Page last updated: 2024-09-04

olmesartan and topotecan

olmesartan has been researched along with topotecan in 3 studies

Compound Research Comparison

Studies (olmesartan)	Trials (olmesartan)	Recent Studies (post-2010) (olmesartan)	Studies (topotecan)	Trials (topotecan)	Recent Studies (post-2010) (topotecan)
841	185	554	2,392	626	792

Protein Interaction Comparison

Protein	Taxonomy	topotecan (IC50)
Cytochrome P450 3A4	Homo sapiens (human)	1.5211
DNA topoisomerase 1	Homo sapiens (human)	0.8525
DNA topoisomerase 2-alpha	Homo sapiens (human)	0.605
DNA topoisomerase 2-beta	Homo sapiens (human)	0.605
Hypoxia-inducible factor 1-alpha	Homo sapiens (human)	0.06
Multidrug and toxin extrusion protein 2	Homo sapiens (human)	8.6
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	0.17

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	2 (66.67)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Amano, N; Maeda, K; Moriwaki, T; Nakakariya, M; Ono, M; Sugiyama, Y	1

Reviews

1 review(s) available for olmesartan and topotecan

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010

Other Studies

2 other study(ies) available for olmesartan and topotecan

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:3 Topics: Angiotensin Receptor Antagonists; Animals; beta-Lactams; Biliary Tract; Biological Transport; Cells, Cultured; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Topotecan	2012

Article

Year

Hologram QSAR model for the prediction of human oral bioavailability.

Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007

In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:3

Topics: Angiotensin Receptor Antagonists; Animals; beta-Lactams; Biliary Tract; Biological Transport; Cells, Cultured; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Topotecan

2012