olopatadine-hydrochloride and oxatomide

The antiallergic drugs oxatomide and KW-4679 were assessed to show inhibitory effects on ionic currents and intracellular Ca2+ concentration ([Ca2+]i) increase induced by acetylcholine (ACh) in isolated acini of the guinea pig nasal gland. Both K+ and Cl- currents evoked by ACh were inhibited by addition of oxatomide and KW-4679 at the concentration of 10(-5) M. KW-4679 (10(-5) M) inhibited the increase in [Ca2+]i induced by ACh, whereas no effect of oxatomide (10(-5) M) on Ca2+ responses was observed. These findings suggest that both drugs suppress electrolyte and fluid secretion in the nasal glands by different mechanisms.

Topics: Acetylcholine; Animals; Calcium; Chloride Channels; Dibenzoxepins; Guinea Pigs; Histamine H1 Antagonists; Nasal Mucosa; Olopatadine Hydrochloride; Piperazines; Potassium Channels