oleoyl-coenzyme-a and 1-oleoyl-2-acetylglycerol

Oleoyl coenzyme A and other acyl-CoA derivatives inhibited ADP or thrombin-induced aggregation of platelets. Arachidonic acid-induced aggregation was also inhibited, but not the slower aggregation caused by 1-oleoyl-2-acetylglycerol or tetradecanoyl-phorbol-13-acetate. Coenzyme A and free fatty acids had little or no effect, and transfer of labeled oleate from oleoyl Co-A to other lipid classes was not detected. Because acyl Co-A compounds have recently been shown to modulate protein kinase C activity, acyl Co-A may provide a useful tool for investigating activation sequences in platelets and other membranes.

Topics: Acyl Coenzyme A; Adenosine Diphosphate; Arachidonic Acid; Arachidonic Acids; Coenzyme A; Diglycerides; Dose-Response Relationship, Drug; Humans; Kinetics; Platelet Aggregation; Platelet Aggregation Inhibitors; Tetradecanoylphorbol Acetate; Thrombin