oleanolic acid has been researched along with hederagenin in 114 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.51) | 18.7374 |
| 1990's | 8 (7.02) | 18.2507 |
| 2000's | 20 (17.54) | 29.6817 |
| 2010's | 62 (54.39) | 24.3611 |
| 2020's | 20 (17.54) | 2.80 |
| Authors | Studies |
|---|---|
| Gauthier, C; Girard-Lalancette, K; Legault, J; Mshvildadze, V; Pichette, A | 1 |
| Aquino, R; Capasso, A; Festa, M; Mencherini, T; Picerno, P; Russo, P | 1 |
| Chen, K; Huang, X; Peng, Y; Qiu, Y; Shi, Y; Sun, D; Wang, H; Wang, Q; Xiao, S; Yu, F; Yu, M; Zhang, C; Zhang, L; Zhang, Z; Zhao, C; Zheng, Y; Zhou, D; Zhu, L | 1 |
| Cheng, G; Gao, H; Li, Y; Sun, XL; Tang, HF; Wang, XY; Zhang, W | 1 |
| Wang, WW; Xu, SH; Yu, BY; Zhang, C; Zhang, J; Zhang, YY; Zhao, YZ | 1 |
| Chen, Z; Cheng, YY; Duan, HQ; Goto, M; Huang, KY; Lee, KH; Ling, Y; Liu, YL; Morris-Natschke, SL; Tong, XH; Yang, PC; Yang, SL | 1 |
| Fukushima, EO; Muranaka, T; Nomura, Y; Vo, NNQ | 1 |
| Chen, C; Cheng, K; Dai, L; Hu, K; Li, H; Liu, L; Sun, H; Wen, X; Xu, Q; Yuan, H | 1 |
| Cheng, XF; Liu, J; Xia, L | 1 |
| Pourrat, H; Regerat, F; Texier, O | 1 |
| Kato, H; Park, EH; Takagi, K | 1 |
| Fujimoto, Y; Hara, N; Jayasinghe, L; Shimada, H | 1 |
| Ebashi, J; Furumoto, T; Isiguro, I; Nagamura, Y; Nishida, K; Saito, S; Sumita, S | 1 |
| Chen, M; Nanz, D; Sticher, O; Wu, WW | 1 |
| Abubakirov, NK; Isaev, MI; Timbekova, AE | 1 |
| Kirmizigül, S; Rose, ME | 1 |
| Kojima, K; Ogihara, Y; Zhu, XB | 1 |
| Chang, HW; Kang, SS; Kim, HP; Kim, SY; Son, KH | 1 |
| Ahn, KS; Jung, KY; Lee, HK; Lee, IS; Oh, SR; Park, SH; Son, KH | 1 |
| Jung, GO; Kim, DW; Lee, KT; Park, HJ; Park, KY; Sohn, IC | 1 |
| Kwon, SH; Lee, JH; Lee, KH; Lee, KT; Miyamoto, K; Park, HJ | 1 |
| Hahn, DR; Kim, SU; Lee, MW | 1 |
| Wang, XC | 1 |
| Bosselaers, J; De Kimpe, N; He, W; Maes, L; Van Puyvelde, L | 1 |
| WALTER, ED | 1 |
| Chwalek, M; Plé, K; Voutquenne-Nazabadioko, L | 1 |
| Itoriya, A; Mehta, BK; Mehta, D | 1 |
| Choi, J; Jung, HJ; Lee, KT; Park, HJ | 1 |
| Sun, H; Tao, JH; Ye, WC; Zhang, XQ; Zhang, XT; Zhao, SX | 1 |
| Bae, K; Hung, TM; Jin, W; Seong, YH; Song, KS; Thuong, PT | 1 |
| Lin, R; Liu, G; Yu, Z; Zhang, J; Zheng, J | 1 |
| Bobichon, H; Chwalek, M; Lalun, N; Plé, K; Voutquenne-Nazabadioko, L | 1 |
| Alabdul Magid, A; Harakat, D; Lavaud, C; Moretti, C; Renimel, I; Voutquenne-Nazabadioko, L | 1 |
| Chen, J; Li, HJ; Li, P; Liu, YS; Xu, XF; Zhang, ZY; Zhao, HN | 1 |
| Balestrazzi, A; Biazzi, E; Cammareri, M; Confalonieri, M; Conicella, C; Fevereiro, MP; Pecchia, P; Tava, A | 1 |
| Häberlein, H; Jakobs, D; Prenner, L; Runkel, F; Sieben, A; Sorkalla, T; Wolf, A | 1 |
| Hu, YZ; Li, P; Xu, L; Yang, ZL; Zhou, YQ | 1 |
| Andersen, SB; Bak, S; Ekstrøm, CT; Kuzina, V; Nielsen, JK; Olsen, CE | 1 |
| Cho, JH; Kim, CJ; Lee, JY; Sim, SS; Whang, WK | 1 |
| Chen, G; Fan, J; Li, X; Xu, Q; Yang, S; Zhang, M | 1 |
| Nagao, T; Nielsen, JK; Okabe, H; Shinoda, T | 1 |
| Dixon, RA; Huhman, DV; Modolo, LV; Naoumkina, MA; Sumner, LW; Tang, Y; Urbanczyk-Wochniak, E | 1 |
| Fu, Q; Jiang, Y; Shi, S; Tu, P; Zan, K; Zhao, M; Zhou, S | 1 |
| Huang, HC; Hwang, TL; Kuo, LM; Kuo, YH; Wang, CC; Wu, YC; Wu, YH | 1 |
| Chen, L; Li, G; Wan, X; Xu, J; Yang, X; Zhang, C | 1 |
| Ding, L; Hu, L; Qi, X; Shakya, S; Yang, X; Yang, Z; Zhu, H | 1 |
| Chi, MG; Gao, N; Jin, ZL; Xu, JP; Yang, XM; Zhou, D | 1 |
| Gao, L; Lin, CZ; Zhao, ZX; Zhu, CC | 1 |
| Kırmızıgül, S; Sarıkahya, NB | 1 |
| Cheng, HL; Cheng, JJ; Huang, HT; Kuo, LM; Kuo, YH; Liao, CC; Zhang, LJ | 1 |
| Augustin, JM; Bak, S; Drok, S; Ekstrøm, CT; Hansen, EH; Hauser, T; Khakimov, B; Kuzina, V; Nielsen, JK; Olsen, CE; Sanmiya, K; Shinoda, T | 1 |
| Bi, JL; Hu, GW; Long, CL; Su, Y; Wang, YH; Xu, JJ; Yang, J; Yin, GF | 1 |
| Fukushima, EO; Muranaka, T; Ohyama, K; Saito, K; Sawai, S; Seki, H; Suzuki, M | 1 |
| Le Duff, CS; Lorent, J; Mingeot-Leclercq, MP; Quetin-Leclercq, J | 1 |
| Chen, ML; Kong, FY; Li, QQ; Liu, CS; Ma, CH; Tian, ZH; Wang, Y; Xiao, Y; Xu, WY | 1 |
| Chang, YX; Gao, XM; Han, LF; Huo, Y; Liu, EW; Wang, JL; Wang, L; Wang, T | 1 |
| Brasseur, R; Domenech, Ò; Lins, L; Lorent, J; Mingeot-Leclercq, MP; Quetin-Leclercq, J | 1 |
| Ding, L; Yang, Z; Zhang, R; Zhu, H | 1 |
| Huang, W; Meng, Z; Wang, Z; Xiao, W; Yan, L; Yang, X; Yang, Z; Yuan, Y; Zhang, C | 1 |
| Byrd, J; Dunlap, N; He, C; Wright, ME | 1 |
| Feng, L; Gu, JF; Jia, XB; Li, Y; Liu, BX; Wang, RP; Wu, J; Yuan, JR; Zhao, BJ; Zhou, JY; Zou, X | 1 |
| Cheng, YF; Guo, HB; Huang, F; Liang, BF; Wang, GH; Wang, HT; Xu, JP; Yuan, X; Zhang, MZ | 1 |
| Feng, H; Wang, ZZ; Zhang, Z | 1 |
| Du, Z; Feussi Talla, M; Gatsing, D; Kamdem Wabo, H; Kuiate, JR; Luo, X; Mouokeu, RS; Nanfack Donfack, AR; Njateng, GS; Tane, P | 1 |
| Altman, E; Bi, W; Gao, Y; He, C; Wu, G | 1 |
| Barbosa, LC; Csuk, R; Demuner, AJ; Heller, L; Rodríguez-Hernández, D | 2 |
| An, WG; Cho, IJ; Chun, W; Jegal, KH; Ju, SA; Jung, JY; Kim, SC; Kim, SH; Kim, YW; Ku, SK; Lee, C; Lee, CW; Park, SM; Son, Y; Zhao, R | 1 |
| Li, QR; Qiu, Z; Wei, Q; Xu, F; Yin, H | 1 |
| Delemasure, S; Dutartre, P; Lacaille-Dubois, MA; Mitaine-Offer, AC; Miyamoto, T; Rezgui, A; Tanaka, C | 1 |
| Li, SH; Yao, YZ | 1 |
| Jing, F; Zhang, H; Zhang, Z | 1 |
| Barbosa, LCA; de Almeida, RM; Demuner, AJ; Ferreira, SR; Fujiwara, RT; Rodríguez-Hernández, D | 1 |
| Chu, ZY; Diao, Z; Feng, X; Liu, Z; Lu, YH; Zou, YX | 1 |
| Law, BY; Liu, L; Lo, AC; Wong, VK; Wu, AG; Zeng, W; Zhu, YZ | 1 |
| Bak, S; Engelsen, SB; Godejohann, M; Khakimov, B; Tseng, LH | 1 |
| An, JH; Chung, KH; Kim, GJ; Lee, KJ; Song, DH; Yoo, HS | 1 |
| Avato, P; Biazzi, E; Mella, M; Quadrelli, P; Tava, A | 1 |
| Chłopecka, M; Dziekan, N; Karlik, W; Mendel, M | 1 |
| Barbosa, LCA; Csuk, R; de Almeida, RM; Demuner, AJ; Ferreira, SR; Fujiwara, RT; Heller, L; Nain-Perez, A; Rodríguez-Hernández, D | 1 |
| Bi, Y; Fu, FH; Lei, L; Liu, JQ; Liu, XX; Luo, XM; Wang, HB; Wang, KY; Wang, X; Yang, YT; Zhai, R | 1 |
| Choi, YE; Chun, JH; Han, JY; Hwang, HS; Lee, H; Oh, SA; Park, SB | 1 |
| Bi, Y; Fu, F; Guan, D; Lei, L; Liu, JQ; Lu, J; Tian, J; Wang, H; Yan, C; Yang, G; Yang, Y; Zhai, R | 1 |
| Gokturk, RS; Kirmizigul, S; Nalbantsoy, A; Sarikahya, NB; Sumbul, H; Top, H | 1 |
| Baek, S; Kim, EH; Lee, J; Roh, JL; Shin, D | 1 |
| Agerbirk, N; Bak, S; Erthmann, PØ | 1 |
| Dai, ZB; Li, WX; Lu, FP; Ma, XL; Wang, D; Zhang, XL | 1 |
| Cai, DS; Chen, M; Fang, K; Guo, WB; Han, YT; Lei, HM; Ma, T; Wang, H; Wang, PL; Wu, GR; Xue, NN; Yang, YQ; Zhang, XH; Zhang, XY | 1 |
| Bi, Y; Liu, XX; Qi, JG; Ren, QW; Tian, JW; Wang, BH; Wang, HB; Wang, X; Yang, YT; Zhai, R | 1 |
| Bamburowicz-Klimkowska, M; Chłopecka, M; Karlik, W; Mendel, M | 1 |
| Bak, S; Cárdenas, PD; Cozzi, F; Hauser, TP; Jensen, KR; Khakimov, B; Liu, Q; Olsen, CE | 1 |
| Ataide Martins, JP; Barbosa, LCA; Csuk, R; Demuner, AJ; Fischer Nee Heller, L; Rodríguez-Hernández, D | 1 |
| Cai, L; Fang, L; Liu, M | 1 |
| Delaude, C; Lacaille-Dubois, MA; Mitaine-Offer, AC; Miyamoto, T; Petit, B; Tanaka, C | 1 |
| Akhtar, M; Chen, Y; Deng, G; Guo, M; Shaukat, A; Umar, T; Wang, Y; Yang, M; Zahoor, A | 1 |
| Ding, J; Li, Y; Liang, J; Lin, X; Liu, Q; Song, F; Su, Y; Tian, K; Wang, D; Wang, Z; Xu, J; Zhan, Y; Zhao, J | 1 |
| Deng, L; He, Y; Huang, Q; Ma, W; Xiong, G | 1 |
| El Hazzam, K; El Kacimi, K; Hafsa, J; Mhada, M; Sobeh, M; Taourirte, M; Yasri, A | 1 |
| Chen, BQ; Liu, QH; Liu, X; Liu, YM; Sun, L | 1 |
| Chan, MT; Chen, B; Du, B; Gu, J; Ho, IH; Liu, Q; Liu, X; Tan, Y; Wang, K; Wei, X; Wu, WK; Xiao, J; Yin, T; Zhan, Y; Zhang, L; Zhang, W | 1 |
| Bi, Y; Chen, X; Huang, W; Li, X; Liang, K; Liu, S; Ma, M; Wang, B; Wang, H; Zeng, W | 1 |
| Abaci, H; Akagac, G; Nalbantsoy, A; Sarikahya, NB | 1 |
| Deng, H; Jin, CM; Jin, R; Quan, ZS; Shen, QK; Zhang, RH | 1 |
| Haddad, M; Lavedan, P; Le Doux Kamto, E; Mbing, JN; Messi, LM; Moffi Biang, AE; Noté, OP; Pegnyemb, DE; Simo, LM; Vedrenne, M | 1 |
| Deng, X; Ding, R; Hou, Y; Lv, Q; Nie, J; Qiu, J; Xu, X; Zhang, Y | 1 |
| An, JH; Choi, EJ; Chung, KH; Kim, EK; Kim, GJ; Lee, KJ; Lee, YR; Ratih, K; Shin, JS | 1 |
| Arbeláez, N; Archbold, R; Echeverri, F; Escobar, G; Higuita-Castro, JL; Montoya, A; Piragauta, SP; Quiñones, W; Restrepo, AM; Robledo, SM; Torres, F; Vélez, ID | 1 |
| Baek, SJ; Cha, S; Kim, A; Kim, NS; Lee, H; Park, M; Park, SM; Yi, JM | 1 |
| Bi, Y; Cheng, H; Huang, W; Liu, S; Qiao, H; Tian, Q; Wang, H; Wang, L; Wang, R; Wang, Y; Xu, S | 1 |
| He, L; Yang, W | 1 |
| Wang, J; Wang, Q; Yang, M | 1 |
| Han, RY; Jia, J; Liu, XH; Tan, RZ; Wang, L; Xie, KH; Zhong, X | 1 |
| Alejo-Jacuinde, G; Alolga, RN; Cai, YY; Chen, X; Chen, Y; Ding, H; Du, J; Gao, W; Guo, D; Herrera-Estrella, L; Huang, FQ; Kan, X; Li, P; Lu, X; Qi, LW; Tran, LP; Wang, X; Wei, X; Xiang, Y; Yin, X; Zhang, B | 1 |
| Bi, Y; Fang, X; Han, S; Li, H; Lu, X; Xie, W; Yang, D | 1 |
3 review(s) available for oleanolic acid and hederagenin
| Article | Year |
|---|---|
Chemistry and biological activity of triterpenoid glycosides from Medicago sativa.
Topics: Bacteria; Fungi; Medicago sativa; Molecular Structure; Oleanolic Acid; Plant Development; Plants; Saponins; Triterpenes | 1996 |
An Insight into Saponins from Quinoa (
Topics: Anti-Inflammatory Agents; Chenopodium quinoa; Chromatography, High Pressure Liquid; Hot Temperature; Oleanolic Acid; Plant Extracts; Saponins; Seeds; Solid Phase Extraction; Sonication; Water | 2020 |
Advances in the anti-tumor potential of hederagenin and its analogs.
Topics: Anti-Inflammatory Agents; Cell Line, Tumor; Oleanolic Acid; Pentacyclic Triterpenes | 2023 |
111 other study(ies) available for oleanolic acid and hederagenin
| Article | Year |
|---|---|
Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.
Topics: Animals; Cell Line, Tumor; Cell Membrane Permeability; Erythrocytes; Hemolysis; Humans; Oleanolic Acid; Saponins; Sheep; Triterpenes | 2009 |
Triterpenoid constituents from the roots of Paeonia rockii ssp. rockii.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; Biphenyl Compounds; Caspase Inhibitors; Drug Screening Assays, Antitumor; HEK293 Cells; HT29 Cells; Humans; Italy; Oleanolic Acid; Paeonia; Pentacyclic Triterpenes; Picrates; Plant Roots; Triterpenes | 2011 |
Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Cytotoxins; HEK293 Cells; Hemolytic Agents; Hepacivirus; Humans; Oleanolic Acid; Rabbits; Structure-Activity Relationship; Virus Internalization | 2013 |
Bioactive oleanane-type saponins from the rhizomes of Anemone taipaiensis.
Topics: Anemone; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Drug Screening Assays, Antitumor; HeLa Cells; Hep G2 Cells; HL-60 Cells; Humans; Magnetic Resonance Spectroscopy; Molecular Conformation; Oleanolic Acid; Rhizome; Saponins; Spectrometry, Mass, Electrospray Ionization | 2013 |
Microbial hydroxylation and glycosylation of pentacyclic triterpenes as inhibitors on tissue factor procoagulant activity.
Topics: Glycosylation; Humans; Hydroxylation; Structure-Activity Relationship; Thromboplastin; Triterpenes | 2017 |
Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
Topics: A549 Cells; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Design; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Nitric Oxide; Nitric Oxide Donors; Oleanolic Acid; Protein Kinase Inhibitors | 2019 |
Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
Topics: Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Humans; Lipoxygenase Inhibitors; Pentacyclic Triterpenes; Structure-Activity Relationship | 2019 |
Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Glycyrrhizic Acid; Humans; Interleukin-6; Liver; Macrophages; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Oleanolic Acid; Pentacyclic Triterpenes; Phosphorylation; Sapogenins; Saponins; Tumor Necrosis Factor-alpha | 2021 |
[Anti-inflammatory effects of fulvotomentosasides].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Drugs, Chinese Herbal; Female; Male; Mice; Oleanolic Acid; Rats; Sapogenins; Triterpenes | 1988 |
[Use of a strain of Aspergillus niger for purification of a hederagenin rhamnoglucoside from tubers of ficaria(Ficaria ranunculoides Moench)].
Topics: Aspergillus niger; Oleanolic Acid; Plants, Medicinal; Sapogenins; Saponins | 1982 |
Anti-inflammatory activities of hederagenin and crude saponin isolated from Sapindus mukorossi Gaertn.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Capillary Permeability; Edema; Female; Granuloma; Oleanolic Acid; Plants; Rats; Sapogenins; Saponins | 1980 |
Hederagenin glycosides from Pometia eximia.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Carbohydrate Conformation; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Molecular Structure; Oleanolic Acid; Plant Stems; Plants, Medicinal; Saponins; Spectrometry, Mass, Fast Atom Bombardment | 1995 |
Comparison of cytoprotective effects of saponins isolated from leaves of Aralia elata Seem. (Araliaceae) with synthesized bisdesmosides of oleanoic acid and hederagenin on carbon tetrachloride-induced hepatic injury.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon Tetrachloride Poisoning; Cell Survival; Chemical and Drug Induced Liver Injury; In Vitro Techniques; Oleanolic Acid; Plants, Medicinal; Rats; Rats, Wistar; Saponins | 1993 |
Leonticins A-C, three octasaccharide saponins from Leontice kiangnanensis.
Topics: Anti-Inflammatory Agents; Carbohydrate Sequence; Hydrogen-Ion Concentration; Hydrolysis; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Oligosaccharides; Plant Extracts; Plants, Medicinal; Polysaccharides; Saponins; Spectrometry, Mass, Fast Atom Bombardment; Steroids | 1996 |
Hederagenin glycosides from the flowers of Cephalaria transsylvanica.
Topics: Oleanolic Acid; Plants; Spectrum Analysis | 1997 |
Saponins from Gliricidia sepium.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Fabaceae; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Optical Rotation; Plant Extracts; Plants, Medicinal; Saponins | 1998 |
Inhibition of mouse ear edema by steroidal and triterpenoid saponins.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Croton Oil; Ear, External; Edema; Hydrocortisone; Indomethacin; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; Plant Extracts; Plants, Medicinal; Random Allocation; Saponins; Triterpenes | 1999 |
In vitro anticomplementary activity of hederagenin saponins isolated from roots of Dipsacus asper.
Topics: Animals; Anti-Inflammatory Agents; Complement Hemolytic Activity Assay; Complement Inactivator Proteins; Hemolysis; Humans; In Vitro Techniques; Oleanolic Acid; Plant Extracts; Saponins; Sheep; Steroids | 1999 |
Essential moiety for antimutagenic and cytotoxic activity of hederagenin monodesmosides and bisdesmosides isolated from the stem bark of Kalopanax pictus.
Topics: Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Mutagenicity Tests; Oleanolic Acid; Plant Stems; Plants, Medicinal; Salmonella typhimurium | 2000 |
Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Glycosides; Humans; Male; Mice; Mice, Inbred Strains; Molecular Structure; Oleanolic Acid; Plant Stems; Plants, Medicinal; Saponins; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Antifungal activity of modified hederagenin glycosides from the leaves of Kalopanax pictum var. chinense.
Topics: Antifungal Agents; Fungi; Glycosides; Magnoliopsida; Microbial Sensitivity Tests; Oleanolic Acid; Plant Leaves | 2001 |
[Analysis of surface-active substances in Sapindus mukurossi by high performance liquid chromatography-mass spectrometry].
Topics: Chromatography, High Pressure Liquid; Mass Spectrometry; Oleanolic Acid; Sapindus; Sesquiterpenes | 2001 |
Antitrichomonas in vitro activity of Cussonia holstii Engl.
Topics: Animals; Antitrichomonal Agents; Araliaceae; Dose-Response Relationship, Drug; Humans; Inhibitory Concentration 50; Oleanolic Acid; Phytotherapy; Plant Bark; Plant Extracts; Trichomonas vaginalis | 2003 |
Isolation of a saponin, hederin, and its sapogenin, hederagenin, from bur clover (Medicago hispida).
Topics: Humans; Intestines; Medicago; Oleanolic Acid; Sapogenins; Saponins; Trifolium | 1957 |
Synthesis and hemolytic activity of some hederagenin diglycosides.
Topics: Acetamides; Carboxylic Acids; Chloroacetates; Disaccharides; Esters; Glycosides; Glycosylation; Hemolysis; Oleanolic Acid; Saponins; Structure-Activity Relationship; Trichloroacetic Acid | 2004 |
Structure elucidation by NMR spectroscopy of a new acetylated saponin from Centratherum anthelminticum.
Topics: Asteraceae; Carbohydrate Sequence; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Oleanolic Acid; Saponins; Seeds | 2004 |
Antinociceptive and anti-inflammatory effects of the saponin and sapogenins obtained from the stem of Akebia quinata.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Butanols; Dose-Response Relationship, Drug; Hydrolysis; Magnoliopsida; Male; Methanol; Mice; Mice, Inbred ICR; Oleanolic Acid; Pain Measurement; Plant Extracts; Plant Stems; Rats; Rats, Sprague-Dawley; Sapogenins; Saponins | 2005 |
[Chemical constituents from rhizome of Pulsatilla dahurica].
Topics: Oleanolic Acid; Plants, Medicinal; Pulsatilla; Rhizome; Saponins; Sitosterols | 2005 |
Cytotoxic saponins from the root of Dipsacus asper Wall.
Topics: Animals; Antineoplastic Agents, Phytogenic; HL-60 Cells; Humans; Leukemia L1210; Mice; Oleanolic Acid; Plant Roots; Plants, Medicinal; Saponins; Structure-Activity Relationship | 2005 |
[Study on sterols and triterpenes from the stems of Akebia quinata].
Topics: Glucosides; Magnoliopsida; Molecular Structure; Oleanolic Acid; Plant Stems; Plants, Medicinal; Sitosterols; Sterols; Stigmasterol; Triterpenes | 2005 |
Structure-activity relationships of some hederagenin diglycosides: haemolysis, cytotoxicity and apoptosis induction.
Topics: Apoptosis; Arabinose; Cell Line, Tumor; Cell Nucleus; Glucose; Glycosylation; Hemolysis; Humans; Molecular Structure; Oleanolic Acid; Saponins; Structure-Activity Relationship | 2006 |
Triterpenoid saponins from the stem bark of Caryocar villosum.
Topics: Adipose Tissue; Cell Survival; Cells, Cultured; Humans; Keratinocytes; Lipolysis; Magnoliopsida; Molecular Structure; Oleanolic Acid; Plant Extracts; Plant Stems; Sapogenins; Saponins; Structure-Activity Relationship; Tissue Culture Techniques; Triterpenes | 2006 |
[Comparative study on quality of Flos Lonicerae between geo-authentic and non-authentic producing areas].
Topics: China; Chlorogenic Acid; Chromium; Cluster Analysis; Ecosystem; Flavonoids; Flowers; Lead; Lonicera; Oleanolic Acid; Plants, Medicinal; Quality Control; Trace Elements | 2007 |
Enhanced triterpene saponin biosynthesis and root nodulation in transgenic barrel medic (Medicago truncatula Gaertn.) expressing a novel beta-amyrin synthase (AsOXA1) gene.
Topics: Aster Plant; Gene Expression; Intramolecular Transferases; Medicago truncatula; Oleanolic Acid; Plant Leaves; Plant Proteins; Plant Roots; Plants, Genetically Modified; RNA, Plant; Saponins; Triterpenes | 2009 |
Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors.
Topics: Cell Line; Cell Line, Tumor; Endocytosis; Hedera; Humans; Oleanolic Acid; Protein Binding; Receptors, Adrenergic, beta-2; Saponins; Thermodynamics | 2009 |
Akebia saponin D, a saponin component from Dipsacus asper Wall, protects PC 12 cells against amyloid-beta induced cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cell Survival; Cytoprotection; Dipsacaceae; Drugs, Chinese Herbal; L-Lactate Dehydrogenase; Oleanolic Acid; PC12 Cells; Rats; Saponins | 2009 |
Identification of defense compounds in Barbarea vulgaris against the herbivore Phyllotreta nemorum by an ecometabolomic approach.
Topics: Animals; Barbarea; Chromatography, Liquid; Cluster Analysis; Coleoptera; Crosses, Genetic; Ecosystem; Feeding Behavior; Larva; Mass Spectrometry; Metabolome; Metabolomics; Oleanolic Acid; Plant Leaves; Principal Component Analysis; Saponins; Survival Analysis | 2009 |
Inhibitory effects of diterpene acids from root of Aralia cordata on IgE-mediated asthma in guinea pigs.
Topics: Airway Resistance; Animals; Aralia; Asthma; Bronchoalveolar Lavage Fluid; Diterpenes; Dose-Response Relationship, Drug; Eosinophils; Guinea Pigs; Histamine; Immunoglobulin E; Leukocytes; Male; Neutrophils; Oleanolic Acid; Phospholipases A2; Plant Extracts | 2010 |
[Chemical constituents of roots of Boehmeria nivea].
Topics: Boehmeria; Drugs, Chinese Herbal; Oleanolic Acid; Plant Roots; Triterpenes | 2009 |
Resistance in the plant, Barbarea vulgaris, and counter-adaptations in flea beetles mediated by saponins.
Topics: Alleles; Animals; Barbarea; Coleoptera; Female; Genotype; Male; Oleanolic Acid; Sapogenins; Saponins | 2010 |
Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula.
Topics: Cloning, Molecular; Cluster Analysis; Cytochrome P-450 Enzyme System; DNA, Plant; Escherichia coli; Gene Expression Regulation, Plant; Glycosylation; Glycosyltransferases; Hydroxylation; Medicago truncatula; Oleanolic Acid; Oligonucleotide Array Sequence Analysis; Plant Proteins; Retroelements; Saponins; Substrate Specificity; Triterpenes | 2010 |
Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clematis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drugs, Chinese Herbal; Molecular Structure; Oleanolic Acid; Plant Roots; Rhizome; Saponins; Triterpenes | 2010 |
The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation.
Topics: Calcium; Cyclic AMP; Free Radical Scavengers; Gene Expression Regulation; Humans; Mitogen-Activated Protein Kinase Kinases; Molecular Structure; NADPH Oxidases; Neutrophil Activation; Oleanolic Acid; Pancreatic Elastase; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Receptors, Formyl Peptide; Sapindus; Saponins | 2010 |
Quantitative determination of hederagenin in rat plasma and cerebrospinal fluid by ultra fast liquid chromatography-tandem mass spectrometry method.
Topics: Acanthaceae; Animals; Chemical Precipitation; Chromatography, High Pressure Liquid; Drug Stability; Drugs, Chinese Herbal; Linear Models; Male; Methanol; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2011 |
Simultaneous determination of asperosaponin VI and its active metabolite hederagenin in rat plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Drug Stability; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2011 |
The extracts of Fructus Akebiae, a preparation containing 90% of the active ingredient hederagenin: serotonin, norepinephrine and dopamine reuptake inhibitor.
Topics: Animals; Biogenic Monoamines; Brain; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Frontal Lobe; HEK293 Cells; Humans; Male; Nerve Tissue Proteins; Neurons; Neurotransmitter Uptake Inhibitors; Norepinephrine Plasma Membrane Transport Proteins; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Serotonin Plasma Membrane Transport Proteins; Synaptosomes; Up-Regulation | 2012 |
Triterpenes from Callicarpa integerrima Champ.
Topics: Betulinic Acid; Callicarpa; Molecular Conformation; Molecular Structure; Oleanolic Acid; Pentacyclic Triterpenes; Plant Leaves; Plant Stems; Plants, Medicinal; Saponins; Triterpenes; Ursolic Acid | 2012 |
Antimicrobially active hederagenin glycosides from Cephalaria elmaliensis.
Topics: Dipsacaceae; Glycosides; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oleanolic Acid; Spectrometry, Mass, Electrospray Ionization | 2012 |
Triterpene acids from Euscaphis japonica and assessment of their cytotoxic and anti-NO activities.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; Lignans; Macrophages; Magnoliopsida; Mice; Molecular Structure; Nitric Oxide; Oleanolic Acid; Plant Extracts; Polysaccharides; Triterpenes | 2012 |
UDP-glycosyltransferases from the UGT73C subfamily in Barbarea vulgaris catalyze sapogenin 3-O-glucosylation in saponin-mediated insect resistance.
Topics: Animals; Barbarea; Biocatalysis; Gene Expression; Gene Expression Regulation, Plant; Gene Library; Glucosyltransferases; Glycosylation; Herbivory; Insecta; Kinetics; Oleanolic Acid; Organ Specificity; Phylogeny; Plant Leaves; Sapogenins; Saponins; Substrate Specificity; Uridine Diphosphate | 2012 |
Chemical constituents of Arisaema franchetianum tubers.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Arisaema; Drug Screening Assays, Antitumor; Female; Glucosides; Glycosides; Humans; Inhibitory Concentration 50; K562 Cells; Lignans; MCF-7 Cells; Molecular Structure; Oleanolic Acid; Plant Tubers; Porcine respiratory and reproductive syndrome virus; Pyrrolidines; Swine | 2013 |
Combinatorial biosynthesis of legume natural and rare triterpenoids in engineered yeast.
Topics: Biosynthetic Pathways; Gene Expression Regulation, Plant; Genes, Plant; Medicago truncatula; Metabolic Engineering; Oleanolic Acid; Phylogeny; Saccharomyces cerevisiae; Saponins; Triterpenes | 2013 |
Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α- and δ-Hederin.
Topics: Cell Line, Tumor; Cell Membrane; Cell Membrane Permeability; Cholesterol; Humans; Lipid Bilayers; Magnetic Resonance Spectroscopy; Membrane Potentials; Microscopy, Fluorescence; Models, Chemical; Monocytes; Oleanolic Acid; Saponins; Sterols; Temperature; Time Factors | 2013 |
[Quality survey of different species of clematidis radix et rhizoma].
Topics: Clematis; Drugs, Chinese Herbal; Oleanolic Acid; Rhizome | 2013 |
Pharmacokinetics study of asperosaponin VI and its metabolites cauloside A, HN saponin F and hederagenin.
Topics: Animals; Chromatography, High Pressure Liquid; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Saponins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Domain formation and permeabilization induced by the saponin α-hederin and its aglycone hederagenin in a cholesterol-containing bilayer.
Topics: Cholesterol; Lipid Bilayers; Membrane Microdomains; Oleanolic Acid; Saponins | 2014 |
Determination of asperosaponin VI and its active metabolite hederagenin in rat tissues by LC-MS/MS: application to a tissue distribution study.
Topics: Animals; Chromatography, High Pressure Liquid; Dipsacaceae; Drugs, Chinese Herbal; Female; Liver; Lung; Male; Oleanolic Acid; Ovary; Rats; Rats, Sprague-Dawley; Saponins; Tandem Mass Spectrometry; Tissue Distribution | 2014 |
Simultaneous quantification of Akebia saponin D and its five metabolites in human intestinal bacteria using ultra-performance liquid chromatography triple quadrupole mass spectrometry.
Topics: Bacteria; Chromatography, High Pressure Liquid; Feces; Humans; Intestines; Mass Spectrometry; Oleanolic Acid; Reproducibility of Results; Saponins; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2014 |
Synthesis of cyclocaric acid A and comparison to material from Cyclocarya paliurus.
Topics: Drugs, Chinese Herbal; Juglandaceae; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid | 2014 |
Hederagenin from the leaves of ivy (Hedera helix L.) induces apoptosis in human LoVo colon cells through the mitochondrial pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Hedera; Humans; Mitochondria; Oleanolic Acid; Plant Extracts; Plant Leaves | 2014 |
Involvement of norepinephrine and serotonin system in antidepressant-like effects of hederagenin in the rat model of unpredictable chronic mild stress-induced depression.
Topics: Animals; Antidepressive Agents; Chronic Disease; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Hippocampus; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Serotonin; Stress, Psychological; Treatment Outcome | 2015 |
[Accumulation dynamic of triterpenoid saponins in Akebia trifoliata stem].
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Magnoliopsida; Oleanolic Acid; Plant Stems; Saponins | 2014 |
Antifungal properties of a new terpernoid saponin and other compounds from the stem bark of Polyscias fulva Hiern (Araliaceae).
Topics: Antifungal Agents; Araliaceae; Arthrodermataceae; Oleanolic Acid; Plant Bark; Plant Extracts; Plant Stems; Saponins; Spores, Fungal; Terpenes; Yeasts | 2015 |
Bioassay Guided Fractionation Identified Hederagenin as a Major Cytotoxic Agent from Cyclocarya paliurus Leaves.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chemical Fractionation; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Juglandaceae; Molecular Structure; Oleanolic Acid; Plant Leaves; Structure-Activity Relationship | 2016 |
Hederagenin as a triterpene template for the development of new antitumor compounds.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship | 2015 |
Hederagenin, a major component of Clematis mandshurica Ruprecht root, attenuates inflammatory responses in RAW 264.7 cells and in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Clematis; Cytokines; Dose-Response Relationship, Drug; Edema; Foot; Inflammation; Lipopolysaccharides; Mice; Oleanolic Acid; Plant Roots; RAW 264.7 Cells; Skin | 2015 |
[Chemical Components from Leaves of Fatsia japonica and Their Antitumor Activities in vitro].
Topics: Antineoplastic Agents, Phytogenic; Araliaceae; Betulinic Acid; Cell Line, Tumor; Chromatography, High Pressure Liquid; Flavones; Furans; Glucosides; Humans; Kaempferols; Lactones; Lignans; Oleanolic Acid; Pentacyclic Triterpenes; Phytochemicals; Plant Leaves; Sitosterols; Triterpenes | 2015 |
Oleanolic acid and hederagenin glycosides from Weigela stelzneri.
Topics: Caprifoliaceae; Dose-Response Relationship, Drug; Glycosides; Interleukin-1beta; Lipopolysaccharides; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Plant Roots; Stereoisomerism | 2016 |
[Chemical Constituents from Angelica keiskei].
Topics: Angelica; Flavonoids; Glucosides; Kaempferols; Oleanolic Acid; Phytochemicals; Quercetin | 2015 |
Novel hederagenin-triazolyl derivatives as potential anti-cancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Oleanolic Acid; Triazoles | 2016 |
Development and validation of a quantification method for oleanolic acid and hederagenin in rat plasma: application to the pharmacokinetic study.
Topics: Animals; Chromatography, High Pressure Liquid; Clematis; Drugs, Chinese Herbal; Limit of Detection; Liquid-Liquid Extraction; Male; Oleanolic Acid; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2017 |
Highly potent anti-leishmanial derivatives of hederagenin, a triperpenoid from Sapindus saponaria L.
Topics: Antiprotozoal Agents; Hep G2 Cells; Humans; Intracellular Space; Leishmania infantum; Oleanolic Acid; Saponaria; Structure-Activity Relationship | 2016 |
Microbial transformation of hederagenin by Cunninghamella echinulate, Mucor subtilissimus, and Pseudomonas oleovorans.
Topics: Biotransformation; Cunninghamella; Molecular Structure; Mucor; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Pseudomonas oleovorans; Saponins | 2017 |
Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenylate Kinase; alpha-Synuclein; Animals; Autophagy; Cell Line, Tumor; Disease Models, Animal; Drugs, Chinese Herbal; Female; Hedera; Huntingtin Protein; Male; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; Oleanolic Acid; PC12 Cells; Rats; Saponins; TOR Serine-Threonine Kinases | 2017 |
Screening for Triterpenoid Saponins in Plants Using Hyphenated Analytical Platforms.
Topics: Barbarea; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Oleanolic Acid; Plant Leaves; Saponins; Triterpenes | 2016 |
Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats.
Topics: Alanine Transaminase; Alcohol Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransferases; bcl-2-Associated X Protein; Cholesterol; Cyclooxygenase 2; Dietary Supplements; Ethanol; Inflammation; Interleukin-6; Liver; Liver Diseases; Male; Oleanolic Acid; Phosphorylation; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Triglycerides; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2017 |
Artefact formation during acid hydrolysis of saponins from Medicago spp.
Topics: Artifacts; Gas Chromatography-Mass Spectrometry; Glycosides; Hydrolysis; Magnetic Resonance Spectroscopy; Medicago; Molecular Structure; Oleanolic Acid; Saponins; Triterpenes | 2017 |
Interactions between erythromycin, flunixin meglumine, levamisole and plant secondary metabolites towards bovine gastrointestinal motility-in vitro study.
Topics: Abomasum; Animals; Apigenin; Cattle; Clonixin; Drug Interactions; Duodenum; Erythromycin; Female; Gastrointestinal Motility; In Vitro Techniques; Levamisole; Muscle Contraction; Muscle, Smooth; Oleanolic Acid; Quercetin; Secondary Metabolism; Triterpenes | 2018 |
Leishmanicidal and cytotoxic activity of hederagenin-bistriazolyl derivatives.
Topics: Animals; Antiprotozoal Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cells, Cultured; Dogs; Hep G2 Cells; Humans; Leishmaniasis; Oleanolic Acid; Proton Magnetic Resonance Spectroscopy; Triazoles | 2017 |
Design, synthesis and biological evaluation of novel α-hederagenin derivatives with anticancer activity.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured | 2017 |
Transcriptomic Analysis of Kalopanax septemlobus and Characterization of KsBAS, CYP716A94 and CYP72A397 Genes Involved in Hederagenin Saponin Biosynthesis.
Topics: Biocatalysis; Biosynthetic Pathways; Cytochrome P-450 Enzyme System; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Kalopanax; Mevalonic Acid; Oleanolic Acid; Phylogeny; Plant Proteins; Saccharomyces cerevisiae; Saponins; Transcriptome | 2018 |
H6, a novel hederagenin derivative, reverses multidrug resistance in vitro and in vivo.
Topics: Animals; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Male; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Oleanolic Acid; Xenograft Model Antitumor Assays | 2018 |
Immunomodulatory, hemolytic and cytotoxic activity potentials of triterpenoid saponins from eight Cephalaria species.
Topics: Antineoplastic Agents, Phytogenic; Dipsacaceae; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; HEK293 Cells; HeLa Cells; Hemolysis; Hemolytic Agents; Humans; Immunologic Factors; Oleanolic Acid; Saponins; Triterpenes; Turkey | 2018 |
Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; Head and Neck Neoplasms; Hedera; Humans; Membrane Potential, Mitochondrial; Mice; NF-E2-Related Factor 2; Oleanolic Acid; Oxidation-Reduction; Signal Transduction; Xenograft Model Antitumor Assays | 2017 |
A tandem array of UDP-glycosyltransferases from the UGT73C subfamily glycosylate sapogenins, forming a spectrum of mono- and bisdesmosidic saponins.
Topics: Barbarea; Brassinosteroids; Escherichia coli; Genes, Plant; Glycosides; Glycosylation; Glycosyltransferases; Models, Molecular; Nicotiana; Oleanolic Acid; Sapogenins; Saponins; Steroids, Heterocyclic; Tandem Repeat Sequences; Transcriptome | 2018 |
[Biosynthesis analysis of hederagenin pathway and its construction in yeast cells].
Topics: Biosynthetic Pathways; Cell Count; Oleanolic Acid; Saccharomyces cerevisiae | 2018 |
Design, Synthesis, and Cytotoxic Analysis of Novel Hederagenin⁻Pyrazine Derivatives Based on Partial Least Squares Discriminant Analysis.
Topics: Apoptosis; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Shape; Cluster Analysis; Discriminant Analysis; Drug Design; Humans; Inhibitory Concentration 50; Least-Squares Analysis; Oleanolic Acid; Principal Component Analysis; Pyrazines; Staining and Labeling; Structure-Activity Relationship | 2018 |
Synthesis and biological evaluation of novel H6 analogues as drug resistance reversal agents.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Oleanolic Acid; Structure-Activity Relationship; Tumor Cells, Cultured | 2019 |
Modulations of bovine hepatic microsomal metabolism of benzimidazoles by secondary plant metabolites.
Topics: Albendazole; Animals; Apigenin; Cattle; Chromatography, High Pressure Liquid; Fenbendazole; Microsomes, Liver; Oleanolic Acid; Phytochemicals; Quercetin; Triterpenes | 2019 |
The cytochrome P450 CYP72A552 is key to production of hederagenin-based saponins that mediate plant defense against herbivores.
Topics: Animals; Barbarea; Cytochrome P-450 Enzyme System; Gene Duplication; Genome, Plant; Herbivory; Insecta; Moths; Oleanolic Acid; Oxidation-Reduction; Phylogeny; Quantitative Trait Loci; Saponins | 2019 |
Hederagenin amide derivatives as potential antiproliferative agents.
Topics: Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Microscopy, Fluorescence; Molecular Docking Simulation; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship | 2019 |
[Hederagenin inhibits proliferation and promotes apoptosis of cervical cancer CaSki cells by blocking STAT3 pathway].
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Female; Humans; Oleanolic Acid; STAT3 Transcription Factor; Uterine Cervical Neoplasms | 2019 |
Hederagenin glycosides from the fruits of Blighia unijugata.
Topics: Blighia; Fruit; Glycosides; Models, Molecular; Molecular Conformation; Oleanolic Acid | 2019 |
Anti-inflammatory effects of Hederacoside-C on Staphylococcus aureus induced inflammation via TLRs and their downstream signal pathway in vivo and in vitro.
Topics: Animals; Anti-Inflammatory Agents; Drugs, Chinese Herbal; Female; Hedera; Humans; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; NF-kappa B; Oleanolic Acid; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus; Toll-Like Receptor 2; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha | 2019 |
Hederagenin protects mice against ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and bone resorption.
Topics: Animals; Bone Resorption; Female; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Oleanolic Acid; Osteogenesis; Ovariectomy; Protective Agents; RANK Ligand; Signal Transduction | 2020 |
The protective effect of Hederagenin on pulmonary fibrosis by regulating the Ras/JNK/NFAT4 axis in rats.
Topics: Animals; Bleomycin; Cytokines; Epithelial-Mesenchymal Transition; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; NFATC Transcription Factors; Oleanolic Acid; Phosphorylation; Protective Agents; Pulmonary Fibrosis; ras Proteins; Rats; Rats, Sprague-Dawley | 2020 |
Synthesis, Characterization and Anti-hepatoma Activity of New Hederagenin Derivatives.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship | 2020 |
Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells.
Topics: Animals; Antineoplastic Agents; Autophagy; Cell Line, Tumor; Cell Proliferation; Cisplatin; Humans; Lung Neoplasms; Lysosomes; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Oleanolic Acid; Paclitaxel; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2020 |
Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity.
Topics: Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship | 2021 |
A hederagenin-type triterpene saponin, sumbulianoside a from
Topics: Dipsacaceae; HEK293 Cells; Humans; Influenza A Virus, H3N2 Subtype; Interleukin-4; Oleanolic Acid; Saponins; Seasons; Triterpenes | 2022 |
Evaluation of the anti-Toxoplasma gondii Activity of Hederagenin in vitro and in vivo.
Topics: Animals; Aspartate Aminotransferases; Mice; Oleanolic Acid; Toxoplasma; Toxoplasmosis | 2021 |
Triterpenoid saponins and others glycosides from the stem barks of Pancovia turbinata Radlk.
Topics: Glycosides; Oleanolic Acid; Sapindaceae; Saponins | 2021 |
Inhibitory effect of hederagenin on Streptococcus pneumoniae pneumolysin in vitro.
Topics: Bacterial Proteins; Humans; Oleanolic Acid; Pneumococcal Infections; Streptococcus pneumoniae; Streptolysins | 2022 |
Immunomodulatory and anti-inflammatory efficacy of hederagenin-coated maghemite (γ-Fe
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Dermatitis, Atopic; Ferric Compounds; Mice; Mice, Inbred BALB C; Nanoparticles; Oleanolic Acid; Skin | 2022 |
Utility of the combination of hederagenin glucoside saponins and chromane hydrazone in the topical treatment of canine cutaneous leishmaniasis. An observational study.
Topics: Animals; Antiprotozoal Agents; Dogs; Female; Glucosides; Hydrazones; Leishmaniasis, Cutaneous; Male; Mice; Ointments; Oleanolic Acid; Saponins; Swine | 2022 |
Identification of a novel anticancer mechanism of Paeoniae Radix extracts based on systematic transcriptome analysis.
Topics: A549 Cells; Antineoplastic Agents, Phytogenic; Aurora Kinase B; Gene Expression Profiling; Humans; Lung Neoplasms; Oleanolic Acid; Paeonia; Plant Extracts; Plant Roots | 2022 |
Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Mice, Nude; Nitrogen; Oleanolic Acid | 2022 |
The protective effect of hederagenin on renal fibrosis by targeting muscarinic acetylcholine receptor.
Topics: Cell Line; Fibrosis; Humans; Kidney; Kidney Diseases; Oleanolic Acid; Pilocarpine; Receptors, Muscarinic; Transforming Growth Factor beta | 2022 |
Hederagenin Exerts Potential Antilipemic Effect via p38MAPK Pathway in Oleic Acid-induced HepG2 cells and in Hyperlipidemic Rats.
Topics: Animals; Cholesterol, LDL; Hep G2 Cells; Humans; Hypolipidemic Agents; Oleanolic Acid; Oleic Acid; p38 Mitogen-Activated Protein Kinases; Rats; Simvastatin; Superoxide Dismutase | 2022 |
Hederagenin ameliorates cisplatin-induced acute kidney injury via inhibiting long non-coding RNA A330074k22Rik/Axin2/β-catenin signalling pathway.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; beta Catenin; Cisplatin; Disease Models, Animal; Inflammation; Kidney; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Oleanolic Acid; RNA, Long Noncoding; RNA, Messenger; RNA, Small Interfering; Saponins | 2022 |
Comparative genomics of the medicinal plants Lonicera macranthoides and L. japonica provides insight into genus genome evolution and hederagenin-based saponin biosynthesis.
Topics: COVID-19; Evolution, Molecular; Genomics; Humans; Lonicera; Oleanolic Acid; Plants, Medicinal; Saponins | 2023 |