oligomycins and cumene-hydroperoxide

In state 4, the cumene hydroperoxide-induced decrease of mitochondrial transmembrane potential is prevented by the free radical scavenger, butylhydroxytoluene. This decrease is accompanied by accumulation of lipid hydroperoxides. Oligomycin suppresses the cumene hydroperoxide-induced uncoupling of mitochondria, but has no significant effect on lipid peroxidation. The transition of mitochondria from state 4 to state 3 by ADP addition leads to the suppression of both lipid peroxidation and mitochondrial uncoupling. This effect on lipid peroxidation is prevented by carboxyatractyloside and oligomycin.

Topics: Adenosine Diphosphate; Animals; Benzene Derivatives; Butylated Hydroxytoluene; Dicyclohexylcarbodiimide; Electrochemistry; Lipid Peroxidation; Membrane Potentials; Mitochondria, Liver; Oligomycins; Onium Compounds; Organophosphorus Compounds; Proton-Translocating ATPases; Rats