oleanolic acid has been researched along with saikosaponin d in 399 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (9.52) | 18.7374 |
| 1990's | 48 (12.03) | 18.2507 |
| 2000's | 70 (17.54) | 29.6817 |
| 2010's | 176 (44.11) | 24.3611 |
| 2020's | 67 (16.79) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, FK; Guo, YZ; Kano, Y; Meng, XS | 1 |
| Du, X; Liu, M | 1 |
| Abe, H; Ushio, Y | 4 |
| Abe, H; Oda, Y; Ushio, Y | 1 |
| Chuang, CH; Lin, CC; Liu, SY; Yen, MH | 1 |
| Du, X; Jiang, C; Liu, M | 1 |
| Chang, WC; Hsu, FL | 1 |
| Hattori, T; Ito, M; Suzuki, Y | 1 |
| Hayashi, T; Horii, I; Nakayama, Y; Nishiyama, T; Ozawa, T | 1 |
| Kawakita, T; Kumazawa, Y; Nomoto, K; Takimoto, H | 1 |
| Kanazawa, H; Matsushima, Y; Nagata, Y; Takai, N; Tomoda, M | 1 |
| Amagaya, S; Nose, M; Ogihara, Y | 2 |
| Dong, YY; Luo, SQ | 1 |
| Jia, Q; Zhang, RY | 1 |
| Kawakita, T; Kumazawa, Y; Nishimura, C; Nomoto, K; Takimoto, H | 1 |
| Abe, H; Arichi, S; Konishi, H; Odashima, S; Orita, M | 2 |
| Arichi, S; Hashimoto, M; Inada, K; Kimura, Y; Ohminami, H; Okuda, H | 1 |
| Zhang, J | 1 |
| Zhang, WX | 1 |
| Jyumonji, N; Kohno, H; Odashima, S; Yamaguchi, N; Yamazaki, M | 1 |
| Jin, RL; Kuang, Y; Shi, L | 1 |
| Hiai, S; Yokoyama, H | 2 |
| Amagaya, S; Iwama, H; Ogihara, Y | 1 |
| Motomura, H; Sakuma, S | 1 |
| Fujiwara, K; Ogihara, Y | 1 |
| Abe, H; Kohno, H; Odashima, S; Tawara, M; Yamaguchi, N | 1 |
| Ohuchi, K; Ozeki, T; Tsurufuji, S; Watanabe, M | 1 |
| Ito, K; Kimata, H; Matsufuji, N; Morita, T; Sumida, N; Tanaka, O; Yata, N | 1 |
| Amagaya, S; Ogihara, Y; Shimizu, K | 2 |
| Liu, AJ; Wang, BZ; Wang, GZ | 1 |
| Li, XZ | 1 |
| Chang, XL | 1 |
| Ma, JL; Wang, GZ; Zhou, ZC | 1 |
| Arichi, S; Hayashi, T; Kimura, Y; Ohminami, H; Okuda, H; Tani, T | 1 |
| Hiraoka, E; Hirotani, Y; Kishi, H; Maeda, Y; Oishi, M; Yamaji, A; Yoneda, K | 1 |
| Han, DW; Li, CM; Ma, XH; Yin, L; Zhao, MQ; Zhao, YC | 1 |
| Hiai, S; Oura, H; Yokoyama, H | 2 |
| Abe, H; Arichi, S; Odashima, S; Sakaguchi, M | 1 |
| Abe, H; Arichi, S; Sakaguchi, M | 1 |
| Abe, H; Arichi, S; Odashima, S; Sakaguchi, M; Yamada, M | 1 |
| Abe, H; Anno, M; Arichi, S; Sakaguchi, M | 1 |
| Hiai, S; Nagasawa, T; Oura, H; Yokoyama, H | 1 |
| Abe, H; Arichi, S; Komiya, H; Konishi, H | 1 |
| Hata, T; Itoh, E; Kita, T; Yoneda, R | 1 |
| Lin, CC; Liu, SY; Son, LM; Wang, JY; Wu, WK; Yen, MH | 1 |
| Hattori, T; Isobe, K; Kato, M; Nakashima, I; Pu, MY; Yanagita, N | 1 |
| Li, Q; Murakamio, T; Okita, K; Takahashi, M | 1 |
| Giner, RM; Hostettmann, K; Just, MJ; Mañez, S; Recio, MC; Rios, JL | 1 |
| Kimura, Y; Murakami, T; Okita, K; Qian, L; Takahashi, M | 1 |
| Hattori, T; Isobe, K; Iwamoto, T; Kato, M; Lwin, T; Nagase, F; Nakashima, I; Pu, MY; Yanagita, N; Zhang, YH | 1 |
| Chang, TY; Hung, CR; Wu, TS | 1 |
| Chen, XK; Jiang, TY; Wang, B; Zhang, RY; Zhang, ZL | 1 |
| Maeda, T; Miyase, T; Ueno, A; Yamamoto, A | 1 |
| Ishihara, K; Ito, K; Kosuge, E; Kuriyama, M; Nakamura, T | 1 |
| Ashida, K; Hasegawa, C; Minami, M; Ohe, C; Sugino, M; Yomo, T | 1 |
| Dobashi, I; Horiba, N; Sakai, K; Sakai, Y; Suda, T; Tozawa, F | 1 |
| Fujikawa-Yamamoto, K; Odashima, S; Tanino, M; Teraoka, K; Yamagishi, H; Zong, Z | 1 |
| Fukuda, K; Kojiro, M; Ohtsuka, M; Yano, H | 1 |
| Kawachi, H; Li, P; Morioka, T; Oite, T; Orikasa, M; Shi, ZS; Shimizu, F | 1 |
| Matsushima, Y; Miyase, T | 1 |
| Horikoshi, C; Kusano, G; Melek, FR; Miyasaka, S; Miyase, T; Yabe, S | 1 |
| Akao, T; Hattori, M; Kida, H; Meselhy, MR | 2 |
| Kashimoto, T; Kudo, K; Tachikawa, E; Takahashi, E | 1 |
| Ebizuka, Y; Jung, DW; Shibuya, M; Shimomura, K; Sung, CK; Yoshimatsu, K | 1 |
| Abad Martínez, MJ; Bermejo Benito, P; Díaz Lanza, AM; Fernández Matellano, L; Sánchez Contreras, S; Sanz Gómez, A; Silván Sen, AM | 1 |
| Hiai, S; Nagasawa, T; Zhang, ZQ; Zhou, QL | 1 |
| Jiang, Y; Jing, H; Luo, S | 1 |
| Fujikawa-Yamamoto, K; Guan, X; Li, A; Murakami, M; Odashima, S; Ota, T; Tanino, M; Yamaguchi, N; Zong, Z | 1 |
| Jung, DW; Sung, CK | 1 |
| Cai, S; Tan, L; Tu, G; Wang, B; Zhang, R; Zhao, Y | 1 |
| Kodama, Y; Kubo, M; Kyo, R; Nakahata, N; Nakai, Y; Ohizumi, Y | 1 |
| Kang, EM; Kim, N; Park, IS | 1 |
| Cheng, JS; Hsu, MJ; Huang, HC | 1 |
| Liang, H; Liu, QX; Wang, B; Yang, WX; Yu, Y; Zhao, YY | 1 |
| Hsu, HY; Wu, WS | 1 |
| Cui, R; Liang, Y | 1 |
| Kim, N; Park, IS | 1 |
| Nomura, T; Wang, Y; Xing, S; Yano, Y | 1 |
| Bu, S; Sun, J; Xu, J | 2 |
| Li, XD; Liang, H; Wang, H; Yang, WX; Yu, Y; Zhang, WZ; Zhao, YY | 1 |
| Aoyagi, H; Kobayashi, Y; Kusakari, K; Tanaka, H; Yamada, K; Yokoyama, M | 1 |
| Abad, MJ; Bermejo, P; Carrasco, L; De Santos, J; Díaz, AM; Fernández, L; Irurzun, A; Sanchez, S; Villaescusa, L | 1 |
| Chen, IL; Horng, LY; Tsai, YJ; Wu, RT | 1 |
| Huang, J; Liang, H; Qiu, H; Zhang, R; Zhao, Y | 1 |
| Bai, Y; Liang, H; Tu, G; Zhang, R; Zhao, Y | 1 |
| Dong, ZY; Liu, BH; Wang, H; Yang, WX; Yu, Y; Zhang, WZ | 1 |
| Koh, D; Lim, Y; Park, J; Park, KH | 1 |
| Chen, YH; Ge, FH; Li, Q; Li, XF; Li, Y; Lin, YC; Ma, GJ; Xie, JM | 1 |
| Wen-Sheng, W | 1 |
| Fujii, H; Fujioka, T; Mihashi, K; Nagao, T; Okabe, H; Yoshida, K | 1 |
| Yu, J | 1 |
| Chang, NW; Chen, JC; Chen, KC; Chung, JG | 1 |
| Chiang, LC; Lin, CC; Liu, LT; Ng, LT; Shieh, DE | 1 |
| Li, P; Li, PH; Zhang, ZY | 1 |
| Shimokawa, S; Shoyama, Y; Tanaka, H; Zhu, SH | 1 |
| Hsu, YL; Kuo, PL; Lin, CC | 1 |
| Bao, Y; Li, C; Nan, F; Shen, H | 1 |
| Chiang, LC; Hsu, YL; Kuo, PL; Lin, CC | 1 |
| Lee, CC; Liu, YC; Shyu, KG; Tsai, SC; Wang, BW | 1 |
| Chen, BT; Huang, YS; Xie, W | 1 |
| Ding, WX; Li, P; Maitani, Y; Nagai, T; Qi, XR | 1 |
| Lin, X; Xue, L; Zhang, H; Zhu, C | 1 |
| Gong, Y; Li, P; Li, Y; Shimizu, F; Wang, B; Zu, N | 1 |
| Bi, KS; Chen, XH; Gao, QT; Li, XQ | 1 |
| Chen, YW; Ding, WX; Li, KM; Li, P; Qi, XR | 1 |
| Leung, CY; Li, M; Liu, L; Wong, RN; Zeng, YY; Zhou, H | 1 |
| Shimokawa, S; Shoyama, Y; Tanaka, H; Zhu, S | 1 |
| He, SX; Luo, JY; Wang, YL | 1 |
| Bao, Y; Hou, GN; Tan, HX; Xie, W; Yu, LJ | 1 |
| Hattori, T; Kase, Y; Maruyama, H; Nakai, Y; Nishimura, H; Sakakibara, I; Takeda, S | 1 |
| Wang, CY; Xiao, R; Yuan, ZF; Zhang, LT; Zhang, ZF | 1 |
| Bao, Y; Chen, YY; Xie, W; Yu, LJ | 1 |
| Morinaga, O; Shoyama, Y; Tanaka, H; Zhu, S | 1 |
| Cheng, PW; Chiang, LC; Lin, CC; Ng, LT | 1 |
| Bao, Y; Li, CZ; Xie, W; Yu, LJ | 1 |
| Chen, T; Dong, Y; Sun, Y; Xu, Q; Zhang, L | 1 |
| Dong, L; Fu, H; He, SX; Luo, JY; Wang, YL; Xu, JL; Zhao, G | 1 |
| Chiang, ST; Hsiao, SS; Jong, TT; Lee, MR; Liau, BC | 1 |
| Ahn, J; Cho, JH; Hwang, B; Kim, YS | 1 |
| Cheng, YA; Dang, SS; Li, ZF; Liu, ZG; Song, P; Wang, BF | 1 |
| Huang, CG; Tang, YH; Zhang, YY; Zhu, HY | 1 |
| Chang, JS; Chen, MC; Chiang, LC; Lin, CC; Liu, HW; Wang, KC | 1 |
| Dong, X; Fu, GX; Zu, N | 1 |
| Choy, P; Gong, Y; Li, N; Li, P; Zu, N | 1 |
| Choy, P; Fan, J; Gong, Y; Li, N; Li, P; Li, X; Shen, H; Siow, Y; Wang, T | 1 |
| Cheng, WJ; Cheng, XL; Chu, KD; Liu, JZ; Liu, QB; Pan, XD; Shi, YL; Tan, YH; Yu, KY; Zhang, MJ; Zheng, S | 1 |
| Bao, Y; Li, CZ; Xie, W; Zhou, Y | 1 |
| Li, YJ; Liu, J; Pei, GJ; Wang, R; Wang, YH; Yang, ZX | 1 |
| Chen, SM; Sato, N; Satoh, N; Ueda, S; Yoshida, M | 1 |
| Hao, JP; Li, YY; Qin, XM; Wang, YQ; Yue, JY | 1 |
| Chao, JC; Chu, CC; Lin, YH; Tsai, YH; Wu, SJ | 1 |
| Hattori, T; Kase, Y; Nishimura, H; Takeda, S | 1 |
| Chen, YW; Guo, JZ; He, Y; Hu, ZF; Li, KM; Li, P; Pan, L; Xiao, C; Xiong, JP | 1 |
| Cai, X; Hu, ZH; Ni, XL; Tan, LL | 1 |
| Huang, HQ; Lin, M; Shen, YH; Yan, SK; Zhang, WD; Zhang, X | 1 |
| Bao, Y; Lin, J; Xie, W; Zhang, ZW; Zhou, Y | 1 |
| Kim, J; Yoon, KD | 1 |
| Liu, HP; Tian, RT; Xie, PS | 1 |
| Huang, HQ; Su, J; Xu, ZX; Yan, SK; Zhang, WD; Zhang, X | 1 |
| Cheung, SS; Li, T; Liu, L; Wong, VK; Zhou, H | 1 |
| Cai, TT; Sun, Y; Xu, Q; Zhou, XB | 1 |
| Li, Y; Ren, JL; Wang, P; Yin, SY; Yuan, DY | 1 |
| Cheng, YA; Dang, SS; Wang, BF | 1 |
| Li, B; Li, Y; Ren, J; Tang, J; Wang, P; Zhang, D | 1 |
| Chang, CC; Chao, JC; Tam, KW; Tsai, YH; Wu, SJ | 1 |
| Bi, J; Guo, Z; Liu, Z; Sun, Y; Wang, J; Wang, Y; Wei, L | 1 |
| An, F; Tian, JM; Wang, CY; Zhang, DS; Zhang, WM | 1 |
| Jin, YY; Li, X; Zhang, Y | 1 |
| Feng, C; Huang, W; Qiao, S; Wang, Y; Zhang, W; Zhang, Y | 1 |
| Huang, ZJ; Lu, KQ; Tian, GR; Xia, DG; Zheng, JX | 1 |
| Eom, HY; Han, SB; Kim, MK; Kim, U; Lee, J; Min, JW; Park, SY; Suh, JH; Yeom, H; Youm, JR | 1 |
| Gotoh, T; Hokari, M; Hori, K; Sugiyama, T; Takahashi, S | 1 |
| Chen, L; Hou, J; Li, W; Liu, Z; Sun, Y; Wang, Z; Zheng, Y | 1 |
| Chen, JX; Fan, CL; Guo, PR; Luo, HT; Tang, YZ; Yang, YY | 1 |
| Lin, R; Tong, L; Wan, M; Wang, G; Wang, Z; Ye, Z; Zhou, D | 1 |
| Huang, W; Sun, R | 2 |
| Chu, Q; Jin, Y; Sui, C; Wei, J; Yang, C; Zheng, T | 1 |
| Hong, SH; Kim, BM | 1 |
| Fan, LY; Pan, HF; Wu, GC; Wu, H | 1 |
| Gao, LB; He, F; Lin, Y; Shi, F; Sun, H; Wang, Q; Wang, X; Yang, L; Zheng, XL; Zhong, YJ | 1 |
| Huang, CG; Li, ZX; Ma, CH; Sun, ZL; Tang, YH; Wang, GY; Ye, G; Zhu, HY | 1 |
| Feng, WS; Li, XK; Wang, QS; Xiao, GS; Yang, Y | 1 |
| Ben Jannet, H; Duchamp, O; Harzallah-Skhiri, F; Jabrane, A; Lacaille-Dubois, MA; Mirjolet, JF; Miyamoto, T; Tanaka, C | 1 |
| Hong, SP; Kwon, HJ; Lee, JH; Lee, SI; Lee, YM; Park, YD; Sim, HJ | 1 |
| He, YF; Li, W; Li, XH; Liang, J; Liu, WC; Wang, Z; Zhao, LC; Zheng, YN | 1 |
| Han, NR; Jeong, HJ; Kim, HM | 1 |
| Chao, Z; Ma, LL; Tan, MM | 1 |
| Gozu, Y; Inomata, S; Katagiri, C; Kusakari, K; Sugimoto, Y; Yokoyama, M | 1 |
| Liu, GQ; Song, R; Tian, JX; Tian, Y; Xu, L; Zhang, ZJ | 1 |
| Kinjo, J; Nakahara, Y; Nohara, T; Okawa, M | 1 |
| Chen, H; Chen, S; Gao, Z; Jin, Y; Li, Y; Sui, C; Wei, J; Xie, C; Xu, J; Xu, Y; Yang, C; Zhang, J; Zhang, Z | 1 |
| Chen, Y; Jia, X; Tan, X; Wang, J; Yuan, L; Zhou, L | 1 |
| Eom, HY; Han, SB; Kim, J; Kim, U; Lee, J; Lee, MY; Suh, JH; Yang, DH | 1 |
| He, SX; Liu, EQ; Lu, XL; Ren, MD; Wang, YL; Zhang, YX | 1 |
| Huang, W; Huang, Y; Lv, L; Sun, R; Wang, R | 1 |
| Liu, Y; Su, B; Wang, X | 1 |
| Li, MY; Pu, R; Wang, LT; Yuan, JK; Zhang, GP; Zhu, BH | 1 |
| Chen, YY; Liu, GW; Xue, DY | 1 |
| Jiang, HF; Sun, YS; Wang, JH; Zhang, SH; Zhu, YX | 1 |
| Choi, YH; Dai, Y; Hu, J; Li, Z; Liu, NQ; Liu, X; Qin, X; Verpoorte, R | 1 |
| Hao, Y; Piao, X | 1 |
| Chen, JX; Liao, M; Lu, CN; Yan, R; Yuan, ZG; Zhang, XL; Zhao, YQ | 1 |
| Dai, X; Qiao, Y; Shi, X; Wang, Y | 1 |
| Cho, HY; Chung, EY; Jang, CG; Kim, HS; Kim, KJ; Yang, CH; Yoon, SS; Yun, J | 1 |
| Chen, Y; Tan, X; Wang, J; Xin, R | 1 |
| Bao, Y; Hu, SJ; Li, HM; Xie, W; Xing, JL; Yu, YH | 1 |
| Li, G; Liu, G; Song, R; Tian, Y; Xu, L; Zhang, Z | 1 |
| Cheng, Y; Dang, S; Jia, X; Li, M; Li, S; Li, Y; Zhang, X | 1 |
| Jiang, H; Li, J; Xu, Y; Zhang, Q; Zhang, YP | 1 |
| Deng, AJ; Liu, Y; Qin, HL; Wang, WJ; Wu, LQ; Yu, JQ; Zhang, ZH | 1 |
| Dai, X; Ding, H; Qiao, Y; Shi, X; Yin, Q | 1 |
| Chang, Q; Guo, Z; Li, ZY; Liao, YH; Liu, XM; Liu, YM; Pan, RL | 1 |
| Chiou, CY; Chiou, SJ; Lin, TY | 1 |
| Chan, PL; Lam, KY; Law, BY; Law, CK; Li, T; Liu, L; Ma, ED; Michelangeli, F; Wong, VK; Yip, NC; Zhang, MM | 1 |
| Burczynski, FJ; Gong, Y; Kong, W; Wang, Q; Wang, X | 1 |
| Chen, L; Chen, W; Kong, D; Wang, A; Zhang, F; Zheng, S; Zhu, X | 1 |
| Guan, YB; Jia, YY; Tian, XZ; Tian, YD | 1 |
| Chen, CH; Chen, MF; Huang, CC; Liu, PS; Shiu, LY | 1 |
| Ann, SH; Cho, HY; Chung, EY; Kim, HS; Kim, HY; Koo, JS; Seo, JW; Yang, CH; Yoon, SS; Yun, J | 1 |
| Bai, MH; Cheng, YA; Dai, ZJ; Lin, S; Ma, HB; Ma, XL; Min, WL; Song, LQ; Wang, BF; Wang, XJ; Wang, YL; Zan, Y | 1 |
| Liu, J; Sui, C; Sun, J; Tao, YW; Wei, JH; Xu, JS; Xu, YH; Yang, X; Zhang, Y | 1 |
| Chatterjee, N; Das, S; Kumar, D; Mallick, S; Pal, BC; Saha, KD | 1 |
| Bai, MH; Cheng, YA; Guan, HT; Kang, HF; Lin, S; Min, WL; Song, LQ; Wang, BF; Wang, XJ; Wang, ZW; Zan, Y | 1 |
| Chang, J; Kim, BM; Lee, TH | 1 |
| Guo, Z; Jiang, YM; Li, ZY; Liu, XM; Liu, YM; Pan, RL; Shen, SN | 1 |
| Chen, X; Chen, Z; Mao, S; Yu, T; Zhao, R | 1 |
| Cao, L; Gao, H; Qu, S; Yang, J; Yao, M; Zhang, L | 1 |
| Chen, X; Mao, S; Wang, Y; Yu, T; Zhao, R | 1 |
| Chen, H; Liang, Z; Oh, K; Wang, Y; Yi, T; Zhao, Z | 1 |
| Bai, MH; Lin, S; Ma, HB; Min, WL; Song, LQ; Wang, BF; Wang, M; Wang, XJ; Yang, P | 1 |
| Cheng, H; Cheng, L; Song, S; Wang, L; Xu, D; Yin, Q; Zhang, M; Zhou, X | 1 |
| Cao, RF; Chen, JW; Cong, X; Cui, K; Gao, SS; Guo, XT; Jiang, ZL; Tian, WR; Zhang, BZ; Zhao, Y | 1 |
| Chen, J; He, S; Hou, H; Lu, G; Lu, X; Wang, Z; Zhao, Z; Zhu, Z | 1 |
| Chen, H; Cui, BS; Li, S; Li, Y; Qiao, YQ; Tang, L; Yuan, Y | 1 |
| Fang, Z; Gonzalez, FJ; Guo, B; Jiang, C; Kim, JH; Krausz, KW; Liu, A; Sun, L; Tanaka, N; Yang, J | 1 |
| Jiang, C; Ling, F; Liu, G; Tu, X; Wang, G; Zhang, Q; Zhu, S | 1 |
| Li, JP; Liu, RY | 1 |
| Gao, X; Qiao, M; Sun, P; Wei, S; Xue, L; Zhang, H | 1 |
| Cui, BS; Hou, Q; Li, S; Qiao, YQ; Tang, L; Yuan, SP; Yuan, Y | 1 |
| Cao, C; Ding, H; Liu, Y | 1 |
| Chang, SP; Chung, CY; Hsu, WC; Hung, TC; Li, CF; Lin, CC; Lin, LT; Richardson, CD; Russell, RS; Shields, J; Tyrrell, DL; Yen, MH | 1 |
| Bae, EY; Choi, HJ; Jang, MJ; Kim, YS; Lee, JH; Lee, SW; Oh, HM; Oh, TS | 1 |
| Li, D; Li, L; Ma, H; Peng, Y; Song, C; Song, S; Wang, F; Wu, C; Wu, Y; Yang, J | 1 |
| Chen, Q; He, W; Liu, W; Song, H; Wang, H; Zhou, C | 1 |
| Jeon, SY; Kim, MR; Kim, SO; Park, JY; Yang, CH | 1 |
| Du, GH; Li, ZY; Qin, XM; Sun, HM; Xing, J | 1 |
| Chen, XF; Li, ZF; Meng, J; Song, JH; Yang, WY; Yang, XW; Zhang, Y | 1 |
| He, MZ; Hu, PY; Li, DX; Luo, XJ; Rao, XY; Wang, YR; Wang, YS; Zhang, GS | 1 |
| Dai, Z; Dang, C; Guan, H; Hui, W; Kang, H; Lin, S; Liu, X; Ma, X; Wang, X | 1 |
| Dai, Z; Liu, F; Quan, W; Shi, J; Wang, H; Wu, B; Wu, Q; Xu, T; Zhang, X; Zhang, Y | 1 |
| Kang, MS; Kang, S; Kim, J; Oh, MS; Pak, CJ; Pak, YK; Park, WH; Piao, Y | 1 |
| Huang, XX; Li, DQ; Li, LZ; Liu, LY; Liu, QB; Song, SJ; Wu, CF; Wu, J; Wu, YY; Yang, JY | 1 |
| Murayama, C; Nakamura, M; Norimoto, H; Watanabe, S | 1 |
| Cao, Y; Fu, Y; Hu, X; Zhang, N; Zhang, Z | 1 |
| Chen, J; Chen, W; Duan, M; Li, B; Li, Q; Liao, M; Ling, F; Liu, Y; Lu, C; Qi, W; Xiao, K; Zeng, Z; Zhao, Y | 1 |
| Chen, L; Jin, H; Lu, Y; Shao, J; Wu, L; Zhang, F; Zheng, S | 1 |
| Hu, SC; Lee, CW; Lee, IT; Lin, CC; Yen, FL; Yen, MH | 1 |
| Gao, X; Li, P; Liu, S; Tan, Z; Wang, S; Zeng, Y | 1 |
| Cheng, J; Qu, B; Qu, H; Sai, J; Shan, W; Wang, Q; Zhang, Y; Zhao, Y | 1 |
| Chen, YC; Liang, GW; Niu, QX; Wang, HM; Ye, DY | 1 |
| He, D; Liu, P; Peng, K; Qu, P; Wang, H; Wang, L; Wang, X; Xu, L | 1 |
| Lin, X; Liu, G; Shi, Y; Wang, F; Wang, Q; Wu, S; Zhi, J | 1 |
| Cai, X; Chao, Z; Cui, Q; Li, X; Shoyama, Y; Tanaka, H; Tian, E; Wu, Y; Zeng, W | 1 |
| Chu, Y; Guan, X; Li, S; Li, W; Liu, C; Ma, X; Sun, H; Wang, X; Yan, K; Yan, X; Zhou, S | 1 |
| Qiu, H; Song, R; Tian, Y; Wang, M; Yu, P; Zhang, Z | 1 |
| Carai, MAM; Colombo, G; Corelli, F; Gessa, GL; Lorrai, I; Maccioni, P; Morazzoni, P; Mugnaini, C; Riva, A | 1 |
| Chen, ZD; Ye, RP | 1 |
| Cai, C; Dang, Q; Jiang, YD; Qi, H; Wu, P; Zhang, HJ; Zheng, SB; Zhong, D | 1 |
| Bao, Y; Chang, X; Li, T; Ma, Y; Meng, X; Wang, S; Yang, G | 1 |
| Bi, YF; Ding, L; Gao, W; Ye, M; Zhu, WW | 1 |
| Fu, Y; Liu, W; Shi, M; Wang, J; Wei, Z; Yang, Z | 1 |
| Chen, CH; Chen, MF; Hsieh, WC; Huang, CC; Huang, SJ; Lin, KI; Liu, CW; Liu, PS; Shiu, LY | 1 |
| Wang, YJ; Xiang, FJ; Zhao, RZ; Zhao, Y | 1 |
| Jiang, H; Li, J; Xu, Q | 1 |
| Chen, KT; Hu, YX; Ma, GX; Ma, ZX; Sun, W; Xu, XD; Yang, JS; Yu, SC; Zhang, W; Zhu, NL; Zhu, YD | 1 |
| Liu, Y; Ma, Y; Yang, R; Yuan, B; Zhang, X; Zhou, S | 1 |
| Capra, A; Carai, MA; Castelli, MP; Colombo, G; Gessa, GL; Lorrai, I; Maccioni, P; Morazzoni, P; Riva, A | 1 |
| Fan, S; Huang, W; Yang, X; Zheng, X | 1 |
| Chen, CH; Chen, MF; Hsieh, WC; Huang, CH; Huang, CY; Huang, SJ; Liu, LF; Shiu, LY; Wang, HK | 1 |
| Hayakawa, Y; Ma, H; Saiki, I; Yokoyama, S | 1 |
| Cen, S; Fang, W; Guo, BL; Yang, YJ | 1 |
| Li, S; Peng, S; Qiao, Y; Shen, C; Wang, S; Wu, Q; Yang, W; Yu, Y; Zhang, M; Zhang, Q; Zhang, Y | 1 |
| Huang, Y; Li, X; Liu, R; Lu, J; Luan, Y; Lv, L; Sun, R | 1 |
| Gai, X; Guan, X; Li, C; Wang, M; Wang, P; Xue, H | 1 |
| Cai, T; Li, Y; Lv, S; Zhang, W; Zhu, W | 1 |
| Chen, JJ; Chen, XL; Geng, CA; Huang, XY; Ma, YB; Sun, CL; Yang, TH; Yin, XJ; Zhang, XM; Zheng, XH | 1 |
| Cho, S; Khan, A; Kim, YJ; Lee, S; Pan, JH; Park, YH | 1 |
| Chen, R; Huang, C; Li, B; Li, J; Liu, Y; Ma, T; Meng, X; Shen, C; Wu, M; Xu, Q | 1 |
| Liang, ZS; Liu, SL; Liu, ZL; Xia, PG; Zhang, Y; Zhou, ZY | 1 |
| Fang, F; Li, HW; Li, HY; Li, M; Ma, SP; Qin, TT; Qu, R; Ye, LY; Zeng, MJ; Zhao, YH | 1 |
| Huang, CZ; Jiang, J; Li, D; Li, S; Li, X; Ouyang, Q; Peng, S; Qiao, Y; Wang, S; Wang, X; Zhang, Q; Zhang, Y | 1 |
| Chen, SJ; Chen, XQ; Dong, SQ; Li, CD; Li, CF; Liang, WN; Wang, M; Wang, SS; Yi, LT | 1 |
| Bi, Y; Ding, L; Gao, W; Ye, M; Zhu, W | 1 |
| Du, ZA; Hu, ZS; Sun, MN | 1 |
| Liu, J; Qi, G; Yang, L | 1 |
| Feng, LJ; Gai, XD; Li, C; Wang, ML; Wang, P; Xue, HG | 1 |
| Chen, XL; Dai, YJ; Deng, XY; Tang, HY; Xie, L | 1 |
| Cho, YW; Jeong, JS; Kang, HE; Kwon, MH; Ryu, J | 1 |
| Liting, G; Lixing, X; Rong, Q; Ruyi, Z; Shiping, M; Zhouye, J | 1 |
| Cao, J; Che, D; Dong, X; He, L; Liu, R; Ma, P; Wang, J; Wang, N; Zhang, T; Zhao, T | 1 |
| Li, Y; Que, R; Ren, J; Shen, Y; Tao, Z; Zhu, X | 1 |
| Huang, LQ; Jiao, Q; Li, Y; Liu, AP; Yang, G; Zhang, TT; Zheng, YG | 1 |
| Chen, PH; Chen, YC; Liang, GW; Niu, QX; Pan, XY; Wang, HM; Wang, Y | 1 |
| Cao, Y; Han, RC; Li, XY; Liu, YM; Peng, DY; Yu, NJ; Zhang, W; Zhou, A; Zhu, YJ | 1 |
| Li, X; Pan, R; Song, M; Sun, X; Wang, Q; Xu, Y | 1 |
| Chen, Y; Li, Y; Lin, L; Que, R; Shen, Y; Yan, N | 1 |
| Chen, RJ; Cheng, BH; Gong, YQ; Guo, XY; Lin, MX; Ying, BY | 1 |
| Chen, M; Fu, L; Gu, J; Liu, D; Lv, J; Mei, C; Shi, W; Song, S; Sun, K; Xu, D; Xue, C; Yang, B; Zhou, W | 1 |
| Li, XQ; Rahman, K; Song, YN; Wang, SJ; Zhang, H; Zhu, JY | 1 |
| Pang, Y; Wang, J; Wang, W | 1 |
| Chen, X; Duan, H; Huang, M; Li, G; Liu, Y; Xu, Y; Zhu, S | 1 |
| Kim, BM | 1 |
| Li, WD; Lin, RC; Liu, Y; Ma, YS; Yuan, BC; Zhou, S; Zhu, LF | 1 |
| Chen, X; Liu, C; Wu, J; Ying, M; Zhao, P; Zhao, R; Zhou, N | 1 |
| Fang, Y; Hou, T; Li, G; Liang, X; Liu, Y; Piao, HL; Qi, H; Si, W; Wang, A; Wang, J; Xu, F; Zhang, X; Zhou, H | 1 |
| Im, HT; Lee, KT; Shin, JS | 1 |
| Deng, N; Hong, Y; Jin, HN; Qian, YX; Wu, ZY; Xie, W; Xuan, ZZ | 1 |
| Dong, J; Gao, L; Guo, S; Li, L; Li, R; Liang, C; Liu, Y; Yang, H; Zhao, X | 1 |
| Cao, Z; Chen, J; Feng, W; Guo, M; Pessah, IN; Wang, H; Zhang, C; Zhang, T; Zhao, F; Zheng, J; Zou, X | 1 |
| Huang, N; Li, X; Liu, R; Sun, R | 1 |
| Cai, H; Duan, Y; Liu, J; Niu, M; Pei, K; Shen, L; Tu, S; Xu, Y; Zhang, Y; Zhou, J; Zhou, Q | 1 |
| Cui, LH; Cui, NQ; Li, CX; Yang, L; Zhang, SK; Zhuo, YZ | 1 |
| Hu, SC; Lai, YC; Lin, CL; Tzeng, WS; Yen, FL | 1 |
| Hou, MC; Huang, YH; Lan, KH; Lan, KL; Lee, WP; Liao, SX | 1 |
| Chen, Y; Hou, X; Li, R; Lv, Y; Sun, R; Tian, Y; Xu, F; Xu, L; Zhang, Q; Zhang, Z | 1 |
| Chen, X; Peng, X; Rao, X; Zheng, C; Zhu, Y | 1 |
| Jian-Qing, S; Lian-Tao, L; Shuai-Cheng, W; Xiu-Ling, C; Zhen-Jiang, Y; Zong-Mei, W | 1 |
| Meng, LJ; Wang, N; Xia, YC; Yang, L; Zhang, LC; Zhou, F | 1 |
| Fu, R; Gao, L; Liu, J; Song, R; Xue, Y; Yang, X; Zhang, Z | 1 |
| Ge, F; Li, S; Liu, L; Lu, J; Shi, H; Xu, X; Yan, J; Zhang, C; Zhao, Y | 1 |
| Deng, X; Guo, L; Ma, S; Su, J; Wang, S; Xu, L | 1 |
| Cheng, L; Han, M; Ren, Y; Yang, L; Zhang, Q; Zhao, Y | 1 |
| Deng, X; Fu, Q; Fu, X; Ma, S; Ma, Z; Qin, T; Yu, J; Zhang, R | 1 |
| Feng, L; Liu, L; Zhao, R; Zhao, Y | 1 |
| Fu, R; Liu, J; Ren, S; Song, R; Sun, J; Xue, Y; Zhang, Z | 1 |
| Ding, L; Gao, FF; Gao, Y; He, X; He, YQ; Jiang, NH; Li, K; Ma, Q; Pan, WT; Song, WJ; Wei, L; Xu, XL; Zhang, JW | 1 |
| Fu, R; Liu, J; Song, R; Xue, Y; Zhang, Z | 1 |
| Gao, JJ; Han, LW; He, QX; Liu, KC; Tu, PF; Xia, Q; Zhang, SS; Zhang, Y | 1 |
| Ding, X; Ke, Z; Pan, Y; Shen, Y; Sun, L; Ye, H; Yuan, J; Zhang, R | 1 |
| Gao, ZH; Li, RF; Li, SQ; Li, YY; Liu, WY; Wang, HW; Wang, JG; You, M | 1 |
| Ali, H; Ali, J; Islam, SU; Khan, AU; Khan, S; Kim, YS; Shah, FA | 1 |
| Chai, OH; Lee, EJ; Piao, CH; Song, CH | 1 |
| Gao, J; Guan, X; Guo, J; Liu, B; Liu, S; Qin, Z; Tang, K; Wang, X; Zhang, F | 1 |
| Choi, J; Choi, Y; Kim, JK; Kim, P; Kim, S; Kim, WJ; Lee, G; Lee, JH; Lee, JK; Lee, JS; Nam, YJ; No, KT; Song, MJ | 1 |
| Cheng, N; Li, Y; Liu, J; Luo, J; Ren, D; Xin, H; Yang, J; Zhang, J; Zhang, X | 1 |
| Chao, B; Huang, S; Pan, J; Wang, Y; Zhang, Y | 1 |
| Huang, F; Li, XZ; Ma, SP; Pan, YW; Su, J; Wang, SQ | 1 |
| An, Y; Li, J; Li, M; Li, P; Ren, J; Wu, M; Xie, Y; Xiong, W; Xue, H; Yan, D; Zhong, G | 1 |
| Ke, Z; Li, X; Lian, D; Pan, Y; Yuan, J | 1 |
| Gurav, NS; Gurav, SS; Prasad, RS; Prasad, SK; Shakya, A; Singh, S; Sinha, SK | 1 |
| Bahbah, EI; Nabet, MS; Negida, A | 1 |
| Carai, MAM; Chin, YW; Colombo, G; Corelli, F; Fara, F; Gessa, GL; Kwon, HC; Lee, JH; Lorrai, I; Maccioni, P | 1 |
| Chen, J; Fu, R; Li, B; Li, Y; Li, Z; Ming, Y; Xing, H; Zhang, L | 1 |
| Cui, L; Cui, N; Li, C; Li, Y; Yang, L; Zhang, S; Zhuo, Y | 1 |
| Han, M; Lan, YM; Yang, L; Yang, LL; Yang, LM; Yang, X; Zhang, T; Zhao, Y | 1 |
| Botchway, BOA; Hu, S; Jiang, J; Liu, X; Meng, Y; Zhang, Y | 1 |
| Duan, Q; Kang, T; Liu, M; Naqvi, S; Wang, Z; Xiao, S; Zhang, F; Zhang, G; Zheng, Y | 1 |
| Goda, Y; Higano, T; Hosoe, J; Igarashi, Y; Ishizuki, K; Iwamoto, Y; Komatsu, T; Maruyama, T; Miura, T; Shimada, N; Suematsu, T; Sugimoto, N; Uchiyama, N; Yamada, Y | 2 |
| Chen, CI; Chen, CY; Cheng, HY; Huang, HH; Kuo, SM; Shiu, LY | 1 |
| Fan, M; Huang, N; Li, X; Liu, J; Qi, X; Sun, R; Zhang, X | 1 |
| Han, WJ; Sui, C; Wei, JH; Zhu, CR | 1 |
| Chen, W; Liu, K; Ren, F; Wu, H; Wu, S; Xu, F; Zheng, D | 1 |
| Chen, BL; Chen, SM; Hua, SC; Lee, JA; Lee, TH; Lin, CE; Lin, CY; Lin, PY; Tsai, PY | 1 |
| Han, J; Jiang, Y; Li, J; Lv, J; Qu, L; Wang, S | 1 |
| Li, H; Tang, F; Tang, Y; Wang, Y; Wei, W; Yin, C | 1 |
| Gao, H; Gao, S; Song, Y; Sun, H; Tang, K; Xie, G; Zhao, Y | 1 |
| Li, W; Liao, X; Liu, Y; Su, Y; Wang, Q; Xu, Y; Yu, Y; Zhang, J; Zhang, S; Zhao, M | 1 |
| Li, H; Tang, F; Tang, Y; Wei, W; Yin, C | 1 |
| Fan, M; Huang, N; Li, X; Liu, J; Qi, X; Sun, R | 1 |
| Ayyanar, M; Chikhale, R; Dey, YN; Gurav, NS; Gurav, SS; Khanal, P; Patil, RB; Prasad, S; Sinha, SK; Wanjari, M | 1 |
| Hu, MZ; Li, YB; Liu, B; Mi, LF; Wang, AR; Zhang, ZL; Zhao, ZY; Zheng, S | 1 |
| Guo, J; Lin, S; Ma, Q; Min, W; Song, L; Wang, B; Yang, P | 1 |
| Du, X; Hu, S; Liu, X; Ma, X; Shi, W; Xiao, X; Xu, P; Xue, N; Zheng, J; Zuo, G | 1 |
| Mu, T; Wang, Z; Wei, B; Xu, P; Yu, B | 1 |
| Luo, J; Sun, T; Sun, X; Xu, Y; Yang, M; Yang, S | 1 |
| Chen, Y; Li, Y; Lin, L; Liu, X; Que, R; Shi, Z; Zhang, K; Zhou, M | 1 |
| Liu, J; Liu, Q; Ren, S; Song, R; Xing, Y; Xu, J; Xue, Y; Yang, J; Zhang, Z | 1 |
| Guan, H; Han, H; Ju, Z; Li, G; Lin, J; Shi, M; Tang, J; Xu, Y; Zhang, T | 1 |
| Chen, G; Fu, Y; Yao, L; Yao, T; Zhang, L; Zhou, C | 1 |
| Chen, CR; Huang, ZL; Jiang, S; Qu, WM; Zhang, W; Zhong, YH | 1 |
| Cheng, T; Ying, M | 1 |
| Cao, J; Fang, C; Hao, G; He, Q; Hong, W; Qiu, Y; Shao, Y; Shi, Q; Song, L; Wang, J; Weng, Q; Yang, B; Yang, L; Yang, Z; Zhang, L | 1 |
| Du, QY; Guo, J; He, XY; Shi, W; Wang, F; Zhou, P | 1 |
| Chen, Y; Li, Y; Lin, L; Que, R; Zhang, N; Zhou, M | 1 |
| Choi, CI; Han, HK; Lee, HS; Lim, SH | 1 |
| Chen, H; Feng, L; He, Y; Hou, D; Wei, P; Yang, B; Yang, Y; Yu, M; Zhang, Y; Zhao, J | 1 |
| Chen, K; Gao, M; Jiang, H; Li, H; Ye, C; Yu, K | 1 |
| Chen, H; Chen, L; Fang, X; Lu, F; Song, X; Sun, J; Wu, X; Zhang, W; Zhao, K | 1 |
| Chen, XM; Cheng, YF; Jiang, W; Li, X; Luo, D; Pi, JK; Wang, XJ; Wang, XX; Wu, SS; Wu, Z; Xu, JY; Zhang, Y; Zhang, YJ; Zhou, JH | 1 |
| Du, J; Huang, X; Li, B; Li, L; Li, Y; Liu, J; Song, D | 1 |
| Miao, H; Pan, J; Shen, N; Xing, L; Yu, X; Zhang, H; Zou, L | 1 |
| Huang, W; Liu, J; Luo, J; Tan, W; Wang, J; Xin, H; Yang, J | 1 |
| Gao, J; Guo, X; Han, W; Sui, C; Wan, H; Wei, J; Wu, B; Xu, J; Zhou, L | 1 |
| Chen, BL; Wang, P; Wen, XQ; Wu, WW; Yu, CL; Zhang, HY; Zhang, JW; Zhang, MY; Zhang, Y; Zhou, Q; Zhuang, M | 1 |
| Ahn, SS; Jung, E; Lee, YH; Lim, Y; Shin, SY; Yeo, H | 1 |
| Im, WT; Kim, JH; Lee, JE; Siddiqi, MZ; Song, BK | 1 |
| Ding, M; Duan, S; Fan, G; Gu, Y; Li, X; Li, Y; Liu, C; Liu, R; Sun, R; Zheng, Q | 1 |
| Jiao, ZY; Xiao, LX; Zhou, HN | 1 |
| Du, G; Gao, X; Hou, R; Li, X; Qin, X; Tian, J; Wu, X; Wu, Y; Zhou, Y | 1 |
| Dong, C; Ji, B; Qiao, L; Su, X; Yang, L | 1 |
| Huang, Q; Li, LL; Peng, DY; Qi, JJ; Yao, M | 1 |
| Chen, Y; Cui, N; Hu, B; Kuang, H; Peng, D; Qi, Y; Sun, Y; Wang, Q; Yang, B; Zeng, Y; Zhang, W; Zhang, Z | 1 |
| Jiang, L; Khan, MR; Ni, ZJ; Tang, TT; Thakur, K; Wei, ZJ; Zhong, Q | 1 |
| DU, XW; Hou, BY; Wang, WX; Yu, D; Zhu, HR | 1 |
| Lai, Y; Zhu, Y | 1 |
| Chang, Y; Liu, S; Tian, L; Wang, Z; Xiao, Y; Xiu, Y; Zhao, H; Zhao, M; Zhou, Y | 1 |
14 review(s) available for oleanolic acid and saikosaponin d
| Article | Year |
|---|---|
[Advances in the study on medicament portions of caihu].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupleurum; Flavonoids; Humans; Oils, Volatile; Oleanolic Acid; Plant Components, Aerial; Plant Roots; Plants, Medicinal; Saponins; Species Specificity | 1999 |
[Progress in research on antitumor activity of saikosaponin and its mechanism].
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cyclooxygenase 2 Inhibitors; Drugs, Chinese Herbal; Humans; Oleanolic Acid; Saponins | 2006 |
[Advances in mechanisms of saikosaponins in preventing and treating liver disease].
Topics: Humans; Liver Diseases; Oleanolic Acid; Phytotherapy; Saponins | 2009 |
Saikosaponins: a potential treatment option for systemic lupus erythematosus.
Topics: Animals; Autoimmune Diseases; Humans; Immunosuppressive Agents; Lupus Vasculitis, Central Nervous System; Oleanolic Acid; Saponins | 2011 |
Putative genes involved in saikosaponin biosynthesis in Bupleurum species.
Topics: Biosynthetic Pathways; Bupleurum; Gene Expression Regulation, Plant; Genes, Plant; Oleanolic Acid; Phylogeny; Saponins | 2013 |
A systematic review of the active saikosaponins and extracts isolated from Radix Bupleuri and their applications.
Topics: Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antiviral Agents; Bupleurum; Drugs, Chinese Herbal; Humans; Immunologic Factors; Neurotransmitter Agents; Oleanolic Acid; Phytotherapy; Plants, Medicinal; Saponins | 2017 |
Saikosaponins: a review of pharmacological effects.
Topics: Bupleurum; Drugs, Chinese Herbal; Humans; Molecular Structure; Oleanolic Acid; Plant Roots; Saponins | 2018 |
The Role of Saikosaponins in Therapeutic Strategies for Age-Related Diseases.
Topics: Apoptosis; Cardiovascular Diseases; Cell Cycle Checkpoints; Humans; Liver Diseases; Neoplasms; Neurodegenerative Diseases; Obesity; Oleanolic Acid; Oxidative Stress; Saponins | 2018 |
A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Antiviral Agents; Apoptosis; Bupleurum; China; Drugs, Chinese Herbal; Fibrosis; Humans; Liver; Oleanolic Acid; Oxidative Stress; Plant Extracts; Saponins | 2018 |
Saikosaponin D: A potential therapeutic drug for osteoarthritis.
Topics: Autophagy; Humans; NF-kappa B; Oleanolic Acid; Osteoarthritis; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Recent Progress in Saikosaponin Biosynthesis in Bupleurum.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupleurum; Drugs, Chinese Herbal; Flavonoids; Humans; Oleanolic Acid; Plant Roots; Saponins; Species Specificity | 2021 |
Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Bupleurum; Cell Differentiation; Humans; Neoplasms; Oleanolic Acid; Saponins | 2021 |
Present and Future Prospects of the Anti-cancer Activities of Saikosaponins.
Topics: Drugs, Chinese Herbal; Humans; Neoplasms; Oleanolic Acid; Saponins | 2022 |
Pharmacological properties and derivatives of saikosaponins-a review of recent studies.
Topics: Anti-Inflammatory Agents; Antiviral Agents; COVID-19; Humans; Oleanolic Acid; Saponins; SARS-CoV-2 | 2023 |
1 trial(s) available for oleanolic acid and saikosaponin d
| Article | Year |
|---|---|
Saikosaponin A protects chickens against pullorum disease via modulation of cholesterol.
Topics: Animals; Anticholesteremic Agents; Bupleurum; Chickens; Cholesterol; Oleanolic Acid; Poultry Diseases; Protective Agents; Random Allocation; Salmonella enterica; Salmonella Infections, Animal; Saponins | 2019 |
384 other study(ies) available for oleanolic acid and saikosaponin d
| Article | Year |
|---|---|
[The identification and determination of marker substances in xiaoyao wan by three dimensional HPLC].
Topics: Benzoates; Bridged-Ring Compounds; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Glucosides; Glycyrrhetinic Acid; Glycyrrhizic Acid; Monoterpenes; Oleanolic Acid; Sapogenins; Saponins | 1992 |
[A histochemical study of saikosaponins].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drugs, Chinese Herbal; Histocytochemistry; Immunosuppressive Agents; Oleanolic Acid; Sapogenins; Saponins | 1992 |
Inactivation of measles virus and herpes simplex virus by saikosaponin d.
Topics: Animals; Antiviral Agents; Carbohydrate Sequence; Cell Division; Measles virus; Molecular Sequence Data; Oleanolic Acid; Sapogenins; Saponins; Vero Cells; Virus Replication | 1992 |
Effects of saikosaponin-d on the functions and morphology of macrophages.
Topics: Animals; Cell Movement; Cytoskeleton; Injections, Intramuscular; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Morphogenesis; Oleanolic Acid; Peritoneal Lavage; Phagocytosis; Sapogenins; Saponins | 1991 |
Effect of saikosaponin on the immune responses in mice.
Topics: Animals; Cell Division; Hemolytic Plaque Technique; Immunity; Injections, Intramuscular; Interleukin-1; Lymphocyte Activation; Lysosomes; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Peritoneal Lavage; Phagocytosis; Sapogenins; Saponins; Spleen | 1991 |
Evaluation of root quality of Bupleurum species by TLC scanner and the liver protective effects of "xiao-chai-hu-tang" prepared using three different Bupleurum species.
Topics: Animals; Calibration; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromatography, Thin Layer; Drugs, Chinese Herbal; Liver; Liver Diseases; Male; Oleanolic Acid; Plant Extracts; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1991 |
[Dynamic variation of saikosaponin contents].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Immunosuppressive Agents; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins; Spectrophotometry, Ultraviolet; Time Factors | 1991 |
The effects of saikosaponin on macrophage functions and lymphocyte proliferation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cells, Cultured; Chemotaxis, Leukocyte; Immunosuppressive Agents; Lymphocytes; Macrophages; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Phagocytosis; Plants; Sapogenins; Saponins | 1991 |
The effects of saikosaponin-d on yeast phagocytosis and degradation in peritoneal macrophages: related increase in Fc receptor expression and altered cytoplasmic organization.
Topics: Acid Phosphatase; Animals; Cytoplasm; Macrophages; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Oleanolic Acid; Peritoneal Cavity; Phagocytosis; Receptors, Fc; Sapogenins; Saponins; Yeasts | 1991 |
Inhibition of platelet activation and endothelial cell injury by flavan-3-ol and saikosaponin compounds.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catechin; Cattle; Cells, Cultured; Endothelium, Vascular; Flavonoids; Humans; Hydrogen Peroxide; Oleanolic Acid; Platelet Aggregation; Platelet Aggregation Inhibitors; Sapogenins; Saponins; Thromboxane B2 | 1991 |
[Studies on antinephritic effects of plant components in rats (1). Effects of saikosaponins original-type anti-GBM nephritis in rats and its mechanisms].
Topics: Animals; Cholesterol; Corticosterone; Free Radical Scavengers; Glomerulonephritis; Glutathione Peroxidase; Kidney; Male; Oleanolic Acid; Platelet Aggregation; Platelet Aggregation Inhibitors; Proteinuria; Rats; Rats, Inbred Strains; Sapogenins; Saponins; Superoxide Dismutase | 1991 |
A distinct characteristic of the quiescent state of human dermal fibroblasts in contracted collagen gel as revealed by no response to epidermal growth factor alone, but a positive growth response to a combination of the growth factor and saikosaponin b1.
Topics: Adult; Cell Division; Cells, Cultured; Collagen; Contact Inhibition; Drug Synergism; Epidermal Growth Factor; ErbB Receptors; Female; Fibroblasts; Gels; Humans; Infant, Newborn; Male; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins; Signal Transduction; Skin | 1990 |
Protective effect of saikosaponin A, saikosaponin D and saikogenin D against Pseudomonas aeruginosa infection in mice.
Topics: Animals; Injections, Intraperitoneal; Listeriosis; Mice; Oleanolic Acid; Pseudomonas Infections; Sapogenins; Saponins | 1990 |
Simultaneous determination of ginsenosides and saikosaponins by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Ginsenosides; Glycyrrhiza; Immunosuppressive Agents; Oleanolic Acid; Panax; Plants; Plants, Medicinal; Sapogenins; Saponins | 1990 |
Corticosterone secretion-inducing activity of saikosaponin metabolites formed in the alimentary tract.
Topics: Animals; Biotransformation; Corticosterone; Digestive System; Male; Mice; Oleanolic Acid; Sapogenins; Saponins; Stimulation, Chemical | 1989 |
[Determination of saikosaponins in radix Bupleuri using HPLC].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Sapogenins; Saponins; Species Specificity | 1989 |
Effects of saikosaponin metabolites on the hemolysis of red blood cells and their adsorbability on the cell membrane.
Topics: Adsorption; Erythrocyte Membrane; Hemolysis; Humans; In Vitro Techniques; Oleanolic Acid; Sapogenins; Saponins | 1989 |
[Advances in research on the chemistry of saponins in Bupleurum].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chemical Phenomena; Chemistry; Immunosuppressive Agents; Molecular Conformation; Oleanolic Acid; Sapogenins; Saponins | 1989 |
Activation of murine peritoneal macrophages by saikosaponin a, saikosaponin d and saikogenin d.
Topics: Animals; Female; Histocompatibility Antigens Class II; Injections, Intraperitoneal; Lysosomes; Macrophage Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins | 1989 |
Effects of saikosaponin-d on enhanced CCl4-hepatotoxicity by phenobarbitone.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Carbon Tetrachloride Poisoning; Drug Synergism; Enzyme Induction; Lipid Peroxides; Liver; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oleanolic Acid; Phenobarbital; Rats; Rats, Inbred Strains; Sapogenins; Saponins; Time Factors | 1985 |
Effects of saikosaponins on liver tyrosine aminotransferase activity induced by cortisone in adrenalectomized rats.
Topics: Adrenalectomy; Animals; Cortisone; Enzyme Induction; Liver; Male; Oleanolic Acid; Rats; Rats, Inbred Strains; Sapogenins; Saponins; Tyrosine Transaminase | 1985 |
[Comparison on saikosaponin levels in the root of Bupleurum chinense of various sizes].
Topics: Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins; Time Factors | 1985 |
[Variation of saponins for Bupleurm scorzonerifolium and B. chinese in the extraction process and their effect on hemolysis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Hemolysis; Hot Temperature; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1985 |
An investigation of the immune suppression induced by some saikosaponin derivatives.
Topics: Animals; Antibodies, Monoclonal; Antilymphocyte Serum; Drugs, Chinese Herbal; Female; Immunization, Passive; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Oleanolic Acid; Sapogenins; Saponins; Spleen; T-Lymphocytes, Regulatory | 1988 |
[Comparative studies on the roots of wild and cultured Bupleurum chinense DC].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drugs, Chinese Herbal; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1988 |
Effect of chronic treatment with saikosaponin d and dexamethasone on responsiveness of pituitary and adrenal cortex and adrenal weight in rats.
Topics: Adrenal Cortex; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dexamethasone; Male; Oleanolic Acid; Organ Size; Pituitary Gland; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1987 |
Studies of the combined use of steroid and Shosaikoto, one of the Kampohozai (Chinese traditional medicine), on pituitary adrenocortical axis function and immune responses.
Topics: Adrenal Glands; Animals; Body Weight; Corticosterone; Drugs, Chinese Herbal; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hemagglutinins; Hemolytic Plaque Technique; Immunity; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Organ Size; Pituitary-Adrenal System; Plant Extracts; Plants, Medicinal; Prednisolone; Rats; Rats, Inbred Strains; Rosette Formation; Sapogenins; Saponins; Spleen | 1986 |
Purification of saikosaponins a, c and d. Application of large-scale reversed high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Japan; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1987 |
Chronic effect of saikosaponin on adrenal and thymus growth in normal and dexamethasone-treated rats.
Topics: Adrenal Glands; Animals; Body Weight; Dexamethasone; Male; Oleanolic Acid; Organ Size; Rats; Rats, Inbred Strains; Sapogenins; Saponins; Thymus Gland | 1986 |
Pharmacological effects of oral saikosaponin a may differ depending on conditions of the gastrointestinal tract.
Topics: Animals; Intestinal Absorption; Liver; Male; Oleanolic Acid; Protein Biosynthesis; Rats; Sapogenins; Saponins | 1986 |
Effect of saikosaponin derivatives upon the immune response against T-dependent and T-independent antigens in mice.
Topics: Animals; Antibody-Producing Cells; Antigens, T-Independent; Erythrocytes; Female; Hemolytic Plaque Technique; Immunity; Immunosuppressive Agents; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Sapogenins; Saponins; Sheep; T-Lymphocytes | 1985 |
Pharmacological influence of saikosaponins on prostaglandin E2 production by peritoneal macrophages.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dinoprostone; In Vitro Techniques; Macrophages; Male; Mice; Muscle Contraction; Muscle, Smooth; Oleanolic Acid; Prostaglandins E; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1985 |
Effects of saikosaponin-d on aminonucleoside nephrosis in rats.
Topics: Animals; Blood Proteins; Cholesterol; Female; Kidney; Microscopy, Electron, Scanning; Nephrosis; Oleanolic Acid; Proteinuria; Puromycin; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1986 |
Interaction of saponin of bupleuri radix with ginseng saponin: solubilization of saikosaponin-a with chikusetsusaponin V (= ginsenoside-Ro).
Topics: Animals; Chemical Phenomena; Chemistry; Ginsenosides; Hemolysis; In Vitro Techniques; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins; Sheep | 1985 |
Structural transformation of saikosaponins by gastric juice and intestinal flora.
Topics: Animals; Bacteria; Biotransformation; Chromatography, High Pressure Liquid; Fasting; Feces; Gastric Acid; In Vitro Techniques; Intestines; Kinetics; Mice; Oleanolic Acid; Rats; Sapogenins; Saponins | 1985 |
[Anti-inflammatory effect of saikosaponins (author's transl)].
Topics: Animals; Anti-Inflammatory Agents; Cell Migration Inhibition; Edema; Granuloma; Histamine Release; Oleanolic Acid; Rats; Sapogenins; Saponins | 1981 |
[Research on the pharmacology of Bupleurum chinensis].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Humans; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Mice; Oleanolic Acid; Plants, Medicinal; Rats; Sapogenins; Saponins | 1983 |
[Comparison of the quality of cultivated and wild Bupleurum chinensis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Sapogenins; Saponins | 1983 |
The anti-allergic inflammation action of Saikosaponins.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Female; Hypersensitivity; Hypersensitivity, Delayed; Male; Mice; Oleanolic Acid; Passive Cutaneous Anaphylaxis; Rats; Sapogenins; Saponins | 1983 |
Effects of saikosaponins on the metabolic actions of adrenaline, ACTH and insulin on the fat cells.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Animals; Epinephrine; In Vitro Techniques; Insulin; Male; Oleanolic Acid; Rats; Sapogenins; Saponins | 1980 |
[Determination of saikosaponins in Chinese medicinal extracts containing Bupleuri radix].
Topics: Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Sapogenins; Saponins | 1984 |
[Preventive and therapeutic actions of glycyrrhizin, glycyrrhetic acid and crude saikosides on experimental liver cirrhosis in rats].
Topics: Animals; Collagen; Fatty Liver; Female; Glycyrrhetinic Acid; Glycyrrhizic Acid; Hepatitis; Liver Cirrhosis; Male; Oleanolic Acid; Rats; Sapogenins; Saponins | 1983 |
Quantitative analysis of the metabolites of saikosaponin a using high-performance liquid chromatography.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Male; Mice; Oleanolic Acid; Sapogenins; Saponins; Time Factors | 1984 |
Effect of saikosaponins on dexamethasone suppression of the pituitary-adrenocortical system.
Topics: Animals; Corticosterone; Dexamethasone; Male; Oleanolic Acid; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1984 |
Protective effect of saikosaponin-d isolated from Bupleurum falcatum L. on CCl4-induced liver injury in the rat.
Topics: Animals; Body Weight; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Lipid Peroxides; Male; Microsomes, Liver; Necrosis; Oleanolic Acid; Organ Size; Plants, Medicinal; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1982 |
[Pharmacological studies on a prescription containing Bupleuri Radix (IV). Effects of saikosaponin on the anti-inflammatory action of glucocorticoid].
Topics: Animals; Body Weight; Dexamethasone; Drug Combinations; Drug Therapy, Combination; Granuloma; Injections, Intramuscular; Lipids; Male; Oleanolic Acid; Organ Size; Plants, Medicinal; Rats; Rats, Inbred Strains; Sapogenins; Saponins | 1982 |
Pharmacological actions of saikosaponins isolated from Bupleurum falcatum. 1. Effects of saikosaponins on liver function.
Topics: Animals; In Vitro Techniques; Liver; Male; Microsomes, Liver; Oleanolic Acid; Plants, Medicinal; Rats; Sapogenins; Saponins | 1980 |
Erythrocyte membrane stabilization by plant saponins and sapogenins.
Topics: Animals; Erythrocyte Membrane; Erythrocytes; Hemolysis; Hot Temperature; In Vitro Techniques; Male; Oleanolic Acid; Osmolar Concentration; Rats; Sapogenins; Saponins; Structure-Activity Relationship | 1981 |
Stimulation of the pituitary-adrenocortical axis by saikosaponin of Bupleuri radix.
Topics: Animals; Male; Oleanolic Acid; Pituitary-Adrenal System; Plants, Medicinal; Rats; Sapogenins; Saponins; Stimulation, Chemical | 1981 |
Chemical structures and corticosterone secretion-inducing activities of saikosaponins.
Topics: Animals; Chemical Phenomena; Chemistry; Corticosterone; Male; Oleanolic Acid; Rats; Sapogenins; Saponins; Stimulation, Chemical | 1981 |
Effects of saikosaponins on biological membranes. 3. Ultrastructural studies on effects of saikosaponins on the cell surface.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Membrane; Cells, Cultured; Mice; Oleanolic Acid; Sapogenins; Saponins; Surface Properties | 1981 |
Analgesic and other pharmacologic actions of saiko-saponin in repeated cold stressed (SART stressed) animals.
Topics: Acetylcholine; Analgesics; Animals; Behavior, Animal; Body Weight; Cold Temperature; Galvanic Skin Response; Male; Mice; Muscle Contraction; Oleanolic Acid; Rats; Sapogenins; Saponins; Sleep; Stress, Physiological | 1980 |
Studies on the agronomic characteristics, yield, and saikosaponin content of two Bupleurum species in Taiwan.
Topics: Bupleurum; Drugs, Chinese Herbal; Germination; Immunosuppressive Agents; Oleanolic Acid; Plant Extracts; Plant Roots; Sapogenins; Saponins; Seeds; Time Factors | 1995 |
Cell type-oriented differential modulatory actions of saikosaponin-d on growth responses and DNA fragmentation of lymphocytes triggered by receptor-mediated and receptor-bypassed pathways.
Topics: Animals; Antibodies, Monoclonal; Calcimycin; Cell Division; Cells, Cultured; DNA Damage; Down-Regulation; Interleukin-2; Interleukin-4; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Oleanolic Acid; Receptors, Immunologic; Sapogenins; Saponins; Signal Transduction; Spleen; T-Lymphocytes; Thymus Gland; Up-Regulation | 1995 |
Anti-growth effects with components of Sho-saiko-to (TJ-9) on cultured human hepatoma cells.
Topics: alpha-Fetoproteins; Antineoplastic Agents; Astringents; Carcinoma, Hepatocellular; Cell Cycle; Cell Death; Cell Division; DNA, Neoplasm; Drugs, Chinese Herbal; Flavanones; Flavonoids; Ginsenosides; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Liver Neoplasms; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins; Tumor Cells, Cultured | 1993 |
Anti-inflammatory activity of saikosaponins from Heteromorpha trifoliata.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbohydrate Sequence; Female; Malawi; Mice; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1995 |
Saikosaponin A-induced cell death of a human hepatoma cell line (HuH-7): the significance of the 'sub-G1 peak' in a DNA histogram.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Death; Cell Nucleus; DNA, Neoplasm; Electrophoresis, Agar Gel; Flow Cytometry; Humans; Liver Neoplasms; Mitochondrial Swelling; Necrosis; Oleanolic Acid; Sapogenins; Saponins; Tumor Cells, Cultured | 1995 |
Characterization of the immunoregulatory action of saikosaponin-d.
Topics: Adjuvants, Immunologic; Animals; Blotting, Northern; Cell Division; Fluorescent Antibody Technique; Genes, fos; Glycyrrhetinic Acid; Glycyrrhizic Acid; Immunosuppressive Agents; Interleukin-2; Mice; Mice, Inbred C57BL; Oleanolic Acid; Phosphorylation; Receptors, Interleukin-2; Sapogenins; Saponins; Signal Transduction; Spleen; T-Lymphocytes; Tyrosine; Up-Regulation | 1994 |
Comparison between the effects of crude saikosaponin and 16, 16-dimethyl prostaglandin E2 on tannic acid-induced gastric mucosal damage in rats.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diffusion; Electrolytes; Gastric Acid; Gastric Mucosa; Hydrolyzable Tannins; Male; Oleanolic Acid; Permeability; Rats; Rats, Sprague-Dawley; Sapogenins; Saponins; Stomach Ulcer; Vagotomy | 1993 |
[Isolation and identification of two new saponins from Bupleurum smithii Wolff].
Topics: Drugs, Chinese Herbal; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins | 1993 |
Scrophulasaponins II-IV, new saikosaponin homologs from Scrophularia kakudensis FRANCH.
Topics: Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plants; Sapogenins; Saponins | 1993 |
Effects of saiboku-to (TJ-96) on the production of platelet-activating factor in human neutrophils.
Topics: Drugs, Chinese Herbal; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Immunosuppressive Agents; Medicine, Kampo; Neutrophils; Oleanolic Acid; Platelet Activating Factor; Sapogenins; Saponins | 1993 |
[Production of medicinal plants by soilless culture system. I. Studies of morphological characteristics and saikosaponins content in Bupleurum falcatum cultivated by Ebb & Flood system].
Topics: Botany; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sapogenins; Saponins | 1995 |
Central administration of saikosaponin-d increases corticotropin-releasing factor mRNA levels in the rat hypothalamus.
Topics: Adrenocorticotropic Hormone; Animals; Brain; Corticotropin-Releasing Hormone; Hypothalamus; Injections, Intraventricular; Male; Oleanolic Acid; Pituitary Gland, Anterior; Pro-Opiomelanocortin; Rats; Rats, Wistar; RNA, Messenger; Sapogenins; Saponins | 1995 |
Saikosaponin b2-induced apoptosis of cultured B16 melanoma cell line through down-regulation of PKC activity.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line; Cell Nucleus; DNA, Neoplasm; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; Kinetics; Melanoma, Experimental; Mice; Oleanolic Acid; Protein Kinase C; Sapogenins; Saponins; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Effects of nine active ingredients in Chinese herbal medicine sho-saiko-to on 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide mutagenicity.
Topics: Animals; Antimutagenic Agents; Biotransformation; DNA Repair; Drugs, Chinese Herbal; Flavanones; Flavonoids; Furylfuramide; Ginsenosides; Male; Molecular Structure; Mutagenicity Tests; Mutagens; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Salmonella typhimurium; Sapogenins; Saponins | 1995 |
Suppressive effects of sairei-to on monoclonal antibody 1-22-3-induced glomerulonephritis: analysis of effective components.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Blood Chemical Analysis; Drugs, Chinese Herbal; Female; Glomerulonephritis; Kidney; Oleanolic Acid; Proteinuria; Rats; Rats, Wistar; Sapogenins; Saponins | 1997 |
Saikosaponin homologues from Clinopodium spp. The structures of clinoposaponins XII-XX.
Topics: Carbohydrate Conformation; Magnetic Resonance Spectroscopy; Oleanolic Acid; Sapogenins; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1997 |
Saikosaponin homologues from Verbascum spp. The structures of mulleinsaponins I-VII.
Topics: Carbohydrate Sequence; Carbohydrates; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Sapogenins; Saponins; Terminology as Topic | 1997 |
Enzymes responsible for the metabolism of saikosaponins from Eubacterium sp. A-44, a human intestinal anaerobe.
Topics: alpha-L-Fucosidase; Anti-Inflammatory Agents, Non-Steroidal; Culture Media; Eubacterium; Feces; Glucosidases; Humans; Hydrogen-Ion Concentration; Intestines; Molecular Weight; Oleanolic Acid; Sapogenins; Saponins; Substrate Specificity | 1997 |
Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cardiac Glycosides; Catecholamines; Cattle; Central Nervous System Agents; Chromaffin Cells; Dose-Response Relationship, Drug; Ginsenosides; Glycyrrhizic Acid; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins | 1998 |
Metabolism and pharmacokinetics of orally administered saikosaponin b1 in conventional, germ-free and Eubacterium sp. A-44-infected gnotobiote rats.
Topics: Animals; Anti-Allergic Agents; Antineoplastic Agents, Phytogenic; Eubacterium; Feces; Gastrointestinal Contents; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Oleanolic Acid; Permeability; Rats; Rats, Wistar; Sapogenins; Saponins | 1998 |
ELISA for the determination of saikosaponin a, an active component of Bupleuri Radix.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibody Specificity; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Oleanolic Acid; Ovalbumin; Plants, Medicinal; Rabbits; Sapogenins; Saponins | 1998 |
In vivo and in vitro antiinflammatory activity of saikosaponins.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Carbohydrate Sequence; Cell Survival; Cells, Cultured; Dinoprostone; Ear, External; Edema; Female; Humans; Leukotriene C4; Macrophages, Peritoneal; Male; Mice; Molecular Sequence Data; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Sapogenins; Saponins; Tetradecanoylphorbol Acetate | 1998 |
[The structure activity relationship of saikosaponins and glycyrrhizin derivatives for Na+, K(+)-ATPase inhibiting action].
Topics: Cell-Free System; Glycyrrhizic Acid; Humans; Oleanolic Acid; Sapogenins; Saponins; Sodium-Potassium-Exchanging ATPase; Structure-Activity Relationship | 1996 |
[Chemical constituents of the roots of Bupleurum longicaule Wall. ex DC. var. franchetii de Boiss and B. chaishoui Shan et Sheh].
Topics: Apiaceae; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sapogenins; Saponins | 1996 |
Saikosaponin b2 induces differentiation without growth inhibition in cultured B16 melanoma cells.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Size; Fluorescent Antibody Technique; Melanins; Melanoma, Experimental; Mice; Monophenol Monooxygenase; Neoplasm Transplantation; Oleanolic Acid; Sapogenins; Saponins; Tumor Cells, Cultured | 1998 |
Production of antibody against saikosaponin a, an active component of bupleuri radix.
Topics: Animals; Antibodies; Carbohydrate Sequence; Cattle; Culture Media; Haptens; Immunosuppressive Agents; Molecular Sequence Data; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins; Serum Albumin, Bovine | 1998 |
Saikosaponins from roots of Bupleurum scorzonerifolium.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbohydrate Conformation; Carbohydrate Sequence; China; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sapogenins; Saponins | 1999 |
Antagonism of saikosaponin-induced prostaglandin E2 release by baicalein in C6 rat glioma cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Drug Antagonism; Flavanones; Flavonoids; Glioma; Oleanolic Acid; Prostaglandin Antagonists; Rats; Sapogenins; Saponins; Tumor Cells, Cultured | 1999 |
High-performance liquid chromatographic analysis of saponin compounds in Bupleurum falcatum.
Topics: Chromatography, High Pressure Liquid; Magnoliopsida; Oleanolic Acid; Plant Roots; Quality Control; Reproducibility of Results; Sapogenins; Saponins | 2000 |
Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bcl-2 mRNA.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Caspase Inhibitors; Cell Survival; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Humans; In Situ Nick-End Labeling; Lymphocyte Count; Lymphocytes; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sapogenins; Saponins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2000 |
Saikosaponin v-1 from roots of Bupleurum chinense DC.
Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents, Non-Steroidal; Bupleurum; China; Drugs, Chinese Herbal; Magnetic Resonance Spectroscopy; Molecular Structure; Oleanolic Acid; Plant Roots; Plants, Medicinal; Sapogenins; Saponins; Triterpenes | 2001 |
Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Carrier Proteins; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Liver Neoplasms; Oleanolic Acid; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sapogenins; Saponins; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2001 |
[Advances in the study of anti-inflammatory and immunoregulatory effects of saikosaponins and their similar substances].
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drugs, Chinese Herbal; Oleanolic Acid; Sapogenins; Saponins | 1998 |
Purification of saponin compounds in Bupleurum falcatum by solvent partitioning and preparative LC.
Topics: Bupleurum; Chromatography, Liquid; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins; Solvents | 2001 |
[Saponins in Bupleurum smithii Wolff var. parvifolium Shan et Y. Li].
Topics: Bupleurum; Drugs, Chinese Herbal; Molecular Structure; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1998 |
[Saikosaponin-d up-regulates GR mRNA expression and induces apoptosis in HL-60 cells].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; HL-60 Cells; Humans; Oleanolic Acid; Receptors, Glucocorticoid; RNA, Messenger; Sapogenins; Saponins; Up-Regulation | 1999 |
Inhibitory role of GDP on saikosaponin (I) stimulated enzymes secretion and rising of [Ca2+]i in rat pancreatic acini.
Topics: Animals; Calcium; Cells, Cultured; Guanosine Diphosphate; Male; Oleanolic Acid; Pancreas; Pancreatin; Rats; Saponins | 2001 |
Efficient production of saikosaponins in Bupleurum falcatum root fragments combined with signal transducers.
Topics: Acetates; Calcium Chloride; Cyclopentanes; Oleanolic Acid; Oxylipins; Plants; Sapogenins; Saponins; Signal Transduction; Structure-Activity Relationship | 2001 |
[Effect of Saikosaponin-d on up-regulating GR mRNA expression and inhibiting cell growth in human leukemia cells].
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Division; HL-60 Cells; Humans; Oleanolic Acid; Receptors, Glucocorticoid; RNA, Messenger; Sapogenins; Saponins; Up-Regulation | 2000 |
Antiviral activity of seven iridoids, three saikosaponins and one phenylpropanoid glycoside extracted from Bupleurum rigidum and Scrophularia scorodonia.
Topics: Animals; Antiviral Agents; Bupleurum; Carbohydrate Sequence; Cell Line; Chlorocebus aethiops; Cricetinae; Dose-Response Relationship, Drug; Glucosides; HeLa Cells; Herpesvirus 1, Human; Humans; Iridoids; Medicine, Traditional; Molecular Sequence Data; Oleanolic Acid; Phenols; Plant Extracts; Poliovirus; Pyrans; Sapogenins; Saponins; Scrophulariaceae; Vero Cells; Vesicular stomatitis Indiana virus | 2002 |
Induction of differentiation in rat C6 glioma cells with Saikosaponins.
Topics: 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase; Animals; Antineoplastic Agents, Phytogenic; Bupleurum; Cell Differentiation; Cell Division; Dose-Response Relationship, Drug; Glioma; Glutamate-Ammonia Ligase; Medicine, Chinese Traditional; Oleanolic Acid; Phosphoric Diester Hydrolases; Plant Extracts; Plant Roots; Rats; Sapogenins; Saponins; Tumor Cells, Cultured | 2002 |
[A new saikosaponin from Bupleurum Chinese DC].
Topics: Bupleurum; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins | 1998 |
[A new saikosaponin from Bupleurum chinense DC].
Topics: Bupleurum; Molecular Structure; Oleanolic Acid; Sapogenins; Saponins; Triterpenes | 1998 |
Characteristics and mechanism of enzyme secretion and increase in [Ca2+]i in Saikosaponin(I) stimulated rat pancreatic acinar cells.
Topics: Amylases; Animals; Calcium; Drugs, Chinese Herbal; In Vitro Techniques; Male; Oleanolic Acid; Pancreas; Rats; Rats, Wistar; Sapogenins; Saponins; Sincalide | 2002 |
Effect of saikosaponin-A, a triterpenoid glycoside, isolated from Bupleurum falcatum on experimental allergic asthma.
Topics: Animals; Anti-Allergic Agents; Asthma; Bronchoconstriction; Bupleurum; Dose-Response Relationship, Drug; Guinea Pigs; Histamine Antagonists; Histamine Release; In Vitro Techniques; Male; Molecular Structure; Muscle, Smooth; Oleanolic Acid; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Rats, Wistar; Sapogenins; Saponins; Time Factors; Trachea | 2002 |
[Studies on technology of supercritical-CO2 fluid extraction for volatile oils and saikosaponins in Bupleurum chinense DC].
Topics: Bupleurum; Carbon Dioxide; Chromatography, Supercritical Fluid; Oils, Volatile; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2000 |
ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a.
Topics: Activating Transcription Factor 2; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Division; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Depression, Chemical; Electrophoresis, Capillary; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Genes, p16; Humans; JNK Mitogen-Activated Protein Kinases; Liver Neoplasms; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Saponins; Tetradecanoylphorbol Acetate; Time Factors; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2003 |
Antiproliferative constituents from Umbelliferae plants VI. New ursane-type saikosaponin analogs from the fruits of Bupleurum rotundifolium.
Topics: Animals; Apiaceae; Bupleurum; Fruit; Growth Inhibitors; Humans; Mice; Oleanolic Acid; Plant Extracts; Saponins; Tumor Cells, Cultured | 2003 |
Saikosaponin-A induces apoptotic mechanism in human breast MDA-MB-231 and MCF-7 cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Biomarkers, Tumor; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Female; Genistein; Humans; Oleanolic Acid; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Saponins; Time Factors; Tumor Cells, Cultured | 2003 |
Cytotoxicity and anti-hepatitis B virus activities of saikosaponins from Bupleurum species.
Topics: Antineoplastic Agents, Phytogenic; Antiviral Agents; Blotting, Western; Bupleurum; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Primers; DNA, Viral; Hepatitis B virus; Humans; Oleanolic Acid; Phytotherapy; Plant Extracts; Polymerase Chain Reaction; Saponins | 2003 |
[Effect of chailing decoction and its active ingredients on experimental nephritis in rats].
Topics: Animals; Antibodies, Monoclonal; Drugs, Chinese Herbal; Female; Nephritis; Oleanolic Acid; Proteinuria; Rats; Rats, Wistar; Saponins | 2003 |
Development of an assay system for saikosaponin a using anti-saikosaponin a monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Bupleurum; Carrier Proteins; Chromatography, High Pressure Liquid; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Haptens; In Situ Hybridization; Medicine, Kampo; Mice; Mice, Inbred BALB C; Oleanolic Acid; Plant Roots; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
The proliferative inhibition and apoptotic mechanism of Saikosaponin D in human non-small cell lung cancer A549 cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Division; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA, Neoplasm; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Lung Neoplasms; Medicine, Chinese Traditional; Membrane Glycoproteins; Oleanolic Acid; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reagent Kits, Diagnostic; Saponins; Tumor Suppressor Protein p53 | 2004 |
Determination of saikosaponin derivatives in Radix bupleuri and in pharmaceuticals of the chinese multiherb remedy xiaochaihu-tang using liquid chromatographic tandem mass spectrometry.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Plants, Medicinal; Saponins; Spectrometry, Mass, Electrospray Ionization | 2004 |
Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Survival; Dose-Response Relationship, Drug; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Membrane Glycoproteins; NF-kappa B; Oleanolic Acid; Proteins; Receptors, Tumor Necrosis Factor; Saponins; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2004 |
Saikosaponin C induces endothelial cells growth, migration and capillary tube formation.
Topics: Antineoplastic Agents, Phytogenic; Capillaries; Cell Movement; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Gene Expression; Humans; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Pathologic; Oleanolic Acid; RNA, Messenger; Saponins; Umbilical Veins; Vascular Endothelial Growth Factor A | 2004 |
[Effect of saikosaponins on epileptic rat electroenciphalogram].
Topics: Animals; Electroencephalography; Epilepsy; Female; Male; Oleanolic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins | 2004 |
Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Calorimetry, Differential Scanning; Cell Membrane; Cholesterol Esters; Fluoresceins; Liposomes; Oleanolic Acid; Rabbits; Saponins; Spectroscopy, Fourier Transform Infrared | 2005 |
Determination of saikosaponins a, c, and d in Bupleurum Chinese DC from different areas by capillary zone electrophoresis.
Topics: Borates; Buffers; Bupleurum; Cyclodextrins; Drugs, Chinese Herbal; Electrophoresis, Capillary; Molecular Structure; Oleanolic Acid; Powders; Reproducibility of Results; Saponins; Stereoisomerism | 2005 |
Therapeutic mechanism of Saikosaponin-d in anti-Thy1 mAb 1-22-3-induced rat model of glomerulonephritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Blood Pressure; Blotting, Western; CD8-Positive T-Lymphocytes; Collagen Type I; Disease Progression; Female; Fluorescent Antibody Technique; Gene Expression Regulation; Glomerulonephritis, Membranoproliferative; Isoantibodies; Kidney Glomerulus; Macrophages; Mesangial Cells; Oleanolic Acid; Proteinuria; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saponins; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2005 |
High performance liquid chromatographic assay of saikosaponins from radix Bupleuri in China.
Topics: Bupleurum; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Indicators and Reagents; Mass Spectrometry; Molecular Sequence Data; Oleanolic Acid; Reference Standards; Reproducibility of Results; Saponins; Spectrophotometry, Ultraviolet | 2005 |
[Cholesteryl hemisuccinate as liposomal membrane stabilizer and its use in the preparation of saikosaponin-D liposomes].
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Calorimetry, Differential Scanning; Cell Membrane; Cholesterol; Cholesterol Esters; Drug Carriers; Fluoresceins; Hemolysis; Liposomes; Oleanolic Acid; Rabbits; Saponins; Spectroscopy, Fourier Transform Infrared | 2005 |
Saikosaponin-d inhibits T cell activation through the modulation of PKCtheta, JNK, and NF-kappaB transcription factor.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; I-kappa B Proteins; Interleukin-2; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lectins, C-Type; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NF-KappaB Inhibitor alpha; Oleanolic Acid; Phosphorylation; Protein Kinase C; Protein Kinase C-theta; Receptors, Transferrin; Saponins; T-Lymphocytes | 2005 |
A novel analytical ELISA-based methodology for pharmacologically active saikosaponins.
Topics: Animals; Antibodies, Monoclonal; Antilymphocyte Serum; Bupleurum; Calibration; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cross Reactions; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Female; Haptens; Hybridomas; Linear Models; Mice; Mice, Inbred BALB C; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Statistics as Topic | 2006 |
[Effect of saikosaponins on epileptic seizure and EEG in pentetrazole-induced chronic kindling rats].
Topics: Animals; Anticonvulsants; Electroencephalography; Epilepsy; Female; Kindling, Neurologic; Male; Oleanolic Acid; Pentylenetetrazole; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins | 2006 |
Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats.
Topics: Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Autoantibodies; Captopril; Diuretics; Drugs, Chinese Herbal; Edema; Furosemide; Humans; Japan; Male; Mice; Nephritis; Oleanolic Acid; Potassium; Random Allocation; Rats; Rats, Wistar; Receptors, Mineralocorticoid; Saponins; Sodium; Spironolactone | 2006 |
[Studies on fingerprints of Bupleurum chinense from Hebei Province with HPLC-UV].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drug Stability; Oleanolic Acid; Plant Roots; Plants, Medicinal; Powders; Quality Control; Reproducibility of Results; Saponins; Spectrophotometry, Ultraviolet | 2006 |
[Effect of saikosaponins on glial fibrillary acidic protein expression in hippocampal astrocytes of pentetrazole-induced chronic kindling rats].
Topics: Animals; Astrocytes; Bupleurum; Depression, Chemical; Female; Glial Fibrillary Acidic Protein; Hippocampus; Kindling, Neurologic; Male; Oleanolic Acid; Pentylenetetrazole; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins | 2006 |
Visual detection of saikosaponins by on-membrane immunoassay and estimation of traditional Chinese medicines containing Bupleuri radix.
Topics: Bupleurum; Chromatography; Immunoassay; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid; Saponins; Software | 2006 |
Antiviral effects of saikosaponins on human coronavirus 229E in vitro.
Topics: Antiviral Agents; Cell Line; Cell Survival; Coronavirus 229E, Human; Humans; Inhibitory Concentration 50; Microbial Sensitivity Tests; Oleanolic Acid; Saponins; Time Factors; Virus Replication | 2006 |
[Saikosaponins inhibit increased glutamate and GABA expressions in the hippocampus of pentetrazole-induced slow kindling rats].
Topics: Animals; Female; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Immunohistochemistry; Kindling, Neurologic; Male; Oleanolic Acid; Pentylenetetrazole; Random Allocation; Rats; Rats, Sprague-Dawley; Saponins | 2006 |
Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice.
Topics: Animals; Benzoates; Bridged-Ring Compounds; Cell Adhesion; Cells, Cultured; Concanavalin A; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Flavanones; Glucosides; Glycyrrhizic Acid; Immunosuppressive Agents; Interferon-gamma; Lymphocyte Activation; Lymphocytes; Matrix Metalloproteinase 2; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Monoterpenes; Nitric Oxide; Oleanolic Acid; Picryl Chloride; RNA, Messenger; Saponins; Spleen | 2006 |
[Effect of saikosaponins-d on cyclooxygenase-2 expression of human hepatocellular carcinoma cell line SMMC-7721].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclooxygenase 2; Humans; Oleanolic Acid; Saponins | 2006 |
Quality control of Chinese medicinal preparations LC/ESI(+)/MS/MS analyses of saikosaponins-a and -c as markers of Bupleuri radix samples.
Topics: Calibration; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Quality Control; Reference Standards; Saponins; Spectrometry, Mass, Electrospray Ionization | 2007 |
Upregulation of isoprenoid pathway genes during enhanced saikosaponin biosynthesis in the hairy roots of Bupleurum falcatum.
Topics: Amino Acid Sequence; Bupleurum; Gene Expression Regulation, Plant; Molecular Sequence Data; Oleanolic Acid; Plant Roots; Saponins; Sequence Alignment; Terpenes; Up-Regulation | 2006 |
Inhibitory effects of saikosaponin-d on CCl4-induced hepatic fibrogenesis in rats.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride; Hyaluronic Acid; Laminin; Liver; Liver Cirrhosis, Experimental; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2007 |
A high-performance liquid chromatographic method for saikosaponin a quantification in rat plasma.
Topics: Animals; Calibration; Chromatography, High Pressure Liquid; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Saponins; Scattering, Radiation; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2007 |
Sho-saiko-to (Xiao-Chai-Hu-Tang) and crude saikosaponins inhibit hepatitis B virus in a stable HBV-producing cell line.
Topics: Cell Line; DNA, Viral; Drugs, Chinese Herbal; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Oleanolic Acid; Plant Extracts; Saponins; Virus Replication | 2007 |
[Effect of saikosaponin-d on rat's glomerular mesangial cell proliferation and extracellular matrix hyperplasia in vitro].
Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cell Survival; Cells, Cultured; Collagen Type IV; Cyclin-Dependent Kinase 4; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Flow Cytometry; Hyperplasia; Immunohistochemistry; Immunosuppressive Agents; Lipopolysaccharides; Male; Mesangial Cells; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Transforming Growth Factor beta1 | 2007 |
Mechanism of saikosaponin-d in the regulation of rat mesangial cell proliferation and synthesis of extracellular matrix proteins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Cells, Cultured; Chronic Disease; Collagen Type IV; Cyclin-Dependent Kinase 4; Down-Regulation; Female; Fibrinogen; Glomerulosclerosis, Focal Segmental; JNK Mitogen-Activated Protein Kinases; Male; Mesangial Cells; Oleanolic Acid; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Rats, Wistar; Saponins; Signal Transduction | 2007 |
Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Collagen Type I; Dimethylnitrosamine; Hepatocytes; Liver Cirrhosis, Experimental; Oleanolic Acid; Oxidative Stress; Rats; Rats, Sprague-Dawley; Saponins; Transforming Growth Factor beta1 | 2007 |
[Aike mixture has good anti-inflammatory and analgesic effects on mice].
Topics: Animals; Chronic Disease; Disease Models, Animal; Drug Combinations; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Phytotherapy; Prostatitis; Saponins | 2007 |
[Effect of saikosaponin alpha on experimental epilepsy in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Epilepsy; Female; Male; Oleanolic Acid; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Saponins; Time Factors | 2007 |
[Separation and refine of Xiaoyao Pill by macroporous adsorption resin].
Topics: Adsorption; Benzoates; Bridged-Ring Compounds; Coumaric Acids; Drug Combinations; Drugs, Chinese Herbal; Glucosides; Glycyrrhetinic Acid; Monoterpenes; Oleanolic Acid; Plants, Medicinal; Resins, Synthetic; Saponins; Tablets; Technology, Pharmaceutical | 2007 |
Effects of Bupleurum scorzoneraefolium, Bupleurum falcatum, and saponins on nephrotoxic serum nephritis in mice.
Topics: Animals; Blood Urea Nitrogen; Bupleurum; Creatinine; Fluorescent Antibody Technique, Direct; Kidney; Mice; Mice, Inbred C57BL; Nephritis; Oleanolic Acid; Phytotherapy; Plant Extracts; Proteinuria; Rabbits; Saponins; Time Factors | 2008 |
[Determination of content of saikoside in Bupleurum Chinense from different sources].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Reproducibility of Results; Saponins | 2008 |
Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Antioxidants; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Curcumin; Glutathione; Lipids; Liver; Liver Diseases; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Superoxide Dismutase | 2008 |
Saireito and saikosaponin D prevent urinary protein excretion via glucocorticoid receptor in adrenalectomized WKY rats with heterologous-phase anti-GBM nephritis.
Topics: Adrenalectomy; Animals; Anti-Glomerular Basement Membrane Disease; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Drug Therapy, Combination; Drugs, Chinese Herbal; Interleukin-10; Interleukin-2; Male; Oleanolic Acid; Rats; Rats, Inbred WKY; Receptors, Glucocorticoid; Saponins | 2008 |
[Experimental study of saikosaponin-D (SSd) on lipid peroxidation of hepatic fibrosis on rat].
Topics: Animals; Aspartate Aminotransferases; Collagen Type IV; Dimethylnitrosamine; Hyaluronic Acid; Laminin; Lipid Peroxidation; Liver Cirrhosis; Malondialdehyde; Oleanolic Acid; Rats; Saponins; Superoxide Dismutase | 2008 |
Localization and dynamic change of saikosaponin in root of Bupleurum chinense.
Topics: Biological Transport; Bupleurum; Oleanolic Acid; Plant Roots; Saponins | 2008 |
Characterization and identification of saikosaponins in crude extracts from three Bupleurum species using LC-ESI-MS.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid; Reference Standards; Saponins; Spectrometry, Mass, Electrospray Ionization | 2008 |
[Inhibitory effects of saikosaponin a on rat hippocampal astrocyte activation in vitro].
Topics: Animals; Animals, Newborn; Astrocytes; Cell Proliferation; Cells, Cultured; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins | 2008 |
Application of centrifugal partition chromatography coupled with evaporative light scattering detection for the isolation of saikosaponins-a and -c from Bupleurum falcatum roots.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Light; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Plant Roots; Reproducibility of Results; Saponins; Scattering, Radiation; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2009 |
Evaluation of traditional Chinese herbal medicine: Chaihu (Bupleuri Radix) by both high-performance liquid chromatographic and high-performance thin-layer chromatographic fingerprint and chemometric analysis.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Drugs, Chinese Herbal; Oleanolic Acid; Pattern Recognition, Automated; Plant Extracts; Quality Control; Saponins; Species Specificity | 2009 |
Fast determination of saikosaponins in Bupleurum by rapid resolution liquid chromatography with evaporative light scattering detection.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Cluster Analysis; Light; Oleanolic Acid; Plant Roots; Reference Standards; Reproducibility of Results; Saponins; Scattering, Radiation; Solvents; Spectrophotometry, Ultraviolet | 2009 |
Mechanistic study of saikosaponin-d (Ssd) on suppression of murine T lymphocyte activation.
Topics: Animals; Blotting, Western; Cell Proliferation; Cytokines; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; NFATC Transcription Factors; Oleanolic Acid; Saponins; Signal Transduction; T-Lymphocytes; Transcription Factor AP-1 | 2009 |
Saikosaponin a inhibits the proliferation and activation of T cells through cell cycle arrest and induction of apoptosis.
Topics: Animals; Apoptosis; Autoimmune Diseases; Bupleurum; Cell Cycle; Cell Proliferation; Cyclin D3; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cytochromes c; Dose-Response Relationship, Drug; Down-Regulation; Female; Immunosuppression Therapy; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Oleanolic Acid; Saponins; T-Lymphocytes; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
[Estrogen-like effects of saikosaponin-d in mice].
Topics: Animals; Estrogens; Female; Mice; Mice, Inbred BALB C; Oleanolic Acid; Ovariectomy; Random Allocation; Saponins | 2009 |
[Angiogenesis inhibitory effect of saikosaponin-d on chicken embryo].
Topics: Angiogenesis Inhibitors; Animals; Chick Embryo; Chorioallantoic Membrane; Neovascularization, Physiologic; Oleanolic Acid; Saponins | 2009 |
Estrogen-like activities of saikosaponin-d in vitro: a pilot study.
Topics: Animals; Blotting, Western; Cell Cycle; Cell Proliferation; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Gene Expression Regulation; HeLa Cells; Humans; Luciferases; Oleanolic Acid; Pilot Projects; Response Elements; RNA, Messenger; Saponins; Transfection | 2010 |
Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Curcuma; Curcumin; Cytokines; Dietary Supplements; Drug Therapy, Combination; Fibrosis; Hydroxyproline; Inflammation; Liver; Male; NF-kappa B; Oleanolic Acid; Phytotherapy; Plant Extracts; Plant Roots; Random Allocation; Rats; Rats, Sprague-Dawley; Rhizome; Saponins; Transforming Growth Factor beta1 | 2010 |
Optimization of supercritical fluid extraction of saikosaponins from Bupleurum falcatum with orthogonal array design.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Equipment Design; Ethanol; Oleanolic Acid; Plant Roots; Pressure; Saponins; Temperature; Time Factors | 2010 |
[Study on the optimal extraction process of chaihushugan powder].
Topics: Benzoates; Bridged-Ring Compounds; Bupleurum; Chromatography, High Pressure Liquid; Coumaric Acids; Drug Combinations; Drugs, Chinese Herbal; Ethanol; Glucosides; Hesperidin; Hot Temperature; Monoterpenes; Oleanolic Acid; Plants, Medicinal; Powders; Quality Control; Saponins; Solubility; Technology, Pharmaceutical; Time Factors | 2009 |
[Differences of saikosaponin contents in Bupleurum chinense from habitats in Dongling Mountain & Wuling Mountain of Beijing].
Topics: Bupleurum; China; Chromatography, High Pressure Liquid; DNA Primers; Ecosystem; Oleanolic Acid; Saponins | 2009 |
[Therapeutic effects and mechanism of saikosaponin-d in mice with bleomycin-induced pulmonary fibrosis].
Topics: Animals; Bleomycin; Female; Lung; Male; Mice; Mice, Inbred Strains; Oleanolic Acid; Phytotherapy; Pulmonary Fibrosis; Saponins | 2010 |
Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Oleanolic Acid; Plant Extracts; Saponins | 2010 |
Inhibition of human renin activity by saponins.
Topics: Fruit; Glycine max; Glycyrrhetinic Acid; Glycyrrhizic Acid; Humans; Oleanolic Acid; Renin; Saponins | 2010 |
Application of accelerated solvent extraction to the investigation of saikosaponins from the roots of Bupleurum falcatum.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Oleanolic Acid; Plant Roots; Saponins; Solvents; Spectrophotometry, Ultraviolet; Temperature | 2010 |
Identification and determination of the saikosaponins in Radix bupleuri by accelerated solvent extraction combined with rapid-resolution LC-MS.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ethanol; Mass Spectrometry; Medicine, Chinese Traditional; Molecular Conformation; Oleanolic Acid; Plant Extracts; Saponins; Stereoisomerism | 2010 |
An LC-MS method for simultaneous determination of nine ginsenosides in rat plasma and its application in pharmacokinetic study.
Topics: Animals; Area Under Curve; Chromatography, Liquid; Drug Stability; Drugs, Chinese Herbal; Ginsenosides; Linear Models; Male; Oleanolic Acid; Rats; Rats, Wistar; Reproducibility of Results; Saponins; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization | 2011 |
[Study on hepatotoxicity on rats caused by crude extracts of total saikosaponins and correlation with oxidative damage mechanism].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Female; Humans; Liver; Male; Malondialdehyde; Oleanolic Acid; Oxidative Stress; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Saponins; Superoxide Dismutase | 2010 |
[Breeding of new varieties "zhongchai no. 2" and "zhongchai no. 3" of Bupleurum chinense].
Topics: Breeding; Bupleurum; Oleanolic Acid; Plant Extracts; Saponins | 2010 |
Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines.
Topics: Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Caspase 2; Caspase 8; Caspase 9; Cell Line, Tumor; Colonic Neoplasms; Cyclosporine; Flow Cytometry; Humans; Inhibitor of Apoptosis Proteins; Mitochondria; Oleanolic Acid; Oligopeptides; Poly(ADP-ribose) Polymerases; RNA, Small Interfering; Saponins; Signal Transduction; Survivin | 2011 |
["Dose-toxicity" relationship study on rat's chronic hepatoxicity of refined products of saikosaponin by alcohol elution].
Topics: Animals; Bupleurum; Dose-Response Relationship, Drug; Ethanol; Female; Humans; Liver; Male; Oleanolic Acid; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Saponins | 2010 |
Reactive oxygen species-mediated apoptosis contributes to chemosensitization effect of saikosaponins on cisplatin-induced cytotoxicity in cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Separation; Cisplatin; Flow Cytometry; Humans; Neoplasms; Oleanolic Acid; Reactive Oxygen Species; Saponins | 2010 |
Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry.
Topics: Administration, Oral; Animals; Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Flavanones; Flavonoids; Glucosides; Glucuronides; Medicine, Chinese Traditional; Oleanolic Acid; Rats; Saponins; Scutellaria baicalensis; Spectrometry, Mass, Electrospray Ionization | 2010 |
[Study on dynamic accumulation of index components from Bupleurum chinense in various collecting periods].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Oils, Volatile; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Seasons; Spectrophotometry, Ultraviolet | 2010 |
Glaucasides A-C, three saikosaponins from Atriplex glauca L. var. ifiniensis (Caball) Maire.
Topics: Atriplex; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Fast Atom Bombardment | 2011 |
Analysis of saikosaponins in Bupleuri Radix and Caihu-shugan-san using reversed-phase HPLC with pulsed amperometric detection.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drugs, Chinese Herbal; Oleanolic Acid; Saponins | 2011 |
Fast and sensitive LC-DAD-ESI/MS method for analysis of saikosaponins c, a, and d from the roots of Bupleurum Falcatum (Sandaochaihu).
Topics: Bupleurum; Chromatography, Liquid; Limit of Detection; Medicine, Chinese Traditional; Molecular Structure; Oleanolic Acid; Plant Roots; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2011 |
Inactivation of cystein-aspartic acid protease (caspase)-1 by saikosaponin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Caspase 1; Caspase Inhibitors; Cell Line; Cell Nucleus; Cytokines; Enzyme Activation; Female; Gene Expression Regulation; Genes, Reporter; Humans; I-kappa B Proteins; MAP Kinase Signaling System; Mast Cells; Mice; Mice, Inbred BALB C; NF-kappa B; Oleanolic Acid; Protein Transport; Rhinitis; RNA, Messenger; Saponins; Specific Pathogen-Free Organisms | 2011 |
[Quality inspection of commercial Bupluri Radix samples in Guangzhou: an ELISA for determining saikosaponin A content using anti-saikosaponin A monoclonal antibody].
Topics: Antibodies, Monoclonal; Bupleurum; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Oleanolic Acid; Quality Control; Saponins | 2011 |
Large-scale production of saikosaponins through root culturing of Bupleurum falcatum L. using modified airlift reactors.
Topics: Bioreactors; Bupleurum; Culture Media; Oleanolic Acid; Plant Roots; Saponins; Tissue Culture Techniques | 2012 |
Analysis of saikosaponins in rat plasma by anionic adducts-based liquid chromatography tandem mass spectrometry method.
Topics: Animals; Anions; Chromatography, Liquid; Digoxin; Drug Stability; Drugs, Chinese Herbal; Linear Models; Liquid-Liquid Extraction; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Tandem Mass Spectrometry | 2012 |
Oleanene glycosides of the aerial parts and seeds of Bupleurum falcatum and the aerial parts of Bupleurum rotundifolium, and their evaluation as anti-hepatitis agents.
Topics: Animals; Bupleurum; Cells, Cultured; Hepatocytes; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Oleanolic Acid; Plant Components, Aerial; Protective Agents; Rabbits; Rats; Rats, Wistar; Saponins; Seeds | 2011 |
Transcriptome analysis of Bupleurum chinense focusing on genes involved in the biosynthesis of saikosaponins.
Topics: Bupleurum; Cytochrome P-450 Enzyme System; DNA, Plant; Expressed Sequence Tags; Gene Library; Genes, Plant; Glucuronosyltransferase; Molecular Sequence Annotation; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Sequence Analysis, DNA; Transcriptome | 2011 |
Interaction of the main components from the traditional Chinese drug pair Chaihu-Shaoyao based on rat intestinal absorption.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bridged-Ring Compounds; Bupleurum; Drugs, Chinese Herbal; Glucosides; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Medicine, Chinese Traditional; Molecular Structure; Monoterpenes; Oleanolic Acid; Paeonia; Rats; Rats, Sprague-Dawley; Saponins | 2011 |
Species discrimination of Radix Bupleuri through the simultaneous determination of ten saikosaponins by high performance liquid chromatography with evaporative light scattering detection and electrospray ionization mass spectrometry.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Cluster Analysis; Drugs, Chinese Herbal; Light; Limit of Detection; Linear Models; Oleanolic Acid; Plant Roots; Reproducibility of Results; Saponins; Scattering, Radiation; Species Specificity; Spectrometry, Mass, Electrospray Ionization | 2011 |
Chemopreventive effect of saikosaponin-d on diethylinitrosamine-induced hepatocarcinogenesis: involvement of CCAAT/enhancer binding protein β and cyclooxygenase-2.
Topics: Animals; Bupleurum; CCAAT-Enhancer-Binding Protein-beta; Chemoprevention; Cyclooxygenase 2; Diethylnitrosamine; Immunohistochemistry; Liver Neoplasms, Experimental; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins | 2012 |
[Research on mechanism of energy metabolism disorders of rat's hepatoxicity induced by saikosaponins].
Topics: Animals; Antimetabolites; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Electron Transport; Energy Metabolism; Female; Liver; Male; Mitochondria, Liver; Oleanolic Acid; Organ Size; Rats; Saponins | 2011 |
Study on the noncovalent interactions of saikosaponins and cytochrome c by electrospray ionization mass spectrometry.
Topics: Animals; Bupleurum; Cytochromes c; Horses; Oleanolic Acid; Oligosaccharides; Protein Binding; Saponins; Spectrometry, Mass, Electrospray Ionization; Triterpenes | 2012 |
[Effect of Saikosaponins-d on reversing malignant phenotype of HepG2 cells in vitro].
Topics: Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Liver Neoplasms; Oleanolic Acid; RNA, Messenger; Saponins | 2011 |
[Effects of interferon-alpha combined with saikosaponin on serum T lymphocyte subgroups and hepatic cytokines in mice with immune hepatic injury].
Topics: Animals; Cytokines; Hepatitis, Autoimmune; Interferon-alpha; Liver; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Saponins; T-Lymphocyte Subsets | 2012 |
[Optimization of the ultrasound assisted extraction of saikosaponins from Bupleurum falcatum using response surface methodology].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Ethanol; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Solvents; Temperature; Time Factors; Ultrasonics | 2011 |
Metabolic fingerprinting by 1HNMR for discrimination of the two species used as Radix Bupleuri.
Topics: Arginine; Bupleurum; China; Citric Acid; Magnetic Resonance Spectroscopy; Medicine, Chinese Traditional; Metabolomics; Multivariate Analysis; Oils, Volatile; Oleanolic Acid; Phylogeography; Principal Component Analysis; Saponins; Sucrose | 2012 |
Saikosaponin-d inhibits β-conglycinin induced activation of rat basophilic leukemia-2H3 cells.
Topics: Animals; Anti-Allergic Agents; Antigens, Plant; beta-N-Acetylhexosaminidases; Calcium Signaling; Cell Degranulation; Cell Line, Tumor; Food Hypersensitivity; Globulins; Glycine max; Humans; Immunoglobulin E; Leukemia, Basophilic, Acute; Mast Cells; Medicine, Chinese Traditional; Oleanolic Acid; Phosphorylation; Rats; Reactive Oxygen Species; Saponins; Seed Storage Proteins; Signal Transduction; Soybean Proteins; Tyrosine | 2012 |
Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupleurum; Capillary Permeability; Cell Line; Cyclooxygenase 2; Cytokines; Immunosuppression Therapy; Inflammation Mediators; Lipopolysaccharides; Macrophages; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Saponins; Signal Transduction; Stereoisomerism; Transcriptional Activation | 2012 |
Solubilization of saikosaponin a by ginsenoside Ro biosurfactant in aqueous solution: mesoscopic simulation.
Topics: Computer Simulation; Ginsenosides; Humans; Medicine, Chinese Traditional; Micelles; Microscopy, Electron, Transmission; Models, Chemical; Oleanolic Acid; Panax; Saponins; Scattering, Small Angle; Solubility; Solutions; Surface-Active Agents; Thermodynamics; Water; X-Ray Diffraction | 2012 |
Effect of saikosaponin A on maintenance of intravenous morphine self-administration.
Topics: Animals; Conditioning, Psychological; Drug Interactions; Infusions, Intravenous; Male; Morphine; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Saponins; Self Administration | 2012 |
[Impact of saikosaponin on absorption and transport of paeoniflorin in Caco-2 cell model].
Topics: Absorption; Benzoates; Biological Transport; Bridged-Ring Compounds; Caco-2 Cells; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Glucosides; Humans; Monoterpenes; Oleanolic Acid; Saponins | 2012 |
Saikosaponin a mediates the anticonvulsant properties in the HNC models of AE and SE by inhibiting NMDA receptor current and persistent sodium current.
Topics: Animals; Anticonvulsants; Cells, Cultured; Electrophysiology; Epilepsy; Hippocampus; Neurons; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Saponins; Sodium; Status Epilepticus | 2012 |
Metabolism of saikosaponin a in rats: diverse oxidations on the aglycone moiety in liver and intestine in addition to hydrolysis of glycosidic bonds.
Topics: Administration, Oral; Animals; Bile; Biotransformation; Chromatography, Liquid; Drugs, Chinese Herbal; Feces; Hydrolysis; Injections, Intravenous; Intestines; Liver; Male; Molecular Structure; Oleanolic Acid; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Saponins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2013 |
Effects of saikosaponin-d on syndecan-2, matrix metalloproteinases and tissue inhibitor of metalloproteinases-2 in rats with hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Drugs, Chinese Herbal; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Matrix Metalloproteinases; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Syndecan-2; Tissue Inhibitor of Metalloproteinase-2 | 2012 |
[Structure of secondary saikosaponins in saiko decoction].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Mass Spectrometry; Molecular Structure; Oleanolic Acid; Saponins | 2012 |
Osteoclast-inhibiting saikosaponin derivatives from Bupleurum chinense.
Topics: Animals; Bupleurum; Cells, Cultured; Drug Evaluation, Preclinical; Mice; Mice, Inbred C57BL; Molecular Structure; Oleanolic Acid; Osteoclasts; Plant Extracts; Plants, Medicinal; Saponins | 2013 |
Multiscale study on the interaction mechanism between ginsenoside biosurfactant and saikosaponin a.
Topics: Computer Simulation; Ginsenosides; Light; Micelles; Microscopy, Electron, Transmission; Oleanolic Acid; Saponins; Scattering, Radiation; Surface-Active Agents; Unilamellar Liposomes | 2013 |
Neuroprotective effects of total saikosaponins of Bupleurum yinchowense on corticosterone-induced apoptosis in PC12 cells.
Topics: Animals; Apoptosis; Bupleurum; Calcium; Caspase 3; Cell Survival; Corticosterone; Endoplasmic Reticulum Stress; L-Lactate Dehydrogenase; Membrane Potential, Mitochondrial; Mitochondria; Neuroprotective Agents; Oleanolic Acid; PC12 Cells; Rats; Saponins; Sincalide | 2013 |
Saikosaponin-d, a novel SERCA inhibitor, induces autophagic cell death in apoptosis-defective cells.
Topics: Adenylate Kinase; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein 7; Beclin-1; Binding Sites; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Tumor; Class III Phosphatidylinositol 3-Kinases; Membrane Proteins; Mice; Models, Molecular; Oleanolic Acid; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin-Activating Enzymes; Unfolded Protein Response | 2013 |
Saikosaponin A of Bupleurum chinense (Chaihu) elevates bone morphogenetic protein 4 (BMP-4) during hepatic stellate cell activation.
Topics: Actins; Animals; bcl-2-Associated X Protein; Bone Morphogenetic Protein 4; Bupleurum; Cattle; Cell Line; Cell Proliferation; Cells, Cultured; Drugs, Chinese Herbal; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Oleanolic Acid; Phytotherapy; RNA, Messenger; Saponins | 2013 |
Saikosaponin D disrupts platelet-derived growth factor-β receptor/p38 pathway leading to mitochondrial apoptosis in human LO2 hepatocyte cells: a potential mechanism of hepatotoxicity.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Hepatocytes; Humans; Mitochondria; Molecular Structure; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Receptors, Platelet-Derived Growth Factor; Saponins; Structure-Activity Relationship | 2013 |
[Study on preparation and optimization of saikoside liposomes].
Topics: Bupleurum; Cholesterol; Citric Acid; Drug Carriers; Liposomes; Oleanolic Acid; Particle Size; Phospholipids; Plant Roots; Resins, Synthetic; Saponins | 2013 |
Saikosaponin a and saikosaponin d inhibit proliferation and migratory activity of rat HSC-T6 cells.
Topics: Animals; Becaplermin; Bupleurum; Cell Movement; Cell Proliferation; Drugs, Chinese Herbal; Growth Inhibitors; Hepatic Stellate Cells; MAP Kinase Signaling System; Oleanolic Acid; Proto-Oncogene Proteins c-sis; Rats; Receptors, Transforming Growth Factor beta; Saponins; Transforming Growth Factor beta1 | 2013 |
Effects of saikosaponin A on cocaine self-administration in rats.
Topics: Animals; Bicuculline; Cocaine; GABA-A Receptor Antagonists; GABA-B Receptor Antagonists; Male; Morpholines; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Saponins; Self Administration | 2013 |
Saikosaponin-d increases the radiosensitivity of smmc-7721 hepatocellular carcinoma cells by adjusting the g0/g1 and g2/m checkpoints of the cell cycle.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Humans; Liver Neoplasms; Oleanolic Acid; Proto-Oncogene Proteins c-bcl-2; Radiation-Sensitizing Agents; RNA, Messenger; Saponins; Tumor Suppressor Protein p53; X-Rays | 2013 |
[Expression analysis of glycosyltransferase BcUGT1 from Bupleurum chinense DC. and its expression in E. coli and the target protein purification].
Topics: Amino Acid Sequence; Base Sequence; Bupleurum; Cloning, Molecular; DNA, Complementary; DNA, Plant; Escherichia coli; Genetic Vectors; Glycosyltransferases; Oleanolic Acid; Open Reading Frames; Phylogeny; Plants, Medicinal; Protein Structure, Secondary; Recombinant Fusion Proteins; Saponins | 2013 |
Effect of corchorusin-D, a saikosaponin like compound, on B16F10 melanoma cells (in vitro and in vivo).
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 9; Corchorus; Glycosides; Humans; Melanoma; Membrane Potential, Mitochondrial; Mice; Mitochondria; Molecular Structure; Oleanolic Acid; Saponins; Skin Neoplasms; Triterpenes | 2013 |
Saikosaponin-D enhances radiosensitivity of hepatoma cells under hypoxic conditions by inhibiting hypoxia-inducible factor-1α.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Carcinoma, Hepatocellular; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Radiation Tolerance; Saponins; Tumor Stem Cell Assay; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2014 |
Saikosaponin C inhibits lipopolysaccharide-induced apoptosis by suppressing caspase-3 activation and subsequent degradation of focal adhesion kinase in human umbilical vein endothelial cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bupleurum; Caspase 3; Focal Adhesion Protein-Tyrosine Kinases; Human Umbilical Vein Endothelial Cells; Humans; Lipopolysaccharides; Oleanolic Acid; Saponins | 2014 |
Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway.
Topics: Analysis of Variance; Animals; Annexin A5; Anti-Inflammatory Agents; Apoptosis; Calcium; Cell Survival; Corticosterone; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oleanolic Acid; PC12 Cells; Propidium; Rats; Receptors, Glucocorticoid; Saponins; Signal Transduction | 2014 |
Effect of saikosaponins and extracts of vinegar-baked Bupleuri Radix on the activity of β-glucuronidase.
Topics: 1-Butanol; Acetic Acid; Bupleurum; Drugs, Chinese Herbal; Glucuronates; Glucuronidase; Liver; Nitrophenols; Oleanolic Acid; Saponins | 2014 |
Saikosaponin‑d inhibits proliferation of DU145 human prostate cancer cells by inducing apoptosis and arresting the cell cycle at G0/G1 phase.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cytochromes c; G1 Phase Cell Cycle Checkpoints; Humans; Male; Membrane Potential, Mitochondrial; Oleanolic Acid; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Saponins; Tumor Suppressor Protein p53; Up-Regulation | 2014 |
Modulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro.
Topics: Acetic Acid; Animals; Bupleurum; Cytochrome P-450 Enzyme System; Drugs, Chinese Herbal; Herb-Drug Interactions; Isoenzymes; Male; Mice; Microsomes, Liver; Oleanolic Acid; Plant Extracts; Saponins; Time Factors | 2014 |
Cell type-specific qualitative and quantitative analysis of saikosaponins in three Bupleurum species using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry.
Topics: Bupleurum; Chromatography, High Pressure Liquid; Lasers; Mass Spectrometry; Microdissection; Oleanolic Acid; Plant Structures; Saponins | 2014 |
Effects of SSd combined with radiation on inhibiting SMMC-7721 hepatoma cell growth.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Humans; In Vitro Techniques; Liver Neoplasms; Microscopy, Electron, Transmission; Oleanolic Acid; Radiation-Sensitizing Agents; Saponins; Tetrazolium Salts; Thiazoles | 2014 |
Attenuation of neuropathic pain by saikosaponin a in a rat model of chronic constriction injury.
Topics: Animals; Chronic Disease; Constriction; Disease Models, Animal; Male; Neuralgia; NF-kappa B; Oleanolic Acid; Rats, Sprague-Dawley; Saponins; Sciatic Nerve; Spinal Cord; Tumor Necrosis Factor-alpha | 2014 |
Saikosaponin-D attenuates heat stress-induced oxidative damage in LLC-PK1 cells by increasing the expression of anti-oxidant enzymes and HSP72.
Topics: Animals; Bupleurum; Catalase; Dose-Response Relationship, Drug; Glutathione Peroxidase; Heat-Shock Response; Hot Temperature; HSP72 Heat-Shock Proteins; LLC-PK1 Cells; Malondialdehyde; Oleanolic Acid; Oxidative Stress; Plant Extracts; Reactive Oxygen Species; Saponins; Superoxide Dismutase; Swine | 2014 |
Saikosaponin‑d suppresses the expression of cyclooxygenase‑2 through the phospho‑signal transducer and activator of transcription 3/hypoxia‑inducible factor‑1α pathway in hepatocellular carcinoma cells.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Proliferation; Cell Shape; Cyclooxygenase 2; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Oleanolic Acid; Phosphorylation; Protein Processing, Post-Translational; Saponins; STAT3 Transcription Factor | 2014 |
Hepatoprotective saikosaponin homologs from Comastoma pedunculatum.
Topics: Cell Line, Tumor; Cytostatic Agents; Gentianaceae; Humans; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Protective Agents; Saponins; Triterpenes | 2014 |
Saikosaponin d protects against acetaminophen-induced hepatotoxicity by inhibiting NF-κB and STAT3 signaling.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antipyretics; Bupleurum; Chemical and Drug Induced Liver Injury; Cytokines; Down-Regulation; Drugs, Chinese Herbal; Humans; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Oxidative Stress; Plants, Medicinal; PPAR alpha; RNA, Messenger; Saponins; Signal Transduction; STAT3 Transcription Factor | 2014 |
Anthelmintic activity of saikosaponins a and d from radix bupleuri against Dactylogyrus spp. infecting goldfish.
Topics: Animals; Anthelmintics; Bupleurum; Fish Diseases; Goldfish; Helminthiasis, Animal; Molecular Structure; Oleanolic Acid; Plant Roots; Platyhelminths; Saponins | 2014 |
Saikosaponin-d inhibits proliferation of human undifferentiated thyroid carcinoma cells through induction of apoptosis and cell cycle arrest.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Humans; Male; Mice; Mice, Nude; Oleanolic Acid; Saponins; Thyroid Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Shu‑Yu capsule, a Traditional Chinese Medicine formulation, attenuates premenstrual syndrome depression induced by chronic stress constraint.
Topics: Animals; Body Mass Index; Depression; Drugs, Chinese Herbal; Female; Fluoxetine; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Medicine, Chinese Traditional; Oleanolic Acid; Premenstrual Syndrome; Rats; Rats, Wistar; Saponins | 2014 |
New triterpenoid saponins from the aerial parts of Comastomapedunculatum.
Topics: Araliaceae; Drugs, Chinese Herbal; Molecular Structure; Nitric Oxide; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Components, Aerial; Saponins | 2015 |
Pharmacological experimental study of the anti-depressant effect of total saikosaponins.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Hindlimb Suspension; Humans; Male; Mice; Motor Activity; Oleanolic Acid; Saponins | 2014 |
Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.
Topics: Animals; Antiviral Agents; Bupleurum; Cell Line; Hepacivirus; Hepatitis C; Hepatocytes; Humans; Liver Transplantation; Male; Oleanolic Acid; Plant Extracts; Rats; Rats, Sprague-Dawley; Saponins; Virion; Virus Internalization; Virus Replication | 2015 |
Saikosaponin D isolated from Bupleurum falcatum inhibits selectin-mediated cell adhesion.
Topics: Bupleurum; Cell Adhesion; Cell Adhesion Molecules; Cell Line; Cell Survival; Endothelial Cells; Gene Expression; Humans; Immunophenotyping; Molecular Structure; Monocytes; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Selectins; Tumor Necrosis Factor-alpha | 2014 |
Separation and identification of multiple constituents in Xiao Chai Hu Decoction (Sho-saiko-to) by bioactivity-guided fractionation combined with LC-ESI-QTOFMS/MS.
Topics: Bupleurum; Catechols; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Fatty Alcohols; Flavonoids; Ginsenosides; Oleanolic Acid; Plant Extracts; Polysaccharides; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-κB and MAPK pathways.
Topics: Animals; Bone Marrow Cells; Bupleurum; Cell Differentiation; Cell Line; Humans; Immunosuppressive Agents; Medicine, Chinese Traditional; Mice; Monocytes; NF-kappa B; Oleanolic Acid; Osteoclasts; Osteoporosis; p38 Mitogen-Activated Protein Kinases; RANK Ligand; Saponins; Signal Transduction | 2015 |
Saikosaponin a, an active compound of Radix Bupleuri, attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-κB signaling pathways.
Topics: 3T3-L1 Cells; Animals; Anti-Inflammatory Agents; Cytokines; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Inflammation; Inflammation Mediators; Mice; NF-kappa B; Nitric Oxide; Oleanolic Acid; Saponins; Signal Transduction | 2015 |
Chemical and biological comparison of raw and vinegar-baked Radix Bupleuri.
Topics: Acetic Acid; Animals; Bupleurum; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Female; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Oleanolic Acid; Plant Extracts; Saponins | 2015 |
[Effect of combined application of zinc, boron and molybdenum on yield and saikosaponin a, saikosaponin d contents of Bupleurum chinense].
Topics: Boron; Bupleurum; Fertilizers; Molybdenum; Oleanolic Acid; Plant Roots; Saponins; Trace Elements; Zinc | 2014 |
Formulations, hemolytic and pharmacokinetic studies on saikosaponin a and saikosaponin d compound liposomes.
Topics: Administration, Intravenous; Animals; Biological Availability; Chemistry, Pharmaceutical; Half-Life; Hemolysis; Hydrophobic and Hydrophilic Interactions; Liposomes; Molecular Structure; Oleanolic Acid; Particle Size; Rabbits; Saponins | 2015 |
Saikosaponin-D reduces cisplatin-induced nephrotoxicity by repressing ROS-mediated activation of MAPK and NF-κB signalling pathways.
Topics: Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cell Line; Cell Survival; Cisplatin; Cytokines; Humans; Kidney Diseases; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oleanolic Acid; Reactive Oxygen Species; RNA, Messenger; Saponins; Signal Transduction | 2015 |
Recognition and identification of active components from Radix Bupleuri using human neuroblastoma SH-SY5Y cells.
Topics: Cell Line, Tumor; Cell Membrane; Chromatography, Liquid; Drug Discovery; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Humans; Medicine, Chinese Traditional; Neuroblastoma; Oleanolic Acid; Plants, Medicinal; Psychotropic Drugs; Reproducibility of Results; Saponins | 2016 |
Ethanol extract of Bupleurum falcatum and saikosaponins inhibit neuroinflammation via inhibition of NF-κB.
Topics: Animals; Anti-Inflammatory Agents; Bupleurum; Cell Survival; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Ethanol; Inflammation; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Plant Roots; Saponins | 2015 |
Cytotoxic triterpenoid glycosides (saikosaponins) from the roots of Bupleurum chinense.
Topics: Bupleurum; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Oleanolic Acid; Plant Extracts; Plant Roots; Saponins; Stereoisomerism; Structure-Activity Relationship | 2015 |
Inhibitory Activity of Yokukansankachimpihange against Nerve Growth Factor-Induced Neurite Growth in Cultured Rat Dorsal Root Ganglion Neurons.
Topics: Alkaloids; Animals; Bupleurum; Cell Death; Cells, Cultured; Drugs, Chinese Herbal; Ganglia, Spinal; Indole Alkaloids; Male; Nerve Growth Factor; Neurites; Oleanolic Acid; Oxindoles; Plant Extracts; Rats, Sprague-Dawley; Saponins; Uncaria | 2015 |
Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts.
Topics: Anti-Inflammatory Agents; Blotting, Western; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Membrane Microdomains; Oleanolic Acid; Oxidative Stress; Protein Transport; Reactive Oxygen Species; RNA, Small Interfering; Saponins; Signal Transduction; Toll-Like Receptor 4; Transfection | 2015 |
Saikosaponin A inhibits influenza A virus replication and lung immunopathology.
Topics: Animals; Antiviral Agents; Cell Line; Disease Models, Animal; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunoblotting; Influenza A virus; Influenza, Human; Lung; Mice; Mice, Inbred C57BL; Oleanolic Acid; Orthomyxoviridae Infections; Respiratory Tract Infections; Saponins; Virus Replication | 2015 |
Activation of Fas death receptor pathway and Bid in hepatocytes is involved in saikosaponin D induction of hepatotoxicity.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Bupleurum; Caspase 8; Cell Line; Chemical and Drug Induced Liver Injury; fas Receptor; Hepatocytes; Humans; Male; MAP Kinase Signaling System; Mice; Mitochondria; Oleanolic Acid; Saponins; Signal Transduction | 2016 |
Anti-melanoma activity of Bupleurum chinense, Bupleurum kaoi and nanoparticle formulation of their major bioactive compound saikosaponin-d.
Topics: Apoptosis Regulatory Proteins; Bupleurum; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Drugs, Chinese Herbal; Humans; MAP Kinase Signaling System; Melanoma; Membrane Potential, Mitochondrial; Nanoparticles; Oleanolic Acid; Particle Size; Plant Roots; Saponins; Solubility | 2016 |
HepG2 cells biospecific extraction and HPLC-ESI-MS analysis for screening potential antiatherosclerotic active components in Bupeuri radix.
Topics: Atherosclerosis; Cell Line, Tumor; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hep G2 Cells; Humans; Medicine, Chinese Traditional; Oleanolic Acid; Plant Roots; Saponins; Spectrometry, Mass, Electrospray Ionization | 2016 |
Development of an Enzyme-Linked Immunosorbent Assay and Immunoaffinity Column Chromatography for Saikosaponin d Using an Anti-Saikosaponin d Monoclonal Antibody.
Topics: Animals; Antibodies, Monoclonal; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred BALB C; Oleanolic Acid; Saponins; Sensitivity and Specificity | 2016 |
Binding between Saikosaponin C and Human Serum Albumin by Fluorescence Spectroscopy and Molecular Docking.
Topics: Binding Sites; Circular Dichroism; Energy Transfer; Humans; Hydrogen Bonding; Models, Molecular; Molecular Docking Simulation; Oleanolic Acid; Protein Binding; Protein Conformation; Saponins; Serum Albumin; Spectrometry, Fluorescence | 2016 |
Saikosaponin-a Attenuates Oxidized LDL Uptake and Prompts Cholesterol Efflux in THP-1 Cells.
Topics: Atherosclerosis; ATP Binding Cassette Transporter 1; CD36 Antigens; Cell Culture Techniques; Cholesterol; Cytokines; Humans; Lipoproteins; Lipoproteins, LDL; Macrophages; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; PPAR gamma; Receptors, Lipoprotein; Saponins | 2016 |
Saikosaponin-D Reduces H
Topics: Animals; Antioxidants; Apoptosis; Bupleurum; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oleanolic Acid; Oxidative Stress; PC12 Cells; Rats; Reactive Oxygen Species; Saponins | 2016 |
Ultrasensitive Time-Resolved Fluoroimmunoassay for Saikosaponin a in Chaihu (Bupleuri Radix).
Topics: Apiaceae; Drugs, Chinese Herbal; Fluoroimmunoassay; Oleanolic Acid; Reproducibility of Results; Saponins | 2016 |
UFLC-MS/MS determination and pharmacokinetic studies of six Saikosaponins in rat plasma after oral administration of Bupleurum Dropping Pills.
Topics: Administration, Oral; Animals; Bupleurum; Limit of Detection; Oleanolic Acid; Plant Extracts; Rats; Reference Standards; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2016 |
In vitro metabolism study of saikosaponin d and its derivatives in rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Hydroxylation; Microsomes, Liver; Oleanolic Acid; Rats; Saponins | 2017 |
Reducing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on alcohol self-administration in rats: Possible involvement of the GABAB receptor.
Topics: Allosteric Regulation; Animals; Bupleurum; Cyclopentanes; Ethanol; GABA-B Receptor Antagonists; Male; Morpholines; Motivation; Motor Activity; Oleanolic Acid; Pyrimidines; Rats; Receptors, GABA-B; Reinforcement, Psychology; Saponins; Self Administration | 2016 |
Saikosaponin A, an active glycoside from Radix bupleuri, reverses P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cells and HepG2/ADM cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Resistance, Multiple; Hep G2 Cells; Humans; Oleanolic Acid; Saponins | 2017 |
Saikosaponin-d: A potential chemotherapeutics in castration resistant prostate cancer by suppressing cancer metastases and cancer stem cell phenotypes.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Feasibility Studies; Humans; Male; Neoplasm Invasiveness; Neoplastic Stem Cells; Oleanolic Acid; Prostatic Neoplasms, Castration-Resistant; Saponins | 2016 |
Anti-Inflammation Effects and Potential Mechanism of Saikosaponins by Regulating Nicotinate and Nicotinamide Metabolism and Arachidonic Acid Metabolism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Biomarkers; Chromatography, High Pressure Liquid; Mass Spectrometry; Metabolism; Metabolomics; Mice; Niacin; Niacinamide; Oleanolic Acid; Saponins | 2016 |
Saikosaponin a functions as anti-epileptic effect in pentylenetetrazol induced rats through inhibiting mTOR signaling pathway.
Topics: Animals; Apoptosis; Down-Regulation; Epilepsy; Hippocampus; Interleukin-1beta; Leucine; Male; Neurons; Neuroprotective Agents; Oleanolic Acid; Pentylenetetrazole; Phosphorylation; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Saponins; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha | 2016 |
Saikosaponin a inhibits LPS-induced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophages.
Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter 1; Cell Membrane; Cell Survival; Cholesterol; Cytokines; Endotoxemia; Female; Inflammation; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver X Receptors; Macrophages; Male; Membrane Microdomains; Mice; Mice, Inbred BALB C; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction; Toll-Like Receptor 4; Treatment Outcome | 2016 |
Saikosaponin d induces cell death through caspase-3-dependent, caspase-3-independent and mitochondrial pathways in mammalian hepatic stellate cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Bupleurum; Caspase 3; Caspase 9; Caspase Inhibitors; Cell Line; Cell Proliferation; Drugs, Chinese Herbal; Hepatic Stellate Cells; Humans; Liver Cirrhosis; Mitochondria; Oleanolic Acid; Oligopeptides; Rats; Saponins; Triterpenes | 2016 |
Vinegar amount in the process affected the components of vinegar-baked Radix Bupleuri and its hepatoprotective effect.
Topics: Acetic Acid; Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Liver; Male; Oleanolic Acid; Plant Roots; Protective Agents; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins | 2016 |
Identification and Characterization of Two New Degradation Products of Saikosaponin A under Acid Hydrolytic Conditions.
Topics: Hydrolysis; Molecular Structure; Oleanolic Acid; Saponins | 2016 |
Oleanane triterpene saponins with cardioprotective activity from Clinopodium polycephalum.
Topics: Cardiotonic Agents; Drugs, Chinese Herbal; Hydrogen Peroxide; Lamiaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Saponins; Triterpenes | 2017 |
Suppressing effect of saikosaponin A, an active ingredient of Bupleurum falcatum, on chocolate self-administration and reinstatement of chocolate seeking in rats.
Topics: Animals; Beverages; Bupleurum; Chocolate; Feeding Behavior; Male; Motivation; Oleanolic Acid; Rats, Wistar; Reinforcement, Psychology; Saponins; Self Administration | 2017 |
Stimulation of Osteogenic Differentiation by Saikosaponin-A in Bone Marrow Stromal Cells Via WNT/β-Catenin Pathway.
Topics: Animals; beta Catenin; Bone Marrow Cells; Cell Differentiation; Female; Mesenchymal Stem Cells; Mice, Inbred C57BL; Oleanolic Acid; Osteogenesis; Saponins; Transcription Factors; Wnt Signaling Pathway | 2017 |
Saikosaponin a Induces Apoptosis through Mitochondria-Dependent Pathway in Hepatic Stellate Cells.
Topics: Animals; Apoptosis; Bupleurum; Caspase 3; Cell Proliferation; Cells, Cultured; Hepatic Stellate Cells; Mitochondria; Oleanolic Acid; Rats; Saponins; Stimulation, Chemical | 2017 |
Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Death; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Etoposide; Melanoma; Mice; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction | 2017 |
Anti-influenza triterpenoid saponins (saikosaponins) from the roots of Bupleurum marginatum var. stenophyllum.
Topics: Antiviral Agents; Bupleurum; Cell Line; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Oleanolic Acid; Plant Roots; Saponins; Structure-Activity Relationship | 2017 |
Content decline of SERCA inhibitors saikosaponin a and d attenuates cardiotoxicity and hepatotoxicity of vinegar-baked Radix bupleuri.
Topics: Acetic Acid; Animals; Animals, Newborn; Apoptosis; Bupleurum; Cardiotoxicity; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury; Female; Hep G2 Cells; Hot Temperature; Humans; Male; Myocytes, Cardiac; Oleanolic Acid; Plant Preparations; Plant Roots; Rats, Sprague-Dawley; Saponins; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2017 |
Saikosaponins induced hepatotoxicity in mice via lipid metabolism dysregulation and oxidative stress: a proteomic study.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bupleurum; Cholesterol; Cytochrome P-450 CYP2E1; Drugs, Chinese Herbal; Female; Hep G2 Cells; Humans; L-Lactate Dehydrogenase; Lipid Metabolism; Liver; Liver Diseases; Male; Mice; Nitric Oxide Synthase Type II; Oleanolic Acid; Oxidative Stress; Plant Roots; Proteomics; Saponins; Triglycerides | 2017 |
Reversal of P-glycoprotein-mediated multidrug resistance is induced by saikosaponin D in breast cancer MCF-7/adriamycin cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Oleanolic Acid; Rhodamine 123; Saponins; Time Factors | 2017 |
Effects of Saikosaponin D on apoptosis in human U87 glioblastoma cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Shape; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Phosphorylation; Saponins; Up-Regulation | 2017 |
Bioassay-guided isolation of saikosaponins with agonistic activity on 5-hydroxytryptamine 2C receptor from Bupleurum chinense and their potential use for the treatment of obesity.
Topics: Animals; Anti-Obesity Agents; Biological Assay; Bupleurum; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Serotonin 5-HT2 Receptor Agonists; Structure-Activity Relationship | 2017 |
Investigation of the Hepatoprotective Effect of Prunus mume Sieb. et Zucc Extract in a Mouse Model of Alcoholic Liver Injury Through High-Resolution Metabolomics.
Topics: Animals; Antioxidants; Chromatography, Liquid; Disease Models, Animal; Ethanol; Fatty Liver, Alcoholic; Humans; Liver; Male; Mass Spectrometry; Metabolomics; Mice; Mice, Inbred C57BL; Oleanolic Acid; Phosphatidylcholines; Prunus; Saponins | 2017 |
The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model.
Topics: Animals; Biological Transport; Dogs; Drugs, Chinese Herbal; Flavanones; Glucosides; Glycyrrhizic Acid; Humans; Madin Darby Canine Kidney Cells; Models, Biological; Monoterpenes; Oleanolic Acid; Permeability; Saponins; Verapamil | 2021 |
[Expression of key enzyme genes and content of saikosaponin in saikosaponin biosynthesis under drought stress in Bupleurum chinense].
Topics: Bupleurum; Droughts; Gene Expression Regulation, Plant; Oleanolic Acid; Plant Proteins; Saponins; Water | 2016 |
Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis.
Topics: Animals; Antidepressive Agents; Arousal; Corticosterone; Depression; Doublecortin Protein; Hippocampus; Hypothalamo-Hypophyseal System; Male; Motivation; Neurogenesis; Oleanolic Acid; Phytotherapy; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Saponins; Stress, Psychological | 2017 |
Identification of a specific agonist of human TAS2R14 from Radix Bupleuri through virtual screening, functional evaluation and binding studies.
Topics: Binding Sites; Bupleurum; Cell Degranulation; Cell Line; HEK293 Cells; Humans; Hydrogen Bonding; Immunoglobulin E; Mast Cells; Molecular Docking Simulation; Oleanolic Acid; Protein Binding; Receptors, G-Protein-Coupled; Saponins | 2017 |
Saikosaponin A attenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Brain-Derived Neurotrophic Factor; Depression; Female; Oleanolic Acid; Perimenopause; Rats; Rats, Wistar; Saponins; Stress, Psychological | 2018 |
SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST.
Topics: Animals; Astrocytes; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Transporter 1; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; MicroRNAs; Oleanolic Acid; Pentylenetetrazole; Proto-Oncogene Proteins c-fos; Rats, Wistar; Saponins; Transcription Factor AP-1 | 2017 |
Saikosaponin a Ameliorates LPS-Induced Acute Lung Injury in Mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage Fluid; Caspase 1; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; Neutrophil Infiltration; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Pulmonary Edema; Saponins; Tumor Necrosis Factor-alpha | 2018 |
Mechanism of the effect of saikosaponin on atherosclerosis in vitro is based on the MAPK signaling pathway.
Topics: Apoptosis Regulatory Proteins; Atherosclerosis; Biomarkers; Cytokines; Endothelial Cells; Humans; Lipoproteins, LDL; MAP Kinase Signaling System; NF-kappa B; Oleanolic Acid; Saponins; Superoxide Dismutase; Umbilical Veins | 2017 |
The effect of saikosaponin D on doxorubicin pharmacokinetics and its MDR reversal in MCF-7/adr cell xenografts.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Interactions; Drug Resistance, Neoplasm; Humans; MCF-7 Cells; Mice; Oleanolic Acid; Saponins; Xenograft Model Antitumor Assays | 2017 |
[Comparison of different administration routes of saikosaponin in plasma pharmacokinetics and brain pharmacokinetics].
Topics: Administration, Intranasal; Animals; Biological Availability; Brain Chemistry; Chromatography, High Pressure Liquid; Injections; Mice; Oleanolic Acid; Plasma; Saponins; Tandem Mass Spectrometry | 2017 |
Simultaneous determination of saikosaponin a, paeonol, and imperatorin, components of DA-9805, in rat plasma by LC-MS/MS and application to a pharmacokinetic study.
Topics: Acetophenones; Animals; Chromatography, Liquid; Drug Stability; Drugs, Chinese Herbal; Furocoumarins; Linear Models; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Sensitivity and Specificity; Tandem Mass Spectrometry | 2017 |
Saikosaponin-d-mediated downregulation of neurogenesis results in cognitive dysfunction by inhibiting Akt/Foxg-1 pathway in mice.
Topics: Animals; Avoidance Learning; Behavior, Animal; Cognitive Dysfunction; Dose-Response Relationship, Drug; Doublecortin Protein; Forkhead Transcription Factors; Hippocampus; Male; Maze Learning; Mice, Inbred ICR; Nerve Tissue Proteins; Neurogenesis; Oleanolic Acid; Proto-Oncogene Proteins c-akt; Saponins; Signal Transduction | 2018 |
Saikosaponin A inhibits compound 48/80-induced pseudo-allergy via the Mrgprx2 pathway in vitro and in vivo.
Topics: Animals; Edema; Immunoglobulin E; Male; Mast Cells; Mice; Oleanolic Acid; p-Methoxy-N-methylphenethylamine; Passive Cutaneous Anaphylaxis; Receptors, G-Protein-Coupled; Saponins | 2018 |
Estrogen receptor‑β‑dependent effects of saikosaponin‑d on the suppression of oxidative stress‑induced rat hepatic stellate cell activation.
Topics: Animals; Cell Proliferation; Cells, Cultured; Estradiol; Estrogen Receptor beta; Extracellular Matrix; Hepatic Stellate Cells; Hydrogen Peroxide; MAP Kinase Signaling System; Oleanolic Acid; Oxidative Stress; Rats; Saponins | 2018 |
[Research on topographic factors of ecology suitability regionalization of Bupleuri Radix in Hebei province].
Topics: Altitude; Bupleurum; China; Drugs, Chinese Herbal; Ecology; Ecosystem; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2017 |
Interaction between Saikosaponin D, Paeoniflorin, and Human Serum Albumin.
Topics: Binding Sites; Bupleurum; Drugs, Chinese Herbal; Glucosides; Humans; Hydrogen Bonding; Kinetics; Molecular Docking Simulation; Monoterpenes; Oleanolic Acid; Paeonia; Plant Extracts; Protein Binding; Protein Conformation, alpha-Helical; Protein Interaction Domains and Motifs; Saponins; Serum Albumin, Human; Thermodynamics | 2018 |
[Simultaneous determination of five saponins in Bupleuri Radix by HPLC-DAD dual wavelength method].
Topics: Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Saponins | 2018 |
Total Saikosaponins of Bupleurum yinchowense reduces depressive, anxiety-like behavior and increases synaptic proteins expression in chronic corticosterine-treated mice.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Bupleurum; Corticosterone; Depression; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Oleanolic Acid; Plant Extracts; Receptors, AMPA; Saponins; Signal Transduction | 2018 |
Saikosaponin‑d alleviates carbon‑tetrachloride induced acute hepatocellular injury by inhibiting oxidative stress and NLRP3 inflammasome activation in the HL‑7702 cell line.
Topics: Apoptosis; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Cytokines; Inflammasomes; Inflammation Mediators; Liver; Malondialdehyde; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Oxidative Stress; Saponins | 2018 |
Saikosaponin a Inhibits Cigarette Smoke-Induced Oxidant Stress and Inflammatory Responses by Activation of Nrf2.
Topics: Animals; Cigarette Smoking; Heme Oxygenase-1; Membrane Proteins; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Pneumonia; Saponins; Smoke | 2018 |
Saikosaponin-d inhibits proliferation by up-regulating autophagy via the CaMKKβ-AMPK-mTOR pathway in ADPKD cells.
Topics: AMP-Activated Protein Kinases; Autophagy; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Line, Transformed; Cell Proliferation; Gene Expression Regulation, Enzymologic; Humans; Oleanolic Acid; Polycystic Kidney, Autosomal Dominant; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
Saikosaponin A Inhibits LPS-Induced Endometritis in Mice Through Activating Nrf2 Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Endometritis; Female; Heme Oxygenase-1; Lipopolysaccharides; Mice; NF-E2-Related Factor 2; NF-kappa B; NF-KappaB Inhibitor alpha; Oleanolic Acid; Phosphorylation; Protective Agents; Saponins; Signal Transduction | 2018 |
[Neuroprotective effects and mechanism of saikosaponin A on acute spinal cord injury in rats].
Topics: Animals; Neuroprotective Agents; NF-kappa B; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Spinal Cord; Spinal Cord Injuries; Tumor Necrosis Factor-alpha | 2017 |
[The molecular identification of Bupleurum medicinal species and the quality investigation of Bupleuri Radix].
Topics: Bupleurum; China; Chromatography, High Pressure Liquid; DNA, Ribosomal Spacer; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins | 2017 |
[Identification on Five Kinds of Easily Confused Bupleurum Medicinal Materials].
Topics: Bupleurum; Chromatography, Thin Layer; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Saponins | 2016 |
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Topics: A549 Cells; Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Movement; Cell Proliferation; Drug Synergism; Feedback, Physiological; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Oleanolic Acid; Phosphorylation; Saponins; Tumor Suppressor Protein p53 | 2018 |
Saikosaponin D from Radix Bupleuri suppresses triple-negative breast cancer cell growth by targeting β-catenin signaling.
Topics: Apoptosis; beta Catenin; Cell Line; Cell Line, Tumor; Cell Proliferation; Female; HEK293 Cells; Humans; MCF-7 Cells; Medicine, Chinese Traditional; Oleanolic Acid; Plant Roots; Saponins; Triple Negative Breast Neoplasms; Wnt Proteins; Wnt Signaling Pathway | 2018 |
Saikosaponin B2 Suppresses Inflammatory Responses Through IKK/IκBα/NF-κB Signaling Inactivation in LPS-Induced RAW 264.7 Macrophages.
Topics: Animals; Anti-Inflammatory Agents; I-kappa B Proteins; Inflammation; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Oleanolic Acid; RAW 264.7 Cells; Saponins; Signal Transduction | 2019 |
Saikosaponin A modulates remodeling of Kv4.2-mediated A-type voltage-gated potassium currents in rat chronic temporal lobe epilepsy.
Topics: Animals; Epilepsy, Temporal Lobe; Injections, Intraperitoneal; Male; Molecular Conformation; Oleanolic Acid; Potassium Channel Blockers; Rats; Rats, Wistar; Saponins; Seizures; Shal Potassium Channels | 2018 |
Saikosaponin A Protects From Pressure Overload-Induced Cardiac Fibrosis via Inhibiting Fibroblast Activation or Endothelial Cell EndMT.
Topics: Animals; Blotting, Western; Cell Survival; Cells, Cultured; Echocardiography; Endothelial Cells; Endothelium; Fibrosis; Hemodynamics; Male; Mice; Myocytes, Cardiac; Oleanolic Acid; Rats; Saponins; Signal Transduction | 2018 |
Saikosaponin d causes apoptotic death of cultured neocortical neurons by increasing membrane permeability and elevating intracellular Ca
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Calcium; Cell Death; Cell Membrane Permeability; Cells, Cultured; Dose-Response Relationship, Drug; Female; Intracellular Fluid; Male; Mice; Mice, Inbred C57BL; Neocortex; Neurons; Oleanolic Acid; Saponins | 2019 |
Identification and Analysis of Compound Profiles of Sinisan Based on 'Individual Herb, Herb-Pair, Herbal Formula' before and after Processing Using UHPLC-Q-TOF/MS Coupled with Multiple Statistical Strategy.
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Multivariate Analysis; Oleanolic Acid; Principal Component Analysis; Saponins; Statistics as Topic; Tandem Mass Spectrometry | 2018 |
Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway.
Topics: Animals; Autophagy; Cells, Cultured; Extracellular Matrix; Fibrosis; Male; Matrix Metalloproteinases; Oleanolic Acid; Organotin Compounds; Pancreas; Pancreatic Stellate Cells; Pancreatitis, Chronic; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Saponins; Signal Transduction; Smad Proteins; TOR Serine-Threonine Kinases; Transforming Growth Factor beta1 | 2019 |
Inclusion complex of saikosaponin-d with hydroxypropyl-β-cyclodextrin: Improved physicochemical properties and anti-skin cancer activity.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents, Phytogenic; Bupleurum; Carcinoma, Squamous Cell; Cell Line, Tumor; Crystallography, X-Ray; Drug Compounding; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Oleanolic Acid; Saponins; Skin Neoplasms; Solubility; Spectroscopy, Fourier Transform Infrared; Water | 2019 |
Antiviral effect of saikosaponin B2 in combination with daclatasvir on NS5A resistance-associated substitutions of hepatitis C virus.
Topics: Antiviral Agents; Carbamates; Cells, Cultured; Drug Resistance, Viral; Drug Therapy, Combination; Hepacivirus; Hepatitis C; Humans; Imidazoles; Oleanolic Acid; Pyrrolidines; Saponins; Valine; Viral Nonstructural Proteins; Virus Replication | 2019 |
Untargeted Metabolomics Study of the In Vitro Anti-Hepatoma Effect of Saikosaponin d in Combination with NRP-1 Knockdown.
Topics: Carcinoma, Hepatocellular; Cell Survival; Gene Knockdown Techniques; Hep G2 Cells; Humans; Liver Neoplasms; Metabolic Networks and Pathways; Metabolomics; Molecular Docking Simulation; Molecular Targeted Therapy; Neuropilin-1; Oleanolic Acid; Saponins | 2019 |
Saikosaponin a ameliorates lipopolysaccharide and d‑galactosamine-induced liver injury via activating LXRα.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Galactosamine; Hep G2 Cells; Humans; Interleukin-1beta; Lipopolysaccharides; Liver; Liver X Receptors; Malondialdehyde; Mice, Inbred C57BL; Oleanolic Acid; Peroxidase; Saponins; Tumor Necrosis Factor-alpha | 2019 |
Saikosaponin A protects against dextran sulfate sodium-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Dextran Sulfate; Interleukin-1beta; Liver X Receptors; Male; Mice, Inbred C57BL; NF-kappa B; Oleanolic Acid; Saponins; Tumor Necrosis Factor-alpha | 2019 |
In vitro studies on the metabolism of saikogenins and the detection of their metabolites in authentic biosamples.
Topics: Animals; Chromatography, High Pressure Liquid; Hydroxylation; Male; Microsomes, Liver; Oleanolic Acid; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry | 2019 |
Saikosaponin‑D improves fear memory deficits in ovariectomized rats via the action of estrogen receptor‑α in the hippocampus.
Topics: Animals; Bupleurum; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Fear; Female; Fulvestrant; Gene Expression Regulation; Hippocampus; Medicine, Chinese Traditional; Memory Disorders; Oleanolic Acid; Ovariectomy; Rats; Saponins; Temporal Lobe | 2019 |
Modulation of LPA1 receptor-mediated neuronal apoptosis by Saikosaponin-d: A target involved in depression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line, Tumor; Coculture Techniques; Depression; Dose-Response Relationship, Drug; Humans; Lysophospholipids; Mice; Mice, Inbred ICR; Neurons; Oleanolic Acid; Random Allocation; Receptors, Lysophosphatidic Acid; Saponins | 2019 |
Effects of drought-re-watering-drought on the photosynthesis physiology and secondary metabolite production of Bupleurum chinense DC.
Topics: Bupleurum; Droughts; Oleanolic Acid; Photosynthesis; Plant Roots; Plants, Medicinal; Saponins; Secondary Metabolism; Soil; Stress, Physiological; Water | 2019 |
Modification of GSK3β/β-catenin signaling on saikosaponins-d-induced inhibition of neural progenitor cell proliferation and adult neurogenesis.
Topics: Animals; Avoidance Learning; beta Catenin; Cell Cycle; Cell Proliferation; Cell Survival; Dendrites; Glycogen Synthase Kinase 3 beta; Male; Maze Learning; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Oleanolic Acid; Saponins; Signal Transduction | 2019 |
Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cisplatin; Colchicine; Drug Resistance, Multiple; HEK293 Cells; Humans; Medicine, Chinese Traditional; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oleanolic Acid; Rhodamines; RNA, Messenger; Saponins; Up-Regulation | 2019 |
Pharmacokinetics and oral bioavailability studies of three saikogenins in rats using a validated UFLC-MS/MS method.
Topics: Animals; Biological Availability; Bupleurum; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Humans; Male; Oleanolic Acid; Plant Roots; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry | 2019 |
Antitumor effects of saikosaponin b2 on breast cancer cell proliferation and migration.
Topics: Adolescent; Adult; Animals; Breast Neoplasms; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Matrix Metalloproteinase 9; MCF-7 Cells; Mice; Microfilament Proteins; Middle Aged; Oleanolic Acid; Phosphoproteins; Saponins; STAT3 Transcription Factor; Young Adult | 2019 |
Effects of Animal Strain, Dose, and Cotreatment with Saikosaponin b
Topics: Animals; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Rats, Wistar; Saponins | 2019 |
[Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model].
Topics: Animals; Chemical and Drug Induced Liver Injury; Fatty Liver, Alcoholic; Oleanolic Acid; Saponins; Zebrafish | 2019 |
Saikosaponin C exerts anti-HBV effects by attenuating HNF1α and HNF4α expression to suppress HBV pgRNA synthesis.
Topics: Antiviral Agents; Hep G2 Cells; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 4; Humans; Oleanolic Acid; RNA; RNA Interference; RNA, Small Interfering; RNA, Viral; Saponins | 2019 |
[Effects of saikosaponin b_2 on inflammation and energy metabolism in mice with acute liver injury induced by LPS/GalN].
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytokines; Energy Metabolism; Galactosamine; Inflammation; Lipopolysaccharides; Liver; Mice; NF-kappa B; Oleanolic Acid; Random Allocation; Saponins; Sirtuins | 2019 |
Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model.
Topics: Animals; Antimetabolites, Antineoplastic; Antioxidants; Apoptosis; Cytokines; Diarrhea; Disease Models, Animal; Fluorouracil; Intestinal Mucosa; Intestines; Male; Mice; Mice, Inbred BALB C; Mucositis; Oleanolic Acid; Saponins | 2019 |
Saikosaponin A ameliorates nasal inflammation by suppressing IL-6/ROR-γt/STAT3/IL-17/NF-κB pathway in OVA-induced allergic rhinitis.
Topics: Animals; Cytokines; Disease Models, Animal; Immunoglobulin E; Immunoglobulin G; Inflammation; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Nasal Mucosa; NF-kappa B; Nuclear Receptor Subfamily 1, Group F, Member 3; Oleanolic Acid; Ovalbumin; Rhinitis, Allergic; Saponins; Signal Transduction; STAT3 Transcription Factor; Th17 Cells; Th2 Cells | 2020 |
Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of Saikosaponin A.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dopamine; Male; Oleanolic Acid; Proteome; Rats; Rats, Sprague-Dawley; Saponins; Stress, Psychological | 2020 |
Identification and characterization of saikosaponins as antagonists of transient receptor potential A1 channel.
Topics: Animals; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Hyperalgesia; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Neuralgia; Oleanolic Acid; Pain Measurement; Saponins; TRPA1 Cation Channel | 2020 |
Saikosaponin B2 attenuates kidney fibrosis via inhibiting the Hedgehog Pathway.
Topics: Animals; Fibroblasts; Fibrosis; Hedgehog Proteins; HEK293 Cells; Humans; Kidney; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NIH 3T3 Cells; Oleanolic Acid; Rats; Saponins; Signal Transduction; Smoothened Receptor; Zinc Finger Protein Gli2 | 2020 |
Saikosaponin d downregulates microRNA-155 and upregulates FGF2 to improve depression-like behaviors in rats induced by unpredictable chronic mild stress by negatively regulating NF-κB.
Topics: Animals; Behavior, Animal; Depression; Fibroblast Growth Factor 2; Hindlimb Suspension; Hippocampus; Male; MicroRNAs; Neurons; NF-kappa B; Oleanolic Acid; Rats, Sprague-Dawley; Saponins; Signal Transduction; Stress, Psychological | 2020 |
Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation.
Topics: Animals; Antidepressive Agents; Cell Survival; Cells, Cultured; Depression; Encephalitis; HMGB1 Protein; Lipopolysaccharides; Male; Mice, Inbred ICR; Microglia; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction; Toll-Like Receptor 4 | 2020 |
Saikosaponin-d ameliorates dextran sulfate sodium-induced colitis by suppressing NF-κB activation and modulating the gut microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colitis, Ulcerative; Cytokines; Dextran Sulfate; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Humans; Inflammation Mediators; Male; Mice; Mice, Inbred BALB C; Mucins; NF-kappa B; Oleanolic Acid; Saponins; Signal Transduction | 2020 |
Combination of saikosaponin c and telbivudine synergistically enhances the anti-HBV activity.
Topics: Antiviral Agents; DNA, Viral; Guanine; Hep G2 Cells; Hepatitis B Core Antigens; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Lamivudine; Oleanolic Acid; Saponins; Telbivudine | 2020 |
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Topics: COVID-19; Glycoproteins; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Oleanolic Acid; Saponins; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2021 |
Purposing Saikosaponins for the treatment of COVID-19.
Topics: Angiotensin-Converting Enzyme 2; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Cytokine Release Syndrome; Drug Repositioning; Humans; Immunologic Factors; Lymphocyte Activation; Molecular Docking Simulation; Oleanolic Acid; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Receptors, Virus; Saponins; SARS-CoV-2 | 2020 |
Differential Effects of Saikosaponins A, B2, B4, C and D on Alcohol and Chocolate Self-Administration in Rats.
Topics: Animals; Behavior, Addictive; Bupleurum; Chocolate; Ethanol; Female; Oleanolic Acid; Rats; Rats, Wistar; Saponins; Self Administration | 2020 |
Saikosaponin D inhibits autophagosome‑lysosome fusion and induces autophagy‑independent apoptosis in MDA‑MB‑231 breast cancer cells.
Topics: Apoptosis; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Breast Neoplasms; Caspase 3; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Lysosomes; Microtubule-Associated Proteins; Oleanolic Acid; p38 Mitogen-Activated Protein Kinases; Poly(ADP-ribose) Polymerases; Saponins | 2020 |
Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Movement; Cell Proliferation; Cells, Cultured; Fibrosis; Inflammasomes; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Pancreatic Stellate Cells; Rats; Saponins; Signal Transduction; TOR Serine-Threonine Kinases | 2020 |
Drought stress induces biosynthesis of flavonoids in leaves and saikosaponins in roots of Bupleurum chinense DC.
Topics: Bupleurum; Droughts; Flavonoids; Oleanolic Acid; Plant Leaves; Plant Roots; Saponins | 2020 |
Cytotoxicity of Saikosaponin A targets HEKa cell through apoptosis induction by ROS accumulation and inflammation suppression via NF-κB pathway.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Line; Humans; Imiquimod; Immunosuppression Therapy; Inflammation; Keratinocytes; Mice; NF-kappa B; Oleanolic Acid; Reactive Oxygen Species; Saponins; Signal Transduction | 2020 |
[Determination of Absolute Purities of Hygroscopic Substances by Quantitative NMR Analysis for the Standardization of Quantitative Reagents in the Japanese Pharmacopoeia (Part 1)].
Topics: Drug Contamination; Ginsenosides; Humidity; Hygroscopic Agents; Indicators and Reagents; Japan; Magnetic Resonance Spectroscopy; Oleanolic Acid; Pharmacopoeias as Topic; Psychotherapy, Brief; Saponins; Temperature; Water | 2020 |
Reparative and toxicity-reducing effects of liposome-encapsulated saikosaponin in mice with liver fibrosis.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Compounding; Drug Liberation; Hepatic Stellate Cells; Humans; Inhibitory Concentration 50; Liposomes; Liver; Liver Cirrhosis, Experimental; Male; Mice, Inbred C57BL; Oleanolic Acid; Protective Agents; Saponins; Thioacetamide | 2020 |
Saikosaponin d contributed to cancer chemotherapy induced neutropenia therapy by promoting neutrophil differentiation via activation CBL-dependent ERK pathway.
Topics: Animals; Antineoplastic Agents; Blood Bactericidal Activity; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Immunologic Factors; Infection Control; Macrophage Activation; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neutropenia; Neutrophils; Oleanolic Acid; Oncogene Protein v-cbl; Saponins | 2020 |
Saikosaponin D inhibits proliferation and induces apoptosis of non-small cell lung cancer cells by inhibiting the STAT3 pathway.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Humans; Lung Neoplasms; Oleanolic Acid; Saponins; STAT3 Transcription Factor | 2020 |
Utilizing methylglyoxal and D-lactate in urine to evaluate saikosaponin C treatment in mice with accelerated nephrotoxic serum nephritis.
Topics: Animals; Glomerulonephritis; Lactic Acid; Mice; Mice, Inbred C57BL; Oleanolic Acid; Pyruvaldehyde; Saponins | 2020 |
Saikosaponin A-Induced Gut Microbiota Changes Attenuate Severe Acute Pancreatitis through the Activation of Keap1/Nrf2-ARE Antioxidant Signaling.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidant Response Elements; Antioxidants; Gastrointestinal Microbiome; Kelch-Like ECH-Associated Protein 1; Male; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Pancreatitis; Rats; Rats, Sprague-Dawley; Saponins; Severity of Illness Index | 2020 |
Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells.
Topics: Bupleurum; Cells, Cultured; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Medicine, Chinese Traditional; Molecular Conformation; Oleanolic Acid; RNA, Messenger; Saponins | 2020 |
Saikosaponin a attenuates lead-induced kidney injury through activating Nrf2 signaling pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carps; Fish Diseases; Fish Proteins; Lead; Lead Poisoning; NF-E2-Related Factor 2; NF-kappa B; Oleanolic Acid; Oxidative Stress; Random Allocation; Saponins; Signal Transduction | 2021 |
Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7.
Topics: Analgesics; Angelica; Animals; Bupleurum; CHO Cells; Cricetulus; Disease Models, Animal; Drugs, Chinese Herbal; Female; Formaldehyde; Furocoumarins; Hot Temperature; Male; Medicine, Chinese Traditional; Mice; NAV1.7 Voltage-Gated Sodium Channel; Oleanolic Acid; Pain; Plant Roots; Saponins; Sodium | 2021 |
Effects of saikosaponin-d on CYP3A4 in HepaRG cell and protein-ligand docking study.
Topics: Bupleurum; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Humans; Ligands; Molecular Docking Simulation; Oleanolic Acid; Saponins | 2021 |
Determination of Absolute Purities of Hygroscopic Substances by Quantitative NMR Analysis for the Standardization of Quantitative Reagents in the Japanese Pharmacopoeia (Part 2).
Topics: Anthracenes; Ginsenosides; Humidity; Hygroscopic Agents; Japan; Magnetic Resonance Spectroscopy; Oleanolic Acid; Saponins | 2021 |
Saikosaponin a contributed to CCIN treatment by promoting neutrophil bactericidal activity via activation CBL-dependent ERK pathway.
Topics: Blotting, Western; Cell Differentiation; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; MAP Kinase Signaling System; Neutropenia; Neutrophils; Oleanolic Acid; Proto-Oncogene Proteins c-cbl; Saponins | 2021 |
Computational assessment of saikosaponins as adjuvant treatment for COVID-19: molecular docking, dynamics, and network pharmacology analysis.
Topics: COVID-19 Drug Treatment; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Oleanolic Acid; Protein Domains; Saponins | 2021 |
Saikosaponin A improved depression-like behavior and inhibited hippocampal neuronal apoptosis after cerebral ischemia through p-CREB/BDNF pathway.
Topics: Animals; Antidepressive Agents; Apoptosis; Behavior, Animal; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Dentate Gyrus; Depression; Disease Models, Animal; Hippocampus; Ischemic Stroke; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Recovery of Function; Saponins | 2021 |
Saikosaponin-d increases radiation-induced apoptosis of hepatoma cells by promoting autophagy via inhibiting mTOR phosphorylation.
Topics: Apoptosis; Autophagy; Carcinoma, Hepatocellular; Cell Line, Tumor; Chemoradiotherapy; Humans; Liver Neoplasms; Oleanolic Acid; Phosphorylation; Radiation Tolerance; Saponins; TOR Serine-Threonine Kinases | 2021 |
Saikosaponin-d improved the stemness of mouse neural stem cells and increased their thermotolerance potential.
Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Female; Male; Mice; Neural Stem Cells; Neurogenesis; Oleanolic Acid; Saponins; Thermotolerance | 2021 |
Facile Synthesis of Saikosaponins.
Topics: Glycosylation; Molecular Structure; Oleanolic Acid; Saponins | 2021 |
Ultra-high performance supercritical fluid chromatography method for separation and quantitation of saikosaponins in herbal medicine.
Topics: Chromatography, High Pressure Liquid; Chromatography, Supercritical Fluid; Drugs, Chinese Herbal; Herbal Medicine; Oleanolic Acid; Saponins | 2021 |
Saikosaponin-d protects against liver fibrosis by regulating the estrogen receptor-β/NLRP3 inflammasome pathway.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Estrogen Receptor beta; Inflammasomes; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Oleanolic Acid; Protective Agents; Saponins | 2021 |
Saikosaponins and the deglycosylated metabolites exert liver meridian guiding effect through PXR/CYP3A4 inhibition.
Topics: Bupleurum; Carcinoma, Hepatocellular; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Gene Expression Regulation; Hep G2 Cells; Humans; Inhibitory Concentration 50; Liver Neoplasms; Meridians; Microsomes, Liver; Oleanolic Acid; Pregnane X Receptor; Saponins; Time Factors | 2021 |
Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Topics: Animals; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Ginsenosides; Linear Models; Male; Oleanolic Acid; Rats; Rats, Wistar; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tablets; Tandem Mass Spectrometry | 2021 |
Saikosaponin-d Alleviates Renal Inflammation and Cell Apoptosis in a Mouse Model of Sepsis via TCF7/FOSL1/Matrix Metalloproteinase 9 Inhibition.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Line; Disease Models, Animal; Epithelial Cells; Hepatocyte Nuclear Factor 1-alpha; Humans; Inflammation; Kidney; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Nephritis; Oleanolic Acid; Proto-Oncogene Proteins c-fos; Saponins; Sepsis | 2021 |
Saikosaponin a promotes sleep by decreasing neuronal activities in the lateral hypothalamus.
Topics: Animals; Electroencephalography; Humans; Hypothalamic Area, Lateral; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Saponins; Sleep; Sleep Initiation and Maintenance Disorders | 2022 |
Antitumor Effect of Saikosaponin A on Human Neuroblastoma Cells.
Topics: Apoptosis; Bupleurum; Cell Line, Tumor; Cell Movement; Cell Proliferation; China; Humans; Inhibitory Concentration 50; Neuroblastoma; Oleanolic Acid; Plant Extracts; Saponins; Signal Transduction | 2021 |
Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2-STAT3 signaling.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Cycle Proteins; Cell Differentiation; Dendritic Cells; Encephalomyelitis, Autoimmune, Experimental; Humans; Interleukin-10; Janus Kinase 2; Membrane Transport Proteins; Mice; Oleanolic Acid; Phosphorylation; Protein Binding; Saponins; Signal Transduction; STAT3 Transcription Factor | 2021 |
Saikosaponin-d alleviates hepatic fibrosis through regulating GPER1/autophagy signaling.
Topics: Animals; Autophagy; Carbon Tetrachloride; Cells, Cultured; China; Fibrosis; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Receptors, Estrogen; Receptors, G-Protein-Coupled; Saponins; Signal Transduction; Transforming Growth Factor beta | 2021 |
Saikosaponin A and D Inhibit Adipogenesis via the AMPK and MAPK Signaling Pathways in 3T3-L1 Adipocytes.
Topics: 3T3-L1 Cells; Adenylate Kinase; Adipocytes; Adipogenesis; Adiponectin; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Obesity Agents; Bupleurum; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Gene Expression; Lipogenesis; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Obesity; Oleanolic Acid; Phosphorylation; Plant Extracts; PPAR gamma; Saponins; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2021 |
Transcriptome and metabolome analysis to reveal major genes of saikosaponin biosynthesis in Bupleurum chinense.
Topics: Bupleurum; Humans; Metabolome; Oleanolic Acid; Plant Roots; Saponins; Transcriptome | 2021 |
Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study.
Topics: Amino Acid Motifs; Binding Sites; Cell Adhesion Molecules; Computer Simulation; COVID-19; Cytokines; Epitopes; Flavanones; Glucosides; Glycosides; Humans; Lectins, C-Type; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Monosaccharides; Oleanolic Acid; Polysaccharides; Receptors, Cell Surface; Saponins; Spike Glycoprotein, Coronavirus | 2021 |
Inhibition of Lipopolysaccharide-Induced Inflammatory Bone Loss by Saikosaponin D is Associated with Regulation of the RANKL/RANK Pathway.
Topics: Animals; Anti-Inflammatory Agents; Bone Resorption; Cell Differentiation; Cells, Cultured; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Oleanolic Acid; Osteoclasts; Osteogenesis; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Saponins | 2021 |
Saikosaponin D Alleviates DOX-induced Cardiac Injury In Vivo and In Vitro.
Topics: Antioxidants; Apoptosis; Cardiotoxicity; Doxorubicin; Fibrosis; Humans; Myocytes, Cardiac; Oleanolic Acid; Oxidative Stress; Reactive Oxygen Species; Saponins | 2022 |
Saikosaponin-D Mitigates Oxidation in SH-SY5Y Cells Stimulated by Glutamate Through Activation of Nrf2 Pathway: Involvement of PI3K.
Topics: Apoptosis; Cell Line, Tumor; Glutamic Acid; Heme Oxygenase-1; Humans; Malondialdehyde; Neurodegenerative Diseases; Neuroprotective Agents; NF-E2-Related Factor 2; Oleanolic Acid; Oxidative Stress; Phosphatidylinositol 3-Kinases; Reactive Oxygen Species; Saponins; Signal Transduction | 2022 |
Development of Saikosaponin D Liposome Nanocarrier with Increased Hepatoprotective Effect Against Alcoholic Hepatitis Mice.
Topics: Animals; Hepatitis, Alcoholic; Liposomes; Mice; Oleanolic Acid; Saponins | 2021 |
Saikosaponin B1 and Saikosaponin D inhibit tumor growth in medulloblastoma allograft mice via inhibiting the Hedgehog signaling pathway.
Topics: Allografts; Animals; Cerebellar Neoplasms; Hedgehog Proteins; Medulloblastoma; Mice; Oleanolic Acid; Saponins; Signal Transduction; Zinc Finger Protein GLI1 | 2022 |
Overexpression of BcERF3 increases the biosynthesis of saikosaponins in Bupleurum chinense.
Topics: Bupleurum; Oleanolic Acid; Plant Roots; Saponins | 2022 |
Saikosaponin A Inhibits Growth of Human Bladder Carcinoma T24 and 5637 Cells Both in Vitro and in Vivo.
Topics: Animals; Apoptosis; Bisbenzimidazole; Carcinoma; Caspases; Cell Line, Tumor; Cell Proliferation; Humans; Mice; Oleanolic Acid; Saponins; Urinary Bladder; Urinary Bladder Neoplasms | 2022 |
Saikosaponin A and Saikosaponin C Reduce TNF-α-Induced TSLP Expression through Inhibition of MAPK-Mediated EGR1 Expression in HaCaT Keratinocytes.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis, Atopic; Early Growth Response Protein 1; HaCaT Cells; Humans; Keratinocytes; Mice; Oleanolic Acid; Saponins; Skin Diseases; Thymic Stromal Lymphopoietin; Tumor Necrosis Factor-alpha | 2022 |
Production of Prosaikogenin F, Prosaikogenin G, Saikogenin F and Saikogenin G by the Recombinant Enzymatic Hydrolysis of Saikosaponin and their Anti-Cancer Effect.
Topics: Humans; Hydrolysis; Oleanolic Acid; Sapogenins; Saponins | 2022 |
Saikosaponin D attenuates metabolic associated fatty liver disease by coordinately tuning PPARα and INSIG/SREBP1c pathway.
Topics: Animals; Diet, High-Fat; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oleanolic Acid; PPAR alpha; Saponins; Signal Transduction; Sterol Regulatory Element Binding Protein 1 | 2022 |
Synergistic neuroprotective effect of saikosaponin A and albiflorin on corticosterone-induced apoptosis in PC12 cells via regulation of metabolic disorders and neuroinflammation.
Topics: Animals; Apoptosis; Bridged-Ring Compounds; Corticosterone; Humans; Metabolic Diseases; Neuroinflammatory Diseases; Neuroprotective Agents; Oleanolic Acid; PC12 Cells; Purines; Rats; Saponins | 2022 |
Drought Stress Stimulates the Terpenoid Backbone and Triterpenoid Biosynthesis Pathway to Promote the Synthesis of Saikosaponin in
Topics: Bupleurum; Droughts; Oleanolic Acid; Plant Roots; Saponins; Terpenes | 2022 |
[Simultaneous determination and pharmacokinetic study of five compounds from total extract of Clinopodium chinense in abnormal uterine bleeding rat plasma by UPLC-MS/MS].
Topics: Administration, Oral; Animals; Apigenin; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drugs, Chinese Herbal; Female; Flavonoids; Hesperidin; Lamiaceae; Mifepristone; Misoprostol; Oleanolic Acid; Plant Extracts; Rats; Saponins; Tandem Mass Spectrometry; Uterine Hemorrhage | 2022 |
Saikosaponin A and Its Epimers Alleviate LPS-Induced Acute Lung Injury in Mice.
Topics: Acetic Acid; Acute Lung Injury; Animals; Anti-Inflammatory Agents; Interleukin-6; Lipopolysaccharides; Mice; NF-kappa B; Oleanolic Acid; Saponins; Tumor Necrosis Factor-alpha | 2023 |
Saikosaponin D exerts cytotoxicity on human endometrial cancer ishikawa cells by inducing apoptosis and inhibiting metastasis through MAPK pathways.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Female; HEK293 Cells; Humans; Oleanolic Acid; Saponins | 2023 |
[Correlations between appearance traits and internal quality of Bupleurum scorzonerifolium roots based on theory of "quality evaluation through morphological identification"].
Topics: Bupleurum; Oils, Volatile; Oleanolic Acid; Plant Roots; Saponins | 2023 |
Quantitative and Differential Analysis between
Topics: Bupleurum; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Mass Spectrometry; Oils, Volatile; Oleanolic Acid; Plant Roots; Saponins | 2023 |