oligomycins and 3--5--diiodothyronine

oligomycins has been researched along with 3--5--diiodothyronine* in 1 studies

Other Studies

1 other study(ies) available for oligomycins and 3--5--diiodothyronine

Article	Year
Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats affects bioenergetic parameters in rat skeletal muscle mitochondria. FEBS letters, 2007, Dec-22, Volume: 581, Issue:30 We investigated the mechanism by which 3,5-diiodo-l-thyronine (T2) affects skeletal muscle mitochondrial bioenergetic parameters following its acute administration to hypothyroid rats. One hour after injection, T2 increased both coupled and uncoupled respiration rates by +27% and +42%, respectively. Top-down elasticity analysis revealed that these effects were the result of increases in the substrate oxidation and mitochondrial uncoupling. Discriminating between proton-leak and redox-slip processes, we identified an increased mitochondrial proton conductance as the "pathway" underlying the effect of T2 on mitochondrial uncoupling. As a whole, these results may provide a mechanism by which T2 rapidly affects energy metabolism in hypothyroid rats. Topics: Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Respiration; Diiodothyronines; Energy Metabolism; Hypothyroidism; Kinetics; Male; Malonates; Membrane Potential, Mitochondrial; Mitochondria, Muscle; Muscle, Skeletal; Oligomycins; Oxidation-Reduction; Phosphorylation; Protons; Rats; Rats, Wistar	2007

Article

Year

Acute administration of 3,5-diiodo-L-thyronine to hypothyroid rats affects bioenergetic parameters in rat skeletal muscle mitochondria.

FEBS letters, 2007, Dec-22, Volume: 581, Issue:30

We investigated the mechanism by which 3,5-diiodo-l-thyronine (T2) affects skeletal muscle mitochondrial bioenergetic parameters following its acute administration to hypothyroid rats. One hour after injection, T2 increased both coupled and uncoupled respiration rates by +27% and +42%, respectively. Top-down elasticity analysis revealed that these effects were the result of increases in the substrate oxidation and mitochondrial uncoupling. Discriminating between proton-leak and redox-slip processes, we identified an increased mitochondrial proton conductance as the "pathway" underlying the effect of T2 on mitochondrial uncoupling. As a whole, these results may provide a mechanism by which T2 rapidly affects energy metabolism in hypothyroid rats.

Topics: Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Respiration; Diiodothyronines; Energy Metabolism; Hypothyroidism; Kinetics; Male; Malonates; Membrane Potential, Mitochondrial; Mitochondria, Muscle; Muscle, Skeletal; Oligomycins; Oxidation-Reduction; Phosphorylation; Protons; Rats; Rats, Wistar

2007