Page last updated: 2024-08-23

oltipraz and acetylcysteine

oltipraz has been researched along with acetylcysteine in 9 studies

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (22.22)	18.2507
2000's	4 (44.44)	29.6817
2010's	2 (22.22)	24.3611
2020's	1 (11.11)	2.80

Authors

Authors	Studies
Cai, S; Carter, AC; Cichewicz, RH; King, JB; Mattes, AO; Singh, N	1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M	1
Bagnasco, M; Bennicelli, C; Camoirano, A; De Flora, S; Kensler, TW; Qian, GS; van Zandwijk, N; Wigbout, G; Zhu, YR	1
Egner, PA; Groopman, JD; He, X; Helzlsouer, KJ; Jacobson, LP; Kensler, TW; Kuang, SY; Muñoz, A; Qian, GS; Shen, X; Wang, JB; Wang, JS; Zarba, A; Zhang, BC; Zhu, YR	1
Balansky, RM; Bennicelli, C; Dagostini, F; De Flora, S; Grubbs, CJ; Izzotti, A; Kelloff, GJ; Lubet, RA; Myers, SR	1
Bolanowska-Higdon, W; Creaven, PJ; Hitt, S; Lawrence, D; Murphy, M; Pendyala, L; Schwartz, G; Zdanowicz, J	1
Camoirano, A; Cartiglia, C; De Flora, S; Izzotti, A; Tampa, E	1
Bhat, GJ; Niture, SK; Smith, QR; Srivenugopal, KS; Velu, CS	1
Calin, GA; Cartiglia, C; Croce, CM; De Flora, S; Izzotti, A; Longobardi, M; Steele, VE	1

Trials

2 trial(s) available for oltipraz and acetylcysteine

Article	Year
Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China. Journal of the National Cancer Institute, 1999, Feb-17, Volume: 91, Issue:4 Topics: Acetylcysteine; Aflatoxin B1; Anticarcinogenic Agents; Carcinogens; China; Cytochrome P-450 CYP1A2; Double-Blind Method; Drug Administration Schedule; Feasibility Studies; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Humans; Liver Neoplasms; Pyrazines; Reproducibility of Results; Thiones; Thiophenes; Treatment Outcome	1999
Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001, Volume: 10, Issue:3 Topics: Acetylcysteine; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fatigue; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Pyrazines; Reference Values; Risk Assessment; Smoking; Thiones; Thiophenes	2001

Article

Year

Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in residents of Qidong, People's Republic of China.

Journal of the National Cancer Institute, 1999, Feb-17, Volume: 91, Issue:4

Topics: Acetylcysteine; Aflatoxin B1; Anticarcinogenic Agents; Carcinogens; China; Cytochrome P-450 CYP1A2; Double-Blind Method; Drug Administration Schedule; Feasibility Studies; Gas Chromatography-Mass Spectrometry; Glutathione Transferase; Humans; Liver Neoplasms; Pyrazines; Reproducibility of Results; Thiones; Thiophenes; Treatment Outcome

1999

Phase I/pharmacodynamic study of N-acetylcysteine/oltipraz in smokers: early termination due to excessive toxicity.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2001, Volume: 10, Issue:3

Topics: Acetylcysteine; Adult; Aged; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Fatigue; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Pyrazines; Reference Values; Risk Assessment; Smoking; Thiones; Thiophenes

2001

Other Studies

7 other study(ies) available for oltipraz and acetylcysteine

Article	Year
Natural-Product-Inspired Compounds as Countermeasures against the Liver Carcinogen Aflatoxin B Journal of natural products, 2019, 06-28, Volume: 82, Issue:6 Topics: Aflatoxin B1; Antineoplastic Agents, Phytogenic; Biological Products; Carcinogens; Hepatocytes; Humans; Liver; Molecular Structure; Protective Agents	2019
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology. Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3 Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries	2023
Smokers and urinary genotoxins: implications for selection of cohorts and modulation of endpoints in chemoprevention trials. Journal of cellular biochemistry. Supplement, 1996, Volume: 25 Topics: Acetylcysteine; Adult; Anticarcinogenic Agents; Biomarkers, Tumor; Chemoprevention; China; Clinical Trials, Phase II as Topic; Cohort Studies; DNA Repair; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mutagenicity Tests; Mutagens; Netherlands; Pyrazines; Research Design; Smoking; Thiones; Thiophenes	1996
Modulation of biomarkers by chemopreventive agents in smoke-exposed rats. Cancer research, 2001, Mar-15, Volume: 61, Issue:6 Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; Biomarkers; DNA Adducts; DNA Damage; Eating; Hemoglobins; Inhalation Exposure; Lung; Male; Micronuclei, Chromosome-Defective; Nicotiana; Oxidation-Reduction; Plants, Toxic; Pyrazines; Rats; Rats, Sprague-Dawley; Smoke; Smoking; Thiones; Thiophenes; Tobacco Smoke Pollution; Weight Gain	2001
Formation of DNA adducts in the aorta of smoke-exposed rats, and modulation by chemopreventive agents. Mutation research, 2001, Jul-25, Volume: 494, Issue:1-2 Topics: Acetylcysteine; Animals; Aorta, Thoracic; Arteriosclerosis; Chemoprevention; DNA Adducts; Eating; Male; Pyrazines; Rats; Rats, Sprague-Dawley; Smoking; Thiones; Thiophenes; Weight Gain	2001
Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis, 2007, Volume: 28, Issue:2 Topics: Acetylcysteine; Anticarcinogenic Agents; Antioxidants; Base Sequence; Biological Products; Blotting, Western; Cell Line, Tumor; Curcumin; Cysteine; DNA Modification Methylases; DNA Primers; DNA Repair Enzymes; Dose-Response Relationship, Drug; Fenretinide; Glutathione; Glutathione S-Transferase pi; Humans; Lymphocytes; Prodrugs; Pyrazines; RNA, Messenger; Silymarin; Thiones; Thiophenes; Tumor Suppressor Protein p14ARF; Tumor Suppressor Proteins	2007
Chemoprevention of cigarette smoke-induced alterations of MicroRNA expression in rat lungs. Cancer prevention research (Philadelphia, Pa.), 2010, Volume: 3, Issue:1 Topics: Acetylcysteine; Animals; Anticarcinogenic Agents; beta-Naphthoflavone; Chemoprevention; Cluster Analysis; Enzyme Inhibitors; Gene Expression; Indoles; Isothiocyanates; Lung; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; Principal Component Analysis; Pyrazines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Thiones; Thiophenes; Tobacco Smoke Pollution	2010