrier Proteins; Cells, Cultured; Liver; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiones; Thiophenes; Up-Regulation | 1999 |
Inhibition of aflatoxin M1 production by bovine hepatocytes after intervention with oltipraz.
Topics: Aflatoxin M1; Animal Feed; Animals; Anticarcinogenic Agents; Cattle; Cell Culture Techniques; Cytochrome P-450 Enzyme System; Food Contamination; Liver; Milk; Pyrazines; Thiones; Thiophenes | 2000 |
Effects of dietary oltipraz and ethoxyquin on aflatoxin B1 biotransformation in non-human primates.
Topics: Aflatoxin B1; Albumins; Animals; Anticarcinogenic Agents; Biotransformation; Callithrix; Carcinogens; Cytosol; Diet; DNA Adducts; Ethoxyquin; Glutathione Transferase; Humans; In Vitro Techniques; Macaca nemestrina; Male; Microsomes, Liver; Oxidation-Reduction; Pyrazines; Species Specificity; Teratogens; Thiones; Thiophenes | 2000 |
Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane.
Topics: Anticarcinogenic Agents; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Humans; Isothiocyanates; Pyrazines; Quinolines; Sulfoxides; Thiocyanates; Thiones; Thiophenes | 2000 |
Organ-dependent modifying effects of oltipraz on N-nitrosobis(2-oxopropyl)amine (BOP)-initiation of tumorigenesis in hamsters.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Carcinogens; Cell Transformation, Neoplastic; Cricetinae; Female; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Organ Size; Pyrazines; Thiones; Thiophenes | 2000 |
Reduction of aflatoxin B(1) adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis).
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Antiviral Agents; Biomarkers; Chromatography, High Pressure Liquid; DNA Adducts; Female; Hepatitis B virus; Humans; Liver Neoplasms; Male; Pyrazines; Radioimmunoassay; Thiones; Thiophenes; Time Factors; Tupaiidae | 2000 |
Modulation of glutathione S-transferase alpha by hepatitis B virus and the chemopreventive drug oltipraz.
Topics: Antiviral Agents; Gene Expression Regulation, Enzymologic; Glutathione Transferase; Hepatitis B; Hepatitis B virus; Humans; Isoenzymes; Promoter Regions, Genetic; Pyrazines; RNA, Messenger; Sp1 Transcription Factor; Thiones; Thiophenes; Trans-Activators; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Viral Regulatory and Accessory Proteins | 2000 |
Early events in the induction of rat hepatic UDP-glucuronosyltransferases, glutathione S-transferase, and microsomal epoxide hydrolase by 1,7-phenanthroline: comparison with oltipraz, tert-butyl-4-hydroxyanisole, and tert-butylhydroquinone.
Topics: Animals; Butylated Hydroxyanisole; Enzyme Induction; Enzymes; Epoxide Hydrolases; Glucuronosyltransferase; Glutathione Transferase; Hydroquinones; Isoenzymes; Liver; Male; Phenanthrolines; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiones; Thiophenes; Time Factors | 2000 |
Effects of chemopreventive and antitelomerase agents on the spontaneous immortalization of breast epithelial cells.
Topics: Antineoplastic Agents; Breast; Breast Neoplasms; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Disease Progression; DNA, Complementary; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Female; Humans; Li-Fraumeni Syndrome; Oligodeoxyribonucleotides, Antisense; Point Mutation; Pyrazines; Reverse Transcriptase Inhibitors; Tamoxifen; Telomerase; Thiones; Thiophenes; Transformation, Genetic; Tretinoin | 2001 |
1,2-dithiole-3-thione and its structural analogue oltipraz are potent inhibitors of dibenz.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzopyrenes; Body Weight; Chromatography; DNA Adducts; Female; Liver; Lung; Mammary Glands, Animal; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2001 |
Differential effects of oltipraz on CYP1A and CYP2B in rat lung.
Topics: Animals; Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Cytosol; Glutathione Transferase; Isoenzymes; Kidney; Lipopolysaccharides; Lung; Male; Oxidoreductases, N-Demethylating; Peptide Hydrolases; Proteasome Endopeptidase Complex; Pyrazines; Rats; Rats, Wistar; RNA, Messenger; Thiones; Thiophenes | 2001 |
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Carcinogenicity Tests; Carcinogens; Cell Nucleus; Disease Models, Animal; Disease Susceptibility; DNA-Binding Proteins; Epoxide Hydrolases; Female; FMN Reductase; Gene Expression; Genotype; Glucuronosyltransferase; Glutathione Transferase; Mice; Mice, Inbred ICR; Mice, Knockout; NADH, NADPH Oxidoreductases; NF-E2-Related Factor 2; Pyrazines; Stomach Neoplasms; Thiones; Thiophenes; Trans-Activators | 2001 |
Modulation of biomarkers by chemopreventive agents in smoke-exposed rats.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Biomarkers; DNA Adducts; DNA Damage; Eating; Hemoglobins; Inhalation Exposure; Lung; Male; Micronuclei, Chromosome-Defective; Nicotiana; Oxidation-Reduction; Plants, Toxic; Pyrazines; Rats; Rats, Sprague-Dawley; Smoke; Smoking; Thiones; Thiophenes; Tobacco Smoke Pollution; Weight Gain | 2001 |
Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arteriosclerosis; Chemoprevention; DNA Adducts; Eating; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Smoking; Thiones; Thiophenes; Weight Gain | 2001 |
An alternative promoter contributes to tissue- and inducer-specific expression of the rat UDP-glucuronosyltransferase 1A6 gene.
Topics: 5' Untranslated Regions; Animals; Base Sequence; Benzo(a)pyrene; beta-Naphthoflavone; Digestive System; DNA, Complementary; Exons; Gene Expression; Glucuronosyltransferase; Humans; Kidney; Liver; Male; Methylcholanthrene; Molecular Sequence Data; Promoter Regions, Genetic; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Alignment; Thiones; Thiophenes | 2001 |
Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: characterization and application to dosimetry and chemoprevention in rats.
Topics: Aflatoxins; Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; Chemoprevention; Chromatography, Liquid; Dose-Response Relationship, Drug; Male; Pyrazines; Rats; Rats, Inbred F344; Spectrometry, Mass, Electrospray Ionization; Spectrum Analysis; Thiones; Thiophenes | 2001 |
In vivo inhibition of human CYP1A2 activity by oltipraz.
Topics: Adult; Antineoplastic Agents; Caffeine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Female; Humans; Male; Methylation; Pyrazines; Theophylline; Thiones; Thiophenes | 2001 |
Effect of chemopreventive agents on DNA adduction induced by the potent mammary carcinogen dibenzo[a,l]pyrene in the human breast cells MCF-7.
Topics: Anticarcinogenic Agents; Antimutagenic Agents; Antineoplastic Agents; Benzopyrenes; Breast; Breast Neoplasms; Carcinogens; Cell Line; Chemoprevention; Chlorophyllides; DNA Adducts; Dose-Response Relationship, Drug; Female; Humans; Pyrazines; Thiones; Thiophenes | 2001 |
Kinetic constraints for the thiolysis of 4-methyl-5-(pyrazin-2-yl)-1,2-dithiole-3-thione (oltipraz) and related dithiole-3-thiones in aqueous solution.
Topics: Anticarcinogenic Agents; Hydrogen-Ion Concentration; Kinetics; Pyrazines; Sulfhydryl Compounds; Temperature; Thiones; Thiophenes; Toluene; Water | 2001 |
The chemopreventive agent oltipraz possesses potent antiangiogenic activity in vitro, ex vivo, and in vivo and inhibits tumor xenograft growth.
Topics: Angiogenesis Inhibitors; Animals; Anticarcinogenic Agents; Cell Division; Dose-Response Relationship, Drug; Endothelium, Vascular; Hemangiosarcoma; Humans; Insulin-Like Growth Factor I; Liver; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Pyrazines; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Fibroblast Growth Factor, Type 4; Receptors, Fibroblast Growth Factor; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Ribonuclease, Pancreatic; Thiones; Thiophenes; Transplantation, Heterologous; Tumor Cells, Cultured | 2002 |
Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-beta1 and tumor necrosis factor-alpha expression.
Topics: Animals; Base Sequence; Dimethylnitrosamine; DNA Primers; Glyceraldehyde-3-Phosphate Dehydrogenases; Liver Cirrhosis, Experimental; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiones; Thiophenes; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2002 |
Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases.
Topics: Acetaminophen; Analgesics; Animals; Blotting, Western; Catalysis; Cells, Cultured; Chromatography, High Pressure Liquid; Enzyme Induction; Glucuronosyltransferase; Hepatocytes; Humans; In Vitro Techniques; Kinetics; Male; Microsomes, Liver; Molecular Sequence Data; Pyrazines; Rats; Rats, Gunn; Rats, Sprague-Dawley; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Thiones; Thiophenes | 2002 |
[Studies on apoptosis of human lung adenocarcinoma cells induced by oltipraz].
Topics: Adenocarcinoma; Anticarcinogenic Agents; Apoptosis; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mitosis; Pyrazines; Thiones; Thiophenes; Tumor Cells, Cultured | 1999 |
Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent.
Topics: Animals; Anticarcinogenic Agents; Base Sequence; Caco-2 Cells; Colonic Neoplasms; Cytochrome P-450 CYP1A1; DNA Primers; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Male; Molecular Sequence Data; Promoter Regions, Genetic; Pyrazines; Rats; Rats, Wistar; Receptors, Aryl Hydrocarbon; RNA, Messenger; Thiones; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Investigations on the effects of oltipraz on the nucleotide excision repair in the liver.
Topics: Aflatoxin B1; Animals; DNA; DNA Adducts; DNA Repair; Hepatocytes; Humans; Liver; Male; Pyrazines; Rats; Rats, Wistar; Reverse Transcriptase Inhibitors; Thiones; Thiophenes | 2002 |
Oltipraz protects the passive smoke induced changes in renal glyoxalase system of rats.
Topics: Animals; Anticarcinogenic Agents; Female; Kidney; Lactoylglutathione Lyase; Neoplasms; Pyrazines; Rats; Rats, Sprague-Dawley; Thiolester Hydrolases; Thiones; Thiophenes; Tobacco Smoke Pollution | 2002 |
Cell-based studies reveal differences in glutathione S-transferase induction between oltipraz and tert-butylhydroquinone.
Topics: Animals; Blotting, Northern; Enzyme Induction; Glutathione Transferase; Hydroquinones; Luciferases; Plasmids; Promoter Regions, Genetic; Pyrazines; Rats; RNA, Messenger; Thiones; Thiophenes; Tumor Cells, Cultured | 2002 |
Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation.
Topics: Animals; CCAAT-Enhancer-Binding Proteins; Extracellular Matrix; Liver; Liver Cirrhosis, Experimental; Liver Regeneration; Models, Biological; Pyrazines; Rats; RNA, Messenger; Survival Analysis; Thiones; Thiophenes; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2002 |
Protection of retinal pigment epithelial cells from oxidative damage by oltipraz, a cancer chemopreventive agent.
Topics: Anticarcinogenic Agents; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Cytoprotection; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Humans; L-Lactate Dehydrogenase; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Pigment Epithelium of Eye; Pyrazines; Reactive Oxygen Species; tert-Butylhydroperoxide; Thiones; Thiophenes | 2002 |
The anti-fibrogenic effect of a pharmaceutical composition of [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB).
Topics: Animals; Drug Combinations; Hydrocarbons, Chlorinated; Liver Cirrhosis; Pharmaceutical Preparations; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2002 |
Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones.
Topics: 3T3 Cells; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Base Sequence; beta-Naphthoflavone; Blotting, Northern; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Ferritins; Gene Deletion; Genes, Reporter; Humans; Iron; Mice; Models, Biological; Models, Genetic; Molecular Sequence Data; NF-E2-Related Factor 2; Plasmids; Protein Binding; Protein Structure, Tertiary; Pyrazines; Response Elements; Thiones; Thiophenes; Time Factors; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Xenobiotics | 2003 |
Inhibition of mitogen-activated protein kinase activity of human lymphocytes after oral administration of Oltipraz.
Topics: Administration, Oral; Adult; Anticarcinogenic Agents; Blotting, Western; Enzyme Inhibitors; Female; Humans; Lung Neoplasms; Lymphocytes; Male; MAP Kinase Signaling System; Middle Aged; Phosphorylation; Pyrazines; Signal Transduction; Thiones; Thiophenes | 2002 |
Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathway.
Topics: Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Binding Sites; Cells, Cultured; DNA-Binding Proteins; Glucuronosyltransferase; Hepatocytes; Humans; Monosaccharide Transport Proteins; Nuclear Proteins; Pyrazines; Rats; Receptors, Aryl Hydrocarbon; Thiones; Thiophenes; Transcription Factors; Transcription, Genetic; Xenobiotics | 2003 |
Thiolytic chemistry of alternative precursors to the major metabolite of the cancer chemopreventive oltipraz.
Topics: Algorithms; Anticarcinogenic Agents; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Kinetics; Models, Molecular; Molecular Structure; Pyrazines; Sulfhydryl Compounds; Thiones; Thiophenes | 2002 |
[Studies on inhibition of human lung carcinogenesis in early stage by oltipraz and its effects on some gene expression and regulation].
Topics: Anticarcinogenic Agents; Apoptosis; Cell Transformation, Neoplastic; Cells, Cultured; Fetus; Gene Expression Regulation, Neoplastic; Humans; Lung; Proto-Oncogene Proteins c-fos; Pyrazines; Tars; Thiones; Thiophenes | 1998 |
Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz.
Topics: Animals; Anticarcinogenic Agents; Bacterial Proteins; Blotting, Northern; Carrier Proteins; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Electrophoretic Mobility Shift Assay; Enzyme Induction; Gene Deletion; Gene Expression Regulation, Enzymologic; Genes, Reporter; Glutathione Transferase; Hepatocytes; Immunoblotting; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Luciferases; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Pyrazines; Rats; Rats, Inbred Strains; RNA, Messenger; Thiones; Thiophenes; Transfection; Translocation, Genetic; Up-Regulation | 2003 |
Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice.
Topics: Animals; Anticarcinogenic Agents; Benzo(a)pyrene; DNA Adducts; DNA-Binding Proteins; Genotype; Mice; Mice, Knockout; NF-E2-Related Factor 2; Pyrazines; Thiones; Thiophenes; Trans-Activators | 2003 |
Induction of NAD(P)H quinone: oxidoreductase1 inhibits carcinogen-induced aberrant crypt foci in colons of Sprague-Dawley rats.
Topics: Animals; Anticarcinogenic Agents; Carcinogens; Colon; Colonic Neoplasms; Dimethyl Fumarate; Disease Models, Animal; Enzyme Induction; Fumarates; Glucuronosyltransferase; Glutathione Transferase; Inactivation, Metabolic; Intestinal Mucosa; Liver; Male; NAD(P)H Dehydrogenase (Quinone); NADP; Pyrazines; Radiation-Sensitizing Agents; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2003 |
Role of the AP-1 element and redox factor-1 (Ref-1) in mediating transcriptional induction of DT-diaphorase gene expression by oltipraz: a target for chemoprevention.
Topics: Anticarcinogenic Agents; Carbon-Oxygen Lyases; Chemoprevention; DNA-(Apurinic or Apyrimidinic Site) Lyase; Gene Expression; HT29 Cells; Humans; NAD(P)H Dehydrogenase (Quinone); Promoter Regions, Genetic; Pyrazines; RNA, Messenger; Thiones; Thiophenes; Transcription Factor AP-1; Transcription, Genetic | 2003 |
Oltipraz is a bifunctional inducer activating both phase I and phase II drug-metabolizing enzymes via the xenobiotic responsive element.
Topics: Animals; Anticarcinogenic Agents; Base Sequence; DNA; Enzyme Activation; Glutathione Transferase; Inactivation, Metabolic; Molecular Sequence Data; Pyrazines; Rats; Thiones; Thiophenes; Xenobiotics | 2003 |
Stability, blood partition and protein binding of an antifibrotic agent, oltipraz.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Humans; Protein Binding; Pyrazines; Rabbits; Rats; Schistosomicides; Serum Albumin; Thiones; Thiophenes | 2001 |
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.
Topics: Acetaminophen; Allyl Compounds; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Bile; Blotting, Western; Branched DNA Signal Amplification Assay; Drug Resistance, Multiple; Kidney; Liver; Male; Mitochondrial Proteins; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; Ribosomal Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins; Stilbenes; Sulfides; Thiones; Thiophenes; Time Factors | 2003 |
Oltipraz inhibits 3-methylcholanthrene induction of CYP1A1 by CCAAT/enhancer-binding protein activation.
Topics: Animals; Anticarcinogenic Agents; Binding Sites; Blotting, Western; CCAAT-Enhancer-Binding Proteins; Cell Line; Cytochrome P-450 CYP1A1; DNA; Gene Expression; Genes, Reporter; Hepatocytes; Luciferases; Methylcholanthrene; Mutation; Promoter Regions, Genetic; Pyrazines; Rats; Receptors, Aryl Hydrocarbon; Recombinant Fusion Proteins; Thiones; Thiophenes; Transcriptional Activation; Transfection | 2003 |
Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz.
Topics: Aflatoxin B1; Animals; Anticarcinogenic Agents; Antioxidants; Blotting, Western; Carcinogens; DNA; DNA Adducts; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Immunoblotting; Liver; Male; Models, Chemical; Neoplasms; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Pyrazines; Rats; Rats, Inbred F344; RNA; RNA, Messenger; Temperature; Thiones; Thiophenes; Time Factors | 2003 |
Pharmacokinetic interaction between oltipraz and dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) after single intravenous and oral administration to rats.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Area Under Curve; Biphenyl Compounds; Dicarboxylic Acids; Drug Interactions; Injections, Intravenous; Male; Metabolic Clearance Rate; Protective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Tissue Distribution | 2003 |
Phase 2 enzyme induction by the major metabolite of oltipraz.
Topics: Animals; Blotting, Western; Cell Death; DNA-Binding Proteins; Enzyme Induction; Glutathione; Glutathione Transferase; Heme Oxygenase (Decyclizing); Luciferases; Methylation; Mice; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Prodrugs; Pyrazines; Pyrroles; Thiones; Thiophenes; Time Factors; Trans-Activators; Transcription Factors; Transfection; Tumor Cells, Cultured | 2003 |
Oltipraz inhibits inducible nitric oxide synthase in vitro and inhibits nitric oxide production in activated microglial cells.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Mice; Microglia; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pyrazines; Thiones; Thiophenes | 2004 |
NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.
Topics: Anticarcinogenic Agents; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cytosol; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Dominant; Genes, Reporter; Humans; I-kappa B Kinase; MAP Kinase Kinase Kinase 3; MAP Kinase Kinase Kinases; NAD(P)H Dehydrogenase (Quinone); NF-kappa B; NF-kappaB-Inducing Kinase; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Serine-Threonine Kinases; Proteins; Pyrazines; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Signal Transduction; Thiones; Thiophenes; Time Factors; Transcriptional Activation; Transfection | 2004 |
In vitro effect of low concentrations of oltipraz on the antioxidant defence of mouse hepatocytes and Schistosoma mansoni worms.
Topics: Animals; Cells, Cultured; Hepatocytes; Mice; Oxidative Stress; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes | 2004 |
Pharmacokinetic changes of oltipraz after intravenous and oral administration to rats with liver cirrhosis induced by dimethylnitrosamine.
Topics: Administration, Oral; Animals; Area Under Curve; Blood Proteins; Dimethylnitrosamine; Injections, Intravenous; Liver Cirrhosis, Experimental; Male; Microsomes, Liver; Protein Binding; Pyrazines; Rats; Rats, Sprague-Dawley; Schistosomicides; Thiones; Thiophenes; Time Factors; Tissue Distribution | 2004 |
Ceramide negatively regulates glutathione S-transferase gene transactivation via repression of hepatic nuclear factor-1 that is degraded by the ubiquitin proteasome system.
Topics: Animals; Cell Line; Ceramides; Cysteine Endopeptidases; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Gene Silencing; Glutathione Transferase; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hydroquinones; Multienzyme Complexes; Nuclear Proteins; Proteasome Endopeptidase Complex; Pyrazines; Rats; Thiones; Thiophenes; Transcription Factors; Transcriptional Activation; Ubiquitin | 2004 |
Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.
Topics: Animals; Antineoplastic Agents; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Eflornithine; Estradiol; Male; Models, Animal; Prostatic Intraepithelial Neoplasia; Prostatic Neoplasms; Pyrazines; Rats; Rats, Inbred Strains; Testosterone; Thiones; Thiophenes; Time Factors | 2004 |
Effects of acute renal failure on the pharmacokinetics of oltipraz in rats.
Topics: Acute Kidney Injury; Animals; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2004 |
Ceramide, an apoptotic rheostat, inhibits CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 activation: the role in glutathione S-transferase A2 gene repression.
Topics: Animals; Apoptosis; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Ceramides; DNA-Binding Proteins; Gene Silencing; Glutathione Transferase; Hepatocytes; Hydroquinones; Isoenzymes; NF-E2-Related Factor 2; Pyrazines; Rats; Sphingolipids; Thiones; Thiophenes; Trans-Activators | 2004 |
Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis.
Topics: Animals; Anticarcinogenic Agents; Butylhydroxybutylnitrosamine; Carcinogens; DNA-Binding Proteins; Enzyme Induction; Female; Gene Expression; Genetic Predisposition to Disease; Glucuronides; Glucuronosyltransferase; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Microsomes, Liver; NF-E2-Related Factor 2; Pyrazines; Thiones; Thiophenes; Trans-Activators; Urinary Bladder; Urinary Bladder Neoplasms | 2004 |
Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells.
Topics: Animals; Antioxidants; Blotting, Western; Cell Line; Cells, Cultured; DNA, Complementary; Hydrogen Peroxide; Isothiocyanates; Lipopolysaccharides; Mice; Microglia; Microscopy, Fluorescence; Oligonucleotide Array Sequence Analysis; Oxidants; Oxidative Stress; Pyrazines; Reactive Oxygen Species; RNA; Stimulation, Chemical; Sulfoxides; Thiocyanates; Thiones; Thiophenes | 2004 |
Oltipraz regulates different categories of genes relevant to chemoprevention in human hepatocytes.
Topics: Anticarcinogenic Agents; Chemoprevention; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hepatocytes; Humans; Pyrazines; RNA, Messenger; Thiones; Thiophenes | 2005 |
Pharmacokinetics of oltipraz after intravenous and oral administration in rats with dehydration for 72 hours.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Area Under Curve; Blood Proteins; Gastrointestinal Tract; Injections, Intravenous; Intestinal Absorption; Male; Metabolic Clearance Rate; Protein Binding; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Time Factors; Water Deprivation | 2005 |
Cancer chemopreventive oltipraz generates superoxide anion radical.
Topics: Antineoplastic Agents; Cell Line; Chemoprevention; Dose-Response Relationship, Drug; Free Radicals; Humans; Kidney; Oxygen; Pyrazines; Superoxides; Thiones; Thiophenes | 2005 |
Interspecies pharmacokinetic scaling of oltipraz in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics.
Topics: Administration, Oral; Animals; Area Under Curve; Dogs; Half-Life; Humans; Injections, Intravenous; Metabolic Clearance Rate; Mice; Predictive Value of Tests; Pyrazines; Rabbits; Rats; Species Specificity; Thiones; Thiophenes; Tissue Distribution | 2005 |
Hepatic and intestinal first-pass effects of oltipraz in rats.
Topics: Administration, Oral; Animals; Bile; Biological Availability; Duodenum; Gastric Mucosa; Injections, Intravenous; Intestinal Mucosa; Liver; Male; Metabolic Clearance Rate; Portal Vein; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Tissue Distribution | 2005 |
Effect of enzyme inducers and inhibitors on the pharmacokinetics of oltipraz in rats.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Isoenzymes; Isoniazid; Male; Metabolic Clearance Rate; Methylcholanthrene; Microsomes, Liver; Models, Animal; Phenobarbital; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes | 2005 |
Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells.
Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Biological Transport; Caco-2 Cells; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Dose-Response Relationship, Drug; Enzyme Induction; Flavones; Gene Expression; Humans; Indoles; Pyrazines; RNA, Messenger; Sulfates; Thiones; Thiophenes | 2005 |
Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzo(a)pyrene; Biological Transport; Cell Line, Tumor; Colonic Neoplasms; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Kinetics; Neoplasm Proteins; Polychlorinated Dibenzodioxins; Pyrazines; Receptors, Aryl Hydrocarbon; Reserpine; RNA, Messenger; Thiones; Thiophenes | 2005 |
Effects of cysteine on the pharmacokinetics of oltipraz in rats with protein-calorie malnutrition.
Topics: Animals; Chromatography, High Pressure Liquid; Cysteine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Microsomes, Liver; Protein-Energy Malnutrition; Pyrazines; Rats; Rats, Sprague-Dawley; Schistosomicides; Thiones; Thiophenes | 2005 |
Enhanced CCAAT/enhancer-binding protein beta-liver-enriched inhibitory protein production by Oltipraz, which accompanies CUG repeat-binding protein-1 (CUGBP1) RNA-binding protein activation, leads to inhibition of preadipocyte differentiation.
Topics: 3T3-L1 Cells; Adipocytes; Animals; CCAAT-Enhancer-Binding Protein-beta; CELF1 Protein; Cell Differentiation; Cell Nucleus; Mice; Pyrazines; RNA; RNA-Binding Proteins; Thiones; Thiophenes; Transcriptional Activation | 2005 |
Glutathione-mediated formation of oxygen free radicals by the major metabolite of oltipraz.
Topics: Animals; Anticarcinogenic Agents; Cattle; Electron Spin Resonance Spectroscopy; Glutathione; Pyrazines; Superoxides; Thiones; Thiophenes | 2005 |
Oltipraz-induced phase 2 enzyme response conserved in cells lacking mitochondrial DNA.
Topics: Anticarcinogenic Agents; Cell Line, Tumor; Cell Survival; DNA, Mitochondrial; Glutathione; Glutathione Transferase; Humans; Leukemia, Lymphoid; Membrane Potentials; Mitochondria; Oxidative Stress; Pyrazines; Reactive Oxygen Species; Thiones; Thiophenes | 2005 |
Role of p90 ribosomal S6-kinase-1 in oltipraz-induced specific phosphorylation of CCAAT/enhancer binding protein-beta for GSTA2 gene transactivation.
Topics: Amino Acid Sequence; Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Chromatin Immunoprecipitation; Glutathione Transferase; Humans; Isoenzymes; Mice; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphorylation; Pyrazines; Rats; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Small Interfering; Sequence Homology, Amino Acid; Serine; Thiones; Thiophenes; Transcriptional Activation; Transfection | 2006 |
Pharmacokinetics of oltipraz in rat models of diabetes mellitus induced by alloxan or streptozotocin.
Topics: Administration, Oral; Alloxan; Animals; Blood Proteins; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Half-Life; Injections, Intravenous; Male; Microsomes, Liver; Protein Binding; Pyrazines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin; Thiones; Thiophenes | 2006 |
The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells.
Topics: Active Transport, Cell Nucleus; Animals; Cells, Cultured; DNA; Enzyme Induction; Ethacrynic Acid; Extracellular Signal-Regulated MAP Kinases; HMGB1 Protein; Interleukin-10; Interleukin-6; Isothiocyanates; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Phosphorylation; Pyrazines; Sulfoxides; Thiocyanates; Thiones; Thiophenes; Tumor Necrosis Factor-alpha | 2006 |
Sample size and statistical power assessing the effect of interventions in the context of mixture distributions with detection limits.
Topics: Aflatoxin M1; Cohort Studies; Computer Simulation; Drug Evaluation; Food Contamination; Humans; Models, Statistical; Monte Carlo Method; Pyrazines; Randomized Controlled Trials as Topic; Sample Size; Sensitivity and Specificity; Thiones; Thiophenes | 2006 |
Structure-activity relationships in the induction of Phase II enzymes by derivatives of 3H-1,2-dithiole-3-thione in rats.
Topics: Animals; Antineoplastic Agents; Enzyme Induction; Female; Glutathione Transferase; Metabolic Detoxication, Phase II; NAD(P)H Dehydrogenase (Quinone); Pyrazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiones; Thiophenes | 2006 |
Pharmacokinetics of oltipraz in mutant Nagase analbuminemic rats.
Topics: Acetylglucosaminidase; Administration, Oral; Albumins; Animals; Area Under Curve; Blood Proteins; Cytochrome P-450 CYP1A2; Dialysis; Half-Life; Injections, Intravenous; Male; Microsomes, Liver; Mutation; Protein Binding; Pyrazines; Rats; Rats, Sprague-Dawley; Schistosomicides; Thiones; Thiophenes | 2006 |
Pharmacokinetics and therapeutic effects of oltipraz after consecutive or intermittent oral administration in rats with liver cirrhosis induced by dimethylnitrosamine.
Topics: Administration, Oral; Alkylating Agents; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Creatinine; Dimethylnitrosamine; Half-Life; Hematocrit; Liver; Liver Cirrhosis; Male; Organ Size; Pyrazines; Rats; Rats, Wistar; Schistosomicides; Thiones; Thiophenes | 2006 |
The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Benzo(a)pyrene; Female; Inhalation; Lung Neoplasms; Mice; Mice, Inbred A; Pyrazines; Thiones; Thiophenes | 2006 |
Differential effects of the oxidized metabolites of oltipraz on the activation of CCAAT/enhancer binding protein-beta and NF-E2-related factor-2 for GSTA2 gene induction.
Topics: Animals; Anticarcinogenic Agents; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Enzyme Induction; Gene Expression; Glutathione Transferase; Isoenzymes; NF-E2-Related Factor 2; Pyrazines; Rats; Thiones; Thiophenes | 2006 |
Induction of antioxidant genes in the brain as a therapeutic target in bipolar disorder: potential role of oltipraz.
Topics: Antioxidants; Bipolar Disorder; Brain; Gene Expression; Humans; Models, Biological; Multigene Family; Pyrazines; Thiones; Thiophenes; Transcriptional Activation | 2006 |
A general approach for sample size and statistical power calculations assessing of interventions using a mixture model in the presence of detection limits.
Topics: Anticarcinogenic Agents; Clinical Trials as Topic; Computer Simulation; Humans; Models, Statistical; Monte Carlo Method; Neoplasms; Pyrazines; Sample Size; Thiones; Thiophenes | 2006 |
Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Constitutive Androstane Receptor; Gene Expression Regulation; Hepatocytes; Humans; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; NF-E2-Related Factor 2; Phenobarbital; Polychlorinated Dibenzodioxins; Pregnane X Receptor; Pyrazines; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Drug; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA, Messenger; Symporters; Thiones; Thiophenes; Transcription Factors; Xenobiotics | 2006 |
The induction of CYP1A1 by oltipraz is mediated through calcium-dependent-calpain.
Topics: Animals; Anticarcinogenic Agents; Calcium; Calpain; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Down-Regulation; Enzyme Induction; Female; Humans; Immunohistochemistry; Mice; Microscopy, Fluorescence; Pyrazines; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; Thiones; Thiophenes | 2006 |
Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines.
Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Base Sequence; Biological Products; Blotting, Western; Cell Line, Tumor; Curcumin; Cysteine; DNA Modification Methylases; DNA Primers; DNA Repair Enzymes; Dose-Response Relationship, Drug; Fenretinide; Glutathione; Glutathione S-Transferase pi; Humans; Lymphocytes; Prodrugs; Pyrazines; RNA, Messenger; Silymarin; Thiones; Thiophenes; Tumor Suppressor Protein p14ARF; Tumor Suppressor Proteins | 2007 |
Inhibition of TGFbeta1-mediated PAI-1 induction by oltipraz through selective interruption of Smad 3 activation.
Topics: Active Transport, Cell Nucleus; Animals; Antiviral Agents; Cell Line; Cell Nucleus; Humans; Liver Cirrhosis; Mice; Plasminogen Activator Inhibitor 1; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Transforming Growth Factor beta; Signal Transduction; Smad Proteins; Thiones; Thiophenes; Transforming Growth Factor beta1 | 2006 |
Oltipraz may be useful in the prevention or treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Humans; Mice; Neurodegenerative Diseases; Oxidative Stress; Pyrazines; Schistosomicides; Thiones; Thiophenes | 2007 |
Oxidative and electrophilic stress induces multidrug resistance-associated protein transporters via the nuclear factor-E2-related factor-2 transcriptional pathway.
Topics: 5' Flanking Region; Animals; Antioxidants; Butylated Hydroxyanisole; Cell Line, Tumor; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Glutamate-Cysteine Ligase; Glutathione; Hepatocytes; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Oxidative Stress; Promoter Regions, Genetic; Pyrazines; Reverse Transcriptase Inhibitors; Thiones; Thiophenes | 2007 |
Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Glucose; Hypoglycemia; Insulin; Insulin Resistance; Leptin; Liver; Mice; Mice, Mutant Strains; Multienzyme Complexes; Phosphorylation; Protein Serine-Threonine Kinases; Pyrazines; Ribosomal Protein S6 Kinases, 70-kDa; Thiones; Thiophenes; Transfection; Transforming Growth Factor alpha | 2007 |
Interactions of the major metabolite of the cancer chemopreventive drug oltipraz with cytochrome c: a novel pathway for cancer chemoprevention.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Chemoprevention; Cytochromes c; Electron Spin Resonance Spectroscopy; Electron Transport; Heart; Horses; Mass Spectrometry; Mitochondria; Neoplasms; Oxidation-Reduction; Peroxidase; Pyrazines; Reactive Oxygen Species; Spectrophotometry, Ultraviolet; Thiones; Thiophenes | 2007 |
Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?
Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Dihydralazine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Models, Biological; NADP; Paroxetine; Pyrazines; Resveratrol; Stilbenes; Theophylline; Thiones; Thiophenes | 2007 |
Pharmacokinetic interaction between oltipraz and omeprazole in rats: Competitive inhibition of metabolism of oltipraz by omeprazole via CYP1A1 and 3A2, and of omeprazole by oltipraz via CYP1A1/2, 2D1/2, and 3A1/2.
Topics: Administration, Oral; Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Binding, Competitive; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P450 Family 2; Cytochromes; Drug Interactions; Enzyme Inhibitors; Injections, Intravenous; Intestine, Small; Liver; Male; Membrane Proteins; Microsomes; Omeprazole; Pyrazines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiones; Thiophenes; Time Factors; Tissue Distribution | 2007 |
Minimal role of hepatic transporters in the hepatoprotection against LCA-induced intrahepatic cholestasis.
Topics: Animals; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cholestasis, Intrahepatic; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; Organic Anion Transporters; Organic Anion Transporters, Sodium-Dependent; Phenobarbital; Protective Agents; Pyrazines; Pyridines; RNA, Messenger; Symporters; Thiones; Thiophenes; Time Factors; Up-Regulation | 2008 |
A Bayesian approach estimating treatment effects on biomarkers containing zeros with detection limits.
Topics: Aflatoxin M1; Bayes Theorem; Biomarkers; Computer Simulation; Data Interpretation, Statistical; Humans; Markov Chains; Monte Carlo Method; Pyrazines; Thiones; Thiophenes | 2008 |
Abrogation of hyperosmotic impairment of insulin signaling by a novel class of 1,2-dithiole-3-thiones through the inhibition of S6K1 activation.
Topics: Adaptor Proteins, Signal Transducing; Adipocytes; Animals; Cell Line; Enzyme Activation; Glucose; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Insulin; Insulin Receptor Substrate Proteins; Mice; Muscle Fibers, Skeletal; Mutant Proteins; Osmotic Pressure; Phosphorylation; Phosphoserine; Pyrazines; Ribosomal Protein S6 Kinases; Signal Transduction; Thiones; Thiophenes; Tumor Necrosis Factor-alpha | 2008 |
The Nrf2 activator oltipraz also activates the constitutive androstane receptor.
Topics: Animals; Blotting, Western; Cell Line; Constitutive Androstane Receptor; Cytochrome P-450 Enzyme System; Enzyme Induction; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; NF-E2-Related Factor 2; Pyrazines; Receptors, Cytoplasmic and Nuclear; Thiones; Thiophenes; Transcription Factors; Transcription, Genetic | 2008 |
Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners.
Topics: Apoptosis; Arachidonic Acid; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Formazans; Humans; In Situ Nick-End Labeling; Iron; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Pyrazines; Reactive Oxygen Species; Tetrazolium Salts; Thiones; Thiophenes; Time Factors | 2009 |
Chemical genomics of cancer chemopreventive dithiolethiones.
Topics: Animals; Anticarcinogenic Agents; Cytochrome P-450 CYP1A2; Gene Expression Profiling; Genomics; Glutathione; Heterocyclic Compounds, 1-Ring; Liver; Male; Multigene Family; NF-E2-Related Factor 2; Oligonucleotide Array Sequence Analysis; Pyrazines; Rats; Rats, Inbred F344; Structure-Activity Relationship; Thiones; Thiophenes | 2009 |
Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Basic-Leucine Zipper Transcription Factors; Cell Line, Tumor; Citrus; Coumarins; Cytosol; Female; Glutathione Transferase; Green Fluorescent Proteins; Humans; Liver; Male; Mice; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NADPH Dehydrogenase; Pyrazines; Response Elements; Thiones; Thiophenes; Transfection | 2009 |
Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis.
Topics: Animals; Area Under Curve; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Liver; Liver Cirrhosis, Experimental; Pyrazines; Rats; Schistosomicides; Thiones; Thiophenes | 2009 |
Role of hepatitis B virus X repression of C/EBPbeta activity in the down-regulation of glutathione S-transferase A2 gene: implications in other phase II detoxifying enzyme expression.
Topics: Animals; Binding Sites; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Down-Regulation; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Repression; Gene Expression; Gene Expression Profiling; Glutathione Transferase; Humans; Isoenzymes; Liver; Metabolic Detoxication, Phase II; Mice; Mice, Transgenic; NF-E2-Related Factor 2; Promoter Regions, Genetic; Pyrazines; Rats; Thiones; Thiophenes; Trans-Activators; Transcriptional Activation; Viral Regulatory and Accessory Proteins | 2009 |
Oxidized metabolites of oltipraz exert cytoprotective effects against arachidonic acid through AMP-activated protein kinase-dependent cellular antioxidant effect and mitochondrial protection.
Topics: AMP-Activated Protein Kinases; Antioxidants; Apoptosis; Arachidonic Acid; Cytoprotection; Drug Antagonism; Membrane Potential, Mitochondrial; Mitochondria; Pyrazines; Reactive Oxygen Species; Thiones; Thiophenes; Tumor Cells, Cultured | 2009 |
Role of adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway in repression of liver X receptor-alpha-dependent lipogenic gene induction and hepatic steatosis by a novel class of dithiolethiones.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Fatty Liver; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Orphan Nuclear Receptors; Pyrazines; Receptors, Cytoplasmic and Nuclear; Ribosomal Protein S6 Kinases, 70-kDa; Sterol Regulatory Element Binding Protein 1; Thiones; Thiophenes; Transcriptional Activation | 2009 |
This month in APR.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Proliferation; Cyclin E; Dose-Response Relationship, Drug; Hepatectomy; Hepatocyte Growth Factor; Humans; Liver; Liver Cirrhosis; Liver Regeneration; Phosphatidylinositol 3-Kinases; Pyrazines; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Thiones; Thiophenes; Time Factors | 2009 |
Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPbeta and cyclin E regulation.
Topics: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Line; Cell Proliferation; Cyclin E; Dose-Response Relationship, Drug; Hepatectomy; Hepatocyte Growth Factor; Liver; Liver Regeneration; Male; Models, Animal; Mutation; Phosphatidylinositol 3-Kinases; Pyrazines; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Thiones; Thiophenes; Time Factors; Transfection | 2009 |
Inhibition of colon carcinogenesis by post-initiation induction of NQO1 in Sprague-Dawley rats.
Topics: Adenoma; Animals; Anticarcinogenic Agents; Apoptosis; Azoxymethane; Cell Transformation, Neoplastic; Colon; Colonic Neoplasms; Enzyme Induction; Glucuronosyltransferase; Glutathione Transferase; Intestinal Mucosa; Male; NAD(P)H Dehydrogenase (Quinone); Neoplasms, Experimental; Precancerous Conditions; Pyrazines; Rats; Rats, Sprague-Dawley; Thiones; Thiophenes; Time Factors | 2009 |
Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Cholestasis, Intrahepatic; Constitutive Androstane Receptor; Cytoprotection; Disease Models, Animal; Lithocholic Acid; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cell Leukemia Sequence 1 Protein; Phenobarbital; Pregnenolone Carbonitrile; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Pyridines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiones; Thiophenes; Transcription Factors | 2009 |
Pharmacokinetic interaction between oltipraz and silymarin in rats.
Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Area Under Curve; Drug Interactions; Injections, Intravenous; Male; Metabolic Clearance Rate; Microsomes, Liver; Pyrazines; Rats; Rats, Sprague-Dawley; Silybin; Silymarin; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Thiones; Thiophenes; Tissue Distribution | 2009 |
Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cyclic N-Oxides; Diglycerides; Enzyme Induction; Hepatocytes; Humans; Hydrogen Peroxide; NAD(P)H Dehydrogenase (Quinone); Neoplasms; Pyrazines; Second Messenger Systems; Thiones; Thiophenes | 2009 |
Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect.
Topics: Adenylate Kinase; Animals; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Free Radical Scavengers; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Mice; Neovascularization, Pathologic; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Protein Stability; Pyrazines; Ribosomal Protein S6 Kinases, 70-kDa; Thiones; Thiophenes; Transcription, Genetic; Ubiquitin | 2009 |
Parasitological and histo-pathological studies on schistosomiasis mansoni infected mice and treated with praziquatel and/or oltipraz.
Topics: Animals; Drug Therapy, Combination; Humans; Liver; Male; Mice; Parasite Egg Count; Praziquantel; Pyrazines; Random Allocation; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes; Treatment Outcome | 2009 |
Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Base Sequence; Hep G2 Cells; Hepatocytes; Humans; Maf Transcription Factors; Molecular Sequence Data; NF-E2-Related Factor 2; Pyrazines; Reverse Transcriptase Inhibitors; RNA, Messenger; Signal Transduction; Thiones; Thiophenes | 2009 |
Involvement of pregnane X receptor in the regulation of CYP2B6 gene expression by oltipraz in human hepatocytes.
Topics: Anticarcinogenic Agents; Aryl Hydrocarbon Hydroxylases; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 CYP2B6; Gene Expression Regulation; Hepatocytes; Humans; Hydroxylation; Liver Neoplasms; Oxidoreductases, N-Demethylating; Pregnane X Receptor; Pyrazines; Receptors, Steroid; RNA, Messenger; Testosterone; Thiones; Thiophenes | 2010 |
Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs.
Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; beta-Naphthoflavone; Chemoprevention; Cluster Analysis; Enzyme Inhibitors; Gene Expression; Indoles; Isothiocyanates; Lung; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Thiones; Thiophenes; Tobacco Smoke Pollution | 2010 |
Nuclear factor erythroid 2-related factor 2 deletion impairs glucose tolerance and exacerbates hyperglycemia in type 1 diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Glucose Intolerance; Glucose-6-Phosphatase; Hyperglycemia; Insulin; Liver; Liver Glycogen; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Pancreas; Phosphoenolpyruvate Carboxykinase (GTP); Pyrazines; Pyruvate Kinase; RNA, Messenger; Thiones; Thiophenes; Urodynamics | 2010 |
Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.
Topics: 5' Flanking Region; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Butylamines; Chromatin Immunoprecipitation; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Genes, Reporter; Hep G2 Cells; Hepatocytes; Humans; Methylcholanthrene; Mice; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutation; NF-E2-Related Factor 2; Polychlorinated Dibenzodioxins; Promoter Regions, Genetic; Pyrazines; Receptors, Aryl Hydrocarbon; Response Elements; RNA Interference; RNA, Messenger; Thiones; Thiophenes; Time Factors; Transfection | 2010 |
Inactivation of protein tyrosine phosphatases by oltipraz and other cancer chemopreventive 1,2-dithiole-3-thiones.
Topics: Anticarcinogenic Agents; Catalytic Domain; Humans; Mass Spectrometry; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrazines; Reactive Oxygen Species; Recombinant Proteins; Thiones; Thiophenes | 2010 |
Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 [corrected](NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice.
Topics: Animals; Antioxidants; Blotting, Western; Dietary Fats; Hep G2 Cells; Humans; Insulin Resistance; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Obesity; Oxidative Stress; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Thiones; Thiophenes | 2011 |
Quantification of oltipraz using liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study in rat plasma.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Pyrazines; Rats; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry; Thiones; Thiophenes | 2011 |
Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; HT29 Cells; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrazines; Pyridazines; Pyrroles; Thiones; Thiophenes | 2012 |
Handling the limit of detection by extrapolation.
Topics: Aflatoxin B1; Analysis of Variance; Biostatistics; Chemoprevention; Data Interpretation, Statistical; Humans; Limit of Detection; Linear Models; Models, Statistical; Pyrazines; Randomized Controlled Trials as Topic; Regression Analysis; Thiones; Thiophenes | 2012 |
Multi-layer polymeric implants for sustained release of chemopreventives.
Topics: Animals; Anticarcinogenic Agents; Biological Availability; Coated Materials, Biocompatible; Curcumin; DNA Adducts; Female; Humans; Infusion Pumps, Implantable; Mice; Mice, Nude; Polyesters; Polymers; Pyrazines; Thiones; Thiophenes; Tissue Distribution; Withanolides; Xenograft Model Antitumor Assays | 2012 |
An active metabolite of oltipraz (M2) increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Anticarcinogenic Agents; Antioxidants; Diet, High-Fat; Enzyme Activation; Fatty Liver; Hep G2 Cells; Humans; Lipid Metabolism; Lipogenesis; Liver; Liver X Receptors; Male; Mice; Mice, Inbred C57BL; Mitochondria; Orphan Nuclear Receptors; Oxidation-Reduction; Oxidative Stress; Pyrazines; Sterol Regulatory Element Binding Protein 1; Thiones; Thiophenes | 2013 |
The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anticarcinogenic Agents; Cytoskeletal Proteins; Disease Models, Animal; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Kelch-Like ECH-Associated Protein 1; Mice; Mice, Knockout; NF-E2-Related Factor 2; Pulmonary Disease, Chronic Obstructive; Pyrazines; Tenascin; Thiones; Thiophenes | 2013 |
Deleterious effect of oltipraz on extrahepatic cholestasis in bile duct-ligated mice.
Topics: Angiogenic Proteins; Animals; Bile; Bile Acids and Salts; Bile Ducts; Cholestasis, Extrahepatic; Glutathione; Ligation; Male; Mice; Mice, Inbred C57BL; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Pyrazines; Thiones; Thiophenes; Transforming Growth Factor beta | 2014 |
Time to say goodbye to the drug or the model? - why do drugs fail to live up to their promise in bile duct ligated mice?
Topics: Animals; Cholestasis, Extrahepatic; Male; Pyrazines; Thiones; Thiophenes | 2014 |
Catalase overexpression prevents nuclear factor erythroid 2-related factor 2 stimulation of renal angiotensinogen gene expression, hypertension, and kidney injury in diabetic mice.
Topics: Acute Kidney Injury; Angiotensinogen; Animals; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Gene Expression; Hypertension; Kidney Tubules, Proximal; Mice; Mice, Transgenic; NF-E2-Related Factor 2; NF-kappa B; Pyrazines; Reverse Transcriptase Inhibitors; Signal Transduction; Thiones; Thiophenes | 2014 |
Expression and functional regulation of the nuclear receptors AHR, PXR, and CAR, and the transcription factor Nrf2 in rat parotid gland.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Nucleus; Constitutive Androstane Receptor; Cytoplasm; Dexamethasone; Gene Expression Regulation; Male; NF-E2-Related Factor 2; Parotid Gland; Phenobarbital; Polychlorinated Dibenzodioxins; Pregnane X Receptor; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Salivary Ducts; Thiones; Thiophenes | 2014 |
Identification of heme oxygenase-1 stimulators by a convenient ELISA-based bilirubin quantification assay.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Bilirubin; Biological Assay; Blotting, Western; Cell Proliferation; Cells, Cultured; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Flavonoids; Heme Oxygenase-1; Macrophages; Mice; Pyrazines; Thiones; Thiophenes | 2015 |
Characterization of arsenic hepatobiliary transport using sandwich-cultured human hepatocytes.
Topics: Arsenic; Bile Ducts; Biological Transport; Cell Culture Techniques; Dose-Response Relationship, Drug; Glutathione; HEK293 Cells; Hepatocytes; Humans; Kinetics; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; NF-E2-Related Factor 2; Propionates; Pyrazines; Quinolines; Temperature; Thiones; Thiophenes; Transfection | 2015 |
Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor.
Topics: Antineoplastic Agents; Glucose Transporter Type 1; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Pyrazines; Thiones; Thiophenes; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2016 |
4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin.
Topics: Antineoplastic Agents; Bibenzyls; Cell Cycle; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; KB Cells; Molecular Docking Simulation; Protein Multimerization; Protein Structure, Quaternary; Pyrazines; Structure-Activity Relationship; Thiones; Thiophenes; Tubulin; Tubulin Modulators | 2016 |
The antioxidant transcription factor Nrf2 contributes to the protective effect of mild thermotolerance (40°C) against heat shock-induced apoptosis.
Topics: Apoptosis; Benzothiazoles; Catalase; Gene Expression Regulation; Glutamate-Cysteine Ligase; HeLa Cells; Heme Oxygenase-1; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; NF-E2-Related Factor 2; Polyethylene Glycols; Pyrazines; RNA, Small Interfering; Signal Transduction; Stress, Physiological; Superoxide Dismutase; Thermotolerance; Thiones; Thiophenes; Toluene; Tumor Suppressor Protein p53 | 2016 |
Letter: the efficacy of oltipraz in patients with non-alcoholic fatty liver disease has not been confirmed.
Topics: Fatty Liver; Humans; Liver; Liver Cirrhosis; Non-alcoholic Fatty Liver Disease; Pyrazines; Thiones; Thiophenes | 2017 |
Letter: the efficacy of oltipraz in patients with non-alcoholic fatty liver disease has not been confirmed-authors' reply.
Topics: Fatty Liver; Humans; Non-alcoholic Fatty Liver Disease; Pyrazines; Thiones; Thiophenes | 2017 |
Effects of simvastatin on nuclear receptors, drug metabolizing enzymes and transporters expression in Human Umbilical Vein Endothelial Cells.
Topics: ATP Binding Cassette Transporter, Subfamily B; Cells, Cultured; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Peroxisome-Targeting Signal 1 Receptor; Polychlorinated Dibenzodioxins; Pyrazines; Receptors, Aryl Hydrocarbon; Simvastatin; Thiones; Thiophenes | 2018 |
Oltipraz attenuates the progression of heart failure in rats through inhibiting oxidative stress and inflammatory response.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Cytokines; Disease Models, Animal; Fibrosis; Heart Failure; Inflammation Mediators; Isoproterenol; Myocytes, Cardiac; Oxidative Stress; Pyrazines; Rats, Sprague-Dawley; Recovery of Function; Thiones; Thiophenes; Ventricular Function, Left; Ventricular Remodeling | 2018 |
Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis.
Topics: Acute Kidney Injury; Animals; Antioxidants; Fibrosis; Mice; Nanoparticles; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Pyrazines; Reperfusion Injury; Thiones; Thiophenes; Time Factors; Tissue Distribution; Treatment Outcome | 2019 |
Acetaminophen-induced hepatocyte injury: C2-ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S-transferase A1 changes.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antioxidants; Cell Culture Techniques; Cell Proliferation; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Gene Expression; Glutathione Transferase; Hep G2 Cells; Hepatocyte Nuclear Factor 1; Hepatocytes; Humans; Pyrazines; Sphingosine; Thiones; Thiophenes | 2019 |
Comparative effectiveness of 4 natural and chemical activators of Nrf2 on inflammation, oxidative stress, macrophage polarization, and bactericidal activity in an in vitro macrophage infection model.
Topics: Anti-Inflammatory Agents; Antioxidants; Dimethyl Fumarate; Escherichia coli; Escherichia coli Infections; Flavanones; Humans; Inflammation; Isothiocyanates; Leukocytes, Mononuclear; Macrophage Activation; Macrophages; NF-E2-Related Factor 2; Oxidative Stress; Pyrazines; Staphylococcal Infections; Staphylococcus aureus; Sulfoxides; Thiones; Thiophenes; THP-1 Cells | 2020 |
Oltipraz Prevents High Glucose-Induced Oxidative Stress and Apoptosis in RSC96 Cells through the Nrf2/NQO1 Signalling Pathway.
Topics: Animals; Apoptosis; Cell Line; Diabetic Nephropathies; Glucose; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Pyrazines; Rats; Thiones; Thiophenes | 2020 |
Activation of Nrf2 signaling by oltipraz inhibits death of human macrophages with mycobacterium tuberculosis infection.
Topics: Apoptosis; Cytoprotection; Humans; Macrophages; Necrosis; NF-E2-Related Factor 2; Oxidative Stress; Pyrazines; Signal Transduction; Thiones; Thiophenes; Tuberculosis | 2020 |
Transcriptome and lipidome profile of human mesenchymal stem cells with reduced senescence and increased trilineage differentiation ability upon drug treatment.
Topics: Ascorbic Acid; Cell Differentiation; Cellular Senescence; Humans; Hypoglycemic Agents; Lipidomics; Mesenchymal Stem Cells; Metformin; Pyrazines; Reverse Transcriptase Inhibitors; Sirolimus; Thiones; Thiophenes; Transcriptome | 2021 |
Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1α/GSTA1 expression via JNK signaling pathway.
Topics: Chemical and Drug Induced Liver Injury; Glutathione Transferase; Hep G2 Cells; Hepatocyte Nuclear Factor 1-alpha; Humans; MAP Kinase Signaling System; Pyrazines; Sphingosine; Thiones; Thiophenes | 2021 |
Protective effect of oltipraz in testicular ischaemia/reperfusion injury: An experimental study.
Topics: Humans; Ischemia; Male; Malondialdehyde; Pyrazines; Rats; Reperfusion Injury; Spermatic Cord Torsion; Testis; Thiones; Thiophenes | 2022 |
Elucidating the Anti-Tumorigenic Efficacy of Oltipraz, a Dithiolethione, in Glioblastoma.
Topics: Animals; beta Catenin; Carcinogenesis; Caspase 3; Cell Line, Tumor; Glioblastoma; Glutathione; HEK293 Cells; Humans; Mice; Mice, SCID; Neoplastic Stem Cells; Nestin; Pyrazines; Reactive Oxygen Species; Thiones; Thiophenes; Vimentin | 2022 |