olopatadine-hydrochloride and 1-4-naphthoquinone

olopatadine-hydrochloride has been researched along with 1-4-naphthoquinone* in 1 studies

Other Studies

1 other study(ies) available for olopatadine-hydrochloride and 1-4-naphthoquinone

ArticleYear
Antiallergic effects of pigments isolated from green sea urchin (Strongylocentrotus droebachiensis) shells.
    Planta medica, 2013, Volume: 79, Issue:18

    This study was undertaken to evaluate possible antiallergic effects of an extract of pigments from green sea urchin (Strongylocentrotus droebachiensis) shells. Effects were studied on animal models - guinea pig ileum contraction, rabbit eyes allergic conjunctivitis, and rabbit local skin irritation. The extract significantly reduced, in a dose-dependent manner, the histamine-induced contractions of the isolated guinea pig ileum with ID50 =1.2 µg/mL (in equivalents of spinochrome B), had an inhibitory effect on the model of ocular allergic inflammation surpassing the reference drug olopatadine, and did not show any irritating effect in rabbits. The extract predominantly contained polyhydroxy-1,4-naphthoquinone which would be responsible for the pharmacological activity. The active compounds of the extract were evaluated in silico with molecular docking. Molecular docking into H1R receptor structures obtained from molecular dynamic simulations showed that all spinochrome derivatives bind to the receptor active site, but spinochrome monomers fit better to it. The results of the present study suggest possibilities for the development of new agents for treating allergic diseases on the base of pigments from sea urchins shells.

    Topics: Animal Shells; Animals; Anti-Allergic Agents; Conjunctivitis, Allergic; Dibenzoxepins; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Ileum; Male; Molecular Docking Simulation; Naphthoquinones; Olopatadine Hydrochloride; Pigments, Biological; Rabbits; Skin; Strongylocentrotus

2013
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