Page last updated: 2024-09-04

olmesartan and pravastatin

olmesartan has been researched along with pravastatin in 15 studies

Compound Research Comparison

Studies
(olmesartan)
Trials
(olmesartan)
Recent Studies (post-2010)
(olmesartan)
Studies
(pravastatin)
Trials
(pravastatin)
Recent Studies (post-2010) (pravastatin)
8411855543,5751,036816

Protein Interaction Comparison

ProteinTaxonomyolmesartan (IC50)pravastatin (IC50)
3-hydroxy-3-methylglutaryl-coenzyme A reductaseHomo sapiens (human)0.1452
Insulin receptor Rattus norvegicus (Norway rat)0.0056
Prostaglandin G/H synthase 2Homo sapiens (human)0.0056
3-hydroxy-3-methylglutaryl-coenzyme A reductase Rattus norvegicus (Norway rat)0.0254
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)3.6

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (53.33)29.6817
2010's7 (46.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Andricopulo, AD; Moda, TL; Montanari, CA1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A1
Amano, N; Maeda, K; Moriwaki, T; Nakakariya, M; Ono, M; Sugiyama, Y1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Chang, NC; Chou, TF; Lee, TM; Lin, MS1
Dong, YF; Kataoka, K; Kim-Mitsuyama, S; Lai, ZF; Matsuba, S; Ogawa, H; Tanaka, T; Tokutomi, Y; Yamamoto, E; Yamashita, T1
Havekes, LM; Jukema, JW; Kleemann, R; Kooistra, T; Princen, HM; van der Hoorn, JW1
Chen, M; Ichiki, T; Imayama, I; Inanaga, K; Miyazaki, R; Ohtsubo, H; Sunagawa, K1
David, S; Fliser, D; Haller, H; Kielstein, JT; Kümpers, P; Lukasz, A1
Ishihara, Y; Kohno, M; Kosaka, H; Mizukawa, M; Noma, T; Obayashi, A; Ohmori, K; Yoshida, J; Yukiiri, K1
Horiuchi, M; Inaba, S; Iwai, M; Kanno, H; Mogi, M; Nakaoka, H; Senba, I; Sone, H1
David, S; Fliser, D; Haller, H; Kielstein, JT; Lorenzen, JM; Neunhöffer, H1
Eldawoody, H; Kimura, N; Nakayama, T; Saito, A; Shimizu, H; Takahashi, A; Tominaga, T1
Akishita, M; Iijima, K; Ito, Y; Ouchi, Y; Son, BK1

Reviews

1 review(s) available for olmesartan and pravastatin

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010

Trials

1 trial(s) available for olmesartan and pravastatin

ArticleYear
Circulating angiopoietin-2 in essential hypertension: relation to atherosclerosis, vascular inflammation, and treatment with olmesartan/pravastatin.
    Journal of hypertension, 2009, Volume: 27, Issue:8

    Topics: Adult; Aged; Angiopoietin-2; Angiotensin II Type 1 Receptor Blockers; Atherosclerosis; C-Reactive Protein; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Imidazoles; Male; Middle Aged; Pravastatin; Prospective Studies; Tetrazoles; Vasculitis

2009

Other Studies

13 other study(ies) available for olmesartan and pravastatin

ArticleYear
Hologram QSAR model for the prediction of human oral bioavailability.
    Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24

    Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2007
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7

    Topics: Glutathione; Pharmacology; Sulfur Radioisotopes

2011
In vivo biliary clearance should be predicted by intrinsic biliary clearance in sandwich-cultured hepatocytes.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:3

    Topics: Angiotensin Receptor Antagonists; Animals; beta-Lactams; Biliary Tract; Biological Transport; Cells, Cultured; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Topotecan

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Additive effects of combined blockade of AT1 receptor and HMG-CoA reductase on left ventricular remodeling in infarcted rats.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelin-1; Gene Expression Regulation; Heart Ventricles; Hemodynamics; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertrophy, Left Ventricular; Imidazoles; Male; Myocardial Infarction; Pravastatin; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Tetrazoles; Ventricular Remodeling

2006
Pravastatin enhances beneficial effects of olmesartan on vascular injury of salt-sensitive hypertensive rats, via pleiotropic effects.
    Arteriosclerosis, thrombosis, and vascular biology, 2007, Volume: 27, Issue:3

    Topics: Animals; Disease Models, Animal; Drug Interactions; Drug Therapy, Combination; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Imidazoles; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Pravastatin; Rats; Rats, Inbred Dahl; Reference Values; Risk Factors; Sensitivity and Specificity; Sodium Chloride, Dietary; Tetrazoles; Vascular Diseases

2007
Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice.
    Journal of hypertension, 2007, Volume: 25, Issue:12

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apolipoprotein E3; Atherosclerosis; Blood Pressure; Collagen; Diet, Atherogenic; Drug Synergism; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Inflammation; Lipids; Macrophages; Mice; Mice, Transgenic; Monocytes; Muscle, Smooth, Vascular; Pravastatin; Recombinant Proteins; Serum Amyloid A Protein; T-Lymphocytes; Tetrazoles

2007
Inhibition of balloon injury-induced neointimal formation by olmesartan and pravastatin in rats with insulin resistance.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2007, Volume: 30, Issue:10

    Topics: Angioplasty, Balloon; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Carotid Artery Diseases; Carotid Artery Injuries; Carotid Artery, Common; Cell Count; Cell Proliferation; Fructose; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Immunohistochemistry; Insulin Resistance; Male; Pravastatin; Rats; Rats, Sprague-Dawley; Stem Cells; Tetrazoles

2007
Effects of combined olmesartan and pravastatin on glucose intolerance and cardiovascular remodeling in a metabolic-syndrome model.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2009, Volume: 32, Issue:7

    Topics: Adiponectin; Adipose Tissue, White; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Blood Pressure; Blotting, Western; Body Weight; Cardiovascular System; Drug Therapy, Combination; Eating; Glucose Intolerance; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Lipids; Male; Metabolic Syndrome; Nitric Oxide Synthase Type III; Oxidation-Reduction; Pravastatin; Rats; Rats, Inbred OLETF; RNA, Messenger; Superoxides; Tetrahydrofolate Dehydrogenase; Tetrazoles

2009
Improvement of glucose intolerance by combination of pravastatin and olmesartan in type II diabetic KK-A(y) mice.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2009, Volume: 32, Issue:8

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antimetabolites; Antioxidants; Blood Glucose; Cyclic N-Oxides; Deoxyglucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glucose Intolerance; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Oxidative Stress; Pravastatin; Spin Labels; Tetrazoles

2009
Angiotensin II receptor blocker and statins lower elevated levels of osteopontin in essential hypertension--results from the EUTOPIA trial.
    Atherosclerosis, 2010, Volume: 209, Issue:1

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Atherosclerosis; Biomarkers; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Imidazoles; Male; Middle Aged; Osteopontin; Pravastatin; Prospective Studies; Randomized Controlled Trials as Topic; Tetrazoles

2010
Effect of olmesartan and pravastatin on experimental cerebral aneurysms in rats.
    Brain research, 2010, Mar-31, Volume: 1322

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cerebral Arteries; Circle of Willis; Corrosion Casting; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelial Cells; Hydralazine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Intracranial Aneurysm; Microscopy, Electron, Scanning; Pravastatin; Rats; Tetrazoles; Treatment Outcome; Vasodilator Agents

2010
Pravastatin and olmesartan synergistically ameliorate renal failure-induced vascular calcification.
    Journal of atherosclerosis and thrombosis, 2014, Volume: 21, Issue:9

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Blood Pressure; Calcinosis; Drug Synergism; Drug Therapy, Combination; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Male; Pravastatin; Rats; Rats, Wistar; Renal Insufficiency; Tetrazoles

2014