oltipraz has been researched along with 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine in 4 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, SG; Lee, JM; Lee, YH; Lee, YS | 1 |
| Baron, P; Bornmann, WG; Polsky, B; Prochaska, HJ | 1 |
| Cho, SH; Choi, JY; Choi, YH; Chon, CY; Han, JY; Jang, JJ; Jang, JW; Kim, SG; Kim, YM; Lee, DH; Lee, MG; Lee, YS; Um, SH; Yu, ES | 1 |
| Kang, SG; Kim, SG; Lee, WH; Lee, YH; Lee, YS | 1 |
1 trial(s) available for oltipraz and 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine
| Article | Year |
|---|---|
Pharmacokinetics of oltipraz and its major metabolite (RM) in patients with liver fibrosis or cirrhosis: relationship with suppression of circulating TGF-beta1.
Topics: Administration, Oral; Adult; Antiviral Agents; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged; Pyrazines; Thiones; Thiophenes; Transforming Growth Factor beta1 | 2010 |
3 other study(ies) available for oltipraz and 7-methyl-6,8-bis(methylthio)pyrrolo(1,2-a)pyrazine
| Article | Year |
|---|---|
Synthesis and biological evaluation of 1,2-dithiol-3-thiones and pyrrolo[1,2-a]pyrazines as novel hypoxia inducible factor-1 (HIF-1) inhibitor.
Topics: Antineoplastic Agents; Glucose Transporter Type 1; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; Pyrazines; Thiones; Thiophenes; Transcriptional Activation; Vascular Endothelial Growth Factor A | 2016 |
Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz.
Topics: Antiviral Agents; Cell Line; HIV Reverse Transcriptase; HIV-1; Humans; Pyrazines; Reverse Transcriptase Inhibitors; Thiones; Thiophenes; Tumor Cells, Cultured; Virus Replication | 1995 |
Hypoxia-inducible factor-1α inhibition by a pyrrolopyrazine metabolite of oltipraz as a consequence of microRNAs 199a-5p and 20a induction.
Topics: Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; HT29 Cells; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin; MicroRNAs; Neoplasm Invasiveness; Neovascularization, Pathologic; Pyrazines; Pyridazines; Pyrroles; Thiones; Thiophenes | 2012 |