olopatadine-hydrochloride and prednisolone-acetate

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal, Humanized; Conjunctivitis; Cyclosporine; Dermatitis, Atopic; Drug Therapy, Combination; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Interleukin-4 Receptor alpha Subunit; Male; Olopatadine Hydrochloride; Prednisolone; Slit Lamp Microscopy

To report the incidence and risk factors of elevated IOP following deep anterior lamellar keratoplasty (DALK).. A retrospective case series.. A retrospective study investigating the 5-year incidence of raised IOP following DALK cases performed from 2004 to 2008 in a tertiary center. Patients with less than 6 months of follow-up were excluded. Elevated IOP was defined as IOP >21 mm Hg.. An episode of elevated IOP occurred in 36.1% of cases (44/122 cases), 11.4% (n = 5) occurring within the first week. The average duration of raised IOP was 48.9 (SD: 65.5) days. Causes included pupil block from air, swollen grafts, and corticosteroid response. Surgical intervention to lower IOP was required in 3 cases (6.8%). In multivariate analyses, the use of Olopatadine 0.1% or cyclosporine eye drops before DALK (OR = 14.51, 95% CI = 1.43-147.23) and use of topical prednisolone acetate 1% compared with dexamethasone 0.1% post DALK (OR = 4.79, 95% CI = 0.73-31.52) were associated with higher rates of elevated IOP post DALK. At 5 years post DALK, 3 of 71 cases (4.48%) developed de novo glaucomatous field defects, and 1 case with pre-existing glaucoma had progression of glaucomatous field defect.. DALK was associated with a significant incidence of transiently elevated IOP postoperatively, but had a low incidence of de novo glaucoma at 5 years in our study. Risk factors for raised IOP post DALK included the use of topical prednisolone acetate 1% compared with dexamethasone 0.1%, and the use of Olopatadine 0.1% or any concentration of cyclosporine eye drops prior to DALK.

Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Corneal Transplantation; Cyclosporine; Dexamethasone; Female; Glaucoma, Open-Angle; Glucocorticoids; Humans; Immunosuppressive Agents; Incidence; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Olopatadine Hydrochloride; Prednisolone; Retrospective Studies; Risk Factors; Tonometry, Ocular